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https://www.readbyqxmd.com/read/29669489/validity-and-responsiveness-of-the-short-version-of-western-ontario-rotator-cuff-index-short-worc-in-patients-with-rotator-cuff-repair
#1
Neha Dewan, Joy C MacDermid, Norma MacIntyre
Study Design Clinical measurement. Background Recently, the Western Ontario Rotator Cuff Index (WORC) has been shortened; but few studies report measurement properties. Objective To compare the validity and responsiveness of disease-specific measures, short version of the Western Ontario Rotator Cuff Index (Short-WORC) and WORC with comparator measures (joint-specific: Shoulder Pain and Disability Index; SPADI, Simple Shoulder Test; SST); region-specific (Disabilities of the Arm, Shoulder and Hand; DASH); general health status (12-item short form health survey; SF-12v2)) in the patients undergoing rotator cuff repair (RCR)...
April 18, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29657471/arthroscopic-knotless-rotator-cuff-repair-factors-associated-with-construct-selection-and-recent-trends-from-a-manual-review-of-1617-cases
#2
Sarav S Shah, Aalok Shah, Vivek Chadayammuri, Marlena McGill, Nicole Wei, David V Tuckman, Nicholas A Sgaglione
Purpose: Our aim was to identify predictors of construct selection and recent trends for arthroscopic knotless rotator cuff repair (RCR). Methods: A manual review of 1617 operative reports was performed. Results: A medium-sized tear had a threefold increase in odds of single row (SR) knotless repair (OR, 6.91; p = 0.009) versus SR knotted (OR, 3.05; p = 0.003). Generalist orthopaedic surgeons were 79% less likely to perform SR knotless repairs versus sports medicine trained specialists (p < 0...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29643511/activity-based-e3-ligase-profiling-uncovers-an-e3-ligase-with-esterification-activity
#3
Kuan-Chuan Pao, Nicola T Wood, Axel Knebel, Karim Rafie, Mathew Stanley, Peter D Mabbitt, Ramasubramanian Sundaramoorthy, Kay Hofmann, Daan M F van Aalten, Satpal Virdee
Ubiquitination is initiated by transfer of ubiquitin (Ub) from a ubiquitin-activating enzyme (E1) to a ubiquitin-conjugating enzyme (E2), producing a covalently linked intermediate (E2-Ub) 1 . Ubiquitin ligases (E3s) of the 'really interesting new gene' (RING) class recruit E2-Ub via their RING domain and then mediate direct transfer of ubiquitin to substrates 2 . By contrast, 'homologous to E6-AP carboxy terminus' (HECT) E3 ligases undergo a catalytic cysteine-dependent transthiolation reaction with E2-Ub, forming a covalent E3-Ub intermediate3,4 ...
April 11, 2018: Nature
https://www.readbyqxmd.com/read/29620913/into-tunnel-repair-versus-onto-surface-repair-for-rotator-cuff-tears-in-a-rabbit-model
#4
Xiaoxi Li, Peng Shen, Wei Su, Song Zhao, Jinzhong Zhao
BACKGROUND: Clinically, onto-surface repair is commonly used for rotator cuff tears. The retear rate after rotator cuff repair (RCR) is relatively high, with failure occurring mostly at the tendon-bone connection site. For anterior cruciate ligament (ACL) reconstruction, into-tunnel reconstruction is commonly employed. The retear rate after ACL reconstruction is relatively low, with retears seldom occurring at the tendon-bone interface. No study on into-tunnel RCR has been conducted. HYPOTHESIS: Into-tunnel RCR could promote fibrocartilage regeneration at the tendon-bone interface and has biomechanical advantage over onto-surface repair in a rabbit rotator cuff tear model...
