keyword
MENU ▼
Read by QxMD icon Read
search

maternal-fetal interface

keyword
https://www.readbyqxmd.com/read/27905000/decidual-natural-killer-cells-and-the-immune-microenvironment-at-the-maternal-fetal-interface
#1
REVIEW
Binqing Fu, Haiming Wei
During early pregnancy, an orchestrated evolutionary maternal adaption toward tolerance of the semiallogeneic fetus is required to ensure decidualization and early embryo development. Remodeling of the immune system involves natural killer cells (NKs), macrophages, T cells and dendritic cells (DCs) altering the microenvironment in the deciduas. In particular, a unique population of NK cells with a CD56(bright)CD16(-) phenotype in the decidua has been proposed to play a key role in the maternal adaptation to pregnancy...
November 29, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27903743/uric-acid-crystals-induce-placental-inflammation-and-alter-trophoblast-function-via-an-il-1-dependent-pathway-implications-for-fetal-growth-restriction
#2
Marie-Eve Brien, Cyntia Duval, Julia Palacios, Ines Boufaied, Andrée-Anne Hudon-Thibeault, Mathieu Nadeau-Vallée, Cathy Vaillancourt, Colin P Sibley, Vikki M Abrahams, Rebecca L Jones, Sylvie Girard
Excessive placental inflammation is associated with several pathological conditions, including stillbirth and fetal growth restriction. Although infection is a known cause of inflammation, a significant proportion of pregnancies have evidence of inflammation without any detectable infection. Inflammation can also be triggered by endogenous mediators, called damage associated molecular patterns or alarmins. One of these damage-associated molecular patterns, uric acid, is increased in the maternal circulation in pathological pregnancies and is a known agonist of the Nlrp3 inflammasome and inducer of inflammation...
November 30, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27898863/rapid-communication-expression-of-an-endogenous-retroviral-element-during-early-gestation-in-beef-heifers
#3
K J McLean, M S Crouse, M R Crosswhite, D N Black, C R Dahlen, P P Borowicz, L P Reynolds, A K Ward, B W Neville, J S Caton
Endogenous retroviral gene elements have been implicated in development and formation of the feto-maternal interface. A variant of the syncytin endogenous retroviral envelope gene family, , was recently found in ruminants. We hypothesized that mRNA would be differentially expressed in utero-placental tissues and would fluctuate during key time points of early gestation in beef heifers. Commercial Angus crossbred heifers ( = 46; ∼15 mo of age; BW = 362.3 ± 34.7kg) housed in 6-animal pens were fed daily with native grass hay and supplemented with cracked corn to gain 0...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27891347/decidual-cd56-natural-killer-cells-in-spontaneous-early-pregnancy-loss-an-immunohistochemical-study
#4
Balamurugan Senthilnayagam, Sridhar Karthikeyan, Jayapriya Sukumaran, Anoop Srivalsan, Ramesh Rao, Vasantha Subbiah
INTRODUCTION: Natural killer cells are believed to promote placental and trophoblastic growth and provide immune- modulation at maternal-fetal interface in pregnancy and their role in reproductive failure has been a matter of discussion. AIM: To study CD56+ Natural killer cells in spontaneous pregnancy loss. MATERIALS AND METHODS: In this prospective observational study, formalin-fixed paraffin embedded sections from products of conception from twenty women each with spontaneous early pregnancy loss (test group) and elective pregnancy termination (control group)...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27829441/characterization-of-exosomal-release-in-bovine-endometrial-intercaruncular-stromal-cells
#5
Yong Qin Koh, Hassendrini N Peiris, Kanchan Vaswani, Sarah Reed, Gregory E Rice, Carlos Salomon, Murray D Mitchell
BACKGROUND: Cell-to-cell communication between the blastocyst and endometrium is critical for implantation. In recent years, evidence has emerged from studies in humans and several other animal species that exosomes are secreted from the endometrium and trophoblast cells and may play an important role in cell-to-cell communication maternal-fetal interface during early pregnancy. Exosomes are stable extracellular lipid bilayer vesicles that encapsulate proteins, miRNAs, and mRNAs, with the ability to deliver their cargo to near and distant sites, altering cellular function(s)...
