Read by QxMD icon Read

maternal-fetal interface

Céline Méhats, Louis Marcellin, Thomas Schmitz
No abstract text is available yet for this article.
March 2018: Médecine Sciences: M/S
Haiying Rao, Yuxiang Bai, Qingshu Li, Baimei Zhuang, Yu Yuan, Yamin Liu, Wei Peng, Philip N Baker, Chao Tong, Xin Luo, Hongbo Qi
Preeclampsia (PE) is characterized by abnormal placentation in the early stages of pregnancy. Adequate migration and invasion of trophoblasts into the uterine wall and spiral arteries to form a functional maternal-fetal interface are pivotal for normal placentation, but the exact mechanism remains unclear. Growing evidence has revealed that special AT-rich sequence-binding protein 1 (SATB1) is a tumor promoter that participates in cancer cell migration and invasion. However, the expression and function of SATB1 in trophoblasts is unknown...
March 13, 2018: Biology of Reproduction
Dorien Reijnders, Chin-Chi Liu, Xinjing Xu, Anna Zhao, Kelsey Olson, Scott D Butler, Nataki C Douglas, Jenny L Sones
Preeclampsia (PE), a hypertensive disease of pregnancy, is a leading cause of fetal and maternal morbidity/mortality. Early angiogenic and inflammatory disturbances within the placenta are thought to underlie the development of the maternal PE syndrome and poor pregnancy outcomes. However, the exact etiology remains largely unknown. Here, we use the BPH/5 mouse model of PE to elucidate the way in which inflammation early in pregnancy contributes to abnormal expression of angiogenic factors at the maternal-fetal interface...
March 9, 2018: Physiological Genomics
David E Lowe, Jennifer R Robbins, Anna I Bakardjiev
Intrauterine infections lead to serious complications for mother and fetus including preterm birth, maternal and fetal death, and neurologic sequelae in the surviving offspring. Improving maternal-child heath is a global priority. Yet, the development of strategies to prevent and treat pregnancy-related diseases has lagged behind progress made in other medical fields. One of the challenges is finding tractable model systems that replicate the human maternal-fetal interface. Animal models offer the ability to study pathogenesis and host defenses in vivo However, the anatomy of the maternal-fetal interface is highly divergent across species...
February 26, 2018: Infection and Immunity
T Meuleman, J Drabbels, J M M van Lith, O M Dekkers, E Rozemuller, M Cretu-Stancu, F H J Claas, K W M Bloemenkamp, M Eikmans
HLA-G expressed by trophoblasts at the fetal-maternal interface and its soluble form have immunomodulatory effects. HLA-G expression depends on the combination of DNA polymorphisms. We hypothesized that combinations of specific single nucleotide polymorphisms (SNPs) in the 3'untranslated region (3'UTR) of HLA-G play a role in unexplained recurrent miscarriage. In a case control design, 100 cases with at least three unexplained consecutive miscarriages prior to the 20th week of gestation were included. Cases were at time of the third miscarriage younger than 36 years, and they conceived all their pregnancies from the same partner...
February 7, 2018: Journal of Reproductive Immunology
Qinyin Deng, Nanlin Yin, Ying Chen, Nan Shan, Xiru Liu, Hongbo Qi
OBJECTIVE: Many studies have confirmed that N-acetylglucosaminyltransferase III (GnT-III) is correlated with tumor invasion and metastasis. However, the expression of GnT-III and its role in normal pregnancy and preeclampsia (PE) has not been reached. So the primary objective of this study is to determine GnT-III expression in normal pregnancy and whether its expression is vulnerable to oxidative stress in the trophoblast cells. METHODS: Human first trimester villous tissues from normal pregnancies and third trimester placentas from pregnancies with or without preeclampsia (PE) were used for the detection of GnT-III expression...
February 21, 2018: Journal of Maternal-fetal & Neonatal Medicine
Agata Sakowicz
The transcription factor kappa B (NFĸB) controls the expression of over 400 genes, some of which are associated with reproductive events. During implantation, immune cells accumulate in the maternal-fetal interface; they secrete inflammatory mediators under the control of NFĸB, whose level also rises. NFĸB is then downregulated to maintain gestation, but its level rises again before birth to manage prostaglandin, cytokine and chemokine synthesis and stimulate uterine contraction. This review summarises the current state of knowledge about NFĸB and its role in the molecular regulation of processes related to pregnancy development...
February 20, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
Yi Xu, Roberto Romero, Derek Miller, Pablo Silva, Bogdan Panaitescu, Kevin R Theis, Afrah Arif, Sonia S Hassan, Nardhy Gomez-Lopez
PROBLEM: Pathological inflammation is causally linked to preterm labor and birth, the leading cause of neonatal morbidity and mortality worldwide. Our aims were to investigate whether (i) the newly described family of innate lymphoid cells (ILCs) was present at the human maternal-fetal interface and (ii) ILC inflammatory subsets were associated with the pathological process of preterm labor. METHODS OF STUDY: Decidual leukocytes were isolated from women with preterm or term labor as well as from gestational age-matched non-labor controls...
