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https://www.readbyqxmd.com/read/27773452/significant-role-for-microrna-21-affecting-toll-like-receptor-pathway-in-primary-graft-dysfunction-after-human-lung-transplantation
#1
Zhongping Xu, Monal Sharma, Andrew Gelman, Ramsey Hachem, Thalachallour Mohanakumar
BACKGROUND: MicroRNAs (miRNAs) were recently identified as modulators of immune responses after human lung transplantation (LTx). This study was undertaken to assess the contribution of miRNAs to the pathogenesis of primary graft dysfunction (PGD) after LTx. METHODS: Of the 39 recipients, 14 (35.9%) developed Grade 3 PGD (i.e., severe PGD) within the first 72 hours of LTx. The remaining 25 recipients (64.1%) had Grade 2 or less PGD, and served as the control group...
September 12, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27698401/confirmation-of-an-irak3-polymorphism-as-a-genetic-marker-predicting-response-to-anti-tnf-treatment-in-rheumatoid-arthritis
#2
J Sode, U Vogel, S Bank, P S Andersen, M L Hetland, H Locht, N H H Heegaard, V Andersen
Several genetic variants in Toll-like receptor (TLR) and nuclear factor (NF)-κB signalling pathways have been reported associated with responsiveness to tumour necrosis factor inhibitor (anti-TNF) treatment in rheumatoid arthritis (RA). The present study was undertaken to replicate these findings. In a retrospective case-case study including 1007 Danish anti-TNF-treated RA patients, we genotyped 7 previously reported associated single-nucleotide polymorphisms (SNPs) in these pathways. Furthermore, 5 SNPs previously reported by our group were genotyped in a subcohort (N=469)...
October 4, 2016: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/27260481/inflammasome-and-toll-like-receptor-signaling-in-human-monocytes-after-successful-cardiopulmonary-resuscitation
#3
Alexander Asmussen, Katrin Fink, Hans-Jörg Busch, Thomas Helbing, Natascha Bourgeois, Christoph Bode, Sebastian Grundmann
BACKGROUND: Whole body ischemia-reperfusion injury (IRI) after cardiopulmonary resuscitation (CPR) induces a generalized inflammatory response which contributes to the development of post-cardiac arrest syndrome (PCAS). Recently, pattern recognition receptors (PRRs), such as toll-like receptors (TLRs) and inflammasomes, have been shown to mediate the inflammatory response in IRI. In this study we investigated monocyte PRR signaling and function in PCAS. METHODS: Blood samples were drawn in the first 12 hours, and at 24 and 48 hours following return of spontaneous circulation in 51 survivors after cardiac arrest...
2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/26956052/survival-kinase-genes-present-prognostic-significance-in-glioblastoma
#4
Robin T Varghese, Yanping Liang, Ting Guan, Christopher T Franck, Deborah F Kelly, Zhi Sheng
Cancer biomarkers with a strong predictive power for diagnosis/prognosis and a potential to be therapeutic targets have not yet been fully established. Here we employed a loss-of-function screen in glioblastoma (GBM), an infiltrative brain tumor with a dismal prognosis, and identified 20 survival kinase genes (SKGs). Survival analyses using The Cancer Genome Atlas (TCGA) datasets revealed that the expression of CDCP1, CDKL5, CSNK1E, IRAK3, LATS2, PRKAA1, STK3, TBRG4, and ULK4 stratified GBM prognosis with or without temozolomide (TMZ) treatment as a covariate...
April 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/26847702/impairing-autophagy-in-retinal-pigment-epithelium-leads-to-inflammasome-activation-and-enhanced-macrophage-mediated-angiogenesis
#5
Jian Liu, David A Copland, Sofia Theodoropoulou, Hsi An Amy Chiu, Miriam Durazo Barba, Ka Wang Mak, Matthias Mack, Lindsay B Nicholson, Andrew D Dick
Age-related decreases in autophagy contribute to the progression of age-related macular degeneration (AMD). We have now studied the interaction between autophagy impaired in retinal pigment epithelium (RPE) and the responses of macrophages. We find that dying RPE cells can activate the macrophage inflammasome and promote angiogenesis. In vitro, inhibiting rotenone-induced autophagy in RPE cells elicits caspase-3 mediated cell death. Co-culture of damaged RPE with macrophages leads to the secretion of IL-1β, IL-6 and nitrite oxide...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26642921/micrornas-regulators-of-tlr2-mediated-probiotic-immune-responses
#6
Anna González-Rascón, Verónica Mata-Haro
MicroRNAs (miRNAs) are similar in importance to transcription factors and critical to confer accuracy and robustness in gene expression programs and consequently, have emerged as controllers of the immune response. On the other hand, probiotic influence over immune responses against a wide spectrum of health conditions are widely studied but the mechanism for this modulation has not yet completely elucidated. One proposed mechanism involves the receptor-mediated interaction of dendritic cells with components of the cellular membrane and/or secreted peptides of probiotics ending with the production of cytokines...
