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Women and low estrogen

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https://www.readbyqxmd.com/read/28209529/menopausal-hormone-therapy-is-associated-with-increased-risk-of-fecal-incontinence-in-women-after-menopause
#1
Kyle Staller, Mary K Townsend, Hamed Khalili, Raaj Mehta, Francine Grodstein, William E Whitehead, Catherine A Matthews, Braden Kuo, Andrew T Chan
BACKGROUND & AIMS: Low estrogen levels could contribute to development of fecal incontinence (FI) in women after menopause by altering neuromuscular continence mechanisms. However, studies have produced conflicting results on the association between menopausal hormone therapy (MHT) and risk of FI. METHODS: We studied the association between MHT and risk of FI among 55,828 post-menopausal women (mean age 73 years) who participated in the Nurses' Health Study, enrolled since 2008, with no report of FI...
February 13, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28199328/association-of-pvuii-and-xbai-polymorphisms-on-estrogen-receptor-alpha-esr1-gene-to-changes-into-serum-lipid-profile-of-post-menopausal-women-effects-of-aging-body-mass-index-and-breast-cancer-incidence
#2
Neuza Felix Gomes-Rochette, Letícia Soncini Souza, Bruno Otoni Tommasi, Diego França Pedrosa, Sérgio Ragi Eis, Irani do Carmo Francischetto Fin, Fernando Luiz Herkenhoff Vieira, Jones Bernardes Graceli, Letícia Batista Azevedo Rangel, Ian Victor Silva
Estrogen is a steroidal hormone involved in several physiological functions in the female body including regulation of serum lipid metabolism and breast cancer (BC). Estrogen actions on serum lipids mostly occur through its binding to intracellular Estrogen Receptor alpha (ERalpha) isoform, expressed in most of tissues. This gene (ESR1) exhibit many polymorphic sites (SNPs) located either on translated and non-translated regions that regulate ERalpha protein expression and function. This paper aimed to investigate the association of two intronic SNPs of ESR1 gene, namely c454-397T>C (PvuII) and c454-351A>G (XbaI) to alterations in serum levels of total cholesterol (T-chol), total lipid (TL), low density lipoprotein cholesterol (LDL), high density lipoprotein (HDL), and triglycerides (TG) in a cohort of post-menopausal women...
2017: PloS One
https://www.readbyqxmd.com/read/28177709/effects-of-resistance-training-and-estrogen-replacement-on-adipose-tissue-inflammation-in-ovariectomized-rats
#3
Maria Fernanda Cury Rodrigues, Fabiano Candido Ferreira, Natália Santanielo Silva-Magosso, Marina Rodrigues Barbosa, Markus Vinicius Campos Souza, Mateus Moraes Domingos, Gustavo Henrique Rigo Canevazzi, Uliana Sbeguen Stotzer, Sabrina Messa Peviani, Fábio Santos de Lira, Heloísa Sobreiro Selistre de Araújo, Sérgio Eduardo de Andrade Perez
Estrogen deficiency is directly related to central obesity and low-grade inflammation. Hormonal replacement and exercise training are both able to decrease fat accumulation and inflammation in postmenopausal women. However, the efficiency of resistance training (RT) and estrogen replacement (ER) in minimizing adiposity and inflammation in the visceral adipose tissue (VAT) of ovariectomized (OVX) rats has not yet been elucidated. In this study, Sprague-Dawley rats were divided into the following six groups: the sham-operated sedentary (Sham-Sed), ovariectomized sedentary (OVX-Sed), sham-operated resistance training (Sham-RT), OVX-RT, OVX-Sed-ER and OVX-RT-ER groups...
January 25, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28176013/impact-of-reproductive-factors-on-breast-cancer-subtypes-in-postmenopausal-women-a-retrospective-single-center-study
#4
Alexandra von Au, Mona Klotzbuecher, Lorenz Uhlmann, Mark Boudewijns, Laura Michel, Markus Wallwiener, Joerg Heil, Michael Golatta, Joachim Rom, Christof Sohn, Andreas Schneeweiss, Florian Schuetz, Christoph Domschke
PURPOSE: Some reproductive factors are well-known general risk factors for breast cancer (BC). On the other hand, BC subtypes also have a high prognostic value. Correlations, however, that link these risk factors to the development of a particular one of the different BC subtypes are still poorly understood. The primary objective of our study was to assess the influence of different reproductive factors (duration of breastfeeding, parity, and age at first childbirth) on pathological BC subtypes...
