keyword
https://read.qxmd.com/read/38525109/b-cell-pathway-dual-inhibition-for-systemic-lupus-erythematosus-a-prospective-single-arm-cohort-study-of-telitacicept
#1
JOURNAL ARTICLE
Lanlan Ji, Yan Geng, Xiaohui Zhang, Xuerong Deng, Zhibo Song, Meng Tan, Ying Tan, Chenxue Qu, Zhuoli Zhang
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease associated with B-cell hyperactivity. Telitacicept is a transmembrane activator, calcium modulator, and cyclophilin ligand interactor-Fc fusion protein, which can neutralize both B-cell lymphocyte stimulator and a proliferation-inducing ligand. Patients with active SLE who received telitacicept were prospectively followed at month 1, 3, 6, 9, and 12 after telitacicept initiation. Thirty-seven participants were involved and followed for 6...
April 2024: MedComm
https://read.qxmd.com/read/38524696/impaired-health-related-quality-of-life-in-idiopathic-inflammatory-myopathies-a-cross-sectional-analysis-from-the-covad-2-e-survey
#2
JOURNAL ARTICLE
Akira Yoshida, Yuan Li, Vahed Maroufy, Masataka Kuwana, Syahrul Sazliyana Shaharir, Ashima Makol, Parikshit Sen, James B Lilleker, Vishwesh Agarwal, Esha Kadam, Phonpen Akawatcharangura Goo, Jessica Day, Marcin Milchert, Yi-Ming Chen, Dzifa Dey, Tsvetelina Velikova, Sreoshy Saha, Abraham Edgar Gracia-Ramos, Ioannis Parodis, Elena Nikiphorou, Ai Lyn Tan, Arvind Nune, Lorenzo Cavagna, Carlos Enrique Toro Gutiérrez, Carlo Vinicio Caballero-Uribe, Miguel A Saavedra, Samuel Katsuyuki Shinjo, Nelly Ziade, Lina El Kibbi, Johannes Knitza, Oliver Distler, Hector Chinoy, Vikas Agarwal, Rohit Aggarwal, Latika Gupta
OBJECTIVES: To investigate health-related quality of life in patients with idiopathic inflammatory myopathies (IIMs) compared with those with non-IIM autoimmune rheumatic diseases (AIRDs), non-rheumatic autoimmune diseases (nrAIDs) and without autoimmune diseases (controls) using Patient-Reported Outcome Measurement Information System (PROMIS) instrument data obtained from the second COVID-19 vaccination in autoimmune disease (COVAD-2) e-survey database. METHODS: Demographics, diagnosis, comorbidities, disease activity, treatments and PROMIS instrument data were analysed...
2024: Rheumatology Advances in Practice
https://read.qxmd.com/read/38523857/co-existence-of-type-1-diabetes-mellitus-and-myasthenia-gravis-a%C3%A2-case-report-and-review-of-the-literature
#3
Sabitha Sasidharan Pillai, Kate Millington
BACKGROUND/OBJECTIVE: Type 1 diabetes (T1D) and myasthenia gravis (MG) are autoimmune conditions that rarely co-occur. Here, we report a child with MG who subsequently developed T1D. CASE REPORT: An 11-year-old girl with seropositive MG diagnosed at 4 years of age presented with muscle pain, cramps, and weight loss of 3.5 kg over 4 months. Her MG was in remission on daily pyridostigmine. She denied polyuria, polydipsia, recent illnesses, or other medications...
2024: AACE Clinical Case Reports
https://read.qxmd.com/read/38518094/neuropsychiatric-symptoms-in-systemic-lupus-erythematosus-mixed-methods-analysis-of-patient-derived-attributional-evidence-in-the-international-inspire-project
#4
JOURNAL ARTICLE
Melanie Sloan, Thomas A Pollak, Efthalia Massou, Guy Leschziner, Laura Andreoli, Rupert Harwood, Michael Bosley, Mervi Pitkanen, Wendy Diment, Alessandra Bortoluzzi, Michael S Zandi, Mandeep Ubhi, Caroline Gordon, David Jayne, Felix Naughton, Colette Barrere, Chris Wincup, James Brimicombe, James A Bourgeois, David D'Cruz
OBJECTIVE: Attribution of neuropsychiatric symptoms in systemic lupus erythematosus (SLE) relies heavily on clinician assessment. Limited clinic time, variable knowledge, and symptom under-reporting contributes to discordance between clinician assessments and patient symptoms. We obtained attributional data directly from patients and clinicians in order to estimate and compare potential levels of direct attribution to SLE of multiple neuropsychiatric symptoms using different patient-derived measures...
