Anne-Sophie Cloos, Hélène Pollet, Amaury Stommen, Mauriane Maja, Maxime Lingurski, Benedicte Brichard, Catherine Lambert, Patrick Henriet, Christophe Pierreux, Sébastien Pyr Dit Ruys, Patrick Van Der Smissen, Miikka Vikkula, Laurent Gatto, Manon Martin, Pascal Brouillard, Didier Vertommen, Donatienne Tyteca
Splenectomy improves clinical parameters of patients with hereditary spherocytosis but its potential benefit to red blood cell (RBC) functionality and the mechanism behind this benefit remain largely overlooked. We here compared 7 non-splenectomized and 12 splenectomized patients with mutations in the β-spectrin (SPTB) or the ankyrin (ANK1) gene. We showed that hematological parameters, spherocyte abundance, osmotic fragility, intracellular calcium and extracellular vesicle release were largely but not completely restored by splenectomy whereas cryohemolysis was not...
February 8, 2023: Blood Advances