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Neonatal parenteral nutrition

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https://www.readbyqxmd.com/read/29921470/ttc7a-mutation-must-be-considered-in-patients-with-repeated-intestinal-atresia-associated-with-early-inflammatory-bowel-disease-two-new-case-reports-and-a-literature-review
#1
J Fayard, S Collardeau, Y Bertrand, M-P Cordier, C Malcus, R Dubois, P-Y Mure, G de Saint Basile, T Louazon, B Rohmer, A Lachaux, R Duclaux, N Peretti
TTC7A mutations cause multiple neonatal intestinal atresias with early inflammatory bowel disease and severe combined immunodeficiency. There are no treatment protocols for this rare disease. Two new cases are described for which radical early treatment measures - total enterectomy, home parenteral nutrition, immunoglobulin therapy and intravenous antibiotic prophylaxis - have allowed both patients to develop optimally.
June 16, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29912684/large-outbreaks-of-fungal-and-bacterial-bloodstream-infections-in-a-neonatal-unit-south-africa-2012-2016
#2
Erika van Schalkwyk, Samantha Iyaloo, Serisha D Naicker, Tsidiso G Maphanga, Ruth S Mpembe, Thokozile G Zulu, Mabatho Mhlanga, Sibongile Mahlangu, Motlatji B Maloba, Grace Ntlemo, Kgomotso Sanyane, Dini Mawela, Nelesh P Govender
Candidemia is a major cause of healthcare-associated infections. We describe a large outbreak of Candida krusei bloodstream infections among infants in Gauteng Province, South Africa, during a 4-month period; a series of candidemia and bacteremia outbreaks in the neonatal unit followed. We detected cases by using enhanced laboratory surveillance and audited hospital wards by environmental sampling and epidemiologic studies. During July-October 2014, among 589 patients, 48 unique cases of C. krusei candidemia occurred (8...
July 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29894475/neonatal-factors-related-to-center-variation-in-the-incidence-of-late-onset-circulatory-collapse-in-extremely-preterm-infants
#3
Yume Suzuki, Yumi Kono, Takahiro Hayakawa, Hironori Shimozawa, Miyuki Matano, Yukari Yada
BACKGROUND: Although late-onset circulatory collapse (LCC) is widely recognized in Japan, its etiology and the reason for center variation in its incidence remain unclear. This study's objectives were to identify the perinatal and neonatal factors related to LCC and to estimate the factors related to the center variation in the incidence of LCC. METHODS: Extremely preterm infants born between 2008 and 2012 who were registered in the database of the Neonatal Research Network, Japan were retrospectively analyzed...
2018: PloS One
https://www.readbyqxmd.com/read/29888413/trends-in-late-onset-sepsis-in-a-neonatal-intensive-care-unit-following-implementation-of-infection-control-bundle-a-15-year-audit
#4
Pramod Pharande, Kwee B Lindrea, John Smyth, Margaret Evans, Kei Lui, Srinivas Bolisetty
AIM: Late-onset sepsis (LOS) is a frequent and important cause of morbidity and mortality in newborn infants admitted to neonatal intensive care units (NICUs). The objective of this study is to evaluate the impact of various infection control quality measures introduced as a bundle on the trends of the LOS in a NICU. METHODS: This was a prospective quality improvement study involving all neonates admitted to a NICU over a 15-year period between 2002 and 2016. The main focus areas of the bundle included collaborative team effort, hand hygiene, education, central line insertion and maintenance bundles and parenteral nutrition...
June 11, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29880397/primary-versus-secondary-anastomosis-in-intestinal-atresia
#5
Margot M Hillyer, Katherine J Baxter, Matthew S Clifton, Scott E Gillespie, Leah N Bryan, Curtis D Travers, Mehul V Raval
PURPOSE: Neonates with intestinal atresia (IA) undergo either primary anastomosis (PA) or ostomy creation with secondary anastomosis (SA). Our purpose was to compare outcomes for PA and SA and to assess factors influencing procedure selection. METHODS: We conducted a retrospective cohort study of neonates with IA between 2009 and 2015. Patient characteristics, operative details, and outcomes were collected. Surgeon-level preferences (defined as performing >50% PA or SA) were assessed using logistic regression...