February 7, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28169916/pharmacodynamic-effects-of-the-fetal-estrogen-estetrol-in-postmenopausal-women-results-from-a-multiple-rising-dose-study
#5
Herjan J T Coelingh Bennink, Carole Verhoeven, Yvette Zimmerman, Monique Visser, Jean-Michel Foidart, Kristina Gemzell-Danielsson
OBJECTIVE: Estetrol (E4) is an estrogen produced exclusively by the human fetal liver during pregnancy. In this study the pharmacodynamic effects of escalating doses of E4 in postmenopausal women were investigated. METHODS: This was a partly randomized, open-label, multiple-rising-dose study in 49 postmenopausal women. Participants were randomized to receive either 2 mg E4 or 2 mg estradiol-valerate (E2 V) for 28 days. Subsequent dose-escalation groups were (non-randomized): 10, 20 and 40 mg E4...
February 6, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28152707/chemotherapy-costs-associated-with-receipt-of-the-adoption-of-oncotype-dx-in-early-stage-breast-cancer-within-the-seer-medicare-population
#6
Xiaojuan Mi, Shelby D Reed, Gary H Lyman, Lesley H Curtis
: 32 Background: The Oncotype DX (ODX) multigene assay has been previously suggested to result in an overall reduction in the use of adjuvant chemotherapy and associated costs for women with early stage, estrogen receptor (ER)-positive breast cancer. However, the association between adoption of ODX and chemotherapy costs has only previously been considered in theoretical models and has not been examined using actual patient outcomes in real world clinical practice. METHODS: Retrospective analysis of Surveillance, Epidemiology, and End Results (SEER) -Medicare data of the association between overall and chemotherapy-specific costs associated with adoption of ODX testing in patients diagnosed with invasive, non-metastatic, ER-positive breast cancer between 2005 and 2009...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28130434/selective-progesterone-receptor-modulator-sprm-ulipristal-acetate-upa-and-its-effects-on-the-human-endometrium
#7
L H R Whitaker, A A Murray, R Matthews, G Shaw, A R W Williams, P T K Saunders, H O D Critchley
STUDY QUESTION: What is the impact of administration of the selective progesterone receptor modulator (SPRM), ulipristal acetate (UPA) on the endometrium of women with fibroids? SUMMARY ANSWER: UPA administration altered expression of sex-steroid receptors and progesterone-regulated genes and was associated with low levels of glandular and stromal cell proliferation. WHAT IS KNOWN ALREADY: Administration of all SPRM class members results in PAEC (progesterone receptor modulator associated endometrial changes)...
January 26, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28125816/comparative-anatomy-of-the-ovine-and-female-pelvis
#8
Iva Urbankova, Katarina Vdoviakova, Rita Rynkevic, Nikhil Sindhwani, Dries Deprest, Andrew Feola, Paul Herijgers, Ladislav Krofta, Jan Deprest
BACKGROUND: Pelvic organ prolapse affects half of vaginally parous women. Several animal models are used to study its pathophysiology and treatment. Sheep are interesting because they develop spontaneously prolapse with similar risk factors as women and can be used for vaginal surgery. This study describes ovine pelvis anatomy and compares it to women's pelvis to provide anatomical tools for translational researchers. METHODS: MRI, pelvic dissections, and histology were used for detailed macro- and microscopic analysis of relevant anatomical structures in 6 nulliparous ewes...
January 27, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28120435/oncotype-dx-recurrence-score-among-brca1-2-germline-mutation-carriers-with-hormone-receptors-positive-breast-cancer
#9
Naama Halpern, Amir Sonnenblick, Beatrice Uziely, Luba Divinsky, Yael Goldberg, Tamar Hamburger, Tamar Peretz, Luna Kadouri
Gene expression assays are widely used to predict risk of recurrence in early breast cancer (BC). We report the 21-gene expression assay (Oncotype Dx) recurrence score (RS) distribution of 27 BRCA carriers with estrogen receptor (ER) positive BCs, identified at Hadassah Medical Center, combined with 2 previous studies. Treatment decision and outcomes of the 27 BRCA carriers were compared with an Israeli cohort of 1594 patients published recently. We found Oncotype Dx RS low (<18), intermediate (18-30), and high (>30) among 12 (21...