2015: MicroRNA
https://www.readbyqxmd.com/read/26551297/development-of-castration-resistant-prostate-cancer-can-be-predicted-by-a-dna-hypermethylation-profile
#7
Javier C Angulo, Guillermo Andrés, Nadia Ashour, Manuel Sánchez-Chapado, Jose I López, Santiago Ropero
PURPOSE: Detection of DNA hypermethylation has emerged as a novel molecular biomarker for prostate cancer diagnosis and evaluation of prognosis. We sought to define whether a hypermethylation profile of patients with prostate cancer on androgen deprivation would predict castrate resistant prostate cancer. MATERIALS AND METHODS: Genome-wide methylation analysis was performed using a methylation cancer panel in 10 normal prostates and 45 tumor samples from patients placed on androgen deprivation who were followed until castrate resistant disease developed...
March 2016: Journal of Urology
https://www.readbyqxmd.com/read/26473437/effects-of-sequence-variations-in-innate-immune-response-genes-on-infectious-outcome-in-trauma-patients-a-comprehensive-review
#8
REVIEW
Maarten W G A Bronkhorst, Peter Patka, Esther M M Van Lieshout
Infectious complications, sepsis, and multiple organ dysfunction syndrome (MODS) remain important causes for morbidity and mortality in patients who survive the initial trauma. Increasing evidence suggests that genetic variants, particularly single nucleotide polymorphisms (SNPs), are critical determinants for interindividual differences in both inflammatory responses and clinical outcome in sepsis patients. Although the effect of SNPs on sepsis and MODS has been studied in many populations and diseases, this review aimed to summarize the current knowledge on the effect of SNPs on infectious complication specifically in trauma patients...
November 2015: Shock
https://www.readbyqxmd.com/read/26280733/progesterone-and-the-repression-of-myometrial-inflammation-the-roles-of-mkp-1-and-the-ap-1-system
#9
K Lei, E X Georgiou, L Chen, A Yulia, S R Sooranna, J J Brosens, P R Bennett, M R Johnson
Progesterone (P4) maintains uterine quiescence during pregnancy and its functional withdrawal is associated with increased prostaglandin synthesis and the onset of labor. In primary human myometrial cells, the glucocorticoid receptor (GR) rather than the P4 receptor mediates P4 antagonism of IL-1β-induced cyclooxygenase-2 (COX-2) expression, the rate-limiting enzyme in prostaglandin synthesis. We now report that P4 also acts via GR to induce MAPK phosphatase (MKP)-1 and knockdown of MKP-1 impairs the ability of P4 to repress IL-1β-dependent COX-2 induction...
October 2015: Molecular Endocrinology
https://www.readbyqxmd.com/read/26099328/identification-and-expression-analysis-of-irak1-gene-in-common-carp-cyprinus-carpio-l-indications-for-a-role-of-antibacterial-and-antiviral-immunity
#10
S J Shan, D Z Liu, L Wang, Y Y Zhu, F M Zhang, T Li, L G An, G W Yang
In this study, the full-length complementary (c)DNA of interleukin-1 receptor-associated kinase 1 gene (irak1) was cloned from common carp Cyprinus carpio. The complete open reading frame of irak1 contained 2109 bp encoding a protein of 702 amino acid residues that comprised a death domain, a ProST region, a serine-threonine-specific protein kinase catalytic domain and a C-terminal domain. The amino-acid sequence of C. carpio Irak1 protein shared sequence homology with grass carp Ctenopharyngodon idellus (84...
August 2015: Journal of Fish Biology
https://www.readbyqxmd.com/read/26025919/assessment-and-diagnostic-relevance-of-novel-serum-biomarkers-for-early-decision-of-st-elevation-myocardial-infarction
#11
Hun-Jun Park, Ji Heon Noh, Jung Woo Eun, Yoon-Seok Koh, Suk Min Seo, Won Sang Park, Jung Young Lee, Kiyuk Chang, Ki Bae Seung, Pum-Joon Kim, Suk Woo Nam
Blood transcriptome reflects the status of diseases, and characteristic molecular signature provides a novel window on gene expression preceding acute coronary events. We aim to determine blood transcriptome-based molecular signature of acute coronary syndrome (ACS), and to identify novel serum biomarkers for early stage ST-segment-elevation myocardial infarction (STEMI). We obtained peripheral blood from the patients with ACS who visited emergency department within 4 hours after the onset of chest pain: STEMI (n = 10), Non-ST-segment-elevation MI (NSTEMI, n = 10) and unstable angina (UA, n = 11)...
