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https://www.readbyqxmd.com/read/27929271/hormone-therapy-and-other-treatments-for-symptoms-of-menopause
#1
D Ashley Hill, Mark Crider, Susan R Hill
The results of large clinical trials have led physicians and patients to question the safety of hormone therapy for menopause. In the past, physicians prescribed hormone therapy to improve overall health and prevent cardiac disease, as well as for symptoms of menopause. Combined estrogen/progestogen therapy, but not estrogen alone, increases the risk of breast cancer when used for more than three to five years. Therefore, in women with a uterus, it is recommended that physicians prescribe combination therapy only to treat menopausal symptoms such as vasomotor symptoms (hot flashes) and vaginal atrophy, using the smallest effective dosage for the shortest possible duration...
December 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27928699/estimating-the-oncotypedx-score-validation-of-an-inexpensive-estimation-tool
#2
Anne A Eaton, Catherine E Pesce, James O Murphy, Michelle M Stempel, Sujata M Patil, Edi Brogi, Clifford A Hudis, Mahmoud El-Tamer
BACKGROUND: OncotypeDX, a multi-gene expression assay, has been incorporated into clinical practice as a prognostic and predictive tool. However, its use in resource-constrained international healthcare systems is limited. Here we develop and validate a simplified model using clinicopathologic criteria to predict OncotypeDX score. METHODS: Patients with estrogen receptor (ER) and/or progesterone receptor (PR)-positive and HER2-negative invasive ductal carcinoma for whom the OncotypeDX test was successfully performed between 09/2008 and 12/2011 were retrospectively identified...
December 7, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27926517/suberoylanilide-hydroxamic-acid-induced-specific-epigenetic-regulation-controls-leptin-induced-proliferation-of-breast-cancer-cell-lines
#3
Xiuyan Feng, Han Han, Dan Zou, Jiaming Zhou, Weiqiang Zhou
Breast cancer is one of the most common malignancies among women in the world, investigating the characteristics and special transduction pathways is important for better understanding breast development and tumorigenesis. Leptin, a peptide hormone secreted from white adipocytes, may be an independent risk factor for breast cancer.Here, we treated suberoylanilide hydroxamic acid (SAHA) on Leptin-induced cell proliferation and invasion in the estrogen-receptor-positive breast cancer cell line MCF-7 and triple-negative breast cancer cell line MDA-MB-231...
December 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27925180/a-16-yin-yang-gene-expression-ratio-signature-for-er-node-breast-cancer
#4
Wayne Xu, Gaofeng Jia, Nianguang Cai, Shujun Huang, James R Davie, Marshall Pitz, Shantanu Banerji, Leigh Murphy
Breast cancer is one of the leading causes of cancer death in women. It is a complex and heterogeneous disease with different clinical outcomes. Stratifying patients into subgroups with different outcomes could help guide clinical decision making. In this study, we used two opposing groups of genes, Yin and Yang, to develop a prognostic expression ratio signature. Using the METABRIC cohort we identified a16-gene signature capable of stratifying breast cancer patients into four risk levels with intention that low-risk patients would not undergo adjuvant systemic therapy, intermediate-low-risk patients will be treated with hormonal therapy only, and intermediate-high- and high-risk groups will be treated by chemotherapy in addition to the hormonal therapy...
