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https://www.readbyqxmd.com/read/27906176/epigenetic-programming-of-dnmt3a-mediated-by-ap2%C3%AE-is-required-for-granting-preadipocyte-the-ability-to-differentiate
#1
Wei Guo, Jiangnan Chen, Ying Yang, Jianbei Zhu, Jiarui Wu
Adipogenesis has an important role in regulating energy homeostasis in mammals. 3T3-L1 preadipocytes have been widely used as an in vitro model for analyzing the molecular mechanism of adipogenesis. Previous reports indicated that the stage of contact inhibition (CI), through which the proliferating cells exit from the cell cycle, was required for granting preadipocyte the ability to differentiate. While this kind of the granting mechanism remains elusive. In the present study, we showed that DNA (cytosine-5) methyltransferase 3a (Dnmt3a) was upregulated at both the mRNA and protein level during the CI stage, and resulted in increasing promoter methylation of adipogenic genes...
December 1, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27898839/ap2-erf-transcription-factors-involved-in-response-to-tomato-yellow-leaf-curly-virus-in-tomato
#2
Ying Huang, Bao-Long Zhang, Sheng Sun, Guo-Ming Xing, Feng Wang, Meng-Yao Li, Yong-Sheng Tian, Ai-Sheng Xiong
Tomato yellow leaf curly virus (TYLCV), transmitted by the whitefly (), causes leaf curling and yellowing, plant dwarfism, and growth inhibition in tomato ( L.). The APETALA2 (AP2) and ethylene response factor (ERF) transcription factor (TF) family, the largest plant-specific TF family, was identified to function in plant development and pathogen defense. Our study aimed to analyze the mechanism underlying the function of ERF (SlERF) TFs in response to TYLCV infection and improve useful information to increase the resistance to TYLCV in tomato...
July 2016: Plant Genome
https://www.readbyqxmd.com/read/27898817/genome-wide-identification-of-the-ap2-erf-gene-family-involved-in-active-constituent-biosynthesis-in
#3
A J Ji, H M Luo, Z C Xu, X Zhang, Y J Zhu, B S Liao, H Yao, J Y Song, S L Chen
Tanshinones and phenolic acids are the major bioactive constituents in the traditional medicinal crop ; however, transcription factors (TFs) are seldom investigated with regard to their regulation of the biosynthesis of these compounds. Here a complete overview of the APETALA2/ethylene-responsive factor (AP2/ERF) transcription factor family in is provided, including phylogeny, gene structure, conserved motifs, and gene expression profiles of different organs (root, stem, leaf, flower) and root tissues (periderm, phloem, xylem)...
July 2016: Plant Genome
https://www.readbyqxmd.com/read/27868125/coumestrol-modulates-akt-and-wnt-%C3%AE-catenin-signaling-during-the-attenuation-of-adipogenesis
#4
Young Jin Jang, Hyo Jeong Son, Jiyun Ahn, Chang Hwa Jung, Taeyoul Ha
Coumestrol is a natural phytochemical present in plants such as red clover and soy, and has been reported to stimulate the estrogen receptor as a major phytoestrogen. While the molecular mechanisms responsible for the anti-adipogenic effects of phytoestrogens such as genistein and daidzein have been previously investigated, the effects of coumestrol on adipogenesis remain to be elucidated. We observed that coumestrol dose-dependently attenuates MDI (mixture of 3-isobutyl-1-methylxanthine, dexamethasone, and insulin)-induced lipid accumulation, consistent with an earlier study, while significantly inhibiting MDI-induced adipogenesis in the first 48 hours of differentiation, a critical time window for anti-adipogenic effects...
