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maternal-fetal interface

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https://www.readbyqxmd.com/read/29756666/abnormal-lymphatic-vessel-development-is-associated-with-decreased-decidual-regulatory-t-cells-in-severe-preeclampsia
#1
Yun Ji Jung, Yejin Park, Hyun-Soo Kim, Hwa Jin Lee, Yoo-Na Kim, JoonHo Lee, Young-Han Kim, Yong-Sun Maeng, Ja-Young Kwon
PROBLEM: The lymphatic vasculature controls leukocytes trafficking and limits the adaptive immune response. In previous models of preeclampsia (PE), defective immune function caused by disruption of lymphangiogenesis was shown to be involved in the disease pathophysiology. Especially, the dysfunction of regulatory T cells (Treg) at the maternal-fetal interface may be one of the causes of severe PE. In particular, activation of Tregs to obtain immune tolerance requires adequate antigen presentation through the lymphatic system...
May 14, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29735482/cd71-erythroid-suppressor-cells-promote-fetomaternal-tolerance-through-arginase-2-and-pdl-1
#2
Cole Delyea, Najmeh Bozorgmehr, Petya Koleva, Garett Dunsmore, Shima Shahbaz, Vivian Huang, Shokrollah Elahi
Survival of the allogeneic pregnancy depends on the maintenance of immune tolerance to paternal alloantigens at the fetomaternal interface. Multiple localized mechanisms contribute to the fetal evasion from the mother's immune rejection as the fetus is exposed to a wide range of stimulatory substances such as maternal alloantigens, microbes and amniotic fluids. In this article, we demonstrate that CD71+ erythroid cells are expanded at the fetomaternal interface and in the periphery during pregnancy in both humans and mice...
May 7, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29723118/protective-effects-of-interferon-tau-against-lipopolysaccharide-induced-embryo-implantation-failure-in-pregnant-mice
#3
Kangfeng Jiang, Jing Yang, Yu Chen, Shuai Guo, Gan Zhao, Haichong Wu, Ganzhen Deng
Interferon-tau (IFN-τ), a novel type I interferon, is produced by trophoblast cells in ruminants. Previous studies have confirmed that IFN-τ could induce immunological tolerance in humans and other species. However, there are few reports on whether IFN-τ has a protective effect on embryo implantation failure caused by excessive inflammation at the maternal-fetal interface. In our study, a mouse model of lipopolysaccharide (LPS)-induced implantation failure was successfully established, and we investigated the protective effects of IFN-τ...
May 3, 2018: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29713810/the-role-of-interleukin-10-in-the-pathophysiology-of-preeclampsia
#4
REVIEW
Hajrunisa Cubro, Sonu Kashyap, Meryl C Nath, Allan W Ackerman, Vesna D Garovic
PURPOSE OF REVIEW: The pathophysiology of preeclampsia is complex and not entirely understood. A key feature in preeclampsia development is an immunological imbalance that shifts the maternal immune response from one of tolerance towards one promoting chronic inflammation and endothelial dysfunction. As a key regulator of immunity, IL-10 not only has immunomodulatory activity, but also directly benefits vasculature and promotes successful cellular interactions at the maternal-fetal interface...
April 30, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29703848/should-empiric-antibiotic-therapy-be-withheld-when-aetiology-of-preterm-birth-is-non-infectious-a-protocol-for-a-systematic-review
#5
Joanna Seliga-Siwecka, Mohammed Toseef Ansari, Judy Aschner, Margaret Sampson, Justyna Romańska
INTRODUCTION: Preterm birth (PTB) at <37 weeks of gestation is the leading cause of perinatal morbidity and mortality in developed countries. The traditional approach has been based on the assumption that PTB is primarily a result of intrauterine infection, which triggers preterm labour and puts the newborn at risk of early onset sepsis (EOS). We are currently experiencing a rise in prematurity that results from maternal and fetal diseases unrelated to infection. We have designed a systematic review to assess whether chemoprophylaxis should be withheld when the aetiology of preterm birth is non-infectious...
