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salience network, DTI

Conrad Prillwitz, Theodor RĂ¼ber, Martin Reuter, Christian Montag, Bernd Weber, Christian E Elger, Sebastian Markett
A prevailing topic in personality neuroscience is the question how personality traits are reflected in the brain. Functional and structural networks have been examined by functional and structural magnetic resonance imaging, however, the structural correlates of functionally defined networks have not been investigated in a personality context. By using the Temperament and Character Inventory (TCI) and Diffusion Tensor Imaging (DTI), the present study assesses in a sample of 116 healthy participants how personality traits proposed in the framework of the biopsychosocial theory on personality relate to white matter pathways delineated by functional network imaging...
April 28, 2018: Brain Research
Feng-Mei Lu, Jing Dai, Tania A Couto, Chun-Hong Liu, Heng Chen, Shun-Li Lu, Li-Rong Tang, Chang-Le Tie, Hua-Fu Chen, Man-Xi He, Yu-Tao Xiang, Zhen Yuan
Neuroimaging studies have revealed that insomnia is characterized by aberrant neuronal connectivity in specific brain regions, but the topological disruptions in the white matter (WM) structural connectivity networks remain largely unknown in insomnia. The current study uses diffusion tensor imaging (DTI) tractography to construct the WM structural networks and graph theory analysis to detect alterations of the brain structural networks. The study participants comprised 30 healthy subjects with insomnia symptoms (IS) and 62 healthy subjects without IS...
2017: Frontiers in Human Neuroscience
S Jiang, C Luo, J Gong, R Peng, S Ma, S Tan, G Ye, L Dong, D Yao
The purpose of this study was to investigate the functional connectivity (FC) of thalamic subdivisions in patients with juvenile myoclonic epilepsy (JME). Resting state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) data were acquired from 22 JME and 25 healthy controls. We first divided the thalamus into eight subdivisions by performing independent component analysis on tracking fibers and clustering thalamus-related FC maps. We then analyzed abnormal FC in each subdivision in JME compared with healthy controls, and we investigated their associations with clinical features...
February 2018: International Journal of Neural Systems
Mina M Rizk, Harry Rubin-Falcone, John Keilp, Jeffrey M Miller, M Elizabeth Sublette, Ainsley Burke, Maria A Oquendo, Ahmed M Kamal, Mohamed A Abdelhameed, J John Mann
BACKGROUND: Major depressive disorder (MDD) is associated with impaired attention control and alterations in frontal-subcortical connectivity. We hypothesized that attention control as assessed by Stroop task interference depends on white matter integrity in fronto-cingulate regions and assessed this relationship using diffusion tensor imaging (DTI) in MDD and healthy volunteers (HV). METHODS: DTI images and Stroop task were acquired in 29 unmedicated MDD patients and 16 HVs, aged 18-65 years...
November 2017: Journal of Affective Disorders
Maria C Padula, Marie Schaer, Elisa Scariati, Johanna Maeder, Maude Schneider, Stephan Eliez
Large-scale brain networks play a prominent role in cognitive abilities and their activity is impaired in psychiatric disorders, such as schizophrenia. Patients with 22q11.2 deletion syndrome (22q11DS) are at high risk of developing schizophrenia and present similar cognitive impairments, including executive functions deficits. Thus, 22q11DS represents a model for the study of neural biomarkers associated with schizophrenia. In this study, we investigated structural and functional connectivity within and between the Default Mode (DMN), the Central Executive (CEN), and the Saliency network (SN) in 22q11DS using resting-state fMRI and DTI...
April 2017: Human Brain Mapping
Yangding Li, Kai Yuan, Yanyan Guan, Jiadong Cheng, Yanzhi Bi, Sha Shi, Ting Xue, Xiaoqi Lu, Wei Qin, Dahua Yu, Jie Tian
Studying the neural correlates of smoking behaviors in young adulthood is of great importance to improve treatment outcomes. In previous addiction studies, the important roles of the salience network (SN) in drug cue processing and cognitive control have been revealed. Unfortunately, few studies focused on the resting-state functional connectivity and structural integrity abnormalities of SN in young adult smokers, and less is known about its association with smoking behaviors and cognitive control deficits...
