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multivitamins and mortality

Swapnalee Sarmah, Pooja Muralidharan, James A Marrs
Congenital anomalies, congenital defects, or birth defects are significant causes of death in infants. The most common congenital defects are congenital heart defects (CHDs) and neural tube defects (NTDs). Defects induced by genetic mutations, environmental exposure to toxins, or a combination of these effects can result in congenital malformations, leading to infant death or long-term disabilities. These defects produce significant mortality and morbidity in the affected individuals, and families are affected emotional and financially...
October 7, 2016: Birth Defects Research. Part C, Embryo Today: Reviews
Laura Astolfi, Edi Simoni, Filippo Valente, Sara Ghiselli, Stavros Hatzopoulos, Milvia Chicca, Alessandro Martini
Cisplatin (Cpt) is known to induce a high level of oxidative stress, resulting in an increase of reactive oxygen species damaging the inner ear and causing hearing loss at high frequencies. Studies on animal models show that antioxidants may lower Cpt-induced ototoxicity. The aim of this study is to evaluate the ototoxic effects of two different protocols of Cpt administration in a Sprague-Dawley rat model, and to test in the same model the synergic protective effects of a solution of coenzyme Q10 terclatrate and Acuval 400®, a multivitamin supplement containing antioxidant agents and minerals (Acu-Qter)...
2016: PloS One
Shaad Abqari, Akash Gupta, Tabassum Shahab, M U Rabbani, S Manazir Ali, Uzma Firdaus
INTRODUCTION: Congenital heart defects (CHDs) are an important cause of mortality and morbidity in children representing a major global health burden. It is thus important to determine their prevalence and spectrum and identify risk factors associated with the development of heart defects. MATERIALS AND METHODS: A case-control study was carried out in the Department of Pediatrics and Center of Cardiology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India, from February 2014 to August 2015...
September 2016: Annals of Pediatric Cardiology
Hans K Biesalski, Jana Tinz
Multivitamin/mineral supplements (MVM) are widely used in many populations. In particular, in pregnant women, MVM together with iron and folic acid are recommended to improve birth outcome and reduce low birth weight and rates of miscarriage. However, MVM use is common in the general population. This raises questions regarding the safety of long-term use of these supplements. To estimate the safety of MVM use, we performed a literature search for randomized, controlled studies for supplements with a combination of at least nine vitamins and three minerals at a maximum concentration of 100% of the recommended dietary allowance...
March 4, 2016: Nutrition
Edmond K Kabagambe, Amara E Ezeamama, David Guwatudde, Hannia Campos, Wafaie Fawzi
BACKGROUND: Fatty-acids, including n6 series, modulate immune function but their effect on CD4 cell counts, death or hospitalization in HIV-infected patients on antiretroviral therapy is unknown. METHODS: In a randomized trial for effects of multivitamins in HIV-infected patients in Uganda, we used gas chromatography to measure plasma n6-fatty acids at baseline, determined CD4 counts at baseline, 3, 6, 12 and 18 months and recorded hospitalization or death events...
August 13, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Mohammad Aminul Islam, Masahide Nishibori
The experiments were carried out to measure the effect of multivitamin, acidifier and Azolla on growth performance, profitability and lipid profiles of blood of broiler chicken to produce safe and cost effective broiler. In experiment 1, 240 day-old Cobb-500 broiler chicks were fed diets; D1 (control), D2 (D1 with 1 ml multivitamin/liter water), D3 (D1 with 1 ml acidifier/liter water), D4 (D1 with 1 ml multivitamin and 2 ml acidifier/liter water) having 3 replications in each, and 20 chicks/ replication. In experiment 2, 150 day-old Cobb-500 broiler chicks were fed diets; T1 (control), T2 (5% Azolla in the diet), T3 (7% Azolla in the diet) and T4 (T1 with 1 ml multivitamin and 1 ml acidifier/liter water) having 3 replications in each, and 20 chicks/replication in control, and 10 chicks/replication in the rest dietary treatment groups for 35 days...
August 10, 2016: Asian-Australasian Journal of Animal Sciences
Konrad H Stopsack, Alexandra J Greenberg, Lorelei A Mucci
PURPOSE: Most prostate cancer patients also have comorbidities that are treated with both prescription and nonprescription medications; furthermore, many use dietary supplements. We assess their association with prognosis after prostate cancer diagnosis, and we discuss methodological challenges and clinical implications. METHODS: We reviewed high-quality observational studies investigating the association of commonly used medications and supplements with prostate cancer-specific mortality...
