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https://www.readbyqxmd.com/read/28938308/sensor-based-physiologic-control-strategy-for-biventricular-support-with-rotary-blood-pumps
#1
Yu Wang, Steven C Koenig, Zhongjun Wu, Mark S Slaughter, Guruprasad A Giridharan
Rotary biventricular assist devices (BiVAD) are becoming a clinically accepted treatment option for end-stage biventricular failure. To improve BiVAD efficacy and safety, we propose a control algorithm to achieve the clinical objectives of maintaining left-right-sided balance, restoring physiologic flows, and preventing ventricular suction. The control algorithm consists of two proportional-integral (PI) controllers for left and right ventricular assist devices (LVAD and RVAD) to maintain differential pump pressure across LVAD (ΔPL) and RVAD (ΔPR) to provide left-right balance and physiologic flow...
September 21, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28938307/design-and-development-of-a-miniaturized-percutaneously-deployable-wireless-left-ventricular-assist-device-early-prototypes-and-feasibility-testing
#2
Brian Letzen, Jiheum Park, Zeynep Tuzun, Pramod Bonde
The current left ventricular assist devices (LVADs) are limited by a highly invasive implantation procedure in a severely unstable group of advanced heart failure patients. Additionally, the current transcutaneous power drive line acts as a nidus for infection resulting in significant morbidity and mortality. In an effort to decrease this invasiveness and eliminate drive line complications, we have conceived a wireless miniaturized percutaneous LVAD, capable of being delivered endovascularly with a tether-free operation...
September 21, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28936580/use-of-cardiopulmonary-pump-support-during-coronary-artery-bypass-grafting-in-the-high-risk-a-meta-analysis
#3
A Yousif, D Addison, N Lakkis, T Rosengart, S S Virani, Y Birnbaum, M Alam
BACKGROUND: Data from randomized trials evaluating the efficacy of on- versus off-pump coronary artery bypass grafting remain inconclusive, particularly in high-risk populations. AIMS: The aim of this study is to compare the outcomes associated with on- versus off-pump coronary artery bypass grafting among high-risk patients. METHODS: We performed a meta-analysis of randomized control trials comparing on- versus off-pump coronary artery bypass grafting, focusing on high-risk populations...
September 21, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28935461/short-and-long-term-outcome-in-very-old-patients-with-st-elevation-myocardial-infarction-after-primary-percutaneous-coronary-intervention
#4
Roberta Sappa, Maria Teresa Grillo, Martino Cinquetti, Giulio Prati, Leonardo Spedicato, Gaetano Nucifora, Andrea Perkan, Davide Zanuttini, Gianfranco Sinagra, Alessandro Proclemer
BACKGROUND: Although octogenarians constitute a fast-growing portion of cardiovascular patients, few data are available on the outcome of patients aged ≥85 years with ST-Elevation Myocardial Infarction (STEMI). METHODS AND RESULTS: We analyzed 126 consecutive patients aged ≥85 years (age 88±2 years) with STEMI, undergoing primary percutaneous coronary intervention (pPCI) within 12 hours from symptoms onset. Long-term follow-up (median 898 days) was obtained for the 102 patients surviving the index-hospitalization...
September 13, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28935351/impact-of-left-ventricular-assist-device-related-complications-on-posttransplant-graft-survival
#5
Dhaval Chauhan, Alexis K Okoh, Setri Fugar, Rivandra Karanam, David Baran, Mark Zucker, Magarita Camacho, Mark J Russo
BACKGROUND: This study describes the impact of continuous-flow left-ventricular-assist device (CF-LVAD)-related complications on postoperative outcomes. METHODS: The United Network for Organ Sharing (UNOS) heart transplant follow-up data from 2005 to 2015 were obtained. CF-LVAD patients who were bridged to transplant were studied. Device-related complications (DRCs) at patient's last follow-up before transplantation were reported in 5 categories: device thrombosis (B1), infection (B2), device malfunction (B3), life-threatening arrhythmias (B4), and others (B5)...
September 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28935323/first-implantation-of-a-novel-left-ventricular-assist-device-the-reliantheart-avad
#6
Jan D Schmitto, Jasmin S Hanke, Guenes Dogan, Rene Tessmann, Valluvan Jeevanandem, William E Cohn, O H Frazier, Axel Haverich
aVAD (ReliantHeart Inc, Houston, TX) is a new, compact, axial flow left ventricular assist device with novel features including real flow measurement, remote device monitoring, and a miniaturized pump housing. The aVAD received Conformité Européenne marking in August 2016. The use of this device was performed in a 61-year-old woman with severe heart failure. Following uneventful surgery, the patient recovered and was successfully discharged from the hospital.
