keyword
https://read.qxmd.com/read/38536958/assessing-the-interaction-effects-of-mitochondrial-dna-polymorphisms-and-lifestyle-on-heel-bone-mineral-density
#21
JOURNAL ARTICLE
Dan He, Huan Liu, Yijing Zhao, Wenming Wei, Qingqing Cai, Sirong Shi, Xiaoge Chu, Na Zhang, Xiaoyue Qin, Yumeng Jia, Yan Wen, Bolun Cheng, Feng Zhang
BACKGROUND: Bone mineral density (BMD) is a major predictor of osteoporotic fractures, and previous studies have reported the effects of mitochondrial dysfunction and lifestyle on BMD, respectively. However, their interaction effects on BMD are still unclear. Therefore, we aimed to investigate the possible interaction of mitochondrial DNA (mtDNA) and common lifestyles contributing to osteoporosis. METHODS: Our analysis included 119,120 white participants (Nfemale=65,949 and Nmale=53,171) from the UK Biobank with heel BMD phenotype data...
March 27, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38536640/genetically-predicted-apolipoprotein-e-levels-with-the-risk-of-panvascular-diseases-a-mendelian-randomization-study
#22
JOURNAL ARTICLE
Yi-Ming Shi, Dian Ou, Jia-Ting Li, Le Bao, Xiao-Dan Liu, Wei Zhang, Huang Ding
The aim of this study was to comprehensively assess the causal relationship between the overall genetic effect of circulating ApoE levels and panvascular lesions using newer genome-wide association data and two-sample bidirectional Mendelian randomization (MR) analysis. Two-way MR using single-nucleotide polymorphisms of circulating ApoE as instrumental variables was performed using the highest-priority Genome-wide association study (GWAS) data, with factor-adjusted and data-corrected statistics, to estimate causal associations between circulating ApoE levels and 10 pan-vascular diseases in > 500,000 UK Biobank participants, > 400,000 participants of Finnish ancestry, and numerous participants in a consortium of predominantly European ancestry...
March 27, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38536491/no-evidence-for-a-causal-contribution-of-bioavailable-testosterone-to-adhd-in-sex-combined-and-sex-specific-two-sample-mendelian-randomization-studies
#23
JOURNAL ARTICLE
Lars Dinkelbach, Triinu Peters, Corinna Grasemann, Johannes Hebebrand, Anke Hinney, Raphael Hirtz
The higher prevalence of attention-deficit/hyperactivity disorder (ADHD) in males raises the question of whether testosterone is implicated in ADHD risk. However, cross-sectional studies did not identify an association between ADHD and testosterone levels. Mendelian randomization (MR) studies can overcome limitations inherent to association studies, especially of reverse causation and residual confounding. In the current study, sex-combined and sex-specific two-sample MR analyses were conducted to address whether testosterone has a causal influence on ADHD risk...
March 27, 2024: European Child & Adolescent Psychiatry
https://read.qxmd.com/read/38536179/genetic-and-phenotypic-features-of-schizophrenia-in-the-uk-biobank
#24
JOURNAL ARTICLE
Sophie E Legge, Antonio F Pardiñas, Grace Woolway, Elliott Rees, Alastair G Cardno, Valentina Escott-Price, Peter Holmans, George Kirov, Michael J Owen, Michael C O'Donovan, James T R Walters
IMPORTANCE: Large-scale biobanks provide important opportunities for mental health research, but selection biases raise questions regarding the comparability of individuals with those in clinical research settings. OBJECTIVE: To compare the genetic liability to psychiatric disorders in individuals with schizophrenia in the UK Biobank with individuals in the Psychiatric Genomics Consortium (PGC) and to compare genetic liability and phenotypic features with participants recruited from clinical settings...
March 27, 2024: JAMA Psychiatry
https://read.qxmd.com/read/38536116/regular-use-of-aspirin-and-statins-reduces-the-risk-of-cancer-in-individuals-with-systemic-inflammatory-diseases
#25
JOURNAL ARTICLE
Jia-Run Lin, Duan-Duan Han, Wei Wei, Qin Zeng, Zi-Xuan Rong, Xue Bai, Yan-Pei Zhang, Jian Wang, Xiao-Ting Cai, Xu-Guang Rao, Si-Cong Ma, Zhong-Yi Dong
Aspirin has shown potential for cancer prevention, but a recent large randomized controlled trial found no evidence for a reduction in cancer risk. Given the anti-inflammatory effects of aspirin, systemic inflammatory diseases (SIDs), such as osteoporosis, cardiovascular diseases, and metabolic diseases, could potentially modify the aspirin-cancer link. To investigate the impact of aspirin in people with SIDs, we conducted an observational study on a prospective cohort of 478,615 UK Biobank participants. Individuals with at least one of the 41 SIDs displayed a higher cancer risk than those without SIDs...
