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https://www.readbyqxmd.com/read/28822891/comparative-toxicity-of-the-plasticizer-dibutyl-phthalate-to-two-freshwater-algae
#1
Shurui Gu, Hao Zheng, Qingqing Xu, Cuizhu Sun, Mei Shi, Zhenyu Wang, Fengmin Li
Phthalate esters (PAEs), a family of emerging environmental contaminants, have been frequently detected in soils and water. However, intensive studies on the toxicity of PAEs have focused on growth response of terrestrial and aquatic animals, while only limited attention has been paid to aquatic plants, especially phytoplankton, the primary producer in aquatic ecosystems. Therefore, the acute toxic effects and underlying mechanisms of dibutyl phthalate (DBP) at different concentrations (0-20mgL(-1)) on two typical freshwater algae (Scenedesmus obliquus and Chlorella pyrenoidosa) were investigated...
August 12, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28821401/chemical-composition-of-mentha-pulegium-and-rosmarinus-officinalis-essential-oils-and-their-antileishmanial-antibacterial-and-antioxidant-activities
#2
Abdelhakim Bouyahya, Abdeslam Et-Touys, Youssef Bakri, Talbaoui Ahmed, Hajiba Fellah, Jamal Abrini, Nadia Dakka
The aim of the study was the determination of the chemical composition of Mentha pulegium L. and Rosmarinus officinalis L. essential oils and the evaluation of their antileishmanial, antibacterial and antioxidant activities. Essential oils (EOs) were isolated using steam distillation and the chemical composition was determined using GC-MS analysis. The antibacterial activity was tested against ten pathogenic strains using the diffusion method, the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) by microtitration assay...
August 15, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28820990/relative-importance-of-humic-and-fulvic-acid-on-ros-generation-dissolution-and-toxicity-of-sulfide-nanoparticles
#3
Enxiang Shang, Yang Li, Junfeng Niu, Yijing Zhou, Tianyu Wang, John Charles Crittenden
In this study, the effect of natural organic matter (NOM) composition (humic acid (HA) or fulvic acid (FA)) on dissolution, reactive oxygen species (ROS) generation, and toxicity of sulfide nanoparticles (NPs) was investigated under UV irradiation. NOM acted as a UV filter or antioxidant, decreasing ROS (O2(-), OH, and (1)O2) generation by WS2 and MoS2 NPs. The higher light-absorbing fractions of HA in NP/HA mixtures and the faster reaction rate of HA with ROS resulted in higher inhibition effect of HA than FA on O2(-) and OH generation by WS2 and MoS2 NPs...
August 3, 2017: Water Research
https://www.readbyqxmd.com/read/28820966/reactive-oxygen-species-responsive-polymeric-nanoparticles-for-alleviating-sepsis-induced-acute-liver-injury-in-mice
#4
Gan Chen, Hongzhang Deng, Xiang Song, Mingzi Lu, Lian Zhao, Sha Xia, Guoxing You, Jingxiang Zhao, Yulong Zhang, Anjie Dong, Hong Zhou
Sepsis-associated acute liver injury contributes to the pathogenesis of multiple organ dysfunction syndrome and is associated with increased mortality. Currently, no specific therapeutics for sepsis-associated liver injury are available. With excess levels of reactive oxygen species (ROS) being implicated as key players in sepsis-induced liver injury, we hypothesize that ROS-responsive nanoparticles (NPs) formed via the self-assembly of diblock copolymers of poly(ethylene glycol) (PEG) and poly(propylene sulfide) (PPS) may function as an effective drug delivery system for alleviating sepsis-induced liver injury by preferentially releasing drug molecules at the disease site...
August 11, 2017: Biomaterials
https://www.readbyqxmd.com/read/28820904/parametric-studies-of-metabolic-cooperativity-in-escherichia-coli-colonies-strain-and-geometric-confinement-effects
#5
Joseph R Peterson, John A Cole, Zaida Luthey-Schulten
Characterizing the complex spatial and temporal interactions among cells in a biological system (i.e. bacterial colony, microbiome, tissue, etc.) remains a challenge. Metabolic cooperativity in these systems can arise due to the subtle interplay between microenvironmental conditions and the cells' regulatory machinery, often involving cascades of intra- and extracellular signalling molecules. In the simplest of cases, as demonstrated in a recent study of the model organism Escherichia coli, metabolic cross-feeding can arise in monoclonal colonies of bacteria driven merely by spatial heterogeneity in the availability of growth substrates; namely, acetate, glucose and oxygen...