April 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29607991/-promoting-research-integrity
#5
Hiromichi Suzuki
 Japan Agency for Medical Research and Development (AMED) was launched in April 2015 to promote integrated medical research and development (R&D) ranging from basic research to practical applications, in order to smoothly achieve the nationwide application of research outcomes, and to establish an environment therefor. AMED consolidates budgets for R&D expenses, which had previously been allocated from different sources, such as the Ministry of Education, Culture, Sports, Science and Technology, the Ministry of Health, Labour and Welfare, and the Ministry of Economy, Trade and Industry...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29582254/2-4-dinitrophenol-attenuates-mitochondrial-dysfunction-and-improves-neurobehavioral-outcomes-postanoxia-in-neonatal-rats
#6
Puneet K Samaiya, Gopeshwar Narayan, Ashok Kumar, Sairam Krishnamurthy
Following anoxia, a rapid and marked mitochondrial-linked cell death occurs in the cerebral cortex of newborn rats which leads to insult advancement within a couple of days and causes lifelong neurobehavioral abnormalities. The present study investigated the role of 2,4 dinitrophenol (2,4 DNP) in three doses, i.e.,1, 2.5, and 5 mg/kg on anoxia-induced time-dependent mitochondrial dysfunction and associated neurobehavioral outcome using a well-established global model of anoxia. Briefly, rat pups of 30-h age (P2) were subjected to two episodes of anoxia (10 min each) at 24 h of the time interval in an enclosed chamber supplied with 100% N2 and immersed in a water bath (35-37 °C) to avoid hypothermia...
March 26, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29574125/higher-incidence-of-metachronous-advanced-neoplasia-in-patients-with-synchronous-advanced-neoplasia-and-left-sided-colorectal-resection-for-colorectal-cancer
#7
Yohei Yabuuchi, Kenichiro Imai, Kinichi Hotta, Sayo Ito, Yoshihiro Kishida, Tomohiro Yamaguchi, Akio Shiomi, Yusuke Kinugasa, Masao Yoshida, Masaki Tanaka, Noboru Kawata, Naomi Kakushima, Kohei Takizawa, Hirotoshi Ishiwatari, Hiroyuki Matsubayashi, Hiroyuki Ono
BACKGROUND AND AIMS: There is an increased risk of developing metachronous colorectal cancer (CRC) in the remnant colorectum after surgical resection of CRC. We evaluated the incidence of metachronous advanced neoplasia (AN) after surgery for CRC according to resection type and synchronous AN. METHODS: This cohort study included patients who underwent surgical resection for initial CRC at a tertiary cancer center in Japan between September 2002 and December 2012...
March 21, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29567270/pretreatment-mri-features-associated-with-diagnostic-accuracy-of-post-treatment-mri-after-neoadjuvant-chemotherapy
#8
N L Eun, H M Gweon, E J Son, J H Youk, J-A Kim
AIM: To investigate whether pretreatment magnetic resonance imaging (MRI) features are associated with diagnostic accuracy of post-treatment MRI for predicting pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) in patients with breast cancer. MATERIALS AND METHODS: From January 2005 and December 2016, 221 consecutive patients (mean age, 50 years; range, 20-81 years) who had undergone NAC, breast MRI before and after NAC, and surgery for invasive breast cancer were enrolled...
March 19, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29554905/cytotoxic-activity-of-the-twigs-of-cinnamomum-cassia-through-the-suppression-of-cell-proliferation-and-the-induction-of-apoptosis-in-human-colorectal-cancer-cells
#9
Gwang Hun Park, Hun Min Song, Su Bin Park, Ho-Jun Son, Yurry Um, Hyun-Seok Kim, Jin Boo Jeong
BACKGROUND: Because twigs of Cinnamomum cassia (TC) have been reported to exert anti-cancer activity, the mechanistic study for TC's anti-cancer activity is required. Thus, we elucidated the potential molecular mechanism of TC's anti-proliferative effect and the induction of apoptosis in human colorectal cancer cells. METHODS: How water extracts form TC (TC-HW) was used in this study. Anti-cell proliferative effect of TC-HW was evaluated by MTT assay. The change of protein or mRNA level by TC-HW was evaluated by Western blot and RT-RCR, respectively...
January 25, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29531675/macroinvertebrate-identity-mediates-the-effects-of-litter-quality-and-microbial-conditioning-on-leaf-litter-recycling-in-temperate-streams
#10
Mathieu Santonja, Laura Pellan, Christophe Piscart
Plant litter decomposition is an essential ecosystem function that contributes to carbon and nutrient cycling in streams. Aquatic shredders, mainly macroinvertebrates, can affect this process in various ways; they consume leaf litter, breaking it down into fragments and creating suitable habitats or resources for other organisms through the production of fine particulate organic matter (FPOM). However, measures of litter-feeding traits across a wide range of aquatic macroinvertebrates are still rare. Here, we assessed the contributions of 11 species of freshwater macroinvertebrates to litter decomposition, by measuring consumption rate, FPOM production, and assimilation rate of highly decomposable ( Alnus glutinosa ) or poorly decomposable ( Quercus robur ) leaf litter types...