March 27, 2024: Cancer Research
https://read.qxmd.com/read/38535961/investigation-of-the-association-between-air-pollution-and-non-alcoholic-fatty-liver-disease-in-the-european-population-a-mendelian-randomization-study
#26
JOURNAL ARTICLE
Jing Yang, Yaqi Zhang, Yin Yuan, Zhongyang Xie, Lanjuan Li
Non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent chronic liver disease worldwide. At the same time, the relationship between air pollution and the likelihood of developing NAFLD has been a subject of debate due to conflicting findings in previous observational research. Our objective was to examine the potential correlation between air pollutant levels and the risk of NAFLD in the European population by employing a two-sample Mendelian randomization (MR) analysis. The UK Biobank Consortium provided the summary statistics for various air pollution indicators (PM2...
March 21, 2024: Toxics
https://read.qxmd.com/read/38534495/mendelian-randomisation-analysis-of-causal-association-between-lifestyle-health-factors-and-keratoconus
#27
JOURNAL ARTICLE
Jiaxuan Cheng, Lanting Yang, Yishan Ye, Lvfu He, Shihao Chen, Junjie Wang
Keratoconus (KC), a leading cause of vision impairment, has an unclear aetiology. This study used Mendelian randomization (MR) to explore the causal links between various factors (smoking, asthma, Down syndrome, inflammatory bowel disease, atopic dermatitis, and serum 25-hydroxyvitamin D levels) and KC. A two-sample MR design, grounded in genome-wide association study (GWAS) summary statistics, was adopted using data from FinnGen, UK Biobank, and other GWAS-related articles. The inverse-variance weighted (IVW) method was employed, complemented by the Wald ratio method for factors with only one single-nucleotide polymorphism (SNP)...
February 26, 2024: Bioengineering
https://read.qxmd.com/read/38533647/physical-activity-mental-activity-and-risk-of-incident-stroke-a-prospective-cohort-study
#28
JOURNAL ARTICLE
Zhi Cao, Jing Zhang, Zuolin Lu, Han Chen, Jiahao Min, Yabing Hou, Xiaohe Wang, Chenjie Xu
BACKGROUND: Cumulative evidence suggests a correlation between physical or mental activity and the risk of stroke. However, the combined impact of these activities on stroke onset remains unexplored. This study identified physical and mental activity patterns using principal component analysis and investigated their associations with risk of incident stroke in the general population. METHODS: Our study was sourced from the UK Biobank cohort between 2006 and 2010...
March 27, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38533550/correction-to-in-people-with-type-2-diabetes-sarcopenia-is-associated-with-the-incidence-of-cardiovascular-disease-a-prospective-cohort-study-from-the-uk-biobank
#29
(no author information available yet)
No abstract text is available yet for this article.
March 27, 2024: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/38533417/causal-relationship-between-telomere-length-and-risk-of-intracranial-aneurysm-a-bidirectional-mendelian-randomization-study
#30
JOURNAL ARTICLE
Bangjie Xu, Jiangbin Ren, Siqi Zhu, Yu Ding, Wei Zhou, Qing Guo, Yan Fang, Jing Zheng
BACKGROUND: Telomere length is closely linked to the aging phenotype, where cellular aging results in the production of a cascade of cell factors and the senescence-associated secretory phenotype (SASP), leading to an inflammatory response. The presence of inflammation plays a crucial role in the formation of intracranial aneurysms. Nevertheless, the relationship between telomere length and intracranial aneurysms remains unclear. This study aims to explore the causal connection between telomere length and intracranial aneurysms through the utilization of Mendelian randomization (MR) analysis...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38533128/health-data-sharing-attitudes-towards-primary-and-secondary-use-of-data-a-systematic-review
#31
JOURNAL ARTICLE
Fidelia Cascini, Ana Pantovic, Yazan A Al-Ajlouni, Valeria Puleo, Lucia De Maio, Walter Ricciardi
BACKGROUND: To receive the best care, people share their health data (HD) with their health practitioners (known as sharing HD for primary purposes). However, during the past two decades, sharing for other (i.e., secondary) purposes has become of great importance in numerous fields, including public health, personalized medicine, research, and development. We aimed to conduct the first comprehensive overview of all studies that investigated people's HD sharing attitudes-along with associated barriers/motivators and significant influencing factors-for all data types and across both primary and secondary uses...
May 2024: EClinicalMedicine
https://read.qxmd.com/read/38532472/association-between-genetic-risk-and-adherence-to-healthy-lifestyle-for-developing-age-related-hearing-loss
#32
JOURNAL ARTICLE
Sang-Hyuk Jung, Young Chan Lee, Manu Shivakumar, Jaeyoung Kim, Jae-Seung Yun, Woong-Yang Park, Hong-Hee Won, Dokyoon Kim
BACKGROUND: Previous studies have shown that lifestyle/environmental factors could accelerate the development of age-related hearing loss (ARHL). However, there has not yet been a study investigating the joint association among genetics, lifestyle/environmental factors, and adherence to healthy lifestyle for risk of ARHL. We aimed to assess the association between ARHL genetic variants, lifestyle/environmental factors, and adherence to healthy lifestyle as pertains to risk of ARHL. METHODS: This case-control study included 376,464 European individuals aged 40 to 69 years, enrolled between 2006 and 2010 in the UK Biobank (UKBB)...
March 26, 2024: BMC Medicine
https://read.qxmd.com/read/38532314/reproductive-factors-and-risk-of-lung-cancer-among-300-000-chinese-female-never-smokers-evidence-from-the-china-kadoorie-biobank-study
#33
JOURNAL ARTICLE
Marwa M A Elbasheer, Bastian Bohrmann, Yiping Chen, Jun Lv, Dianjianyi Sun, Xia Wu, Xiaoming Yang, Daniel Avery, Liming Li, Zhengming Chen, Christiana Kartsonaki, Ka Hung Chan, Ling Yang
BACKGROUND: Lung cancer is the leading cause of cancer mortality among Chinese females despite the low smoking prevalence among this population. This study assessed the roles of reproductive factors in lung cancer development among Chinese female never-smokers. METHODS: The prospective China Kadoorie Biobank (CKB) recruited over 0.5 million Chinese adults (0.3 million females) from 10 geographical areas in China in 2004-2008 when information on socio-demographic/lifestyle/environmental factors, physical measurements, medical history, and reproductive history collected through interviewer-administered questionnaires...
March 26, 2024: BMC Cancer
https://read.qxmd.com/read/38532309/contribution-of-nutritional-lifestyle-and-metabolic-risk-factors-to-parkinson-s-disease
#34
JOURNAL ARTICLE
Nicola Veronese, Andrea Nova, Teresa Fazia, Emilia Riggi, Lin Yang, Laura Piccio, Bo-Huei Huang, Matthew Ahmadi, Mario Barbagallo, Maria Notarnicola, Gianluigi Giannelli, Giovanni De Pergola, Emmanuel Stamatakis, Emanuele Cereda, Luisa Bernardinelli, Luigi Fontana
BACKGROUND: Modifiable risk factors for Parkinson's disease (PD) are poorly known. OBJECTIVES: The aim is to evaluate independent associations of different nutritional components, physical activity, and sedentary behavior and metabolic factors with the risk of PD. METHODS: In this population-based prospective cohort study using the data of the United Kingdom Biobank (from 2006-2010), 502,017 men and women who were free from PD (International Classification of Diseases 10th edition; "G20") at baseline were included...
