Yun Zeng, Jessie Teo, Jing-Quan Lim, Wei-Kiat Hoi, Chee-Leong Kee, Min-Yong Low, Xiaowei Ge
Analysis of N-nitroso folic acid, a nitrosamine impurity found in folic acid, is challenging due to the complex sample matrices. Many of such supplements contain not only a variety of vitamins, including vitamin A, Bs, C, D and E, but also other ingredients such as minerals, docosahexaenoic acid (DHA), glucose syrup, sugar, and herbs. On the other hand, the strength of folic acid is typically low, ranging from 50 µg to 5 mg per unit. In this study, a highly selective and sensitive LC-MS/MS method was developed to accurately quantify N-nitroso folic acid in supplements containing folic acid...
December 15, 2023: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment