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https://www.readbyqxmd.com/read/28448412/optimizing-contrast-media-injection-protocols-in-computed-tomography-angiography-at-different-tube-voltages-evaluation-in-a-circulation-phantom
#1
Damiano Caruso, Marwen Eid, U Joseph Schoepf, Domenico De Santis, Akos Varga-Szemes, Stefanie Mangold, Christian Canstein, Virginia W Lesslie, Stephen R Fuller, B Devon Ball, Andrea Laghi, Carlo N De Cecco
OBJECTIVES: The aim of this study was to investigate the minimum iodine delivery rate (IDR) and contrast media (CM) volume required for diagnostic contrast enhancement of 350 HU (Hounsfield units) in the ascending aorta at different kV settings. METHODS: Dynamic computed tomography acquisitions from 70 to 150 kV were performed in a circulation phantom. First, injections with IDR ranging from 0.1 to 2.0 g I/s were tested for each kV. In the second part, the IDR was held constant, whereas the CM volume was reduced from 50 to 10 mL...
April 26, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28445910/influence-of-contrast-media-on-bone-mineral-density-bmd-measurements-from-routine-contrast-enhanced-mdct-datasets-using-a-phantom-less-bmd-measurement-tool
#2
Andrea Toelly, Constanze Bardach, Michael Weber, Rui Gong, Yanbo Lai, Pei Wang, Yulin Guo, Jan Kirschke, Thomas Baum, Michael Gruber
Aim To evaluate the differences in phantom-less bone mineral density (BMD) measurements in contrast-enhanced routine MDCT scans at different contrast phases, and to develop an algorithm for calculating a reliable BMD value. Materials and Methods 112 postmenopausal women from the age of 40 to 77 years (mean age: 57.31 years; SD 9.61) who underwent a clinically indicated MDCT scan, consisting of an unenhanced, an arterial, and a venous phase, were included. A retrospective analysis of the BMD values of the Th12 to L4 vertebrae in each phase was performed using a commercially available phantom-less measurement tool...
April 26, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28443894/taste-and-smell-in-aquatic-and-terrestrial-environments
#3
REVIEW
E Mollo, M J Garson, G Polese, P Amodeo, M T Ghiselin
Covering: up to 2017The review summarizes results up to 2017 on chemosensory cues occurring in both aquatic and terrestrial environments. The chemicals are grouped by their physicochemical properties to compare their potential mobility in the different media. In contrast to what is widely asserted in the literature, the report emphasizes that living organisms encounter and sense molecules of various degrees of solubility and volatility both on land and in aquatic environments. The picture that emerges from the review suggests a substantial revision of the traditional definitions of the chemical senses based on their spatial range, which is currently orienting the literature on chemosensory signaling, in favor of a new vision based on the natural products that are the actual mediators of the chemosensory perceptions...
April 26, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28443376/remote-ischemic-conditioning-and-renal-protection
#4
Georgios Giannopoulos, Dimitrios A Vrachatis, Vasiliki Panagopoulou, Manolis Vavuranakis, Michael W Cleman, Spyridon Deftereos
Over the course of the last 2 decades, the concept of remote ischemic conditioning (RIC) has attracted considerable research interest, because RIC, in most of its embodiments offers an inexpensive way of protecting tissues against ischemic damage inflicted by a number of medical conditions or procedures. Acute kidney injury (AKI) is a common side effect in the context of various medical procedures, and RIC has been suggested as a means of reducing its incidence. Outcomes regarding kidney function have been reported in numerous studies that evaluated the effects of RIC in a variety of settings (eg, cardiac surgery, interventions requiring intravenous administration of contrast media)...
January 1, 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28439760/prognostic-study-of-cardiac-events-in-japanese-patients-with-chronic-kidney-disease-using-ecg-gated-myocardial-perfusion-imaging-final-3-year-report-of-the-j-access-3-study
#5
Satoko Nakamura, Yuhei Kawano, Kenichi Nakajima, Hiroki Hase, Nobuhiko Joki, Tsuguru Hatta, Shigeyuki Nishimura, Masao Moroi, Susumu Nakagawa, Tokuo Kasai, Hideo Kusuoka, Yasuchika Takeishi, Mitsuru Momose, Kazuya Takehana, Mamoru Nanasato, Syunichi Yoda, Hidetaka Nishina, Naoya Matsumoto, Tsunehiko Nishimura
BACKGROUND: Myocardial perfusion imaging (MPI) is considered useful for risk stratification among patients with chronic kidney disease (CKD), without renal deterioration by contrast media. METHODS AND RESULTS: The Japanese Assessment of Cardiac Events and Survival Study by Quantitative Gated SPECT (J-ACCESS 3) is a multicenter, prospective cohort study investigating the ability of MPI to predict cardiac events in 529 CKD patients without a definitive coronary artery disease...
