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microinvasive carcinoma of uterine cervix

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https://www.readbyqxmd.com/read/27757531/-metastatic-mechanisms-of-uterine-malignancies-and-therapeutic-consequences
#1
S F Lax, K F Tamussino, P F Lang
Malignancies of the uterus metastasize by direct invasion of neighboring structures, lymphatically or hematogenously. Endometrial and cervical cancers lymphatically spread to the pelvic and para-aortic lymph nodes. For endometrial cancer the depth of myometrial invasion, lymphosvascular space involvement (LVSI) and a microcystic, elongated and fragmented (MELF) glandular invasion pattern are predictors for lymph node metastases. Metastases to the pelvic lymph nodes occur in approximately 10 % of endometrial cancer patients and in 30 % of these cases the para-aortic lymph nodes are also involved...
October 18, 2016: Der Pathologe
https://www.readbyqxmd.com/read/27644654/does-microinvasive-adenocarcinoma-of-cervix-have-poorer-treatment-outcomes-than-microinvasive-squamous-cell-carcinoma
#2
Irene Ruengkhachorn, Suchanan Hanamornroongruang, Chairat Leelaphatanadit, Suthi Sangkarat
BACKGROUND: To compare the pathological findings and oncologic outcomes of stage IA cervical carcinoma patients, between adenocarcinoma and squamous cell carcinoma cases. MATERIALS AND METHODS: A total of 151 medical records of stage IA cervical carcinoma patients undergoing primary surgical treatment during 2006-2013 were reviewed. Information from pathological diagnosis and recurrence rates were compared with descriptive statistical analysis. The Kaplan-Meier method and Cox proportional hazards model were used for survival analysis...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/25955908/avaliation-of-residual-disease-in-hysterectomy-specimens-after-conization-in-women-treated-for-squamous-microinvasive-carcinoma-of-the-uterine-cervix-igcs-0064-cervical-cancer
#3
C A Hartman, M S C Gurgel, J C Teixeira, S M Figueiredo, J Y Yoneda, O F Rangel, Braganca J Bastos
No abstract text is available yet for this article.
May 2015: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/25738363/progression-of-naive-intraepithelial-neoplasia-genome-to-aggressive-squamous-cell-carcinoma-genome-of-uterine-cervix
#4
Seung-Hyun Jung, Youn Jin Choi, Min Sung Kim, In-Pyo Baek, Sung Hak Lee, Ah Won Lee, Soo Young Hur, Tae-Min Kim, Sug Hyung Lee, Yeun-Jun Chung
Although cervical intraepithelial neoplasia (CIN) is considered a neoplasia, its genomic alterations remain unknown. For this, we performed whole-exome sequencing and copy number profiling of three CINs, a microinvasive carcinoma (MIC) and four cervical squamous cell carcinomas (CSCC). Both total mutation and driver mutation numbers of the CINs were significantly fewer than those of the MIC/CSCCs (P = 0.036 and P = 0.018, respectively). Importantly, PIK3CA was altered in all MIC/CSCCs by either mutation or amplification, but not in CINs...
February 28, 2015: Oncotarget
https://www.readbyqxmd.com/read/25579181/timp-2-gene-methylation-in-cervical-precursor-and-invasive-lesions
#5
Yara Furtado, Gutemberg Almeida, Filomena Aste Silveira, Kátia S Silva, Paula Maldonado, Isabel Cristina do Val, Silvia Cavalcanti, Miranda-Alves L, Maria da Gloria da Costa Carvalho
OBJECTIVE: To analyze the presence of HPV-DNA and TIMP-2 gene methylation in cervical precursor and invasive lesions, as well as to study the associations among the latter, the presence of HPV-DNA, and the clinical evolution of such lesions. METHODS: Cross-sectional study that includes 49 biopsy or brush smear samples from women with a normal cervix, LSIL, HSIL, microinvasive carcinoma and invasive carcinoma. The presence of HPV-DNA and specific methylation was analyzed using PCR...
