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https://www.readbyqxmd.com/read/29417332/left-sided-colectomy-one-of-the-important-risk-factors-of-metachronous-colorectal-adenoma-after-colectomy-for-colon-cancer
#1
Gee Young Yun, Hee Seok Moon, In Sun Kwon, Ju Seok Kim, Sun Hyung Kang, Eaum Seok Lee, Seok Hyun Kim, Jae Kyu Sung, Byung Seok Lee, Hyun Yong Jeong
BACKGROUND: Patients with a history of colonic resection for cancer have an increased risk for the development of metachronous malignant lesions. However, there is a lack of data on the detection rates of premalignant lesions during colonoscopy surveillance in these patients, and the few existing studies have shown conflicting results. AIMS: To identify the risk factor of metachronous premalignant lesions after colon cancer surgery. METHODS: We retrospectively screened consecutive patients who had undergone colonic surgery to treat colon cancer at the Chungnam National University Hospital between September 2009 and April 2014...
February 8, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29398398/recurrent-rotator-cuff-tear-is-ultrasound-imaging-reliable
#2
Ron Gilat, Ehud Atoun, Ornit Cohen, Oren Tsvieli, Ehud Rath, Dror Lakstein, Ofer Levy
BACKGROUND AND HYPOTHESIS: The diagnostic workup of the painful shoulder after rotator cuff repair (RCR) can be quite challenging. The aim of this study was to assess the reliability of ultrasonography (US) for the detection of recurrent rotator cuff tears in patients with shoulder pain after RCR. We hypothesized that US for the diagnosis of recurrent rotator cuff tear after RCR would not prove to be reliable when compared with surgical arthroscopic confirmation (gold standard). METHODS: In this cohort study (diagnosis), we retrospectively analyzed the data of 39 patients with shoulder pain after arthroscopic RCR who had subsequently undergone US, followed by revision arthroscopy...
February 2, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29397552/a-new-method-for-a-virtue-based-responsible-conduct-of-research-curriculum-pilot-test-results
#3
Eric Berling, Chet McLeskey, Michael O'Rourke, Robert T Pennock
Drawing on Pennock's theory of scientific virtues, we are developing an alternative curriculum for training scientists in the responsible conduct of research (RCR) that emphasizes internal values rather than externally imposed rules. This approach focuses on the virtuous characteristics of scientists that lead to responsible and exemplary behavior. We have been pilot-testing one element of such a virtue-based approach to RCR training by conducting dialogue sessions, modeled upon the approach developed by Toolbox Dialogue Initiative, that focus on a specific virtue, e...
February 3, 2018: Science and Engineering Ethics
https://www.readbyqxmd.com/read/29379581/erratum-to-infant-with-nasolacrimal-sinonasal-myxoma-diffusion-mri-features-radiology-case-reports-2015-10-article-1104
#4
Teresa Gross Kelly, Sang Hong, Jason Jarzembowski, David Beste
[This corrects the article DOI: 10.2484/rcr.v10i2.1104.].
March 2017: Radiology Case Reports
https://www.readbyqxmd.com/read/29372169/a-comprehensive-evaluation-of-factors-affecting-healing-range-of-motion-strength-and-patient-reported-outcomes-after-arthroscopic-rotator-cuff-repair
#5
James D Wylie, Sean Baran, Erin K Granger, Robert Z Tashjian
Background: Rotator cuff repair (RCR) leads to improved patient outcomes, which may or may not coincide with biological healing of the tendon. Many patient factors may play a role in subjective and objective patient outcomes of surgery. Purpose: To evaluate the effect of various patient factors and tendon healing on range of motion, strength, and functional outcomes after arthroscopic RCR. Study Design: Case-control study; Level of evidence, 3...
