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Transcriptional regulation

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https://www.readbyqxmd.com/read/29906815/review-endoplasmic-reticulum-associated-degradation-erad-dependent-control-of-tri-terpenoid-metabolism-in-plants
#1
Marie-Laure Erffelinck, Alain Goossens
Plants are sessile organisms. Therefore, they developed the capacity to quickly respond to biotic and abiotic environmental stresses, for instance by producing a broad spectrum of bioactive specialized metabolites. In this defense response, the jasmonate phytohormones can instigate a signaling cascade that leads to the specific elicitation and reprograming of numerous metabolic pathways. Recent research progress has provided several insights into the regulatory networks of many specialized metabolic pathways, mainly at the transcriptional level...
June 15, 2018: Planta Medica
https://www.readbyqxmd.com/read/29906777/synergetic-effects-of-5-aminolevulinic-acid-and-ascophyllum-nodosum-seaweed-extracts-on-asparagus-phenolics-and-stress-related-genes-under-saline-irrigation
#2
Abdullah A Al-Ghamdi, Hosam O Elansary
Salinity is one of the major agricultural problems that may threat food security and limit the agricultural lands expansion worldwide. Exploring novel tools controlling saline conditions and increase valuable secondary metabolites in the horticultural crops might have outstanding results that serve humanity in the current century. The current study explores the effects of weekly seaweed extracts (7 mL  L-1 ) and/or 5-aminolevulinic acid (3, 5 and 10 ppm) sprays on Asparagus aethiopicus plants subjected to saline stress conditions (2000 and 4000 ppm) for 6 weeks in two consecutive seasons of 2016 and 2017...
June 9, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29906776/paenibacillus-pabuli-strain-p7s-promotes-plant-growth-and-induces-anthocyanin-accumulation-in-arabidopsis-thaliana
#3
Cao Son Trinh, Chan Young Jeong, Won Je Lee, Hai An Truong, Namhyun Chung, Juhyeong Han, Suk-Whan Hong, Hojoung Lee
In this study, a novel plant growth-promoting rhizobacteria (PGPR), the bacterial strain Paenibacillus pabuli P7S (PP7S), showed promising plant growth-promoting effects. Furthermore, it induced anthocyanin accumulation in Arabidopsis. When co-cultivated with PP7S, there was a significant increase in anthocyanin content and biomass of Arabidopsis seedlings compared with those of the control. The quantitative reverse transcription-polymerase chain reaction analysis revealed higher expression of many key genes regulating anthocyanin and flavonoid biosynthesis pathways in PP7S-treated seedlings when compared with that of the control...
June 1, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29906775/indole-3-acetic-acid-modulates-phytohormones-and-polyamines-metabolism-associated-with-the-tolerance-to-water-stress-in-white-clover
#4
Zhou Li, Yaping Li, Yan Zhang, Bizhen Cheng, Yan Peng, Xinquan Zhang, Xiao Ma, Linkai Huang, Yanhong Yan
Endogenous hormones and polyamines (PAs) could interact to regulate growth and tolerance to water stress in white clover. The objective of this study was to investigate whether the alteration of endogenous indole-3-acetic acid (IAA) level affected other hormones level and PAs metabolism contributing to the regulation of tolerance to water stress in white clover. Plants were pretreated with IAA or L-2-aminooxy-3-phenylpropionic acid (L-AOPP, the inhibitor of IAA biosynthesis) for 3 days and then subjected to water-sufficient condition and water stress induced by 15% polyethylene glycol 6000 for 8 days in growth chambers...
June 9, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29906744/microrna-302c-represses-epithelial-mesenchymal-transition-and-metastasis-by-targeting-transcription-factor-ap-4-in-colorectal-cancer
#5
Wenqi Ma, Bailing Liu, Jie Li, Jue Jiang, Ru Zhou, Lili Huang, Xiaopeng Li, Xin He, Qi Zhou
MicroRNAs (miRNAs) contribute to tumorigenesis and progression via acting as tumor suppressors or oncogenes in human cancer. Aberrant expression of miR-302c has been reported in various types of cancer except colorectal cancer (CRC). Thus, our study was aimed to verify the expression of miR-302c and its functional role in CRC. We found a significant reduced expression of miR-302c in CRC tissues compared to tumor-adjacent tissues. Low miR-302c level was remarkably correlated with deeper tumor invasion, lymph node metastasis and advanced TNM stage...
June 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29906534/anti-inflammatory-effect-of-low-molecular-weight-fucoidan-from-saccharina-japonica-on-atherosclerosis-in-apoe-knockout-mice
#6
Yingjie Xu, Jie Xu, Keli Ge, Qingwu Tian, Peng Zhao, Yunliang Guo
Atherosclerosis (AS) is the key cause of many cardiovascular and cerebrovascular diseases. The inflammatory response and lipid metabolism disorders contribute to the development and progression of AS. This work aims to study the anti-inflammatory effect and mechanism of low molecular weight fucoidan (LMWF) obtained from Saccharina japonica on atherosclerosis in apoE-knockout mice. The experimental results showed that LMWF statistically decreased the levels of triglyceride (TRIG) and oxidative low-density lipoproteins (ox-LDL) and stabilized established atherosclerotic lesions...
June 12, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29906497/translational-regulation-is-a-key-determinant-of-the-cellular-response-to-benzo-a-pyrene
#7
Evelyn Smit, Florian Caiment, Jolanda Piepers, Jos C S Kleinjans, Twan van den Beucken
Translational control is a cellular response mechanism which initiates adaptation during various stress situations. Here, we investigated the role of translational control after benzo[a]pyrene (BaP) exposure in primary mouse hepatocytes. Translated mRNAs were separated and captured based on the number of associated ribosomes using sucrose gradients and subjected to RNA sequencing (RNAseq) to investigate translational changes. Furthermore, unseparated RNA (total RNA) was used for RNAseq to determine the transcriptional alterations...
June 12, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29906485/deciphering-brain-specific-transcriptomic-expression-of-ezr-rad-and-msn-genes-in-the-development-of-mus-musculus
#8
Syed Aoun Ali, Deeba N Baig
Ezrin, Radixin and Moesin (ERM) are critical membranous component involved in cross-linking of actin filaments. Moesin (Msn) is recognized as a pivotal protein involved in regulation of cell signalling events associated with the maintenance of epithelial integrity, actin organization and polarity. Radixin (Rad) is known to cell-to-cell adherens junction as a barbed end-capping protein whereas ezrin (Ezr) is recognized at cell adhesion, motility, apoptosis and phagocytosis. The current study for the first time reports the transcriptional and RNA secondary structural variations among brain-specific ERM genes...
June 12, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29906451/mfd-dynamically-regulates-transcription-via-a-release-and-catch-up-mechanism
#9
Tung T Le, Yi Yang, Chuang Tan, Margaret M Suhanovsky, Robert M Fulbright, James T Inman, Ming Li, Jaeyoon Lee, Sarah Perelman, Jeffrey W Roberts, Alexandra M Deaconescu, Michelle D Wang
No abstract text is available yet for this article.
June 14, 2018: Cell
https://www.readbyqxmd.com/read/29906271/genome-wide-characterization-and-expression-analysis-of-citrus-nuclear-factor-y-nf-y-transcription-factors-identified-a-novel-nf-ya-gene-involved-in-drought-stress-response-and-tolerance
#10
Suzam L S Pereira, Cristina P S Martins, Aurizangela O Sousa, Luciana R Camillo, Caroline P Araújo, Grazielle M Alcantara, Danielle S Camargo, Luciana C Cidade, Alex-Alan F de Almeida, Marcio G C Costa
Nuclear factor Y (NF-Y) is a ubiquitous transcription factor found in eukaryotes. It is composed of three distinct subunits called NF-YA, NF-YB and NF-YC. NF-Ys have been identified as key regulators of multiple pathways in the control of development and tolerance to biotic and abiotic factors. The present study aimed to identify and characterize the complete repertoire of genes coding for NF-Y in citrus, as well as to perform the functional characterization of one of its members, namely CsNFYA5, in transgenic tobacco plants...
2018: PloS One
https://www.readbyqxmd.com/read/29906249/aberrant-mir-145-5p-%C3%AE-catenin-signal-impairs-osteocyte-function-in-adolescent-idiopathic-scoliosis
#11
Jiajun Zhang, Huanxiong Chen, Ross K K Leung, Kwong Wai Choy, Tsz-Ping Lam, Bobby K W Ng, Yong Qiu, Jian Q Feng, Jack C Y Cheng, Wayne Y W Lee
Recently, noncoding RNAs have been thought to play important roles in the sporadic occurrence of spinal deformity of adolescent idiopathic scoliosis (AIS). As a prognostic factor for curve progression, low bone mass has been hypothesized to crosstalk with AIS pathogenesis. Abnormal osteoblasts activities are reported in AIS without a clear mechanism. In this study, bone biopsies from patients with AIS and control subjects and the primary osteoblasts derived from those samples were used to identify the potential microRNA (miRNA) candidates that interfere with osteoblasts and osteocytes function...
