keyword
MENU ▼
Read by QxMD icon Read
search

cerebellar projections

keyword
https://www.readbyqxmd.com/read/29099739/4sc-202-as-a-potential-treatment-for-the-pediatric-brain-tumor-medulloblastoma
#1
Shanta M Messerli, Mariah M Hoffman, Etienne Z Gnimpieba, Hella Kohlhof, Ratan D Bhardwaj
This project involves an examination of the effect of the small molecule inhibitor 4SC-202 on the growth of the pediatric brain cancer medulloblastoma. The small molecule inhibitor 4SC-202 significantly inhibits the viability of the pediatric desmoplastic cerebellar human medulloblastoma cell line DAOY, with an IC50 = 58.1 nM, but does not affect the viability of noncancerous neural stem cells (NSC). 4SC-202 exposure inhibits hedgehog expression in the DAOY cell line. Furthermore, microarray analysis of human medulloblastoma patient tumors indicate significant upregulation of key targets in the Hedgehog signaling pathway and Protein Tyrosine Kinase (PTK7)...
November 3, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29069799/functional-compatibility-between-purkinje-cell-axon-branches-and-their-target-neurons-in-the-cerebellum
#2
Zhilai Yang, Na Chen, Rongjing Ge, Hao Qian, Jin-Hui Wang
A neuron sprouts an axon, and its branches to innervate many target neurons that are divergent in their functions. In order to efficiently regulate the diversified cells, the axon branches should differentiate functionally to be compatible with their target neurons, i.e., a function compatibility between presynaptic and postsynaptic partners. We have examined this hypothesis by using electrophysiological method in the cerebellum, in which the main axon of Purkinje cell projected to deep nucleus cells and the recurrent axons innervated the adjacent Purkinje cells...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29062268/comparison-of-diffusion-weighted-mri-reconstruction-methods-for-visualization-of-cranial-nerves-in-posterior-fossa-surgery
#3
Brendan Behan, David Q Chen, Francesco Sammartino, Danielle D DeSouza, Erika Wharton-Shukster, Mojgan Hodaie
Diffusion-weighted imaging (DWI)-based tractography has gained increasing popularity as a method for detailed visualization of white matter (WM) tracts. Different imaging techniques, and more novel, advanced imaging methods provide significant WM structural detail. While there has been greater focus on improving tract visualization for larger WM pathways, the relative value of each method for cranial nerve reconstruction and how this methodology can assist surgical decision-making is still understudied. Images from 10 patients with posterior fossa tumors (4 male, mean age: 63...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29061636/synaptic-input-as-a-directional-cue-for-migrating-interneuron-precursors
#4
Annika K Wefers, Christian Haberlandt, Nuriye B Tekin, Dmitry A Fedorov, Aline Timmermann, Johannes J L van der Want, Farrukh A Chaudhry, Christian Steinhäuser, Karl Schilling, Ronald Jabs
During CNS development, interneuron precursors have to migrate extensively before they integrate in specific microcircuits. Known regulators of neuronal motility include classical neurotransmitters, yet the mechanisms that assure interneuron dispersal and interneuron / projection neuron matching during histogenesis remain largely elusive. We combined time-lapse video-microscopy and electrophysiological analysis of the nascent cerebellum of transgenic Pax2-EGFP mice to address this issue. We found that cerebellar interneuronal precursors regularly show spontaneous postsynaptic currents, indicative of synaptic innervation, well before settling in the molecular layer...
October 23, 2017: Development
https://www.readbyqxmd.com/read/29048273/chiari-1000-registry-project-assessment-of-surgical-outcome-on-self-focused-attention-pain-and-delayed-recall
#5
P A Allen, D Delahanty, K P Kaut, X Li, M Garcia, J R Houston, D M Tokar, F Loth, J Maleki, S Vorster, M G Luciano
BACKGROUND: Prior research has typically found a negative relationship between chronic pain and memory, and we examined whether cognitive control processes (e.g. reflection and rumination) moderated this relationship in individuals with Chiari malformation Type I (CM). CM is a neurological condition in which the cerebellar tonsils descend into the medullary and upper cervical spine regions potentially resulting in severe headaches and neck pain. METHODS: CM patients who had (n = 341) and had not (n = 297) undergone decompression surgery completed the McGill Pain Questionnaire-Short Form-Revised (SF-MPQ-2), the Rey Auditory Verbal Learning Test (RAVLT), and the Rumination-Reflection Questionnaire (RRQ)...
