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Neonatal parenteral nutrition

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https://www.readbyqxmd.com/read/29445923/inpatient-outcomes-of-preterm-infants-receiving-%C3%AF-3-enriched-lipid-emulsion-smoflipid-an-observational-study
#1
Nalin Choudhary, Kenneth Tan, Atul Malhotra
Neonatal units have started to switch from using conventional soy-based to alternate lipid emulsions, like SMOFlipid. SMOFlipid has been associated with an improvement in biochemical parameters and delays progression of parenteral nutrition-associated liver disease (PNALD). This retrospective epoch study aimed to compare clinically relevant neonatal outcomes in preterm infants (< 32 weeks), receiving SMOFlipid versus Intralipid. We compared clinical outcomes in two epochs-epoch 1 (Intralipid, October 2013-June 2015) versus epoch 2 (SMOFlipid, July 2015-March 2017)...
February 14, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29443921/calcium-chloride-and-calcium-gluconate-in-neonatal-parenteral-nutrition-solutions-without-cysteine-compatibility-studies-using-laser-light-obscuration-methodology
#2
Robert K Huston, J Mark Christensen, Sultan M Alsharhani, Sumeia M Mohamed, Carl F Heisel
There are no compatibility studies for neonatal parenteral nutrition solutions without cysteine containing calcium chloride or calcium gluconate using light obscuration as recommended by the United States Pharmacopeia (USP). The purpose of this study was to do compatibility testing for solutions containing calcium chloride and calcium gluconate without cysteine. Solutions of TrophAmine and Premasol (2.5% amino acids), containing calcium chloride or calcium gluconate were compounded without cysteine. Solutions were analyzed for particle counts using light obscuration...
February 14, 2018: Nutrients
https://www.readbyqxmd.com/read/29426398/corrigendum-to-total-parenteral-nutrition-for-the-very-low-birth-weight-infant-semin-fetal-neonatal-med-2017-22-1-2-7
#3
Pinkal Patel, Jatinder Bhatia
No abstract text is available yet for this article.
February 2018: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29417204/the-influence-of-gestational-age-mode-of-delivery-and-abdominal-wall-closure-method-on-the-surgical-outcome-of-neonates-with-uncomplicated-gastroschisis
#4
Maria V Fraga, Pablo Laje, William H Peranteau, Holly L Hedrick, Nahla Khalek, Juliana S Gebb, Julie S Moldenhauer, Mark P Johnson, Alan W Flake, N Scott Adzick
AIM OF THE STUDY: To evaluate if gestational age (GA), mode of delivery and abdominal wall closure method influence outcomes in uncomplicated gastroschisis (GTC). METHODS: Retrospective review of NICU admissions for gastroschisis, August 2008-July 2016. Primary outcomes were: time to start enteral feeds (on-EF), time to discontinue parenteral nutrition (off-PN), and length of stay (LOS). MAIN RESULTS: A total of 200 patients with GTC were admitted to our NICU...
February 7, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29415837/parenteral-nutrition-associated-cholestasis-and-triglyceridemia-in-surgical-term-and-near-term-neonates-a-pilot-randomized-controlled-trial-of-two-mixed-intravenous-lipid-emulsions
#5
Luís Pereira-da-Silva, Sara Nóbrega, Maria Luísa Rosa, Marta Alves, Ana Pita, Daniel Virella, Ana Luísa Papoila, Micaela Serelha, Gonçalo Cordeiro-Ferreira, Berthold Koletzko
BACKGROUND: Cholestasis is a common complication in infants receiving prolonged parenteral nutrition (PN). We studied the effects of two intravenous lipid emulsions composed with either 30% soybean oil, 30% medium-chain triglycerides (MCT), 25% olive oil, and 15% fish oil (SMOF) or with 50% MCT and 50% soybean oil n-6 (MCT/SOY) on the incidence of cholestasis in surgical term and near-term neonates. METHODS: A single-center, double-blinded, randomized controlled trial compared the incidence of cholestasis using either SMOF or MCT/SOY in neonates born at gestational age ≥34 weeks undergoing major surgery...
December 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29406002/mineral-homeostasis-and-effects-on-bone-mineralization-in-the-preterm-neonate
#6
REVIEW
Heidi E Karpen
Most bone formation and mineralization occurs late in gestation. Accretion of adequate minerals is a key element of this process and is often interrupted through preterm birth. In utero, mineral transport is accomplished via active transport across the placenta and does not require fetal hormone input. Postnatal mineral homeostasis requires a balance of actions of parathyroid hormone, calcitonin, and vitamin D on target organs. Preterm birth, asphyxia, acidosis, and prolonged parenteral nutrition increase the risk of mineral imbalance and metabolic bone disease (MBD)...
March 2018: Clinics in Perinatology
https://www.readbyqxmd.com/read/29395015/-physicochemical-stability-of-individualized-parenteral-nutrition-in-neonatal-period
#7
J Lombardi, D S Semama
Individualized parenteral nutrition is frequently used in neonatal period because of specific nutritional needs of preterm neonates which are not always covered by industrially produced parenteral nutrition. This review summarizes the risks of physicochemical instability associated with parenteral nutrition preparation in order to make recommendations to secure this mode of preparation.