April 24, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28438671/alkaline-ph-induces-irr-mediated-phosphorylation-of-irs-1-and-actin-cytoskeleton-remodeling-in-a-pancreatic-beta-cell-line
#6
Igor E Deyev, Nadezhda V Popova, Oxana V Serova, Svetlana V Zhenilo, Marì Regoli, Eugenio Bertelli, Alexander G Petrenko
Secretion of mildly alkaline (pH 8.0-8.5) juice to intestines is one of the key functions of the pancreas. Recent reports indicate that the pancreatic duct system containing the alkaline juice may adjoin the endocrine cells of pancreatic islets. We have previously identified the insulin receptor-related receptor (IRR) that is expressed in islets as a sensor of mildly alkaline extracellular media. In this study, we show that those islet cells that are in contact with the excretory ducts are also IRR-expressing cells...
April 21, 2017: Biochimie
https://www.readbyqxmd.com/read/28438636/identification-of-chemotaxis-operon-cheyza-and-chea-gene-expression-under-stressful-conditions-in-piscirickettsia-salmonis
#7
Romina Albornoz, Karla Valenzuela, Juan P Pontigo, Patricio Sánchez, Pamela Ruiz, Ruben Avendaño-Herrera, Alex Romero, Cristian Oliver, Alejandro Yáñez
Piscirickettsia salmonis is the etiological agent of piscirickettsiosis, which, as the main systemic disease in the Chilean salmon industry, causes significant economic losses. This bacterium can produce biofilm as a persistence and survival strategy in adverse conditions. In other bacteria, cheA is a key gene for modulating the onset of bacterial chemotaxis, as well as having a secondary role in biofilm production. Notwithstanding this association, the potential relationships between biofilm formation and genes involved in P...
April 21, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28437011/noise-reduction-and-functional-maps-image-quality-improvement-in-dynamic-ct-perfusion-using-a-new-k-means-clustering-guided-bilateral-filter-kmgb
#8
Francesco Pisana, Thomas Henzler, Stefan Schönberg, Ernst Klotz, Bernhard Schmidt, Marc Kachelrieß
PURPOSE: Dynamic CT perfusion (CTP) consists in repeated acquisitions of the same volume in different time steps, slightly before, during and slightly afterwards the injection of contrast media. Important functional information can be derived for each voxel, which reflect the local hemodynamic properties and hence the metabolism of the tissue. Different approaches are being investigated to exploit data redundancy and prior knowledge for noise reduction of such datasets, ranging from iterative reconstruction schemes to high dimensional filters...
April 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/28434976/compartmentalized-microfluidic-perfusion-system-to-culture-human-induced-pluripotent-stem-cell-aggregates
#9
Yuki Kondo, Koji Hattori, Shota Tashiro, Eri Nakatani, Ryosuke Yoshimitsu, Taku Satoh, Shinji Sugiura, Toshiyuki Kanamori, Kiyoshi Ohnuma
Microfluidic perfusion systems enable small-volume cell cultures under precisely controlled microenvironments, and are typically developed for cell-based high-throughput screening. However, most such systems are designed to manipulate dissociated single cells, not cell aggregates, and are thus unsuitable to induce differentiation in human induced pluripotent stem cells (hiPSCs), which is conventionally achieved by using cell aggregates to increase cell-cell interactions. We have now developed a compartmentalized microfluidic perfusion system with large flow channels to load, culture, and observe cell aggregates...
April 20, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28431582/social-media-engagement-analysis-of-u-s-federal-health-agencies-on-facebook
#10
Sanmitra Bhattacharya, Padmini Srinivasan, Philip Polgreen
BACKGROUND: It is becoming increasingly common for individuals and organizations to use social media platforms such as Facebook. These are being used for a wide variety of purposes including disseminating, discussing and seeking health related information. U.S. Federal health agencies are leveraging these platforms to 'engage' social media users to read, spread, promote and encourage health related discussions. However, different agencies and their communications get varying levels of engagement...