October 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28934837/bromocriptine-for-the-treatment-of-peripartum-cardiomyopathy-a-multicentre-randomized-study
#7
Denise Hilfiker-Kleiner, Arash Haghikia, Dominik Berliner, Jens Vogel-Claussen, Johannes Schwab, Annegret Franke, Marziel Schwarzkopf, Philipp Ehlermann, Roman Pfister, Guido Michels, Ralf Westenfeld, Verena Stangl, Ingrid Kindermann, Uwe Kühl, Christiane E Angermann, Axel Schlitt, Dieter Fischer, Edith Podewski, Michael Böhm, Karen Sliwa, Johann Bauersachs
Aims: An anti-angiogenic cleaved prolactin fragment is considered causal for peripartum cardiomyopathy (PPCM). Experimental and first clinical observations suggested beneficial effects of the prolactin release inhibitor bromocriptine in PPCM. Methods and results: In this multicentre trial, 63 PPCM patients with left ventricular ejection fraction (LVEF) ≤35% were randomly assigned to short-term (1W: bromocriptine, 2.5 mg, 7 days) or long-term bromocriptine treatment (8W: 5 mg for 2 weeks followed by 2...
September 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28934669/transforming-growth-factor-beta-tgf-%C3%AE-mediates-cardiac-fibrosis-and-induces-diabetic-cardiomyopathy
#8
REVIEW
Yiyang Yue, Ke Meng, Yuejie Pu, Xiaoming Zhang
Cardiovascular diseases account for the major cause of morbidity and mortality among individuals with diabetes. The diabetic cardiomyopathy (DCM) is a type of diabetic cardiovascular disease, which further directs to the heart failure. The researchers found that diabetes induced cardiac fibrosis plays a vital role in several of the pathological changes that associated with DCM, causing left ventricular hypertrophy (LVH), diastolic dysfunction and systolic dysfunction. However, the mechanisms involved in the pathogenesis of DCM are still elusive...
September 1, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28933308/polymorphism-gln27glu-of-%C3%AE-2-adrenergic-receptors-in-patients-with-ischaemic-cardiomyopathy
#9
Sofia Metaxa, Constantinos Missouris, Depy Mavrogianni, Antigoni Miliou, Evangelos Oikonomou, Antonios Vlismas, Eirini Toli, Lambrini Kormali, Peter Drakakis, Dimitris Tousoulis
BACKGROUND: Polymorphisms of the adrenergic receptors (ARs) might affect the development and progression of heart failure (HF) and the response to treatment with β-blockade therapy. OBJECTIVE: To examine the role of the Gln27Glu polymorphism of β2-AR in HF development and to assess the hypothesis that Gln27Glu is associated with coronary artery disease in patients with ischaemic HF. METHODS: In this case control study we enrolled 155 consecutive patients with symptomatic HF of ischaemic aetiology with impaired left ventricular ejection fraction (LVEF) ≤35%...
September 19, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28933176/-myocarditis-and-inflammatory-cardiomyopathy
#10
Dalibor Mlejnek, Jan Krejčí
Myocarditis is an inflammation of the heart muscle. The most common cause of myocarditis is viral infection in industrialized countries. Myocarditis with left ventricular dysfunction is called inflammatory cardiomyopathy and is the major cause of dilated cardiomyopathy. The clinical picture is very diverse, most often the patient present with signs of heart failure, arrhythmic symptoms and chest pains. Despite significant advances in non-invasive diagnostics, particularly magnetic resonance imaging, endomyocardial biopsy remains the gold standard of myocarditis diagnosis...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28932915/outcomes-in-patients-with-advanced-heart-failure-and-small-body-size-undergoing-continuous-flow-left-ventricular-assist-device-implantation
#11
Nastasya Volkovicher, Chitaru Kurihara, Andre Critsinelis, Masashi Kawabori, Tadahisa Sugiura, Marcos Manon, Andrew B Civitello, Jeffrey A Morgan
Left ventricular assist devices (LVADs) have become a preferred treatment option for patients with end-stage heart failure when used as a bridge to transplant or as a destination therapy. However, the association between small body size and postoperative outcomes for continuous-flow (CF) LVAD recipients is still being studied. We sought to determine whether body surface area (BSA) is associated with patient outcomes after CF-LVAD implantation. The study cohort of our single-center, retrospective review consisted of all patients (n = 526) who underwent CF-LVAD implantation (n = 403 HeartMate II, n = 123 HeartWare) between November 2003 and March 2016 regardless of indication...
