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https://www.readbyqxmd.com/read/28213252/multi-pumping-flow-system-for-the-determination-of-boron-in-eye-drops-drinking-water-and-ocean-water
#1
Pablo González, Alexandra Sixto, Moisés Knochen
A novel automated method for the determination of boron based on the use of pulsed flows was developed and applied to the determination of this element in samples of tap water, ocean water and eye drops. The method was implemented by means of a multi-pumping system consisting of three solenoid micropumps and a photometric detector and exploits the reaction of azomethine-H in the presence of boron. The system runs under control of an open-source microcontroller. The main operational parameters were optimized...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28199368/secondary-structure-prediction-revisited-theoretical-%C3%AE-sheet-propensity-and-coil-propensity-represent-structures-of-amyloids-and-aid-in-elucidating-phenomena-involved-in-interspecies-transmission-of-prions
#2
Yuzuru Taguchi, Noriyuki Nishida
Prions are unique infectious agents, consisting solely of abnormally-folded prion protein (PrPSc). However, they possess virus-like features, including strain diversity, the ability to adapt to new hosts and to be altered evolutionarily. Because prions lack genetic material (DNA and RNA), these biological phenomena have been attributed to the structural properties of PrPSc. Therefore, many structural models of the structure of PrPSc have been proposed based on the limited structural information available, regardless of the incompatibility with high-resolution structural analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28175935/a-flow-microslot-nmr-probe-coupled-with-a-capillary-isotachophoresis-system-exhibits-improved-properties-compared-to-solenoid-designs
#3
Mikheil Gogiashvili, Ahmad Telfah, Jörg Lambert, Roland Hergenröder
We report on the hyphenation of capillary isotachophoresis (cITP) separations with online nuclear magnetic resonance (NMR) detection using a planar microslot waveguide probe design. While cITP is commonly coupled with a solenoidal microcoil NMR probe, the structural information provided is limited by broad resonances and poor spectral resolution due to the magnetic field created by the separation current. The microslot probe design described herein allows the separation capillary to be oriented parallel to the static magnetic field, B 0, eliminating the spectral broadening produced by the secondary magnetic field induced by the separation current...
February 7, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28134131/design-and-characterization-of-a-cough-simulator
#4
Bo Zhang, Chao Zhu, Zhiming Ji, Chao-Hsin Lin
Expiratory droplets from human coughing have always been considered as potential carriers of pathogens, responsible for respiratory infectious disease transmission. To study the transmission of disease by human coughing, a transient repeatable cough simulator has been designed and built. Cough droplets are generated by different mechanisms, such as the breaking of mucus, condensation and high-speed atomization from different depths of the respiratory tract. These mechanisms in coughing produce droplets of different sizes, represented by a bimodal distribution of "fine" and "coarse" droplets...
January 30, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28113861/in-vivo-magnetic-stimulation-of-rat-sciatic-nerve-with-centimeter-and-millimeter-scale-solenoid-coils
#5
Zachary Kagan, Anil RamRakhyani, Gianluca Lazzi, Richard Normann, David Warren
Previous reports of magnetic stimulation of the peripheral nervous system (PNS) used various coil geometries, all with outer diameters larger than 35 mm, and stimulation energies in the 50 J range to evoke neural excitation. Recent reports of central nervous system (CNS) activation used sub-mm-scale solenoid coils with mJ energy levels. The goal of this study was to translate the lower energy levels from the CNS to the PNS via using smaller coils placed in closer proximity to the neural tissue. Such a performance improvement would advance the state of the art of magnetic stimulation and provide a path towards new neuroprosthetic devices...
March 21, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28112223/development-of-a-facile-droplet-based-single-cell-isolation-platform-for-cultivation-and-genomic-analysis-in-microorganisms
#6
Qiang Zhang, Tingting Wang, Qian Zhou, Peng Zhang, Yanhai Gong, Honglei Gou, Jian Xu, Bo Ma
Wider application of single-cell analysis has been limited by the lack of an easy-to-use and low-cost strategy for single-cell isolation that can be directly coupled to single-cell sequencing and single-cell cultivation, especially for small-size microbes. Herein, a facile droplet microfluidic platform was developed to dispense individual microbial cells into conventional standard containers for downstream analysis. Functional parts for cell encapsulation, droplet inspection and sorting, as well as a chip-to-tube capillary interface were integrated on one single chip with simple architecture, and control of the droplet sorting was achieved by a low-cost solenoid microvalve...
January 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28109330/the-structure-of-mammalian-prions-and-their-aggregates
#7
E Vázquez-Fernández, H S Young, J R Requena, H Wille
Prion diseases, such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy in cattle, chronic wasting disease in cervids (i.e., deer, elk, moose, and reindeer), and sheep scrapie, are caused by the misfolding of the cellular prion protein (PrP(C)) into a disease-causing conformer (PrP(Sc)). PrP(C) is a normal, GPI-anchored protein that is expressed on the surface of neurons and other cell types. The structure of PrP(C) is well understood, based on studies of recombinant PrP, which closely mimics the structure of native PrP(C)...
