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maternal-fetal interface

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https://www.readbyqxmd.com/read/29123519/two-distinct-myeloid-subsets-at-the-term-human-fetal-maternal-interface
#1
Maria Laura Costa, Michelle L Robinette, Mattia Bugatti, Mark S Longtine, Bryanne N Colvin, Erica Lantelme, William Vermi, Marco Colonna, D Michael Nelson, Marina Cella
During pregnancy, immune cells infiltrate the placenta at different stages of fetal development. NK cells and macrophages are the most predominant cell types. These immune cells play pleiotropic roles, as they control spiral artery remodeling to ensure appropriate blood supply and maintain long-term tolerance to a true allograft; yet, they must be able to mount appropriate immune defenses to pathogens that may threaten the fetus. Whether the same cell type accomplishes all these tasks or if there are dedicated subsets remains controversial...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29121458/placental-drug-transport-on-a-chip-a-microengineered-in-vitro-model-of-transporter-mediated-drug-efflux-in-the-human-placental-barrier
#2
Cassidy Blundell, Yoon-Suk Yi, Lin Ma, Emily R Tess, Megan J Farrell, Andrei Georgescu, Lauren M Aleksunes, Dongeun Huh
The current lack of knowledge about the effect of maternally administered drugs on the developing fetus is a major public health concern worldwide. The first critical step toward predicting the safety of medications in pregnancy is to screen drug compounds for their ability to cross the placenta. However, this type of preclinical study has been hampered by the limited capacity of existing in vitro and ex vivo models to mimic physiological drug transport across the maternal-fetal interface in the human placenta...
November 9, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29083087/upregulation-of-tim-3-expression-at-feto-maternal-interface-may-explain-embryo-survival-in-the-cbaxdba-2-model-of-abortion
#3
Fanfan Li, Jing Dang, Min Jiang, Mengzhou He, Meitao Yang, Jing Li, Haiyan Hao, Yuan Zhou, Wei Zuo, Yin Xie, Dongrui Deng
PROBLEM: To understand the mechanisms of action of Tim-3 at the maternal-fetal interface and explore how Tim-3 might be involved in the pathogenesis of abortion by constructing an in vitro trophoblast-lymphocyte system. METHODS OF STUDY: Female CBA/J × male DBA/2 matings were used as the abortion-prone model and CBA/J × male BALB/c matings as control. The expression of Tim-3 at the maternal-fetal interface and in the peripheral blood lymphocytes was measured by immunohistochemistry and Western blotting...
October 30, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29066285/understanding-vitamin-d-metabolism-in-pregnancy-from-physiology-to-pathophysiology-and-clinical-outcomes
#4
Spyridon N Karras, Carol L Wagner, V Daniel Castracane
This critical time frame of intrauterine life development is considered of major importance on the metabolic imprinting of overall health of the offspring, in later life. This requires a delicate immune balance that nurtures the allogeneic fetus, while maintaining reactivity against pathogens. Dysregulation of these tightly controlled biophenomena at a systemic and placental level, have been considered as a potential mechanism mediating pathogenesis of preeclampsia and spontaneous birth. In this context, vitamin D has been considered as a significant regulator of both innate and adaptive immunity by regulating cell proliferation, differentiation and apoptosis...
October 21, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29065800/fatty-acid-transporter-expression-and-regulation-is-impaired-in-placental-macrovascular-endothelial-cells-in-obese-women
#5
Xiaohua Yang, Patricia Glazebrook, Geraldine C Ranasinghe, Maricela Haghiac, Virtu Calabuig-Navarro, Judi Minium, Perrie O'Tierney-Ginn
OBJECTIVE: Fetal fatty acid (FA) delivery is ultimately controlled by placental transport. Focus has been the maternal-placental interface, but regulation at the feto-placental interface is unknown. METHODS: Placental macrovascular endothelial cells (EC) (n = 4/group) and trophoblasts (TB) (n = 5/group) were isolated from lean (pregravid BMI < 25 kg/m(2)) and obese (body mass index (BMI) > 30) women. Fatty acid transporters FAT/CD36, FABPpm, FATP4, FABP 3, 4 and 5, PLIN2 and PPARα, δ, γ expression, was measured in EC and TB...