August 4, 2016: World Journal of Urology
Kerri B Gosselin, Said Aboud, Christine M McDonald, Sabrina Moyo, Nasim Khavari, Karim Manji, Rodrick Kisenge, Wafaie Fawzi, Mark Kellogg, Hao Quang Tran, Gibson Kibiki, Jean Gratz, Jie Liu, Andrew Gewirtz, Eric Houpt, Christopher Duggan
OBJECTIVE: Diarrheal diseases are a leading cause of morbidity and mortality worldwide, but the etiology of diarrhea and its relationship to nutritional outcomes in resource-limited settings is poorly defined. We sought to determine the etiology of community-acquired diarrhea in Tanzanian infants, and to assess the association with anthropometrics and novel intestinal biomarkers. METHODS: A convenience sample of infants in a trial of zinc and/or multivitamin supplementation in Tanzania was selected...
June 24, 2016: Journal of Pediatric Gastroenterology and Nutrition
David J A Goldsmith
Evidence for the usefulness of using vitamin D to treat 'renal bone disease' is now nearly six decades old. In regular clinical practice, however, it is more like three decades, at most, that we have routinely been using vitamin D to try to prevent, or reverse, the impact of hyperparathyroidism on the skeleton of patients with chronic kidney disease (CKD). The practice has been in the main to use high doses of synthetic vitamin D compounds, not naturally occurring ones. However, the pharmacological impacts of the different vitamin D species and of their different modes, and styles of administration cannot be assumed to be uniform across the spectrum...
May 2016: Nephrology, Dialysis, Transplantation
Lindsey M Locks, Karim P Manji, Christine M McDonald, Roland Kupka, Rodrick Kisenge, Said Aboud, Molin Wang, Wafaie W Fawzi, Christopher P Duggan
BACKGROUND: Poor child growth increases risks of mortality and morbidity. Micronutrient supplements have the potential to improve child growth. OBJECTIVE: We assessed the effect of daily zinc, multivitamin (vitamins C, E, and B-complex), and zinc and multivitamin (Zn+MV) supplementation on growth in infants in Tanzania. DESIGN: In this randomized, 2 × 2 factorial, double-blind trial, 2400 infants were randomly assigned to receive zinc, multivitamins, Zn+MVs, or a placebo at 6 wk of age and were followed up for 18 mo with monthly growth measurements...
March 2016: American Journal of Clinical Nutrition
Kornelia Tomaszewska, Andrzej Klejewska, Ewelina Kostecka
The usage of multivitamin supplements for expectant mothers ought to always consult with a physician responsible for an expectant mother. Dietary supplements ought to be good chose to individual needs so that it can in an optimal way aid the health of an expectant mother and the progress of baby. The specialist literature and my ones researches show that a supplementary diet with multivitamin supplements and preparations with a folic acid in pregnancy can affect the mass of a neonate and increaser it. One should considers the implementation of multivitamin supplements by women from a risk group of the disorder development of an embryo...
2015: Przegla̧d Lekarski
Bhageeradh H Mulpur, L Burt Nabors, Reid C Thompson, Jeffrey J Olson, Renato V LaRocca, Zachary Thompson, Kathleen M Egan
BACKGROUND: Complementary therapy (CAM) is common in cancer patients. We undertook this study to assess the association of complementary therapy usage with mortality in glioblastoma (GBM) patients. METHODS: The analysis was based on 470 patients. Information on current use of CAM was collected in structured interviews conducted a median of 6 weeks following GBM diagnosis. Proportional hazards regression was used to estimate hazard ratios (HRs) for GBM-related death according to the use of individual supplements with multivariate adjustment for known prognostic factors including age, KPS, and extent of tumor resection (ESR)...
September 2015: Neuro-oncology Practice
Panxi Yu, Wenqi Diao, Qionglan Tang, Xuefeng Jiang
BACKGROUND: Pregnancies in hemodialysis patients are uncommon and difficult to study. Although the chance of a successful pregnancy and parturition in hemodialysis women has increased over the years, it still remains extremely low with a high maternal and fetal mortality and morbidity rate. CASE PRESENTATION: We reported a case of successful pregnancy and parturition in a 22-year-old Chinese female in uremic stage of chronic renal failure and undergoing maintenance hemodialysis (three sessions a week) for 6 years...
2015: BMC Pregnancy and Childbirth
David Guwatudde, Molin Wang, Amara E Ezeamama, Danstan Bagenda, Rachel Kyeyune, Henry Wamani, Yukari C Manabe, Wafaie W Fawzi
BACKGROUND: Efficacy trials investigating the effect of multivitamin (MV) supplementations among patients on Highly Active Antiretroviral Therapy (HAART) have so far been inconclusive. We conducted a randomized, double blind, placebo controlled trial to determine the effect of one recommended daily allowance (RDA) of MV supplementation on disease progression in patients initiating HAART. METHODS: Eligible subjects were randomized to receive placebo or MV supplementation including vitamins B-complex, C and E...
