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https://www.readbyqxmd.com/read/29040219/effect-of-2-years-of-endurance-and-high-impact-training-on-preventing-osteoporosis-in-postmenopausal-women-randomized-clinical-trial
#1
Carmen García-Gomáriz, José M Blasco, Cecili Macián-Romero, Elías Guillem-Hernández, Celedonia Igual-Camacho
OBJECTIVE: The aim of the study was to analyze the effects of endurance and high-impact training oriented toward preventing osteoporosis in postmenopausal women with calcium and vitamin D supplementation. METHODS: This study was a randomized clinical trial. Thirty-six postmenopausal women were randomized to the control and experimental groups. Thirty-four women completed the 2-year interventions. The control group training involved walking at an intense pace. The experimental group conducted high-impact training specifically oriented to prevent osteoporosis...
October 16, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29039909/indocyanine-green-holo-transferrin-nanoassemblies-for-tumor-targeted-dual-modal-imaging-and-photothermal-therapy-of-glioma
#2
Mingting Zhu, Zonghai Sheng, Yali Jia, Dehong Hu, Xin Liu, Xianyuan Xia, Chengbo Liu, Pan Wang, Xiaobing Wang, Hairong Zheng
Active-targeted cancer imaging and therapy of glioma has attracted much attention in theranostic nanomedicine. As a promising tumor-targeting ligand, holo-transferrin (holo-Tf) has been applied for enhancing delivery of nanotheranostics. However, holo-Tf-based nanoassemblies for active targeting mediated multi-modal imaging and therapeutics have not been previously reported. Here, we develop a one-step method for the preparation of holo-Tf-indocyanine green (holo-Tf-ICG) nanoassemblies for fluorescence (FL) and photoacoustic (PA) dual-modal imaging and photothermal therapy (PTT) of glioma...
October 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29035723/raloxifene-reduces-the-risk-of-local-alveolar-bone-destruction-in-a-mouse-model-of-periodontitis-combined-with-systemic-postmenopausal-osteoporosis
#3
Ryota Ichimaru, Tsukasa Tominari, Shosei Yoshinouchi, Chiho Matsumoto, Kenta Watanabe, Michiko Hirata, Yukihiro Numabe, Gillian Murphy, Hideaki Nagase, Chisato Miyaura, Masaki Inada
OBJECTIVE: Periodontitis is characterized by local inflammation leading to tooth loss and severe destruction of alveolar bone. Raloxifene is a selective estrogen receptor modulator (SERM) that halts estrogen deficiency-induced systemic bone loss in postmenopausal osteoporosis without the side effects of cancer in breast and uterus. In this study, we examined the effects of raloxifene on alveolar bone mass in a mouse model with estrogen deficiency-induced periodontitis. METHODS: Periodontitis was induced by the injection of lipopolysaccharide (LPS) into the lower gingiva in ovariectomized (OVX) mice, and the alveolar bone and femur bone mineral density (BMD) were analyzed by dual-energy X-ray absorptiometry...
September 29, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29035601/skinfold-prediction-equations-fail-to-provide-an-accurate-estimate-of-body-composition-in-elite-rugby-union-athletes-of-caucasian-and-polynesian-ethnicity
#4
Adam Zemski, Elizabeth Broad, Gary Slater
Body composition in elite rugby union athletes is routinely assessed using surface anthropometry, which can be utilised to provide estimates of absolute body composition using regression equations. This study aims to assess the ability of available skinfold equations to estimate body composition in elite rugby union athletes, who have unique physique traits and divergent ethnicity. The development of sport-specific and ethnicity-sensitive equations was also pursued. Forty-three male international Australian rugby union athletes of Caucasian and Polynesian descent underwent surface anthropometry and dual-energy X-ray absorptiometry (DEXA) assessment...
October 16, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29035553/construction-of-antithrombotic-tissue-engineered-blood-vessel-via-reduced-graphene-oxide-based-dual-enzyme-biomimetic-cascade
#5
Da Huo, Ge Liu, Yanzhao Li, Yuxin Wang, Ge Guan, Mingcan Yang, Keyu Wei, Jingyuan Yang, Lingqin Zeng, Gang Li, Wen Zeng, Chuhong Zhu
Thrombosis is one of the biggest obstacles in the clinical application of small-diameter tissue-engineered blood vessels (TEBVs). The implantation of an unmodified TEBV will lead to platelet aggregation and further activation of the coagulation cascade, in which the high concentration of adenosine diphosphate (ADP) that is released by platelets plays an important role. Inspired by the phenomenon that endothelial cells continuously generate endogenous antiplatelet substances via enzymatic reactions, we designed a reduced graphene oxide (RGO) based dual-enzyme biomimetic cascade to successively convert ADP into adenosine monophosphate (AMP) and AMP into adenosine...
