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https://www.readbyqxmd.com/read/29241277/dual-energy-computed-tomography-in-musculoskeletal-imaging-with-focus-on-fragility-fractures-of-the-pelvis
#1
Carsten Hackenbroch, Hans-Joachim Riesner, Patricia Lang, Fabian Stuby, Meinrad Beer, Benedikt Friemert, Hans-Georg Palm
Dual energy computed tomography (DECT) is a constantly evolving technology, which opens up new diagnostic possibilities. It is particularly valuable for musculoskeletal (MSK) imaging. Due to the lack of recognition and availability of dual energy scanners, routine use is only established in a few centres. The intention of this review is to show the possibilities and fields of applications of the DECT in MSK imaging, as well as to describe technical principles and typical indications. We mainly focus on the use of DECT in the context of fragility fractures of the pelvis...
December 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29240995/mono-chromophoric-design-strategy-for-tetrazine-based-colorful-bioorthogonal-probes-with-a-single-fluorescent-core-skeleton
#2
Youngjun Lee, Wansang Cho, June Sung, Eunha Kim, Seung Bum Park
Fluorogenic bioorthogonal probe is ideal for fluorescent imaging in live cell condition. By taking advantage of dual functionality of tetrazine (Tz), bioorthogonal reaction unit as well as fluorescence quencher, fluorophore-Tz conjugate (FLTz) has been utilized for fluorescent live cell imaging via inverse electron-demand Diels-Alder (iEDDA) type bioorthogonal reaction. However, most of FLTz strategies rely on donor-acceptor type energy transfer mechanism which limits red-shifting of probes' emission wavelength without deterioration of fluorescent turn-on/off ratio...
December 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29240982/multi-dimensional-bone-density-phenotyping-reveals-new-insights-in-to-genetic-regulation-of-the-pediatric-skeleton
#3
Jonathan A Mitchell, Alessandra Chesi, Diana L Cousminer, Shana E McCormack, Heidi J Kalkwarf, Joan M Lappe, Vicente Gilsanz, Sharon E Oberfield, John A Shepherd, Andrea Kelly, Babette S Zemel, Struan F A Grant
Osteoporosis is a complex disease with developmental origins. It is therefore important to understand the genetic contribution to pediatric areal bone mineral density (aBMD). Individual skeletal site phenotyping has been primarily used to identify pediatric aBMD loci. However, this approach is limited because there is a degree of aBMD discordance across skeletal sites. We, therefore, applied a novel multi-dimensional phenotyping approach to further understand the genetic regulation of pediatric aBMD. Our sample comprised a prospective, longitudinal cohort of 1,293 children of European ancestry (52% female; up to 7 annual measurements)...
December 14, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29240803/bone-edema-on-magnetic-resonance-imaging-is-highly-associated-with-low-bone-mineral-density-in-patients-with-ankylosing-spondylitis
#4
Danmin Wang, Zhiduo Hou, Yao Gong, Subiao Chen, Ling Lin, Zhengyu Xiao
OBJECTIVE: This study aimed to assess the relationship between bone marrow edema (BME) on magnetic resonance imaging (MRI) and bone mineral density (BMD) in patients with ankylosing spondylitis (AS). METHODS: The study included 333 patients with AS who underwent BMD measurements and axial MRI. Additionally, 106 normal controls were included. The modified New York criteria were used as the classification criteria of AS. Clinical, laboratory, and imaging data were collected and analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/29240265/bone-mineral-density-and-its-serial-changes-are-associated-with-pth-levels-in-pseudohypoparathyroidism-type-1b-patients
#5
Xueying Chu, Yan Zhu, Ou Wang, Min Nie, Tingting Quan, Yu Xue, Wenbo Wang, Yan Jiang, Mei Li, Weibo Xia, Xiaoping Xing
BACKGROUND: Bone responsiveness to serum PTH in pseudohypoparathyroidism 1B (PHP1B) is controversial. OBJECTIVE: Forty-eight PHP1B patients diagnosed by molecular analysis were recruited from 2000 to 2016 from the Peking Union Medical College Hospital. Fifty-five gender-matched non-surgical hypoparathyroidism (NS-HP) patients were selected and included for comparison. METHODS: Basic information, laboratory test and dual-energy X-ray absorptiometry results were collected...