October 24, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29060433/ctg-analyzer-a-graphical-user-interface-for-cardiotocography
#6
Agnese Sbrollini, Angela Agostinelli, Luca Burattini, Micaela Morettini, Francesco Di Nardo, Sandro Fioretti, Laura Burattini
Cardiotocography (CTG) is the most commonly used test for establishing the good health of the fetus during pregnancy and labor. CTG consists in the recording of fetal heart rate (FHR; bpm) and maternal uterine contractions (UC; mmHg). FHR is characterized by baseline, baseline variability, tachycardia, bradycardia, acceleration and decelerations. Instead, UC signal is characterized by presence of contractions and contractions period. Such parameters are usually evaluated by visual inspection. However, visual analysis of CTG recordings has a well-demonstrated poor reproducibility, due to the complexity of physiological phenomena affecting fetal heart rhythm and being related to clinician's experience...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29055791/the-role-of-decidual-immune-cells-on-human-pregnancy
#7
REVIEW
Su Liu, Lianghui Diao, Chunyu Huang, Yuye Li, Yong Zeng, Joanne Y H Kwak-Kim
The maternal-fetal interface undergoes dynamic changes to allow the fetus to grow and develop in the uterus, despite being recognized by the maternal immune cells. Within the innate immune system, decidual natural killer cells and antigen presenting cells (including macrophages and dendritic cells) that comprise a large proportion of the decidual leukocyte populations play an important role in modulating trophoblast invasion, angiogenesis and vascular remodeling. On the other hand, within the adaptive immune system, CD8(+) T cells, effector CD4(+) T cells, Foxp3(+) regulatory T cells and CD4(+)HLA-G(+) suppressor T cells are identified as potential players in maintaining immune tolerance toward the semi-allogeneic fetus...
October 18, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29049918/dc-sign-expression-in-hofbauer-cells-may-play-an-important-role-in-immune-tolerance-in-fetal-chorionic-villi-during-the-development-of-preeclampsia
#8
Seung Woo Yang, Eun Hee Cho, So Young Choi, Yun Kyung Lee, Jae Hyun Park, Min Kyung Kim, Jin Yeon Park, Hyeong Jwa Choi, Jeong Ik Lee, Hyun Myung Ko, Seung Hwa Park, Han Sung Hwang, Young Sun Kang
Immune tolerance at feto-maternal interfaces is a complex phenomenon. Although maternal decidual macrophages are well-known immune cells, little is known about fetal-derived macrophages (Hofbauer cells) within chorionic villi. Preeclampsia (PE) is a major cause of maternal mortality in the field of obstetrics, and the innate immunological role of maternal decidual macrophages is well known. In this study, we assessed the differential phenotypes and marker expression in fetal macrophages, known as dendritic cell-specific ICAM-grabbing non-integrin (DC-SIGN)-positive Hofbauer cells...
September 28, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29039177/-the-involvement-of-galectin-1-in-implantation-and-pregnancy-maintenance-at-the-maternal-fetal-interface
#9
Minyue Tang, Yimin Zhu
As a member of galectins family, galectin-1(Gal-1)is widely expressed in tissues and cells, and participates in a variety of physiological and pathological processes, such as cell adhesion, proliferation, apoptosis and inflammatory reaction. Recently, it has been found that Gal-1 is highly expressed at the maternal-fetal interface and plays important roles in trophoblast cell proliferation, differentiation and invasion, endometrial receptivity, placental angiogenesis and maternal-fetal immune tolerance. In this review, we outline the expression of Gal-1 at the maternal-fetal interface and the involvement of Gal-1 in embryo implantation and pregnancy maintenance, to provide novel insights for the early diagnosis, prognostic assessment and treatment of early pregnancy loss and pregnancy-related diseases...
May 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/29030900/computational-flow-cytometry-analysis-reveals-a-unique-immune-signature-of-the-human-maternal-fetal-interface
#10
Jessica Vazquez, Melina Chavarria, Yan Li, Gladys E Lopez, Aleksandar K Stanic
PROBLEM: Decidual immune dysregulation is thought to underlie major pregnancy disorders; however, incomplete understanding of the decidual immune interface has hampered the mechanistic investigation. METHOD OF STUDY: Human term decidua was collected, and single-cell phenotypic information was acquired by highly polychromatic flow cytometry. Cellular identity analysis was performed with t-distributed stochastic neighbor embedding, DensVM clustering, and matched to CellOntology database...