March 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29516422/effect-of-natural-gas-flaring-upon-the-butterfly-eurema-hecabe-lepidoptera-pieridae-and-its-host-plant-cassia-tora-fabales-fabaceae-in-two-group-gathering-stations-of-assam-india-an-approach-of-environmental-monitoring
#11
Bitopan Sarma, Pranab Ram Bhattacharyya, Mantu Bhuyan
Apart from other pollutants, flaring of natural gas adds carbon dioxide into the environment and changes the atmospheric composition, including temperature and humidity. As a major gaseous product, carbon dioxide changes plant structural components as well as herbivores, i.e., insect by dilution of nitrogen under such circumstances. Present analysis demonstrated the impact of gas flaring upon adjoining biota especially Eurema hecabe butterfly and its host plant, Cassia tora in some wells (group gathering stations) of Assam, India...
March 7, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29507654/nocturnal-hypoxia-improves-glucose-disposal-decreases-mitochondrial-efficiency-and-increases-reactive-oxygen-species-in-the-muscle-and-liver-of-c57bl-6j-mice-independent-of-weight-change
#12
Simona Ioja, Srikanth Singamsetty, Catherine Corey, Lanping Guo, Faraaz Shah, Michael J Jurczak, Bryan J McVerry, Sruti Shiva, Christopher P O'Donnell
Although acute exposure to hypoxia can disrupt metabolism, longer-term exposure may normalize glucose homeostasis or even improve glucose disposal in the presence of obesity. We examined the effects of two-week exposure to room air (Air), continuous 10% oxygen (C10%), and 12 hr nocturnal periods of 10% oxygen (N10%) on glucose disposal, insulin responsiveness, and mitochondrial function in lean and obese C57BL/6J mice. Both C10% and N10% improved glucose disposal relative to Air in lean and obese mice without evidence of an increase in insulin responsiveness; however, only the metabolic improvements with N10% exposure occurred in the absence of confounding effects of weight loss...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29494745/functional-outcomes-and-predictors-of-failure-after-rotator-cuff-repair-during-total-shoulder-arthroplasty
#13
Michael Livesey, John G Horneff, Daniel Sholder, Mark Lazarus, Gerald Williams, Surena Namdari
A well-functioning rotator cuff is necessary for successful anatomic total shoulder arthroplasty (TSA). This study evaluated patients who underwent concomitant TSA and rotator cuff repair (RCR) for functional outcomes, revision rates, and predictors of poor results. Retrospective chart review was conducted to identify patients who underwent TSA and RCR. Demographic data, rotator cuff tear and RCR characteristics, range of motion, and radiographs were recorded. Minimum 2-year functional outcomes were obtained...
March 1, 2018: Orthopedics
https://www.readbyqxmd.com/read/29492511/-macrophages-depletion-impairs-skeletal-muscle-regeneration-by-regulating-inflammation-and-oxidative-stress-levels
#14
Xiao-Guang Liu, Pei-Jie Chen, Lin-Lin Zhao, Zhi-Gang Zeng, Wei-Hua Xiao
The objective of this study was to explore the roles of macrophages in the regeneration of injured skeletal muscle and the mechanisms involved. Mice were randomly divided into the following groups: muscle contusion (S), muscle contusion control (SCon ), macrophages depleted (T) and macrophages depleted control (TCon ) groups. Muscle contusion model was created by high-energy blunt injury. Macrophages depletion model was constructed by injection of clodronate-liposomes. Their gastrocnemius muscles were harvested at the time points of 1, 3, 7 and 14 d post-injury...
