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https://www.readbyqxmd.com/read/28087509/use-of-both-serum-cystatin-c-and-creatinine-as-diagnostic-criteria-for-contrast-induced-acute-kidney-injury-and-its-clinical-implications
#1
Wei-Feng Zhang, Tuo Zhang, Ding Ding, Shi-Qun Sun, Xiao-Lei Wang, Shi-Chun Chu, Ling-Hong Shen, Ben He
BACKGROUND: Contrast-induced acute kidney injury (CI-AKI) was traditionally defined as an increase in serum creatinine (sCr) after contrast media exposure. Recently, serum cystatin C (sCyC) has been proposed as an alternative to detect acute changes in renal function. The clinical implications of combining sCyC and sCr to diagnose CI-AKI remain unknown. METHODS AND RESULTS: One thousand seventy-one consecutive patients undergoing coronary angiography/intervention were prospectively enrolled...
January 13, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28087383/stratified-premedication-strategy-for-the-prevention-of-contrast-media-hypersensitivity-in-high-risk-patients
#2
Suh-Young Lee, Min Suk Yang, Young-Hoon Choi, Chang Min Park, Heung-Woo Park, Sang Heon Cho, Hye-Ryun Kang
BACKGROUND: Although the severity of hypersensitivity reactions to iodinated contrast media varies, it is well correlated with the severity of recurrent reactions; however, prophylaxis protocols are not severity-stratified. OBJECTIVE: To assess the outcomes of tailored prophylaxis according to the severity of hypersensitivity reactions to iodinated contrast media. METHODS: Our premedication protocols were stratified based on the severity of previous reactions: (1) 4 mg of chlorpheniramine for mild reactions, (2) adding 40 mg of methylprednisolone for moderate reactions, and (3) adding multiple doses of 40 mg of methylprednisolone for severe index reactions...
January 10, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28086796/prophylaxis-of-post-erc-infectious-complications-in-patients-with-biliary-obstruction-by-adding-antimicrobial-agents-into-erc-contrast-media-a-single-center-retrospective-study
#3
Hella Wobser, Agnetha Gunesch, Frank Klebl
BACKGROUND: Patients with biliary obstruction are at high risk to develop septic complications after endoscopic retrograde cholangiography (ERC). We evaluated the benefits of local application of antimicrobial agents into ERC contrast media in preventing post-ERC infectious complications in a high-risk study population. METHODS: Patients undergoing ERC at our tertiary referral center were retrospectively included. Addition of vancomycin, gentamicin and fluconazol into ERC contrast media was evaluated in a case-control design...
January 13, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28077908/magnetic-resonance-imaging-of-a-case-of-central-neurocytoma
#4
Kreshnike Dedushi, Serbeze Kabashi, Mehmet Sahin Ugurel, Naser Ramadani, Sefedin Mucaj, Kamber Zeqiraj
BACKGROUND: The purpose of this study is to investigate the MRI features of central neurocytoma. CASE REPORT: A 45 year old man with 3 months of worsening daily headaches. These headaches were diffuse, lasted for several hours, and mostly occurred in the morning. She was initially diagnosed and treated for migraines but later he had epileptic attack and diplopia and neurolog recomaded MRI. METHODS: precontrast MRI; TSE/T2Wsequence in axial/coronal planes; 3D-Hi-resolution T1W sagittal; FLAIR/T2W axial; FLAIR/T2W and Flash/T2W oblique coronal plane (perpendicular to temporal lobes) GRE/T2W axial plane for detection of heme products...
December 2016: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28076391/assessing-sexual-dicromatism-the-importance-of-proper-parameterization-in-tetrachromatic-visual-models
#5
Pierre-Paul Bitton, Kevyn Janisse, Stéphanie M Doucet
Perceptual models of animal vision have greatly contributed to our understanding of animal-animal and plant-animal communication. The receptor-noise model of color contrasts has been central to this research as it quantifies the difference between two colors for any visual system of interest. However, if the properties of the visual system are unknown, assumptions regarding parameter values must be made, generally with unknown consequences. In this study, we conduct a sensitivity analysis of the receptor-noise model using avian visual system parameters to systematically investigate the influence of variation in light environment, photoreceptor sensitivities, photoreceptor densities, and light transmission properties of the ocular media and the oil droplets...
