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https://www.readbyqxmd.com/read/29779216/glutamate-metabolism-in-cerebral-mitochondria-after-ischemia-and-post-ischemic-recovery-during-aging-relationships-with-brain-energy-metabolism
#1
Federica Ferrari, Antonella Gorini, Siegfried Hoyer, Roberto Federico Villa
Glutamate is involved in cerebral ischemic injury, but its role has not been completely clarified and studies are required to understand how minimize its detrimental effects, contemporarily boosting the positive ones. In fact, glutamate is not only a neurotransmitter, but primarily a key metabolite for brain bioenergetics. Thus, we investigated the relationships between glutamate and brain energy metabolism in an in vivo model of complete cerebral ischemia of 15 min and during post-ischemic recovery after 1, 24, 48, 72 and 96 hrs in 1 year- adult and 2 year-old aged rats...
May 20, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29778996/stent-and-flow-diverter-assisted-treatment-of-acutely-ruptured-brain-aneurysms
#2
José E Cohen, J Moshe Gomori, Ronen R Leker, Sergey Spektor, Hosni Abu El Hassan, Eyal Itshayek
OBJECTIVE: We present our experience with stent techniques in the management of acutely ruptured aneurysms, focusing on aneurysm occlusion rates, intraprocedural complications, and late outcomes. METHODS: We retrospectively reviewed the clinical records of patients treated by stent techniques during the early acute phase of aneurysmal rupture, from June 2011 to June 2016. Patients who underwent stenting for the management of unruptured aneurysms, or in a delayed fashion for a ruptured lesion, were excluded...
May 19, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29778841/sclerosing-alcohol-injections-for-the-management-of-intermetatarsal-neuromas-a-systematic-review
#3
REVIEW
Derek Santos, Graeme Morrison, Andrea Coda
An intermetatarsal neuroma is a plantar digital neuritis causing metatarsalgia of the affected inter-metatarsal space. At present the evidence to support the management of the condition is poor with only some quality evidence supporting the short-term management of intermetatarsal neuromas using steroid injections. Some authors have supported the use of alcohol sclerosing intra-lesional injections to treat intermetatarsal neuromas. Following a search of the evidence 11 articles were identified. The systematic review found that alcohol injections appear to be safe although some papers report a short-term side effect of a flogistic reaction and there are variances in the alcohol concentration used and guiding verses not guiding the injection using ultrasound imaging...
December 28, 2017: Foot
https://www.readbyqxmd.com/read/29778829/a-qualitative-investigation-of-the-attitudes-and-beliefs-about-physical-activity-and-post-traumatic-osteoarthritis-in-young-adults-3-10-years-after-an-intra-articular-knee-injury
#4
Allison M Ezzat, Mariana Brussoni, Jackie L Whittaker, Carolyn A Emery
OBJECTIVE: To understand the influence of the injury experience on current attitudes and beliefs about physical activity (PA) and the development of post-traumatic osteoarthritis (PTOA) in youth and young adults 3-10 years after a sport-related knee injury. DESIGN: Qualitative study. SETTING: University Sports Medical/Research Center. PARTICIPANTS: 20 young adults 3-10 years subsequent to intra-articular knee injury...
May 4, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29778827/intra-and-inter-reliability-of-fleximetry-in-individuals-with-chronic-shoulder-pain
#5
Iran Henrique da Silva, José Mariedson da Silva Junior, Aldair Darlan Santos-de-Araújo, Cid André Fidelis de Paula Gomes, Cesário da Silva Souza, Priscila Helena Vanin Alves de Souza Matias, Almir Vieira Dibai-Filho
OBJECTIVE: To evaluate the intra- and inter-rater reliability of fleximetry in the measurement of range of motion (ROM) in individuals with chronic shoulder pain. DESIGN: Reliability study. SETTING: Physiotherapy clinic. PARTICIPANTS: Thirty individuals of both genders, ages between 18 and 45 years, with chronic shoulder pain. MAIN OUTCOME MEASURES: Fleximetry was used to measurement shoulder ROM (flexion, hyperextension, abduction, medial and lateral rotation, and horizontal abduction and adduction)...
May 17, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29778826/intra-and-inter-rater-reliabilities-for-novel-muscle-thickness-assessment-during-co-contraction-with-dual-rehabilitative-ultrasound-imaging
#6
Hwang-Jae Lee, Hyun-Geun Ha, Joohee Hahn, Seungyeop Lim, Wan-Hee Lee
OBJECTIVES: This study aimed to investigate the intra- and inter-rater reliabilities of dual-rehabilitative ultrasound imaging (D-RUSI) for the simultaneous measurement of the thickness of the tibialis anterior (TA) and gastrocnemius (GCM) muscles in healthy young adults. DESIGN: A single-group repeated-measures reliability study. SETTING: Rehabilitative ultrasound imaging analysis laboratory. PARTICIPANTS: Thirty-six healthy participants (23 males; age = 26...
May 17, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29778821/evaluating-mastectomy-skin-flap-necrosis-in-the-extended-breast-reconstruction-risk-assessment-score-for-one-year-prediction-of-prosthetic-reconstruction-outcomes
#7
Nora Hansen, Sasa Espino, Jordan T Blough, Michael M Vu, Neil A Fine, John Ys Kim
BACKGROUND: Rates of mastectomy for breast cancer treatment and immediate reconstruction continue to rise. With increasing scrutiny on outcomes and patient satisfaction, there is an impetus for providers to be more deliberate in deciding appropriate patient selection for breast reconstruction. The Breast Reconstruction Risk Assessment (BRA) Score was developed for prediction of complications after primary prosthetic breast reconstruction, focusing on calculating risk estimations for a variety of complications based on individual patient demographics and perioperative characteristics...
May 17, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29778783/intra-vitreal-%C3%AE-b-crystallin-fused-to-elastin-like-polypeptide-provides-neuroprotection-in-a-mouse-model-of-age-related-macular-degeneration
#8
Parameswaran G Sreekumar, Zhe Li, Wan Wang, Christine Spee, David R Hinton, Ram Kannan, J Andrew MacKay
Age-related macular degeneration (AMD) is the leading cause of severe and irreversible central vision loss, and the primary site of AMD pathology is the retinal pigment epithelium (RPE). Geographic atrophy (GA) is an advanced form of AMD characterized by extensive RPE cell loss, subsequent degeneration of photoreceptors, and thinning of retina. This report describes the protective potential of a peptide derived from the αB crystallin protein using a sodium iodate (NaIO3 ) induced mouse model of GA. Systemic NaIO3 challenge causes degeneration of the RPE and neighboring photoreceptors, which have similarities to retinas of GA patients...
May 17, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29778750/our-modified-technique-of-combined-antegrade-vein-graft-cardioplegia-infusion-versus-conventional-antegrade-method-in-coronary-artery-bypass-grafting-a-randomized-clinical-trial
#9
Mehrzad Sharifi, Seyed Reza Mousavi, Mohammad Rafiei
BACKGROUND: To determine the efficacy of antegrade cardioplegia supplemented with venous graft perfusion in patients scheduled for coronary artery bypass grafting (CABG). METHODS: 223 consecutive patients scheduled for isolated CABG were randomized to receive either continuous crystalloid cardioplegia via vein grafts on completion of each distal anastomosis plus intermittent blood cardioplegia through aortic root (group 1, n = 110) or antegrade blood cardioplegia alone (group 2, n = 113)...
May 17, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29778608/technical-success-and-long-term-results-with-excluder-c3-endoprosthesis-in-narrow-aortic-biforcations-first-italian-multicentre-experience
#10
Gian Franco Veraldi, Luca Mezzetto, Filippo Vaccher, Lorenzo Scorsone, Stefano Bonvini, Igor Raunig, Valentina Wassermann, Sebastiano Tasselli
PURPOSE: This study aims at evaluating technical success and long-term results using Gore Excluder/C3 endoprosthesis in patients with narrow aortic bifurcation (NAB, inner-inner aortic diameter <18mm). METHODS: Clinical and anatomical data were collected retrospectively from patients treated in two high-volume Italian vascular centres between 2005 and 2017. A total of 1325 EVAR procedures were performed: 195 involved Excluder/C3 Gore endoprosthesis. 141 patients had a regular aortic bifurcation (RAB, maximum inner-inner diameter ≥ 18mm), while 54 presented NAB (< 18mm)...
May 17, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29778406/magnetic-nanocomposite-of-chitosan-schiff-base-grafted-graphene-oxide-for-lead-analysis-in-whole-blood
#11
Shahram Seidi, Mahshid Majd, Maryam Rezazadeh, Maryam Shanehsaz
A new Schiff base grafted graphene oxide-magnetic chitosan was utilized as a novel sorbent for extraction and quantification of lead ion in blood samples via dispersive magnetic solid phase extraction. The prepared nanocomposite sorbent was characterized by SEM, TEM, FT-IR, XRD, VSM and EDX and the quantification analysis was performed by microsampling flame atomic absorption spectrometry. The important parameters on the extraction efficiency were thoroughly optimized by means of experimental design. Under the optimized conditions, an aliquot of 50 mL of sample (pH 6...
May 17, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29778183/high-genetic-diversity-of-extended-spectrum-%C3%AE-lactamases-producing-escherichia-coli-in-feces-of-horses
#12
Syndia Sadikalay, Yann Reynaud, Stéphanie Guyomard-Rabenirina, Mélanie Falord, Célia Ducat, Laetitia Fabre, Simon Le Hello, Antoine Talarmin, Séverine Ferdinand
Extended-spectrum beta-lactamases (ESBLs), especially those of the CTX-M type, represent a major public health problem throughout the world. Although the carriage of ESBL-producing Enterobacteriaceae (EPE) in feces of horses is now well recognized, little is known about the diversity of EPE after treatment of horses with antibiotics. We undertook this study to assess and follow the diversity of EP Escherichia coli isolated from horses after antibiotic treatment for an infection. Fecal samples from two horses treated and two that were untreated were tested for the presence of EPE on different days...
June 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29778125/a-neonate-with-bilateral-vitreous-hemorrhages-after-intra-uterine-bowel-infarction-secondary-to-volvulus
#13
Des Bharti, Sugantha Krishnan
Vitreous hemorrhages are uncommon in the neonatal period. This article describes a neonatal who had bilateral vitreous hemorrhages after intrauterine bowel infarction.
June 2018: Journal of the National Medical Association
https://www.readbyqxmd.com/read/29778065/reliability-of-the-sub-components-of-the-instrumented-timed-up-and-go-test-in-ambulatory-children-with-traumatic-brain-injury-and-typically-developed-controls
#14
Mark A Newman, Mark A Hirsch, Richard D Peindl, Nahir A Habet, Tobias J Tsai, Michael S Runyon, Toan Huynh, Nigel Zheng
BACKGROUND: Studies have evaluated the test-re-test reliability of subcomponents of the timed up and-go test in adults by using body-worn inertial sensors. However, studies in children have not been reported in the literature. RESEARCH QUESTION: To evaluate the within-session reliability of subcomponents of a newly developed electronically augmented timed 'upand-go' test (EATUG) in ambulatory children with traumatic brain injury (TBI) and children with typical development (TD)...
May 16, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29777981/bare-footprint-metric-analysis-methods-for-comparison-and-identification-in-forensic-examinations-a-review-of-literature
#15
REVIEW
Richa Mukhra, Kewal Krishan, Tanuj Kanchan
Footprint is one of the most common types of physical evidence recovered at a crime scene. The forensic footprint evidence may play an important role in establishing the identity of a person; therefore, its examination is of prime importance. A link may be established by observing and comparing the morphological features of footprints with the perpetrator. These barefoot prints may be present as a two-dimensional print or a three-dimensional imprint depending on the substrate upon which they have been impressed upon and accordingly different methods and techniques are implemented in order to identify the questioned prints...
