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Firoz Ahmad, Rupa Dalvi, Bibhu Ranjan Das, Swarna Mandava
BACKGROUND: Acute myeloid leukemia (AML) is a heterogeneous disease with regard to morphology, immunophenotype, and genetic rearrangements. Multiple recurrent chromosomal aberrations have been identified by conventional cytogenetic analysis, which is now widely recognized as one of the most important diagnostic and prognostic determinants in AML. METHOD: Conventional cytogenetic analysis was done on 200 de novo AML subjects. RESULTS: Of these, 176 (88%) were successfully karyotyped and 24 (12%) showed culture failure...
2008: Cancer Detection and Prevention
Liming Bao, Xiaoqin Wang, John Ryder, Meirong Ji, Yan Chen, Hui Chen, Hengjuan Sun, Yongchen Yang, Xinyu Du, Patrick Kerzic, Sherilyn A Gross, Lihong Yao, Ling Lv, Hua Fu, Guowei Lin, Richard D Irons
We report a prospective study of 174 unselected adult de novo acute myeloid leukemia (AML) cases diagnosed using the WHO classification. Of those, 57 (33%) were AML with recurrent cytogenetic abnormalities, 41 were (24%) AML with multilineage dysplasia, 74 (42%) were AML not otherwise categorized, and two were acute leukemias of ambiguous lineage. Clonal cytogenetic abnormalities were detected in 64% of the WHO AML cases with t(15;17) (15%), t(8;21) (12%), +8 (11%), -7/del7q (8%) and del9q (5%) being the most common ones...
July 2006: European Journal of Haematology
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