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https://www.readbyqxmd.com/read/29204295/associations-of-mitochondrial-fatty-acid-oxidation-with-body-fat-in-premenopausal-women
#1
Jonathan L Warren, Barbara A Gower, Gary R Hunter, Samuel T Windham, Douglas R Moellering, Gordon Fisher
Higher in vivo fatty acid (FA) oxidation rates have been reported in obese individuals compared to lean counterparts; however whether this reflects a shift in substrate-specific oxidative capacity at the level of the skeletal muscle mitochondria has not been examined. The purpose of this study was to test the hypothesis that in situ measures of skeletal muscle mitochondria FA oxidation would be positively associated with total body fat. Participants were 38 premenopausal women (BMI = 26.5 ± 4.3 kg/m2). Total and regional fat were assessed by dual-energy X-ray absorptiometry (DXA)...
2017: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/29203150/retroviral-and-lentiviral-safety-analysis-of-gene-modified-t-cell-products-and-infused-hiv-and-oncology-patients
#2
Katherine T Marcucci, Julie K Jadlowsky, Wei-Ting Hwang, Megan Suhoski-Davis, Vanessa E Gonzalez, Irina Kulikovskaya, Minnal Gupta, Simon F Lacey, Gabriela Plesa, Anne Chew, J Joseph Melenhorst, Bruce L Levine, Carl H June
Replication-competent retrovirus/lentivirus (RCR/L) and insertional oncogenesis are potential safety risks with integrating viruses in gene-modified cell therapies. As such, the Food and Drug Administration guidances outline RCR/L-monitoring methods throughout the entire gene therapy treatment cycle. We present data for 17 vector lots, 375 manufactured T cell products, and 308 patients post-infusion across both HIV and oncology indications, showing no evidence of RCR/L. Given our data, a Poisson probability model estimates that a single patient, or a group of patients, would need to be followed for at least 52...
October 20, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29185162/the-effect-of-medicaid-payer-status-on-patient-outcomes-following-repair-of-massive-rotator-cuff-tears
#3
V Sabesan, J Whaley, G Petersen-Fitts, A Sherwood, M Sweet, D J L Lima, D Malone
BACKGROUND: The influence of socioeconomic status and insurance type has not been studied extensively for RCR, particularly not in the high risk massive RCT population. The purpose of this study is to identify relationships between Medicaid payer status and patient outcomes following massive RCR. METHODS: A retrospective review of shoulder surgery database identified 29 patients undergoing massive rotator cuff repair. Patients were stratified based on insurance type into two cohorts, Medicaid (14 patients) and non-Medicaid (15 patients)...
November 28, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/29176953/mitochondrial-proton-leak-compensates-for-reduced-oxidative-power-during-frequent-hypothermic-events-in-a-protoendothermic-mammal-echinops-telfairi
#4
Elias T Polymeropoulos, R Oelkrug, M Jastroch
The lesser hedgehog tenrec (Echinops telfairi) displays reptile-like thermoregulatory behavior with markedly high variability in body temperature and metabolic rate. To understand how energy metabolism copes with this flexibility, we studied the bioenergetics of isolated liver mitochondria from cold (20°C) and warm (27°C) acclimated tenrecs. Different acclimation temperatures had no impact on mitochondrial respiration using succinate as the substrate. Mimicking the variation of body temperature by changing assay temperatures from 22 to 32°C highlighted temperature-sensitivity of respiration...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29166711/-effects-of-caspase-1-inhibitor-vx765-on-cold-restraint-stress-induced-acute-gastric-ulcer-in-mice
#5
S Q Zheng, X D Hong, T S Chen, P F Luo, S C Xiao
Objective: To investigate the protective effects of caspase-1 inhibitor VX765 on gastric mucosa of mice with cold-restraint stress-induced acute gastric ulcer. Methods: Twenty-four specific pathogen free male C57BL/6J mice were divided into normal control group (NC), cold restrain group (CR), VX765 pre-treatment+ cold restrain group (VCR), and rabeprazole pre-treatment+ cold restrain group (RCR) according to the random number table, with 6 mice in each group. Mice in group NC were injected intraperitoneally with solution of 10 mL/kg dimethylsulfoxide (DMSO) and phosphate buffer solution (PBS)...
November 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29146036/long-term-outcomes-after-infected-mini-open-rotator-cuff-repair-results-of-a-10-year-review
#6
REVIEW
Rafik Asaid, Kevin Eng, Graeme Brown, Richard Page
BACKGROUND: Infection after rotator cuff repair (RCR) is uncommon. There are few reports in the literature regarding the management and long-term results of patients in whom deep infection of the shoulder develops after RCR. The objective of this study was to assess the long-term clinical and radiologic outcomes of these patients. METHODS: We retrospectively reviewed a consecutive series of 764 patients after mini-open RCR in which 9 patients had postoperative infection...