May 9, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29777956/how-do-gender-relations-affect-the-working-lives-of-close-to-community-health-service-providers-empirical-research-a-review-and-conceptual-framework
#16
Rosalind Steege, Miriam Taegtmeyer, Rosalind McCollum, Kate Hawkins, Hermen Ormel, Maryse Kok, Sabina Rashid, Lilian Otiso, Mohsin Sidat, Kingsley Chikaphupha, Daniel Gemechu Datiko, Rukhsana Ahmed, Rachel Tolhurst, Woedem Gomez, Sally Theobald
Close-to-community (CTC) providers have been identified as a key cadre to progress universal health coverage and address inequities in health service provision due to their embedded position within communities. CTC providers both work within, and are subject to, the gender norms at community level but may also have the potential to alter them. This paper synthesises current evidence on gender and CTC providers and the services they deliver. This study uses a two-stage exploratory approach drawing upon qualitative research from the six countries (Bangladesh, Indonesia, Ethiopia, Kenya, Malawi, Mozambique) that were part of the REACHOUT consortium...
May 5, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29777883/atypical-presentation-of-giant-aneurysm-in-a-pediatric-patient-with-duane-syndrome
#17
Chao-Hung Kuo, Lynn B McGrath, Joseph A Carnevale, Neena I Marupudi, Jeffery G Ojemann, Richard G Ellenbogen, Anthony C Wang
BACKGROUND: Duane syndrome is a congenital eye movement disorder characterized by congenital malformation of the abducens nucleus. Thrombogenic conditions during development may lead to vascular anomalies in Duane syndrome, however, the presence of a giant aneurysm in this patient population is a rarely documented phenomenon. CASE DESCRIPTION: We reported a case of a large cerebral aneurysm in a pediatric patient with Duane syndrome, and performed a review of the literatures to identify other potential cases and associations...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29777786/photoselective-vaporisation-of-the-bladder-for-the-management-of-radiation-cystitis-technique-and-initial-outcomes
#18
Claire Pascoe, Daniel Christidis, Todd Manning, Benjamin W Lamb, Declan G Murphy, Nathan Lawrentschuk
Objective To describe our technique utilising photoselective vaporisation of the bladder (PVB) for the management of haemorrhagic cystitis and initial results of 12 patients. Materials and Method An audit of theatre records of a single surgeon was performed to identify patients who had undergone PVB for management of radiation-cystitis. TECHNIQUE: Rigid cystoscopy was performed. Ureteric catheters were placed and active bleeding sites targeted to optimise vision. Ablation was commenced using the vaporize function...
May 16, 2018: Urology
https://www.readbyqxmd.com/read/29777707/functional-analysis-of-juxta-and-intra-membrane-domains-of-murine-app-by-genome-editing-in-neuro2a-cells
#19
Nanaka Kaneshiro, Ryosuke Imaoka, Masato Komai, Taku Kashiyama, Takashi Sakurai, Takashi Uehara, Nobumasa Takasugi
Amyloid-β precursor protein (APP) correlates with the pathogenesis of certain brain diseases, such as Alzheimer disease (AD). APP is cleaved by several enzymes to produce APP metabolites, including the amyloid beta peptide (Aβ), which accumulates in the brain of AD patients. However, the exact functions of APP metabolites remain elusive. In this study, using genome editing technology, we mutated juxta- and intra-membrane domains of murine APP in the mouse neuroblastoma cell line, Neuro2a. We identified several clones that expressed characteristic patterns of APP metabolites...
May 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29777681/electrochemical-enzymatic-fenitrothion-sensor-based-on-a-tyrosinase-poly-2-hydroxybenzamide-modified-graphite-electrode
#20
Maria de Fátima Alves, Ricardo Augusto Moreira de Souza Corrêa, Filipe Soares da Cruz, Diego Leoni Franco, Lucas Franco Ferreira
This paper reports the electrosynthesis and characterisation of a polymeric film derived from 2-hydroxybenzamide over a graphite electrode and its application as an enzymatic biosensor for the determination and quantification of the pesticide fenitrothion. The material was analysed by scanning electron microscopy and its electrochemical properties characterised by cyclic voltammetry and electrochemical impedance spectroscopy. The enzyme tyrosinase was immobilised over the modified electrode by the drop and dry technique...
May 16, 2018: Analytical Biochemistry
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