January 24, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28117266/genotypes-and-haplotypes-of-the-estrogen-receptor-%C3%AE-gene-esr1-are-associated-with-female-to-male-gender-dysphoria
#10
Joselyn Cortés-Cortés, Rosa Fernández, Nerea Teijeiro, Esther Gómez-Gil, Isabel Esteva, Mari Cruz Almaraz, Antonio Guillamón, Eduardo Pásaro
INTRODUCTION: Gender dysphoria, a marked incongruence between one's experienced gender and biological sex, is commonly believed to arise from discrepant cerebral and genital sexual differentiation. With the discovery that estrogen receptor β is associated with female-to-male (FtM) but not with male-to-female (MtF) gender dysphoria, and given estrogen receptor α involvement in central nervous system masculinization, it was hypothesized that estrogen receptor α, encoded by the ESR1 gene, also might be implicated...
January 20, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28116469/adipokines-may-mediate-the-relationship-between-resting-metabolic-rates-and-bone-mineral-densities-in-obese-women
#11
S Moradi, K Mirzaei, A A Abdurahman, S A Keshavarz
: The researchers sought to test the possible link between resting metabolic rate and bone mineral density through four adipokines. Participants with lower resting metabolic rate (RMR) per kilogram demonstrated higher total bone mineral density (BMD), total T-score, and total Z-score. Omentin-1 had a mediatory effect on the relationship between RMR/kg of body weight and bone parameters. INTRODUCTION: The previous results of studies regarding the links between obesity and bone health are controversial...
January 23, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28114909/low-glycemic-index-diet-exercise-and-vitamin-d-to-reduce-breast-cancer-recurrence-dedica-design-of-a-clinical-trial
#12
Livia S A Augustin, Massimo Libra, Anna Crispo, Maria Grimaldi, Michele De Laurentiis, Massimo Rinaldo, Massimiliano D'Aiuto, Francesca Catalano, Giuseppe Banna, Francesco Ferrau', Rosalba Rossello, Diego Serraino, Ettore Bidoli, Samuele Massarut, Guglielmo Thomas, Davide Gatti, Ernesta Cavalcanti, Monica Pinto, Gabriele Riccardi, Edward Vidgen, Cyril W C Kendall, David J A Jenkins, Gennaro Ciliberto, Maurizio Montella
BACKGROUND: Mechanisms influencing breast cancer (BC) development and recurrence include hyperglycemia, hyperinsulinemia, high insulin-like growth factor-1, high circulating estrogen, inflammation and impaired cellular differentiation/apoptosis. A lifestyle program that targets all the above mechanisms may be warranted. Low glycemic index (GI) foods produce lower post-prandial glucose and insulin responses and have been associated with lower BC risk. Moderate physical activity post-diagnosis reduces BC recurrence and mortality, partly explained by reduced insulin and estrogen levels...
January 23, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28114189/androgen-receptor-expression-in-endometrial-stromal-sarcoma-correlation-with-clinicopathologic-features
#13
Maitrayee Roy, Sunesh Kumar, Neerja Bhatla, Mukurdipi D Ray, Lalit Kumar, Deepali Jain, Ravi Phulware, Sandeep R Mathur
Endometrial stromal sarcoma (ESS) is a rare neoplasm comprising only 0.2% to 1% of all uterine malignancies and afflicts women between 42 and 59 yr of age. ESSs frequently express estrogen receptor (ER) and progesterone receptor (PR). However, the published literature contains scant data on the expression and therapeutic/prognostic role of androgen receptor (AR) in ESSs. We undertook this study to characterize the expression of AR along with ER and PR in ESSs and correlate it with clinicopathologic features...
January 20, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28109853/variants-of-estrogen-receptor-alpha-and-beta-genes-modify-the-severity-of-sporadic-breast-cancer
#14
Luciana Montes Rezende, Fernando Augusto Lima Marson, Carmen Sílvia Passos Lima, Carmen Sílvia Bertuzzo
INTRODUCTION: Reproductive factors pose a risk for sporadic breast cancer(BC) development owing to the lifetime exposure to estrogen, a hormone responsible for cell proliferation in the breast. Because variants of the estrogen receptor(ER) alpha and beta genes have been associated with BC risk in numerous populations, the objective of the study was to determine whether the risk and severity of sporadic BC was associated with the rs2228480(ESR1) and rs4986938(ESR2) variants in a Brazilian population...
