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https://www.readbyqxmd.com/read/29668140/-standardization-of-a-multiplex-real-time-pcr-test-for-the-identification-of-angiostrongylus-cantonensis-a-costaricensis-and-a-vasorum
#1
Rubén E Varela-M, Jinney Stefany Arias, Luz Elena Velásquez
INTRODUCTION: Angiostrongyliasis is a disease caused by Angiostrongylus nematodes that is present worldwide. The infections with the highest impact on human and animal health are caused by A. cantonensis, A. costaricensis, and A. vasorum. Clinical forms of the disease in humans are eosinophilic meningitis and abdominal angiostrongyliasis, while the most common effect on dogs are cardiopulmonary damages. It is deemed as an emerging disease as the result of the global dissemination of the African snail Lissachatina fulica, an intermediary host of these parasites...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29667889/journal-club-the-warthin-tumor-score-a-simple-and-reliable-method-to-distinguish-warthin-tumors-from-pleomorphic-adenomas-and-carcinomas
#2
Chih-Wei Wang, Yueng-Hsiang Chu, Deng-Yiv Chiu, Nieh Shin, Hsian-He Hsu, Jih-Chin Lee, Chun-Jung Juan
OBJECTIVE: The objective of this article is to propose a Warthin tumor (WT) score to distinguish WTs from other parotid tumors. MATERIALS AND METHODS: The study included 78 patients with 92 histologically proven parotid tumors, including 42 WTs, 30 pleomorphic adenomas (PMAs), and 20 carcinomas. Echo-planar DW images were acquired. The WT score, which comprised the mean apparent diffusion coefficient (ADCM ) and the SD of the ADC (ADCSD ) of tumors, patient age, and patient sex, was used to predict WTs...
April 18, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29667884/egg-and-banana-sign-a-novel-diagnostic-ct-marker-for-pulmonary-hypertension
#3
Chris L Scelsi, William B Bates, Yulia V Melenevsky, Gyanendra K Sharma, Norman B Thomson, Jayanth H Keshavamurthy
OBJECTIVE: The purpose of this study was to retrospectively determine whether the egg-and-banana sign, defined as the visualization of the main pulmonary artery (PA) at the level of the aortic arch, is a sensitive and specific diagnostic marker for pulmonary hypertension. MATERIALS AND METHODS: A total of 186 patients who, between January 2014 and July 2017, received right heart catheterizations and underwent CT studies that included the aortic arch within 140 days of catheterization were evaluated in this retrospective study...
April 18, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29667880/motion-artifacts-lesion-type-and-parenchymal-enhancement-in-breast-mri-what-does-really-influence-diagnostic-accuracy
#4
Paola Clauser, Matthias Dietzel, Michael Weber, Clemens G Kaiser, Pascal At Baltzer
Background Motion artifacts can reduce image quality of breast magnetic resonance imaging (MRI). There is a lack of data regarding their effect on diagnostic estimates. Purpose To evaluate factors that potentially influence readers' diagnostic estimates in breast MRI: motion artifacts; amount of fibroglandular tissue; background parenchymal enhancement; lesion size; and lesion type. Material and Methods This Institutional Review Board-approved, retrospective, cross-sectional, single-center study included 320 patients (mean age = 55...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29667143/diagnostic-performance-of-18-f-fdg-pet-ct-and-whole-body-diffusion-weighted-imaging-with-background-body-suppression-dwibs-in-detection-of-lymph-node-and-bone-metastases-from-pediatric-neuroblastoma
#5
Hiroaki Ishiguchi, Shinji Ito, Katsuhiko Kato, Yusuke Sakurai, Hisashi Kawai, Naotoshi Fujita, Shinji Abe, Atsushi Narita, Nobuhiro Nishio, Hideki Muramatsu, Yoshiyuki Takahashi, Shinji Naganawa
OBJECTIVE: Recent many studies have shown that whole body "diffusion-weighted imaging with background body signal suppression" (DWIBS) seems a beneficial tool having higher tumor detection sensitivity without ionizing radiation exposure for pediatric tumors. In this study, we evaluated the diagnostic performance of whole body DWIBS and 18 F-FDG PET/CT for detecting lymph node and bone metastases in pediatric patients with neuroblastoma. METHODS: Subjects in this retrospective study comprised 13 consecutive pediatric patients with neuroblastoma (7 males, 6 females; mean age, 2...