March 22, 2024: Rheumatology
https://read.qxmd.com/read/38509608/randomized-controlled-double-blind-trial-of-methylprednisolone-versus-placebo-in-patients-with-post-covid-19-syndrome-and-cognitive-deficits-study-protocol-of-the-post-corona-virus-immune-treatment-pocovit-trial
#5
JOURNAL ARTICLE
Christiana Franke, Vanessa Raeder, Fabian Boesl, Benno Bremer, Lucas C Adam, Ameli Gerhard, Irina Eckert, Anneke Quitschau, Anne Pohrt, Susen Burock, Lisa Bruckert, Carmen Scheibenbogen, Harald Prüß, Heinrich J Audebert
INTRODUCTION: Post-COVID-19 Syndrome (PCS) includes neurological manifestations, especially fatigue and cognitive deficits. Immune dysregulation, autoimmunity, endothelial dysfunction, viral persistence, and viral reactivation are discussed as potential pathophysiological mechanisms. The post-corona-virus immune treatment (PoCoVIT) trial is a phase 2a randomized, controlled, double-blind trial designed to evaluate the effect of methylprednisolone versus placebo on cognitive impairment in PCS...
March 21, 2024: Neurological research and practice
https://read.qxmd.com/read/38509358/-current-patient-care-of-systematic-lupus-erythematosus-in-rhineland-palatinate-and-saarland
#6
JOURNAL ARTICLE
Ciaran Alberti, Matthias Dreher, Konstantinos Triantafyllias, Andreas Schwarting
BACKGROUND: Systemic lupus erythematosus (SLE) is a clinically heterogeneous autoimmune disease that is associated with great suffering for those affected, as well as high socioeconomic costs. Early diagnosis and adequate medical care are essential for a mild course of the disease. However, there is a lack of current figures and data on the care situation of patients in the area. METHODOLOGY: A total of 1546 general practitioners, rheumatologists, neurologists, nephrologists and dermatologists in Rhineland-Palatinate and Saarland were interviewed by fax or mail using a questionnaire regarding epidemiology, symptoms, therapy and therapy success...
March 20, 2024: Zeitschrift Für Rheumatologie
https://read.qxmd.com/read/38505266/case-series-raw-whole-plant-based-nutrition-protocol-rapidly-reverses-symptoms-in-three-women-with-systemic-lupus-erythematosus-and-sj%C3%A3-gren-s-syndrome
#7
Brooke Goldner, Kara Livingston Staffier
Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) are chronic autoimmune diseases. Symptoms of SLE can vary widely but often include fatigue, pain, photosensitivity, and, in some cases, nephritis. SS is frequently characterized by extreme dry eye and mouth, resulting from damage to moisture-producing glands, and is often present in combination with SLE. While the health benefits of plant-based diets have been well-established with respect to weight and cardiometabolic outcomes, less research is available to support the role of diet in treatment and management of autoimmune disease...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38500920/severe-spinal-cord-inflammation-in-a-young-woman-diagnosed-with-systemic-lupus-erythematosus-a-case-study
#8
Vemparala Priyatha, Aizaz A Shah, Saad Ijaz, Sohaib Ur Rahman, Hidayat Ullah, Wardah Tariq, Noman Salih
We describe a case of longitudinally extensive transverse myelitis (LETM), an uncommon and dangerous complication of systemic lupus erythematosus (SLE) that struck a 22-year-old woman with SLE. Chronic autoimmune illness (e.g., SLE) affects the skin, kidneys, joints, blood, and neurological system, among other organs. LETM is a condition where the spinal cord becomes inflamed and damaged, causing neurological problems, such as weakness, sensory loss, and bladder dysfunction. The patient presented with abdominal pain, vomiting, body aches, and fatigue, followed by shock, hypoxia, urinary retention, and constipation...