October 14, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29020789/-the-role-of-maternal-imunity-and-woman%C3%A2-s-microbiome-in-the-pathogenesis-of-preterm-labor
#11
M Koucký, K Malíčková, J Hrdý, A Černý, H Hrbáčková, P Šimják, A Pařízek
OBJECTIVE: To summarize available data concerning the role of maternal imunity and woman´s microbiome in the pathogenesis of preterm labor and their use in clinical practice. SETTING: Department of Obstetrics and Gynecology od the First Faculty of Medicine, Charles University in Prague, and General Teaching Hospital. DESIGN: Review article. METHODS: Compilation od published data from scientific literature. CONCLUSION: Preterm labor complicates approximately 10% of all pregnancies and represents a serious medical, social and economic problem...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28986438/decidual-t-cells-exhibit-a-highly-differentiated-phenotype-and-demonstrate-potential-fetal-specificity-and-a-strong-transcriptional-response-to-ifn
#12
Richard M Powell, David Lissauer, Jennifer Tamblyn, Andrew Beggs, Philip Cox, Paul Moss, Mark D Kilby
Immune tolerance during human pregnancy is maintained by a range of modifications to the local and systemic maternal immune system. Lymphoid infiltration is seen at the implantation site of the fetal-maternal interface, and decidual NK cells have been demonstrated to facilitate extravillous trophoblast invasion into maternal decidua during the first trimester, optimizing hemochorial placentation. However, although there is considerable T cell infiltration of the maternal decidua, the functional properties of this T cell response remain poorly defined...
November 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28975683/involvement-of-the-jak-stat-pathway-in-collagen-regulation-of-decidual-nk-cells
#13
Qiang Fu, Yufei Sun, Yu Tao, Hailan Piao, Xiaoqiu Wang, Xiying Luan, Meirong Du, Dajin Li
PROBLEM: The mechanisms underlying the regulation of decidual natural killer cells (dNKs) at the maternal-fetal interface are unclear. METHOD OF STUDY: Primary trophoblasts (TROs), decidual stromal cells (DSCs), and dNKs were cocultured, and responses to LAIR-2 (LAIR-1 inhibitor) and P4H shRNA (collagen inhibitor) were studied. RESULTS: Coculture of dNKs with primary TROs/DSCs resulted in downregulation of Th1 cytokine production by dNKs. These effects were abrogated by LAIR-2 and P4H shRNA...
October 4, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28956761/apobec3a-is-upregulated-by-human-cytomegalovirus-hcmv-in-the-maternal-fetal-interface-acting-as-an-innate-anti-hcmv-effector
#14
Yiska Weisblum, Esther Oiknine-Djian, Zichria Zakay-Rones, Olesya Vorontsov, Ronit Haimov-Kochman, Yuval Nevo, David Stockheim, Simcha Yagel, Amos Panet, Dana G Wolf
Human cytomegalovirus (HCMV) is the leading cause of congenital infection and is associated with a wide range of neurodevelopmental disabilities and intrauterine growth restriction. Yet our current understanding of the mechanisms modulating transplacental HCMV transmission is poor. The placenta, given its critical function in protecting the fetus, has evolved effective yet largely uncharacterized innate immune barriers against invading pathogens. Here we show that the intrinsic cellular restriction factor apolipoprotein B editing catalytic subunit-like 3A (APOBEC3A [A3A]) is profoundly upregulated following ex vivo HCMV infection in human decidual tissues-constituting the maternal aspect of the placenta...
December 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28937611/hcg-biological-functions-and-clinical-applications
#15
REVIEW
Chinedu Nwabuobi, Sefa Arlier, Frederick Schatz, Ozlem Guzeloglu-Kayisli, Charles Joseph Lockwood, Umit Ali Kayisli
Human chorionic gonadotropin (hCG) is produced primarily by differentiated syncytiotrophoblasts, and represents a key embryonic signal that is essential for the maintenance of pregnancy. hCG can activate various signaling cascades including mothers against decapentaplegic homolog 2 (Smad2), protein kinase C (PKC), and/or protein kinase A (PKA) in several cells types by binding to luteinizing hormone/chorionic gonadotropin receptor (LHCGR) or potentially by direct/indirect interaction with transforming growth factor beta receptor (TGFβR)...