November 21, 2016: Food & Function
https://www.readbyqxmd.com/read/27867269/platyphylloside-isolated-from-betula-platyphylla-inhibit-adipocyte-differentiation-and-induce-lipolysis-via-regulating-adipokines-including-ppar%C3%AE-in-3t3-l1-cells
#5
Mina Lee, Sang Hyun Sung
BACKGROUND: Obesity causes or aggravates many health problems, both independently and in association with several pathological disorders, including Type II diabetes, hypertension, atherosclerosis, and cancer. Therefore, we screened small compounds isolated from natural products for the development of anti-obesity drugs. OBJECTIVE: The purpose of this study was to investigate the anti-adipogenic activities of platyphylloside, diarylheptanoid isolated from Betula platyphylla, which was selected based on the screening using 3T3-L1 cells...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27845384/mutation-tendency-of-mutator-plasmodium-berghei-with-proofreading-deficient-dna-polymerase-%C3%AE
#6
Hajime Honma, Mamoru Niikura, Fumie Kobayashi, Toshihiro Horii, Toshihiro Mita, Hiroyoshi Endo, Makoto Hirai
In this study, we investigated the mutation tendency of a mutator rodent malaria parasite, Plasmodium berghei, with proofreading-deficient DNA polymerase δ. Wild-type and mutator parasites were maintained in mice for over 24 weeks, and the genome-wide accumulated mutations were determined by high-throughput sequencing. The mutator P. berghei had a significant preference for C/G to A/T substitutions; thus, its genome had a trend towards a higher AT content. The mutation rate was influenced by the sequence context, and mutations were markedly elevated at TCT...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27842501/analysis-of-transcriptional-response-to-heat-stress-in-rhazya-stricta
#7
Abdullah Y Obaid, Jamal S M Sabir, Ahmed Atef, Xuan Liu, Sherif Edris, Fotouh M El-Domyati, Mohammed Z Mutwakil, Nour O Gadalla, Nahid H Hajrah, Magdy A Al-Kordy, Neil Hall, Ahmed Bahieldin, Robert K Jansen
BACKGROUND: Climate change is predicted to be a serious threat to agriculture due to the need for crops to be able to tolerate increased heat stress. Desert plants have already adapted to high levels of heat stress so they make excellent systems for identifying genes involved in thermotolerance. Rhazya stricta is an evergreen shrub that is native to extremely hot regions across Western and South Asia, making it an excellent system for examining plant responses to heat stress. Transcriptomes of apical and mature leaves of R...
November 14, 2016: BMC Plant Biology
https://www.readbyqxmd.com/read/27833627/arg156-in-the-ap2-domain-exhibits-the-highest-binding-activity-among-the-20-individuals-to-the-gcc-box-in-bnaerf-b3-hy15-a-mutant-erf-transcription-factor-from-brassica-napus
#8
Jing Zhuang, Meng-Yao Li, Bei Wu, Yan-Jun Liu, Ai-Sheng Xiong
To develop mutants of the ERF factor with more binding activities to the GCC box, we performed in vitro directed evolution by using DNA shuffling and screened mutants through yeast one-hybrid assay. Here, a series of mutants were obtained and used to reveal key amino acids that induce changes in the DNA binding activity of the BnaERF-B3 protein. With the BnaERF-B3-hy15 as the template, we produced 12 mutants which host individual mutation of potential key residues. We found that amino acid 156 is the key site, and the other 18 mutants host the 18 corresponding individual amino acid residues at site 156...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27832060/comparative-bioinformatics-analysis-of-transcription-factor-genes-indicates-conservation-of-key-regulatory-domains-among-babesia-bovis-babesia-microti-and-theileria-equi
#9
REVIEW
Heba F Alzan, Donald P Knowles, Carlos E Suarez
Apicomplexa tick-borne hemoparasites, including Babesia bovis, Babesia microti, and Theileria equi are responsible for bovine and human babesiosis and equine theileriosis, respectively. These parasites of vast medical, epidemiological, and economic impact have complex life cycles in their vertebrate and tick hosts. Large gaps in knowledge concerning the mechanisms used by these parasites for gene regulation remain. Regulatory genes coding for DNA binding proteins such as members of the Api-AP2, HMG, and Myb families are known to play crucial roles as transcription factors...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27830680/-identification-and-characterization-of-ap2-erf-transcription-factors-in-moso-bamboo-phyllostachys-edulis
#10
Z Huang, X-J Zhong, J He, M-Y Jiang, X-F Yu, X Li
Bamboo belongs to subfamily Bambusoideae of the grass family and is one of the most important non-timber forest resources in the world. The AP2/ERF superfamily is a group of plant specific transcription factors and plays important roles in the regulation of plant growth and responses to biotic and abiotic stress. By comprehensively analyzing the recently uncovered whole genome sequence and full length cDNA of moso bamboo (Phyllostachys edulis), 142 AP2/ERF transcription factors were identified and 53 among them are supported by full length cDNA...
September 2016: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/27816829/small-family-big-impact-in-silico-analysis-of-dreb2-transcription-factor-family-in-rice
#11
Venura Herath
Dehydration-responsive element- (DREB) proteins are considered as the master regulators of plant abiotic stress responses including drought, salinity and cold. They are also involved in other developmental processes such as embryo and endosperm development. DREB family of transcription factors consist of two sub families namely CBF1/DREB1 and DREB2. In this study, a genome-wide in silico analysis was carried out to dissect the structure and function of DREB2 family transcription factors in the rice genome. Using Arabidopsis DREB2 sequences a total of five rice DREB2 homologs were identified and they were distributed among four chromosomes...
October 29, 2016: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/27814694/de-novo-transcriptome-sequencing-and-gene-expression-profiling-of-elymus-nutans-under-cold-stress
#12
Juanjuan Fu, Yanjun Miao, Linhui Shao, Tianming Hu, Peizhi Yang
BACKGROUND: Elymus nutans Griseb., is an important alpine perennial forage of Pooideae subfamily with strong inherited cold tolerance. To get a deeper insight into its molecular mechanisms of cold tolerance, we compared the transcriptome profiling by RNA-Seq in two genotypes of Elymus nutans Griseb. the tolerant Damxung (DX) and the sensitive Gannan (GN) under cold stress. RESULTS: The new E. nutans transcriptomes were assembled and comprised 200,520 and 181,331 transcripts in DX and GN, respectively...
November 4, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27814359/whole-transcriptome-selection-and-evaluation-of-internal-reference-genes-for-expression-analysis-in-protocorm-development-of-dendrobium-officinale-kimura-et-migo
#13
Hongqiang An, Qiankun Zhu, Wei Pei, Jing Fan, Yi Liang, Yihui Cui, Nan Lv, Wanjun Wang
Dendrobium officinale Kimu et Migo has increased many researchers' interest for its high medical and horticultural values and the molecular mechanism of its protocorm development remains unclear. In this study, 19 genes from 26 most stably expressed genes in whole transcriptome of protocorms and 5 housekeeping genes were used as candidate reference genes and screened with 4 application softwares (geNorm, NormFinder, BestKeeper and RefFinder). The results showed that a few reference genes could effectively normalize expression level of specific genes in protocorm development and the optimal top 2 reference genes were ASS and APH1L...
2016: PloS One
https://www.readbyqxmd.com/read/27810268/identification-and-characterization-of-micrornas-in-maize-endosperm-response-to-exogenous-sucrose-using-small-rna-sequencing
#14
Huanhuan Huang, Jiao Long, Lanjie Zheng, Yangping Li, Yufeng Hu, Guowu Yu, Hanmei Liu, Yinghong Liu, Zhi Huang, Junjie Zhang, Yubi Huang
Sucrose acts as a signaling molecule for genes critical to starch biosynthesis in maize endosperm. Previously, we showed that sucrose could regulate starch biosynthesis in maize via transcription factors. To better understand the complex regulation of starch biosynthesis, the 10days after pollination endosperm from Zea mays L. B73 inbred line was collected and treated with sucrose for small RNA sequencing. The sequencing results revealed that 24 known miRNAs and 190 novel miRNAs were significantly differentially expressed in response to sucrose...
November 1, 2016: Genomics
https://www.readbyqxmd.com/read/27807832/transcriptome-and-proteome-analyses-of-tnfaip8-knockdown-cancer-cells-reveal-new-insights-into-molecular-determinants-of-cell-survival-and-tumor-progression
#15
Timothy F Day, Rajshree R Mewani, Joshua Starr, Xin Li, Debyani Chakravarty, Habtom Ressom, Xiaojun Zou, Ofer Eidelman, Harvey B Pollard, Meera Srivastava, Usha N Kasid
Tumor necrosis factor-α-inducible protein 8 (TNFAIP8) is the first discovered oncogenic and an anti-apoptotic member of a conserved TNFAIP8 or TIPE family of proteins. TNFAIP8 mRNA is induced by NF-kB, and overexpression of TNFAIP8 has been correlated with poor prognosis in many cancers. Downregulation of TNFAIP8 expression has been associated with decreased pulmonary colonization of human tumor cells, and enhanced sensitivities of tumor xenografts to radiation and docetaxel. Here we have investigated the effects of depletion of TNFAIP8 on the mRNA, microRNA and protein expression profiles in prostate and breast cancers and melanoma...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27803322/s2-from-equine-infectious-anemia-virus-is-an-infectivity-factor-which-counteracts-the-retroviral-inhibitors-serinc5-and-serinc3
#16
Ajit Chande, Emilia Cristiana Cuccurullo, Annachiara Rosa, Serena Ziglio, Susan Carpenter, Massimo Pizzato
The lentivirus equine infectious anemia virus (EIAV) encodes the small protein S2, a pathogenic determinant that is important for virus replication and disease progression in horses. No molecular function had been linked to this accessory protein. We report that S2 can replace the activity of Negative factor (Nef) in HIV-1 infectivity, being required to antagonize the inhibitory activity of Serine incorporator (SERINC) proteins on Nef-defective HIV-1. Like Nef, S2 excludes SERINC5 from virus particles and requires an ExxxLL motif predicted to recruit the clathrin adaptor, Adaptor protein 2 (AP2)...
