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https://www.readbyqxmd.com/read/29145148/honokiol-protects-pancreatic-%C3%AE-cell-against-high-glucose-and-intermittent-hypoxia-induced-injury-by-activating-nrf2-are-pathway-in-vitro-and-in-vivo
#1
Chen-Guang Li, Chang-Lin Ni, Min Yang, Yun-Zhao Tang, Zhu Li, Yan-Juan Zhu, Zhen-Huan Jiang, Bei Sun, Chun-Jun Li
Obstructive sleep apnea hypopnea syndrome (OSAHS) is associated with glucose intolerance, insulin resistance and type 2 diabetes mellitus (T2DM). Although several studies have revealed that intermittent hypoxia (IH) in OSAHS may further aggravate pancreatic β cell damage and promote the evolution of type 2 diabetes (T2DM) by increasing oxidative stress, the underlying mechanisms are unclear. Honokiol, a potent radical scavenger, has been demonstrated to ameliorate oxidative stress in many cases. The present study aimed to explore the potential mechanism of IH and diabetes synergistically damage and destruct the pancreatic β cell, examine the effects of honokiol on ameliorating pancreatic β cell injury in this context and explore the mechanism of such effects...
November 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29130961/endothelial-cell-derived-microparticles-from-patients-with-obstructive-sleep-apnea-hypoxia-syndrome-and-coronary-artery-disease-increase-aortic-endothelial-cell-dysfunction
#2
Lixin Jia, Jingyao Fan, Wei Cui, Sa Liu, Na Li, Wayne Bond Lau, Xinliang Ma, Jie Du, Shaoping Nie, Yongxiang Wei
BACKGROUND/AIMS: Obstructive sleep apnea hypoxia syndrome (OSAHS) is an independent risk factor for coronary artery disease (CAD). Treatment of OSAHS improves clinical outcome in some CAD patients, but the relationship between OSAHS and CAD is complex. Microparticles (MPs) are shed by the plasma membrane by either physiologic or pathologic stimulation. In the current study, we investigated the role of MPs in the context of OSAHS. METHODS AND RESULTS: 54 patients with both suspected coronary artery stenosis and OSAHS were recruited and underwent both coronary arteriography and polysomnography...
November 1, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29129750/k-complex-morphological-features-in-male-obstructive-sleep-apnea-hypopnea-syndrome-patients
#3
Lin Sun, Xiangmin Zhang, Shaoxiong Huang, Jiuxing Liang, Yuxi Luo
This study characterized the differences in K-complex (KC) morphology features between obstructive sleep apnea-hypopnea syndrome (OSAHS) patients and healthy controls and analyzed the effect of respiratory events on KC morphology. We enrolled 42 male subjects (21 OSAHS patients and 21 age-matched healthy controls) who underwent overnight polysomnography. KCs in stage N2 were manually identified. We found that KCs in healthy controls had larger negative and whole amplitudes, longer durations, and smoother positive waves than OSAHS patients but smaller positive amplitudes...
November 9, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29122399/-sleep-apneas-metabolic-syndrome-and-cardiovascular-risk-data-from-the-pays-de-la-loire-sleep-cohort
#4
REVIEW
F Gagnadoux, P Priou, T Urban, N Meslier, W Trzepizur
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a prevalent disease characterized by recurrent episodes of partial or complete obstruction of upper airway during sleep. Untreated moderate to severe OSAHS is recognized as a cardiovascular (CV) risk factor. Data from the Pays de la Loire sleep cohort and other clinic- or population-based cohorts demonstrate a strong association between OSAHS and the different components of the metabolic syndrome including systemic hypertension, diabetes and impaired lipid metabolism...
November 6, 2017: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/29108914/detection-and-analysis-of-apoptosis-and-autophagy-related-mirnas-of-mouse-vascular-endothelial-cells-in-chronic-intermittent-hypoxia-model
#5
Kai-Xiong Liu, Gong-Ping Chen, Ping-Li Lin, Jian-Chai Huang, Xin Lin, Jia-Chao Qi, Qi-Chang Lin
Endothelial dysfunction is the main pathogenic mechanism of cardiovascular complications induced by obstructive sleep apnea/hyponea syndrome (OSAHS). Chronic intermittent hypoxia (CIH) is the primary factor of OSAHS-associated endothelial dysfunction. The hypoxia inducible factor (HIF) pathway regulates the expression of downstream target genes and mediates cell apoptosis caused by CIH-induced endothelial injury. miRNAs play extensive and important negative regulatory roles in this process at the post-transcriptional level...