2017: PloS One
https://www.readbyqxmd.com/read/28820741/electromagnetic-and-optical-characteristics-of-nb5-doped-double-crossover-and-salmon-dna-thin-films
#6
Mitta Sekhar Babu, Sreekantha Reddy Dugasani, Soon-Gil Jung, Srivithya Vellampatti, Tuson Park, Sung Ha Park
We report the fabrication and physical characteristics of niobium ion (Nb5+)-doped double-crossover DNA (DX-DNA) and salmon DNA (SDNA) thin films. Different concentrations of Nb5+ ([Nb5+]) are coordinated into the DNA molecules, and the thin films are fabricated via substrate-assisted growth (DX-DNA) and drop-casting (SDNA) on oxygen plasma treated substrates. We conducted atomic force microscopy to estimate the optimum concentration of Nb5+ ([Nb5+]O = 0.08 mM) in Nb5+-doped DX-DNA thin films, up to which the DX-DNA lattices maintain their structures without deformation...
August 18, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28820028/extracorporeal-membrane-oxygenation-for-acute-respiratory-distress-syndrome-in-adults-an-analysis-of-differences-between-survivors-and-non-survivors
#7
Bernd Panholzer, Katrin Meckelburg, Katharina Huenges, Grischa Hoffmann, Michael von der Brelie, Nils Haake, Kevin Pilarczyk, Jochen Cremer, Assad Haneya
OBJECTIVES: Over the last decade, extracorporeal membrane oxygenation (ECMO) has become a promising option for patients with severe acute respiratory distress syndrome (ARDS). In this single-center observational cohort study, data from a patient group with severe ARDS treated with ECMO was analyzed. METHODS: Data from 46 patients [median age 54 years (18 to 72), male: 65.2%] were evaluated retrospectively between January 2009 and September 2015. RESULTS: Diagnosis leading to ARDS was pneumonia in 63...
September 2017: Perfusion
https://www.readbyqxmd.com/read/28819754/development-of-the-hybrid-cells-in-series-model-to-simulate-ammonia-nutrient-pollutant-transport-along-the-umgeni-river
#8
Kayode O Olowe, Muthukrishnavellaisamy Kumarasamy
Discharge of organic waste results in high nutrient pollution of the water bodies which is a major menace to the environment. A high quantity of nutrients such as ammonia causes a reduction in the dissolved oxygen level and induces algal growth in the water bodies. Water quality models have been the tools to evaluate the rate at which streams can disperse the pollutants they receive. Many water quality models are flawed either because of their inadequacy to completely simulate the advection component of the pollutant transport, or because of the limited application of the models, due to inaccurate estimation of model parameters...
August 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28819708/in-situ-remediation-of-chlorinated-solvent-contaminated-groundwater-using-zvi-organic-carbon-amendment-in-china-field-pilot-test-and-full-scale-application
#9
Jie Yang, Liang Meng, Lin Guo
Chlorinated solvents in groundwater pose threats to human health and the environment due to their carcinogenesis and bioaccumulation. These problems are often more severe in developing countries such as China. Thus, methods for chlorinated solvent-contaminated groundwater remediation are urgently needed. This study presents a technique of in situ remediation via the direct-push amendment injection that enhances the reductive dechlorination of chlorinated solvents in groundwater in the low-permeability aquifer...
