Chao Li, Wei Wang, Shuai-Shuai Xie, Wen-Xian Ma, Qian-Wen Fan, Ying Chen, Yuan He, Jia-Nan Wang, Qin Yang, Hai-di Li, Juan Jin, Ming-Ming Liu, Xiao-Ming Meng, Jia-Gen Wen
Sepsis is a systemic inflammatory response syndrome caused by infection, following with acute injury to multiple organs. Sepsis-induced acute kidney injury (AKI) is currently recognized as one of the most severe complications related to sepsis. The pathophysiology of sepsis-AKI involves multiple cell types, including macrophages, vascular endothelial cells (ECs) and renal tubular epithelial cells (TECs), etc. More significantly, programmed cell death including apoptosis, necroptosis and pyroptosis could be triggered by sepsis in these types of cells, which enhances AKI progress...
2021: Frontiers in Medicine