December 14, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29240176/highly-efficient-optical-parametric-amplifier-tunable-from-near-to-mid-ir-for-driving-extreme-nonlinear-optics-in-solids
#6
E A Migal, F V Potemkin, V M Gordienko
We have developed a robust optical parametric amplifier (OPA) based on three-AgGaS2-crystal pumping by a Cr:Forsterite GW femtosecond laser system, generating 150 fs pulses in dual bands of 1.6-2.0 μm (signal wave) and 3.5-5.5 μm (idler wave). By introducing a negative prechirp to the pump, a combined efficiency in two waves of greater than 10% was achieved, with signal energy up to 110 μJ and idler energy up to 43 μJ. Operation parameters of the system (intensity up to 90  TW/cm2) make OPA a promising tool for driving nonlinear optical phenomena, including generation of optical harmonics and laser-induced extreme states of matter in solids and liquids...
December 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29239893/switch-from-tenofovir-disoproxil-fumarate-combination-to-dolutegravir-plus-rilpivirine-improves-parameters-of-bone-health
#7
Grace A Mccomsey, Sergio Lupo, David Parks, Mónica Coronado Poggio, Joseph De Wet, Lesley P Kahl, Kostas Angelis, Brian Wynne, Kati Vandermeulen, Martin Gartland, Michael Cupo, Michael Aboud
OBJECTIVE: Bone mineral density (BMD) loss, a risk factor for osteoporosis, has been attributed to HIV infection and antiretroviral therapy (ART), including regimens containing tenofovir disoproxil fumarate. DESIGN: Study 202094 is an open-label, parallel-group, sub-study of the phase III SWORD-1 and SWORD-2 studies (ClincialTrials.gov identifier, NCT02478632). METHODS: HIV-1-infected adults with HIV-1 RNA < 50 copies per mL who received ART containing tenofovir disoproxil fumarate for ≥6 months were randomized to receive dolutegravir+rilpivirine or continue current ART regimen...
December 12, 2017: AIDS
https://www.readbyqxmd.com/read/29239855/experimental-verification-of-stopping-power-prediction-from-single-and-dual-energy-computed-tomography-in-biological-tissues
#8
Christian Möhler, Tom Russ, Patrick Wohlfahrt, Alina Elter, Armin Runz, Christian Richter, Steffen Greilich
An experimental setup for consecutive measurement of ion and x-ray absorption in tissue or other materials is introduced. With this setup using a 3D-printed sample container, the reference stopping-power ratio (SPR) of materials can be measured with an uncertainty of below 0.1%. A total of 65 porcine and bovine tissue samples were prepared for measurement, comprising five samples each of 13 tissue types representing about 80% of the total body mass (three different muscle and fatty tissues, liver, kidney, brain, heart, blood, lung and bone)...
December 14, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29239351/association-of-serum-uric-acid-levels-with-osteoporosis-and-bone-turnover-markers-in-a-chinese-population
#9
Dan-Dan Yan, Jie Wang, Xu-Hong Hou, Yu-Qian Bao, Zhen-Lin Zhang, Cheng Hu, Wei-Ping Jia
Recent evidence shows that uric acid is protective against some neurological diseases, but can be detrimental in many metabolic and cardiovascular disorders. In this study, we examined the association between serum uric acid levels and bone metabolism in Chinese males and postmenopausal females. A total of 943 males and 4256 postmenopausal females were recruited in Shanghai. The levels of serum uric acid and bone turnover markers (BTMs) were detected along with other biochemical traits. In addition, the fat distribution was calculated through MRI and image analysis software, and bone mineral density (BMD) was determined using dual-energy X-ray absorptiometry...
December 14, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29239129/association-of-prenatal-exposure-to-gestational-diabetes-with-offspring-body-composition-and-regional-body-fat-distribution
#10
M Kearney, J Perron, I Marc, S J Weisnagel, A Tchernof, J Robitaille
The aim of this cohort study was to compare body composition and regional body fat distribution between children exposed (GDM+) or unexposed (GDM-) in utero to gestational diabetes mellitus (GDM) and to investigate the association with the glycaemic and the insulin profile. Data from 56 GDM+ and 30 GDM- were analysed. Height, weight and waist circumference were measured. Total and regional body composition was measured by dual-energy X-ray absorptiometry. Insulin, glucose and HbA1c were obtained from a fasting plasma sample, and the HOMA-IR index was calculated...
