keyword
https://read.qxmd.com/read/35079875/effects-of-matcha-tea-extract-on-cell-viability-and-peroxisome-proliferator-activated-receptor-%C3%AE-expression-on-t47d-breast-cancer-cells
#21
JOURNAL ARTICLE
Simon Keckstein, Constantin Tilgener, Udo Jeschke, Simone Hofmann, Theresa Vilsmaier, Till Kaltofen, Helene Heidegger, Falk Batz, Sven Mahner, Lennard Schröder
PURPOSE: In the following work, we investigated the nuclear peroxisome proliferator-activated receptor gamma (PPARγ)-dependent proliferation behavior of breast cancer cells after stimulation with matcha green tea extract (MTE). METHODS: T47D cells were stimulated with MTE at concentrations of 5, 10 and 50 µg/ml. Cell viability was assessed using a WST-1 assay after an incubation time of 72 h. PPARγ expression was quantified at the gene level by real-time polymerase chain reaction (PCR)...
January 25, 2022: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/35026095/what-to-choose-and-why-to-use-a-critical-review-on-the-clinical-relevance-of-rasrm-efi-and-enzian-classifications-of-endometriosis
#22
JOURNAL ARTICLE
G Hudelist, L Valentin, E Saridogan, G Condous, M Malzoni, H Roman, D Jurkovic, J Keckstein
Background: Endometriosis is a common benign gynaecological disease that affects pelvic structures and causes adhesions. Endometriosis outside the pelvis exists but is rarer. Deep endometriosis may affect organs such as the urinary bladder, ureters, bowel and sacral roots. Adenomyosis (growth of endometrium in the myometrium, sometimes explained by disruption of the uterine junctional zone) frequently co-exists with deep endometriosis. Over the past decades, multiple attempts have been made to describe the anatomical extent of endometriosis...
December 2021: Facts, Views & Vision in ObGyn
https://read.qxmd.com/read/34919760/accuracy-of-sonography-for-non-invasive-detection-of-ovarian-and-deep-endometriosis-using-enzian-classification-prospective-multicenter-diagnostic-accuracy-study
#23
MULTICENTER STUDY
E Montanari, A Bokor, G Szabó, W Kondo, C H Trippia, M Malzoni, A Di Giovanni, H R Tinneberg, A Oberstein, R M Rocha, M Leonardi, G Condous, H Alsalem, J Keckstein, G Hudelist
OBJECTIVE: To compare the preoperative detection of endometriosis using transvaginal sonography (TVS) supplemented by transabdominal sonography (TAS) with surgical assessment of disease, using the #Enzian classification for endometriosis. METHODS: This was a prospective multicenter diagnostic accuracy study of women undergoing TVS/TAS and radical surgery for deep endometriosis (DE) at different tertiary referral centers. The localization and grade of severity of the endometriotic lesions and adhesions were described according to the criteria of the #Enzian classification, both at preoperative ultrasound examination and during surgery...
March 2022: Ultrasound in Obstetrics & Gynecology
https://read.qxmd.com/read/34359656/cytoplasmic-localization-of-rxr%C3%AE-determines-outcome-in-breast-cancer
#24
JOURNAL ARTICLE
Alaleh Zati Zehni, Falk Batz, Vincent Cavaillès, Sophie Sixou, Till Kaltofen, Simon Keckstein, Helene Hildegard Heidegger, Nina Ditsch, Sven Mahner, Udo Jeschke, Theresa Vilsmaier
The aim of this retrospective study was to assess the prognostic value of cytoplasmic versus nuclear RXRα expression in breast cancer (BC) tissue samples and to correlate the results with clinicopathological parameters. In 319 BC patients, the expression of RXRα was evaluated via immunohistochemistry. Prognosis-determining aspects were calculated through uni- and multivariate analyses. Correlation analysis revealed a trend association with nuclear RXRα expression regarding an improved overall survival (OS) ( p = 0...
