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https://www.readbyqxmd.com/read/28323914/menopause-is-a-determinant-of-breast-aromatase-expression-and-its-associations-with-bmi-inflammation-and-systemic-markers
#1
Kristy A Brown, Neil M Iyengar, Xi Kathy Zhou, Ayca Gucalp, Kotha Subbaramaiah, Hanhan Wang, Dilip D Giri, Monica Morrow, Domenick J Falcone, Nils K Wendel, Lisle A Winston, Michael Pollak, Anneloor Dierickx, Clifford A Hudis, Andrew J Dannenberg
CONTEXT: Most estrogen-dependent breast cancers occur after menopause despite low levels of circulating estrogens. Breast expression of the estrogen-biosynthetic enzyme, aromatase, is proposed to drive breast cancer development after menopause. However, the effects of menopause on breast aromatase expression are unknown. OBJECTIVE: To determine the effect of menopause on breast aromatase expression in relation to body mass index (BMI), white adipose tissue inflammation (WATi) and systemic markers of metabolic dysfunction...
February 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323042/comparison-of-intravaginal-0-5-prasterone-0-3mg-conjugated-estrogens-and-10%C3%AE-g-estradiol-on-estrogen-related-symptoms-of-vulvovaginal-atrophy
#2
REVIEW
David F Archer, Fernand Labrie, Marlene Montesino, Céline Martel
The objective is to compare the effect of intravaginal dehydroepiandrosterone (DHEA, prasterone), conjugated equine estrogens (CEE) and estradiol (E2) on moderate to severe dyspareunia and/or vaginal dryness. In a review of available data, independent prospective, randomized, double-blind and placebo-controlled Phase III 12-week clinical trials involved daily administration of 6.5mg (0.50%) prasterone, daily (21days on/7days off) 0.3mg CEE, twice weekly 0.3mg CEE or 10 μg E2 daily for 2 weeks followed by twice weekly for 10 weeks...
March 17, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28293912/breast-cancer-subtype-distribution-is-different-in-normal-weight-overweight-and-obese-women
#3
Victoria Gershuni, Yun R Li, Austin D Williams, Alycia So, Laura Steel, Elena Carrigan, Julia Tchou
PURPOSE: Obesity is associated with tumor promoting pathways related to insulin resistance and chronic low-grade inflammation which have been linked to various disease states, including cancer. Many studies have focused on the relationship between obesity and increased estrogen production, which contributes to the pathogenesis of estrogen receptor-positive breast cancers. The link between obesity and other breast cancer subtypes, such as triple-negative breast cancer (TNBC) and Her2/neu+ (Her2+) breast cancer, is less clear...
March 14, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28292981/vaginal-heparan-sulfate-linked-to-neutrophil-dysfunction-in-the-acute-inflammatory-response-associated-with-experimental-vulvovaginal-candidiasis
#4
Junko Yano, Mairi C Noverr, Paul L Fidel
Despite acute inflammation by polymorphonuclear neutrophils (PMNs) during vulvovaginal candidiasis (VVC), clearance of Candida fails to occur. The purpose of this study was to uncover the mechanism of vaginal PMN dysfunction. Designs included assessing PMN migration, proinflammatory mediators, and tissue damage (by analysis of the activity of lactate dehydrogenase [LDH]) in mice susceptible (C3H/HeN-C57BL/6) or resistant (CD-1) to chronic VVC (CVVC-S or CVVC-R) and testing morphology-specific Candida albicans strains under conditions of preinduced PMN migration (CVVC-S mice) or PMN depletion (CVVC-R mice)...
March 14, 2017: MBio
https://www.readbyqxmd.com/read/28281363/the-evidence-base-for-hrt-what-can-we-believe
#5
REVIEW
R D Langer
Prior to the unexpected early termination of the Women's Health Initiative (WHI) trial of continuous conjugated equine estrogens (CEE) and medroxyprogesterone acetate (MPA), the prevailing view was that hormone replacement therapy (HRT) was a low-risk intervention with immediate value for symptom relief in recently menopausal women, and that it probably conferred long-term protection against the major chronic diseases that affect women after menopause. Rather than replicating prior studies, the WHI was designed to test whether the beneficial associations consistently seen in women starting HRT near menopause would be found in women well beyond menopause...
April 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28270171/brca1-expression-proliferative-and-apoptotic-activities-in-ovarian-epithelial-inclusions
#6
Yiying Wang, Yue Wang, Li Wei, Shuhui Hong, Miaoqing Zhao, Xi Zhang, Wenxin Zheng
BACKGROUND: The purpose of this study was to examine proliferative and apoptotic activity in relation with BRCA1 expression in ovarian epithelial inclusions (OEIs), the putative precursor lesions of ovarian epithelial cancer (OEC). METHODS: Benign ovaries from 95 patients were examined. Dual immunohistochemical staining for both BRCA1 and MIB-1 were performed to examine the relationship between BRCA1 and MIB-1 in OEI cells. Apoptotic activity was assessed on the parallel tissue sections by using TUNEL assay...
March 7, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28264438/association-of-hormone-receptor-expression-with-survival-in-ovarian-endometrioid-carcinoma-biological-validation-and-clinical-implications
#7
Peter Rambau, Linda E Kelemen, Helen Steed, May Lynn Quan, Prafull Ghatage, Martin Köbel
This paper aims to validate whether hormone receptor expression is associated with longer survival among women diagnosed with ovarian endometrioid carcinoma (EC), and whether it identifies patients with stage IC/II tumors with excellent outcome that could be spared from toxic chemotherapy. Expression of estrogen receptor (ER) and progesterone receptor (PR) was assessed on 182 EC samples represented on tissue microarrays using the Alberta Ovarian Tumor Type (AOVT) cohort. Statistical analyses were performed to test for associations with ovarian cancer specific survival...
February 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28260236/mediterranean-diet-adherence-and-risk-of-postmenopausal-breast-cancer-results-of-a-cohort-study-and-meta-analysis
#8
Piet A van den Brandt, Maya Schulpen
The Mediterranean Diet (MD) has been associated with reduced mortality and risk of cardiovascular diseases, but there is only limited evidence on cancer. We investigated the relationship between adherence to MD and risk of postmenopausal breast cancer (and estrogen/progesterone receptor subtypes, ER/PR). In the Netherlands Cohort Study, 62,573 women aged 55-69 years provided information on dietary and lifestyle habits in 1986. Follow-up for cancer incidence until 2007 (20.3 years) consisted of record linkages with the Netherlands Cancer Registry and the Dutch Pathology Registry PALGA...
March 5, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28257758/cognition-in-female-rats-after-blocking-conversion-of-androgens-to-estrogens
#9
George T Taylor, Francesca M Manzella, Jacob Huffman, Omar H Cabrera, Jessica Hoffman
Women and non-human females have surprisingly high levels of circulating testosterone, yet the effects of androgens on non-reproductive behaviors, including cognition, of females are not well characterized. The current project used an aromatase inhibitor, letrozole, to block conversion of androgens to estrogens. Adult female rats were ovariectomized and administered either vehicle only, testosterone propionate only (400μg/kg, TP only), letrozole only (1mg/kg, Letro only), or the combination of letrozole and testosterone (TP+Letro) over 4weeks...
March 12, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28253895/ezh2-protein-expression-in-normal-breast-epithelium-and-risk-of-breast-cancer-results-from-the-nurses-health-studies
#10
Francisco Beca, Kevin Kensler, Benjamin Glass, Stuart J Schnitt, Rulla M Tamimi, Andrew H Beck
BACKGROUND: Enhancer of zeste homolog 2 (EZH2) is a polycomb-group protein that is involved in stem cell renewal and carcinogenesis. In breast cancer, increased EZH2 expression is associated with aggressiveness and has been suggested to identify normal breast epithelium at increased risk of breast cancer development. However, the association between EZH2 expression in benign breast tissue and breast cancer risk has not previously been evaluated in a large prospective cohort. METHODS: We examined the association between EZH2 protein expression and subsequent breast cancer risk using logistic regression in a nested case-control study of benign breast disease (BBD) and breast cancer within the Nurses' Health Studies...
March 2, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28251065/interleukin-6-and-ratio-of-plasma-interleukin-6-interleukin-10-as-risk-factors-of-symptomatic-lumbar-osteoarthritis
#11
I Ketut Suyasa, I Ketut Siki Kawiyana, I Made Bakta, I Gde Raka Widiana
AIM: To determine the role of cartilage oligomeric matrix protein (COMP), interleukin (IL)-6, IL-10 and ratio of IL-6/IL-10 as risk factors of symptomatic lumbar osteoarthritis (OA) in postmenopausal women with estrogen deficiency. METHODS: Case-control study had been conducted in Sanglah General Hospital from October 2015 until March 2016. The blood samples were obtained and analyzed by enzyme-linked immunosorbent assay (ELISA). RESULTS: From 44 pairs of samples which divided into 44 samples as case group and 44 samples as control group showed that high level of COMP in estrogen deficiency postmenopausal women were not at risk (OR = 0...