February 2024: Curēus
https://read.qxmd.com/read/38492082/pregnancy-in-myasthenia-gravis-a-retrospective-analysis-of-maternal-and-neonatal-outcome-from-a-large-tertiary-care-centre-in-germany
#9
JOURNAL ARTICLE
Jakob Draxler, Andreas Meisel, Frauke Stascheit, Maike Stein, Lea Gerischer, Philipp Mergenthaler, Meret Herdick, Paolo Doksani, Sophie Lehnerer, Stefan Verlohren, Sarah Hoffmann
PURPOSE: Myasthenia gravis (MG) is a rare, potentially life-threatening autoimmune disease with fluctuating muscle weakness frequently affecting women of childbearing age. MG can affect maternal as well as neonatal outcome with risk of worsening of myasthenic symptoms in the mothers and risk of transient neonatal myasthenia gravis (TNMG) and arthrogryposis multiplex congenita (AMC) or foetal acetylcholine receptor antibody-associated disorders (FARAD) in the neonates. METHODS: Retrospective analysis of maternal and neonatal outcome in a cohort of pregnant MG patients treated at a tertiary care centre in Germany...
March 16, 2024: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/38489062/safety-of-biological-therapies-for-severe-asthma-an-analysis-of-suspected-adverse-reactions-reported-in-the-who-pharmacovigilance-database
#10
JOURNAL ARTICLE
Paola Maria Cutroneo, Elena Arzenton, Fabiana Furci, Fabio Scapini, Maria Bulzomì, Nicoletta Luxi, Marco Caminati, Gianenrico Senna, Ugo Moretti, Gianluca Trifirò
BACKGROUND: The management of uncontrolled severe asthma has greatly improved since the advent of novel biologic therapies. Up to August 2022, five biologics have been approved for the type 2 asthma phenotype: anti-IgE (omalizumab), anti-IL5 (mepolizumab, reslizumab, benralizumab), and anti-IL4 (dupilumab) monoclonal antibodies. These drugs are usually well tolerated, although long-term safety information is limited, and some adverse events have not yet been fully characterized. Spontaneous reporting systems represent the cornerstone for the detection of potential signals and evaluation of the real-world safety of all marketed drugs...
March 15, 2024: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://read.qxmd.com/read/38477782/risk-of-fracture-in-patients-with-myasthenia-gravis-a-nationwide-cohort-study-in-korea
#11
JOURNAL ARTICLE
Hye-Sun Park, Kyoungsu Kim, Min Heui Yu, Ha Young Shin, Yumie Rhee, Seung Woo Kim, Namki Hong
Myasthenia gravis (MG) is an autoimmune disorder that affects the neuromuscular junctions, resulting in muscle weakness and fatigue. Muscle weakness, restricted mobility, and frequent use of corticosteroids in patients with MG may predispose them to a higher risk of fractures. However, studies on the impact of MG on bone health and the associated fracture risk are scarce. Utilizing claim database of the Korean National Health Insurance Service collected between 2002 and 2020, we compared the risk of major osteoporotic fracture between 23 118 patients with MG and 115 590 individuals as an age- and sex-matched control group using multivariable Cox proportional hazard models...