July 26, 2021: Cancers
https://read.qxmd.com/read/34283076/identification-of-a-novel-tumor-microenvironment-prognostic-signature-for-advanced-stage-serous-ovarian-cancer
#25
JOURNAL ARTICLE
Mingjun Zheng, Junyu Long, Anca Chelariu-Raicu, Heather Mullikin, Theresa Vilsmaier, Aurelia Vattai, Helene Hildegard Heidegger, Falk Batz, Simon Keckstein, Udo Jeschke, Fabian Trillsch, Sven Mahner, Till Kaltofen
(1) Background: The tumor microenvironment is involved in the growth and proliferation of malignant tumors and in the process of resistance towards systemic and targeted therapies. A correlation between the gene expression profile of the tumor microenvironment and the prognosis of ovarian cancer patients is already known. (2) Methods: Based on data from The Cancer Genome Atlas (379 RNA sequencing samples), we constructed a prognostic 11-gene signature ( SNRPA1 , CCL19 , CXCL11 , CDC5L , APCDD1 , LPAR2 , PI3 , PLEKHF1 , CCDC80 , CPXM1 and CTAG2 ) for Fédération Internationale de Gynécologie et d'Obstétrique stage III and IV serous ovarian cancer through lasso regression...
July 3, 2021: Cancers
https://read.qxmd.com/read/34242934/structured-report-for-dynamic-ultrasonography-in-patients-with-suspected-or-known-endometriosis-recommendations-of-the-international-society-for-gynecologic-endoscopy-isge
#26
REVIEW
Dusan Djokovic, Patrícia Pinto, Bruno J van Herendael, Antonio Simone Laganà, Viju Thomas, Jörg Keckstein
OBJECTIVE: The International Society for Gynecologic Endoscopy (ISGE) developed this project to establish the recommendations for structured reporting of dynamic ultrasound findings, promoting on this manner the practice of standardized, comprehensive and systematic evaluation and reporting of endometriosis in pelvic structures, in correlation with the #Enzian classification. STUDY DESIGN: A non-systematic review was done through a search on the following databases: MEDLINE, EMBASE, Global Health, The Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Cochrane Methodology Register), Health Technology Assessment Database and Web of Science, using the medical subject heading (MeSH) term "endometriosis" (MeSH Unique ID: D004715) in combination with "diagnostic imaging" (MeSH Unique ID Q000000981) and "consensus" (MeSH Unique ID D032921)...
August 2021: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/34101746/well-being-during-covid-19-pandemic-a-comparison-of-individuals-with-minoritized-sexual-and-gender-identities-and-cis-heterosexual-individuals
#27
JOURNAL ARTICLE
Pichit Buspavanich, Sonia Lech, Eva Lermer, Mirjam Fischer, Maximilian Berger, Theresa Vilsmaier, Till Kaltofen, Simon Keckstein, Sven Mahner, Joachim Behr, Christian J Thaler, Falk Batz
BACKGROUND: Preliminary empirical data indicates a substantial impact of the COVID-19 pandemic on well-being and mental health. Individuals with minoritized sexual and gender identities are at a higher risk of experiencing such negative changes in their well-being. The objective of this study was to compare levels of well-being among cis-heterosexual individuals and individuals with minoritized sexual and gender identities during the COVID-19 pandemic. METHODS: Using data obtained in a cross-sectional online survey between April 20 to July 20, 2020 (N = 2332), we compared levels of well-being (WHO-5) across subgroups (cis-individuals with minoritized sexual identities, individuals with minoritized gender identities and cis-heterosexual individuals) applying univariate (two-sample t-test) and multivariate analysis (multivariate linear regression)...
2021: PloS One
https://read.qxmd.com/read/33984522/prevalence-of-endometriosis-and-peritoneal-pockets-in-women-with-infertility-and-or-pelvic-pain
#28
JOURNAL ARTICLE
Philippe R Koninckx, Anastasia Ussia, Jörg Keckstein, Leila Adamyan, Arnaud Wattiez, Daniel C Martin
OBJECTIVE: To evaluate the prevalence of endometriosis and peritoneal pockets and to analyze whether these pockets are associated with pain. METHODS: Analysis of prospectively registered data of all women undergoing laparoscopy for infertility or pelvic pain between 1988 and 2011 at KU Leuven University Hospital. RESULTS: Of 4497 women, 191 had 238 pockets, with a prevalence of 4.7% in women with infertility only, 4.9% in women with infertility and pelvic pain, and 3...