February 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28251049/low-dose-bisphenol-a-exposure-a-seemingly-instigating-carcinogenic-effect-on-breast-cancer
#12
REVIEW
Zhe Wang, Huiyu Liu, Sijin Liu
Breast cancer is the fifth most common cause of cancer death in the world and the second most common fatal cancer in women. Epidemiological studies and clinical data have indicated that hormones, including estrogen, progesterone, and prolactin, play important roles in the initiation and progression of breast cancer. Bisphenol A (BPA) is one of the most commonly used and thoroughly studied endocrine disruptors. It can be released from consumer products and deposited in the environment, thus creating potential for human exposure through oral, inhaled, and dermal routes...
February 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28237088/low-long-chain-omega-3-fatty-acid-status-in-middle-aged-women
#13
Sandra Gellert, Jan Philipp Schuchardt, Andreas Hahn
INTRODUCTION: Long-chain (LC) omega-3 fatty acids (n-3 PUFAs) have beneficial effects on cardiovascular health and cognitive decline. Several studies have shown that the LC n-3 PUFA status in women in western countries is low. The aim of this study was to assess the LC n-3 PUFA status in middle-aged German women and to identify variables that might affect the status. MATERIAL AND METHODS: From the nationwide and cross-sectional German VitaMinFemin study, fatty acid levels in the erythrocyte membrane (% of total erythrocyte fatty acids) were ascertained for 446 women (40-60 years)...
February 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28225786/female-reproductive-factors-are-associated-with-objectively-measured-physical-activity-in-middle-aged-women
#14
Eija K Laakkonen, Janne Kulmala, Pauliina Aukee, Harto Hakonen, Urho M Kujala, Dawn A Lowe, Vuokko Kovanen, Tuija Tammelin, Sarianna Sipilä
Physical activity improves health and may delay the onset of several chronic diseases. For women in particular, the rate of these diseases accelerates at middle age; therefore it is important to identify the determinants of health-enhancing physical activity during midlife in this population. In this study, we focused on determinants that are unique to the female sex, such as childbearing and menopause. The main objective was to characterize the level of physical activity and differences between active and inactive middle-aged Finnish women...
2017: PloS One
https://www.readbyqxmd.com/read/28209529/menopausal-hormone-therapy-is-associated-with-increased-risk-of-fecal-incontinence-in-women-after-menopause
#15
Kyle Staller, Mary K Townsend, Hamed Khalili, Raaj Mehta, Francine Grodstein, William E Whitehead, Catherine A Matthews, Braden Kuo, Andrew T Chan
BACKGROUND & AIMS: Low estrogen levels could contribute to development of fecal incontinence (FI) in women after menopause by altering neuromuscular continence mechanisms. However, studies have produced conflicting results on the association between menopausal hormone therapy (MHT) and risk of FI. METHODS: We studied the association between MHT and risk of FI among 55,828 post-menopausal women (mean age 73 years) who participated in the Nurses' Health Study, enrolled since 2008, with no report of FI...
February 13, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28199328/association-of-pvuii-and-xbai-polymorphisms-on-estrogen-receptor-alpha-esr1-gene-to-changes-into-serum-lipid-profile-of-post-menopausal-women-effects-of-aging-body-mass-index-and-breast-cancer-incidence
#16
Neuza Felix Gomes-Rochette, Letícia Soncini Souza, Bruno Otoni Tommasi, Diego França Pedrosa, Sérgio Ragi Eis, Irani do Carmo Francischetto Fin, Fernando Luiz Herkenhoff Vieira, Jones Bernardes Graceli, Letícia Batista Azevedo Rangel, Ian Victor Silva
Estrogen is a steroidal hormone involved in several physiological functions in the female body including regulation of serum lipid metabolism and breast cancer (BC). Estrogen actions on serum lipids mostly occur through its binding to intracellular Estrogen Receptor alpha (ERalpha) isoform, expressed in most of tissues. This gene (ESR1) exhibit many polymorphic sites (SNPs) located either on translated and non-translated regions that regulate ERalpha protein expression and function. This paper aimed to investigate the association of two intronic SNPs of ESR1 gene, namely c454-397T>C (PvuII) and c454-351A>G (XbaI) to alterations in serum levels of total cholesterol (T-chol), total lipid (TL), low density lipoprotein cholesterol (LDL), high density lipoprotein (HDL), and triglycerides (TG) in a cohort of post-menopausal women...