April 17, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29666994/whole-body-mri-in-spondyloarthritis-spa-preliminary-results-suggest-that-dwi-outperforms-stir-for-lesion-detection
#6
Frederic E Lecouvet, Nicolas Vander Maren, Laurence Collette, Nicolas Michoux, Perrine Triqueneaux, Maria Stoenoiu, Frederic Houssiau, Jacques Malghem, Marie-Laurence Denis, Ahmed Larbi, Adrien Nzeusseu Toukap
PURPOSE: To compare the diagnostic accuracy of DWI and STIR sequences in Whole body (WB) MRI of SpA patients. MATERIALS AND METHODS: Twenty consecutive patients with confirmed active SpA and 20 controls were investigated with identical WB MRI protocols, including DWI and STIR images. Two observers recorded 'lesions' (high signal intensity foci on STIR and high b-value DWI) in 17 anatomical areas, making a 17-point 'area score' and a 40-point 'lesion score'. ROC performance, inter-observer agreement, correlation with clinical parameters and spine and sacro-iliac joints (SIJ) MRI scores were assessed...
April 17, 2018: European Radiology
https://www.readbyqxmd.com/read/29666966/point-of-care-lung-ultrasound-for-diagnosis-of-pneumocystis-jirovecii-pneumonia-notes-from-the-field
#7
Maria Teresa Giordani, Francesca Tamarozzi, Daniel Kaminstein, Enrico Brunetti, Tom Heller
BACKGROUND: Thoracic ultrasound is helpful to evaluate lung pathology in patients with acute dyspnea. Several studies have demonstrated the efficacy of point-of-care ultrasound in patients with extrapulmonary TB and HIV co-infection. This retrospective, open-label case-control study explores the role of lung ultrasound in the diagnosis of Pneumocystis jirovecii pneumonia (PJP) in HIV-positive patients. In particular, it highlights the potential role of specific sonographic features that may be unique to this population...
April 17, 2018: Critical Ultrasound Journal
https://www.readbyqxmd.com/read/29666952/utility-of-diffusion-weighted-mr-imaging-in-the-diagnosis-of-placenta-accreta-spectrum-abnormality
#8
Bhagya Sannananja, Anna Ellermeier, Daniel S Hippe, Thomas C Winter, Stella K Kang, Susanna I Lee, Mark R Kilgore, Manjiri K Dighe
PURPOSE: The aim of this study was to evaluate the utility of added DWI sequences as an adjunct to traditional MR imaging in the evaluation of abnormal placentation in patients with suspicion for placenta accreta spectrum abnormality or morbidly adherent placenta (MAP). MATERIALS AND METHODS: The study was approved by local ethics committee. The subjects included pregnant women with prenatal MRI performed between July 2013 to July 2015. All imaging was performed on a Philips 1...
April 17, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29666668/prospective-real-time-evaluation-of-diagnostic-performance-using-endocytoscopy-in-differentiating-neoplasia-from-non-neoplasia-for-colorectal-diminutive-polyps-%C3%A2-5-mm
#9
Takahiro Utsumi, Yasushi Sano, Mineo Iwatate, Hironori Sunakawa, Akira Teramoto, Daizen Hirata, Santa Hattori, Wataru Sano, Noriaki Hasuike, Kazuhito Ichikawa, Takahiro Fujimori
AIM: To clarify the diagnostic performance of endocytoscopy for differentiation between neoplastic and non-neoplastic colorectal diminutive polyps. METHODS: Patients who underwent endocytoscopy between October and December 2016 at Sano Hospital were prospectively recruited. When diminutive polyps (≤ 5 mm) were detected, the lesions were evaluated by endocytoscopy after being stained with 0.05% crystal violet and 1% methylene blue. The diminutive polyps were classified into five categories (EC 1a, 1b, 2, 3a, and 3b)...