April 27, 2018: BMJ Open
https://www.readbyqxmd.com/read/29700097/prostaglandin-e2-receptor-3-ep3-signaling-is-induced-in-placentas-with-unexplained-recurrent-pregnancy-losses-urpl
#6
Yao Ye, Aurelia Vattai, Nina Ditsch, Christina Kuhn, Martina Rahmeh, Sven Mahner, Myriam Ripphahn, Roland Immler, Markus Sperandio, Udo Jeschke, Viktoria von Schoenfeldt
Although an inflammatory microenvironment is required for successful implantation, an inflammatory overreaction is one of the causes of unexplained recurrent pregnancy losses (uRPL). Prostaglandin E2 (PGE2) plays a pivotal role in regulating immune balance during early pregnancy and it can stimulate inflammatory reactions via EP3. However, the role of PGE2 receptor signaling in the uRPL remains unknown. We aimed to investigate whether prostaglandin E2 receptor 3 (EP3) signaling is involved in the mechanism of uRPL...
April 26, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29693486/serum-galectin-7-is-not-useful-to-predict-abortion-in-the-first-trimester
#7
Fulya Cagli, Gulsum Uysal, Leyla Oz, Hatice Akkaya, Huseyin Aksoy, Eda Ulku Karakilic, Gokhan Acmaz
OBJECTIVE: Galectins are animal lectins that bind to surface glycoproteins expressed at the fetal-maternal interface. The aim of this prospective case-control study was to investigate the possible relationship between levels of maternal serum galectin-7 and threatened abortion (TA) and to determine whether serum galectin-7 had any prognostic value. METHODS: This prospective study was conducted between August 2014 and February 2015. Included in the study were 31 consecutive pregnant women who were hospitalized for TA between 6 and 14 weeks of gestation and 33 healthy gestational age matched pregnant women without any symptoms of miscarriage...
April 25, 2018: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/29679053/pregnancy-associated-diamine-oxidase-originates-from-extravillous-trophoblasts-and-is-decreased-in-early-onset-preeclampsia
#8
Philipp Velicky, Karin Windsperger, Karin Petroczi, Sophie Pils, Birgit Reiter, Tamara Weiss, Sigrid Vondra, Robin Ristl, Sabine Dekan, Christian Fiala, David E Cantonwine, Thomas F McElrath, Bernd Jilma, Martin Knöfler, Thomas Boehm, Jürgen Pollheimer
Human extravillous trophoblast (EVT) invasion of the pregnant uterus constitutes a pivotal event for the establishment of the maternal-fetal interface. Compromised EVT function manifesting in inadequate arterial remodeling is associated with the severe pregnancy disorder early-onset preeclampsia (eoPE). Recent studies suggest that EVTs invade the entire uterine vasculature including arteries, veins and lymphatics in the first trimester of pregnancy. We therefore hypothesized that EVT-derived factors accumulate in the circulation of pregnant women early in gestation and may serve to predict eoPE...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29658922/three-dimensional-rendering-and-analysis-of-immunolabeled-clarified-human-placental-villous-vascular-networks
#9
George Merz, Valerie Schwenk, Ruchit Shah, Carolyn Salafia, Phillip Necaise, Michael Joyce, Tom Villani, Michael Johnson, Nick Crider
Nutrient and gas exchange between mother and fetus occurs at the interface of the maternal intervillous blood and the vast villous capillary network that makes up much of the parenchyma of the human placenta. The distal villous capillary network is the terminus of the fetal blood supply after several generations of branching of vessels extending out from the umbilical cord. This network has a contiguous cellular sheath, the syncytial trophoblast barrier layer, which prevents mixing of fetal blood and the maternal blood in which it is continuously bathed...
March 29, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29657243/distinct-pattern-of-th17-treg-cells-in-pregnant-women-with-a-history-of-unexplained-recurrent-spontaneous-abortion
#10
Jinfeng Qian, Na Zhang, Jing Lin, Caiyan Wang, Xinyao Pan, Lanting Chen, Dajin Li, Ling Wang
The aim of the current study was to determine the pattern of immune cells and related functional molecules in peripheral blood and at the maternal-fetal interface in women with unexplained recurrent spontaneous abortion (URSA). In part I, 155 women were included and divided into four groups: non-pregnant controls with no history of URSA (NPCs), pregnant controls with no history of URSA (PCs), non-pregnant women with a history of URSA (NPUs), and pregnant women with a history of URSA (PUs). Venous blood samples were collected and analyzed...