2015: BMC Infectious Diseases
Christine M McDonald, Karim P Manji, Rodrick Kisenge, Said Aboud, Donna Spiegelman, Wafaie W Fawzi, Christopher P Duggan
BACKGROUND: Although various micronutrient regimens have been shown to prevent and treat common infectious diseases in children, the effects of daily multivitamin (MV) and/or zinc supplementation have not been widely evaluated in young African infants. OBJECTIVE: The objective was to determine whether daily supplementation of HIV-unexposed Tanzanian infants with MVs or zinc reduces the risk of infectious morbidity compared with placebo. METHODS: In a 2 × 2 factorial, double-blind, randomized controlled trial, 2400 infants who were 6 wk of age and born to HIV-negative mothers in a low-malaria setting were randomly assigned to receive daily oral supplementation of MVs (vitamin B complex and vitamins C and E), zinc, zinc + MVs, or placebo for 18 mo...
September 2015: Journal of Nutrition
Eun Sil Lee
Health functional food is referred to a food prepared or processed from specific components or ingredients for functionality beneficial to the body through extraction, concentration, purification, blending and other methods. The demand for health functional foods is steadily increasing, and red ginseng is the most demanded food among women in the 50s, followed by multivitamin, omega-3, glucosamine and aloe. To date, there is insufficient evidence on the effect of red ginseng on exercise capacity, somatic symptom and cognitive performance in healthy individuals...
April 2015: Journal of Menopausal Medicine
Amy Kang, Sagar U Nigwekar, Vlado Perkovic, Satyarth Kulshrestha, Sophia Zoungas, Sankar D Navaneethan, Alan Cass, Martin P Gallagher, Toshiharu Ninomiya, Giovanni F M Strippoli, Meg J Jardine
BACKGROUND: Elevated homocysteine levels have been shown to be an independent risk factor for cardiovascular disease. However studies of homocysteine lowering in general and end-stage kidney disease (ESKD) populations have not demonstrated a reduction in cardiovascular event rates. Kidney transplant recipients have high homocysteine levels, high cardiovascular event rates and, unlike the ESKD population, may achieve normalisation of homocysteine levels with homocysteine lowering therapies...
2015: Cochrane Database of Systematic Reviews
Lukas Schwingshackl, Georg Hoffmann, Brian Buijsse, Tamara Mittag, Marta Stelmach-Mardas, Heiner Boeing, Marion Gottschald, Stefan Dietrich, Maria Arregui, Sofia Dias
BACKGROUND: In the Western world, dietary supplements are commonly used to prevent chronic diseases, mainly cardiovascular disease and cancer. However, there is inconsistent evidence on which dietary supplements actually lower risk of chronic disease, and some may even increase risk. We aim to evaluate the comparative safety and/or effectiveness of dietary supplements for the prevention of mortality (all-cause, cardiovascular, and cancer) and cardiovascular and cancer incidence in primary prevention trials...
2015: Systematic Reviews
Jia-Yi Dong, Hiroyasu Iso, Akihiko Kitamura, Akiko Tamakoshi
BACKGROUND AND PURPOSE: An effect of multivitamin supplement on stroke risk is uncertain. We aimed to examine the association between multivitamin use and risk of death from stroke and its subtypes. METHODS: A total of 72 180 Japanese men and women free from cardiovascular diseases and cancers at baseline in 1988 to 1990 were followed up until December 31, 2009. Lifestyles including multivitamin use were collected using self-administered questionnaires. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) of total stroke and its subtypes in relation to multivitamin use...
May 2015: Stroke; a Journal of Cerebral Circulation
Regan L Bailey, Tala H Fakhouri, Yikyung Park, Johanna T Dwyer, Paul R Thomas, Jaime J Gahche, Paige E Miller, Kevin W Dodd, Christopher T Sempos, David M Murray
BACKGROUND: Multivitamin-mineral (MVM) products are the most commonly used supplements in the United States, followed by multivitamin (MV) products. Two randomized clinical trials (RCTs) did not show an effect of MVMs or MVs on cardiovascular disease (CVD) mortality; however, no clinical trial data are available for women with MVM supplement use and CVD mortality. OBJECTIVE: The objective of this research was to examine the association between MVM and MV use and CVD-specific mortality among US adults without CVD...
March 2015: Journal of Nutrition
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