November 9, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27827548/is-preterm-labor-influenced-by-the-maternal-fetal-interface
#6
Ana Luísa Areia, Pedro Rodrigues, Ana Alarcão, Ana Ladeirinha, Paulo Moura, Lina Carvalho
Preterm labor (PTL) accounts for almost 11% of deliveries, and is a major cause of neonatal morbidity and mortality. T regulatory (Treg) cells may prevent fetal rejection by the maternal immune system under the influence of progesterone. Case control study was conducted to determine Treg cells, IL-10, TGF-β, and membrane progesterone receptorα (mPRα) in the maternal-fetal interface (placenta), including eight pregnant women with threatened PTL (study group) and 16 normal-delivery women (control group). Comparing study group versus control, mean gestational age of delivery differed significantly (p = 0...
November 9, 2016: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/27819683/neutralizing-human-antibodies-prevent-zika-virus-replication-and-fetal-disease-in-mice
#7
Gopal Sapparapu, Estefania Fernandez, Nurgun Kose, Bin Cao, Julie M Fox, Robin G Bombardi, Haiyan Zhao, Christopher A Nelson, Aubrey L Bryan, Trevor Barnes, Edgar Davidson, Indira U Mysorekar, Daved H Fremont, Benjamin J Doranz, Michael S Diamond, James E Crowe
Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that can cause severe disease, including congenital birth defects during pregnancy(1). To develop candidate therapeutic agents against ZIKV, we isolated a panel of human monoclonal antibodies (mAbs) from subjects with prior ZIKV infection. A subset of mAbs recognized diverse epitopes on the envelope (E) protein and exhibited potently neutralizing activity. One of the most inhibitory mAbs, ZIKV-117, broadly neutralized infection of ZIKV strains corresponding to African, Asian, and American lineages...
November 7, 2016: Nature
https://www.readbyqxmd.com/read/27793374/decreased-toll-like-receptor-2-messenger-ribonucleic-acid-and-increased-toll-like-receptor-4-in-the-tubal-epithelium-next-to-the-infiltrated-trophoblasts-during-tubal-pregnancy
#8
Yin Fen Ji, Jian Xu, Tao Zhang, Li You Chen
OBJECTIVE: To explore the expression patterns of Toll-like receptor (TLR)2 and TLR4 in the tubal epithelial cells next to the infiltrated trophoblasts at the maternal-fetal interface during tubal pregnancy. DESIGN: Prospective, observational study. SETTING: University-based obstetrics and gynecology hospital. PATIENT(S): Thirty-seven women undergoing salpingectomy for tubal ampullary pregnancy and nine nonpregnant patients with benign uterine or appendix disease...
October 25, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27792886/tim-3-expression-on-immune-cells-and-roles-at-the-maternal-fetal-interface
#9
REVIEW
Xiao-Hui Hu, Mao-Xing Tang, Gil Mor, Ai-Hua Liao
Successful pregnancy relies on the accurate regulation of the maternal-fetal immune system. Without enough tolerance in the uterine microenvironment, the mother and the hemiallogeneic fetus could not peacefully coexist. T cell immunoglobulin and mucin domain (Tim)-3 is a molecule originally regarded as to be expressed on terminally differentiated IFN-γ expressing CD4(+) T cells (Th1). The engagement of Tim-3 with its ligand, galectin-9 (Gal-9) could induce the exhaustion or apoptosis of effector T cells, and thus might regulate the tolerance...
October 20, 2016: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/27780542/macrophage-polarisation-affects-their-regulation-of-trophoblast-behaviour
#10
R J Buckley, G S Whitley, I E Dumitriu, J E Cartwright
INTRODUCTION: During the first trimester of human pregnancy, fetally-derived extravillous trophoblast (EVT) invade into the uterine decidua and remodel the uterine spiral arteries to ensure that sufficient blood reaches the maternal-fetal interface. Decidual macrophages have been implicated in the regulation of decidual remodelling, and aberrant activation of these immune cells is associated with pre-eclampsia. METHODS: The monocytic cell line THP-1 was activated to induce a classically- or alternatively-activated macrophage phenotype and the conditioned media was used to treat the EVT cell line SGHPL-4 in order to determine the effect of macrophage polarisation on trophoblast behaviour in-vitro...