November 3, 2017: Life Sciences
https://www.readbyqxmd.com/read/29107556/-blood-pressure-and-sleep-apnoea-hypopnoea-syndrome-in-workers-stop-bang-test-versus-epworth-test
#6
M T Vicente-Herrero, L Capdevila-García, M C Bellido-Cambrón, M V Ramírez-Iñiguez de la Torre, S Lladosa-Marco
INTRODUCTION: OSAHS is associated with an increased risk of cardiovascular disease and stroke. Arterial hypertension is a key risk factor to consider due to its impact on health. METHOD: Cross-sectional study carried out on Spanish public service workers. The nocturnal apnoea risk using the Epworth and STOP-Bang questionnaires and their influence on the mean values of blood pressure are assessed. RESULTS: The detection of OSAHS using the Epworth test and, particularly with the STOP-Bang shows a significant relationship with the mean values of blood pressure, with differences between both questionnaires...
October 26, 2017: Hipertensión y Riesgo Vascular
https://www.readbyqxmd.com/read/29058247/therapeutic-effects-of-different-drugs-on-obstructive-sleep-apnea-hypopnea-syndrome-in-children
#7
Jing Zhang, Jie Chen, Yong Yin, Lei Zhang, Hao Zhang
BACKGROUND: This study aimed to compare the therapeutic effects of different drugs on obstructive sleep apnea/hypopnea syndrome (OSAHS) in children by using a network meta-analysis approach. METHODS: PubMed, Embase and Cochrane Library were searched from the inception of each database to November 2015. Randomized controlled trials (RCTs) concerning the comparisons in the therapeutic effects of eight placebo-controlled drugs on OSAHS in children were included in this study...
December 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29050104/-hypoglossal-nerve-stimulation-therapy-for-obstructive-sleep-apnea-hypopnea-syndrome
#8
Q Yan, B Guan
Obstructive sleep apnea hypopnea syndrome(OSAHS) is a clinical and critical disease to health, which the accuratly pathogenesis is not very explicit. The mainstream research suggested that dysfunction of upper airway dilator muscles is one of the hazard factors. Genioglossus innervated by the hypoglossal nerve plays crucial roles. It could expand volume of pharyngeal cavity, and increase airflow rate when stimulate it.With the development of anatomy and physiology, hypoglossal nerve stimulation(HGNS) entered into clinical trials, and had made tremendous progress since 2001...
October 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29049225/factors-related-to-pediatric-obstructive-sleep-apnea-hypopnea-syndrome-in-children-with-attention-deficit-hyperactivity-disorder-in-different-age-groups
#9
Jiali Wu, Meizhen Gu, Shumei Chen, Wei Chen, Kun Ni, Hongming Xu, Xiaoyan Li
This study aimed to retrospectively investigate the factors related to pediatric obstructive sleep apnea-hypopnea syndrome (OSAHS) with attention deficit hyperactivity disorder (ADHD) in children younger than 6 years and those older than 6 years.A total of 437 children who were hospitalized due to OSAHS between January 2014 and December 2014 were retrospectively reviewed. The children were further divided into OSAHS group and OSAHS + ADHD group. The general characteristics, OSA-18 quality of life, intention-hyperactivity score, and polysomnographic parameters (apnea-hypopnea index and the lowest oxygen saturation) were collected and compared between groups...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29036480/treatment-of-obstructive-sleep-apnoea-hypopnea-syndrome-by-mandible-advanced-device-reduced-neuron-apoptosis-in-frontal-cortex-of-rabbits
#10
Hai-Yan Lu, Wen Wang, Zheng Zhou, Chun-Yan Liu, Ye Liu, Wei Xiao, Fu-Sheng Dong, Jie Wang
Objective: To investigate effects of mandible advanced device (MAD) therapy for obstructive sleep apnoea-hypopnea syndrome (OSAHS) on the neuron apoptosis and acetylcholine esterase activity in frontal cortex. Materials and methods: Thirty male New Zealand white rabbits were randomly divided into three groups (n = 10 in each group): group OSAHS, group MAD, and control group. Hydrophilic polyacrylamide gel was injected into soft palate of the animals to induce OSAHS in group OSAHS and group MAD...