August 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28819394/a-role-for-the-atp7a-copper-transporter-in-tumorigenesis-and-cisplatin-resistance
#10
Sha Zhu, Vinit Shanbhag, Yanfang Wang, Jaekwon Lee, Michael Petris
The ATP7A protein is a ubiquitously expressed copper-translocating P-type ATPase that controls cytoplasmic copper concentrations by mediating cellular copper egress. In vitro studies have previously demonstrated that ATP7A abundance in various tumor cell lines is correlated with increased resistance to cisplatin, a widely-used chemotherapy agent. However, to date no studies have examined a role for ATP7A in tumor growth or cisplatin sensitivity in vivo. In this study, we deleted ATP7A in H-RAS transformed tumorigenic mouse embryonic fibroblasts (MEF(RAS)7A-)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28819370/metformin-inhibits-gemcitabine-induced-apoptosis-in-pancreatic-cancer-cell-lines
#11
Dietmar Zechner, Ann-Christin Albert, Florian Bürtin, Brigitte Vollmar
Many preclinical and clinical studies are currently evaluating metformin in combination with classical therapeutic agents as anti-cancer therapy. In this study we used three distinct pancreatic cancer cell lines and evaluated cell death by trypan blue assay and Western Blots using antibodies directed against cleaved caspase 3 and PARP. Surprisingly, we observed that 20mM metformin did not enhance, but rather inhibited gemcitabine induced cell death in murine 7265PDA, 6606PDA and 6606l cells. Microenvironmental aspects such as oxygen supply or the pH value did not influence the inhibition of cancer cell apoptosis by metformin...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28819291/a-single-molecule-assessment-of-the-protective-effect-of-dmso-against-dna-double-strand-breaks-induced-by-photo-and-%C3%AE-ray-irradiation-and-freezing
#12
Masami Noda, Yue Ma, Yuko Yoshikawa, Tadayuki Imanaka, Toshiaki Mori, Masakazu Furuta, Tatsuaki Tsuruyama, Kenichi Yoshikawa
Dimethyl sulfoxide (DMSO) is widely used as a cryoprotectant for organs, tissues, and cell suspension in storage. In addition, DMSO is known to be a useful free radical scavenger and a radio-protectant. To date, many in vitro assays using cultured cells have been performed for analysing the protective effect of DMSO against genomic DNA damage; however, currently it has been rather difficult to detect DNA double strand breaks (DSBs) in a quantitative manner. In the present study, we aimed to observe the extent of DNA damage by use of single molecular observation with a fluorescence microscope to evaluate DSBs induced by photo- and γ-ray-irradiation, or freeze/thawing in variable concentrations of DMSO...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819268/heterogenous-oceanic-redox-conditions-through-the-ediacaran-cambrian-boundary-limited-the-metazoan-zonation
#13
Junpeng Zhang, Tailiang Fan, Yuandong Zhang, Gary G Lash, Yifan Li, Yue Wu
Recent studies have enhanced our understanding of the linkage of oxygenation and metazoan evolution in Early Cambrian time. However, little of this work has addressed the apparent lag of animal diversification and atmospheric oxygenation during this critical period of Earth history. This study utilizes the geochemical proxy and N isotope record of the Ediacaran-Cambrian boundary preserved in intra-shelf basin, slope, and slope basin deposits of the Yangtze Sea to assess the ocean redox state during the Early Cambrian metazoan radiation...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818871/sexual-dimorphism-of-the-pulmonary-transcriptome-in-neonatal-hyperoxic-lung-injury-identification-of-angiogenesis-as-a-key-pathway
#14
Cristian Coarfa, Yuhao Zhang, Suman Maity, Dimuthu Perera, Weiwu Jiang, Lihua Wang, Xanthi Couroucli, Bhagavatula Moorthy, Krithika Lingappan
Bronchopulmonary dysplasia (BPD) is characterized by impaired alveolar secondary septation and vascular growth. Exposure to high concentrations of oxygen (hyperoxia) contributes to the development of BPD. Male sex is considered an independent risk factor for the development of BPD. The reasons underlying sexually dimorphic outcomes in premature neonates are not known. We hypothesized that sex-specific modulation of biological processes in the lung under hyperoxic conditions, contributes to sex-based differences...
August 17, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28818519/decomposition-characteristics-of-three-different-kinds-of-aquatic-macrophytes-and-their-potential-application-as-carbon-resource-in-constructed-wetland
#15
Suqing Wu, Shengbing He, Weili Zhou, Jianya Gu, Jungchen Huang, Lei Gao, Xu Zhang
Decomposition of aquatic macrophytes usually generates significant influence on aquatic environment. Study on the aquatic macrophytes decomposition may help reusing the aquatic macrophytes litters, as well as controlling the water pollution caused by the decomposition process. This study verified that the decomposition processes of three different kinds of aquatic macrophytes (water hyacinth, hydrilla and cattail) could exert significant influences on water quality of the receiving water, including the change extent of pH, dissolved oxygen (DO), the contents of carbon, nitrogen and phosphorus, etc...