September 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28923940/defective-decidualization-during-and-after-severe-preeclampsia-reveals-a-possible-maternal-contribution-to-the-etiology
#16
Tamara Garrido-Gomez, Francisco Dominguez, Alicia Quiñonero, Patricia Diaz-Gimeno, Mirhan Kapidzic, Matthew Gormley, Katherine Ona, Pablo Padilla-Iserte, Michael McMaster, Olga Genbacev, Alfredo Perales, Susan J Fisher, Carlos Simón
In preeclampsia (PE), cytotrophoblast (CTB) invasion of the uterus and spiral arteries is often shallow. Thus, the placenta's role has been a focus. In this study, we tested the hypothesis that decidual defects are an important determinant of the placental phenotype. We isolated human endometrial stromal cells from nonpregnant donors with a previous pregnancy that was complicated by severe PE (sPE). Compared with control cells, they failed to decidualize in vitro as demonstrated by morphological criteria and the analysis of stage-specific antigens (i...
October 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28922401/rab11-family-expression-in-the-human-placenta-localization-at-the-maternal-fetal-interface
#17
Elizabeth S Taglauer, Patrycja A Artemiuk, Sara R Hanscom, Andrew J Lindsay, Danielle Wuebbolt, Fionnuala M Breathnach, Elizabeth C Tully, Amir R Khan, Mary W McCaffrey
Rab proteins are a family of small GTPases involved in a variety of cellular processes. The Rab11 subfamily in particular directs key steps of intracellular functions involving vesicle trafficking of the endosomal recycling pathway. This Rab subfamily works through a series of effector proteins including the Rab11-FIPs (Rab11 Family-Interacting Proteins). While the Rab11 subfamily has been well characterized at the cellular level, its function within human organ systems is still being explored. In an effort to further study these proteins, we conducted a preliminary investigation of a subgroup of endosomal Rab proteins in a range of human cell lines by Western blotting...
2017: PloS One
https://www.readbyqxmd.com/read/28920512/rhythmic-three-part-harmony-the-complex-interaction-of-maternal-placental-and-fetal-circadian-systems
#18
Peter J Mark, Rachael C Crew, Michaela D Wharfe, Brendan J Waddell
From the perspective of circadian biology, mammalian pregnancy presents an unusual biological scenario in which an entire circadian system (i.e., that of the fetus) is embodied within another (i.e., that of the mother). Moreover, both systems are likely to be influenced at their interface by a third player, the placenta. Successful pregnancy requires major adaptations in maternal physiology, many of which involve circadian changes that support the high metabolic demands of the growing fetus. A functional role for maternal circadian adaptations is implied by the effects of circadian disruption, which result in pregnancy complications including higher risks for miscarriage, preterm labor, and low birth weight...
September 1, 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/28910635/gestational-stage-and-ifn-%C3%AE-signaling-regulate-zikv-infection-in-utero
#19
Brett W Jagger, Jonathan J Miner, Bin Cao, Nitin Arora, Amber M Smith, Attila Kovacs, Indira U Mysorekar, Carolyn B Coyne, Michael S Diamond
Although Zika virus (ZIKV)-induced congenital disease occurs more frequently during early stages of pregnancy, its basis remains undefined. Using established type I interferon (IFN)-deficient mouse models of ZIKV transmission in utero, we found that the placenta and fetus were more susceptible to ZIKV infection at earlier gestational stages. Whereas ZIKV infection at embryonic day 6 (E6) resulted in placental insufficiency and fetal demise, infections at midstage (E9) resulted in reduced cranial dimensions, and infection later in pregnancy (E12) caused no apparent fetal disease...
September 13, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28903546/cellular-and-molecular-mechanisms-of-viral-infection-in-the-human-placenta
#20
Moises León-Juárez, Macario Martínez-Castillo, Luis Didier González-García, Addy Cecilia Helguera-Repetto, Verónica Zaga-Clavellina, Julio García-Cordero, Arturo Flores-Pliego, Alma Herrera-Salazar, Edgar Ricardo Vázquez-Martínez, Enrique Reyes-Muñoz
The placenta is a highly specialized organ that is formed during human gestation for conferring protection and generating an optimal microenvironment to maintain the equilibrium between immunological and biochemical factors for fetal development. Diverse pathogens, including viruses, can infect several cellular components of the placenta, such as trophoblasts, syncytiotrophoblasts and other hematopoietic cells. Viral infections during pregnancy have been associated with fetal malformation and pregnancy complications such as preterm labor...
September 29, 2017: Pathogens and Disease
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