September 23, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28990830/value-of-pulse-oximetry-watch-for-diagnosing-pediatric-obstructive-sleep-apnea-hypopnea-syndrome
#11
Jing-Ru Ma, Jing-Jing Huang, Qi Chen, Hai-Tao Wu, Kuan-Lin Xiao, Yu-Tian Zhang
OBJECTIVE: To evaluate the clinical value of pulse oximetry watch (POW) for diagnosing pediatric Obstructive sleep apnea/hypopnea syndrome (OSAHS). METHODS: We selected 32 children (boys: 25, 4-16 years old) who came to the hospital for diagnosing OSAHS from July to October 2016. Polysomnography (PSG) and POW were used simultaneously and recorded the apnea hypopnea index (AHI), LSpO2, and ODI4. Pearson analysis, t test, and receiver-operating characteristic (ROC) were used to analyze the correlation between PSG-AHI and other indicators, the diagnosis accordance rate, and the sensitivity and specificity of POW, respectively...
October 9, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28981208/prospective-multicentre-study-on-barbed-reposition-pharyngoplasty-standing-alone-or-as-a-part-of-multilevel-surgery-for-sleep-apnoea
#12
F Montevecchi, G Meccariello, E Firinu, M S Rashwan, M Arigliani, M De Benedetto, A Palumbo, Y Bahgat, A Bahgat, R Lugo Saldana, A Marzetti, L Pignataro, M Mantovani, V Rinaldi, M Carrasco, F Freire, I Delgado, F Salamanca, A Bianchi, M Onerci, P Agostini, L Romano, M Benazzo, P Baptista, F Salzano, I Dallan, S Nuzzo, C Vicini
OBJECTIVES: The aim of this study was to demonstrate in a prospective multicentre study that Barbed Reposition Pharyngoplasty (BRP) procedure is safe and effective in management of obstructive sleep apnoea/hypopnea syndrome (OSAHS) patients. DESIGN: Prospective study. SETTING: Multicentre study. PARTICIPANTS: Patients suffering from obstructive sleep apnoea. MAIN OUTCOMES MEASURES: Values of postoperative apnoea-hypopnea index (AHI), oxygen desaturation index (ODI), epworth sleepiness scale (ESS)...
October 5, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28952010/cardiopulmonary-coupling-analysis-using-home-sleep-monitoring-system-based-on-air-mattress
#13
Jong-Uk Park, Erdenebayar Urtnasan, Eun-Yeon Joo, Kyoung-Joung Lee
This study investigates the feasibility of cardiopulmonary coupling (CPC) using home sleep monitoring system. We have designed a system to measure respiratory signals and normal-to-normal (NN) interval series in a non-contact based on air mattress. Then, CPC analysis was conducted using extracted respiratory signals and NN interval series, and six CPC parameters were extracted (VLFC, LFC, HFC, e-LFC, e-LFCNB and e-LFCBB). To evaluate the proposed method, two statistical analyses were conducted between the CPC parameters extracted by the electrocardiogram-based conventional method and the air mattress-based proposed method for five patients with obstructive sleep apnea and hypopnea (OSAH)...
September 26, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28924439/corneal-neovascularization-with-associated-lipid-keratopathy-in-a-patient-with-obstructive-sleep-apnea-hypopnea-syndrome-using-a-continuous-positive-airway-pressure-machine
#14
Konstantinos Oikonomakis, Myrsini Petrelli, Konstantinos Andreanos, Andreas Mouchtouris, Petros Petrou, Ilias Georgalas, Dimitrios Papaconstantinou, George Kymionis
OBJECTIVE: To report a case of corneal neovascularization with secondary lipid keratopathy in a patient treated with continuous positive airway pressure (CPAP) for obstructive sleep apnea-hypopnea syndrome (OSAHS). CASE REPORT: A 49-year-old male had been diagnosed with obstructive sleep apnea syndrome 10 years ago and has been treated with the application of a CPAP machine during night sleep ever since. For the past year, the patient had been complaining for ocular irritation and excessive tearing of the left eye on awakening...