January 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29366934/sodium-thiosulfate-mediated-cardioprotection-against-myocardial-ischemia-reperfusion-injury-is-defunct-in-rat-heart-with-co-morbidity-of-vascular-calcification
#6
Sriram Ravindran, Kausthubh Ramachandran, Gino A Kurian
Sodium thiosulfate (STS) has shown promising effects in amelioration of myocardial ischemia-reperfusion injury (IR) in a rat model and is clinically useful in the treatment of chronic kidney disease (CKD) associated calciphylaxis. As the prevalence of cardiac complications is higher in CKD, we tested the effectiveness of STS in a rat model of adenine-induced vascular calcification and subjected the heart to IR. We observed an increased infarct size (29%) by TTC staining, lactate dehydrogenase (54%) and creatine kinase (32%) release in the coronary perfusate and altered hemodynamics compared to a normal rat treated with STS and subjected to IR...
January 20, 2018: Biochimie
https://www.readbyqxmd.com/read/29361423/distal-mononeuropathy-before-and-after-arthroscopic-rotator-cuff-repair-a%C3%A2-prospective%C3%A2-investigation
#7
John G Horneff, Matthew Pepe, Bradford Tucker, Fotios Tjoumakaris, Nicholas Lombardi, Charles Wowkanech, Luke S Austin
PURPOSE: The purpose of this study was to characterize the occurrence of distal mononeuropathy (DMN) in patients before and after arthroscopic rotator cuff repair (RCR) as well as resolution of the symptoms. METHODS: One hundred one patients over the age of 18 undergoing arthroscopic RCR +/- concurrent procedures completed a questionnaire regarding the presence of a symptomatic DMN. Patients with history of diabetic neuropathy, cervical radiculopathy, brachial plexopathy, or Spurling sign were excluded...
January 17, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29361411/unplanned-emergency-department-or-urgent-care-visits-after-outpatient-rotator-cuff-repair-potential-for-avoidance
#8
Ronald A Navarro, Charles C Lin, Abtin Foroohar, Steven R Crain, Michael P Hall
BACKGROUND: With the cost of health care rising, the potential to avoid costs from an unplanned return to the emergency department (ED) or urgent care center (UC) after elective outpatient rotator cuff repair (RCR) has been discussed but not extensively assessed. METHODS: Outpatient RCR procedures were queried in a closed health care system, and all unplanned ED and UC visits within 7 days of procedures were collected and compared with other typical outpatient orthopedic procedures (knee arthroscopy, carpal tunnel release, and anterior cruciate ligament reconstruction)...
January 17, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29334656/activated-protein-c-suppresses-osteoclast-differentiation-via-endothelial-protein-c-receptor-protease-activated-receptor-1-sphingosine-1-phosphate-receptor-and-apolipoprotein-e-receptor-2
#9
Kakunoshin Yoshida, Nobuyuki Akita, Takayuki Okamoto, Kunihiro Asanuma, Atsumasa Uchida, Akihiro Sudo, Motomu Shimaoka, Koji Suzuki, Tatsuya Hayashi
INTRODUCTION: Bone remodeling relies on a delicate balance between formation and resorption of bone tissues, processes in which bone-forming osteoblasts and bone-resorbing osteoclasts play central roles. Recently, we reported that anticoagulant activated protein C (APC) promotes osteoblast proliferation, but the role of the blood coagulation system in bone remodeling remains unclear. In this study, to further elucidate the relationship between bone remodeling and blood coagulation, we investigated the effect of APC on osteoclast differentiation...
January 3, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29330607/river-continuity-restoration-and-diadromous-fishes-much-more-than-an-ecological-issue
#10
H Drouineau, C Carter, M Rambonilaza, G Beaufaron, G Bouleau, A Gassiat, P Lambert, S le Floch, S Tétard, E de Oliveira
Ecosystem fragmentation is a serious threat to biodiversity and one of the main challenges in ecosystem restoration. River continuity restoration (RCR) has often targeted diadromous fishes, a group of species supporting strong cultural and economic values and especially sensitive to river fragmentation. Yet it has frequently produced mixed results and diadromous fishes remain at very low levels of abundance. Against this background, this paper presents the main challenges for defining, evaluating and achieving effective RCR...