January 18, 2017: Gene
https://www.readbyqxmd.com/read/28109826/biological-relevance-of-effects-following-chronic-administration-of-octamethylcyclotetrasiloxane-d4-in-fischer-344-rats
#15
Wolfgang Dekant, Anthony R Scialli, Kathy Plotzke, James E Klaunig
Octamethylcyclotetrasiloxane (D4) is a cyclic siloxane primarily used as a monomer or intermediate in the production of silicone polymers resulting in potential exposure of workers, and potential low level inhalation or dermal exposure for consumers and the general public. Following a two-year inhalation toxicity study with D4 in rats, increases in uterine endometrial cystic hyperplasia and adenomas were observed at the highest concentration of D4 administered (700ppm). No other neoplasms were increased with D4 treatment...
January 18, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28098598/science-of-intracrinology-in-postmenopausal-women
#16
Fernand Labrie, Alain Bélanger, Georges Pelletier, Céline Martel, David F Archer, Wulf H Utian
OBJECTIVE: To illustrate the marked differences between classical endocrinology that distributes hormones to all tissues of the body through the bloodstream and the science of intracrinology, whereby each cell of each peripheral tissue makes a small and appropriate amount of estrogens and androgens from the inactive precursor dehydroepiandrosterone (DHEA), DHEA being mainly of adrenal origin. Because only the inactivated sex steroids are released in the blood, influence in the other tissues is avoided...
January 16, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28096640/prevalence-of-metabolic-syndrome-in-pre-and-post-menopausal-women-a-prospective-study-from-apex-institute-of-north-india
#17
Sandeep Sharma, Neelam Aggarwal, Bharti Joshi, Vanita Suri, Sanjay Badada
BACKGROUND: The metabolic syndrome (MS) (syndrome X, insulin resistance syndrome) is a constellation of metabolic abnormalities and a complex predisease state that predicts future development of type 2 diabetes mellitus and cardiovascular disease. Menopausal transition and postmenopausal state are considered as a vulnerable period for developing MS, and this increased risk has been attributed to decreasing estrogen levels with an increasing risk of insulin resistance following menopause...
October 2016: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28093566/estrogen-dependent-association-of-hdac4-with-fear-in-female-mice-and-women-with-ptsd
#18
S A Maddox, V Kilaru, J Shin, T Jovanovic, L M Almli, B G Dias, S D Norrholm, N Fani, V Michopoulos, Z Ding, K N Conneely, E B Binder, K J Ressler, A K Smith
Women are at increased risk of developing post-traumatic stress disorder (PTSD) following a traumatic event. Recent studies suggest that this may be mediated, in part, by circulating estrogen levels. This study evaluated the hypothesis that individual variation in response to estrogen levels contributes to fear regulation and PTSD risk in women. We evaluated DNA methylation from blood of female participants in the Grady Trauma Project and found that serum estradiol levels associates with DNA methylation across the genome...
January 17, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28090005/unstable-angina-pectoris-in-a-22-year-old-female-patient
#19
Hanae Yoshimura, Toyoharu Oba, Takanobu Nagata, Eita Kumagai, Naoki Itaya, Naohiro Yoshikawa, Daiki Akagaki, Hideki Ohshima, Michihide Nishihara, Takafumi Ueno, Yoshihiro Fukumoto
Because of the protective effect of estrogen for atherosclerosis, the prevalence of acute coronary syndrome in women before menopause is low. We report a rare case of unstable angina in a young Japanese female who had a history of cigarette smoking and contraceptive use. Her coronary stenosis was successfully treated by percutaneous coronary intervention.
January 16, 2017: Kurume Medical Journal
https://www.readbyqxmd.com/read/28064523/iranian-postmenopausal-women-s-experiences-of-treatment-of-symptomatic-vulvovaginal-atrophy
#20
E Fooladi, M Deldar, F Mohammadzadeh, E Ahmadnia, S Khani, Z Ghanbari
OBJECTIVES: Our aim was to explore the experiences of Iranian postmenopausal women who sought medical help for their symptomatic vulvovaginal atrophy (VVA). METHODS: Five focus group discussions (FGDs) were conducted. Participants had to be postmenopausal; had bothersome symptoms of VVA for which they came to the clinic; had previously sought medical help for their VVA; and had confirmed physical signs of VVA upon examination by a gynecologist. RESULTS: Twenty-five women, aged 49-60 years participated in the five FGDs...
February 2017: Climacteric: the Journal of the International Menopause Society
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