May 10, 2021: Journal of Obstetrics and Gynaecology Canada: JOGC
https://read.qxmd.com/read/33582378/comparison-between-sonography-based-and-surgical-extent-of-deep-endometriosis-using-the-enzian-classification-a-prospective-diagnostic-accuracy-study
#29
JOURNAL ARTICLE
Gernot Hudelist, Eliana Montanari, Mohamed Salama, Bernhard Dauser, Zoltan Nemeth, Joerg Keckstein
STUDY OBJECTIVE: To compare a preoperative evaluation of deep endometriosis (DE) by transvaginal sonography (TVS) according to the Enzian classification with the intraoperatively assessed extent of DE using the Enzian system. DESIGN: Prospective diagnostic accuracy study. SETTING: Tertiary referral center for endometriosis. PATIENTS: Women undergoing TVS and surgery for DE between 2017 and 2019 (N = 195). INTERVENTIONS: Evaluation of DE lesion sizes according to the Enzian classification as evaluated by preoperative TVS compared with surgical findings...
September 2021: Journal of Minimally Invasive Gynecology
https://read.qxmd.com/read/33575675/preoperative-imaging-of-deep-endometriosis-pitfalls-of-a-diagnostic-test-before-surgery
#30
JOURNAL ARTICLE
P R Koninckx, A Deslandes, A Ussia, A Di Giovanni, G Hanan, M Tahlak, L Adamian, J Keckstein, A Wattiez
The usefulness of a test is determined by the clinical interpretation of its sensitivity and specificity. The pitfalls of a test with a surgical endpoint are described in this article, taking the diagnosis of deep endometriosis by imaging as an example, without discussing the management of deep endometriosis. Laparoscopy is not a 100% accurate "gold standard". Since it is not performed in women without symptoms, results are valid only for the group of women as specified in the indication for surgery...
January 8, 2021: Facts, Views & Vision in ObGyn
https://read.qxmd.com/read/33558167/classification-of-deep-endometriosis-de-including-bowel-endometriosis-from-r-asrm-to-enzian-classification
#31
REVIEW
Jörg Keckstein, Gernot Hudelist
Endometriotic lesions may affect peritoneal and ovarian tissues, cause secondary adhesions, and - in case of deep endometriosis (DE), invade organs such as the urinary bladder, ureters, and bowel. Over decades, several classification systems have been proposed with the rASRM score being the most widely accepted one to date. However, the rASRM classification has certain limitations regarding the description of DE. In contrast, the Enzian classification, which has been updated and modified recently in the form of the so-called #Enzian classification, has proved to be the most suitable tool for staging DE and now also includes peritoneal or ovarian diseases as well as adhesions...
March 2021: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://read.qxmd.com/read/33545613/interleukin-1-beta-is-significantly-upregulated-in-the-decidua-of-spontaneous-and-recurrent-miscarriage-placentas
#32
JOURNAL ARTICLE
Sanja Löb, Niklas Amann, Christina Kuhn, Elisa Schmoeckel, Achim Wöckel, Alaleh Zati Zehni, Till Kaltofen, Simon Keckstein, Jan-Niclas Mumm, Sarah Meister, Thomas Kolben, Sven Mahner, Udo Jeschke, Theresa Vilsmaier
BACKGROUND: Pregnancy is an extraordinarily complex immunological process. For successful pregnancy maintenance the maternal immune system must adapt to and tolerate the semi-allogenic fetus at the fetomaternal interface of the placenta. This balance is regulated by cytokines with a predominant T helper 2 (Th-2) system and a suppressed inflammatory T helper 1 (Th-1) response. This study investigates the role of the Th-1 pro-inflammatory cytokine Interleukin-1 beta (IL-1β) and its role in early pregnancy loss...