December 7, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27924832/impaired-receptivity-and-decidualization-in-dhea-induced-pcos-mice
#5
Shu-Yun Li, Zhuo Song, Min-Jie Song, Jia-Wen Qin, Meng-Long Zhao, Zeng-Ming Yang
Polycystic ovary syndrome (PCOS), a complex endocrine disorder, is a leading cause of female infertility. An obvious reason for infertility in PCOS women is anovulation. However, success rate with high quality embryos selected by assisted reproduction techniques in PCOS patients still remain low with a high rate of early clinical pregnancy loss, suggesting a problem in uterine receptivity. Using a dehydroepiandrosterone-induced mouse model of PCOS, some potential causes of decreased fertility in PCOS patients were explored...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27923582/high-mrna-levels-of-17%C3%AE-hydroxysteroid-dehydrogenase-type-1-correlate-with-poor-prognosis-in-endometrial-cancer
#6
Karlijn M C Cornel, Camilla Krakstad, Bert Delvoux, Sofia Xanthoulea, Balazs Jori, Marlies Y Bongers, Gonda Konings, Loes F S Kooreman, Roy Fpm Kruitwagen, Helga B Salvesen, Andrea Romano
Most endometrial cancers (ECs) are diagnosed at an early stage and have a good prognosis. However, 20-30% develop recurrence and have poor survival. Recurrence-risk prediction at diagnosis is hampered by the scarcity of prognostic markers. Most ECs are estrogen related, and recent studies show that estrogen exposure in EC is controlled intracrinally. We aim at assessing any association between patient prognosis and the pathways controlling the intracrine estrogen generation in EC: Patients with high mRNA of HSD17B1 had a poorer prognosis compared with those with low levels...
December 3, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27908213/determinants-of-low-bone-mineral-density-in-premenopausal-polycystic-ovary-syndrome-patients
#7
Cihan Karadağ, Tevfik Yoldemir, Dilek Gogas Yavuz
OBJECTIVE: The aim of this study was to evaluate the bone mineral density (BMD) values and to determine the associations between BMD and insulin sensitivity, hyperandrogenemia, body mass index (BMI), and sex hormones in premenopausal polycystic ovary syndrome (PCOS) patients. METHODS: A hundred and three women with PCOS and sixty age- and BMI-matched healthy control women were enrolled to this cross-sectional study. Serum androgen and estradiol (E2) levels were measured...
December 2, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27900987/effect-of-half-dose-and-standard-dose-conjugated-equine-estrogens-combined-with-natural-progesterone-or-dydrogesterone-on-components-of-metabolic-syndrome-in-healthy-postmenopausal-women-a-randomized-controlled-trial
#8
Wei Xue, Yan Deng, Yan-Fang Wang, Ai-Jun Sun
BACKGROUND: Menopausal hormone therapy (MHT) has been proven to have beneficial effects on several components of metabolic syndrome. However, the effects vary according to different regimens, dosages, and duration of MHT. The aim of the study was to evaluate the effect of standard-dose 0.625 mg conjugated equine estrogen (CEE) and half-dose 0.3 mg CEE daily with different progestogens in a continuous sequential regimen on postmenopausal metabolic parameters in generally healthy postmenopausal women...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27900490/discordance-between-original-and-central-laboratories-in-er-and-her2-results-in-a-diverse-population-based-sample
#9
Jennifer J Griggs, Ann S Hamilton, Kendra L Schwartz, Weiqiang Zhao, Paul H Abrahamse, Dafydd G Thomas, Julie M Jorns, Rachel Jewell, Maria E Sibug Saber, Reina Haque, Steven J Katz
PURPOSE: To investigate the discordance between original and central laboratories in estrogen receptor (ER) status, in tumors originally deemed to be ER-negative, and in HER2 status in a diverse population-based sample. METHODS: In a follow-up study of 1785 women with Stage I-III breast cancer diagnosed between 2005 and 2007 in the Detroit and Los Angeles County SEER registry catchment areas, participants were asked to consent to reassessment of ER (in tumors originally deemed to be ER-negative) and HER2 status on archival tumor samples approximately four years after diagnosis...
November 29, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27900250/effect-of-tens-on-stimulation-of-saliva-in-postmenopausal-women-with-or-without-oral-dryness-an-interventional-study
#10
Aravinda Konidena, Dheeraj Sharma, Gagan Puri, Avani Dixit, Deepa Jatti, Rajesh Gupta
BACKGROUND: Decreased estrogen levels in postmenopausal women may cause an increase in oral symptoms including dry mouth, burning sensation of the mouth, and taste alterations. Management of salivary gland hypofunction by various modalities had been tried with variable results and associated side effects or discomfort. AIM: To evaluate the effects of transcutaneous electric nerve stimulation (TENS) on whole salivary flow rate in postmenopausal females with and without oral dryness...