October 19, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28979609/examining-microstructural-white-matter-in-active-duty-soldiers-with-a-history-of-mild-traumatic-brain-injury-and-traumatic-stress
#6
Michael N Dretsch, Rael T Lange, Jeffery S Katz, Adam Goodman, Thomas A Daniel, Gopikrishna Deshpande, Thomas S Denney, Grant L Iverson, Jennifer L Robinson
BACKGROUND: There is a high comorbidity of posttraumatic stress (PTS) and mild traumatic brain injury (mTBI), with largely overlapping symptomatology, in military service members. OBJECTIVE: To examine white matter integrity associated with PTS and mTBI as assessed using diffusion tensor imaging (DTI). METHOD: Seventy-four active-duty U.S. soldiers with PTS (n = 16) and PTS with co-morbid history of mTBI (PTS/mTBI; n = 28) were compared to a military control group (n = 30)...
2017: Open Neuroimaging Journal
https://www.readbyqxmd.com/read/28971056/joubert-syndrome-presenting-with-normal-pyramidal-decussation-a-case-report
#7
Nam-Sik Kim, Sung-Hee Park
Joubert syndrome (JS) is a rare genetic disorder characterized by a congenital malformation of the hindbrain, and accompanied by axonal decussation abnormalities affecting the corticospinal tract and the superior cerebellar peduncles. To the best of our knowledge, there are no reports of normal pyramidal decussation in JS. Here, we describe the case of an 18-year-old boy presenting midline-crossing corticospinal projections, which were considered normal corticospinal tract trajectories. Diffusion tensor imaging and motor evoked potential study analysis demonstrated the exclusive presence of decussating corticospinal projections in the patient...
August 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28931264/assessment-of-the-accuracy-and-errors-of-head-up-display-by-an-optical-neuronavigation-system-in-brain-tumor-surgery
#8
Kenichiro Asano, Kosuke Katayama, Kiyohide Kakuta, Kanae Oyama, Hiroki Ohkuma
BACKGROUND: A head-up display (HUD) in which navigational information is projected into the microscope view may enable surgeons to perform operations more efficiently. Projecting depictions of both tumor and important intracranial structures on the HUD may facilitate safe surgery. OBJECTIVE: To investigate accuracy and errors regarding important intracranial structures, errors due to brain shifts, and preservation rates for important intracranial structures. METHODS: A total of 184 surgeries in 172 patients were performed using this operation system...
February 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28904449/james-wenceslaus-papez-his-circuit-and-emotion
#9
Kalyan B Bhattacharyya
James Papez worked on the anatomical substrates of emotion and described a circuit, mainly composed of the hippocampus, thalamus and cingulum, and published his observations in 1937. However, such an idea existed before him, as evidenced by the rudimentary indications from Paul Broca, and Paul MacLean added some other structures like, septum, amygdala, and hypothalamus in its ambit and called it the limbic system. Paul Ivan Yakovlev, proposed a circuit which also referred to orbitofrontal, insular, anterior temporal lobe, and other nuclei of thalamus...
July 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28894610/maturation-refinement-and-serotonergic-modulation-of-cerebellar-cortical-circuits-in-normal-development-and-in-murine-models-of-autism
#10
REVIEW
Eriola Hoxha, Pellegrino Lippiello, Bibiana Scelfo, Filippo Tempia, Mirella Ghirardi, Maria Concetta Miniaci
The formation of the complex cerebellar cortical circuits follows different phases, with initial synaptogenesis and subsequent processes of refinement guided by a variety of mechanisms. The regularity of the cellular and synaptic organization of the cerebellar cortex allowed detailed studies of the structural plasticity mechanisms underlying the formation of new synapses and retraction of redundant ones. For the attainment of the monoinnervation of the Purkinje cell by a single climbing fiber, several signals are involved, including electrical activity, contact signals, homosynaptic and heterosynaptic interaction, calcium transients, postsynaptic receptors, and transduction pathways...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28888908/quick-foot-placement-adjustments-during-gait-are-less-accurate-in-individuals-with-focal-cerebellar-lesions
#11
Wouter Hoogkamer, Zrinka Potocanac, Frank Van Calenbergh, Jacques Duysens
Online gait corrections are frequently used to restore gait stability and prevent falling. They require shorter response times than voluntary movements which suggests that subcortical pathways contribute to the execution of online gait corrections. To evaluate the potential role of the cerebellum in these pathways we tested the hypotheses that online gait corrections would be less accurate in individuals with focal cerebellar damage than in neurologically intact controls and that this difference would be more pronounced for shorter available response times and for short step gait corrections...