May 15, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29874829/iron-promotes-intestinal-development-in-neonatal-piglets
#6
Yutian Pu, Shuhui Li, Haitao Xiong, Xiaofeng Zhang, Yizhen Wang, Huahua Du
Early nutrition is key to promoting gut growth and education of the immune system. Although iron deficiency anemia has long been recognized as a serious iron disorder, the effects of iron supplementation on gut development are less clear. Therefore, using suckling piglets as the model for iron deficiency, we assessed the impacts of iron supplementation on hematological status, gut development, and immunity improvement. Piglets were parenterally supplied with iron dextran (FeDex, 60 mg Fe/kg) by intramuscular administration on the third day after birth and slaughtered at the age of two days, five days, 10 days, and 20 days...
June 5, 2018: Nutrients
https://www.readbyqxmd.com/read/29871471/feeding-dysfunctions-and-failure-to-thrive-in-neonates-with-congenital-heart-diseases
#7
Giovanna Mangili, Elena Garzoli, Youcef Sadou
Congenital heart disease (CHD) is the most common neonatal congenital malformation. The variety and severity of clinical presentation depend on the cardiac structures involved and their functional impact. The management of newborns with CHD requires a multidisciplinary approach, in which the nutritional aspect plays an important role. An adequate caloric intake during either preand post-surgical period, in fact, improves the outcome of these patients. In addition, the failure to thrive of these children in childhood has been related to long-term cognitive delay (attention deficit disorders, aggressive behaviour and poor social and emotional development)...
May 23, 2018: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
https://www.readbyqxmd.com/read/29867048/aluminum-exposure-from-parenteral-nutrition-early-bile-canaliculus-changes-of-the-hepatocyte
#8
Amanda R Hall, Ha Le, Chris Arnold, Janet Brunton, Robert Bertolo, Grant G Miller, Gordon A Zello, Consolato Sergi
Background: Neonates on long-term parenteral nutrition (PN) may develop parenteral nutrition-associated liver disease (PNALD). Aluminum (Al) is a known contaminant of infant PN, and we hypothesize that it substantially contributes to PNALD. In this study, we aim to assess the impact of Al on hepatocytes in a piglet model. Methods: We conducted a randomized control trial using a Yucatan piglet PN model. Piglets, aged 3⁻6 days, were placed into two groups. The high Al group ( n = 8) received PN with 63 µg/kg/day of Al, while the low Al group ( n = 7) received PN with 24 µg/kg/day of Al...
June 4, 2018: Nutrients
https://www.readbyqxmd.com/read/29863424/clinical-implications-of-umbilical-artery-doppler-changes-after-betamethasone-administration
#9
Nandini Raghuraman, Bree Porcelli, Lorene Temming, George Macones, Alison Cahill, Methodius Tuuli, Jeffrey M Dicke
BACKGROUND: Betamethasone (BMZ) is commonly administered to patients with fetal growth restriction (FGR) and abnormal umbilical artery Doppler velocimetry (UAD) due to the increased risk of preterm delivery; however, the clinical impact of UAD changes after BMZ exposure is unknown. OBJECTIVE: To test the hypothesis that lack of UAD improvement after BMZ administration is associated with shorter latency and greater neonatal morbidity in patients with FGR. STUDY DESIGN: This was a retrospective cohort study of pregnancies complicated by FGR and abnormal UAD between 240 -336 weeks gestation...
