keyword
https://read.qxmd.com/read/38271818/a-plausibility-database-summarizing-the-level-of-evidence-regarding-the-hazards-induced-by-the-exposome-on-children-health
#21
JOURNAL ARTICLE
Colzin Stacy, Crépet Amélie, Wies Blanche, Rocabois Audrey, Sanchez Margaux, Perreau Simon, Jean Julien, Redaelli Matteo, Kortenkamp Andreas, Rousselle Christophe, Vrijheid Martine, Nieuwenhuijsen Mark, Slama Rémy, Angeli Karine
Childhood diseases correspond to major public health issues. A large number of studies using different approaches provide evidence regarding effects of environmental exposures, encompassed in the exposome, on children's health. We aimed to summarize the overall level of evidence (LoE) from all streams of evidence regarding exposome effects on child health. For 88 selected chemical and urban factors, we retrieved the conclusions of agency reports or literature reviews published between 2015 and 2021 regarding effects on child health, including cardiovascular, metabolic, neurodevelopmental, respiratory and other health outcomes...
January 24, 2024: International Journal of Hygiene and Environmental Health
https://read.qxmd.com/read/38263794/liver-and-ovarian-toxicities-boosted-by-bisphenol-and-gamma-radiation-in-female-albino-rats
#22
JOURNAL ARTICLE
Asmaa A Hassan, Sherein S Abdelgayed, Somaya Z Mansour
Bisphenol A (BPA), a carbon-based synthetic polymer compound, was newly classified as an environmental toxicant and an endocrine-disrupting chemical leading to abnormalities in cell proliferation, apoptosis, or migration that contributes to cancer development and progression. This study aims to evaluate the effect of the elevation of γ- radiation dose and BPA on the liver and ovaries of female rats. In this study, eighty female albino rats (130-150 g) were used in this work. Rats in this experiment received BPA in ethanol (50 mg/kg b...
2024: Human & Experimental Toxicology
https://read.qxmd.com/read/38256048/radiation-hormesis-in-barley-manifests-as-changes-in-growth-dynamics-coordinated-with-the-expression-of-pm19l-like-cml31-like-and-aos2-like
#23
JOURNAL ARTICLE
Elizaveta Kazakova, Irina Gorbatova, Anastasia Khanova, Ekaterina Shesterikova, Ivan Pishenin, Alexandr Prazyan, Mikhail Podlutskii, Yana Blinova, Sofia Bitarishvili, Ekaterina Bondarenko, Alena Smirnova, Maria Lychenkova, Vladimir Bondarenko, Marina Korol, Daria Babina, Ekaterina Makarenko, Polina Volkova
The stimulation of growth and development of crops using ionising radiation (radiation hormesis) has been reported by many research groups. However, specific genes contributing to the radiation stimulation of plant growth are largely unknown. In this work, we studied the impact of the low-dose γ-irradiation of barley seeds on the growth dynamics and gene expression of eight barley cultivars in a greenhouse experiment. Our findings confirmed that candidate genes of the radiation growth stimulation, previously established in barley seedlings ( PM19L-like , CML31-like , and AOS2-like ), are significant in radiation hormesis throughout ontogeny...
January 12, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38242046/accelerated-fragmentation-of-two-thermoplastics-polylactic-acid-and-polypropylene-into-microplastics-after-uv-radiation-and-seawater-immersion
#24
JOURNAL ARTICLE
Zhiyue Niu, Marco Curto, Maelenn Le Gall, Elke Demeyer, Jana Asselman, Colin R Janssen, Hom Nath Dhakal, Peter Davies, Ana Isabel Catarino, Gert Everaert
To better understand the fate and assess the ingestible fraction of microplastics (by aquatic organisms), it is essential to quantify and characterize of their released from larger items under environmental realistic conditions. However, the current information on the fragmentation and size-based characteristics of released microplastics, for example from bio-based thermoplastics, is largely unknown. The goal of our work was to assess the fragmentation and release of microplastics, under ultraviolet (UV) radiation and in seawater, from polylactic acid (PLA) items, a bio-based polymer, and from polypropylene (PP) items, a petroleum-based polymer...
January 18, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38235870/effects-of-thymoquinone-in-the-lungs-of-rats-against-radiation-induced-oxidative-stress
#25
RANDOMIZED CONTROLLED TRIAL
S Doğru, S Taysi, A Yücel
OBJECTIVE: Radiotherapy is an important treatment for a wide variety of malignancies, although many cancer patients who receive radiotherapy suffer from serious side effects during and after their treatment. Thymoquinone (TQ), the main active ingredient of Nigella sativa, has been reported to have various pharmacological properties, such as antioxidant, hepatoprotective, neuroprotective, antidiabetic, anti-inflammatory, nephroprotective, anticarcinogenic in many pharmacological and toxicological studies...