November 13, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29138850/role-of-mitochondrial-function-in-the-invasiveness-of-human-colon-cancer-cells
#7
Chen-Sung Lin, Li-Tzu Liu, Liang-Hung Ou, Siao-Cian Pan, Chia-I Lin, Yau-Huei Wei
We investigated the role of mitochondrial function in the invasiveness of human colorectal cancer (CRC) cell lines, using paired primary SW480 and metastatic SW620 cells, and appraised the clinical relevance of the alteration of mtDNA copy number in 33 pairs of CRC specimens after surgical resection. Suppression of mitochondrial function was achieved by the exposure of cells to oligomycin A (OA) or by knockdown of mitochondrial transcriptional factor A (TFAM) to evaluate their effects on energy metabolism, reactive oxygen species, protein expression levels of epithelial-mesenchymal transition (EMT) markers and invasive activity of CRC cells...
November 9, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29133645/retinal-shortening-ultrasonic-evaluation-of-proliferative-vitreoretinopathy
#8
Brijesh Takkar, Shreyas Temkar, Nripen Gaur, Pradeep Venkatesh, Rohan Chawla, Atul Kumar
PURPOSE: To evaluate the effect of extraretinal proliferative vitreoretinopathy (PVR) on retinal shortening in eyes with rhegmatogenous retinal detachment (RD) using ultrasound (USG) and objectively prove the presence of intraretinal PVR (iPVR). METHODS: This is a double-masked pilot prospective controlled case series. Patients with total RD planned for vitreoretinal surgery were included in the study. USG was used to determine retinal-to-choroidal length ratios (RCRs) in all the quadrants...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29125330/benign-and-malignant-enlarged-chest-nodes-staging-by-diffusion-weighted-mri-an-alternative-to-mediastinoscopy
#9
Monica Sigovan, Pia Akl, Caroline Mesmann, Francois Tronc, Salim Si Mohamed, Philippe Douek, Loic Boussel
OBJECTIVE: To evaluate the accuracy of diffusion weighted MRI with background suppression (DWIBS) in differentiating between malignant and benign mediastinal lymph-nodes. METHODS: Consecutive patients with enlarged mediastinal lymph-nodes underwent MRI DWIBS within 10 days prior to mediastinoscopy. Relative contrast ratios (RCR) were computed on b800 and apparent diffusion coefficient (ADC) maps by dividing the node signal with the chest muscle signal, using manually drawn regions of interest (ROIs) by radiologists, blinded to pathology...
November 10, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29100767/arthroscopic-correction-of-the-critical-shoulder-angle-through-lateral-acromioplasty-a-safe-adjunct-to-rotator-cuff-repair
#10
Christian Gerber, Sabrina Catanzaro, Michael Betz, Lukas Ernstbrunner
PURPOSE: To investigate whether arthroscopic lateral acromioplasty reliably decreases the critical shoulder angle (CSA) and whether it is associated with damage to the deltoid or other complications. METHODS: Patients undergoing arthroscopic rotator cuff repair (RCR) with lateral but without anterior acromioplasty for degenerative, full-thickness rotator cuff tears and a CSA of 34° or greater were retrospectively reviewed. Patients with traumatic or irreparable rotator cuff tears, osteoarthritis, or previous surgery were excluded...
October 31, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29099894/effects-of-platelet-rich-plasma-and-indomethacin-on-biomechanics-of-rotator-cuff-repair
#11
Molly C Meadows, David M Levy, Christopher M Ferry, Thomas R Gardner, Takeshi Teratani, Christopher S Ahmad
We conducted a study to determine if platelet-rich plasma (PRP) enhances the strength of rotator cuff repair (RCR) and if concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) affects PRP efficacy. We also wanted to determine the optimal centrifugation protocol for making PRP from rats. This study used 48 rats, 14 in a centrifugation protocol and 34 in an operative protocol. Six syngeneic rats from the operative group were used as PRP blood donors; the other 28 operative rats underwent bilateral RCRs...
September 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/29089142/survival-in-patients-with-parotid-gland-carcinoma-results-of-a-multi-center-study
#12
Keigo Honda, Shinzo Tanaka, Shogo Shinohara, Ryo Asato, Hisanobu Tamaki, Toshiki Maetani, Ichiro Tateya, Morimasa Kitamura, Shinji Takebayashi, Kazuyuki Ichimaru, Yoshiharu Kitani, Yohei Kumabe, Tsuyoshi Kojima, Koji Ushiro, Masanobu Mizuta, Koichiro Yamada, Koichi Omori
BACKGROUND: Parotid gland carcinoma is a rare malignancy, comprising only 1-4% of head and neck carcinomas; therefore, it is difficult for a single institution to perform meaningful analysis on its clinical characteristics. The aim of this study was to update the clinical knowledge of this rare disease by a multi-center approach. METHODS: The study was conducted by the Kyoto University Hospital and Affiliated Facilities Head and Neck Clinical Oncology Group (Kyoto-HNOG)...