March 12, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38469308/case-report-successful-treatment-of-an-anti-d2r-and-dppx-antibody-associated-autoimmune-encephalitis-patient-with-high-dose-methylprednisolone-and-intravenous-immunoglobulin
#12
Zhangliang Lin, Feng Zhou, Lili Ni, Shiye Dong, Guoping Fu, Jiangman Zhao
BACKGROUND: Autoimmune encephalitis is a neurological condition caused by abnormal immune responses, manifesting as cognitive impairments, behavioral abnormalities, and seizures. Its diagnosis depends on the detecting neuronal surface antibodies in serum or cerebrospinal fluid. Despite recent advances in understanding, clinical recognition remains challenging, especially with rare antibodies such as anti-dopamine D2 receptor (D2R) and anti-dipeptidyl-peptidase-like protein 6 (DPPX) antibodies...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38460606/celiac-disease-related-conditions-who-to-test
#13
JOURNAL ARTICLE
Fabiana Zingone, Julio C Bai, Christophe Cellier, Jonas F Ludvigsson
Celiac disease (CeD) is a chronic immune-mediated condition triggered by gluten consumption in genetically predisposed individuals. Approximately 1% of the general population is affected by the disorder. Disease presentation is heterogeneous, and despite growing awareness among physicians and the public, it continues to be underestimated. The most effective strategy for identifying undiagnosed CeD is proactive case-finding through serologic testing in high-risk groups. We reviewed the most recent evidence on the association between CeD and over 20 conditions...
March 7, 2024: Gastroenterology
https://read.qxmd.com/read/38457514/beyond-t-cell-exhaustion-tim-3-regulation-of-myeloid-cells
#14
REVIEW
Karen O Dixon, Gonzalo Fernandez Lahore, Vijay K Kuchroo
T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) is an important immune checkpoint molecule initially identified as a marker of IFN-γ-producing CD4+ and CD8+ T cells. Since then, our understanding of its role in immune responses has significantly expanded. Here, we review emerging evidence demonstrating unexpected roles for TIM-3 as a key regulator of myeloid cell function, in addition to recent work establishing TIM-3 as a delineator of terminal T cell exhaustion, thereby positioning TIM-3 at the interface between fatigued immune responses and reinvigoration...
March 8, 2024: Science Immunology
https://read.qxmd.com/read/38445131/moyamoya-syndrome-differential-diagnosis-in-patients-with-central-nervous-system-symptoms-and-hyperthyroidism
#15
Yosuke Maezawa, Kazuya Nagasaki, Hitoshi Aiyama, Yuki Yamamoto, Yasushi Shibata
Moyamoya syndrome, known as secondary moyamoya disease, is associated with various primary illnesses, such as brain tumor, meningitis, autoimmune disease, and thyrotoxicosis, and their relations are not clear. We report a rare case of moyamoya syndrome in a patient with Graves' disease. An 18-year-old woman was admitted to our hospital due to convulsions. She had symptoms of palpitations and fatiguability for half a year and transient numbness in her left upper extremity and dysarthria for a month. In physical findings, tachycardia and diffuse thyroid swelling were noted...
February 2024: Curēus
https://read.qxmd.com/read/38444633/is-there-any-association-between-celiac-disease-myelodysplastic-symdrome-and-primary-sclerosing-cholangitis-a-rare-case-report
#16
Suaad Hamsho, Moudar Al Hariri, Bilal Sleiay, Abdul Hadi Daher Alhussen, Mouhammed Sleiay
Celiac disease (CD) is an autoimmune disease characterized by a specific serological and histological profile. Hematological findings are one of the most common presentations and can sometimes be the only manifestation of the disease. In patients with unexplained isolated hematological abnormalities, a high index of suspicion for CD is necessary. A 33-year-old woman was admitted to the Department of Gastroenterology and Hepatology because of abdominal pain and fatigue. She was diagnosed with myelodysplastic syndrome...
March 2024: JGH Open: An Open Access Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38442505/a-novel-biomarker-of-interleukin-6-activity-and-clinical-and-cognitive-outcomes-in-depression
#17
JOURNAL ARTICLE
Éimear M Foley, Chloe Slaney, Nicholas A Donnelly, Muzaffer Kaser, Louise Ziegler, Golam M Khandaker
BACKGROUND: Inflammatory cytokines like interleukin-6 (IL-6) are implicated in depression, but most studies have hitherto focused on circulating levels of IL-6 rather than its activity. IL-6 trans-signalling is thought to be responsible for most of the pathogenic effects of IL-6 and is implicated in autoimmune diseases like rheumatoid arthritis. We tested the association between a multi-protein-derived measure of IL-6 trans-signalling and clinical and cognitive outcomes in patients with depression...