February 19, 2018: American Journal of Reproductive Immunology: AJRI
Stefan Markovic, Anne Fages, Tangi Roussel, Ron Hadas, Alexander Brandis, Michal Neeman, Lucio Frydman
Placental functions, including transport and metabolism, play essential roles in pregnancy. This study assesses such processes in vivo , from a hyperpolarized MRI perspective. Hyperpolarized urea, bicarbonate, and pyruvate were administered to near-term pregnant rats, and all metabolites displayed distinctive behaviors. Little evidence of placental barrier crossing was observed for bicarbonate, at least within the timescales allowed by 13 C relaxation. By contrast, urea was observed to cross the placental barrier, with signatures visible from certain fetal organs including the liver...
February 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
Sonia DaSilva-Arnold, Stacy Zamudio, Abdulla Al-Khan, Jesus Alvarez-Perez, Ciaran Mannion, Christopher Koenig, Davlyn Luke, Anisha Perez, Margaret Petroff, Manuel Alvarez, Nicholas P Illsley
Differentiation of first trimester human placental cytotrophoblast from an anchorage-dependent epithelial phenotype into the mesenchymal-like invasive extravillous trophoblast is crucial in the development of the maternal-fetal interface. We showed previously that differentiation of first trimester cytotrophoblast to extravillous trophoblast involves an epithelial-mesenchymal transition (EMT). Here we compare the epithelial-mesenchymal characteristics of cytotrophoblast (CTB) and extravillous trophoblast (EVT) derived from normal third trimester placenta or placenta previa versus abnormally invasive placenta (AIP)...
February 9, 2018: Biology of Reproduction
Yuan Zhang, Ying Wang, Ming-Qing Li, Jie Duan, Deng-Xuan Fan, Li-Ping Jin
Decidual immune cells (DICs), consisting of both innate and adaptive immune cells, have a pivotal role in maintaining immune tolerance for normal pregnancy. Our previous study demonstrated that interleukin (IL)-25 stimulates the proliferation of decidual stromal cells (DSCs) in an autocrine manner. However, the role of IL-25 in functional regulation of DICs is largely unknown. Flow cytometry was used to analyze the expression of IL-25 and its receptor (IL-17RB) in DICs, and the effect of IL-25 on the expression of Ki-67, IL-4, IL-10, interferon (IFN)-γ and transforming growth factor (TGF)-β in decidual γδT cells...
February 2018: Experimental and Therapeutic Medicine
Tina A Nguyen, Daniel A Kahn, Andrea I Loewendorf
INTRODUCTION: Maternal-fetal chimerism is miniscule, a testament to the integrity of the uteroplacental interface. The soundness of this border region is potentially altered through cesarean delivery of prior babies with uncertain consequences for the following pregnancies. METHODS: Using multicolor flow cytometry and quantitative PCR of non-inherited maternal antigens we performed a retrospective case control pilot study and formulated the null hypothesis that placental implantation over a prior uterine scar does not result in the presence of memory Treg (CD45RO+) in the fetus...
February 12, 2018: Immunity, Inflammation and Disease
Nicole S Olgun
During gestation, the immune response of the placenta to viruses and other pathogens plays an important role in determining a pregnant woman's vulnerability toward infectious diseases. Located at the maternal- fetal interface, trophoblast cells serve to minimize the spread of viruses between the host and developing fetus through an intricate system of innate antiviral immune signaling. Adverse pregnancy outcomes, ranging from learning disabilities to preterm birth and fetal death, are all documented results of a viral breach in the placental barrier...
January 30, 2018: Current Pharmaceutical Design
Emma L Mohr, Lindsey N Block, Christina M Newman, Laurel M Stewart, Michelle Koenig, Matthew Semler, Meghan E Breitbach, Leandro B C Teixeira, Xiankun Zeng, Andrea M Weiler, Gabrielle L Barry, Troy H Thoong, Gregory J Wiepz, Dawn M Dudley, Heather A Simmons, Andres Mejia, Terry K Morgan, M Shahriar Salamat, Sarah Kohn, Kathleen M Antony, Matthew T Aliota, Mariel S Mohns, Jennifer M Hayes, Nancy Schultz-Darken, Michele L Schotzko, Eric Peterson, Saverio Capuano, Jorge E Osorio, Shelby L O'Connor, Thomas C Friedrich, David H O'Connor, Thaddeus G Golos
Congenital Zika virus (ZIKV) infection impacts fetal development and pregnancy outcomes. We infected a pregnant rhesus macaque with a Puerto Rican ZIKV isolate in the first trimester. The pregnancy was complicated by preterm premature rupture of membranes (PPROM), intraamniotic bacterial infection and fetal demise 49 days post infection (gestational day 95). Significant pathology at the maternal-fetal interface included acute chorioamnionitis, placental infarcts, and leukocytoclastic vasculitis of the myometrial radial arteries...
