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https://www.readbyqxmd.com/read/27916079/-role-and-mechanism-of-th17-treg-in-obstructive-sleep-apnea-hypopnea-syndrome
#1
Y Liu, Y C Gu, Y Tang, X L Lü, H Chen, Q Z Wu
Objective: To explore the role and the mechanism of Th17/Treg in obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: A total of 100 patients who completed polysomnography (PSG) in the sleep lab of Affiliated Wujiang Hospital of Nantong University from Mar. 2015 to Apr. 2016 were enrolled and divided into four groups (primary snoring as the control group, mild OSAHS, moderate OSAHS and severe OSAHS) according apnea hypopnea index (AHI). The proportion of Th17, Treg (of CD4(+) T cells) and the expression of interleukin (IL)-17A, IL-6 were detected and the relevant data were analyzed by the correlation analysis and the multiple stepwise regression analysis...
November 29, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27916076/-daytime-hypercapnia-in-patients-with-obstructive-sleep-apnea-hypopnea-syndrome-in-han-and-uygur-nationality
#2
Z M He, X L Jiang, Piliqing Da, Z Ye, J P Li, Q L Zhang, Y Chen, J Shi, M Li, F Han
Objective: To evaluate the incidence and factors related to daytime hypercapnia in Han and Uygur patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: There were 221 patients with OSAHS (include 179 Han patients and 42 Uygur patients) in Sleep Center of Department of Respiratory and Critical Care Medicine of Karamay Central Hospital from 2015, Jan to Dec. All the patients underwent polysomnography (PSG), nocturnal oximetry, daytime blood gas analysis, pulmonary function test and Mouth occlusion pressure (P0...
November 29, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27909886/automatic-snoring-sounds-detection-from-sleep-sounds-via-multi-features-analysis
#3
Can Wang, Jianxin Peng, Lijuan Song, Xiaowen Zhang
Obstructive sleep apnea hypopnea syndrome (OSAHS) is a serious respiratory disorder. Snoring is the most intuitively characteristic symptom of OSAHS. Recently, many studies have attempted to develop snore analysis technology for diagnosing OSAHS. The preliminary and essential step in such diagnosis is to automatically segment snoring sounds from original sleep sounds. This study presents an automatic snoring detection algorithm that detects potential snoring episodes using an adaptive effective-value threshold method, linear and nonlinear feature extraction using maximum power ratio, sum of positive/negative amplitudes, 500 Hz power ratio, spectral entropy (SE) and sample entropy (SampEn), and automatic snore/nonsnore classification using a support vector machine...
December 1, 2016: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/27866527/-association-between-daytime-sleepiness-and-hypertension-among-patients-with-obstructive-sleep-apnea-hypopnea-syndrome
#4
L N Du, R Ren, L Tan, T M Li, F Lei, X D Tang, L H Yang
Objective: To assess the association between daytime sleepiness and hypertension among patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods: A total of 1 958 patients from Sleep Medicine Center of West China Hospital between January 2015 and January 2016 were included in the study. All subjects underwent one night polysomnography (PSG) and Epworth sleep scale (ESS) was estimated. The patients were divided into non-OSAHS group[apnea-hypopnea index (AHI)<5/h]and OSAHS group (AHI≥5/h) based on PSG, and then OSAHS group was further divided into those with and without daytime sleepiness groups according to ESS score (the cut point of ESS was 14)...
November 15, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27852364/-the-expression-of-macrophage-migration-inhibitory-factor-in-obstructive-sleep-apnea-hypopnea-syndrome-and-its-injury-to-endothelial-cells
#5
P Yuan, W J Wang, D F Li, Q Ou, X L Gao
Objective: To study the expression of macrophage migration inhibitory factor (MIF) in obstructive sleep apnea hypopnea syndrome (OSAHS) and its injury to endothelial cells. Methods: According to the PSG test results, subjects who were the first time to take PSG examination without treatment (n=71) were divided into a control group (n=20), a mild OSAHS group (n=19), a moderate OSAHS group (n=15) and severe OSAHS group (n=17). For each patients, 4 ml fasting peripheral blood was obtained when PSG was finished around 6: 30 in the next morning, and the MIF level in plasma was detected with the ELISA method...