October 2017: Gait & Posture
https://www.readbyqxmd.com/read/28862551/isolated-abducens-nerve-palsy-associated-with-subarachnoid-hemorrhage-a-localizing-sign-of-ruptured-posterior-inferior-cerebellar-artery-aneurysms
#12
Jan-Karl Burkhardt, Ethan A Winkler, George F Lasker, John K Yue, Michael T Lawton
OBJECTIVE Compressive cranial nerve syndromes can be useful bedside clues to the diagnosis of an enlarging intracranial aneurysm and can also guide subsequent evaluation, as with an acute oculomotor nerve (cranial nerve [CN] III) palsy that is presumed to be a posterior communicating artery aneurysm and a surgical emergency until proven otherwise. The CN VI has a short cisternal segment from the pontomedullary sulcus to Dorello's canal, remote from most PICA aneurysms but in the hemodynamic pathway of a rupturing PICA aneurysm that projects toward Dorello's canal...
September 1, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28844644/role-of-corticotropin-releasing-factor-in-cerebellar-motor-control-and-ataxia
#13
Yi Wang, Zhang-Peng Chen, Qian-Xing Zhuang, Xiao-Yang Zhang, Hong-Zhao Li, Jian-Jun Wang, Jing-Ning Zhu
Cerebellar ataxia, characterized by motor incoordination, postural instability, and gait abnormality [1-3], greatly affects daily activities and quality of life. Although accumulating genetic and non-genetic etiological factors have been revealed [4-7], effective therapies for cerebellar ataxia are still lacking. Intriguingly, corticotropin-releasing factor (CRF), a peptide hormone and neurotransmitter [8, 9], is considered a putative neurotransmitter in the olivo-cerebellar system [10-14]. Notably, decreased levels of CRF in the inferior olive (IO), the sole origin of cerebellar climbing fibers, have been reported in patients with spinocerebellar degeneration or olivopontocerebellar atrophy [15, 16], yet little is known about the exact role of CRF in cerebellar motor coordination and ataxia...
September 11, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28840087/posterior-inferior-cerebellar-artery-thrombosed-aneurysm-associated-with-persistent-primitive-hypoglossal-artery-successfully-treated-with-condylar-fossa-approach
#14
Norihiro Saito, Rokuya Tanikawa, Toshiyuki Tsuboi, Kosmo Noda, Nakao Ota, Shirou Miyata, Hidetoshi Matsukawa, Takeshi Yanagisawa, Fumihiro Sakakibara, Yu Kinoshita, Takanori Miyazaki, Hiroyasu Kamiyama, Sadahisa Tokuda
A 68-year-old woman presented with generalized seizure due to the left internal carotid artery (ICA) aneurysmal compression of the ipsilateral medial temporal lobe. Computed tomography angiography (CTA) revealed multiple aneurysms of the right persistent primitive hypoglossal artery (PPHA), the right ICA, and the right anterior cerebral artery (ACA). The right PPHA originated from the ICA at the level of the C1 and C2 vertebral bodies and passed through the hypoglossal canal (HC). The PPHA aneurysm was large and thrombosed, which was located at the bifurcation of the right PPHA and the right posterior inferior cerebellar artery (PICA), projecting medially to compress the medulla oblongata...
July 2017: NMC Case Rep J
https://www.readbyqxmd.com/read/28826656/a-morphometric-assessment-of-type-i-chiari-malformation-above-the-mcrae-line-a-retrospective-case-control-study-in-302-adult-female-subjects
#15
James R Houston, Maggie S Eppelheimer, Soroush Heidari Pahlavian, Dipankar Biswas, Aintzane Urbizu, Bryn A Martin, Jayapalli Rajiv Bapuraj, Mark Luciano, Philip A Allen, Francis Loth
PURPOSE: Type I Chiari malformation (CMI) is a radiologically-defined structural dysmorphism of the hindbrain and posterior cranial fossa (PCF). Traditional radiographic identification of CMI relies on the measurement of the cerebellar tonsils in relation to the foramen magnum with or without associated abnormalities of the neuraxis. The primary goal of this retrospective study was to comprehensively assess morphometric parameters above the McRea line in a group of female CMI patients and normal controls...