April 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29666413/texture-analysis-and-support-vector-machine-assisted-diffusional-kurtosis-imaging-may-allow-in-vivo-gliomas-grading-and-idh-mutation-status-prediction-a-preliminary-study
#10
Sotirios Bisdas, Haocheng Shen, Steffi Thust, Vasileios Katsaros, George Stranjalis, Christos Boskos, Sebastian Brandner, Jianguo Zhang
We sought to investigate, whether texture analysis of diffusional kurtosis imaging (DKI) enhanced by support vector machine (SVM) analysis may provide biomarkers for gliomas staging and detection of the IDH mutation. First-order statistics and texture feature extraction were performed in 37 patients on both conventional (FLAIR) and mean diffusional kurtosis (MDK) images and recursive feature elimination (RFE) methodology based on SVM was employed to select the most discriminative diagnostic biomarkers. The first-order statistics demonstrated significantly lower MDK values in the IDH-mutant tumors...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29666295/lung-ultrasound-prior-to-spontaneous-breathing-trial-is-not-helpful-in-weaning-the-decision-making-process
#11
Ana Carolina P Antonio, Marli M Knorst, Cassiano Teixeira
BACKGROUND: Lung ultrasound is increasingly becoming a diagnostic tool in the critical care setting. B-pattern on a lung ultrasound is an artifact composed of multiple B-lines and correlates with interstitial edema. A randomized controlled trial concluded that bedside thoracic ultrasound could predict postextubation distress through changes in lung aeration during a weaning procedure; however, it could not screen patients before performance of a spontaneous breathing trial (SBT). METHODS: We conducted a 2-year, prospective, multicenter, observational study in 2 adult medical-surgical ICUs in southern Brazil...
April 17, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29665853/microsatellite-instability-in-prostate-cancer-by-pcr-or-next-generation-sequencing
#12
Jennifer A Hempelmann, Christina M Lockwood, Eric Q Konnick, Michael T Schweizer, Emmanuel S Antonarakis, Tamara L Lotan, Bruce Montgomery, Peter S Nelson, Nola Klemfuss, Stephen J Salipante, Colin C Pritchard
BACKGROUND: Microsatellite instability (MSI) is now being used as a sole biomarker to guide immunotherapy treatment for men with advanced prostate cancer. Yet current molecular diagnostic tests for MSI have not been evaluated for use in prostate cancer. METHODS: We evaluated two next-generation sequencing (NGS) MSI-detection methods, MSIplus (18 markers) and MSI by Large Panel NGS (> 60 markers), and compared the performance of each NGS method to the most widely used 5-marker MSI-PCR detection system...
April 17, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29665748/low-or-undetectable-basal-thyroglobulin-levels-obviate-the-need-for-neck-ultrasound-in-differentiated-thyroid-cancer-patients-after-total-thyroidectomy-and-i-131-ablation
#13
Frederik Verburg, Uwe Maeder, Luca Giovanella, Markus Luster, Christoph Reiners
BACKGROUND: Neck ultrasound (NUS) is currently seen as a main component of follow-up of differentiated thyroid cancer (DTC) and is usually performed regardless of non-stimulated thyroglobulin (Tg) levels. The aim of this study is to determine whether there is a clinical benefit from such a routine NUS in DTC patients. METHODS: We performed a retrospective database study of 3176 cervical ultrasound exams performed in 773 patients between June 15, 1996 and July 1, 2012...
April 18, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29665706/the-efficacy-of-using-computer-aided-detection-cad-for-detection-of-breast-cancer-in-mammography-screening-a-systematic-review
#14
Emilie L Henriksen, Jonathan F Carlsen, Ilse Mm Vejborg, Michael B Nielsen, Carsten A Lauridsen
Background Early detection of breast cancer (BC) is crucial in lowering the mortality. Purpose To present an overview of studies concerning computer-aided detection (CAD) in screening mammography for early detection of BC and compare diagnostic accuracy and recall rates (RR) of single reading (SR) with SR + CAD and double reading (DR) with SR + CAD. Material and Methods PRISMA guidelines were used as a review protocol. Articles on clinical trials concerning CAD for detection of BC in a screening population were included...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29665696/nosographic-analysis-of-osmophobia-and-field-testing-of-diagnostic-criteria-including-osmophobia
#15
Mona Ameri Chalmer, Thomas Folkmann Hansen, Jes Olesen
Introduction Osmophobia has been suggested as an additional symptom of migraine without aura, and a high prevalence of osmophobia of up to 50% has been reported in the literature. We conducted a nosographic study of osmophobia in all migraineurs and tension-type headache patients and a field testing of suggested diagnostic criteria of osmophobia, presented in the appendix of the second edition of The International Classification of Headache Disorders and suggested by Silva-Néto et al. and Wang et al ., in migraine without aura and tension-type headache patients (n = 1934)...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29665574/diagnostic-methods-to-detect-uterus-illnesses-in-mares
#16
Miguel Alejandro Silva Rua, Celia Raquel Quirino, Rachel Bittencourt Ribeiro, Eulogio Carlos Queiroz Carvalho, Maria de Lourdes Amaral Bernadino, Aylton Bartholazzi Junior, Luisa Fernanda Cipagalta, Marcus Antônio Pessanha Barreto
Uterine illnesses are the major problem in horse reproductive programs. The diagnosis of these pathologies is often neglected or does not provide enough information about the cause. The aim of this study was to evaluate different diagnoses to provide more accurate information about endometritis and the real endometrial profile at the beginning of a breeding season. Fifty-one mares with reproductive failure were evaluated. Two different uterine cytology diagnoses, culture of uterine flush material and biopsy assay, were performed...
