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https://www.readbyqxmd.com/read/28577850/chronic-myocardial-ischemia-leads-to-loss-of-maximal-oxygen-consumption-and-complex-i-dysfunction
#1
David A Schipper, Ryan Palsma, Katherine M Marsh, Connor O'Hare, Destiny S Dicken, Scott Lick, Toshinobu Kazui, Kitsie Johnson, Ryszard T Smolenski, Dirk J Duncker, Zain Khalpey
BACKGROUND: Cardiomyocytes rely heavily on mitochondrial energy production through oxidative phosphorylation. Chronic myocardial ischemia may cause mitochondrial dysfunction and affect ATP formation. Metabolic changes due to ischemia alters cardiac bioenergetics and hence myocardial function and overall bioenergetic state. Here, we evaluate differences in functional status of respiratory complexes in mitochondrial isolates extracted from left atrial appendage tissue (LAA) from patients undergoing cardiac surgery, with and without chronic ischemia...
June 1, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28575470/liver-mitochondrial-dysfunction-and-electron-transport-chain-defect-induced-by-high-dietary-copper-in-broilers
#2
Fan Yang, Huabin Cao, Rongsheng Su, Jianying Guo, Chengmei Li, Jiaqiang Pan, Zhaoxin Tang
Copper is an important trace mineral in the diet of poultry due to its biological activity. However, limited information is available concerning the effects of high copper on mitochondrial dysfunction. In this study, 72 broilers were used to investigate the effects of high dietary copper on liver mitochondrial dysfunction and electron transport chain defect. Birds were fed with different concentrations [11, 110, 220, and 330 mg of copper/kg dry matter (DM)] of copper from tribasic copper chloride (TBCC). The experiment lasted for 60 d...
June 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28572055/estrogen-regulates-spatially-distinct-cardiac-mitochondrial-subpopulations
#3
Rogério Faustino Ribeiro Junior, Paula Lopes Rodrigues, Elis Aguiar Morra, Karoline Sousa Ronconi, Patrícia Ribeiro Do Val Lima, Marcella Leite Porto, Maylla Ronacher Simões, Dalton Valentim Vassallo, Suely Gomes Figueiredo, Ivanita Stefanon
Increased susceptibility to permeability transition pore (mPTP) is a significant concern to decreased cardiac performance in postmenopausal females. The goal of this study was to assess the effects of estrogen deficiency on the two spatially distinct mitochondrial subpopulations from left ventricle: subsarcolemmal mitochondria (SSM) and intermyofibrillar mitochondria (IFM) based on: morphology, membrane potential, oxidative phosphorylation, mPTP and reactive oxygen species production. Female rats (8weeks old) that underwent bilateral ovariectomy were randomly assigned to receive daily treatment with placebo (OVX), estrogen replacement (OVX+E2) and Sham for 60days...
May 29, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28571723/opioid-consumption-after-rotator-cuff-repair
#4
Robert W Westermann, Chris A Anthony, Nic Bedard, Natalie Glass, Matt Bollier, Carolyn M Hettrich, Brian R Wolf
PURPOSE: Rising perioperative opioid use in the United States is of increasing concern. The purposes of this study were (1) to define opioid consumption after rotator cuff repair (RCR) in the United States and (2) to evaluate patient factors that may be associated with prolonged opioid use after arthroscopic RCR. METHODS: All arthroscopic RCRs performed between 2007 and 2014 were identified by use of Current Procedural Terminology code (29,827). Patients who filled opioid prescriptions preoperatively were divided into those who filled prescriptions at 1 to 3 months preceding RCR and those who filled opioid prescriptions only in the 1 month preceding RCR...
May 29, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28559438/article-level-assessment-of-influence-and-translation-in-biomedical-research
#5
George M Santangelo
Given the vast scale of the modern scientific enterprise, it can be difficult for scientists to make judgments about the work of others through careful analysis of the entirety of the relevant literature. This has led to a reliance on metrics that are mathematically flawed and insufficiently diverse to account for the variety of ways in which investigators contribute to scientific progress. An urgent, critical first step in solving this problem is replacing the Journal Impact Factor with an article-level alternative...