April 21, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28431078/effect-of-threonine-on-secretory-immune-system-using-a-chicken-intestinal-ex%C3%A2-vivo-model-with-lipopolysaccharide-challenge
#11
Q Zhang, X Chen, S D Eicher, K M Ajuwon, T J Applegate
Secretory IgA (sIgA) and its transcytosis receptor, polymeric immunoglobulin receptor (pIgR), along with mucus, form the first lines of intestinal defense. Threonine (Thr) is a major component of intestinal mucins and IgA, which are highly secreted under lipopolysaccharide (LPS) induced inflammation. In the current study, the effect of Thr on the secretory immune system was determined in an ex vivo chicken ileal explant model. Results showed that a 2-hour Thr-deprivation of culture medium induced a compensatory increase in the mRNA expression of interleukin-8 (IL-8), mucin 2 ( ), and IgA during LPS challenge, and this increase was suppressed with Thr addition to the media ( P  ≤ 0...
April 18, 2017: Poultry Science
https://www.readbyqxmd.com/read/28430781/an-unmodified-wobble-uridine-in-trnas-specific-for-glutamine-lysine-and-glutamic-acid-from-salmonella-enterica-serovar-typhimurium-results-in-nonviability-due-to-increased-missense-errors
#12
Kristina Nilsson, Gunilla Jäger, Glenn R Björk
In the wobble position of tRNAs specific for Gln, Lys, and Glu a universally conserved 5-methylene-2-thiouridine derivative (xm5s2U34, x denotes any of several chemical substituents and 34 denotes the wobble position) is present, which is 5-(carboxy)methylaminomethyl-2-thiouridine ((c)mnm5s2U34) in Bacteria and 5-methylcarboxymethyl-2-thiouridine (mcm5s2U34) in Eukarya. Here we show that mutants of the bacterium Salmonella enterica Serovar Typhimurium LT2 lacking either the s2- or the (c)mnm5-group of (c)mnm5s2U34 grow poorly especially at low temperature and do not grow at all at 15°C in both rich and glucose minimal media...
2017: PloS One
https://www.readbyqxmd.com/read/28429163/antimicrobial-susceptibility-of-bacterial-isolates-from-patients-presenting-with-ear-nose-and-throat-ent-infections-in-the-german-community-healthcare-setting
#13
B Olzowy, M Kresken, M Havel, D Hafner, B Körber-Irrgang
Empiric initial antibiotic therapy of bacterial infections is based primarily upon the susceptibility of the most common causative pathogens. The purpose of this study was to provide susceptibility data on six bacterial species known to cause ear, nose and throat (ENT) infections. A total of 1066 isolates collected during a nationwide laboratory-based surveillance study were analysed. All Streptococcus pyogenes isolates were penicillin (PEN)-susceptible, indicating that natural penicillins can still be recommended as the first-line treatment for group A streptococcal tonsillopharyngitis...
April 20, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28428469/verification-of-the-injection-pressure-reduction-effect-using-the-novel-indwelling-needle-for-contrast-enhanced-ct
#14
Daiki Watanabe, Masaaki Fukunaga, Hiroyuki Yamamoto
PURPOSE: The purpose of this study was to investigate the injection pressure reduction effect of the novel indwelling needle (Becton, Dickinson and Company). METHOD: We evaluated the period of 651 patients who underwent dynamic computed tomography. We compared the maximum injection pressure. The contrast medium was administered at 320, 350, and 370 mgI/ml. RESULT: The maximum injection pressure of the novel indwelling needle in 22 G was decreased 10% compared with SC5 in all contrast media...
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/28427815/the-swedish-radiological-environmental-protection-regulations-applied-in-a-review-of-a-license-application-for-a-geological-repository-for-spent-nuclear-fuel
#15
Pål Andersson, Karolina Stark, Shulan Xu, Maria Nordén, Björn Dverstorp
For the first time, a system for specific consideration of radiological environmental protection has been applied in a major license application in Sweden. In 2011 the Swedish Nuclear Fuel & Waste Management Co. (SKB) submitted a license application for construction of a geological repository for spent nuclear fuel at the Forsmark site. The license application is supported by a post-closure safety assessment, which in accordance with regulatory requirements includes an assessment of environmental consequences...