November 1, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27801944/a-differentially-regulated-ap2-erf-transcription-factor-gene-cluster-acts-downstream-of-a-map-kinase-cascade-to-modulate-terpenoid-indole-alkaloid-biosynthesis-in-catharanthus-roseus
#17
Priyanka Paul, Sanjay K Singh, Barunava Patra, Xueyi Sui, Sitakanta Pattanaik, Ling Yuan
Catharanthus roseus produces bioactive terpenoid indole alkaloids (TIAs), including the chemotherapeutics, vincristine and vinblastine. Transcriptional regulation of TIA biosynthesis is not fully understood. The jasmonic acid (JA)-responsive AP2/ERF transcription factor (TF), ORCA3, and its regulator, CrMYC2, play key roles in TIA biosynthesis. ORCA3 forms a physical cluster with two uncharacterized AP2/ERFs, ORCA4 and 5. Here, we report that (1) the ORCA gene cluster is differentially regulated; (2) ORCA4, while overlapping functionally with ORCA3, modulates an additional set of TIA genes...
November 1, 2016: New Phytologist
https://www.readbyqxmd.com/read/27796996/serum-adipocyte-fatty-acid-binding-protein-fabp4-levels-in-women-from-mexico-exposed-to-polycyclic-aromatic-hydrocarbons-pahs
#18
Ángeles C Ochoa-Martínez, Tania Ruíz-Vera, Lucia G Pruneda-Álvarez, Ana K González-Palomo, Claudia I Almendarez-Reyna, Francisco J Pérez-Vázquez, Iván N Pérez-Maldonado
Recent studies indicate that exposure to polycyclic aromatic hydrocarbons (PAHs) is a very important risk factor for the development of cardiovascular diseases (CVDs). Correspondingly, adipocyte-fatty acid binding protein (FABP4, also known as aP2 and AFABP) has been proposed as a new, meaningful and useful biomarker to predict metabolic and cardiovascular diseases. Therefore, the aim of this study was to evaluate serum FABP4 levels in Mexican women exposed to PAHs. Urinary 1-hydroxypyrene ((1-OHP), exposure biomarker for PAHs) levels were quantified using a high-performance liquid chromatography (HPLC) technique, and serum FABP4 concentrations were analyzed using a commercially available ELISA kit...
October 31, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27795298/fabp4-ap2-regulates-macrophage-redox-signaling-and-inflammasome-activation-via-control-of-ucp2
#19
Kaylee A Steen, Hongliang Xu, David A Bernlohr
Obesity-linked metabolic disease is mechanistically associated with the accumulation of proinflammatory macrophages in adipose tissue leading to increased reactive oxygen species (ROS) production and low-grade, chronic inflammation. Previous work has demonstrated that deletion of the adipocyte fatty acid-binding protein (FABP4/aP2) uncouples obesity from inflammation via up-regulation of the uncoupling protein 2 (UCP2). Herein we demonstrate that ablation of FABP4/aP2 regulates systemic redox capacity, reduces cellular protein sulfhydryl oxidation and in particular, oxidation of mitochondrial protein cysteine residues...
October 17, 2016: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27773669/cytokinin-response-factors-gating-environmental-signals-and-hormones
#20
Jungmook Kim
CYTOKININ RESPONSE FACTORs (CRFs) encode transcription factors belonging to a small family within the APETALA2/ETHYLENE RESPONSIVE FACTOR (AP2/ERF) superfamily. Recent studies have revealed the biological functions of some arabidopsis CRFs, providing insight into the role of these plant transcription factors in integrating environmental and hormonal signals for plant adaptation.
December 2016: Trends in Plant Science
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