August 2017: Brain Imaging and Behavior
Quan Chen, Xingui Chen, Xiaoxuan He, Lu Wang, Kai Wang, Bensheng Qiu
Consistent structural and functional abnormities have been detected in the salience network (SN) and the central-executive network (CEN) in schizophrenia. SN, known for its critical role in switching CEN and default-mode network (DMN) during cognitively demanding tasks, is proved to show aberrant regulation on the interaction between DMN and CEN in schizophrenia. However, it has not been elucidated whether there is a direct alteration of structural and functional connectivity between SN and CEN. 22 schizophrenia patients and 21 healthy controls were recruited for functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) in present study...
August 3, 2016: Neuroscience Letters
Kun Bi, Lingling Hua, Maobin Wei, Jiaolong Qin, Qing Lu, Zhijian Yao
BACKGROUND: Dynamic functional-structural connectivity (FC-SC) coupling might reflect the flexibility by which SC relates to functional connectivity (FC). However, during the dynamic acute state change phases of FC, the relationship between FC and SC may be distinctive and embody the abnormality inherent in depression. This study investigated the depression-related inter-network FC-SC coupling within particular dynamic acute state change phases of FC. METHODS: Magnetoencephalography (MEG) and diffusion tensor imaging (DTI) data were collected from 26 depressive patients (13 women) and 26 age-matched controls (13 women)...
February 2016: Journal of Affective Disorders
Teresa D Figley, Navdeep Bhullar, Susan M Courtney, Chase R Figley
Diffusion tensor imaging (DTI) is a powerful MRI technique that can be used to estimate both the microstructural integrity and the trajectories of white matter pathways throughout the central nervous system. This fiber tracking (aka, "tractography") approach is often carried out using anatomically-defined seed points to identify white matter tracts that pass through one or more structures, but can also be performed using functionally-defined regions of interest (ROIs) that have been determined using functional MRI (fMRI) or other methods...
2015: Frontiers in Human Neuroscience
Toshiyuki Ohtani, Sylvain Bouix, Amanda E Lyall, Taiga Hosokawa, Yukiko Saito, Eric Melonakos, Carl-Fredrik Westin, Larry J Seidman, Jill Goldstein, Raquelle Mesholam-Gately, Tracey Petryshen, Joanne Wojcik, Marek Kubicki
INTRODUCTION: The medial orbitofrontal cortex (mOFC) and rostral part of anterior cingulate cortex (rACC) have been suggested to be involved in the neural network of salience and emotional processing, and associated with specific clinical symptoms in schizophrenia. Considering the schizophrenia dysconnectivity hypothesis, the connectivity abnormalities between mOFC and rACC might be associated with clinical characteristics in first episode schizophrenia patients (FESZ). METHODS: After parcellating mOFC into the anterior and posterior part, diffusion properties of the mOFC-rACC white matter connections for 21 patients with FESZ and 21 healthy controls (HCs) were examined using stochastic tractography, one of the most effective Diffusion Tensor Imaging (DTI) methods for examining tracts between adjacent gray matter (GM) regions...
October 2015: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Du Lei, Lingjiang Li, Lei Li, Xueling Suo, Xiaoqi Huang, Su Lui, Jing Li, Feng Bi, Graham J Kemp, Qiyong Gong
Posttraumatic stress disorder (PTSD) is a severe anxiety disorder characterized by re-experiencing, avoidance and hyperarousal. Brain microstructure abnormalities in PTSD, especially in children, are not yet well characterized. The aim of this study was to use MR diffusion tensor imaging (DTI) to identify brain microstructure alterations in children with PTSD compared to non-PTSD controls who experienced the same time-limited trauma. We studied 27 children with PTSD and 24 age- and gender-matched traumatized controls without PTSD, who all experienced the 2008 Sichuan major earthquake...