April 15, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29651447/impaired-gal-9-dysregulates-the-pbmc-induced-th1-th2-imbalance-in-abortion-prone-matings
#11
Mengzhou He, Ming Jiang, Yuan Zhou, Fanfan Li, Meitao Yang, Yao Fan, Yin Xie, Rajluxmee Beejadhursing, Ling Feng, Dongrui Deng
Recurrent miscarriage is defined as the loss of 3 or more consecutive pregnancies; however, the underlying immunologic mechanisms that trigger pregnancy loss remain largely unelucidated. Galectin-9 (Gal-9) may modulate a variety of biologic functions and play an important role in Th1/Th2 immune deviation. To analyze the mechanism of Gal-9 in abortion, we used the classical abortion-prone mouse model (DBA/2-mated CBA/J mice) to detect the expression of Gal-9 at the maternal-fetal interface. We also mimicked the immune environment of pregnancy by culturing trophoblast cells with peripheral blood mononuclear cells (PBMCs) to explore how Gal-9 might be involved in the pathogenesis of abortion...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29643846/lilrb4-decrease-on-udcs-exacerbate-abnormal-pregnancy-outcomes-following-toxoplasma-gondii-infection
#12
Shaowei Zhan, Jing Zheng, Haixia Zhang, Mingdong Zhao, Xianbing Liu, Yuzhu Jiang, Chunyan Yang, Liqin Ren, Zhiqiang Liu, Xuemei Hu
Toxoplasma gondii ( T. gondii ) infection in early pregnancy can result in miscarriage, dead fetus, and other abnormalities. The LILRB4 is a central inhibitory receptor in uterine dendritic cells (uDCs) that plays essential immune-regulatory roles at the maternal-fetal interface. In this study, T. gondii -infected human primary uDCs and T. gondii -infected LILRB4-/- pregnant mice were utilized. The immune mechanisms underlying the role of LILRB4 on uDCs were explored in the development of abnormal pregnancy outcomes following T...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29642803/expression-of-n-acetylglucosaminyltransferase-iii-promotes-trophoblast-invasion-and-migration-in-early-human-placenta
#13
Qinyin Deng, Xiru Liu, Zhongmei Yang, Lan Xie
INTRODUCTION: Trophoblast migration and invasion at the maternal-fetal interface are crucial events for normal placentation and successful pregnancy. This progress is well controlled by many placenta-specific factors. Inadequate trophoblast invasion results in poor placenta plantation or even complications such as preeclampsia. It has been shown that N-acetylglucosaminyltransferase III (GnT-III) participates in tumor invasion and metastasis as a suppressor; however, the expression of GnT-III and its role in normal pregnancy is unclear...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29618777/three-macrophage-subsets-are-identified-in-the-uterus-during-early-human-pregnancy
#14
Xiangxiang Jiang, Mei-Rong Du, Min Li, Hongmei Wang
Macrophages are crucial for a successful pregnancy, and malfunctions of decidual macrophages correlate with adverse pregnancy outcomes, such as spontaneous abortion and preeclampsia. Previously, decidual macrophages were often thought to be a single population. In the present study, we identified three decidual macrophage subsets, CCR2-CD11cLO (CD11clow , ~80%), CCR2-CD11cHI (CD11chigh , ~5%), and CCR2+CD11cHI (CD11chigh , 10-15%), during the first trimester of human pregnancy by flow cytometry analysis. CCR2-CD11cLO macrophages are widely distributed in the decidua, while CCR2-CD11cHI and CCR2+CD11cHI macrophages are primarily detected close to extravillous trophoblast cells according to immunofluorescence staining...
April 4, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29608700/trophoblast-retrieval-and-isolation-from-the-cervix-origins-of-cervical-trophoblasts-and-their-potential-value-for-risk-assessment-of-ongoing-pregnancies
#15
Gerit Moser, Sascha Drewlo, Berthold Huppertz, D Randall Armant
BACKGROUND: Early during human development, the trophoblast lineage differentiates to commence placentation. Where the placenta contacts the uterine decidua, extravillous trophoblast (EVT) cells differentiate and invade maternal tissues. EVT cells, identified by expression of HLA-G, invade into uterine blood vessels (endovascular EVT), as well as glands (endoglandular EVT), and open such luminal structures towards the intervillous space of the placenta. Endoglandular invasion diverts the contents of uterine glands to the intervillous space, while glands near the margin of the placenta that also contain endoglandular EVT cells open into the reproductive tract...