November 2016: Placenta
https://www.readbyqxmd.com/read/27780537/bone-mesenchymal-stem-cells-improve-pregnancy-outcome-by-inducing-maternal-tolerance-to-the-allogeneic-fetus-in-abortion-prone-matings-in-mouse
#11
Yu-Han Meng, Xiao-Hui Zhu, Li-Ying Yan, Yan Zhang, Hong-Yan Jin, Xi Xia, Rong Li, Jie Qiao
INTRODUCTION: The successful pregnancy depends on maternal immune tolerance against the fetus. It has been reported that MSCs (mesenchymal stem cells) could play a regulatory role on immune cells such as CD4(+)T cells, macrophages and NK cells, but their effect on recurrent miscarriage is unknown. STUDY DESIGN: In a prospective study, the abortion-prone (CBA/J × DBA/2) H-2(d) × H-2(k) mice were utilized. Female CBA/J mice (8-10 weeks old) were injected with vehicle or MSCs via tail vein or uterine horns, and 14 days later, they were mated with DBA/2 males for the following experiments...
November 2016: Placenta
https://www.readbyqxmd.com/read/27759009/zika-virus-reveals-broad-tissue-and-cell-tropism-during-the-first-trimester-of-pregnancy
#12
Hicham El Costa, Jordi Gouilly, Jean-Michel Mansuy, Qian Chen, Claude Levy, Géraldine Cartron, Francisco Veas, Reem Al-Daccak, Jacques Izopet, Nabila Jabrane-Ferrat
The outbreak of the Zika Virus (ZIKV) and its association with fetal abnormalities have raised worldwide concern. However, the cellular tropism and the mechanisms of ZIKV transmission to the fetus during early pregnancy are still largely unknown. Therefore, we ex vivo modeled the ZIKV transmission at the maternal-fetal interface using organ culture from first trimester pregnancy samples. Here, we provide evidence that ZIKV strain circulating in Brazil infects and damages tissue architecture of the maternal decidua basalis, the fetal placenta and umbilical cord...
October 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27745831/an-ancient-fecundability-associated-polymorphism-switches-a-repressor-into-an-enhancer-of-endometrial-tap2-expression
#13
Katelyn M Mika, Vincent J Lynch
Variation in female reproductive traits, such as fertility, fecundity, and fecundability, is heritable in humans, but identifying and functionally characterizing genetic variants associated with these traits has been challenging. Here, we explore the functional significance and evolutionary history of a T/C polymorphism of SNP rs2071473, which we have previously shown is an eQTL for TAP2 and significantly associated with fecundability (time to pregnancy). We replicated the association between the rs2071473 genotype and TAP2 expression by using GTEx data and demonstrated that TAP2 is expressed by decidual stromal cells at the maternal-fetal interface...
November 3, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27736782/inlp-a-new-virulence-factor-with-strong-placental-tropism
#14
Cristina Faralla, Gabrielle A Rizzuto, David E Lowe, Byoungkwan Kim, Cara Cooke, Lawrence R Shiow, Anna I Bakardjiev
Intrauterine infection is a major detriment for maternal-child health and occurs despite local mechanisms that protect the maternal-fetal interface from a wide variety of pathogens. The bacterial pathogen Listeria monocytogenes causes spontaneous abortion, stillbirth, and preterm labor in humans, and serves as a model for placental pathogenesis. Given the unique immunological environment of the maternal-fetal interface we hypothesized that virulence determinants with placental tropism are required for infection of this tissue...
October 10, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27733657/establishment-of-the-human-uteroplacental-circulation-a-historical-perspective
#15
Kenna Degner, Ronald R Magness, Dinesh M Shah
The uterine vasculature undergoes marked changes during pregnancy in order to provide the necessary increase in blood flow to support growth and nutrition of the uterus, placenta, and developing fetus. Pregnancy-associated uterine vascular transformations are orchestrated by a complex array of endocrine and cellular mechanisms to bring about structural modifications at the maternal-fetal interface, which collectively lead to development of the uteroplacental circulation. Understanding intrinsic uterine vascular remodeling in pregnancy is essential for understanding the physiologic and pathophysiologic regulation of maternal uterine blood flow...