October 24, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29069582/assessment-of-the-potential-human-health-risks-from-exposure-to-complex-substances-in-accordance-with-reach-requirements-white-spirit-as-a-case-study
#13
Richard H McKee, Rosalie Tibaldi, Moyinoluwa D Adenuga, Juan-Carlos Carrillo, Alison Margary
The European chemical control regulation (REACH) requires that data on physical/chemical, toxicological and environmental hazards be compiled. Additionally, REACH requires formal assessments to ensure that substances can be safely used for their intended purposes. For health hazard assessments, reference values (Derived No Effect levels, DNELs) are calculated from toxicology data and compared to estimated exposure levels. If the ratio of the predicted exposure level to the DNEL, i.e. the Risk Characterization Ratio (RCR), is less than 1, the risk is considered controlled; otherwise, additional Risk Management Measures (RMM) must be applied...
October 22, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29051900/previous-rotator-cuff-repair-is-associated-with-inferior-clinical-outcomes-after-reverse-total-shoulder-arthroplasty
#14
Edward J W Shields, Denise M Koueiter, Tristan Maerz, Adam Schwark, J Michael Wiater
BACKGROUND: Although recent evidence suggests that any prior shoulder surgery may cause inferior shoulder arthroplasty outcomes, there is no consensus on whether previous rotator cuff repair (RCR) is associated with inferior outcomes after reverse total shoulder arthroplasty (RTSA). PURPOSE: To retrospectively compare outcomes in patients who underwent RTSA with and without previous RCR. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: Patients with prior RCR and those without previous shoulder surgery (control) who underwent RTSA for cuff tear arthropathy or irreparable cuff tear were retrospectively identified from a prospective database...
October 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29036468/exponential-propagation-of-large-circular-dna-by-reconstitution-of-a-chromosome-replication-cycle
#15
Masayuki Su'etsugu, Hiraku Takada, Tsutomu Katayama, Hiroko Tsujimoto
Propagation of genetic information is a fundamental property of living organisms. Escherichia coli has a 4.6 Mb circular chromosome with a replication origin, oriC. While the oriC replication has been reconstituted in vitro more than 30 years ago, continuous repetition of the replication cycle has not yet been achieved. Here, we reconstituted the entire replication cycle with 14 purified enzymes (25 polypeptides) that catalyze initiation at oriC, bidirectional fork progression, Okazaki-fragment maturation and decatenation of the replicated circular products...
November 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29027428/-gene-cloning-and-expression-analysis-of-benzoic-acid-stress-responsive-transcription-factor-wrky7-in-panax-ginseng
#16
Zi Wang, Yong Li, Rong Wang, Wan-Long Ding
WRKY transcription factor is one of the most important transcription factor families widely existing in higher plants, which playing critical role in plant morphogenesis, development, biotic (including phytopathogens, pests etc.) and abiotic (drought, salt, chilling, high temperature, etc.) stress. In the present work, primers used to amplify full-length gene encoding WRKY transcription factor were designed based on the transcriptome data of P. ginseng that induced by benzoic acid, one of the most important autotoxins identified from root exudates and rhizosphere soil of P...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28977784/exogenous-h2s-protects-against-diabetic-cardiomyopathy-by-activating-autophagy-via-the-ampk-mtor-pathway
#17
Fan Yang, Linxue Zhang, Zhaopeng Gao, Xiaojiao Sun, Miao Yu, Shiyun Dong, Jichao Wu, Yajun Zhao, Changqing Xu, Weihua Zhang, Fanghao Lu
BACKGROUND/AIM: Autophagy plays an important role in cellular homeostasis through the disposal and recycling of cellular components. Hydrogen sulphide (H2S) is the third endogenous gas that has been shown to confer cardiac protective effects. Given the regulation of autophagy in cardioprotection, this study aimed to investigate the protective effects of H2S via autophagy during high glucose treatment. METHODS: This study investigated the content of H2S in the plasma as well as myocardial, ultrastructural changes in mitochondria and autophagosomes...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28974588/thoracic-ultrasound-experiences-among-respiratory-specialty-trainees-in-the-uk
#18
Parthipan Sivakumar, Meera Kamalanathan, Anne S Collett, Liju Ahmed
Achieving competence in thoracic ultrasound is a mandatory requirement for the successful completion of respiratory specialty training in the UK. We evaluated trainee competencies, access to training and confidence in thoracic ultrasound by means of a nationally distributed survey with the participation of 202 (of approximately 600) respiratory trainees. 65.8% (131/199) of responders are RCR Level 1 accredited and 20.6% (22/107) of these trainees had performed fewer than 20 ultrasounds in the past year. 29...
October 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28968388/a-critical-evaluation-of-the-algorithm-behind-the-relative-citation-ratio-rcr
#19
A Cecile J W Janssens, Michael Goodman, Kimberly R Powell, Marta Gwinn
No abstract text is available yet for this article.
October 2017: PLoS Biology
https://www.readbyqxmd.com/read/28968381/additional-support-for-rcr-a-validated-article-level-measure-of-scientific-influence
#20
B Ian Hutchins, Travis A Hoppe, Rebecca A Meseroll, James M Anderson, George M Santangelo
No abstract text is available yet for this article.
October 2017: PLoS Biology
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