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myo-inositol pcos normal weight

Alessandro D Genazzani, Susanna Santagni, Federica Ricchieri, Annalisa Campedelli, Erika Rattighieri, Elisa Chierchia, Giulia Marini, Giulia Despini, Alessia Prati, Tommaso Simoncini
AIM: To investigate hormonal dynamics in a group of non-obese polycystic ovary syndrome (PCOS) patients under myo-inositol (MYO) administration. METHODS: Hormonal profiles, insulin response to oral glucose tolerance test (OGTT) and luteinizing hormone (LH) response to gonadotropin-releasing hormone (GnRH) stimulation test before and after the administration of a preparation of MYO (3 g p.o. daily) mixed with lactoferrin and bromelin, in a group (n = 24) of normal weight PCOS patients...
May 2014: Journal of Obstetrics and Gynaecology Research
Gabriella DonĂ , Chiara Sabbadin, Cristina Fiore, Marcantonio Bragadin, Francesco L Giorgino, Eugenio Ragazzi, Giulio Clari, Luciana Bordin, Decio Armanini
OBJECTIVE: Possibly due to a deficiency of insulin mediators, polycystic ovary syndrome (PCOS) is often associated with insulin resistance (IR) and hyperinsulinemia, likely responsible for an elevated production of reactive oxygen species. We investigated oxidative-related alterations in erythrocytes and anti-inflammatory effects of inositol in women with PCOS before and after treatment with myo-inositol (MYO). METHODS: Twenty-six normal-weight PCOS patients were investigated before and after MYO administration (1200 mg/day for 12 weeks; n=18) or placebo (n=8) by evaluating serum testosterone, serum androstenedione, fasting serum insulin, fasting serum glucose, insulin area under the curve (AUC), and glucose AUC after oral glucose tolerance test and homeostasis model of assessment-IR...
April 2012: European Journal of Endocrinology
S Gerli, E Papaleo, A Ferrari, G C Di Renzo
Oligomenorrhea and polycystic ovaries in women are one of the most important causes of the high incidence of ovulation failure. This is linked, perhaps, to insulin resistance and related metabolic features. A small number of reports show that myo-inositol improves ovarian function, but in these trials the quality of evidence supporting ovulation is suboptimal. Furthermore, few of them have been placebo-controlled. The aim of our study was to use a double-blind, placebo-controlled approach with detailed assessment of ovarian activity (two blood samples per week) to assess the validity of this therapeutic approach in this group of women...
September 2007: European Review for Medical and Pharmacological Sciences
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