2017: PloS One
https://www.readbyqxmd.com/read/28075119/bubble-driven-detachment-of-bacteria-from-confined-microgeometries
#6
Sepideh Khodaparast, Minyoung Kevin Kim, Justin E Silpe, Howard A Stone
Moving air-liquid interfaces, for example, bubbles, play a significant role in the detachment and transport of colloids and microorganisms in confined systems as well as unsaturated porous media. Moreover, they can effectively prevent and/or postpone the development of mature biofilms on surfaces that are colonized by bacteria. Here we demonstrate the dynamics and quantify the effectiveness of this bubble-driven detachment process for the bacterial strain Staphylococcus aureus. We investigate the effects of interface velocity and geometrical factors through microfluidic experiments that mimic some of the confinement features of pore-scale geometries...
January 11, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28073563/genetic-and-toxinological-characterization-of-north-atlantic-strains-of-the-dinoflagellate-ostreopsis-and-allelopathic-interactions-with-toxic-and-non-toxic-species-from-the-genera-prorocentrum-coolia-and-gambierdiscus
#7
María García-Portela, Pilar Riobó, José Mariano Franco, Rosa Mª Bañuelos, Francisco Rodríguez
The genus Ostreopsis includes several toxic species that can develop blooms in benthic ecosystems, with potential harmful consequences for human health and marine invertebrates. Despite of this, little is known about the allelopathic interactions between these organisms and other co-occurring microalgae that exploit similar spatial and nutrient resources in benthic ecosystems. The aim of this study was to follow these interactions in cultures of two Ostreopsis ribotypes with different toxin profiles (O. cf...
December 2016: Harmful Algae
https://www.readbyqxmd.com/read/28072657/assessment-of-cochlea-endolymphatic-hydrops-using-3-d-flair-and-3-d-real-ir-sequence-in-guinea-pigs-via-3t-mri-after-intratympanic-gadolinium-a-histopathological-comparison
#8
Feng Wang, Huiying Lyu, Menglong Zhao, Yan Sha, Fang Zhang, Yushu Cheng, Wenhu Huang, Wenlin Tang, Youzhou Xie, Ping Lu
OBJECTIVE: We assessed whether the three-dimensional fluid-attenuated inversion-recovery (3-D FLAIR) and three-dimensional inversion-recovery with real reconstruction (3-D real IR) sequences can be used to detect cochlea endolymphatic hydrops (EHs) in guinea pigs using 3 Tesla magnetic resonance imaging (3T MRI). The results of 3-D real IR imaging were compared with histopathological outcomes. MATERIALS AND METHODS: Fourteen healthy men and women albino guinea pigs were used in this study...
January 9, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28072512/a-high-performance-hybrid-bismuth-carbon-nanotube-based-contrast-agent-for-x-ray-ct-imaging
#9
Mayra Hernández-Rivera, Ish Kumar, Stephen Y Cho, Benjamin Y Cheong, Merlyn X Pulikkathara, Sakineh E Moghaddam, Kenton Herbert Whitmire, Lon J Wilson
Carbon nanotubes (CNTs) have been used for a plethora of biomedical applications including their use as delivery vehi-cles for drugs, imaging agents, proteins, DNA, and other materials. Here we describe the synthesis and characterization of a new CNT-based contrast agent (CA) for X-ray computed tomography (CT) imaging. The CA is a hybrid material derived from ultra-short single-walled carbon nanotubes (20-80 nm long, US-tubes) and Bi(III) oxo-salicylate clusters with four Bi(III) ions per cluster (Bi4C). The element bismuth was chosen over iodine, which is the conventional element used for CT CAs in the clinic today, due to its high X-ray attenuation capability and its low toxicity, which make bismuth a more promising element for new CT CA design...
January 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28071899/near-ir-absorbing-gold-nanoframes-with-enhanced-physiological-stability-and-improved-biocompatibility-for-in-vivo-biomedical-applications
#10
Liying Wang, Yunching Chen, Hsin Yao Lin, Yung-Te Hou, Ling-Chu Yang, Aileen Y Sun, Jia-Yu Liu, Chien-Wen Chang, Dehui Wan
This paper describes the synthesis of near-infrared (NIR)-absorbing gold nanoframes (GNFs) and a systematic study comparing their physiological stability and biocompatibility with those of hollow Au-Ag nanoshells (GNSs), which have been used widely as photothermal agents in biomedical applications because of their localized surface plasmon resonance (LSPR) in the NIR region. The GNFs were synthesized in three steps: galvanic replacement, Au deposition, and Ag dealloying, using silver nanospheres (SNP) as the starting material...