February 2015: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/25507438/multifocal-microinvasive-squamous-cell-carcinoma-with-extensive-spread-of-squamous-cell-carcinoma-in-situ-cis-into-the-uterine-corpus-vagina-and-left-salpinx-diagnosed-five-years-after-conization-of-cervical-cis
#6
S W Yang, W Y Kim, S H Cho, S H Yoon, J Y Lim, S J Leet
BACKGROUND: Multifocal microinvasive squamous cell carcinoma (SCC) with extensive spread of squamous cell carcinoma in situ (CIS) into the uterine corpus, salpinx, and vagina is extremely unusual. CASE: The authors present a case of 69-year-old woman with hydrometra who was found to have multifocal microinvasive SCC in the endometrium. The CIS had spread superficially throughout the entire endometrium up to the fundus, completely replacing the epithelium. The uterine cervix, vaginal surface and left salpingeal mucosa were involved...
2014: European Journal of Gynaecological Oncology
https://www.readbyqxmd.com/read/25423715/multifocal-microinvasive-squamous-cell-carcinoma-with-extensive-spread-of-squamous-cell-carcinoma-in-situ-cis-into-the-uterine-corpus-vagina-and-left-salpinx-diagnosed-five-years-after-conization-of-cervical-cis
#7
S W Yang, W Y Kim, S H Cho, S H Yoon, J Y Lim, S J Leet
BACKGROUND: Multifocal microinvasive squamous cell carcinoma (SCC) with extensive spread of squamous cell carcinoma in situ (CIS) into the uterine corpus, salpinx, and vagina is extremely unusual. CASE: The authors present a case of 69-year-old woman with hydrometra who was found to have multifocal microinvasive SCC in the endometrium. The CIS had spread superficially throughout the entire endometrium up to the fundus, completely replacing the epithelium. The uterine cervix, vaginal surface and left salpingeal mucosa were involved...
2014: European Journal of Gynaecological Oncology
https://www.readbyqxmd.com/read/25348708/clinical-approaches-to-treating-papillary-squamous-cell-carcinoma-of-the-uterine-cervix
#8
Michikazu Nagura, Masafumi Koshiyama, Noriomi Matsumura, Aki Kido, Tsukasa Baba, Kaoru Abiko, Junzo Hamanishi, Ken Yamaguchi, Yoshiki Mikami, Ikuo Konishi
BACKGROUND: Papillary squamous cell carcinoma (PSCC) of the uterine cervix is difficult to diagnose due to its rarity and limited data regarding its clinical behavior. We attempted to assess the degree of stromal invasion using magnetic resonance imaging (MRI) and evaluate possible treatments for this lesion in view of its clinical behavior. METHODS: We analyzed 28 cases of PSCC diagnosed on the colposcopic selective biopsies. We studied the rate of accuracy of diagnoses of the colposcopic selective biopsies compared with the final diagnoses, and compared the rate of stromal invasion between the MRI and pathological findings while focusing on surgical methods and the clinical prognosis...
2014: BMC Cancer
https://www.readbyqxmd.com/read/25284039/value-of-endocervical-margin-and-high-risk-human-papillomavirus-status-after-conization-for-high-grade-cervical-intraepithelial-neoplasia-adenocarcinoma-in-situ-and-microinvasive-carcinoma-of-the-uterine-cervix
#9
Tae-Wook Kong, Joo Hyuk Son, Suk-Joon Chang, Jiheum Paek, Yonghee Lee, Hee-Sug Ryu
OBJECTIVE: The aim of this study was to analyze clinico-pathologic factors and the optimal cut-off value of high-risk human papillomavirus (HR-HPV) viral load for predicting high-grade residual/recurrent disease after the conization in cervical intraepithelial neoplasia (CIN 2-3), adenocarcinoma in situ (AIS), and microinvasive carcinoma of the uterine cervix (MICA). METHODS: We retrospectively reviewed data from 701 patients with CIN 2-3, AIS, and MICA who underwent conization between September 2003 and June 2012...
December 2014: Gynecologic Oncology
https://www.readbyqxmd.com/read/24987910/clinical-value-of-cold-knife-conization-as-conservative-management-in-patients-with-microinvasive-cervical-squamous-cell-cancer-stage-ia1
#10
Yue He, Yu-Mei Wu, Qun Zhao, Tong Wang, Yan Wang, Wei-Min Kong, Fang Song, Wei Duan, Li Zhu, Wei-Yuan Zhang
OBJECTIVE: The aim of the study is to evaluate the clinical value of cold knife conization (CKC) as a conservative management in patients with microinvasive cervical squamous cell cancer (SCC). METHODS: This retrospective study enrolled 108 women with diagnosis of microinvasive cervical SCC (stage IA1) by pathology between 2009 to 2012 at Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Eighty-three patients underwent further hysterectomy...