January 12, 2018: Environmental Management
https://www.readbyqxmd.com/read/29301726/evaluation-of-the-relative-citation-ratio-a%C3%A2-new%C3%A2-national-institutes-of-health-supported-bibliometric-measure-of-research-productivity-among-academic-radiation-oncologists
#11
Calvin B Rock, Arpan V Prabhu, C David Fuller, Charles R Thomas, Emma B Holliday
PURPOSE: Publication metrics are useful in evaluating academic faculty for awarding grants, recruitment, and promotion. A new metric, the relative citation ratio (RCR), was recently released by the National Institutes of Health (NIH); however, no benchmark data yet exist. We sought to create benchmark data for physician faculty in academic radiation oncology (RO) and analyze correlations associated with increased academic productivity. METHODS: Citation database searches were performed for all US radiation oncologists affiliated with academic RO programs...
January 2, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29300329/reliability-aware-cooperative-node-sleeping-and-clustering-in-duty-cycled-sensors-networks
#12
Jeungeun Song, Yiming Miao, Enmin Song, M Shamim Hossain, Mohammed F Alhamid
Duty-cycled sensor networks provide a new perspective for improvement of energy efficiency and reliability assurance of multi-hop cooperative sensor networks. In this paper, we consider the energy-efficient cooperative node sleeping and clustering problems in cooperative sensor networks where clusters of relay nodes jointly transmit sensory data to the next hop. Our key idea for guaranteeing reliability is to exploit the on-demand number of cooperative nodes, facilitating the prediction of personalized end-to-end (ETE) reliability...
January 4, 2018: Sensors
https://www.readbyqxmd.com/read/29259530/%C3%A2-an-appreciation-of-the-gene-an-intimate-history-by-siddhartha-mukherjee-and-a-call-for-expanded-training-in-the-responsible-conduct-of-research%C3%A2
#13
REVIEW
Evan D Morris
The Gene: An Intimate History by Siddhartha Mukherjee, first published in 2016, is a comprehensive and fascinating recounting of the discovery of the gene and genetics research from wrinkled peas to CRISPR/Cas9 and all the details in between. In Mukherjee's sweeping history, the science is clearly depicted but also tightly integrated into the political movements and world events that it spawned, both hopeful and detestable. Two stories from The Gene are the central focuses of this article. One story is driven by the desire of Eugenicists in early 20th century America to rid the population of defective traits...
December 2017: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/29250047/the-different-faces-of-rolling-circle-replication-and-its-multifunctional-initiator-proteins
#14
REVIEW
Paweł Wawrzyniak, Grażyna Płucienniczak, Dariusz Bartosik
Horizontal gene transfer (HGT) contributes greatly to the plasticity and evolution of prokaryotic and eukaryotic genomes. The main carriers of foreign DNA in HGT are mobile genetic elements (MGEs) that have extremely diverse genetic structures and properties. Various strategies are used for the maintenance and spread of MGEs, including (i) vegetative replication, (ii) transposition (and other types of recombination), and (iii) conjugal transfer. In many MGEs, all of these processes are dependent on rolling-circle replication (RCR)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29204295/associations-of-mitochondrial-fatty-acid-oxidation-with-body-fat-in-premenopausal-women
#15
Jonathan L Warren, Barbara A Gower, Gary R Hunter, Samuel T Windham, Douglas R Moellering, Gordon Fisher
Higher in vivo fatty acid (FA) oxidation rates have been reported in obese individuals compared to lean counterparts; however whether this reflects a shift in substrate-specific oxidative capacity at the level of the skeletal muscle mitochondria has not been examined. The purpose of this study was to test the hypothesis that in situ measures of skeletal muscle mitochondria FA oxidation would be positively associated with total body fat. Participants were 38 premenopausal women (BMI = 26.5 ± 4.3 kg/m2). Total and regional fat were assessed by dual-energy X-ray absorptiometry (DXA)...