November 12, 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27817812/neurocognitive-impairment-is-correlated-with-oxidative-stress-in-patients-with-moderate-to-severe-obstructive-sleep-apnea-hypopnea-syndrome
#6
Yanyu He, Rui Chen, Jing Wang, Wenying Pan, Yanqiu Sun, Fei Han, Qiaojun Wang, Chunfeng Liu
BACKGROUND AND OBJECTIVES: Patients with obstructive sleep apnea hypopnea syndrome (OSAHS) are associated with increased risk of neurocognitive impairment, which are largely recognized as mild cognitive impairment (MCI), and oxidative stress is postulated as one of the underlying mechanisms. This study aimed to investigate the relationship between MCI and oxidative stress biomarkers in OSAHS. METHODS: A total of 119 middle-aged patients with moderate-to-severe OSAHS were included...
November 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27809898/efficacy-and-mechanism-of-mandibular-advancement-devices-for-persistent-sleep-apnea-after-surgery-a-prospective-study
#7
Huiping Luo, Xulan Tang, Yuanping Xiong, Lili Meng, Hongliang Yi, Shankai Yin
BACKGROUND: To explore the feasibility, the efficacy, and the mechanism of mandibular advancement devices (MAD) in the treatment of persistent sleep apnea after surgery. METHODS: Nineteen patients who failed uvulopalatopharyngoplasty (UPPP) or UPPP plus genioglossus advancement and hyoid myotomy (GAHM) were given a non-adjustable MAD for treatment. All patients had polysomnography (PSG) at least 6 months post-UPPP with and without the MAD. Seventeen patients had computed tomography (CT) examinations...
November 3, 2016: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27807693/reliability-of-drug-induced-sedation-endoscopy-interobserver-agreement
#8
Marina Carrasco-Llatas, Vanessa Zerpa-Zerpa, José Dalmau-Galofre
PURPOSE: Several studies have demonstrated the validity, reliability, and safety of drug-induced sedation endoscopy (DISE) in assessing the collapse of the upper airway (UA) in patients with obstructive sleep apnea hypoapnea syndrome (OSAHS). The aim of this study was to assess the interobserver agreement on DISE and on therapeutic decision between an expert observer and an observer in training. METHODS: This was a cross-sectional study. Thirty-one DISE videos performed in our service were randomly selected...
November 3, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27796718/continuous-positive-airway-pressure-usage-in-hospitalized-patients-with-known-obstructive-sleep-apnea-discrepancy-between-admission-pressure-settings-and-laboratory-determined-settings
#9
Parmeet Saini, Emile Klada, Vishal Patel, Moe Zaw, Boris Dubrovsky, Liziamma George, Elizabeth M Bachman, Jeremy A Weingarten
PURPOSE: The aim of this study was to determine the frequency and predictors of correctly initiated continuous positive airway pressure (CPAP) settings on the initial night of hospitalization in patients with known obstructive sleep apnea-hypopnea syndrome (OSAHS). METHODS: Hospital records of all patients who underwent an outpatient therapeutic polysomnogram (PSG) at our institution between January 2005 and December 2010 were retrospectively reviewed. Data collected included initial CPAP settings on hospital admission, latency to hospitalization (from sleep study), hospital length of stay, demographic variables, and PSG variables...
October 29, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27754829/potential-inflammatory-markers-in-obstructive-sleep-apnea-hypopnea-syndrome
#10
Dongmei Lu, Nanfang Li, Xiaoguang Yao, Ling Zhou
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a complex chronic inflammatory respiratory disease with multiple pathogenic factors and high morbidity and mortality. Serum levels of nuclear factor-κB (NF-κB), hypoxia-inducible factor-1 alpha (HIF-1α), and surfactant protein D (SPD) were investigated in OSAHS patients, to determine their clinical significance and correlation with the pathogenesis. Patients were classified into a mild and moderate OSAHS group (n = 25) and severe OSAHS group (n = 33). Twenty healthy patients served as a control group...