September 20, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28931700/peritoneal-dialysis-for-the-treatment-of-cardiorenal-syndrome-type-1-a-prospective-brazilian-study
#12
Daniela Ponce, Cassiana Góes, Mariele Oliveira, Andre Balbi
This study aimed to explore the role of high-volume peritoneal dialysis (HVPD) in cardiorenal syndrome (CRS) type 1 patients in relation to metabolic and fluid control and outcome. Sixty-four patients were treated by HVPD (prescribed Kt/V = 0.50/session), flexible catheter and cycler. Mean age was 68.8 ± 15.4 years, 54.7% needed intravenous inotropic agents and/or intravenous vasodilators, 31.2% were on mechanical ventilation, acute coronary syndrome (ACS) was the main cause of acute disease heart failure (ADHF) 48...
September 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28931551/endoplasmic-reticulum-membrane-protein-complex-subunit-10-emc10-is-a-bone-marrow-derived-angiogenic-growth-factor-promoting-tissue-repair-after-myocardial-infarction
#13
Marc R Reboll, Mortimer Korf-Klingebiel, Stefanie Klede, Felix Polten, Eva Brinkmann, Ines Reimann, Hans-Joachim Schönfeld, Maria Bobadilla, Jan Faix, George Kensah, Ina Gruh, Michael Klintschar, Matthias Gaestel, Hans W Niessen, Andreas Pich, Johann Bauersachs, Joseph A Gogos, Yong Wang, Kai C Wollert
Background -Clinical trials of bone marrow cell (BMC)-based therapies after acute myocardial infarction (MI) have produced mostly neutral results. Treatment with specific BMC-derived secreted proteins may provide an alternative biologic approach to improving tissue repair and heart function after MI. We recently performed a bioinformatic secretome analysis in BMCs from patients with acute MI and discovered a poorly characterized secreted protein, endoplasmic reticulum membrane protein complex subunit 10 (EMC10), showing activity in an angiogenic screen...
September 20, 2017: Circulation
https://www.readbyqxmd.com/read/28931529/electrocardiographic-strain-pattern-is-associated-with-left-ventricular-concentric-remodeling-scar-and-mortality-over-10%C3%A2-years-the-multi-ethnic-study-of-atherosclerosis
#14
Yuko Y Inoue, Elsayed Z Soliman, Kihei Yoneyama, Bharath Ambale-Venkatesh, Colin O Wu, Rodney Sparapani, David A Bluemke, João A C Lima, Hiroshi Ashikaga
BACKGROUND: Both ECG strain pattern and QRS measured left ventricular (LV) hypertrophy criteria are associated with LV hypertrophy and have been used for risk stratification. However, the independent predictive value of ECG strain in apparently healthy individuals in predicting mortality and adverse cardiovascular events is unclear. METHODS AND RESULTS: MESA (Multi-Ethnic Study of Atherosclerosis) is a multicenter, prospective cohort of 6441 participants (mean age, 62 years; 54% women)...
September 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28931437/acute-reverse-annular-remodeling-during-mitraclip-%C3%A2-therapy-predicts-improved-clinical-outcome-in-heart-failure-patients-a-3d-echocardiography-study
#15
Theresa Herbrand, Silke Eschenhagen, Tobias Zeus, Eva Kehmeier, Katharina Hellhammer, Verena Veulemans, Malte Kelm, Jan Balzer
BACKGROUND: Transcatheter mitral valve repair (TMVR) has been shown to have acute effects on mitral valve geometry in patients with functional mitral regurgitation (FMR). This study investigates the impact of MitraClip(®) therapy-induced annular remodeling on clinical outcome and mitral regurgitation in heart failure patients. METHODS: TMVR was performed successfully in 45 patients with FMR. In this study, mitral valve datasets were obtained before and directly after MitraClip(®) implantation using three-dimensional (3D) transesophageal echocardiography, and were analyzed offline retrospectively using dedicated 3D reconstruction software...