2015: Scientific Reports
Arpana Gupta, Emeran A Mayer, Claudia P Sanmiguel, John D Van Horn, Davis Woodworth, Benjamin M Ellingson, Connor Fling, Aubrey Love, Kirsten Tillisch, Jennifer S Labus
BACKGROUND: Alterations in the hedonic component of ingestive behaviors have been implicated as a possible risk factor in the pathophysiology of overweight and obese individuals. Neuroimaging evidence from individuals with increasing body mass index suggests structural, functional, and neurochemical alterations in the extended reward network and associated networks. AIM: To apply a multivariate pattern analysis to distinguish normal weight and overweight subjects based on gray and white-matter measurements...
2015: NeuroImage: Clinical
Ying Liang, Yaojing Chen, He Li, Tengda Zhao, Xuan Sun, Ni Shu, Dantao Peng, Zhanjun Zhang
Previous studies have demonstrated that Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) exhibited anatomical and functional abnormalities in the anterior cingulate cortex (ACC) and accumulating evidence supported the hypothesis that changes in the ACC predict the progression from aMCI to AD. In this study, we aimed to explore how the two functional and structural heterogeneous sub-regions of ACC, namely the dorsal ACC (dACC) and the ventral ACC (vACC), changed in aMCI and whether the structural connectivity affects the functional connectivity between the two ACC subregions...
2015: Current Alzheimer Research
Lihong Xing, Kai Yuan, Yanzhi Bi, Junsen Yin, Chenxi Cai, Dan Feng, Yangding Li, Min Song, Hongmei Wang, Dahua Yu, Ting Xue, Chenwang Jin, Wei Qin, Jie Tian
The association between the impaired cognitive control and brain regional abnormalities in Internet gaming disorder (IGD) adolescents had been validated in numerous studies. However, few studies focused on the role of the salience network (SN), which regulates dynamic communication among brain core neurocognitive networks to modulate cognitive control. Seventeen IGD adolescents and 17 healthy controls participated in the study. By combining resting-state functional connectivity and diffusion tensor imaging (DTI) tractography methods, we examined the changes of functional and structural connections within SN in IGD adolescents...
October 24, 2014: Brain Research
Peter C Williamson, John M Allman
Some promising genetic correlates of schizophrenia have emerged in recent years but none explain more than a small fraction of cases. The challenge of our time is to characterize the neuronal networks underlying schizophrenia and other neuropsychiatric illnesses. Early models of schizophrenia have been limited by the ability to readily evaluate large-scale networks in living patients. With the development of resting state and advanced structural magnetic resonance imaging, it has become possible to do this...
2012: Frontiers in Human Neuroscience
Kaustubh Supekar, Vinod Menon
Cognitive skills undergo protracted developmental changes resulting in proficiencies that are a hallmark of human cognition. One skill that develops over time is the ability to problem solve, which in turn relies on cognitive control and attention abilities. Here we use a novel multimodal neurocognitive network-based approach combining task-related fMRI, resting-state fMRI and diffusion tensor imaging (DTI) to investigate the maturation of control processes underlying problem solving skills in 7-9 year-old children...
February 2012: PLoS Computational Biology
Jennifer L Whitwell, Ramesh Avula, Ankit Master, Prashanthi Vemuri, Matthew L Senjem, David T Jones, Clifford R Jack, Keith A Josephs
Progressive supranuclear palsy (PSP) is associated with pathological changes along the dentatorubrothalamic tract and in premotor cortex. We aimed to assess whether functional neural connectivity is disrupted along this pathway in PSP, and to determine how functional changes relate to changes in structure and diffusion. Eighteen probable PSP subjects and 18 controls had resting-state (task-free) fMRI, diffusion tensor imaging and structural MRI. Functional connectivity was assessed between thalamus and the rest of the brain, and within the basal ganglia, salience and default mode networks (DMN)...
September 2011: Parkinsonism & related Disorders
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