April 2021: Journal of Reproductive Immunology
https://read.qxmd.com/read/33483970/the-enzian-classification-a-comprehensive-non-invasive-and-surgical-description-system-for-endometriosis
#33
JOURNAL ARTICLE
Jörg Keckstein, Ertan Saridogan, Uwe A Ulrich, Martin Sillem, Peter Oppelt, Karl W Schweppe, Harald Krentel, Elisabeth Janschek, Caterina Exacoustos, Mario Malzoni, Michael Mueller, Horace Roman, George Condous, Axel Forman, Frank W Jansen, Attila Bokor, Voicu Simedrea, Gernot Hudelist
Advances in preoperative diagnostics as well as in surgical techniques for the treatment of endometriosis, especially for deep endometriosis, call for a classification system, that includes all aspects of the disease such as peritoneal endometriosis, ovarian endometriosis, deep endometriosis, and secondary adhesions. The widely accepted revised American Society for Reproductive Medicine classification (rASRM) has certain limitations because of its incomplete description of deep endometriosis. In contrast, the Enzian classification, which has been implemented in the last decade, has proved to be the most suitable tool for staging deep endometriosis, but does not include peritoneal or ovarian disease or adhesions...
July 2021: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/33232986/transvaginal-sonographic-imaging-and-associated-techniques-for-diagnosis-of-ovarian-deep-endometriosis-and-adenomyosis-a-comprehensive-review
#34
REVIEW
Mee Kristine Aas-Eng, Eliana Montanari, Marit Lieng, Joerg Keckstein, Gernot Hudelist
Imaging of endometriosis and in particular deep endometriosis (DE) is crucial in the clinical management of women facing this debilitating condition. Transvaginal sonography (TVS) is the first-line imaging method and magnetic resonance imaging (MRI) may provide supplemental information. However, the delay in diagnosis of up to 10 years and more is of concern. This problem might be overcome by simple steps using imaging with emphasis on TVS and referral to tertiary care. Finally, TVS is crucial in mapping extent and location of disease in planning surgical therapy and counseling women regarding various therapeutic options...
May 2020: Seminars in Reproductive Medicine
https://read.qxmd.com/read/33126577/sex-specific-expression-of-interleukin-7-8-and-15-in-placentas-of-women-with-gestational-diabetes
#35
JOURNAL ARTICLE
Simon Keckstein, Sophia Pritz, Niklas Amann, Sarah Meister, Susanne Beyer, Magdalena Jegen, Christina Kuhn, Stefan Hutter, Julia Knabl, Sven Mahner, Thomas Kolben, Udo Jeschke, Theresa M Kolben
Gestational diabetes mellitus (GDM) is known to increase the risk for feto-maternal complications during pregnancy. A state of low-grade inflammation, with elevated levels of proinflammatory molecules, similar to patients with obesity or diabetes mellitus type 2 has also been partly described in GDM. The placenta, as unique interface between mother and fetus, is not only passively affected by changes in one of these organisms, but also acts as a modulator by expressing hormones and cytokines. This study aimed to investigate the expression of the proinflammatory cytokines Interleukin (IL) 7, 8 and 15 in GDM in placental tissue...
October 28, 2020: International Journal of Molecular Sciences
https://read.qxmd.com/read/32978068/the-epidemiology-of-endometriosis-is-poorly-known-as-the-pathophysiology-and-diagnosis-are-unclear
#36
REVIEW
Philippe R Koninckx, Anastasia Ussia, Leila Adamyan, Muna Tahlak, Jörg Keckstein, Arnaud Wattiez, Dan C Martin
As the diagnosis requires a laparoscopy, we only have data in women with pain and/or infertility. Endometriosis has been considered to be a single disease defined as 'endometrium like glands and stroma outside the uterus'. However, subtle, typical, cystic ovarian and deep endometriosis lesions should be considered to be different pathologies which occur in all combinations and with different severities. All large datasets, especially those based on hospital discharge records, consider endometriosis to be a single disease without taking into account severity...