October 16, 2017: ACS Nano
https://www.readbyqxmd.com/read/29033242/weight-trajectories-from-birth-and-bone-mineralization-at-7-years-of-age
#6
Teresa Monjardino, Teresa Rodrigues, Hazel Inskip, Nicholas Harvey, Cyrus Cooper, Ana Cristina Santos, Raquel Lucas
OBJECTIVE: To assess whether different trajectories of weight gain since birth influence bone mineral content (BMC) and areal bone mineral density (aBMD) at 7 years of age. STUDY DESIGN: We studied a subsample of 1889 children from the Generation XXI birth cohort who underwent whole-body dual-energy radiograph absorptiometry. Weight trajectories identified through normal mixture modeling for model-based clustering and labeled "normal weight gain," "weight gain during infancy," "weight gain during childhood," and "persistent weight gain" were used...
October 12, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29032815/effects-of-rosiglitazone-on-the-outcome-of-experimental-periapical-lesions-in-mice
#7
Katharina Morant H de Oliveira, Gustavo P Garlet, Andiara De Rossi, Driely Barreiros, Alexandra M Queiroz, Lea Assed Bezerra da Silva, Paulo Nelson-Filho, Raquel Assed Bezerra da Silva
INTRODUCTION: The purpose of this study was to evaluate a protocol for systemic administration of rosiglitazone in mice in order to stimulate apoptosis of osteocytes in the jaws and to evaluate the effect of osteocyte apoptosis induced by rosiglitazone in the progression of periapical lesions in mice at 7, 21, and 42 days. METHODS: C57BL/6 mice at 4-5 weeks of age were used. In phase 1, mice (n = 24) were treated with rosiglitazone (gavage, 10 mg/kg dose) or without (phosphate-buffered saline + 10% dimethyl sulfoxide) for 1, 2, or 3 weeks...
October 9, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29030560/risk-of-sarcopenia-and-osteoporosis-in-male-tuberculosis-survivors-korea-national-health-and-nutrition-examination-survey
#8
Chang-Jin Choi, Whan-Seok Choi, Churl-Min Kim, Sook-Young Lee, Kyung-Soo Kim
Short-term prospective studies have suggested that pulmonary tuberculosis (TB) preludes permanent loss of lean tissue and fat mass even when TB treatment is effective. The aim of this study was to estimate the risk of sarcopenia and osteoporosis among Korean male TB survivors. Data of the population-based, Korea National Health and Nutrition Examination Survey (KNHANES) (2008-2011) were analyzed, including 3,228 males aged 50 years or older who underwent chest X-ray (CXR) and dual-energy x-ray absorptiometry (DEXA)...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29028919/physical-activity-producing-low-but-not-medium-or-higher-vertical-impacts-is-inversely-related-to-bmi-in-older-adults-findings-from-a-multi-cohort-study
#9
Ahmed Elhakeem, Kimberly Hannam, Kevin C Deere, April Hartley, Emma M Clark, Charlotte Moss, Mark H Edwards, Elaine Dennison, Tim Gaysin, Diana Kuh, Andrew Wong, Cyrus Cooper, Rachel Cooper, Jon H Tobias
Background: High impact physical activity (PA) is thought to improve skeletal health but its relation to other health outcomes are unclear. We investigated associations between PA impact magnitude and body mass index (BMI) in older adults. Methods: Data were from the Cohort for Skeletal Health in Bristol and Avon (COSHIBA), Hertfordshire Cohort Study and MRC National Survey of Health and Development. Vertical accelerations peaks from seven-day hip-worn accelerometer recordings were used to classify PA as low (0...
September 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29028629/a-dual-energy-micro-ct-methodology-for-visualization-and-quantification-of-biofilm-formation-and-dentin-demineralization
#10
Paula Maciel Pires, Thais Pires Dos Santos, Andrea Fonseca-Gonçalves, Matheus Melo Pithon, Ricardo Tadeu Lopes, Aline de Almeida Neves
OBJECTIVE: The aim of this study was to induce artificial caries in human sound dentin by means of a microcosm model using human saliva as source of bacteria and to apply a novel dual-energy micro-CT technique to quantify biofilm formation and evaluate its demineralization potential. DESIGN: Eight sound third molars had the occlusal enamel removed by cutting with a diamond disk and five cylindrical cavities (±2mm diameter; ±1.5mm depth) were prepared over the dentin surface in each specimen (n=40 cavities)...