June 1, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28530504/functional-recovery-after-rotator-cuff-repair-the-role-of-biceps-surgery
#6
Bernardo Gialanella, Francesco Grossetti, Marina Mazza, Laura Danna, Laura Comini
CONTEXT: Surgical cuff repair is indicated in full-thickness rotator cuff tear when non-operative treatment fails. Surgical cuff repair can comprehend surgery of long head of the biceps when concomitant biceps pathology is present. However, the studies executed up to now do not have yet clearly defined if additional biceps surgery affects the shoulder functionality in patients who underwent rotator cuff repair. OBJECTIVE: The aim of this study is to verify if the concomitant biceps surgery prejudices the shoulder functionality during the short-term period in rotator cuff repair patients...
May 22, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28503724/root-resorption-during-orthodontic-treatment-with-invisalign%C3%A2-a-radiometric-study
#7
Giulia Gay, Serena Ravera, Tommaso Castroflorio, Francesco Garino, Gabriele Rossini, Simone Parrini, Giovanni Cugliari, Andrea Deregibus
BACKGROUND: Root resorption (RR) is described as a permanent loss of tooth structure from the root apex. Many reports in the literature indicate that orthodontically treated patients are more likely to have severe apical root shortening, interesting mostly maxillary, followed by mandibular incisors. The aim of the study was to investigate the incidence and severity of RR in adult patients treated with aligners. The study group consisted of 71 class I adult healthy patients (mean age 32...
December 2017: Progress in Orthodontics
https://www.readbyqxmd.com/read/28478897/one-stage-surgical-treatment-for-concomitant-rotator-cuff-tears-with-shoulder-stiffness-has-comparable-results-with-isolated-rotator-cuff-tears-a-systematic-review
#8
REVIEW
Soheil Sabzevari, Amir Reza Kachooei, Juan Giugale, Albert Lin
BACKGROUND: Addressing preoperative shoulder stiffness before rotator cuff repair (RCR) is advocated, but the effectiveness of this approach is debatable. We hypothesized that 1-stage treatment of concomitant rotator cuff tear (RCT) with shoulder stiffness has comparable results with isolated RCT. METHODS: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, the databases including MEDLINE, Embase, Cochrane Library, and Scopus were searched using the keywords of "shoulder stiffness" OR "adhesive capsulitis" OR "frozen shoulder" AND "rotator cuff...
May 3, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28451621/is-there-an-association-between-the-critical-shoulder-angle-and-clinical-outcome-after-rotator-cuff-repair
#9
Jacob M Kirsch, Amit Nathani, Christopher B Robbins, Joel J Gagnier, Asheesh Bedi, Bruce S Miller
BACKGROUND: Variations in scapular morphology have been associated with the development of atraumatic rotator cuff tears (RCTs). The critical shoulder angle (CSA) accounts for both glenoid inclination and lateral extension of the acromion. The impact of the CSA on outcomes after rotator cuff repair (RCR) has not been investigated previously. HYPOTHESIS: Our hypothesis was that individuals with smaller CSAs will have better patient-reported outcome scores over time compared with those with larger CSAs...
April 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28432515/mri-predicts-pathologic-complete-response-in-her2-positive-breast-cancer-after-neoadjuvant-chemotherapy
#10
Mette S van Ramshorst, Claudette E Loo, Emilie J Groen, Gonneke H Winter-Warnars, Jelle Wesseling, Frederieke van Duijnhoven, Marie-Jeanne T Vrancken Peeters, Gabe S Sonke
BACKGROUND: Neoadjuvant treatment of HER2-positive breast cancer frequently leads to a pathologic complete response (pCR), which is associated with favourable long-term outcome. Treatment regimens typically consist of 6-9 cycles of trastuzumab-based chemotherapy, although many patients achieve early radiologic complete response (rCR). If rCR accurately predicts pCR, the number of chemotherapy cycles can possibly be reduced. METHODS: We performed a diagnostic accuracy study to determine the association between rCR and pCR in patients with stage II-III HER2-positive breast cancer treated with neoadjuvant trastuzumab-based chemotherapy at the Netherlands Cancer Institute...