April 9, 2018: Theriogenology
https://www.readbyqxmd.com/read/29665344/sepsis-diagnostics-in-the-era-of-omics-technologies
#17
REVIEW
Miroslav Průcha, Roman Zazula, Stefan Russwurm
Sepsis is a multifactorial clinical syndrome with an extremely dynamic clinical course and with high diverse clinical phenotype. Early diagnosis is crucial for the final clinical outcome. Previous studies have not identified a biomarker for the diagnosis of sepsis which would have sufficient sensitivity and specificity. Identification of the infectious agents or the use of molecular biology, next gene sequencing, has not brought significant benefit for the patient in terms of early diagnosis. Therefore, we are currently searching for biomarkers, through "omics" technologies with sufficient diagnostic specificity and sensitivity, able to predict the clinical course of the disease and the patient response to therapy...
2018: Prague Medical Report
https://www.readbyqxmd.com/read/29665324/rapid-amplification-of-prions-from-variant-creutzfeldt-jakob-disease-cerebrospinal-fluid
#18
Marcelo A Barria, Andrew Lee, Alison Je Green, Richard Knight, Mark W Head
Human prion diseases constitute a group of infectious and invariably fatal neurodegenerative disorders associated with misfolding of the prion protein. Variant Creutzfeldt-Jakob disease (vCJD) is a zoonotic prion disease linked to oral exposure to the infectious agent that causes bovine spongiform encephalopathy (BSE) in cattle. The most recent case of definite vCJD was heterozygous (MV) at polymorphic codon 129 of the prion protein gene PRNP while all of the previous 177 definite or probable vCJD cases who underwent genetic analysis were methionine homozygous (MM)...
April 2018: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/29664550/maternal-placi-protein-levels-in-early-and-late-onset-preeclampsia
#19
Mujde Can Ibanoglu, A Seval Ozgu-Erdinc, Dilek Uygur
OBJECTIVES: The objective of this study was to determine the maternal PLAC1 protein levels in early and late onset preec-lampsia. MATERIAL AND METHODS: A total of 135 pregnant women were included in the study, of which 55 were at < 34 weeks of gesta-tion and 80 were at ≥ 34 weeks of gestation, between June and November 2014 were recruited in this case control study. RESULTS: Analysis of maternal serum PLAC1 levels did not reveal any significant differences between early onset PE and controls (p = 0...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29664355/fibulin-3-immunoexpression-in-malignant-mesothelioma-due-to-fluoro-edenite-a-preliminary-report
#20
Rosario Caltabiano, Carla Loreto, Ermanno Vitale, Serena Matera, Edoardo Miozzi, Marcello Migliore, Giuseppe Angelico, Rosario Tumino, Caterina Ledda, Venerando Rapisarda
An increased standardized incidence and mortality rate were reported due to malignant mesothelioma (MM) in Biancavilla. Environmental investigations showed the presence of an asbestiform fiber: fluoro-edenite (FE). MM develops with a latency of 20-60 years from exposure and specific and sensitive biomarkers are urgently needed. For this purpose, we evaluated Fibulin-3 (Fb-3) immunoexpression in human cases of MM related to FE exposure and its prognostic role. Immunohistochemical analysis of Fb-3 was carried out in eight MM patients resident in Biancavilla and the analysis showed evidence of environmental exposure to FE fibers...
March 2018: Future Oncology
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