January 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38231175/mass-spectral-library-for-dna-adductomics
#26
JOURNAL ARTICLE
Scott J Walmsley, Jingshu Guo, Anamary Tarifa, Anthony P DeCaprio, Marcus S Cooke, Robert J Turesky, Peter W Villalta
Endogenous electrophiles, ionizing and non-ionizing radiation, and hazardous chemicals present in the environment and diet can damage DNA by forming covalent adducts. DNA adducts can form in critical cancer driver genes and, if not repaired, may induce mutations during cell division, potentially leading to the onset of cancer. The detection and quantification of specific DNA adducts are some of the first steps in studying their role in carcinogenesis, the physiological conditions that lead to their production, and the risk assessment of exposure to specific genotoxic chemicals...
January 17, 2024: Chemical Research in Toxicology
https://read.qxmd.com/read/38216093/non-invasive-diagnosis-of-diaphragmatic-paralysis-in-botulism-using-ultrasound
#27
Issac Cheong, Mariano Iván Imbelloni, Raúl Alejandro Gómez, Federico Matías Álvarez Vilariño, Gastón Adrián Baiona, Francisco Marcelo Tamagnone
This case study explores foodborne botulism, a severe illness caused by botulinum neurotoxin-contaminated food. It leads to bilateral descending paralysis, involving the diaphragm. We highlight diaphragmatic ultrasound as a non-invasive diagnostic tool. A 50-year-old obese male developed diplopia and weakness after consuming contaminated food, rapidly progressing to severe symptoms. Mechanical ventilation became necessary due to respiratory failure. Diaphragmatic ultrasound confirmed bilateral diaphragm paralysis despite early antitoxin treatment...
February 23, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38204240/the-evolution-of-medical-imaging-in-the-therapeutics-of-patients-with-skin-cancer
#28
JOURNAL ARTICLE
Khushmeen Kaur Brar, Jeba Shiney O, Bhawna Goyal, Ayush Dogra
INTRODUCTION: Medical imaging mechanization has reformed medical management, empowering doctors to recognize cancer prematurely and promote patient outcomes. Imaging tests are of significant influence in the detection and supervision of cancer patients. Cancer recognition generally necessitates imaging studies that, in most instances, utilize a trivial amount of radiation. Methodologies such as X-rays, computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) are predominant in clinical managerial, incorporating remedy and research...
January 10, 2024: Current medical imaging
https://read.qxmd.com/read/38146151/effects-associated-with-exposure-to-the-emerging-contaminant-octyl-methoxycinnamate-a-uv-b-filter-in-the-aquatic-environment-a-review
#29
REVIEW
Margarida Lorigo, Carla Quintaneiro, Luiza Breitenfeld, Elisa Cairrao
Given the increasing concern surrounding ultraviolet (UV) radiation-induced skin damage, there has been a rise in demand for UV filters. Currently, UV-filters are considered emerging contaminants. The extensive production and use of UV filters have led to their widespread release into the aquatic environment. Thus, there is growing concern that UV filters may bioaccumulate and exhibit persistent properties within the environment, raising several safety health concerns. Octyl-methoxycinnamate (OMC) is extensively employed as a UV-B filter in the cosmetic industry...
December 25, 2023: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
https://read.qxmd.com/read/38142783/repositioning-of-fda-approved-kinase-inhibitor-bosutinib-for-mitigation-of-radiation-induced-damage-via-inhibition-of-jnk-pathway
#30
JOURNAL ARTICLE
Babita Singh, Raghavendra S Patwardhan, Debojyoti Pal, Dharmendra K Maurya, Beena Singh, Rahul Checker, Deepak Sharma, Santosh K Sandur
Radiotherapy is a common modality for cancer treatment. However, it is often associated with normal tissue toxicity in 20-80% of the patients. Radioprotectors can improve the outcome of radiotherapy by selectively protecting normal cells against radiation toxicity. In the present study, compound libraries containing 54 kinase inhibitors and 80 FDA-approved drugs were screened for radioprotection of lymphocytes using high throughput cell analysis. A second-generation FDA-approved kinase inhibitor, bosutinib, was identified as a potential radioprotector for normal cells...