November 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27899496/hormonal-contraception-and-risk-of-thromboembolism-in-women-with-diabetes
#11
Sarah H O'Brien, Terah Koch, Sara K Vesely, Eleanor Bimla Schwarz
OBJECTIVE: To investigate safety of hormonal contraception with regard to thromboembolic events in women with type 1 or 2 diabetes. RESEARCH DESIGN AND METHODS: We used data from 2002-2011 in Clinformatics Data Mart to identify women in the U.S., 14-44 years of age, with an ICD-9-CM code for diabetes and a prescription for a diabetic medication or device. We examined contraceptive claims and compared time to thromboembolism (venous thrombosis, stroke, or myocardial infarction) among women with diabetes dispensed hormonal contraception using a modification of Cox regression to control for age, smoking, obesity, hypertension, hyperlipidemia, diabetic complications, and history of cancer; we excluded data for 3 months after women gave birth...
November 29, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27898651/prevalence-and-correlates-of-vaginal-estrogenization-in-postmenopausal-women-in-the-united-states
#12
Stacy Tessler Lindau, Annie Dude, Natalia Gavrilova, Joscelyn N Hoffmann, L Philip Schumm, Martha K McClintock
OBJECTIVE: This work aims to establish current population-based vaginal estrogenization norms for postmenopausal US women. METHODS: Using a US national probability sample of 868 postmenopausal women ages 57 to 85 years (mean age 67.6 ± 0.3 y, 21.6 ± 0.5 y since menopause), we calculated the epithelial maturation value (MV) generated from self-collected vaginal specimens and compared findings with historical clinical data. Linear and logistic regressions were used to describe the relationship between vaginal estrogenization and sociodemographic, physical, gynecologic, and sexual characteristics...
November 28, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27897166/erratum-effects-of-low-dose-estrogen-therapy-on-the-vaginal-microbiomes-of-women-with-atrophic-vaginitis
#13
Jian Shen, Ning Song, Christopher J Williams, Celeste J Brown, Zheng Yan, Chen Xu, Larry J Forney
No abstract text is available yet for this article.
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27897127/effects-of-noise-exposure-on-the-auditory-function-of-ovariectomized-rats-with-estrogen-deficiency
#14
Xujun Hu, Ying Wang, Chi Chuen Lau
OBJECTIVE: The benefits of estrogen for the auditory function of women depend on a number of factors. In this study, we aimed to examine the impact of noise trauma on the auditory function of ovariectomized rats with estrogen deficiency. MATERIALS AND METHODS: Twenty-eight young, female Sprague-Dawley rats were assigned to three groups (OVX+N, OVX-N, Sham+N). Rats in the OVX+N group and the OVX-N group underwent bilateral ovariectomy (OVX); the OVX+N group alone was also exposed to white noise (N) of 115 dB SPL for 8 hours a day over 14 days...
November 28, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27881458/dosage-of-estradiol-bone-and-body-composition-in-turner-syndrome-a-5-year-randomized-controlled-clinical-trial
#15
Line Cleemann, Kirsten Holm, Hanne Kobbernagel, Bent Kristensen, Sven Oluf Skouby, Andreas Emil Kryger Jensen, Claus Hojbjerg Gravholt
OBJECTIVE: Reduced bone mineral density (BMD) is seen in Turner syndrome (TS) with an increased risk of fractures, and body composition is characterized by increased body fat and decreased lean body mass. To evaluate the effect of two different doses of oral 17ß-estradiol in young TS women on bone mineral density (BMD), biochemical markers of bone turnover, and body composition with the hypothesis of a positive effect of the higher dose. DESIGN: A double-blind 5-year randomized controlled clinical trial...