2017: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/28107915/a-clean-photometric-method-for-the-determination-of-losartan-potassium-in-pharmaceuticals-exploiting-light-scattering-effect-and-employing-a-multicommuted-flow-analysis-approach
#8
Manoel J A Lima, Boaventura F Reis
This paper describes an environmentally friendly procedure for the determination of losartan potassium (Los-K) in pharmaceuticals. The photometric method was based on the light scattering effect due to particles suspension, which were formed by the reaction of Los-K with Cu (II) ions. The method was automated employing a multicommuted flow analysis approach, implemented using solenoid mini-pumps for fluid propelling and a homemade LED based photometer. Under the optimized experimental conditions, the procedure showed a linear relationship in the concentration range of 23...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28069763/photokinetic-analysis-of-the-forces-and-torques-exerted-by-optical-tweezers-carrying-angular-momentum
#9
Aaron Yevick, Daniel J Evans, David G Grier
The theory of photokinetic effects expresses the forces and torques exerted by a beam of light in terms of experimentally accessible amplitude and phase profiles. We use this formalism to develop an intuitive explanation for the performance of optical tweezers operating in the Rayleigh regime, including effects arising from the influence of light's angular momentum. First-order dipole contributions reveal how a focused beam can trap small objects, and what features limit the trap's stability. The first-order force separates naturally into a conservative intensity-gradient term that forms a trap and a non-conservative solenoidal term that drives the system out of thermodynamic equilibrium...
February 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28047458/mo-ab-bra-08-a-modular-multi-source-x-ray-tube-for-novel-computed-tomography-applications
#10
B Walker, J Radtke, G Petry, R Swader, G Chen, K Eliceiri, T Mackie
PURPOSE: To develop and build a practical implementation of an x-ray line source for the rapidly increasing number of multi-source imaging applications in CT. METHODS: An innovative x-ray tube was designed using CST Particle Studio, ANSYS, and SolidWorks. A slowly varying magnetic field is synchronized with microsecond gating of multiple thermionic electron sources. Electrostatic simulations were run to optimize the geometry of the optics and prevent electrode arcing...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047162/tu-h-bra-08-the-design-and-characteristics-of-a-novel-compact-linac-based-mri-guided-radiation-therapy-mr-igrt-system
#11
S Mutic, D Low, T Chmielewski, G Fought, M Hernandez, I Kawrakow, A Sharma, S Shvartsman, J Dempsey
PURPOSE: To describe the design and characteristics of a novel linac-based MRI guided radiation therapy system that addresses RF and magnetic field interference and that can be housed in conventional radiotherapy vaults. METHODS: The MR-IGRT system will provide simultaneous MR imaging combined with both simple (3D) and complex (IMRT, SBRT, SRS) techniques. The system is a combination of a) double-donut split solenoidal superconducting 0.345T MRI; and b) a 90 cm isocenter ring-gantry mounted 6MV, flattening filter-free linac coupled with a stacked doubly-focused multileaf collimator with 4 mm resolution...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28040941/neutron-resonance-spin-echo-with-longitudinal-dc-fields
#12
Maximilian Krautloher, Jonas Kindervater, Thomas Keller, Wolfgang Häußler
We report on the design, construction, and performance of a neutron resonance spin echo (NRSE) instrument employing radio frequency (RF) spin flippers combining RF fields with DC fields, the latter oriented parallel (longitudinal) to the neutron propagation direction (longitudinal NRSE (LNRSE)). The advantage of the longitudinal configuration is the inherent homogeneity of the effective magnetic path integrals. In the center of the RF coils, the sign of the spin precession phase is inverted by a π flip of the neutron spins, such that non-uniform spin precession at the boundaries of the RF flippers is canceled...
December 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28026051/the-effects-of-electromagnetic-fields-on-b16-bl6-cells-are-dependent-on-their-spatial-and-temporal-character
#13
Carly A Buckner, Alison L Buckner, Stan A Koren, Michael A Persinger, Robert M Lafrenie
Exposure to low intensity, low frequency electromagnetic fields (EMF) has effects on several biological systems. Spatiotemporal characteristics of these EMFs are critical. The effect of several complex EMF patterns on the proliferation of B16-BL6 mouse melanoma cells was tested. Exposure to one of these patterns, the Thomas-EMF, inhibited cell proliferation and promoted calcium uptake. The Thomas-EMF is coded from a digital-to-analog file comprised of 849 points, which provides power to solenoids and can be set to alter timing, intensity, and duration of variable EMF...
December 27, 2016: Bioelectromagnetics
https://www.readbyqxmd.com/read/28024297/variable-chromatin-structure-revealed-by-in-situ-spatially-correlated-dna-cleavage-mapping
#14
Viviana I Risca, Sarah K Denny, Aaron F Straight, William J Greenleaf
Chromatin structure at the length scale encompassing local nucleosome-nucleosome interactions is thought to play a crucial role in regulating transcription and access to DNA. However, this secondary structure of chromatin remains poorly understood compared with the primary structure of single nucleosomes or the tertiary structure of long-range looping interactions. Here we report the first genome-wide map of chromatin conformation in human cells at the 1-3 nucleosome (50-500 bp) scale, obtained using ionizing radiation-induced spatially correlated cleavage of DNA with sequencing (RICC-seq) to identify DNA-DNA contacts that are spatially proximal...