June 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29790700/early-hypophosphatemia-in-very-low-birth-weight-preterm-infants
#10
REVIEW
Agata Pająk, Barbara Królak-Olejnik, Agnieszka Szafrańska
Refeeding Syndrome (RFS) is a well-known group of symptoms which occur after the introduction of enteral or parenteral nutrition in undernourished patients. Intrauterine growth restriction (IUGR) is the equivalent of postnatal RFS following the beginning of feeding. The aggressive parenteral nutrition of neonates with very low birth weight (VLBW) resulting from the termination of intrauterine transplacental nutrition is a source of biochemical disorders. The aim of this study was to analyze metabolic disorders in preterm infants during the 1st week of life and to determine the hypophosphatemia risk factors in low birth weight neonates receiving parenteral nutrition...
May 21, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29770842/clinical-features-and-practice-patterns-of-gastroschisis-a-retrospective-analysis-using-a-japanese-national-inpatient-database
#11
Michimasa Fujiogi, Nobuaki Michihata, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga, Jun Fujishiro
PURPOSE: The number of infants with gastroschisis is increasing worldwide, but advances in neonatal intensive care and parenteral nutrition have reduced gastroschisis mortality. Recent clinical data on gastroschisis are often from Western nations. This study aimed to examine clinical features and practice patterns of gastroschisis in Japan. METHODS: We examined treatment options, outcomes, and discharge status among inpatients with simple gastroschisis (SG) and complex gastroschisis (CG), 2010-2016, using a national inpatient database in Japan...
May 16, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29715193/severe-lactic-acidosis-in-an-extremely-low-birth-weight-infant-due-to-thiamine-deficiency
#12
Hulya Ozdemir, Hulya Bilgen, Zeynep Alp Unkar, Ertugrul Kiykim, Asli Memisoglu, Eren Ozek
BACKGROUND: In this case report, we present a preterm newborn with persistent lactic acidosis who received total parenteral nutrition (TPN) that lacked thiamine. CASE PRESENTATION: A 28-week-old, 750 g female infant was born with an Apgar score of 8 at the 5th minute. Umbilical cord blood gas levels, including lactate level, were normal, and she was admitted to our neonatal intensive care unit (NICU). Achieving full enteral feeding was not possible due to gastric residues and abdominal distention, making the patient dependent on TPN during the first 2 weeks of life...
June 27, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29709288/is-the-bishop-koop-procedure-useful-in-severe-jejunoileal-atresia
#13
Yanfen Peng, Haiqing Zheng, Qiuming He, Zhe Wang, Hong Zhang, Puja Bk Chaudhari, Wei Zhong, Jiakang Yu
PURPOSE: The aim of this study was to report our experience using the Bishop-Koop procedure for the treatment of various surgical problems of jejunoileal atresia including luminal discrepancy, complex meconium peritonitis, type IIIb and type IV atresia which we defined as severe jejunoileal atresia. METHODS: This retrospective study was performed on the patients with severe jejunoileal atresia who underwent Bishop-Koop procedure at a tertiary center in China over a five year of period...
April 5, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29701872/management-of-ready-to-use-parenteral-nutrition-in-newborns-systematic-review
#14
REVIEW
Karen Daniela Romero Mena, Olga Lucia Pinzón Espitia, José Alejandro Daza Vergara
Parenteral support has increased the possibility of neonatal recovery. However, complications associated with its use have been documented. One commercial method developed to decrease the complications of this type of support is the ready-to-use parenteral nutrition (PN), a 3-chamber bag that provides a complete nutrient mix. This systematic review seeks, through the Preferred Reporting Items for Systematic Reviews and Meta-Analyses methodology, to establish the benefits in newborns. Seven databases and gray literature were used...
April 27, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29689751/effect-of-standardized-feeding-protocol-on-nutrient-supply-and-postnatal-growth-of-preterm-infants-a-prospective-study
#15
Z Khan, N Morris, H Unterrainer, N Haiden, S J Holasek, B Urlesberger
BACKGROUND: Preterm birth is a medical emergency and it is becoming evident that adequate nutrition starting in the first hours of life is of major importance for short and even more so for long-term health outcomes of the premature newborn. The aim was to analyze postnatal nutrient supply and growth patterns of preterm infants in response to a standardized feeding protocol during stay at neonatal intensive care unit (NICU). METHODS: A prospective cohort study was conducted at NICU, Children Hospital Graz...