April 17, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28426215/five-and-six-coordinated-silver-i-complexes-derived-from-2-6-pyridyl-iminodiadamantanes-sustained-release-of-bioactive-silver-toward-bacterial-eradication
#16
Jorge Jimenez, Indranil Chakraborty, Anthony M Del Cid, Pradip K Mascharak
Silver(I) complexes of two designed tridentate ligands, namely, 2,6-(pyridyl)iminoditriazaadamantane (pydTAm) and 2,6-(pyridyl)iminodiadamantane (pydAm), have been synthesized and structurally characterized. [Ag(pydTAm)2](CF3SO3) (1), the hitherto unknown mer isomer of a silver(I) octahedral complex, crystallizes in a highly symmetric body-centered cubic I4̅3m space group. Quite in contrast, the Ag(I) center in the analogous [Ag(pydAm)2](CF3SO3) (2) complex resides in a trigonal-bipyramidal geometry and crystallizes in a triclinic P1̅ space group with two crystallographically independent molecules in the asymmetric unit...
April 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28425122/mean-intercept-anisotropy-analysis-of-porous-media-ii-conceptual-shortcomings-of-the-mil-tensor-definition-and-minkowski-tensors-as-an-alternative
#17
Michael A Klatt, Gerd E Schröder-Turk, Klaus Mecke
PURPOSE: Structure-property relations, which relate the shape of the microstructure to physical properties such as transport or mechanical properties, need sensitive measures of structure. What are suitable fabric tensors to quantify the shape of anisotropic heterogeneous materials? The mean intercept length is among the most commonly used characteristics of anisotropy in porous media, e. g., of trabecular bone in medical physics. Yet, in this series of two papers we demonstrate that it has conceptual shortcomings that limit the validity of its results...
April 20, 2017: Medical Physics
https://www.readbyqxmd.com/read/28424042/the-effect-of-a-new-angiographic-imaging-technology-on-radiation-dose-in-visceral-embolization-procedures
#18
Frederic Baumann, Constantino Peña, Roman Kloeckner, Barry T Katzen, Ripal Gandhi, James B Benenati
PURPOSE: To evaluate the impact of a new angiographic imaging technology on radiation dose during visceral embolization procedures involving both fluoroscopy and digital subtraction angiography. MATERIAL AND METHODS: A retrospective analysis from a single-center consecutive series of patients was performed comparing 2 angiographic imaging systems. The AlluraClarity (CIQ; Philips Healthcare, Best, the Netherlands) was used in 100 patients (n = 59 male, mean age: 70...
May 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28422486/stable-nanocomposite-based-on-pegylated-and-silver-nanoparticles-loaded-graphene-oxide-for-long-term-antibacterial-activity
#19
Rongtao Zhao, Min Lv, Yang Li, Mingxuan Sun, Wen Kong, Lihua Wang, Shiping Song, Chunhai Fan, Leili Jia, Shaofu Qiu, Yansong Sun, Hongbin Song, Rongzhang Hao
The increasing occurrence of antibiotic-resistant pathogens, especially superbugs, is compromising the efficacy of traditional antibiotics. Silver nanoparticles (AgNPs) loaded graphene oxide (GO) nanocomposite (GO-Ag) has drawn great interest as a promising alternative antibacterial material. However, GO-Ag nanocomposite often irreversibly aggregates in physiological solutions, severely influencing its antibacterial capacity and practical application. Herein, a PEGylated and AgNPs loaded GO nanocomposite (GO-PEG-Ag) is synthesized through a facile approach utilizing microwave irradiation, while avoiding extra reducing agents...
April 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28419803/hydropersulfides-h-atom-transfer-agents-par-excellence
#20
Jean-Philippe R Chauvin, Markus Griesser, Derek A Pratt
Hydropersulfides (RSSH) are formed endogenously via the reaction of the gaseous biotransmitter hydrogen sulfide (H2S) and disulfides (RSSR) and/or sulfenic acids (RSOH). RSSH have been investigated for their ability to store H2S in vivo and as a line of defence against oxidative stress, from which it is clear that RSSH are much more reactive to two-electron oxidants than thiols. Herein we describe the results of our investigations into the H-atom transfer chemistry of RSSH, contrasting it with the well-known H-atom transfer chemistry of thiols...
April 18, 2017: Journal of the American Chemical Society
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