June 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29906245/the-gut-microbiota-metabolite-indole-alleviates-liver-inflammation-in-mice
#12
Martin Beaumont, Audrey M Neyrinck, Marta Olivares, Julie Rodriguez, Audrey de Rocca Serra, Martin Roumain, Laure B Bindels, Patrice D Cani, Pieter Evenepoel, Giulio G Muccioli, Jean-Baptiste Demoulin, Nathalie M Delzenne
The gut microbiota regulates key hepatic functions, notably through the production of bacterial metabolites that are transported via the portal circulation. We evaluated the effects of metabolites produced by the gut microbiota from aromatic amino acids (phenylacetate, benzoate, p-cresol, and indole) on liver inflammation induced by bacterial endotoxin. Precision-cut liver slices prepared from control mice, Kupffer cell (KC)-depleted mice, and obese mice ( ob/ ob) were treated with or without LPS and bacterial metabolites...
June 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29906231/role-of-endothelial-microrna-23-clusters-in-angiogenesis-in-vivo
#13
Satoshi Oikawa, Shogo Wada, Minjung Lee, Seiji Maeda, Takayuki Akimoto
The capillary network is distributed throughout the body, and its reconstruction is induced under various pathophysiological conditions. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression via post-transcriptional mechanisms and are involved in many biological functions including angiogenesis. Previous studies have shown that each miRNA of the miR-23 cluster, composed of the miR-23a cluster (miR-23a~27a~24-2) and miR-23b cluster (miR-23b~27b~24-2), regulates angiogenesis in vitro. However, the role of the endothelium-specific miR-23 cluster, located within a single transcription unit, in angiogenesis in vivo has not been elucidated...
June 15, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29906225/scleraxis-regulates-twist1-and-snai1-expression-in-epithelial-to-mesenchymal-transition
#14
Danah S Al-Hattab, Hamza A Safi, Raghu S Nagalingam, Rushita A Bagchi, Matthew Taras Stecy, Michael Paul Czubryt
Numerous physiological and pathological events, from organ development to cancer and fibrosis, are characterized by Epithelial-to-Mesenchymal Transition (EMT), whereby adherent epithelial cells convert to migratory mesenchymal cells. During cardiac development, pro-epicardial organ epithelial cells undergo EMT to generate fibroblasts. Subsequent stress or damage induces further phenotype conversion of fibroblasts to myofibroblasts, causing fibrosis via synthesis of excessive extracellular matrix. We previously showed that the transcription factor scleraxis is both sufficient and necessary for the conversion of cardiac fibroblasts to myofibroblasts, and found that scleraxis knockout reduced cardiac fibroblast number by 50%, possibly via EMT attenuation...
June 15, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29906208/feed-efficient-pigs-exhibit-molecular-patterns-allowing-a-timely-circulation-of-hormones-and-nutrients
#15
Henry Reyer, Michael Oster, Elizabeth Magowan, Eduard Murani, Helga Sauerwein, Dirk Dannenberger, Björn Kuhla, Siriluck Ponsuksili, Klaus Wimmers
Feed efficiency (FE) is a measure of the rate between feed intake and body weight gain and is subject to constant progress in pigs, based on extensive performance tests and analyses of physiological parameters. However, endocrine regulatory circuits which comprise the sensation and perception of intrinsic requirements and appropriate systemic responses have not yet been fully elucidated. It is hypothesized that the gut-brain-axis, which is a network of hierarchical anterior regulatory tissues, contributes largely to variations in FE...