2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29689743/extravasation-of-total-parenteral-nutrition-into-the-liver-from-an-upper-extremity-peripherally-inserted-central-venous-catheter
#16
Arpit Gupta, Alok Bhutada, Miheret Yitayew, Shantanu Rastogi
Peripherally inserted central catheters (PICC) are the mainstay of central venous access in preterm infants, and one of the common procedures performed in neonatal intensive care unit (NICU). Complications of PICC include infection, mechanical dysfunction, thrombosis, migration, and extravasation of the infusate. In this report, we describe a case of PICC inserted from an upper extremity with migration into the inferior vena cava (IVC) and the hepatic vein associated with extravasation of the total parenteral nutrition (TPN) into the peritoneum and the liver...
2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29683522/magnifying-lenses-to-aid-umbilical-catheter-insertion
#17
Aisling M O'Riordan, Oksana Kozdoba, John Fa Murphy, Lisa K McCarthy
No abstract text is available yet for this article.
April 23, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29666098/a-misplaced-peripherally-inserted-central-catheter-presenting-as-contralateral-pleural-effusion
#18
Jogender Kumar, Sudeep K C, Kanya Mukhopadhyay, Somosri Ray
A preterm neonate born at 27 weeks, with a birth weight of 555 g, was on continuous positive airway pressure (CPAP) for apnoea of prematurity and initially received total parenteral nutrition (TPN) through the umbilical venous catheter. Peripherally inserted central catheter (PICC) was inserted in the left basilica vein on day 8 to continue TPN. The baby developed respiratory distress with persistent hypoxia after TPN was initiated through the PICC line. The baby required mechanical ventilation due to worsening of respiratory distress, and chest X-ray, as well as ultrasound conducted 12 hours, postinfusion of TPN revealed right-sided pleural effusion...
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29628208/complex-gastroschisis-clinical-spectrum-and-neonatal-outcomes-at-a-referral-center
#19
Pablo Laje, Maria V Fraga, William H Peranteau, Holly L Hedrick, Nahla Khalek, Juliana S Gebb, Julie S Moldenhauer, Mark P Johnson, Alan W Flake, N Scott Adzick
AIM OF THE STUDY: To evaluate the outcomes of neonates with complex gastroschisis (GC), and correlate outcomes with each type of complication. METHODS: Retrospective review of patients with complex GC owing to prenatal and/or postnatal abdominal complications; 2008-2016. Primary outcomes: time to discontinue parenteral nutrition (off-PN), length of stay (LOS) and neonatal survival. MAIN RESULTS: We treated 58 patients with complex gastroschisis owing to abdominal complications, which were: intestinal necrosis at birth (n=9), intestinal atresia (n=16), medical necrotizing enterocolitis (NEC) (n=15), surgical NEC (n=1), in utero volvulus (n=1), vanishing gastroschisis (n=2), severe intestinal dysmotility (n=1), delayed abdominal closure (n=3), abdominal compartment syndrome (n=2) and hiatal hernia/severe gastroesophageal reflux disease (GERD; n=11)...
March 14, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29615158/reduction-in-central-line-associated-bloodstream-infections-in-a-nicu-practical-lessons-for-its-achievement-and-sustainability
#20
Judith A Hawes, Kyong-Soon Lee
Central venous catheters are commonly used for the provision of parenteral nutrition and medications for critically ill neonates in the NICU. However, central line-associated bloodstream infections (CLABSIs) are a major complication associated with their use and remain an important cause of nosocomial sepsis in NICUs. Central line-associated bloodstream infection has shifted from being an expected routine complication of central line use to an adverse event now evaluated as a critical event with the goal of identifying root causes so future CLABSI events are prevented...
March 1, 2018: Neonatal Network: NN
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