September 1, 2020: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://read.qxmd.com/read/32832924/a-european-survey-on-the-conservative-surgical-management-of-endometriotic-cysts-on-behalf-of-the-european-society-for-gynaecological-endoscopy-esge-special-interest-group-sig-on-endometriosis
#37
JOURNAL ARTICLE
G Pados, A Daniilidis, J Keckstein, P Papandreou, S Gordts
The mainstay of endometrioma management, when treatment is required, is surgical. Although laparoscopy is considered to be the gold standard for endometriosis surgery, there is no clarity on the preferred laparoscopic technique, which may depend on whether the primary goalis treatment of infertility or pelvic pain, prevention of recurrence or preservation of ovarian reserve. The aim of this survey to assess the surgical practice of the members of the European Society for Gynaecological Endoscopy (ESGE) on the conservative management of endometiotic cysts in women of reproductive age...
August 5, 2020: Facts, Views & Vision in ObGyn
https://read.qxmd.com/read/32109970/qs-endo-real-a-study-by-the-german-endometriosis-research-foundation-sef-on-the-reality-of-care-for-patients-with-endometriosis-in-germany-austria-and-switzerland
#38
JOURNAL ARTICLE
Felix Zeppernick, Magdalena Zeppernick, Elisabeth Janschek, Monika Wölfler, Sebastian Bornemann, Laura Holtmann, Frank Oehmke, Iris Brandes, Chi Mi Scheible, Darius Salehin, Sigrid Vingerhagen Pethick, Alexander Stephan Boosz, Bernhard Krämer, Martin Sillem, Klaus Bühler, Jörg Keckstein, Karl Werner Schweppe, Ivo Meinhold-Heerlein
Endometriosis affects a significant number of young premenopausal women. Quite apart from the medical challenges, endometriosis is a relevant burden for healthcare and social security systems. Standardized quality indicators for the treatment of endometriosis have not previously been systematically verified. The three-stage study QS ENDO was initiated to record and improve the reality and quality of care. One of its aims is to create quality indicators for the diagnosis and treatment of endometriosis. For the first stage of QS ENDO Real, letters were sent to all 1014 gynecological departments in the German-speaking area of Europe (the DACH region) which included a questionnaire as a means of surveying the current state of care...
February 2020: Geburtshilfe und Frauenheilkunde
https://read.qxmd.com/read/32064361/recommendations-for-the-surgical-treatment-of-endometriosis-part-2-deep-endometriosis
#39
JOURNAL ARTICLE
Joerg Keckstein, Christian M Becker, Michel Canis, Anis Feki, Grigoris F Grimbizis, Lone Hummelshoj, Michelle Nisolle, Horace Roman, Ertan Saridogan, Vasilios Tanos, Carla Tomassetti, Uwe A Ulrich, Nathalie Vermeulen, Rudy Leon De Wilde
STUDY QUESTION: How should surgery for endometriosis be performed? SUMMARY ANSWER: This document provides recommendations covering technical aspects of different methods of surgery for deep endometriosis in women of reproductive age. WHAT IS KNOWN ALREADY: Endometriosis is highly prevalent and often associated with severe symptoms. Yet compared to equally prevalent conditions, it is poorly understood and a challenge to manage. Previously published guidelines have provided recommendations for (surgical) treatment of deep endometriosis, based on the best available evidence, but without technical information and details on how to best perform such treatment in order to be effective and safe...
2020: Human Reproduction Open
https://read.qxmd.com/read/31378689/association-between-disease-extent-and-pain-symptoms-in-patients-with-deep-infiltrating-endometriosis
#40
JOURNAL ARTICLE
Eliana Montanari, Bernhard Dauser, Joerg Keckstein, Elisabeth Kirchner, Zoltan Nemeth, Gernot Hudelist
RESEARCH QUESTION: The study aimed to assess the associations between pre-operative symptoms in patients with deep infiltrating endometriosis (DIE) and intraoperatively determined extent of disease as described by the revised ENZIAN score. DESIGN: This was a retrospective data analysis of women who underwent surgery for DIE between 2014 and 2018 at the Department of Gynecology, Hospital St. John of God, Vienna (a tertiary referral centre for endometriosis). RESULTS: Data from 245 women were analysed...
November 2019: Reproductive Biomedicine Online
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