January 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28071883/individually-stabilized-superparamagnetic-nanoparticles-with-controlled-shell-and-size-leading-to-exceptional-stealth-properties-and-high-relaxivities
#11
Andrea Lassenberger, Andrea Scheberl, Andreas Stadlbauer, Alexander Stiglbauer, Thomas Helbich, Erik Reimhult
Superparamagnetic iron oxide nanoparticles (SPION) have received immense interest for biomedical applications, with the earliest first clinical application as negative constrast agent in being for magnetic resonance imaging (MRI). However, the first generation MRI contrast agents with dextran-enwrapped, polydisperse, iron oxide nanoparticle clusters are limited to imaging of liver and spleen; this is related to their poor colloidal stability in biological media and inability to evade clearance by the reticuloendothelial system...
January 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28068907/hospitalized-care-for-mdr-tb-in-port-harcourt-nigeria-a-qualitative-study
#12
Kingsley Lezor Bieh, Ralf Weigel, Helen Smith
BACKGROUND: In Nigeria multidrug-resistant tuberculosis (MDR-TB) is prevalent in 2.9% of new TB cases and 14% of retreatment cases, and the country is one of 27 with high disease burden globally. Patients are admitted and confined to one of ten MDR-TB treatment facilities throughout the initial 8 months of treatment. The perspectives of MDR-TB patients shared on social media and in academic research and those of providers are limited to experiences of home-based care. In this study we explored the views of hospitalised MDR-TB patients and providers in one treatment facility in Nigeria, and describe how their experiences are linked to accessibility of care and support services, in line with international goals...
January 10, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28068764/topochemical-azide-alkyne-cycloaddition-reaction-in-gels-size-tunable-synthesis-of-triazole-linked-polypeptides
#13
Baiju P Krishnan, Kana M Sureshan
Though topochemical reactions are attractive, the difficulty associated with crystallization such as low yield, unsuitability for large scale synthesis etc warranted the exploitation of other self-assembled media for topochemical reactions. We synthesized a dipeptide gelator decorated with azide and alkyne at its termini, N3-Ala-Val-NHCH2-C≡CH, which is designed to self-assemble through intermolecular hydrogen bonds to β-sheets thereby placing the azide and alkyne motifs at proximity. As anticipated, this peptide forms gels in organic solvents and water via hydrogen-bonded β-sheet assembly as evidenced from IR spectroscopy and PXRD profiling...
January 10, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28068294/canine-olfaction-as-an-alternative-to-analytical-instruments-for-disease-diagnosis-understanding-dog-personality-to-achieve-reproducible-results
#14
Klaus Hackner, Joachim Pleil
Recent literature has touted the use of canine olfaction as a diagnostic tool for identifying pre-clinical disease status, especially cancer and infection from biological media samples. Studies have shown a wide range of outcomes, ranging from almost perfect discrimination, all the way to essentially random results. This disparity is not likely to be a detection issue; dogs have been shown to have extremely sensitive noses as proven by their use for tracking, bomb detection and search and rescue. However, in contrast to analytical instruments, dogs are subject to boredom, fatigue, hunger and external distractions...
January 9, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28068070/polymer-nanocomposites-with-cellulose-nanocrystals-featuring-adaptive-surface-groups
#15
Jens Christoph Natterodt, Janak Sapkota, E Johan Foster, Christoph Weder
Cellulose nanocrystals (CNCs) are mechanically rigid, toxicologically benign, fiber-like nanoparticles. They can easily be extracted from renewable bio-sources and have attracted significant interest as reinforcing fillers in polymers. We here report the modification of CNCs with the 2-ureido-4[1H]pyrimidinone (UPy) motif as an adaptive compatibilizer, which permits the dispersion of UPy-modified CNCs in nonpolar as well as polar media. In toluene, the UPy motifs appear to form intra-CNC dimers, so that the particles are somewhat hydrophobized and well-dispersible in this nonpolar solvent...