August 18, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/28821646/location-of-the-mesopontine-neurons-responsible-for-maintenance-of-anesthetic-loss-of-consciousness
#16
Anne Minert, Shai-Lee Yatziv, Marshall Devor
The transition from wakefulness to general anesthesia is widely attributed to suppressive actions of anesthetic molecules distributed by the systemic circulation to the cerebral cortex (for amnesia and loss of consciousness) and to the spinal cord (for atonia and antinociception). An alternative hypothesis proposes that anesthetics act on one or more brainstem or diencephalic nuclei, with suppression of cortex and spinal cord mediated by dedicated axonal pathways. Previously, we documented induction of an anesthesia-like state in rats by microinjection of small amounts of GABAA-receptor agonists into an upper brainstem region named the mesopontine tegmental anesthesia area (MPTA)...
September 20, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28743454/convergence-of-primary-sensory-cortex-and-cerebellar-nuclei-pathways-in-the-whisker-system
#17
REVIEW
Carmen B Schäfer, Freek E Hoebeek
To safely maneuver through the environment the brain needs to compare active sensory information with ongoing motor programs. This process occurs at various levels in the brain: at the lower level, i.e., in the spinal cord, reflexes are generated for the most primitive motor responses; at the intermediate level, i.e., in the brainstem, various nuclei co-process sensory- and motor-related inputs; and, at the higher level cerebellum and thalamo-cortical networks individually compute suitable commands for fine-tuned motor output...
July 22, 2017: Neuroscience
https://www.readbyqxmd.com/read/28720746/-a-rare-case-of-ruptured-internal-carotid-posterior-communicating-artery-aneurysm-associated-with-contralateral-delayed-oculomotor-nerve-palsy
#18
Chika Somagawa, Yutaka Fukuda, Shota Yoshimura, Kei Satoh, Takeshi Hiu, Tomonori Ono, Ryujirou Ushijima, Keisuke Toda, Keisuke Tsutsumi
A 55-year-old man presented with difficulty breathing, chest pain, and disturbance of consciousness, and was transferred to our hospital. Initial whole body CT revealed a diffuse subarachnoid hemorrhage(SAH)with severe pulmonary edema that was considered neurogenic in origin. He received controlled ventilation under sedation and conservative care for the SAH. One day after the onset of the SAH, his left pupil suddenly became dilated to 6mm, with no reaction to light. Head CT showed no new bleeding. Subsequent CT angiogram revealed a right internal carotid-posterior communicating artery aneurysm(IC-PC AN)with a posterior-lateral projection; however, no vessel abnormality was observed in the left anterior or posterior circulations...
July 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28712684/cerebellar-perineuronal-nets-in-cocaine-induced-pavlovian-memory-site-matters
#19
Maria Carbo-Gas, Josep Moreno-Rius, Julian Guarque-Chabrera, Dolores Vazquez-Sanroman, Isis Gil-Miravet, Daniela Carulli, Freek Hoebeek, Chris De Zeeuw, Carla Sanchis-Segura, Marta Miquel
One of the key mechanisms for the stabilization of synaptic changes near the end of critical periods for experience-dependent plasticity is the formation of specific lattice extracellular matrix structures called perineuronal nets (PNNs). The formation of drug memories depends on local circuits in the cerebellum, but it is unclear to what extent it may also relate to changes in their PNN. Here, we investigated changes in the PNNs of the cerebellum following cocaine-induced preference conditioning. The formation of cocaine-related preference memories increased expression of PNN-related proteins surrounding Golgi inhibitory interneurons as well as that of cFos in granule cells at the apex of the cerebellar cortex...
July 14, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28674667/-glial-and-stem-cell-expression-of-murine-fibroblast-growth-factor-receptor-1-in-the-embryonic-and-perinatal-nervous-system
#20
Jantzen C Collette, Lisha Choubey, Karen Müller Smith
BACKGROUND: Fibroblast growth factors (FGFs) and their receptors (FGFRs) are involved in the development and function of multiple organs and organ systems, including the central nervous system (CNS). FGF signaling via FGFR1, one of the three FGFRs expressed in the CNS, stimulates proliferation of stem cells during prenatal and postnatal neurogenesis and participates in regulating cell-type ratios in many developing regions of the brain. Anomalies in FGFR1 signaling have been implicated in certain neuropsychiatric disorders...
2017: PeerJ
keyword
keyword
102420
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"