September 2014: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/24949540/management-of-stage-ia1-squamous-cervical-cancer-and-the-importance-of-excision-margins-a-retrospective-study-of-long-term-outcome-after-25-years-of-follow-up
#11
Katerina Papakonstantinou, Maria Kyrgiou, Deidre Lyons, William P Soutter, Sadaf Ghaem-Maghami
OBJECTIVE: The aim of this study was to assess the effect of the excision margin after cone for stage Ia1 cervical cancer on long-term outcomes. STUDY DESIGN: Retrospective observational study. Patients were divided into 3 groups. Group A underwent immediate reflex hysterectomy; group B had cervical intraepithelial neoplasia (CIN) at the margins but were followed up; group C had clear margins. RESULTS: We identified 111 women: 19 (17.1%) in group A; 29 (26...
December 2014: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/24475583/analyses-of-atypical-glandular-cells-re-defined-by-the-2006-bethesda-system-histologic-outcomes-and-clinical-implication-of-follow-up-management
#12
V Ulker, C Numanoglu, A Akyol, O Kuru, O Akbayir, A Erim, C Ongut
BACKGROUND: To evaluate the histopathology and the long-term follow-up outcome of women who had atypical glandular cells on Pap smears. MATERIALS AND METHODS: All women with atypical glandular cells (AGC) who underwent colposcopic and histopathologic evaluation between January 2005 and October 2010 were reviewed. Patient data were examined up to October 2012, allowing for at least two years of follow-up for all patients. RESULTS: Forty-four women with AGC Pap test underwent histologic follow-up during the study period...
2013: European Journal of Gynaecological Oncology
https://www.readbyqxmd.com/read/24416999/report-of-a-pregnant-woman-underwent-radical-hysterectomy-for-cervical-cancer
#13
Ali Irfan Guzel, Emre Ozgü, Serap Akbay, Salim Erkaya, Tayfun Güngör
Cervical cancer during pregnancy has an incidence of about 1 to 10 in 10.000 individuals and is one of the most common malignancies occurring during pregnancy. In this report, we aimed to evaluate a pregnant women with cervical cancer underwent radical hysterectomy and pelvic and paraaortic lymphadenectomy at our clinic. A 47 years of pregnant woman (G8, P7) with an intrauterine pregnancy of 4 weeks 6 days of gestation admitted to our high risk pregnancy department with vaginal bleeding complaint. On vaginal examination, we detected a 4 cm of lesion protruding from the cervix...
2013: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/24262876/predictors-of-residual-carcinoma-or-carcinoma-in-situ-at-hysterectomy-following-cervical-conization-with-positive-margins
#14
Elena S Diaz, Chisa Aoyama, Mary Anne Baquing, Anna Beavis, Elvio Silva, Christine Holschneider, Ilana Cass
OBJECTIVES: Identify predictors of residual carcinoma or carcinoma-in-situ (CIS) at hysterectomy following cervical conizations with CIS and positive margins or endocervical curettage (ECC) or microinvasive cervical cancer. METHODS: Patients with cervical conization with CIS and positive margins, ECC or microinvasive carcinoma who underwent hysterectomy within 6 months of conization were identified. Conization and hysterectomy specimens were re-reviewed to assess volume of disease, ECC and margin status and residual carcinoma...
January 2014: Gynecologic Oncology
https://www.readbyqxmd.com/read/24020132/clinical-outcome-of-patients-with-microinvasive-adenocarcinoma-of-the-uterine-cervix
#15
L Meglic, R Kosir Pogacnik, S Rakar, S Smrkolj
BACKGROUND: The objective of this analysis was to present the clinical outcome of patients with microinvasive adenocarcinoma (AC) of the uterine cervix treated at the Department of Obstetrics and Gynecology between 1999 and 2010. MATERIALS AND METHODS: The authors analysed 125 patients with microinvasive AC. The analysis involved the following parameters: women's age at surgery, type of surgery, number of positive lymph nodes, and patient's survival. Additionally, a questionnaire regarding history and symptoms before diagnosis and postoperative follow-up was developed and analysed specifically for this study...