October 18, 2016: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27688168/effects-of-surgical-correction-of-class-iii-malocclusion-on-the-pharyngeal-airway-and-its-influence-on-sleep-apnoea
#11
J V Dos S Canellas, H L M Barros, P J D Medeiros, F G Ritto
The objective of this study was to evaluate, through cone beam computed tomography, the immediate changes in pharyngeal airway space (PAS) after orthognathic surgery in class III patients, and to determine the influence of surgery on the development of obstructive sleep apnoea hypopnoea syndrome (OSAHS). A prospective study was conducted; 33 patients were divided into three groups: mandibular setback surgery (nine patients), bimaxillary surgery (18 patients), and maxillary advancement surgery (six patients)...
September 26, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27672073/obstructive-sleep-apnea-syndrome-and-hypothyroidism-merely-concurrence-or-causal-association
#12
Wojciech Kuczyński, Agata Gabryelska, Łukasz Mokros, Piotr Białasiewicz
The prevalence of obstructive sleep apnea-hypopnea syndrome (OSAHS) ranges from 4 to 7% in men and from 2 to 5% in women. Its deleterious consequences such as traffic accidents, cardiovascular complications increasing morbidity and mortality, make it a major health problem. Apart from obesity (a major risk factor for OSAHS), hypothyroid patients are prone to reveal this phenotype. Although hypothyroidism seems an acknowledged risk factor for OSAHS, some authors report the lack of clinically relevant association...
2016: Pneumonologia i Alergologia Polska
https://www.readbyqxmd.com/read/27669996/-how-to-characterize-and-treat-sleep-complaints-in-bipolar-disorders
#13
P A Geoffroy, J-A Micoulaud Franchi, R Lopez, I Poirot, A Brion, S Royant-Parola, B Etain
OBJECTIVES: Sleep complaints are very common in bipolar disorders (BD) both during acute phases (manic and depressive episodes) and remission (about 80 % of patients with remitted BD have poor sleep quality). Sleep complaints during remission are of particular importance since they are associated with more mood relapses and worse outcomes. In this context, this review discusses the characterization and treatment of sleep complaints in BD. METHODS: We examined the international scientific literature in June 2016 and performed a literature search with PubMed electronic database using the following headings: "bipolar disorder" and ("sleep" or "insomnia" or "hypersomnia" or "circadian" or "apnoea" or "apnea" or "restless legs")...
September 23, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27651190/-influencing-factors-of-renal-function-in-hypertensive-patients-with-obstructive-sleep-apnea-hypopnea-syndrome
#14
Jiang Qianqian, Zhulepiya Simayi, Chen Yulan, Zhou Xiaohuan, Zhang Xiangyang, X U Xinjuan, Y E Hong
OBJECTIVE: To investigate the related factors of renal functions in hypertensive patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). METHODS: A total of 438 hypertensive patients with complain of snoring at night were enrolled in the study from the First teaching Hospital of Xinjiang Medical University during March 2011 and March 2014. The diagnosis of OSAHS was confirmed with polysomnography examination, and the patients were divided into 4 groups according to the apnea hypoventilation index (AHI): hypertensive group (AHI<10/h, n=102), mild OSAHS group (AHI 10-<15/h, n=97), moderate OSAHS group (AHI 15-<30/h, n=149), and severe OSAHS group (AHI≥30/h, n=90)...
May 25, 2016: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/27609729/relationship-of-symptoms-with-sleep-stage-abnormalities-in-obstructive-sleep-apnea-hypopnea-syndrome
#15
Md Basunia, Samir A Fahmy, Frances Schmidt, Chidozie Agu, Bikash Bhattarai, Vikram Oke, Danilo Enriquez, Joseph Quist
BACKGROUND: Patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) present with a variety of sleep-related symptoms. In polysomnography, sleep architecture is almost always abnormal, but it is not known which of the sleep-stage abnormalities are related to symptoms. Finding key sleep-stage abnormality that cause symptoms may be of therapeutic importance to alleviate symptoms. So far the mainstay of treatment is continuous positive airway pressure (CPAP)/bi-level positive airway pressure (BIPAP) therapy, but many patients are non-compliant to it...