May 30, 2015: Oncotarget
https://www.readbyqxmd.com/read/25852282/methylation-of-irak3-is-a-novel-prognostic-marker-in-hepatocellular-carcinoma
#12
Chih-Chi Kuo, Yu-Lueng Shih, Her-Young Su, Ming-De Yan, Chung-Bao Hsieh, Chin-Yu Liu, Wei-Ting Huang, Mu-Hsien Yu, Ya-Wen Lin
AIM: To examine the methylation levels of interleukin-1 receptor-associated kinase 3 (IRAK3) and GLOXD1 and their potential clinical applications in hepatocellular carcinoma (HCC). METHODS: mRNA expression and promoter methylation of IRAK3 and GLOXD1 in HCC cells were analyzed by reverse transcription-polymerase chain reaction (RT-PCR) and methylation-specific PCR (MSP), respectively. Using pyrosequencing results, we further established a quantitative MSP (Q-MSP) system for the evaluation of IRAK3 and GLOXD1 methylation in 29 normal controls and 160 paired HCC tissues and their adjacent nontumor tissues...
April 7, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25399605/comparison-of-moonlighting-guanylate-cyclases-roles-in-signal-direction
#13
REVIEW
Lubna Freihat, Victor Muleya, David T Manallack, Janet I Wheeler, Helen R Irving
Over 30 receptor-like kinases contain a guanylate cyclase (GC) catalytic centre embedded within the C-terminal region of their kinase domain in the model plant Arabidopsis. A number of the kinase GCs contain both functional kinase and GC activity in vitro and the natural ligands of these receptors stimulate increases in cGMP within isolated protoplasts. The GC activity could be described as a minor or moonlighting activity. We have also identified mammalian proteins that contain the novel GC centre embedded within kinase domains...
December 2014: Biochemical Society Transactions
https://www.readbyqxmd.com/read/25069573/transcriptional-profiling-of-peripheral-blood-in-pancreatic-adenocarcinoma-patients-identifies-diagnostic-biomarkers
#14
Octavio Caba, Jose Prados, Raúl Ortiz, Cristina Jiménez-Luna, Consolación Melguizo, Pablo J Alvarez, Juan R Delgado, Antonio Irigoyen, Ignacio Rojas, Javier Pérez-Florido, Carolina Torres, Sonia Perales, Ana Linares, Antonia Aránega
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy associated with poor survival rates. Fast detection of PDAC appears to be the most relevant strategy to improve the long-term survival of patients. AIMS: Our objective was to identify new markers in peripheral blood that differentiates between PDAC patients and healthy controls. METHODS: Peripheral blood samples from PDAC patients (n = 18) and controls (n = 18) were analyzed by whole genome cDNA microarray hybridization...
November 2014: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/24815918/gene-expression-profile-induced-by-ovariectomy-in-bone-marrow-of-mice-a-functional-approach-to-identify-new-candidate-genes-associated-to-osteoporosis-risk-in-women
#15
Begoña Pineda, Eva Serna, Andrés Laguna-Fernández, Inmaculada Noguera, Layla Panach, Carlos Hermenegildo, Juan J Tarín, Antonio Cano, Miguel Ángel García-Pérez
Osteoporosis is a multifactorial skeletal pathology with a main genetic component. To date, however, the majority of genes associated with this pathology remain unknown since genes cataloged to date only explain a part of the heritability of bone phenotypes. In the present study, we have used a genome-wide gene expression approach by means of microarrays to identify new candidate genes involved in the physiopathology of osteoporosis, using as a model the ovariectomized (OVX) mice by comparing global bone marrow gene expression of the OVX mice with those of SHAM operated mice...
