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Choanal atresia mitomycin

Said Anajar, Jawad Hassnaoui, Sami Rouadi, Reda Abada, Mohammed Roubal, Mohammed Mahtar
INTRODUCTION: Adult choanal atresia is a rare congenital malformation of the nasal cavity characterized by the complete obliteration of the posterior choanae, only ninth cases are reported in the literature, we present in our observation the tenth case of adult bilateral choanal atresia. PRESENTATION OF CASE: A 18-year-old man presented at our department with complaints of nasal obstruction, nasal discharge, snoring, anosmia, and mouth breathing since childhood...
2017: International Journal of Surgery Case Reports
Apostolos Karligkiotis, Paolo Farneti, Stefania Gallo, Alessandro Pusateri, Francesco Zappoli-Thyrion, Vittorio Sciarretta, Fabio Pagella, Paolo Castelnuovo, Ernesto Pasquini
OBJECTIVE: The purposes of this study were to report our experience with endoscopic treatment of choanal atresia (CA), to illustrate our surgical technique and analyse the different factors that may affect outcomes. MATERIAL AND METHODS: A retrospective review was performed of patients affected by congenital CA and treated between June 1996 and November 2013 at three referral centres which follow a uniform policy. RESULTS: Eighty-four patients with CA (55 unilateral and 29 bilateral), aged between one day and 76 years (mean, 13 years) were included...
June 2017: Journal of Cranio-maxillo-facial Surgery
Julie E Strychowsky, Kosuke Kawai, Ethan Moritz, Reza Rahbar, Eelam A Adil
OBJECTIVES: The use of nasal stents as a postoperative adjunct following repair of choanal atresia remains controversial. The study objective was to systematically review the literature regarding the efficacy and safety of stenting following transnasal endoscopic repair of bilateral choanal atresia. STUDY DESIGN: Systematic review with meta-analysis. METHODS: A comprehensive search in PubMed, EMBASE, CINAHL, and the Cochrane Library was conducted...
January 2016: Laryngoscope
Mona Gangar, John P Bent
PURPOSE OF REVIEW: To describe the efficacy of mitomycin C in combating airway stenosis. RECENT FINDINGS: Recent publications discussing mitomycin C utility have not altered the mixed results previously established by prospective trials. SUMMARY: Mitomycin C has been used for the past 16 years to inhibit pediatric airway fibroblast proliferation. Its benefit remains more hypothetical than proven and its future role remains uncertain.
December 2014: Current Opinion in Otolaryngology & Head and Neck Surgery
John M Carter, Claire Lawlor, J Lindhe Guarisco
OBJECTIVE: To determine the efficacy of topical mitomycin and stenting in patients that have undergone endoscopic repair of choanal atresia. METHODS: Retrospective review of 37 endoscopic operations on pediatric patients for choanal atresia. RESULTS: Twenty-six sides were operated on in 17 patients; 37 total operations were performed. All 17 patients were repaired endoscopically with 1 patient requiring transpalatal revision surgery. Eight patients (47%) had a unilateral atresia and 9 (53%) were bilateral...
February 2014: International Journal of Pediatric Otorhinolaryngology
Bin Xie, Min Yin, Xinjie Zhu, Ziping Lin
OBJECTIVE: To explore the feasibility and efficacy of mitomycin C(MMC) in the treatment of airway scarring stenosis. METHOD: The clinical materials of 11 patients with airway stenosis treated with MMC from 2008 to 2012 were analyzed retrospectively,including atresiaofnasopharynx/choanal atresia (2 cases), pharyngostenosis (1 case), and laryngotracheal stenosis (8 cases). All were treated with endoscopic surgery under general anesthe sia. Patients received topical application of MMC (0...
June 2013: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
M A Sattar, H I Hadi, R Homaira, T Sultana
This study was conducted to adopt better management technique for better outcome of bilateral congenital choanal atresia. Six consecutive neonates with bilateral congenital choanal atresia were included in this study. Emergency and elective management was done in various ways. Postoperative outcome was assessed clinically and endoscopically. Surgical management was done in two approaches. Three done in endoscopic transnasal approach and another 3 in transpalatine approach. Patient with endoscopic approach recovered earlier with minimum morbidity...