September 20, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28929616/noninvasive-assessment-of-left-ventricular-end-diastolic-pressure-by-deceleration-time-of-early-diastolic-mitral-annular-velocity-in-patients-with-heart-failure
#16
Kazushi Takemoto, Kumiko Hirata, Takeshi Hozumi, Takashi Tanimoto, Makoto Orii, Yasutsugu Shiono, Yoshiki Matsuo, Yasushi Ino, Hironori Kitabata, Takashi Kubo, Atsushi Tanaka, Takashi Akasaka
OBJECTIVE: To examine the diagnostic ability of the deceleration time of early mitral annular velocity (e'DT) as determined by tissue Doppler velocity image, a method for assessing LV filling pressure. BACKGROUNDS: Estimation of LV filling pressure by Doppler echocardiography requires a combination of various parameters. Therefore, there remains a need for a simple index in LV filling pressure estimation. The e' is known to be reduced and delayed with increased LV filling pressure during development of heart failure...
September 2017: Echocardiography
https://www.readbyqxmd.com/read/28929529/correlation-between-myocardial-deformation-on-three-dimensional-speckle-tracking-echocardiography-and-cardiopulmonary-exercise-testing
#17
Mei Li, Yaran Lu, Cui Fang, Xiaorong Zhang
PURPOSE: Heart failure (HF) is a multifactorial entity that combines derangements in both systolic and diastolic function. The relationship between systolic and diastolic function and exercise capacity is not fully understood. We sought to determine the mechanisms linking cardiac function and exercise tolerance in patients with HF. METHODS: One hundred fifty-six subjects with different cardiac function levels were included in the study. Subjects' 2D echocardiographic, 3D speckle tracking echocardiographic, and cardiopulmonary exercise testing (CPET) data were collected...
September 19, 2017: Echocardiography
https://www.readbyqxmd.com/read/28929382/serial-assessment-of-left-ventricular-morphology-and-function-in-a-rodent-model-of-ischemic-cardiomyopathy
#18
Vesselina Ferferieva, Nicholas D'Elia, Brecht Heyde, Petr Otahal, Frank Rademakers, Jan D'hooge
Left ventricular remodelling (LVr) occurs post myocardial infarction (MI), predisposing people to heart failure (HF). LV mechanics and morphology are important in this process. We hence sort to characterize LV mechanics and geometry in a post-MI rodent model. Thirty-two male Sprague-Dawley rats (150-200 g) sustained MI (n = 24) or sham (Sham; n = 8) surgery. In another six sham rats invasive blood pressure measurements were performed. Ultrasound imaging was done at baseline, and 1, 3, 7, 14, 30 and 60 days following surgery, and LV mechanics and morphology assessed...
September 19, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28929118/natriuretic-peptide-system-activation-in-acute-heart-failure-patients-with-diabetes
#19
Filipe M Cunha, Joana Pereira, Pedro Marques, Helena Moreira, Pedro Rodrigues, Maria João Pinto, Patrícia Lourenço, Paulo Bettencourt
BACKGROUND: Elevated B-type natriuretic peptide (BNP) is a hallmark in heart failure (HF). Diabetic patients with chronic HF seem to have higher BNP than nondiabetics. We studied, in acute HF, if BNP levels are different between diabetics and nondiabetics. METHODS: From a prospectively recruited population of acute HF patients, we selected a convenience sample. In pair-matched analysis, each diabetic patient was matched with a nondiabetic of the same age (±1 year), gender, and according to left ventricular systolic dysfunction...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28928990/detection-of-a-left-superior-vena-cava-during-a-pacemaker-implantation-in-cotonou
#20
A Sonou, M Hounkponou, L Codjo, P M Adjagba, C Houehanou, H Dohou, S Assani, Y Tchabi, M Houenassi
Persistent left superior vena cava (LSVC) is a rare congenital anomaly. Its prevalence in the general population is 0.1 to 0.5%. LSVC is 5 times rarer when accompanied by an absence of the right superior vena cava (RSVC). We present the case of a 54-year-old man who carries a persistent LSVC without RSVC. Clinically, this patient presented a regular bradycardia at 40 per minute associated with a heart failure syndrome. The electrocardiogram diagnosed a complete atrioventricular block and transthoracic echocardiography showed dilated left heart cavities and a left ventricular ejection fraction of 50%...
2017: Case Reports in Cardiology
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