November 23, 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27879963/hypogonadism-and-non-alcoholic-fatty-liver-disease
#16
Gesthimani Mintziori, Pavlos Poulakos, Christos Tsametis, Dimitrios G Goulis
Non-alcoholic fatty liver disease (NAFLD) is more common in men than in women. Thus, it has been suggested that sex steroids do have a role in the development of NAFLD. The aim of the current paper is to illustrate the association between NAFLD and hypogonadism, by reviewing data derived from both human and animal studies. The prevalence of NAFLD is high in men with hypogonadism, including those with idiopathic hypogonadotropic hypogonadism (IHH), as well as in women in post- menopause, those under estrogen receptor antagonist treatment or women with Turner syndrome...
November 23, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27868084/the-association-between-bone-turnover-markers-and-kyphosis-in-community-dwelling-older-adults
#17
Corinne R McDaniels-Davidson, Donna Kritz-Silverstein, Mei-Hua Huang, Gail A Laughlin, Sarah Johnson, Jouko Haapalahti, Diane L Schneider, Elizabeth Barrett-Connor, Deborah M Kado
PURPOSE: Hyperkyphosis, accentuated curvature of the thoracic spine, is often attributed to osteoporosis, yet its underlying pathophysiology is not well understood. Bone turnover markers (BTM) reflect the dynamic process of bone formation and resorption. This study examined the association between serum BTM levels and kyphosis in community-dwelling older adults. METHODS: Between 2003 and 2006, 760 men and women in the Rancho Bernardo Study age 60 and older had blood drawn and kyphosis measured...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/27856968/estrogen-induced-monocytic-response-correlates-with-temporomandibular-disorder-pain-a-case-control-study
#18
M C Ribeiro-Dasilva, R B Fillingim, S M Wallet
Temporomandibular disorders (TMD) are a set of conditions characterized by pain and dysfunction in the temporomandibular joint and muscles of mastication. These pain conditions are associated with considerable morbidity, societal costs, and reduced quality of life. The prevalence varies between 4% and 10%, with females at higher risk, and a higher prevalence occurs during reproductive years. The increased prevalence of TMD in females and low prevalence in childhood reinforce that sex hormones, like estrogen, play an important, complex role in the pathophysiology of these disorders...
November 16, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27848887/metabolism-and-toxicological-implications-of-commonly-used-chemopreventive-drugs-against-breast-cancer-carcinogenesis
#19
Aliyu Muhammad, Mohammed Auwal Ibrahim, Ochuko Lucky Erukainure, Ibrahim Malami, Hadiza Sani, Hafsat Abdullahi Mohammed
BACKGROUND: Breast cancer has been reported to be among the frequently diagnosed cancer in women worldwide despite advances in early detection and treatment. Several drugs are currently used for chemoprevention as a result of a number of drawbacks associated with breast cancer therapy. AIM: This review focuses on the metabolism and toxicological implications of these drugs against breast cancer/carcinogenesis. METHODOLOGY: Relevant articles on the commonly used anti-breast cancer drugs (raloxifene, tamoxifen, anastrozole, letrozole and exemestane) used in chemoprevention were searched using the major scientific databases including Scopus, Embase, PubMed/ Medline, Sciencedirect and Google Scholar...
November 16, 2016: Current Drug Metabolism
https://www.readbyqxmd.com/read/27843626/tumour-and-cellular-distribution-of-activated-forms-of-pr-in-breast-cancers-a-novel-immunohistochemical-analysis-of-a-large-clinical-cohort
#20
Jacques Bonneterre, Jacques Bosq, Philippe Jamme, Alexander Valent, Erard M Gilles, Alexander A Zukiwski, Suzanne A W Fuqua, Carol A Lange, Joyce O'Shaughnessy
BACKGROUND: The progesterone receptor (PR) is expressed by ∼70% of early breast tumours and is implicated in the progression of breast cancer. In cancerous tissues PR may be activated in the absence of a ligand, or when ligand concentrations are very low, resulting in aberrantly activated PR (APR). The presence of APR may indicate that patients with breast cancer are more likely to respond to antiprogestins. The aims of this study were to describe and classify the histological subnuclear morphology of active and inactive PR in archival breast cancer samples...
2016: ESMO Open
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