May 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28912855/effect-of-transoral-endoscopic-adenoidectomy-on-peripheral-blood-t-lymphocyte-subsets-in-children-with-obstructive-sleep-apnea-hypopnea-syndrome-and-its-treatment-strategy
#15
Na Yang, Yaofeng Ji, Yin Liu
The objective of the present study was to investigate the effect of transoral endoscopic adenoidectomy on peripheral blood T lymphocyte subsets in pediatric patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and its treatment strategy. Ninety-eight pediatric patients with adenoidal hypertrophy associated with OSAHS admitted to the Department of Otolaryngology, Xuzhou Children's Hospital were selected. After admission, patients received perfected 24 h polysomnogram monitoring, routine blood examination, fasting blood biochemistry examination, T-lymphocyte subset count, 24 h ambulatory blood pressure monitoring, and nasopharyngeal computed tomography...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28910915/-assessment-of-sleep-disordered-breathing-using-hypoxia-index
#16
Y X Du, Y M Zeng, Z B Zhou, L M Huang
Objective: To analyze the clinical significance of hypoxia index (HI) in assessing the severity of hypoxemia in obstructive sleep apnoea hypopnea syndrome(OSAHS). Methods: A total of 127 patients with a complaint of snoring visiting our hospital were recruited from February 2014 to January 2016. All patients received polysomnography (PSG) test. The PSG results were analyzed by a technician and the SpO(2) data were analyzed by a pre-designed computer software. The patients were grouped according to apnea hypopnea index (AHI) and lowest oxygen saturation (LSpO(2)) respectively...
September 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28910892/-study-on-pharyngeal-wall-floppiness-of-patients-with-obstructive-sleep-apnea-hypopnea-syndrome-attributable-to-non-structural-factors
#17
Z Q Lin, K L Jiang, L Zhao, S N Li, S Shao, W Qian, Z Z Tao
Objective: Acoustic pharyngealmetry technology is utilized to evaluate the change and clinical significance of obstructive sleep apnea-hypopnea syndrome (OSAHS) patients caused by non-upper airway structural factor and normal individuals' PWF(pharyngeal wall floppiness). Methods: Acoustic pharyngealmetry instrument of Ecconvision was utilized to examine 102 OSAHS patients and 50 normal individuals, separately recorded their volume of pharyngeal cavity in sit or supine position, calculated PWF in sit or supine position, and SPSS 12...
September 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28910165/peripapillary-choroidal-thickness-and-retinal-nerve-fiber-layer-in-untreated-patients-with-obstructive-sleep-apnea-hypopnea-syndrome-a-case-control-study
#18
Serpil Yazgan, Fatma Erboy, Haci Ugur Celik, Tacettin Ornek, Suat Hayri Ugurbas, Firuzan Kokturk, Orhan Ayar, Mehmet Orcun Akdemir, Erkan Celik
PURPOSE: To evaluate peripapillary choroidal thickness (PPCT), central macular choroidal thickness (CMCT), and retinal nerve fiber layer (RNFL) thickness in untreated patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). METHODS: This prospective, randomized, and comparative study was conducted in a university ophthalmology clinic. 106 eyes of 106 patients with OSAHS and 44 eyes of 44 healthy individuals were evaluated in this study. Only right eyes were evaluated...
November 2017: Current Eye Research
https://www.readbyqxmd.com/read/28901388/inhibitory-effects-of-17%C3%AE-estradiol-or-a-resveratrol-dimer-on-hypoxia-inducible-factor-1%C3%AE-in-genioglossus-myoblasts-involvement-of-er%C3%AE-and-its-downstream-p38%C3%A2-mapk-pathways
#19
Yuanyuan Li, Yuehua Liu, Yun Lu, Bingjiao Zhao
Deficiency in the functioning of the genioglossus, which is one of the upper airway dilator muscles, is an important cause of obstructive sleep apnea/hypopnea syndrome (OSAHS). Estrogens have been reported to inhibit hypoxia-inducible factor-1α (HIF-1α) expression in hypoxia, regulating its target genes and exerting protective effects on the genioglossus in chronic intermittent hypoxia (CIH). This study aimed to investigate the role of 17β-estradiol (E2) and a resveratrol dimer (RD) on HIF-1α and the underlying mechanism...
November 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28884388/circulating-c3-and-glucose-metabolism-abnormalities-in-patients-with-osahs
#20
Xiaoxia Lu, Xiao Wang, Ting Xu, Yuan Feng, Yufeng Wang, Zechuan Cai, Bing Cao, Taoping Li
PURPOSE: Obstructive sleep apnea hypopnea syndrome (OSAHS) is a common breathing disorder during sleep characterized by multiple disease roots, including disorders of complement and glycometabolism. And the main purpose of the present study is to make clear the effect of complement C3 on glucose metabolism abnormalities in patients with OSAHS. METHODS: This was a cross-sectional study. Two hundred six patients, mean age 44.58 ± 11.84 years and 26 female patients (26/206), had been suspected with OSAHS and underwent overnight polysomnography...
September 7, 2017: Sleep & Breathing, Schlaf & Atmung
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