December 13, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/29237954/assessment-of-the-scatter-correction-procedures-in-single-photon-emission-computed-tomography-imaging-using-simulation-and-clinical-study
#11
Mehravar Rafati, Hemmatollah Rouhani, Ahmad Bitarafan-Rajabi, Mahsa Noori-Asl, Bagher Farhood, Hadi Taleshi Ahangari
BACKGROUND: Compton-scattered photons transfer incorrect spatial information. These photons are detected in used photo-peak energy window. In this study, three scatter correction procedures including dual-energy window (DEW), three energy window (TEW), and new approach were evaluated, and then the best procedure based on simulation and clinical conditions introduced. MATERIALS AND METHODS: In this study, simulation projections and three-dimensional nonuniform rational B-spline-based Cardiac-Torso phantoms were produced by GEANT4 application for emission tomography simulation code...
October 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29237264/dual-ratiometric-target-triggered-fluorescent-probe-for-simultaneous-quantitative-visualization-of-tumor-microenvironment-protease-activity-and-ph-in-vivo
#12
Tiancong Ma, Yi Hou, Jianfeng Zeng, Chunyan Liu, Peisen Zhang, Lihong Jing, Dihua Shangguan, Mingyuan Gao
The abnormal expression of tumor-associated proteases and lowered extracellular pH are important signatures strongly associated with cancer invasion, progression, and metastasis. However, their malignant effects were mainly identified using cell and tissue studies. To non-invasively visualize the heterogeneous distribution of these abnormal indicators in vivo and further disclose their collective behaviors, a target-triggered fluorescent nanoprobe composed of a ratiometric pH-sensitive dye, a near infrared dye (Cy5...
December 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29234698/data-on-heavy-metal-and-magnetic-relationships-in-coastal-sediments-from-south-east-coast-of-tamilnadu-india
#13
R Ravisankar, N Harikrishnan, A Chandrasekaran, M Suresh Gandhi, R Alagarsamy
In this data, the heavy metal concentration and magnetic susceptibility in coastal sediment samples collected from Periyakalapet to Parangaipettai of East Coast of Tamilnadu using Energy Dispersive X-ray Fluorescence (EDXRF) technique and dual frequency susceptibility meter. We aimed to (i) determine the heavy metal concentration in the sediments from Periyakalapet to Parangaipettai of East Coast of Tamilnadu (ii) assess the magnetic mineral property of sediments (iii) study the correlation between heavy metal and magnetic susceptibility...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29234560/collegiate-male-soccer-players-exhibit-between-limb-symmetry-in-body-composition-muscle-strength-and-range-of-motion
#14
Matthew D DeLang, Melodie Kondratek, Lorenzo J DiPace, Tamara Hew-Butler
Background: Functional and structural asymmetries attributed to limb dominance are equivocal in soccer players. Previous authors hypothesize the existence of between-limb asymmetry secondary to the repetitive unilateral nature of kicking. However, symmetry is often present, particularly in measures of muscle strength. Purpose: The purpose of the present study was to determine if lateral dominance is accompanied by corresponding between-limb asymmetries in a comprehensive assessment of body composition, muscle strength, and range of motion in healthy soccer players...