2017: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/29203150/retroviral-and-lentiviral-safety-analysis-of-gene-modified-t-cell-products-and-infused-hiv-and-oncology-patients
#16
Katherine T Marcucci, Julie K Jadlowsky, Wei-Ting Hwang, Megan Suhoski-Davis, Vanessa E Gonzalez, Irina Kulikovskaya, Minnal Gupta, Simon F Lacey, Gabriela Plesa, Anne Chew, J Joseph Melenhorst, Bruce L Levine, Carl H June
Replication-competent retrovirus/lentivirus (RCR/L) and insertional oncogenesis are potential safety risks with integrating viruses in gene-modified cell therapies. As such, the Food and Drug Administration guidances outline RCR/L-monitoring methods throughout the entire gene therapy treatment cycle. We present data for 17 vector lots, 375 manufactured T cell products, and 308 patients post-infusion across both HIV and oncology indications, showing no evidence of RCR/L. Given our data, a Poisson probability model estimates that a single patient, or a group of patients, would need to be followed for at least 52...
October 20, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29185162/the-effect-of-medicaid-payer-status-on-patient-outcomes-following-repair-of-massive-rotator-cuff-tears
#17
V Sabesan, J Whaley, G Petersen-Fitts, A Sherwood, M Sweet, D J L Lima, D Malone
BACKGROUND: The influence of socioeconomic status and insurance type has not been studied extensively for RCR, particularly not in the high risk massive RCT population. The purpose of this study is to identify relationships between Medicaid payer status and patient outcomes following massive RCR. METHODS: A retrospective review of shoulder surgery database identified 29 patients undergoing massive rotator cuff repair. Patients were stratified based on insurance type into two cohorts, Medicaid (14 patients) and non-Medicaid (15 patients)...
November 28, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/29176953/mitochondrial-proton-leak-compensates-for-reduced-oxidative-power-during-frequent-hypothermic-events-in-a-protoendothermic-mammal-echinops-telfairi
#18
Elias T Polymeropoulos, R Oelkrug, M Jastroch
The lesser hedgehog tenrec (Echinops telfairi) displays reptile-like thermoregulatory behavior with markedly high variability in body temperature and metabolic rate. To understand how energy metabolism copes with this flexibility, we studied the bioenergetics of isolated liver mitochondria from cold (20°C) and warm (27°C) acclimated tenrecs. Different acclimation temperatures had no impact on mitochondrial respiration using succinate as the substrate. Mimicking the variation of body temperature by changing assay temperatures from 22 to 32°C highlighted temperature-sensitivity of respiration...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29166711/-effects-of-caspase-1-inhibitor-vx765-on-cold-restraint-stress-induced-acute-gastric-ulcer-in-mice
#19
S Q Zheng, X D Hong, T S Chen, P F Luo, S C Xiao
Objective: To investigate the protective effects of caspase-1 inhibitor VX765 on gastric mucosa of mice with cold-restraint stress-induced acute gastric ulcer. Methods: Twenty-four specific pathogen free male C57BL/6J mice were divided into normal control group (NC), cold restrain group (CR), VX765 pre-treatment+ cold restrain group (VCR), and rabeprazole pre-treatment+ cold restrain group (RCR) according to the random number table, with 6 mice in each group. Mice in group NC were injected intraperitoneally with solution of 10 mL/kg dimethylsulfoxide (DMSO) and phosphate buffer solution (PBS)...
November 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29146036/long-term-outcomes-after-infected-mini-open-rotator-cuff-repair-results-of-a-10-year-review
#20
REVIEW
Rafik Asaid, Kevin Eng, Graeme Brown, Richard Page
BACKGROUND: Infection after rotator cuff repair (RCR) is uncommon. There are few reports in the literature regarding the management and long-term results of patients in whom deep infection of the shoulder develops after RCR. The objective of this study was to assess the long-term clinical and radiologic outcomes of these patients. METHODS: We retrospectively reviewed a consecutive series of 764 patients after mini-open RCR in which 9 patients had postoperative infection...
November 13, 2017: Journal of Shoulder and Elbow Surgery
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