April 21, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28431580/cripto-1-acts-as-a-functional-marker-of-cancer-stem-like-cells-and-predicts-prognosis-of-the-patients-in-esophageal-squamous-cell-carcinoma
#11
Qiang Liu, Xiang Cui, Xi Yu, Bai-Shi-Jiao Bian, Feng Qian, Xu-Gang Hu, Cheng-Dong Ji, Lang Yang, Yong Ren, Wei Cui, Xia Zhang, Peng Zhang, Ji Ming Wang, You-Hong Cui, Xiu-Wu Bian
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is highly malignant with highly invasive and metastatic capabilities and poor prognosis. It is believed that the ESCC cancer stem-like cells (ECSLCs) are critical for tumorigenicity, invasion and metastasis of ESCC. However, the properties of ECSLCs vary with different markers used in isolation, so that new and more effective markers of ECSLCs need to be identified. This study aimed to estimate the potentiality of Cripto-1 (CR-1) as an ECSLC surface marker and investigate the clinical significance of CR-1 expression in ESCC...
April 21, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28421888/instructions-to-prospective-authors-by-indian-biomedical-journals-an-opportunity-to-promote-responsible-conduct-of-research
#12
Anup Bhat, Akash Shah, Swathi G Sherighar
Journals provide instructions to prospective authors to facilitate the process of manuscript publication. The information provided under such instructions could be a potential opportunity to promote responsible conduct of research (RCR). We analyzed 74 Indian biomedical journals for the type of information provided in the "instructions to authors" section and adherence to the International Committee of Medical Journal Editors (ICMJE) recommendations. Among the 71 journals that had an "instructions to authors" section, 53 journals adhered to ICMJE recommendations...
April 2017: Journal of Empirical Research on Human Research Ethics: JERHRE
https://www.readbyqxmd.com/read/28352320/fungal-infection-involvement-in-primary-biliary-cirrhosis-a-review-of-2-cases
#13
Yanyan Wang, Zheng Zhao, Hui Lu, Jianglin Zhang, Feng Huang
The present study aimed to analyze the imaging, clinical and pathological features of fungal infection involvement in primary biliary cirrhosis (PBC) by retrospectively analyzing and reviewing the features of two patients with fungal infection involvement in PBC. Both patients were female. One patient had a confirmed diagnosis of PBC. The other patient had confirmed Sjogren syndrome and PBC. The two cases of PBC were infected with fungal infection after treatment with hormonal and immunosuppressive agents. RCR of sputum confirmed Pneumocystis spp...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28351553/performance-assessment-of-arthroscopic-rotator-cuff-repair-and-labral-repair-in-a-dry-shoulder-simulator
#14
Tim Dwyer, Rachel Schachar, Tim Leroux, Massimo Petrera, Jeffrey Cheung, Rachel Greben, Patrick Henry, Darrell Ogilvie-Harris, John Theodoropoulos, Jaskarndip Chahal
PURPOSE: To evaluate the use of dry models to assess performance of arthroscopic rotator cuff repair (RCR) and labral repair (LR). METHODS: Residents, fellows, and sports medicine staff performed an arthroscopic RCR and LR on a dry model. Any prior RCR and LR experience was noted. Staff surgeons assessed participants by use of task-specific checklists, the Arthroscopic Surgical Skill Evaluation Tool (ASSET), and a final overall global rating. All procedures were video recorded and were scored by a fellow blinded to the year of training of each participant...
March 25, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28336230/the-effect-of-concomitant-biceps-tenodesis-on-reoperation-rates-after-rotator-cuff-repair-a%C3%A2-review-of-a-large-private-payer-database-from-2007-to-2014
#15
Brandon J Erickson, Bryce A Basques, Justin W Griffin, Samuel A Taylor, Stephen J O'Brien, Nikhil N Verma, Anthony A Romeo
PURPOSE: To determine if reoperation rates are higher for patients who underwent isolated rotator cuff repair (RCR) than those who underwent RCR with concomitant biceps tenodesis using a large private-payer database. METHODS: A national insurance database was queried for patients who underwent arthroscopic RCR between the years 2007 and 2014 (PearlDiver, Warsaw, IN). The Current Procedural Terminology (CPT) 29,827 (arthroscopy, shoulder, surgical; with RCR) identified RCR patients who were subdivided into 3 groups-group 1: RCR without biceps tenodesis; group 2: RCR with concomitant arthroscopic biceps tenodesis (CPT 29827 and 29,828); group 3: RCR with concomitant open biceps tenodesis (CPT 29827 and 23,430)...