March 2018: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/29390542/particularities-of-the-management-and-the-treatment-in-a-rare-sepsis-with-candida-tropicalis-of-a-collodion-baby-case-report
#8
Alina Mariela Murgu, Irina Geanina Crişcov, Silvia Fotea, Ginel Baciu, Anca Chiriac, Elena Tarca, Violeta Streanga
RATIONALE: Collodion baby is a rare autosomal recessive disorder. It can be the first expression of some forms of ichthyosis. PATIENT CONCERNS: The authors present the case of a newborn diagnosed with severe Collodion baby syndrome who required prolonged hospitalization in the intensive care unit because of infectious complications like the fungal sepsis and other bacterial superinfections. DIAGNOSES: The case has many diagnostic and therapeutic particularities and management difficulties...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29373986/etiological-heterogeneity-and-clinical-variability-in-newborns-with-esophageal-atresia
#9
Ettore Piro, Ingrid Anne Mandy Schierz, Mario Giuffrè, Giovanni Cuffaro, Simona La Placa, Vincenzo Antona, Federico Matina, Giuseppe Puccio, Marcello Cimador, Giovanni Corsello
BACKGROUND: The aim of this study was to define different characteristics of infants with esophageal atresia and correlations with neonatal level of care, morbidity and mortality occurring during hospital stay. METHODS: Charts of all newborns with esophageal atresia (EA) admitted to our University NICU between January 2003 and November 2016 were reviewed and subdivided in four groups related to different clinical presentations; EA as an isolated form (A), with a concomitant single malformation (B), as VACTERL association (C), and in the context of a syndrome or an entity of multiple congenital anomalies (D)...
January 26, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29364360/novel-multidisciplinary-approach-to-monitor-and-treat-fetuses-with-gastroschisis-using-the-svetliza-reducibility-index-and-the-exit-like-procedure
#10
Gustavo Henrique de Oliveira, Javier Svetliza, Denise Cristina Mós Vaz-Oliani, Humberto Liedtke Junior, Antonio Helio Oliani, Denise Araujo Lapa Pedreira
OBJECTIVE: To describe our initial experience with a novel approach to follow-up and treat gastroschisis in "zero minute" using the EXITlike procedure. METHODS: Eleven fetuses with prenatal diagnosis of gastroschisis were evaluated. The Svetliza Reductibility Index was used to prospectively evaluate five cases, and six cases were used as historical controls. The Svetliza Reductibility Index consisted in dividing the real abdominal wall defect diameter by the larger intestinal loop to be fitted in such space...
October 2017: Einstein
https://www.readbyqxmd.com/read/29338079/nutrition-delivery-and-growth-outcomes-in-infants-with-gastroschisis
#11
Charles R Hong, David Zurakowski, Brenna S Fullerton, Katelyn Ariagno, Tom Jaksic, Nilesh M Mehta
BACKGROUND: We aimed to describe nutrient intake and growth in infants with gastroschisis and identify factors associated with impaired growth. METHODS: Retrospective study of neonates who underwent gastroschisis repair from 2010 to 2015. Nutrient intake and weight-for-age z scores (WAZ) were recorded. RESULTS: Data from 60 eligible infants with median (Q1, Q3) gestational age of 36 weeks (35, 37) and birth weight 2418 g (2098, 2665) were analyzed...
January 8, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29298359/compatibility-of-intravenous-ibuprofen-with-lipids-and-parenteral-nutrition-for-use-as-a-continuous-infusion
#12
Jowell Garcia, Alka Garg, Yunmei Song, Ambados Fotios, Chad Andersen, Sanjay Garg
There is increasing interest to administer ibuprofen as a continuous infusion instead of a traditional bolus for treating Patent Ductus Arteriosus (PDA). However, its compatibility data with commonly used drugs in the neonatal period, including parenteral nutrition (PN) and lipids is unavailable. The aim is to determine the compatibility of intravenous ibuprofen lysine with various ANZNN parenteral nutrition consensus group standard neonatal PN formulations and lipids. The PN and lipid solutions used in a tertiary neonatal unit were obtained...
2018: PloS One
https://www.readbyqxmd.com/read/29286927/carnitine-deficiency-in-preterm-infants-a-national-survey-of-knowledge-and-practices
#13
M A Clark, R E K Stein, Ellen J Silver, Sabeen Khalid, M Fuloria, N V Esteban-Cruciani
OBJECTIVE: Lipid supplementation improves developmental outcomes in preterm infants. Carnitine is essential for lipid metabolism; however, despite high risk for carnitine deficiency, there are no standards for carnitine supplementation in preterm infants receiving total parenteral nutrition (TPN). Our objective was to assess knowledge, beliefs and practices regarding preterm carnitine deficiency and supplementation among neonatal practitioners. METHODS: Cross-sectional electronic survey administered via a nationally representative listserv of neonatal practitioners...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29240507/neonatal-jaundice-aetiology-diagnosis-and-treatment
#14
Subhabrata Mitra, Janet Rennie
A significant proportion of term and preterm infants develop neonatal jaundice. Jaundice in an otherwise healthy term infant is the most common reason for readmission to hospital. Jaundice is caused by an increase in serum bilirubin levels, largely as a result of breakdown of red blood cells. Bilirubin is conveyed in the blood as 'unconjugated' bilirubin, largely bound to albumin. The liver converts bilirubin into a conjugated form which is excreted in the bile. Very high levels of unconjugated bilirubin are neurotoxic...