August 14, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28818407/effects-of-copper-oxide-nanoparticles-and-copper-ions-to-zebrafish-danio-rerio-cells-embryos-and-fry
#16
Amalie Thit, Lars M Skjolding, Henriette Selck, Joachim Sturve
The use of engineered metal nanoparticles (NPs) is continuously increasing and so is the need for information regarding their toxicity. This study compares the toxicity of CuO NPs with ionic Cu in three zebrafish model systems; zebrafish hepatoma cell line (ZFL), fish embryo toxicity test (FET) and fry locomotion. In the ZFL tests, no significant cytotoxicity (cell death, decreased metabolic or cell membrane integrity) was detected for either treatment, though both significantly affected reactive oxygen species (ROS) production...
August 14, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28817659/resveratrol-improves-alcoholic-fatty-liver-disease-by-downregulating-hif-1%C3%AE-expression-and-mitochondrial-ros-production
#17
Zhenhua Ma, Yangmin Zhang, Qingchun Li, Meng Xu, Jigang Bai, Shengli Wu
Oxidative stress has been demonstrated to be involved in the etiology of alcoholic fatty liver disease (AFLD). Previous studies had demonstrated that resveratrol (RES) could reduce oxidative stress by different mechanisms. However, the effect of RES on alcohol-induced fatty liver remains unclear. In the present study, a total of 48 male SD rats were divided into three groups: Control, AFLD, and RES groups. Rats were administered with either nothing or 65% vol/vol alcohol (5 ml/kg/day in the first three days, and then 10 ml/kg/day in the following days) with or without RES supplementation (250 mg/kg/day) for 4 weeks...
2017: PloS One
https://www.readbyqxmd.com/read/28816922/nil-whey-protein-effect-on-glycaemic-control-after-intense-mixed-mode-training-in-t2d
#18
Kim A Gaffney, Adam Lucero, Lee Stoner, James Faulkner, Patricia Whitfield, Jeremy Krebs, David S Rowlands
While intense endurance and resistance exercise training and whey protein supplementation have both been shown to independently improve glycaemic control, no known studies have examined the effect of high-intensity mixed-mode interval training (MMIT) and whey supplementation in adults with Type-2 diabetes (T2D). PURPOSE: To determine if peri-training whey protein supplementation combined with MMIT can improve glycaemic control. METHODS: In a double-blind randomised controlled trial, 24 men (55...
August 14, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28816645/a-systems-model-of-parkinson-s-disease-using-biochemical-systems-theory
#19
Hemalatha Sasidharakurup, Nidheesh Melethadathil, Bipin Nair, Shyam Diwakar
Parkinson's disease (PD), a neurodegenerative disorder, affects millions of people and has gained attention because of its clinical roles affecting behaviors related to motor and nonmotor symptoms. Although studies on PD from various aspects are becoming popular, few rely on predictive systems modeling approaches. Using Biochemical Systems Theory (BST), this article attempts to model and characterize dopaminergic cell death and understand pathophysiology of progression of PD. PD pathways were modeled using stochastic differential equations incorporating law of mass action, and initial concentrations for the modeled proteins were obtained from literature...
August 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28816359/chrysin-attenuates-progression-of-ovarian-cancer-cells-by-regulating-signaling-cascades-and-mitochondrial-dysfunction
#20
Whasun Lim, Soomin Ryu, Fuller W Bazer, Sung-Man Kim, Gwonhwa Song
Chrysin is mainly found in passion flowers, honey, and propolis acts as a potential therapeutic and preventive agent to inhibit proliferation and invasion of various human cancer cells. Although chrysin has anti-carcinogenic effects in several cancers, little is known about its functional roles in ovarian cancer which shows poor prognosis and chemoresistance to traditional therapeutic agents. In the present study, we investigated functional roles of chrysin in progression of ovarian cancer cells using ES2 and OV90 (clear cell and serous carcinoma, respectively) cell lines...
August 17, 2017: Journal of Cellular Physiology
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