October 7, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29028534/discovery-of-benzo-g-quinazolin-benzenesulfonamide-derivatives-as-dual-egfr-her2-inhibitors
#11
Mansour S Alsaid, Abdullah A Al-Mishari, Aiten M Soliman, Fatma A Ragab, Mostafa M Ghorab
An array of some new N-(substituted)-2-((4-oxo-3-(4-sulfamoylphenyl)-3,4-dihydrobenzo[g]quinazolin-2-yl)thio)acetamide 5-19 were synthesized from the starting compound 4-(2-mercapto-4-oxobenzo[g]quinazolin-3(4H)-yl)benzenesulfonamide 4, to be assessed for their cytotoxic activity against A549 lung cancer cell line and to determine their inhibitory effect on EGFR tyrosine kinase enzyme. Compounds 5-19 showed high activity towards A549 cell line with IC50 values of 0.12-8.70 μM. Compounds 6, 12 and 18 were the most potent in this series...
September 29, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29028332/coupling-light-emitting-diodes-with-photocatalyst-coated-optical-fibers-improves-quantum-yield-of-pollutant-oxidation
#12
Li Ling, Heather Tugaoen, Jonathon Brame, Shahnawaz Sinha, Chuanhao Li, Jared J Schoepf, Kiril Hristovski, Jae-Hong Kim, Chii Shang, Paul Westerhoff
A photocatalyst-coated optical fiber was coupled with a 318-nm ultraviolet-A light emitting diode, which activated the photocatalysts by interfacial photon-electron excitation while minimizing photonic energy losses due to conventional photocatalytic barriers. The light delivery mechanism was explored via modeling of evanescent wave energy produced upon total internal reflection and photon refraction into the TiO2 surface coating. This is the first work to explore aqueous phase LED-irradiated optical fibers for treating organic pollutants and the first to propose a dual-mechanistic approach to light delivery and photocatalytic performance...
October 13, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29026195/characterization-of-fluorescein-arsenical-hairpin-flash-as-a-probe-for-single-molecule-fluorescence-spectroscopy
#13
Dennis D Fernandes, Jasbir Bamrah, Senthilkumar Kailasam, Gregory-Neal W Gomes, Yuchong Li, Hans-Joachim Wieden, Claudiu C Gradinaru
In recent years, new labelling strategies have been developed that involve the genetic insertion of small amino-acid sequences for specific attachment of small organic fluorophores. Here, we focus on the tetracysteine FCM motif (FLNCCPGCCMEP), which binds to fluorescein arsenical hairpin (FlAsH), and the ybbR motif (TVLDSLEFIASKLA) which binds fluorophores conjugated to Coenzyme A (CoA) via a phosphoryl transfer reaction. We designed a peptide containing both motifs for orthogonal labelling with FlAsH and Alexa647 (AF647)...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29024394/encapsulating-co2p-c-core-shell-nanoparticles-in-porous-carbon-sandwich-a-nitrogen-and-phosphorus-dual-doped-ph-universal-electrocatalysts-for-high-efficient-hydrogen-evolution
#14
YuanYuan Yang, XiongYi Liang, Feng Li, ShuWen Li, XinZhe Li, Siu-Pang Ng, Chi-Man Lawrence Wu, Rong Li
A new, highly-efficient and pH-universal sandwich-architecture HER electrocatalysts, constructed by 0-dimensional N and P dual-doped core-shell Co2P@C nanoparticles embedded into a 3-dimensional porous carbon sandwich (Co2P@N,P-C/CG), was synthesized by a facile two-step method of hydrothermal carbonization (HTC) and pyrolysis. Owing to the synergistic effect of N, P-codoped Co2P@C core-shell and sandwich-nanostructural substrates, it increases the interfacial electron transfer rate and the number of active sites...