August 2014: Bone
https://www.readbyqxmd.com/read/24792928/pkc%C3%AE-irak1-axis-regulates-oxidized-ldl-induced-il-1%C3%AE-production-in-monocytes
#16
Rajiv Lochan Tiwari, Vishal Singh, Ankita Singh, Minakshi Rana, Anupam Verma, Nikhil Kothari, Monica Kohli, Jaishri Bogra, Madhu Dikshit, Manoj Kumar Barthwal
This study examined the role of interleukin (IL)-1 receptor-associated kinase (IRAK) and protein kinase C (PKC) in oxidized LDL (Ox-LDL)-induced monocyte IL-1β production. In THP1 cells, Ox-LDL induced time-dependent secretory IL-1β and IRAK1 activity; IRAK4, IRAK3, and CD36 protein expression; PKCδ-JNK1 phosphorylation; and AP-1 activation. IRAK1/4 siRNA and inhibitor (INH)-attenuated Ox-LDL induced secreted IL-1β and pro-IL-1β mRNA and pro-IL-1β and mature IL-1β protein expression, respectively. Diphenyleneiodonium chloride (NADPH oxidase INH) and N-acetylcysteine (free radical scavenger) attenuated Ox-LDL-induced reactive oxygen species generation, caspase-1 activity, and pro-IL-1β and mature IL-1β expression...
July 2014: Journal of Lipid Research
https://www.readbyqxmd.com/read/24721645/blood-mrna-expression-profiling-predicts-survival-in-patients-treated-with-tremelimumab
#17
MULTICENTER STUDY
Yvonne Saenger, Jay Magidson, Bobby Liaw, Ellen de Moll, Sara Harcharik, Yichun Fu, Karl Wassmann, David Fisher, John Kirkwood, William K Oh, Philip Friedlander
PURPOSE: Tremelimumab (ticilimumab, Pfizer), is a monoclonal antibody (mAb) targeting cytotoxic T lymphocyte-associated antigen-4 (CTLA-4). Ipilimumab (Yervoy, BMS), another anti-CTLA-4 antibody, is approved by the U.S. Federal Drug Administration (FDA). Biomarkers are needed to identify the subset of patients who will achieve tumor control with CTLA-4 blockade. EXPERIMENTAL DESIGN: Pretreatment peripheral blood samples from 218 patients with melanoma who were refractory to prior therapy and receiving tremelimumab in a multicenter phase II study were measured for 169 mRNA transcripts using reverse transcription polymerase chain reaction (RT-PCR)...
June 15, 2014: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/24681432/frequent-methylation-of-hoxa9-gene-in-tumor-tissues-and-plasma-samples-from-human-hepatocellular-carcinomas
#18
Chih-Chi Kuo, Ching-Yu Lin, Yu-Lueng Shih, Chung-Bao Hsieh, Pei-Yu Lin, Shuh-Bing Guan, Ming-Song Hsieh, Hung-Cheng Lai, Chien-Jen Chen, Ya-Wen Lin
BACKGROUND: Aberrant DNA methylation is associated with the development of hepatocellular carcinoma (HCC), suggesting that gene methylation could be a potential biomarker for detection of HCC. The aim of this study is to identify potential biomarkers in HCC. METHODS: We used the Infinium methylation array and a DNA-pooling strategy to analyze the genome-wide methylation profile in HCC. Quantitative methylation-specific PCR (Q-MSP) was used to validate homeobox A9 (HOXA9) methylation in 29 normal controls, 100 HCC samples and adjacent non-tumor tissues and in 74 plasma samples, including 40 patients with HCC...
August 2014: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/24513876/exhaustive-exercise-modifies-different-gene-expression-profiles-and-pathways-in-lps-stimulated-and-un-stimulated-whole-blood-cultures
#19
Asghar Abbasi, Melanie Hauth, Michael Walter, Jens Hudemann, Veit Wank, Andreas M Niess, Hinnak Northoff
Exhaustive exercise can interfere with immunity, causing transient immunosuppression and infections/inflammation in athletes. We used microarray technology to analyze the gene expression profiles of whole blood in short time (1h) LPS-stimulated and un-stimulated cultures drawn before, 30min after, 3h after and 24h after a half-marathon run. Four male and 4 female athletes participated. Exercise induced differential expression of genes known to be involved in innate immunity/inflammatory response, metabolic response, DNA methylation, apoptosis and regulation of brain function...
July 2014: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/24138068/age-related-alterations-in-gene-expression-of-gingival-fibroblasts-stimulated-with-porphyromonas-gingivalis
#20
H Domon, K Tabeta, T Nakajima, K Yamazaki
BACKGROUND AND OBJECTIVE: Elderly people exhibit increased susceptibility to a number of autoimmune and infectious diseases, such as periodontitis. Although aging is reportedly associated with a decline in immune function, age-related alterations in periodontal tissue have remained elusive. In the present study, we comprehensively analyzed the effect of aging on the expression of selected genes using mouse gingival fibroblasts. MATERIAL AND METHODS: Gingival fibroblasts derived from young (8 wk of age) and old (≥ 24 mo of age) C57BL/6 mice were stimulated with Porphyromonas gingivalis lipopolysaccharide or live P...
August 2014: Journal of Periodontal Research
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