January 2013: Mymensingh Medical Journal: MMJ
J Robert Newman, Paula Harmon, W Peyton Shirley, J Scott Hill, Audie L Woolley, Brian J Wiatrak
OBJECTIVE: To analyze factors affecting 15-year surgical outcomes of choanal atresia repair. DESIGN: Case series. SETTING: Tertiary care pediatric hospital. PATIENTS: Between April 17, 1996, and March 23, 2010, a total of 42 patients aged 3 days to 15 years underwent endoscopic or transpalatal choanal atresia repair by our pediatric otolaryngology faculty. MAIN OUTCOME MEASURES: Reoperation and restenosis rates, with consideration of effects of mitomycin C therapy, stenting, and postoperative dilation...
January 2013: JAMA Otolaryngology—Head & Neck Surgery
Vincent Uzomefuna, Fergal Glynn, Basil Al-Omari, Stephen Hone, John Russell
INTRODUCTION/AIM: Choanal atresia (CA) is an obliteration, in newborns, of the airway at the level of posterior nasal aperture resulting in absence of connection between the nasal cavity and the aerodigestive tract. It is rare, with incidence of 1 in 7000 live births. This review is aimed at assessing the factors influencing the outcome of transnasal endoscopic repair of CA in a tertiary referral children's hospital. MATERIAL/METHOD: A retrospective study was carried out between 2002 and 2009...
May 2012: International Journal of Pediatric Otorhinolaryngology
Heejin Kim, Joo Hyun Park, Hyunchung Chung, Doo Hee Han, Dong-Young Kim, Chul Hee Lee, Chae-Seo Rhee
PURPOSE: Congenital choanal atresia (CCA) is a rare disease entity. The prevention of restenosis has been the main concerns of choanoplasty. The authors retrospectively analyzed patients with CCA to investigate clinical features and factors affecting surgical outcomes. MATERIAL/METHODS: Forty sides in 27 patients with CCA from 1987 through 2009 were reviewed with medical records that included symptoms, associated anomalies, laterality of atresia, types of the atretic plate, surgical approaches, uses of stent or mitomycin C, ages at operation, and surgical outcomes...
May 2012: American Journal of Otolaryngology
Mohamed Hassan, Tamer AboEl-Ezz, Tamer Youssef
BACKGROUND: A myriad of techniques have been described for managing posterior choanal atresia over the years, yet no standardized surgical protocol has been established. OBJECTIVE: To present our experience with the transoral-transnasal approach for repairing posterior choanal atresia. PATIENTS AND METHODS: A prospective study of children with posterior choanal atresia treated at Ain Shams University Hospitals from 2006 to 2010. Thirteen children affected by this malformation underwent a transoral-transnasal approach by the authors using a standardized surgical technique...
June 2011: Journal of Otolaryngology—Head & Neck Surgery
M K Bozkurt, B Keles, A Azimov, K Ozturk, H Arbag
OBJECTIVE: To evaluate the efficacy of topical mitomycin in providing the patency of the neochoanae in children undergoing transnasal endoscopic congenital choanal atresia (CA) repair. METHODS: A retrospective analysis of surgical results in CA patients who were treated in Selcuk University, Meram Medical Faculty, Department of Otolaryngology between November 2002 and November 2009 was performed. All patients underwent transnasal endoscopic approach using nasal telescopes and traditional sinus instrumentation together with a microdebrider...
July 2010: International Journal of Pediatric Otorhinolaryngology
Fadlullah Aksoy, Hasan Demirhan, Yavuz Selim Yildirim, Orhan Ozturan
BACKGROUND: A 23-year-old female patient presented to the outpatient clinic with bilateral nasal obstruction and discharge since birth. Endoscopic examination and paranasal sinus tomography revealed bilateral choanal atresia. She did not have any other congenital abnormalities. Her parents reported cyanosis in childhood that worsened during feeding and improved during crying; however, they had not visited a physician. She did not have remarkable complaints during early childhood or adolescence...