March 28, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29588487/trophoblast-derived-cxcl16-induces-m2-macrophage-polarization-that-in-turn-inactivates-nk-cells-at-the-maternal-fetal-interface
#16
Xiao-Qiu Wang, Wen-Jie Zhou, Xin-Xin Hou, Qiang Fu, Da-Jin Li
Decidual macrophages (dMΦ) are distinct from the conventional macrophages present in other tissues and express M2 macrophage markers, but the molecular mechanisms of formation and the roles of M2 MΦ during pregnancy have not been completely elucidated. The crosstalk between decidual natural killer cells (dNK) and dMΦ plays an important role in the maintenance of maternal-fetal immune tolerance. Here, CXCL16 derived from first-trimester trophoblast cells induces the polarization of human M2 macrophages. The M2 MΦ polarized by CXCL16 exhibit decreased interleukin-15 production, which facilitates the inactivation of NK cells...
March 27, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29579271/interleukin-34-is-present-at-the-fetal-maternal-interface-and-induces-immunoregulatory-macrophages-of-a-decidual-phenotype-in-vitro
#17
R Lindau, R B Mehta, G E Lash, G Papapavlou, R Boij, G Berg, M C Jenmalm, J Ernerudh, J Svensson-Arvelund
STUDY QUESTION: Is the newly discovered cytokine interleukin (IL)-34 expressed at the human fetal-maternal interface in order to influence polarization of monocytes into macrophages of a decidual immunoregulatory phenotype? SUMMARY ANSWER: IL-34 was found to be present at the fetal-maternal interface, in both fetal placenta and maternal decidua, and it was able to polarize monocytes into macrophages of a decidual phenotype. WHAT IS KNOWN ALREADY: IL-34 was shown to bind to the same receptor as macrophage-colony stimulating factor (M-CSF), which has an important immunomodulatory role at the fetal-maternal interface, for example by polarizing decidual macrophages to an M2-like regulatory phenotype...
April 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29577513/placental-immune-state-shifts-with-gestational-age
#18
Emma L Lewis, Luz-Jeannette Sierra, Guillermo O Barila, Amy G Brown, Paige M Porrett, Michal A Elovitz
PROBLEM: Placental immunologic functions are implicated in both the maintenance of a healthy pregnancy and the pathogenesis of obstetric complications. Immune populations at the maternal-fetal interface are hypothesized to support fetomaternal tolerance, defend the fetus from infection, and contribute to labor initiation. Despite the many potential roles of placental immune cells in normal and abnormal pregnancy, little is known about placental immune population dynamics over gestation, particularly near parturition...
March 25, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29577468/maternal-fetal-cross-talk-through-cell-free-fetal-dna-telomere-shortening-microchimerism-and-inflammation
#19
Shi-Bin Cheng, Sarah Davis, Surendra Sharma
There exists a strong correlation between unscheduled inflammation at the maternal-fetal interface and the continuum of pregnancy complications. In normal pregnancy, immunological tolerance is established to protect the semi-allogeneic fetus. There has been extensive research on how the immunity, endovascular trophoblast migration, and hormonal nexus are orchestrated during pregnancy at the maternal-fetal interface to program a normal pregnancy outcome. It is not clear what contributes to the plasticity of uterine immune tolerance, fetal survial, and long-term post-partum health of the mother and the offspring...
March 25, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29566610/histologic-changes-associated-with-placental-separation-in-gilts-infected-with-porcine-reproductive-and-respiratory-syndrome-virus
#20
Predrag Novakovic, Susan E Detmer, Muhammad Suleman, Carol M Malgarin, Daniel J MacPhee, John C S Harding
The placenta is a vital organ providing the developing fetus with nutrient and gas exchange, thermoregulation, and waste elimination necessary for fetal development, as well as producing hormones to maintain pregnancy. It is hypothesized that fetal pig death in porcine reproductive and respiratory syndrome may be attributed to pathology of the maternal-fetal interface leading to premature placental separation. This study was designed to evaluate the chronologic progression of porcine reproductive and respiratory syndrome virus (PRRSV)-induced lesions at the maternal-fetal interface, with particular focus on placental separation in experimentally challenged third-trimester gilts...
January 1, 2018: Veterinary Pathology
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