February 25, 2018: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/29491207/method-for-prediction-of-efficacy-of-sugammadex-administered-to-recover-from-rocuronium-induced-neuromuscular-blockade-in-gynecological-laparoscopic-surgery-cases
#15
Koji Kimura, Kazuya Omura, Tetsuya Hoshino, Hiroyuki Takahashi, Masaharu Imaura, Yasuhiko Yamada
Sugammadex (SDX), a neuromuscular blocking-reversal agent, quickly reverses neuromuscular blockade induced by rocuronium (RCR). SDX dosage is set according to the state of neuromuscular blockade determined with a neuromuscular monitoring device. However, in clinical situations, such a devise is not frequently used. Here, we report construction of a method for theoretically setting SDX dose by which the optimum reverse time (RT) can be obtained for individual patients even when the device is not available. The subjects were 42 adult female patients who underwent laparoscopic surgery from 1 August 2015 to 31 March 2016, during which RCR and SDX were administered...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29477764/effects-of-cd-accumulation-on-cutworm-spodoptera-litura-larvae-via-cd-treated-chinese-flowering-cabbage-brassica-campestris-and-artificial-diets
#16
Keqing Li, Jin Chen, Pan Jin, Junfei Li, Jianwu Wang, Yinghua Shu
By exposing herbivorous cutworm Spodoptera litura (Lepidoptera: Noctuidae) larvae to Cadmium (Cd) stress via Cd treated cabbages Brassica campestris and artificial diets, we investigated effects of Cd accumulation in larvae on their survival and food utilization. The results showed that Cd transferred from soils contaminated with different Cd concentrations through cabbages-larvae, and be mainly accumulated in larvae guts. There was a dose-response relationship between Cd accumulations in larvae cuticle, head, guts and Cd concentrations in artificial diets, and the highest one was found in the guts, regardless of generations...
February 8, 2018: Chemosphere
https://www.readbyqxmd.com/read/29417332/left-sided-colectomy-one-of-the-important-risk-factors-of-metachronous-colorectal-adenoma-after-colectomy-for-colon-cancer
#17
Gee Young Yun, Hee Seok Moon, In Sun Kwon, Ju Seok Kim, Sun Hyung Kang, Eaum Seok Lee, Seok Hyun Kim, Jae Kyu Sung, Byung Seok Lee, Hyun Yong Jeong
BACKGROUND: Patients with a history of colonic resection for cancer have an increased risk for the development of metachronous malignant lesions. However, there is a lack of data on the detection rates of premalignant lesions during colonoscopy surveillance in these patients, and the few existing studies have shown conflicting results. AIMS: To identify the risk factor of metachronous premalignant lesions after colon cancer surgery. METHODS: We retrospectively screened consecutive patients who had undergone colonic surgery to treat colon cancer at the Chungnam National University Hospital between September 2009 and April 2014...
February 8, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29398398/recurrent-rotator-cuff-tear-is-ultrasound-imaging-reliable
#18
Ron Gilat, Ehud Atoun, Ornit Cohen, Oren Tsvieli, Ehud Rath, Dror Lakstein, Ofer Levy
BACKGROUND AND HYPOTHESIS: The diagnostic workup of the painful shoulder after rotator cuff repair (RCR) can be quite challenging. The aim of this study was to assess the reliability of ultrasonography (US) for the detection of recurrent rotator cuff tears in patients with shoulder pain after RCR. We hypothesized that US for the diagnosis of recurrent rotator cuff tear after RCR would not prove to be reliable when compared with surgical arthroscopic confirmation (gold standard). METHODS: In this cohort study (diagnosis), we retrospectively analyzed the data of 39 patients with shoulder pain after arthroscopic RCR who had subsequently undergone US, followed by revision arthroscopy...
February 2, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29397552/a-new-method-for-a-virtue-based-responsible-conduct-of-research-curriculum-pilot-test-results
#19
Eric Berling, Chet McLeskey, Michael O'Rourke, Robert T Pennock
Drawing on Pennock's theory of scientific virtues, we are developing an alternative curriculum for training scientists in the responsible conduct of research (RCR) that emphasizes internal values rather than externally imposed rules. This approach focuses on the virtuous characteristics of scientists that lead to responsible and exemplary behavior. We have been pilot-testing one element of such a virtue-based approach to RCR training by conducting dialogue sessions, modeled upon the approach developed by Toolbox Dialogue Initiative, that focus on a specific virtue, e...
February 3, 2018: Science and Engineering Ethics
https://www.readbyqxmd.com/read/29379581/erratum-to-infant-with-nasolacrimal-sinonasal-myxoma-diffusion-mri-features-radiology-case-reports-2015-10-article-1104
#20
Teresa Gross Kelly, Sang Hong, Jason Jarzembowski, David Beste
[This corrects the article DOI: 10.2484/rcr.v10i2.1104.].
March 2017: Radiology Case Reports
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