2016: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/27602807/pressure-monitoring-of-the-mueller-maneuver-our-experience-in-twenty-five-obstructive-sleep-apnea-hypopnoea-syndrome-patients-with-oropharyngeal-obstruction
#16
Jacopo Cambi, Paola Staffa, Maria Carla Spinosi
Obstructive Sleep Apnea Hypopnoea Syndrome (OSAHS) is a common disorder characterized by partial (hypopnoea) or total (apnea) closure of the upper airways during sleep. It is associated with hypertension, stroke, car accidents, diabetes, metabolic syndrome and depression. Although this disease is related to major morbidity and mortality(1) , the prevalence of OSAHS is underestimated. The physiopathology of OSAHS is multifactorial and not yet fully understood. Numerous pathophysiological risk factors have been recognized: anatomical abnormalities, impaired upper airway dilators, unstable respiratory control and diminished arousal threshold...
September 7, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27588078/treatment-and-prevention-of-inflammatory-responses-and-oxidative-stress-in-patients-with-obstructive-sleep-apnea-hypopnea-syndrome-using-chinese-herbal-medicines
#17
Qin Chen, Rong Jing Lin, Xuchu Hong, Lin Ye, Qichang Lin
The present study aimed to investigate the therapeutic effects of Chinese herbal medicines for the treatment and prevention of inflammatory responses and oxidative stress in obstructive sleep apnea hypopnea syndrome (OSAHS). A total of 60 patients with OSAHS were randomly divided into two groups (n=30/group): The experimental group, who received the conventional treatment + oral administration of the traditional Chinese herbal formula, Jiawei Di Tan Tang; and the control group, who received the conventional treatment only...
September 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27581116/how-does-serum-brain-natriuretic-peptide-level-change-under-nasal-continuous-positive-airway-pressure-in-obstructive-sleep-apnea-hypopnea-syndrome
#18
Sameh Msaad, Rim Marrakchi, Malek Grati, Rahma Gargouri, Samy Kammoun, Kamel Jammoussi, Ilhem Yangui
BACKGROUND: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is associated with cardiovascular morbidity and mortality, which can be improved by using continuous positive airway pressure (CPAP) therapy. However, the pathophysiological links between the two kinds of disease and the mechanism of the CPAP effect remain incompletely understood. We aimed to inquire into the myocardial involvement in this relationship. We suggested that serum brain natriuretic peptide (BNP) is sensitive enough to detect myocardial stress caused by OSAHS...
2016: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/27523891/-serum-%C3%AE-glutamyltransferase-in-obstructive-sleep-apnea-hypopnea-syndrome-and-its-role-in-predicting-concomitant-diabetes-mellitus
#19
C J Gu, M Li, Q Y Li, J Zhou, J Du, H H Yi, J Feng, J P Zhou
OBJECTIVE: To determine the association of obstructive sleep apnea hypopnea syndrome(OSAHS) with serum γ-glutamyltransferase(γ-GT) and whether serum γ-GT is an independent predictor for diabetes mellitus(DM) in OSAHS patients. METHODS: A total of 172 Han Chinese subjects were enrolled and divided into three groups based on full-night polysomnography(PSG): severe OSAHS group(AHI>30 events/h), mild to moderate OSAHS group (5<AHI≤30 events/h) and control group(AHI<5 events/h)...
August 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27515504/detection-and-analysis-of-apoptosis-and-autophagy-related-mirnas-of-vascular-endothelial-cells-in-a-mouse-chronic-intermittent-hypoxia-model
#20
Kai-Xiong Liu, Gong-Ping Chen, Ping-Li Lin, Jian-Chai Huang, Xin Lin, Jia-Chao Qi, Qi-Chang Lin
Endothelial dysfunction is the main pathogenic mechanism of cardiovascular complications induced by obstructive sleep apnea/hypopnea syndrome (OSAHS). Chronic intermittent hypoxia (CIH) is the primary factor of OSAHS-associated endothelial dysfunction. The hypoxia inducible factor (HIF) pathway regulates the expression of downstream target genes and mediates cell apoptosis caused by CIH-induced endothelial injury. miRNAs play extensive and important negative regulatory roles in this process at the post-transcriptional level...
August 8, 2016: Life Sciences
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