October 12, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29024045/association-between-dietary-fiber-intake-and-bone-loss-in-the-framingham-offspring-study
#15
Zhaoli Dai, Yuqing Zhang, Na Lu, David T Felson, Douglas P Kiel, Shivani Sahni
Dietary fiber may increase calcium absorption, but its role in bone mineralization is unclear. Furthermore, the health effect of dietary fiber may be different between genders. We examined the association between dietary fiber (total fiber and fiber from cereal, fruits, vegetables, nuts and legumes) and bone loss at the femoral neck, trochanter and lumbar spine (L2-4) in older men and women. In the Framingham Offspring Study, at baseline (1996-2001), diet was assessed using the Willett food frequency questionnaire and bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry...
October 12, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29022182/coexistent-rheumatoid-arthritis-and-gout-a-case-series-and-review-of-the-literature
#16
Lilia Olaru, Laura Soong, Sukhvinder Dhillon, Elaine Yacyshyn
Since 1964 to present, there have been more than 33 cases of concomitant rheumatoid arthritis (RA) and gout reported in the literature. The objective of this study is to present a case series of patients with coexistent rheumatoid arthritis and gout and to provide a review of the literature. A retrospective review of a rheumatology patient database at the University of Alberta was performed (2004-2017). Patient charts were reviewed and the 1987 ARA Revised Classification Criteria for RA and 1977 ARA Classification Criteria for gout were applied to each patient...
October 12, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29020919/cell-wall-metabolism-and-hexose-allocation-contribute-to-biomass-accumulation-in-high-yielding-extreme-segregants-of-a-saccharum-interspecific-f2-population
#17
Ching Man Wai, Jisen Zhang, Tyler C Jones, Chifumi Nagai, Ray Ming
BACKGROUND: Sugarcane is an emerging dual-purpose biofuel crop for energy and sugar production, owing to its rapid growth rate, high sucrose storage in the stems, and high lignocellulosic yield. It has the highest biomass production reaching 1.9 billion tonnes in 2014 worldwide. RESULTS: To improve sugarcane biomass accumulation, we developed an interspecific cross between Saccharum officinarum 'LA Purple' and Saccharum robustum 'MOL5829'. Selected F1 individuals were self-pollinated to generate a transgressive F2 population with a wide range of biomass yield...
October 11, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29019883/bone-mineral-density-changes-of-lumbar-spine-and-femur-in-osteoporotic-patient-treated-with-bisphosphonates-and-beta-hydroxy-beta-methylbutyrate-hmb-case-report
#18
Marcin R Tatara, Witold Krupski, Barbara Majer-Dziedzic
RATIONALE: Currently available approaches to osteoporosis treatment include application of antiresorptive and anabolic agents influencing bone tissue metabolism. The aim of the study was to present bone mineral density (BMD) changes of lumbar spine in osteoporotic patient treated with bisphosphonates such as ibandronic acid and pamidronic acid, and beta-hydroxy-beta-methylbutyrate (HMB). PATIENT CONCERNS: BMD and volumetric BMD (vBMD) of lumbar spine were measured during the 6 year observation period with the use of dual-energy X-ray absorptiometry (DEXA) and quantitative computed tomography (QCT)...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29019717/adding-vfa-to-dxa-identifies-fracture-risk-in-a-way-not-duplicated-by-other-measures
#19
Jay P Ginther, Ann W Ginther, Lisa D Brodersen
OBJECTIVE: Published studies have demonstrated that adding Vertebral Fracture Assessment (VFA) to Dual-energy X-ray Absorptiometry (DXA) identifies more patients with increased fracture risk than DXA alone. But who needs VFA? This study attempts to determine if some test, other than VFA, could duplicate the additional information obtained by performing VFA on ALL first-time patients. This study looked at FRAX, Height Loss, Age, documented back pain, and Non-vertebral Fragility Fractures (FFs)...
October 11, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29019343/the-association-between-dietary-inflammatory-properties-and-bone-mineral-density-and-risk-of-fracture-in-us-adults
#20
M Mazidi, N Shivappa, M D Wirth, J R Hebert, H Vatanparast, A P Kengne
BACKGROUND/OBJECTIVES: To examine the associations of dietary inflammatory index (DII) with bone mineral density (BMD) and fracture risk in adult Americans.Subjects/Method:The United States National Health and Nutrition Examination Survey participants during 2005-2010 were included if they had measured data on dietary intake and BMD. DII scores were calculated from estimated micro- and macronutrients from a single 24-h dietary recall. BMD was measured using dual-energy X-ray absorptiometry densitometers...
October 11, 2017: European Journal of Clinical Nutrition
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