March 26, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38531894/abundant-pleiotropy-across-neuroimaging-modalities-identified-through-a-multivariate-genome-wide-association-study
#35
JOURNAL ARTICLE
E P Tissink, A A Shadrin, D van der Meer, N Parker, G Hindley, D Roelfs, O Frei, C C Fan, M Nagel, T Nærland, M Budisteanu, S Djurovic, L T Westlye, M P van den Heuvel, D Posthuma, T Kaufmann, A M Dale, O A Andreassen
Genetic pleiotropy is abundant across spatially distributed brain characteristics derived from one neuroimaging modality (e.g. structural, functional or diffusion magnetic resonance imaging [MRI]). A better understanding of pleiotropy across modalities could inform us on the integration of brain function, micro- and macrostructure. Here we show extensive genetic overlap across neuroimaging modalities at a locus and gene level in the UK Biobank (N = 34,029) and ABCD Study (N = 8607)...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38531849/an-analysis-of-the-accuracy-of-retrospective-birth-location-recall-using-sibling-data
#36
JOURNAL ARTICLE
Stephanie von Hinke, Nicolai Vitt
Many surveys ask participants to retrospectively record their location of birth. This paper examines the accuracy of such data in the UK Biobank using a sample of full siblings. Comparison of reported birth locations for siblings with different age gaps allows us to estimate the probabilities of household moves and of misreported birth locations. Our first contribution is to show that there are inaccuracies in retrospective birth location data, showing a sizeable probability of misreporting, with 28% of birth coordinates, 16% of local districts and 6% of counties of birth being incorrectly reported...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38531670/heart-rate-variability-analysis-in-obstructive-sleep-apnoea-patients-with-daytime-sleepiness
#37
JOURNAL ARTICLE
Seren Ucak, Hasthi U Dissanayake, Philip de Chazal, Yu Sun Bin, Kate Sutherland, Bianca Setionago, Benjamin Tong, Brendon J Yee, Kristina Kairaitis, John R Wheatley, Amanda J Piper, Peter A Cistulli
STUDY OBJECTIVES: Recent studies suggest sleepy patients with OSA are at higher risk for incident cardiovascular disease. This study assessed cardiac autonomic function in sleepy versus non-sleepy patients with obstructive sleep apnoea (OSA) using heart rate variability (HRV) analysis. We hypothesised that HRV profiles of sleepy patients would indicate higher cardiovascular risk. METHODS: Electrocardiograms (ECG) derived from polysomnograms (PSG) collected by the Sydney Sleep Biobank were used to study HRV in groups of sleepy (ESS≥10) and non-sleepy OSA patients (ESS<10)...
March 26, 2024: Sleep
https://read.qxmd.com/read/38531250/extensive-t1-weighted-mri-preprocessing-improves-generalizability-of-deep-brain-age-prediction-models
#38
JOURNAL ARTICLE
Lara Dular, Franjo Pernuš, Žiga Špiclin
Brain age is an estimate of chronological age obtained from T1-weighted magnetic resonance images (T1w MRI), representing a straightforward diagnostic biomarker of brain aging and associated diseases. While the current best accuracy of brain age predictions on T1w MRIs of healthy subjects ranges from two to three years, comparing results across studies is challenging due to differences in the datasets, T1w preprocessing pipelines, and evaluation protocols used. This paper investigates the impact of T1w image preprocessing on the performance of four deep learning brain age models from recent literature...
March 20, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38530864/associations-between-onset-age-of-orthostatic-hypotension-and-incident-myocardial-infarction-stroke-and-dementia-a-prospective-cohort-study
#39
JOURNAL ARTICLE
Jie Liang, Wenya Zhang, Yang Pan, Darui Gao, Yongqian Wang, Wuxiang Xie, Fanfan Zheng
BACKGROUND: The associations of age at orthostatic hypotension onset with incident myocardial infarction (MI), stroke, and dementia remain unknown. This study aimed to examine whether younger onset age of orthostatic hypotension was associated with higher risks of incident MI, stroke, and dementia. METHODS: Data were obtained from the UK Biobank. Information on the diagnosis of orthostatic hypotension, MI, stroke, and dementia was collected at baseline (2006-2010) and follow-ups (median=13 years)...
March 26, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38530472/differences-in-branched-chain-amino-acid-to-tyrosine-ratio-btr-among-etiologies-of-chronic-liver-disease-progression-compared-to-healthy-adults
#40
JOURNAL ARTICLE
Masaaki Mino, Akitoshi Sano, Eiji Kakazu, Hiroko Matsubara, Keisuke Kakisaka, Takayuki Kogure, Katsunori Sekine, Yoshihiko Aoki, Masatoshi Imamura, Michitaka Matsuda, Taiji Yamazoe, Taizo Mori, Sachiyo Yoshio, Jun Inoue, Atsushi Masamune, Tatsuya Kanto
BACKGROUND: The branched-chain amino acids (BCAAs) to tyrosine (Tyr) ratio (BTR) test is used to evaluate the progression of chronic liver disease (CLD). However, the differences across sex, age, body mass index (BMI) and etiologies are still unclear. METHODS: We retrospectively reviewed data from 2,529 CLD cases with free amino acids (FAAs) in peripheral blood from four hospitals and 16,421 general adults with FAAs data from a biobank database. In total, 1,326 patients with CLD (covering seven etiologies) and 8,086 healthy controls (HCs) were analyzed after exclusion criteria...
March 26, 2024: Journal of Gastroenterology
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