December 22, 2023: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/38134636/mdm2-p53-mediate-a-mir-181c-3p-lif-axis-to-regulate-low-dose-rate-radiation-induced-dna-damage-in-human-b-lymphocytes
#31
JOURNAL ARTICLE
Yonglin Chen, Yaqi Gong, Hui Qin, Shuang Wei, Yuanyun Wei, Yueqiu Yu, Xiang Lin, Peimeng Shuai, Tiantian Wang, Caimao Guo, Qingyu Wang, Guoqing Li, Lijuan Meng, Lan Yi
PURPOSE: Prolonged exposure to low dose-rate radiation (LDRR) is of growing concern to public health. Recent evidences indicates that LDRR causes deleterious health effects and is closely related to miRNAs. The aim of our study is to investigate the relationship between miRNAs and DNA damage caused by LDRR. MATERIALS AND METHODS: In this study, we irradiated C57BL/6J mice with 12.5μGy/h dose of γ ray emitted from uranium ore for 8 h a day for 120 days at a total dose of 12 mGy, and identified differentially expressed miRNAs from the mice long-term exposed to LDRR through isolating serum RNAs, constructing small RNA library, Illumina sequencing...
December 21, 2023: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38133205/cytotoxicity-and-radiosensitizing-potentials-of-pilosulin-3-a-recombinant-ant-venom-in-breast-cancer-cells
#32
JOURNAL ARTICLE
Reema M Alzeer, Khaled S Al-Hadyan, Najla M Al-Harbi, Sara S Bin Judia, Rafa S Almeer, Ghazi A Alsbeih
Venom peptides are promising agents in the development of unconventional anticancer therapeutic agents. This study explored the potential of Pilosulin-3, a recombinant peptide from the venom of the Australian jack jumper ant " Myrmecia pilosula ", as a cytotoxic and radiosensitizing agent in MCF-7 and MDA-MB-231 breast cancer (BC) cell lines. Pilosulin-3's cytotoxicity was evaluated across a wide range of concentrations using a proliferation assay. Cell cycle progression and apoptosis were examined at the inhibitory concentration 25% (IC25) and IC50 of Pilosulin-3, both with and without a 4Gy X-ray irradiation dose...
December 15, 2023: Toxins
https://read.qxmd.com/read/38133193/botulinum-toxin-treatment-for-cancer-related-disorders-a-systematic-review
#33
REVIEW
Delaram Safarpour, Bahman Jabbari
This systematic review investigates the effect of botulinum neurotoxin (BoNT) therapy on cancer-related disorders. A major bulk of the literature is focused on BoNT's effect on pain at the site of surgery or radiation. All 13 published studies on this issue indicated reduction or cessation of pain at these sites after local injection of BoNTs. Twelve studies addressed the effect of BoNT injection into the pylorus (sphincter between the stomach and the first part of the gut) for the prevention of gastroparesis after local resection of esophageal cancer...
December 8, 2023: Toxins
https://read.qxmd.com/read/38068543/selected-exogenous-occupational-and-environmental-risk-factors-for-cardiovascular-diseases-in-military-and-aviation
#34
REVIEW
Ewelina Maculewicz, Agata Pabin, Łukasz Dziuda, Małgorzata Białek, Agnieszka Białek
Cardiovascular diseases are a group of disorders of heart and blood vessels which are the leading cause of death globally. They are also a very important cause of military unsuitability especially among military pilots. Some of the risk factors cannot be modified, but a large group of them can be modified by introducing healthy habits or behaviors, such as regular physical activity, quitting of tobacco smoking, cessation of harmful alcohol consumption, or stress avoidance. Specific occupational and environmental factors, such as acceleration, pressure changes, hypoxia, thermal stress, noise, vibration, prolonged sedentary posture, difficulties in moving the limbs, shifts, work shift irregularities, circadian dysrhythmia, variations in the microclimate, motion sickness, radiation, toxicological threats, occupational stress, emotional tension, highly demanding tasks especially during take-off and landing, predominance of intellectual over physical activity, and forced operation speed against time shortage are considered as characteristic for military personnel, especially military aircrews...
December 4, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/38060292/a-systematic-review-and-meta-analysis-of-radon-risk-exposure-from-drinking-water-resources-in-nigeria
#35
REVIEW
Adamu Usman Mohammed, Ahmad Zaharin Aris, Mohammad Firuz Ramli, Noorain Mohd Isa, Abdullahi Suleiman Arabi, Muyiwa Michael Orosun
Elevated radon concentrations in drinking water pose an increased risk of cancer among nonsmokers. A Monte-Carlo Simulation was employed to assess the effective dose and cancer risk associated with radon exposure in humans, utilizing a systematic review and meta-analysis of related studies. These studies were sourced from databases including PubMed, Web of Science, Scopus, Science Direct, and Google Scholar, focusing on drinking water from Nigeria's six geopolitical zones. The random effects models revealed a 222 Rn concentration in drinking water of Nigeria at 25...