2013: European Journal of Gynaecological Oncology
https://www.readbyqxmd.com/read/23470065/management-of-abnormal-cervical-cytology-screening-in-adolescent-and-young-women-in-a-canadian-colposcopy-centre-a-descriptive-analysis
#16
Geneviève Bouchard-Fortier, Lawrence Paszat, K Joan Murphy
OBJECTIVE: To describe and analyze the management of young women referred for colposcopy at a Canadian comprehensive cancer centre for evaluation of atypical squamous intraepithelial lesion of unknown significance (ASC-US) or low-grade squamous intraepithelial lesions (LSIL). METHODS: We conducted a retrospective descriptive study by searching the eCancerCare Colposcopy Database at our centre for 15- to 29-year-old females with referral cytology of ASC-US and LSIL who were seen between January 2000 and January 2009...
February 2013: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/23324186/-cervical-microinvasive-squamous-carcinoma-during-pregnancy-observation-and-outcome-of-pregnancy-with-planned-delayed-treatment
#17
Tong Wang, Yu-mei Wu, Fang Song, Li Zhu, Xia Hao, Wei-min Kong, Wei Duan, Ling Fan, Wei-yuan Zhang
OBJECTIVE: To evaluate the maternal and fetal outcomes of planned delay in treatment for cervical microinvasive squamous cancer during pregnancy. METHODS: A prospective study of pregnant women was done from August 1, 2007 to May 31, 2010. Pregnant women who had not been carried out cervical cytological screening within one year were got thin-prep cytology test (TCT) screening at their initial prenatal visit. Patients with abnormal cytological results were performed colposcopic examination and directed biopsy...
December 2012: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/23110026/loss-of-e-cadherin-and-acquisition-of-vimentin-in-epithelial-mesenchymal-transition-are-noble-indicators-of-uterine-cervix-cancer-progression
#18
Na-Hye Myong
BACKGROUND: Epithelial-mesenchymal transition (EMT) has been known to play a key role in the stromal invasion of carcinoma in situ (CIS) lesion. Loss of E-cadherin and acquisition of vimentin are two critical steps in EMT, that are induced by Snail-1 upregulation associated with overexpression of epidermal growth factor receptor (EGFR). However, roles of EMT-related proteins in human cervical tissues have not been fully elucidated. In this study, we investigated the immunoexpressions of EMT-related proteins in CIS, microinvasive squamous cell carcinoma (SCC), and invasive SCC to demonstrate their key roles in tumor progression...
August 2012: Korean Journal of Pathology
https://www.readbyqxmd.com/read/23059885/prox-1-vegf-c-and-vegfr3-expression-during-cervical-neoplasia-progression-as-evidence-of-an-early-lymphangiogenic-switch
#19
A M Cimpean, V Mazuru, L Saptefrati, R Ceausu, M Raica
Prox1 is a key regulator of lymphatic endothelial cell commitment during embryonic development. No correlations between Prox1 and VEGF-C/VEGFR3 expression in cervical cancer has been done until now. The aim of the present study was to evaluate the peculiarities of Prox1, VEGF-C and VEGFR3 expression during uterine cervix neoplasia progression. Material and methods. One hundred and four specimens taken from women with macroscopically detectable lesions were classified by histopathology and analyzed by immunohistochemistry for Prox1, VEGFR3 and VEGF-C expression...
December 2012: Histology and Histopathology
https://www.readbyqxmd.com/read/22842126/utility-of-conization-with-frozen-section-for-intraoperative-triage-prior-to-definitive-hysterectomy
#20
MULTICENTER STUDY
Fabio Martinelli, Kathleen M Schmeler, Chelsea Johnson, Jubilee Brown, Elizabeth D Euscher, Pedro T Ramirez, Michael Frumovitz
OBJECTIVE: To review our experience with conization with intraoperative frozen section analysis and to compare results from our tertiary cancer center with those from 2 community hospitals. METHODS: The records of all women who underwent conization with intraoperative frozen section analysis from January 1, 1997, through April 30, 2011, at The University of Texas MD Anderson Cancer Center and 2 community hospitals-The Woman's Hospital of Texas and St. Luke's Episcopal Hospital-were reviewed...
November 2012: Gynecologic Oncology
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