March 20, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28335095/genetic-correlation-between-live-body-measurements-and-beef-cutability-traits-in-hanwoo-steers
#16
Yun Ho Choy, Jae Goo Lee, Alam Mahboob, Tae Jeong Choi, Seung Hee Rho
The growth, carcass and retail cut yield records on 1,428 Hanwoo steers obtained through progeny testing were analyzed in this study, and their heritability and genetic relationships among the traits were estimated using animal models. Two different models were compared in this study. Each model was fitted for different fixed class effects, date of slaughter for carcass traits and batch of progeny test live measurement traits, and a choice of covariates (carcass weight in Model 1 or backfat thickness in Model 2) for carcass traits...
March 21, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28332862/effective-practices-in-the-delivery-of-research-ethics-education-a-qualitative-review-of-instructional-methods
#17
E Michelle Todd, Brett S Torrence, Logan L Watts, Tyler J Mulhearn, Shane Connelly, Michael D Mumford
In order to delineate best practices for courses on research ethics, the goal of the present effort was to identify themes related to instructional methods reflected in effective research ethics and responsible conduct of research (RCR) courses. By utilizing a qualitative review, four themes relevant to instructional methods were identified in effective research ethics courses: active participation, case-based activities, a combination of individual and group approaches, and a small number of instructional methods...
2017: Accountability in Research
https://www.readbyqxmd.com/read/28302481/metformin-improves-cardiac-function-in-mice-with-heart-failure-after-myocardial-infarction-by-regulating-mitochondrial-energy-metabolism
#18
Dan Sun, Fei Yang
To investigate whether metformin can improve the cardiac function through improving the mitochondrial function in model of heart failure after myocardial infarction. Male C57/BL6 mice aged about 8 weeks were selected and the anterior descending branch was ligatured to establish the heart failure model after myocardial infarction. The cardiac function was evaluated via ultrasound after 3 days to determine the modeling was successful, and the mice were randomly divided into two groups. Saline group (Saline) received the intragastric administration of normal saline for 4 weeks, and metformin group (Met) received the intragastric administration of metformin for 4 weeks...
April 29, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28299561/america-competes-at-5%C3%A2-years-an-analysis-of-research-intensive-universities-rcr-training-plans
#19
Trisha Phillips, Franchesca Nestor, Gillian Beach, Elizabeth Heitman
This project evaluates the impact of the National Science Foundation's (NSF) policy to promote education in the responsible conduct of research (RCR). To determine whether this policy resulted in meaningful RCR educational experiences, our study examined the instructional plans developed by individual universities in response to the mandate. Using a sample of 108 U.S. institutions classified as Carnegie "very high research activity", we analyzed all publicly available NSF RCR training plans in light of the consensus best practices in RCR education that were known at the time the policy was implemented...
March 15, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28293547/proinflammatory-response-induced-by-newcastle-disease-virus-in-tumor-and-normal-cells
#20
Teridah Ernala Ginting, Jeremiah Suryatenggara, Salomo Christian, George Mathew
PURPOSE: To investigate the specific role of immune responses induced by lentogenic Newcastle disease virus (NDV) for its antitumor effect. MATERIALS AND METHODS: NDV LaSota strain was used to infect the following human cells: non-small cell lung carcinoma (A549), glioblastoma (U87MG and T98G), mammary gland adenocarcinoma (MCF7 and MDA-MB-453), hepatocellular carcinoma (Huh7), transformed embryonic kidney cells (HEK293), primary monocytes, lung fibroblast (HF19), skin fibroblast (NB1RGB) and rat astroglia (RCR-1) at 0...
2017: Oncolytic Virotherapy
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