December 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/29234596/exploring-the-multiple-hit-hypothesis-of-preterm-white-matter-damage-using-diffusion-mri
#15
Madeleine L Barnett, Nora Tusor, Gareth Ball, Andrew Chew, Shona Falconer, Paul Aljabar, Jessica A Kimpton, Nigel Kennea, Mary Rutherford, A David Edwards, Serena J Counsell
Background: Preterm infants are at high risk of diffuse white matter injury and adverse neurodevelopmental outcome. The multiple hit hypothesis suggests that the risk of white matter injury increases with cumulative exposure to multiple perinatal risk factors. Our aim was to test this hypothesis in a large cohort of preterm infants using diffusion weighted magnetic resonance imaging (dMRI). Methods: We studied 491 infants (52% male) without focal destructive brain lesions born at < 34 weeks, who underwent structural and dMRI at a specialist Neonatal Imaging Centre...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29217722/successfully-implementing-and-embedding-guidelines-to-improve-the-nutrition-and-growth-of-preterm-infants-in-neonatal-intensive-care-a-prospective-interventional-study
#16
Mark J Johnson, Alison A Leaf, Freya Pearson, Howard W Clark, Borislav D Dimitrov, Catherine Pope, Carl R May
OBJECTIVES: We aimed to improve the nutritional care of preterm infants by developing a complex (multifaceted) intervention intended to translate current evidence into practice. We used the sociological framework of Normalization Process Theory (NPT), to guide implementation in order to embed the new practices into routine care. DESIGN: A prospective interventional study with a before and after methodology. PARTICIPANTS: Infants <30 weeks gestation or <1500 g at birth...
December 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/29198897/the-idle-central-venous-catheter-in-the-nicu-when-should-it-be-removed
#17
Cristen N Litz, Jordan G Tropf, Paul D Danielson, Nicole M Chandler
PURPOSE: There is debate regarding the optimal timing of central line removal in the neonatal intensive care unit (NICU). The purpose was to evaluate outcomes of idle peripherally inserted central catheters (PICCs) and tunneled central venous catheters (TCVCs) and determine the incidence of line-related infections and replacements. METHODS: Patients in the NICU with T-CVCs placed between 11/2008 and 8/2015 (n=134) or PICCs placed between 7/2013 and 10/2015 (n=467) were included...
November 9, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29198532/impact-of-prolonged-mechanical-ventilation-in-very-low-birth-weight-infants-results-from-a-national-cohort-study
#18
Young-Bin Choi, Juyoung Lee, Jisun Park, Yong Hoon Jun
OBJECTIVE: To evaluate the in-hospital consequences of prolonged respiratory support with invasive mechanical ventilation in very low birth weight infants. STUDY DESIGN: A cohort study was performed using prospectively collected data from 69 neonatal intensive care units participating in the Korean national registry. In total, 3508 very low birth weight infants born between January 1, 2013 and December 31, 2014 were reviewed. RESULTS: The adjusted hazard ratio for death increased significantly for infants who received mechanical ventilation for more than 2 weeks compared with those were mechanically ventilated for 7 days or less...
November 30, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29184590/the-impact-of-an-educational-program-regarding-total-parenteral-nutrition-on-infection-indicators-in-neonates-admitted-to-the-neonatal-intensive-care-unit
#19
Maryam Marofi, Nahid Bijani, Zahra Abdeyazdan, Behzad Barekatain
Background: One of the basic care measures for preterm infants is providing nutrition through total parenteral nutrition (TPN) and one of the most important complications of it is infection. Because prevention of nosocomial infections is an important issue for neonate's safety, this study aimed to determine the effects of a continuing medical education (CME) course on TPN for neonatal intensive care unit (NICU) nurses on indicators of infection in newborns. Materials and Methods: This quasi-experimental study was conducted on 127 neonates who fulfilled the inclusion criteria...
November 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/29172239/strictly-controlled-glucose-infusion-rates-are-associated-with-a-reduced-risk-of-hyperglycaemia-in-extremely-low-birth-weight-preterm-infants
#20
Hans Jorgen Stensvold, Astri M Lang, Kenneth Strommen, Tore G Abrahamsen, Bjorn Ogland, Are H Pripp, Arild E Ronnestad
AIM: We evaluated a strict strategy that aimed to avoid fluctuations in glucose infusion rates (GIRs) and assessed the independent effects of maximal daily GIRs on the hyperglycaemia risk among extremely low birth weight (ELBW) infants receiving early enhanced parenteral nutrition. METHODS: This study comprised all ELBW infants admitted to the neonatal intensive care unit of Oslo University Hospital Rikshospitalet, Norway, before (2007-2009) and after (2012-2013) implementing a strict GIR strategy...
November 24, 2017: Acta Paediatrica
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