December 7, 2023: Journal of environmental science and health. Part C, Toxicology and carcinogenesis
https://read.qxmd.com/read/38059131/network-pharmacology-and-bioinformatics-to-identify-the-molecular-mechanisms-of-gleditsiae-spina-against-colorectal-cancer
#36
JOURNAL ARTICLE
Yingzi Wu, Jinhai Luo, Baojun Xu
OBJECTIVE: In this study, network pharmacology, bioinformatics and molecular docking were used to explore the active phytochemicals, hub genes, and potential molecular mechanisms of Gleditsiae Spina in treating of colorectal cancer.. METHODS: The targets of Gleditsiae Spina, and targets related to CRC were derived from databases. We identified the hub genes for Gleditsiae Spina anti-colorectal cancer following the protein-protein-interaction (PPI) network. Furthermore, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment were used to analyze the hub genes from a macro perspective...
2023: Current research in toxicology
https://read.qxmd.com/read/38037166/radiation-exposure-doses-to-the-surgical-team-during-hip-surgery-is-significantly-higher-during-lateral-imaging-than-posteroanterior-imaging-a-cadaveric-simulation-study
#37
JOURNAL ARTICLE
Yasuaki Tamaki, Kazuta Yamashita, Daiki Nakajima, Yasuyuki Omichi, Yoshinori Takahashi, Michihiro Takai, Shunsuke Tamaki, Tomohiro Goto, Hiroaki Hayashi, Kosaku Higashino, Yoshihiro Tsuruo, Koichi Sairyo
BACKGROUND: Fluoroscopy is indispensable when determining appropriate and effective interventions in orthopedic surgery. On the other hand, there is growing concern about the health hazards of occupational radiation exposure. The aim of this cadaveric simulation study was to measure radiation exposure doses to the surgical team during hip surgery. METHODS: We reproduced the intraoperative setting of hip surgery using 7 fresh frozen cadavers (5 male, 2 female) to simulate patients and mannequins to simulate the surgeon, scrub nurse, and anesthesiologist...
November 30, 2023: Journal of Occupational Medicine and Toxicology
https://read.qxmd.com/read/38036231/arsenic-and-uvr-co-exposure-results-in-unique-gene-expression-profile-identifying-key-co-carcinogenic-mechanisms
#38
JOURNAL ARTICLE
Rachel M Speer, Hui Yu, Xixi Zhou, Shuvro Nandi, Ludmil Alexandrov, Yan Guo, Laurie G Hudson, Ke Jian Liu
Changes in gene expression underlie many pathogenic endpoints including carcinogenesis. Metals, like arsenic, alter gene expression; however, the consequences of co-exposures of metals with other stressors are less understood. Although arsenic acts as a co-carcinogen by enhancing the development of UVR skin cancers, changes in gene expression in arsenic UVR co-carcinogenesis have not been investigated. We performed RNA-sequencing analysis to profile changes in gene expression distinct from arsenic or UVR exposures alone...
November 28, 2023: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/38036073/phototoxic-action-of-meloxicam-contributes-to-dysregulation-of-redox-homeostasis-in-normal-human-skin-cells-molecular-and-biochemical-analysis-of-antioxidant-enzymes-in-melanocytes-and-fibroblasts
#39
JOURNAL ARTICLE
Marta Karkoszka, Jakub Rok, Justyna Kowalska, Zuzanna Rzepka, Klaudia Banach, Dorota Wrześniok
The phototoxic effect of meloxicam (MLX) raises the question of the effect of the drug on the redox homeostasis of normal human skin cells. The main objective of the study was to analyze the effect of MLX and/or UVA radiation (UVAR) on the redox homeostasis of human normal skin cells - melanocytes and fibroblasts. MLX was found to affect the activity and expression of enzymes of the antioxidant system differently depending on the cell line used. The drug decreased the activity and expression of superoxide dismutase type 1 and 2 (SOD1 and SOD2), catalase (CAT) and glutathione peroxidase (GPx) in fibroblasts, while increasing the activity of these enzymes in melanocytes...
November 28, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/37984482/applications-of-premature-chromosome-condensation-technique-for-genetic-analysis
#40
REVIEW
C H Anjali, Ravi Maddaly
Cytogenetic techniques are used to detect aberrations in the genetic material and such techniques have a wide range of applications including for disease diagnosis, drug discovery and for the detection and quantification of mutagenic exposures. Although different types of cytogenetic techniques are in use, the Premature Chromosome Condensation (PCC) is one which is unique by virtue of it not requiring culture of peripheral blood mononucleate cells (PBMNCs) to detect chromatid and chromosomal aberrations. Such an advantage is useful in situations where rapid assessments of genetic damage is required, for example, during radiation exposures...
November 18, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
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