2018: PloS One
Gareth A Nye, Emma Ingram, Edward D Johnstone, Oliver E Jensen, Henning Schneider, Rohan M Lewis, Igor L Chernyavsky, Paul Brownbill
The placenta is crucial for life. It is an ephemeral but complex organ acting as the barrier interface between maternal and fetal circulations, providing exchange of gases, nutrients, hormones, waste products and immunoglobulins. Many gaps exist in our understanding of the detailed placental structure and function, particularly in relation to oxygen handling and transfer in healthy and pathological states in utero. Measurements to understand oxygen transfer in vivo in the human are limited, with no general agreement on the most appropriate methods...
January 26, 2018: Journal of Physiology
Marcia Arenas-Hernandez, Nardhy Gomez-Lopez, Valeria Garcia-Flores, Claudia Rangel-Escareño, Luis M Alvarez-Salas, Natalia Martinez-Acuña, Joel A Vazquez-Perez, Rodrigo Vega-Sanchez
Prior to and during the process of human labor, maternal circulating leukocytes infiltrate the maternal-fetal interface (choriodecidua) and become activated resembling choriodecidual leukocytes. Since, there is no evidence comparing maternal circulating and choriodecidual leukocytes, herein, we characterized their transcriptome and explored the biological processes enriched in choriodecidual leukocytes. From women undergoing spontaneous term labor we isolated circulating and choriodecidual leukocytes, performed microarray analysis (n = 5) and qRT-PCR validation (n = 9) and interaction network analysis with up-regulated genes...
January 24, 2018: Genes and Immunity
Shao-Liang Yang, Tian-Tian Niu, Xue-Lian Li, Da-Jin Li, Ming-Qing Li, Hai-Yan Wang
Recurrent spontaneous abortion (RSA) is a common health problem that affects about 5% of fertile women, when it occurs for unknown reasons, it is called unexplained recurrent spontaneous abortion (URSA). Traditional Chinese medicine, such as Bu-Shen-Yi-Qi formula which consists of Dangshen, Tusizi, Baizhu, Baishuo, Duzhong, Sangjisheng, Sugeng, and Tiaohuangqin, has played an invaluable role in the treatment of RSA since ancient times. However, the mechanism of how it takes effect is still not clear. To identify Bu-Shen-Yi-Qi formula could modulate immune condition at maternal-fetal interface via its effect on trophoblasts, HTR-8 of different treatment were co-cultured with peripheral or decidual natural killer (NK) cells, and the receptors such as NKP30 and NKP46 expression on NK cells were measured by flow cytometry (FCM)...
January 15, 2018: Gynecological Endocrinology
Jason A Koroghli, Elizabeth Floyd, Misha Regouski, Kerry Rood, Kirsten Gash, Kip Panter, Rusty Stott, Christopher J Davies, Irina A Polejaeva, Heloisa M Rutigliano
The hypothesis of this study was that the leukocyte populations and expression levels of genes related to immune response, growth factors and apoptosis would be altered at the fetal-maternal interface in somatic cell nuclear transfer (SCNT)-generated sheep pregnancies. Placental and endometrial samples from sheep pregnancies established by SCNT and natural breeding (control) were collected at 45 days and at term. Expression of genes related to growth factors, apoptosis and immune response was examined using quantitative reverse transcription polymerase chain reaction...
January 15, 2018: Reproduction, Fertility, and Development
Stephanie E Ander, Elizabeth N Rudzki, Nitin Arora, Yoel Sadovsky, Carolyn B Coyne, Jon P Boyle
Toxoplasma gondii is a major source of congenital disease worldwide, but the cellular and molecular factors associated with its vertical transmission are largely unknown. In humans, the placenta forms the key interface between the maternal and fetal compartments and forms the primary barrier that restricts the hematogenous spread of microorganisms. Here, we utilized primary human trophoblast (PHT) cells isolated from full-term placentas and human midgestation chorionic villous explants to determine the mechanisms by which human trophoblasts restrict and respond to T...
January 9, 2018: MBio
Amir Salek Farrokhi, Amir-Hassan Zarnani, Seyed Mohammad Moazzeni
The imbalance of Th1/Th2 cytokines is well known in recurrent spontaneous abortion (RSA) mouse model. Mesenchymal stem cells (MSCs) possess potent immunoregulatory properties that could modulate the Th1 cytokine responses in benefit of Th2 types. In this study, we aimed to analyze the local and systemic balance of Th1/Th2 cytokines following MSCs therapy. Syngeneic adipose derived MSCs were administered to abortion prone mice during the implantation window. The abortion rate was determined and IL-4, IL-6, IL-12, IL-2, IFN-γ and GM-CSF gene expression was evaluated by Real-Time-PCR in decidual and placental tissues of pregnant mice at day 13...
January 6, 2018: Transplant Immunology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"