2009: Cases Journal
James D Ramsden, Paolo Campisi, Vito Forte
Congenital narrowing of the nasal airway at the posterior choanae, which can be uni- or bilateral, is an uncommon condition in pediatric patients. The surgical management of choanal atresia varies widely in different centers. This article discusses the different surgical strategies including: dilation and stenting; trans-palatal repair; and transnasal resection utilizing endoscopic sinus surgery (ESS) techniques. The merits of stents, lasers, CT-guided surgery, and the use of additional agents including mitomycin C are reviewed, as well as the particular problems associated with managing bilateral choanal atresia in neonates...
April 2009: Otolaryngologic Clinics of North America
Siew Ching Lee, Ing Ping Tang, Avatar Singh, S Selva Kumar, Shashinder Singh
Choanal stenosis has recently been recognized as a late complication of radiation therapy for nasopharyngeal carcinoma. The management of velopharyngeal stenosis is challenging with high risk of restenosis. We report a case of velopharyngeal stenosis post-radiotherapy and illustrated the use of mitomycin-C to prevent restenosis. Mitomycin-C application has being shown useful adjunct to surgical technique in managing nasopharyngeal stenosis for surgeons.
December 2009: Auris, Nasus, Larynx
Natacha Teissier, Florentia Kaguelidou, Vincent Couloigner, Martine François, Thierry Van Den Abbeele
OBJECTIVE: To analyze the different factors affecting the outcome of transnasal endoscopic repair of choanal atresia (CA) in children. DESIGN: Retrospective study. SETTING: Academic tertiary care children's hospital. PATIENTS: Eighty patients (48 girls and 32 boys) aged 3 days to 17 years (mean age, 3 years 8 months) who presented with unilateral (n = 53: 37 right, 16 left) or bilateral (n = 27) CA and underwent surgery between September 1996 and December 2005...
January 2008: Archives of Otolaryngology—Head & Neck Surgery
Ahmed Y Al-Ammar
OBJECTIVE: To investigate the effectiveness of topical mitomycin C (MMC) on outcome of endoscopic repair of choanal atresia (CA) in cases that had never had this operation and when nasal stent was not used. METHODS: Endoscopic repair of CA was performed in 20 children at King Abdul-Aziz University Hospital, Riyadh, Kingdom of Saudi Arabia between January 1999 and October 2005. Intra-operative application of topical MMC (0.4 mg/mL for 4 minutes) was carried out in 13 children, and 7 children did not receive MMC...
October 2007: Saudi Medical Journal
Jan Gosepath, Vilma E Santamaria, Burkard M Lippert, Wolf J Mann
This retrospective analysis reflects the outcome of various techniques used in a series of 41 cases of choanal atresia treated at the Department of Otoloaryngology, Head- and Neck Surgery at the University of Mainz between 1980 and 2006. Thirteen bilateral and 28 unilateral cases are included. After endonasal management in 38 and a transpalatine approach in 3 cases a total of 15 patients needed revision surgery between 1 and 5 times to establish a stable result. Postoperative stenting was used in 23 patients with a failure rate of 35%, whereas only 11% of the 18 patients without stenting had to be revised...
June 2007: Rhinology
Guillermina Pardo Romero, Tomás Mogollón Cano-Cortés, Jesús María Pando Pinto, Gabriel Trinidad Ruiz, Alicia González Palomino, Carlos Pantoja Hernández, Antonio Blasco Huelva
Choanal atresia is an infrequent congenital malformation. Classically, 4 surgical approaches have been described for its treatment: transnasal, transpalatal, trans-septal, and transantral. Of these, transpalatal was preferred. In recent years, the progress in nasal endoscopy has led to reconsideration of the transnasal route as being less invasive and providing excellent results. The use of stents to prevent re-stenosis is a controversial issue. However, the application of substances such as mitomycin may offer decreased need for stenting by reducing the development of cicatrix tissue...
January 2007: Acta Otorrinolaringológica Española
Frances M James, Eric J Parente, Jonathan E Palmer
CASE DESCRIPTION: A 1-day-old Standardbred foal with a history of extreme respiratory distress after birth consistent with upper airway obstruction was evaluated. A temporary tracheostomy tube was placed by the referring veterinarian. CLINICAL FINDINGS: On initial examination, there was evidence of hypoxic-ischemic syndrome, secondary to perinatal asphyxia. Endoscopy revealed obstruction of both nares at the level of the choanae; a diagnosis of bilateral choanal atresia was made...
December 1, 2006: Journal of the American Veterinary Medical Association
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