2017: PloS One
https://www.readbyqxmd.com/read/28177709/effects-of-resistance-training-and-estrogen-replacement-on-adipose-tissue-inflammation-in-ovariectomized-rats
#17
Maria Fernanda Cury Rodrigues, Fabiano Candido Ferreira, Natália Santanielo Silva-Magosso, Marina Rodrigues Barbosa, Markus Vinicius Campos Souza, Mateus Moraes Domingos, Gustavo Henrique Rigo Canevazzi, Uliana Sbeguen Stotzer, Sabrina Messa Peviani, Fábio Santos de Lira, Heloísa Sobreiro Selistre de Araújo, Sérgio Eduardo de Andrade Perez
Estrogen deficiency is directly related to central obesity and low-grade inflammation. Hormonal replacement and exercise training are both able to decrease fat accumulation and inflammation in postmenopausal women. However, the efficiency of resistance training (RT) and estrogen replacement (ER) in minimizing adiposity and inflammation in the visceral adipose tissue (VAT) of ovariectomized (OVX) rats has not yet been elucidated. In this study, Sprague-Dawley rats were divided into the following six groups: the sham-operated sedentary (Sham-Sed), ovariectomized sedentary (OVX-Sed), sham-operated resistance training (Sham-RT), OVX-RT, OVX-Sed-ER and OVX-RT-ER groups...
January 25, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28176013/impact-of-reproductive-factors-on-breast-cancer-subtypes-in-postmenopausal-women-a-retrospective-single-center-study
#18
Alexandra von Au, Mona Klotzbuecher, Lorenz Uhlmann, Mark Boudewijns, Laura Michel, Markus Wallwiener, Joerg Heil, Michael Golatta, Joachim Rom, Christof Sohn, Andreas Schneeweiss, Florian Schuetz, Christoph Domschke
PURPOSE: Some reproductive factors are well-known general risk factors for breast cancer (BC). On the other hand, BC subtypes also have a high prognostic value. Correlations, however, that link these risk factors to the development of a particular one of the different BC subtypes are still poorly understood. The primary objective of our study was to assess the influence of different reproductive factors (duration of breastfeeding, parity, and age at first childbirth) on pathological BC subtypes...
February 7, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28169916/pharmacodynamic-effects-of-the-fetal-estrogen-estetrol-in-postmenopausal-women-results-from-a-multiple-rising-dose-study
#19
Herjan J T Coelingh Bennink, Carole Verhoeven, Yvette Zimmerman, Monique Visser, Jean-Michel Foidart, Kristina Gemzell-Danielsson
OBJECTIVE: Estetrol (E4) is an estrogen produced exclusively by the human fetal liver during pregnancy. In this study the pharmacodynamic effects of escalating doses of E4 in postmenopausal women were investigated. METHODS: This was a partly randomized, open-label, multiple-rising-dose study in 49 postmenopausal women. Participants were randomized to receive either 2 mg E4 or 2 mg estradiol-valerate (E2 V) for 28 days. Subsequent dose-escalation groups were (non-randomized): 10, 20 and 40 mg E4...
February 6, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28152707/chemotherapy-costs-associated-with-receipt-of-the-adoption-of-oncotype-dx-in-early-stage-breast-cancer-within-the-seer-medicare-population
#20
Xiaojuan Mi, Shelby D Reed, Gary H Lyman, Lesley H Curtis
32 Background: The Oncotype DX (ODX) multigene assay has been previously suggested to result in an overall reduction in the use of adjuvant chemotherapy and associated costs for women with early stage, estrogen receptor (ER)-positive breast cancer. However, the association between adoption of ODX and chemotherapy costs has only previously been considered in theoretical models and has not been examined using actual patient outcomes in real world clinical practice. METHODS: Retrospective analysis of Surveillance, Epidemiology, and End Results (SEER) -Medicare data of the association between overall and chemotherapy-specific costs associated with adoption of ODX testing in patients diagnosed with invasive, non-metastatic, ER-positive breast cancer between 2005 and 2009...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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