February 29, 2024: Psychoneuroendocrinology
https://read.qxmd.com/read/38437852/identification-of-distinct-subgroups-of-sj%C3%A3-gren-s-disease-by-cluster-analysis-based-on-clinical-and-biological-manifestations-data-from-the-cross-sectional-paris-saclay-and-the-prospective-assess-cohorts
#18
JOURNAL ARTICLE
Yann Nguyen, Gaëtane Nocturne, Julien Henry, Wan-Fai Ng, Rakiba Belkhir, Frédéric Desmoulins, Elisabeth Bergé, Jacques Morel, Aleth Perdriger, Emmanuelle Dernis, Valérie Devauchelle-Pensec, Damien Sène, Philippe Dieudé, Marion Couderc, Anne-Laure Fauchais, Claire Larroche, Olivier Vittecoq, Carine Salliot, Eric Hachulla, Véronique Le Guern, Jacques-Eric Gottenberg, Xavier Mariette, Raphaèle Seror
BACKGROUND: Sjögren's disease is a heterogenous autoimmune disease with a wide range of symptoms-including dryness, fatigue, and pain-in addition to systemic manifestations and an increased risk of lymphoma. We aimed to identify distinct subgroups of the disease, using cluster analysis based on subjective symptoms and clinical and biological manifestations, and to compare the prognoses of patients in these subgroups. METHODS: This study included patients with Sjögren's disease from two independent cohorts in France: the cross-sectional Paris-Saclay cohort and the prospective Assessment of Systemic Signs and Evolution of Sjögren's Syndrome (ASSESS) cohort...
March 1, 2024: Lancet Rheumatology
https://read.qxmd.com/read/38433036/investigating-viral-and-autoimmune-t-cell-responses-associated-with-post-acute-sequelae-of-covid-19
#19
JOURNAL ARTICLE
Gregory P Williams, Esther Dawen Yu, Kendra Shapiro, Eric Wang, Antoine Freuchet, April Frazier, Cecilia S Lindestam Arlehamn, Alessandro Sette, Ricardo da Silva Antunes
Post-acute sequelae of COVID-19 (PASC), or Long COVID, is a chronic condition following acute SARS-CoV-2 infection. Symptoms include exertion fatigue, respiratory issues, myalgia, and neurological manifestations such as 'brain fog,' posing concern for their debilitating nature and potential role in other neurological disorders. However, the underlying potential pathogenic mechanisms of the neurological complications of PASC is largely unknown. Herein, we investigated differences in antigen-specific T cell responses from the peripheral blood towards SARS-CoV-2, latent viruses, or neuronal antigens in 14 PASC individuals with neurological manifestations (PASC-N) versus 22 individuals fully recovered from COVID-19...
March 2, 2024: Human Immunology
https://read.qxmd.com/read/38428964/factors-associated-with-an-electronic-health-record-based-definition-of-post-acute-sequelae-of-covid-19-in-patients-with-systemic-autoimmune-rheumatic-disease
#20
JOURNAL ARTICLE
Naomi J Patel, Xiaosong Wang, Miao Lin, Emily N Kowalski, Claire E Cook, Kathleen M M Vanni, Krishan Guzzo, Grace Qian, Katarina J Bade, Alene Saavedra, Rathnam Venkat, Shruthi Srivatsan, Zachary K Williams, Jennifer S Hanberg, Yumeko Kawano, Abigail E Schiff, Jeffrey A Sparks, Zachary S Wallace
OBJECTIVE: Many individuals with rheumatic disease are at higher risk for severe acute COVID-19. We aimed to evaluate risk factors for Post-Acute Sequelae of COVID-19 (PASC) using an electronic health record (EHR)-based definition. METHODS: We identified patients with prevalent rheumatic diseases and COVID-19 at Mass General Brigham. PASC was defined by ICD codes, relevant labs, vital signs, and medications, at least 30 days following the first COVID-19 infection...
March 1, 2024: Journal of Rheumatology
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