January 9, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28067199/ct-in-patients-with-tricuspid-regurgitation-prior-to-transcatheter-valve-repair-dynamic-analysis-of-the-annulus-with-an-individually-tailored-contrast-media-protocol
#16
Ricarda Hinzpeter, Matthias Eberhard, Philipp Burghard, Felix C Tanner, Maurizio Taramasso, Robert Manka, Gudrun Feuchtner, Francesco Maisano, Hatem Alkadhi
AIMS: To introduce a contrast media (CM)-protocol for the dynamic visualization of the tricuspid valve (TV) and tricuspid annulus (TA) with CT. METHODS AND RESULTS: Fifteen patients with no cardiac abnormalities (=controls), 15 patients with functional tricuspid regurgitation (FTR) <3+ and 13 patients with FTR ≥3+ underwent a dedicated cardiac CT protocol. Using an advanced visualization, segmentation and analysis software, the annular area, entire annular circumference, its three parts, and annular diameters were measured by two independent, blinded readers...
January 10, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28066679/image-guided-techniques-for-localizing-pulmonary-nodules-in-thoracoscopic-surgery
#17
REVIEW
Mong-Wei Lin, Jin-Shing Chen
Low-dose computed tomography (LDCT) screening has increased the detection rate for small pulmonary nodules with ground-glass opacity (GGO) in the peripheral lung parenchyma. Minimally invasive thoracoscopic surgery for these lung nodules is challenging for thoracic surgeons, and image-guided preoperative localization is mandatory for their successful resection. Image-guided localization methods primarily include two imaging tools: computed tomography (CT) and bronchoscopy. These different methods may use different localized materials, including hookwires, dyes, microcoils, fiducial markers, contrast media, and radiotracers...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28065276/using-imaging-as-a-biomarker-for-asthma
#18
REVIEW
Abhaya Trivedi, Chase Hall, Eric A Hoffman, Jason C Woods, David S Gierada, Mario Castro
There have been significant advancements in the various imaging techniques being used for the evaluation of asthmatic patients, both from a clinical and research perspective. Imaging characteristics can be used to identify specific asthmatic phenotypes and provide a more detailed understanding of endotypes contributing to the pathophysiology of the disease. Computed tomography, magnetic resonance imaging, and positron emission tomography can be used to assess pulmonary structure and function. It has been shown that specific airway and lung density measurements using computed tomography correlate with clinical parameters, including severity of disease and pathology, but also provide unique phenotypes...
January 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28059565/social-media-campaign-effects-moderating-role-of-social-capital-in-an-anti-smoking-campaign
#19
Kang Namkoong, Seungahn Nah, Stephanie K Van Stee, Rachael A Record
This study examined the effects of an anti-smoking campaign that employs a crowdsourcing method with a social networking service. Drawing upon social capital scholarship and the expression effect research paradigm in eHealth systems, the study also investigated the roles of social trust and community life satisfaction in the social media campaign that has a specific geographical boundary. To that end, we conducted an experiment using a two-group pretest-posttest design. We randomly assigned 201 participants to two conditions: "campaign message reception only" as a control group and "message reception and expression" as a treatment group in which participants fully engaged in the campaign process by sharing their own campaign ideas with other participants...
January 6, 2017: Health Communication
https://www.readbyqxmd.com/read/28059514/myelography-iodinated-contrast-media-ii-conformational-versatility-of-iopamidol-in-the-solid-state
#20
Barbara Bellich, Silvia Di Fonzo, Letizia Tavagnacco, Marco Paolantoni, Claudio Masciovecchio, Federica Bertolotti, Giovanna Giannini, Rita De Zorzi, Silvano Geremia, Alessandro Maiocchi, Fulvio Uggeri, Norberto Masciocchi, Attilio Cesàro
The phenomenon of polymorphism is of great relevance in pharmaceutics, since different polymorphs have different physico-chemical properties, e.g. solubility, hence, bioavailability. Coupling diffractometric and spectroscopic experiments with thermodynamic analysis and computational work opens to a methodological approach which provides information on both structure and dynamics in the solid as well as in solution. The present work reports on the conformational changes in crystalline iopamidol, which is characterized by atropisomerism, a phenomenon that influences both the solution properties and the distinct crystal phases...
January 6, 2017: Molecular Pharmaceutics
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