June 15, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29905975/the-grk2-promoter-is-regulated-by-early-growth-response-transcription-factor-egr-1
#16
Stefanie Klenke, Andrea Engler, Daniel Ecker, Crista Ochsenfarth, Nina Danowski, Jürgen Peters, Winfried Siffert, Ulrich H Frey
The G-protein-coupled receptor kinase 2 (GRK2) plays a major role in cardiovascular diseases and its expression is increased in heart failure. However, only little is known about factors being involved in up-regulation of GRK2 expression through transcriptional regulation of its promoter. Since the transcription factor early-growth response 1 (EGR-1) is also up-regulated in patients with heart failure, we tested the hypothesis that EGR-1 regulates GRK2 transcription. Stimulation of immortalized rat cardiomyocytes (H9c2) with phorbol 12-myristate 13-acetate (PMA) resulted in up-regulation of Egr-1 and subsequently of Grk2 mRNA expression, with maximum Grk2 expression (p=0...
June 15, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29905892/physiological-and-unappreciated-roles-of-camkii-in-the-heart
#17
REVIEW
Jan Beckendorf, Maarten M G van den Hoogenhof, Johannes Backs
In the cardiomyocyte, CaMKII has been identified as a nodal influencer of excitation-contraction and also excitation-transcription coupling. Its activity can be regulated in response to changes in intracellular calcium content as well as after several post-translational modifications. Some of the effects mediated by CaMKII may be considered adaptive, while effects of sustained CaMKII activity may turn into the opposite and are detrimental to cardiac integrity and function. As such, CaMKII has long been noted as a promising target for pharmacological inhibition, but the ubiquitous nature of CaMKII has made it difficult to target CaMKII specifically where it is detrimental...
June 15, 2018: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29905868/casein-kinase-2-mediated-phosphorylation-of-spt6-modulates-histone-dynamics-and-regulates-spurious-transcription
#18
Emmanuelle Gouot, Wajid Bhat, Anne Rufiange, Eric Fournier, Eric Paquet, Amine Nourani
CK2 is an essential protein kinase implicated in various cellular processes. In this study, we address a potential role of this kinase in chromatin modulations associated with transcription. We found that CK2 depletion from yeast cells leads to replication-independent increase of histone H3K56 acetylation and global activation of H3 turnover in coding regions. This suggests a positive role of CK2 in maintenance/recycling of the histone H3/H4 tetramers during transcription. Interestingly, strand-specific RNA-seq analyses show that CK2 inhibits global cryptic promoters driving both sense and antisense transcription...
June 14, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29905862/building-a-schizophrenia-genetic-network-transcription-factor-4-regulates-genes-involved-in-neuronal-development-and-schizophrenia-risk
#19
Hanzhang Xia, Fay M Jahr, Nak-Kyeong Kim, Linying Xie, Andrey A Shabalin, Julien Bryois, Douglas H Sweet, Mohamad M Kronfol, Preetha Palasuberniam, MaryPeace McRae, Brien P Riley, Patrick F Sullivan, Edwin J van den Oord, Joseph L McClay
The transcription factor 4 (TCF4) locus is a robust association finding with schizophrenia (SCZ), but little is known about the genes regulated by the encoded transcription factor. Therefore, we conducted chromatin immunoprecipitation sequencing (ChIP-seq) of TCF4 in neural-derived (SH-SY5Y) cells to identify genome-wide TCF4 binding sites, followed by data integration with SCZ association findings. We identified 11,322 TCF4 binding sites overlapping in two ChIP-seq experiments. These sites are significantly enriched for the TCF4 Ebox binding motif (>85% having ≥1 Ebox) and implicate a gene set enriched for genes down-regulated in TCF4 siRNA knockdown experiments, indicating the validity of our findings...
June 14, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29905849/identification-and-characterization-of-novel-conserved-domains-in-metazoan-zic-proteins
#20
Takahide Tohmonda, Akiko Kamiya, Akira Ishiguro, Takashi Iwaki, Takahiko J Fujimi, Minoru Hatayama, Jun Aruga
Zic family genes encode C2H2-type zinc finger proteins that act as critical toolkit proteins in the metazoan body plan establishment. In this study, we searched evolutionarily conserved domains among 121 Zic protein sequences from 22 animal phyla and 40 classes, and addressed their evolutionary significance. The collected sequences included those from poriferans and orthonectids. We discovered seven new conserved domains (CDs), CD0-CD6, (in order from the N- to C-terminus) using the most conserved Zic protein sequences from Deuterostomia (Hemichordata, Cephalochordata), Lophotrochozoa (Cephalopoda and Brachiopoda), and Ecdysozoa (Chelicerata, Priapulida)...
June 14, 2018: Molecular Biology and Evolution
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