October 12, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27707956/dynamics-of-base-excision-repair-at-the-maternal-fetal-interface-in-pregnancies-complicated-by-preeclampsia
#16
Serkalem Tadesse, Nicholas G Norwitz, Seth Guller, Felice Arcuri, Paolo Toti, Errol R Norwitz, Dawit Kidane
Preeclampsia (PE) (gestational proteinuric hypertension) is the leading cause of maternal and perinatal mortality worldwide. Although placental endothelial dysfunction and oxidative stress are known to contribute to PE, the exact pathological basis for this disorder remains unclear. Previously, we demonstrated that DNA damage at the maternal-fetal interface is more common in the placentas of women with PE than normotensive controls. In this study, we utilized an in vivo comparative study, including 20 preeclamptic women and 8 healthy control subjects, and an in vitro hypoxia/reperfusion model to mimic the effects of oxidative stress at the maternal-fetal interface...
October 5, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27697223/compartmentalized-localization-of-11%C3%AE-hsd-1-and-2-at-the-feto-maternal-interface-in-the-first-trimester-of-human-pregnancy
#17
Qianlan Yang, Wangsheng Wang, Chao Liu, Yu Wang, Kang Sun
Glucocorticoids are engaged in a number of actions at the feto-maternal interface for the establishment of early pregnancy. However, excessive glucocorticoids can be deleterious to fetal development. Therefore, compartmentalized distribution of 11β-hydroxysteroid dehydrogenase 1 and 2 (11β-HSD1 and 2), which regenerates and inactivates cortisol respectively, would ensure an optimal cortisol concentration at the feto-maternal interface for the establishment of early gestation. However, the distribution pattern of 11β-HSD1 and 2 at the feto-maternal interface in early human pregnancy is not clearly defined...
October 2016: Placenta
https://www.readbyqxmd.com/read/27696611/prdm1-blimp1-is-widely-distributed-to-the-nascent-fetal-placental-interface-in-the-mouse-gastrula
#18
Maria M Mikedis, Karen M Downs
BACKGROUND: PRDM1 is a transcriptional repressor that contributes to primordial germ cell (PGC) development. During early gastrulation, epiblast-derived PRDM1 is thought to be restricted to a lineage-segregated germ line in the allantois. However, given recent findings that PGCs overlap an allantoic progenitor pool that contributes widely to the fetal-umbilical interface, posterior PRDM1 may also contribute to soma. RESULTS: Within the posterior mouse gastrula (early streak, 12-s stages, embryonic days ∼6...
October 3, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27661402/placental-implantation-abnormalities-a-modern-approach
#19
Sevan A Vahanian, Anthony M Vintzileos
PURPOSE OF REVIEW: Placental implantation abnormalities (PIAs) comprise a large group of disorders associated with significant maternal, fetal, and neonatal morbidity. RECENT FINDINGS: Risk factors include prior uterine surgery/myometrial scarring and the presence of placenta previa with or without prior cesarean delivery. Newly identified risk factors include previous prelabor cesarean delivery and previous postpartum hemorrhage. PIAs contribute substantially to preterm birth with prematurity rates ranging from 38 to 82%...
December 2016: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27652273/recent-advances-in-our-understanding-of-hla-g-biology-lessons-from-a-wide-spectrum-of-human-diseases
#20
REVIEW
Fabio Morandi, Roberta Rizzo, Enrico Fainardi, Nathalie Rouas-Freiss, Vito Pistoia
HLA-G is a HLA-class Ib molecule with potent immunomodulatory activities, which is expressed in physiological conditions, where modulation of the immune response is required to avoid allograft recognition (i.e., maternal-fetal interface or transplanted patients). However, HLA-G can be expressed de novo at high levels in several pathological conditions, including solid and hematological tumors and during microbial or viral infections, leading to the impairment of the immune response against tumor cells or pathogens, respectively...
2016: Journal of Immunology Research
keyword
keyword
102507
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"