December 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/29234125/comparison-between-dual-energy-x-ray-absorptiometry-and-skinfold-thickness-in-assessing-body-fat-in-overweigh-obese-adult-patients-with-type-2-diabetes
#15
Elisabetta Bacchi, Valentina Cavedon, Carlo Zancanaro, Paolo Moghetti, Chiara Milanese
Percentage of body fat (%BF) is estimated in clinical practice using anthropometric equations, but little is known about their reliability in overweight/obese patients with type-2 diabetes. The aim of this study was to compare, in overweight/obese adults with type-2 diabetes, %BF estimated with several commonly used anthropometric equations and %BF measured with dual-energy X-ray absorptiometry (DXA, Hologic). The %BF was measured with DXA in 40 patients aged 40-68 years with type-2 diabetes (mean HbA1c, 7...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29234051/lagrangian-statistics-and-intermittency-in-gulf-of-mexico
#16
Liru Lin, Wei Zhuang, Yongxiang Huang
Due to the nonlinear interaction between different flow patterns, for instance, ocean current, meso-scale eddies, waves, etc, the movement of ocean is extremely complex, where a multiscale statistics is then relevant. In this work, a high time-resolution velocity with a time step 15 minutes obtained by the Lagrangian drifter deployed in the Gulf of Mexico (GoM) from July 2012 to October 2012 is considered. The measured Lagrangian velocity correlation function shows a strong daily cycle due to the diurnal tidal cycle...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29234002/dual-energy-micro-ct-for-quantifying-the-time-course-and-staining-characteristics-of-ex-vivo-animal-organs-treated-with-iodine-and-gadolinium-based-contrast-agents
#17
Juliana Martins de Souza E Silva, Julian Utsch, Melanie A Kimm, Sebastian Allner, Michael F Epple, Klaus Achterhold, Franz Pfeiffer
Chemical staining of soft-tissues can be used as a strategy to increase their low inherent contrast in X-ray absorption micro-computed tomography (micro-CT), allowing to obtain fast three-dimensional structural information of animal organs. Though some staining agents are commonly used in this context, little is known about the staining agents' ability to stain specific types of tissues; the times necessary to provide a sufficient contrast; and the effect of staining solution in distorting the tissue. Here we contribute to studies of animal organs (mouse heart and lungs) using staining combined with dual-energy micro-CT (DECT)...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233845/physiologic-mitochondrial-fragmentation-is-a-normal-cardiac-adaptation-to-increased-energy-demand
#18
Michael Coronado, Giovanni Fajardo, Kim Nguyen, Mingming Zhao, Kristina B Kooiker, Gwanghyun Jung, Dong-Qing Hu, Sushma Reddy, Erik Sandoval, Aleksandr Stotland, Roberta A Gottlieb, Daniel Bernstein
Rationale: Mitochondria play a dual role in the heart, responsible for meeting energetic demands and regulating cell death. Paradigms have held that mitochondrial fission and fragmentation are the result of pathologic stresses such as ischemia, are an indicator of poor mitochondrial health, and lead to mitophagy and cell death. However, recent studies demonstrate that inhibiting fission also results in decreased mitochondrial function and cardiac impairment, suggesting that fission is important for maintaining cardiac and mitochondrial bioenergetic homeostasis...
December 12, 2017: Circulation Research
https://www.readbyqxmd.com/read/29233667/knee-confidence-in-youth-and-young-adults-at-risk-of-post-traumatic-osteoarthritis-3-10-years-following-intra-articular-knee-injury
#19
A M Ezzat, J L Whittaker, C Toomey, P K Doyle-Baker, M Brussoni, C A Emery
OBJECTIVES: To examine differences in knee confidence between individuals with a history of youth sport-related knee injury and uninjured controls. DESIGN: Historical cohort study. METHODS: Participants include 100 individuals who sustained a youth sport-related intra-articular knee injury 3-10 years previously and 100 age-, sex- and sport-matched uninjured controls. Outcomes included: Knee confidence (Knee Osteoarthritis and Outcome Score); fat mass index (FMI; dual-energy X-ray absorptiometry); and weekly physical activity (modified Godin-Shephard Leisure Time Questionnaire)...
November 26, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29232481/tracking-of-areal-bone-mineral-density-from-age-eight-to-young-adulthood-and-factors-associated-with-deviation-from-tracking-a-17-yr-prospective-cohort-study
#20
Yi Yang, Feitong Wu, Tania Winzenberg, Graeme Jones
We have previously shown that bone mineral density (BMD) tracks strongly from age 8 to 16. This study aimed to describe whether this strong tracking continued to age 25 and describe factors associated with deviation from tracking. Ninety-nine participants were followed from age 8 to 25 and 197 participants from age 16 to 25. Outcomes measured were BMD at the spine, hip and total body (by dual-energy X-ray absorptiometry (DXA)). Other factors measured were anthropometrics, inhaled corticosteroids (ICS) use, history of being breastfed, sports participation, fitness (by physical work capacity (PWC170 )), lean mass (LM) and fat mass (FM) (by DXA)...
December 12, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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