December 26, 2016: Nature
https://www.readbyqxmd.com/read/27995029/thermal-hydraulic-analysis-of-the-coil-test-facility-for-cfetr
#15
Yong Ren, Xiaogang Liu, Junjun Li, Zhaoliang Wang, Lilong Qiu, Shijun Du, Guoqiang Li, Xiang Gao
BACKGROUND: Performance test of the China Fusion Engineering Test Reactor (CFETR) central solenoid (CS) and toroidal field (TF) insert coils is of great importance to evaluate the CFETR magnet performance in relevant operation conditions. The superconducting magnet of the coil test facility for CFETR is being designed with the aim of providing a background magnetic field to test the CFETR CS insert and TF insert coils. RESULTS: The superconducting magnet consists of the inner module with Nb3Sn coil and the outer module with NbTi coil...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27941986/numerical-investigation-of-oxygenated-and-deoxygenated-blood-flow-through-a-tapered-stenosed-arteries-in-magnetic-field
#16
M Y Abdollahzadeh Jamalabadi, Amin Ali Akbari Bidokhti, Hamid Khak Rah, Siavash Vaezi, Payam Hooshmand
Current paper is focused on transient modeling of blood flow through a tapered stenosed arteries surrounded a by solenoid under the presence of heat transfer. The oxygenated and deoxygenated blood are considered here by the Newtonian and Non-Newtonian fluid (power law and Carreau-Yasuda) models. The governing equations of bio magnetic fluid flow for an incompressible, laminar, homogeneous, non-Newtonian are solved by finite volume method with SIMPLE algorithm for structured grid. Both magnetization and electric current source terms are well thought-out in momentum and energy equations...
2016: PloS One
https://www.readbyqxmd.com/read/27910537/highly-sensitive-superconducting-circuits-at-%C3%A2-700-khz-with-tunable-quality-factors-for-image-current-detection-of-single-trapped-antiprotons
#17
H Nagahama, G Schneider, A Mooser, C Smorra, S Sellner, J Harrington, T Higuchi, M Borchert, T Tanaka, M Besirli, K Blaum, Y Matsuda, C Ospelkaus, W Quint, J Walz, Y Yamazaki, S Ulmer
We developed highly sensitive image-current detection systems based on superconducting toroidal coils and ultra-low noise amplifiers for non-destructive measurements of the axial frequencies (550-800 kHz) of single antiprotons stored in a cryogenic multi-Penning-trap system. The unloaded superconducting tuned circuits show quality factors of up to 500 000, which corresponds to a factor of 10 improvement compared to our previously used solenoidal designs. Connected to ultra-low noise amplifiers and the trap system, signal-to-noise-ratios of 30 dB at quality factors of >20 000 are achieved...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910375/high-precision-measurement-of-magnetic-penetration-depth-in-superconducting-films
#18
X He, A Gozar, R Sundling, I Božović
The magnetic penetration depth (λ) in thin superconducting films is usually measured by the mutual inductance technique. The accuracy of this method has been limited by uncertainties in the geometry of the solenoids and in the film position and thickness, by parasitic coupling between the coils, etc. Here, we present several improvements in the apparatus and the method. To ensure the precise thickness of the superconducting layer, we engineer the films at atomic level using atomic-layer-by-layer molecular beam epitaxy...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27858026/a-portable-microfluidic-system-for-rapid-measurement-of-the-erythrocyte-sedimentation-rate
#19
Ziya Isiksacan, Ozcan Erel, Caglar Elbuken
The erythrocyte sedimentation rate (ESR) is a frequently used 30 min or 60 min clinical test for screening of several inflammatory conditions, infections, trauma, and malignant diseases, as well as non-inflammatory conditions including prostate cancer and stroke. Erythrocyte aggregation (EA) is a physiological process where erythrocytes form face-to-face linear structures, called rouleaux, at stasis or low shear rates. In this work, we proposed a method for ESR measurement from EA. We developed a microfluidic opto-electro-mechanical system, using which we experimentally showed a significant correlation (R(2) = 0...
November 18, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27856162/generation-of-digitized-microfluidic-filling-flow-by-vent-control
#20
Junghyo Yoon, Eundoo Lee, Jaehoon Kim, Sewoon Han, Seok Chung
Quantitative microfluidic point-of-care testing has been translated into clinical applications to support a prompt decision on patient treatment. A nanointerstice-driven filling technique has been developed to realize the fast and robust filling of microfluidic channels with liquid samples, but it has failed to provide a consistent filling time owing to the wide variation in liquid viscosity, resulting in an increase in quantification errors. There is a strong demand for simple and quick flow control to ensure accurate quantification, without a serious increase in system complexity...
October 28, 2016: Biosensors & Bioelectronics
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