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https://www.readbyqxmd.com/read/29330544/perceptions-of-legislation-relating-to-the-sharing-of-genomic-biobank-results-with-donors-a-survey-of-bbmri-eric-biobanks
#1
Minna Brunfeldt, Harriet Teare, Sirpa Soini, Helena Kääriäinen
Biobanks accumulate huge amounts of research findings, including participants' genomic data. Increasingly this leads to biobanks receiving research results that could be of clinical significance to biobank participants. The EU Horizon 2020 Project 'Genetics Clinic of the Future' surveyed European biobanks' perceptions of the legal and regulatory requirements for communicating individual research results to donors. The goal was to gain background knowledge for possible future guidelines, especially relating to the consent process...
January 12, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29329063/seasonality-of-depressive-symptoms-in-women-but-not-in-men-a-cross-sectional-study-in-the-uk-biobank-cohort
#2
Laura M Lyall, Cathy A Wyse, Carlos A Celis-Morales, Donald M Lyall, Breda Cullen, Daniel Mackay, Joey Ward, Nicholas Graham, Rona J Strawbridge, Jason M R Gill, Amy Ferguson, Mark E S Bailey, Jill P Pell, Annie M Curtis, Daniel J Smith
BACKGROUND: We examined whether seasonal variations in depressive symptoms occurred independently of demographic and lifestyle factors, and were related to change in day length and/or outdoor temperature. METHODS: In a cross-sectional analysis of >150,000 participants of the UK Biobank cohort, we used the cosinor method to assess evidence of seasonality of a total depressive symptoms score and of low mood, anhedonia, tenseness and tiredness scores in women and men...
January 4, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29325150/the-relationship-between-alcohol-use-and-long-term-cognitive-decline-in-middle-and-late-life-a-longitudinal-analysis-using-uk-biobank
#3
Giovanni Piumatti, Simon C Moore, Damon M Berridge, Chinmoy Sarkar, John Gallacher
Background: Using UK Biobank data, this study sought to explain the causal relationship between alcohol intake and cognitive decline in middle and older aged populations. Methods: Data from 13 342 men and women, aged between 40 and 73 years were used in regression analysis that tested the functional relationship and impact of alcohol on cognitive performance. Performance was measured using mean reaction time (RT) and intra-individual variation (IIV) in RT, collected in response to a perceptual matching task...
January 9, 2018: Journal of Public Health
https://www.readbyqxmd.com/read/29324546/applying-precision-medicine-to-ovarian-cancer-proof-of-principle-for-a-molecular-second-look
#4
Melissa Schwartz, Olga Camacho-Vanegas, Ashley M Wood, Matthew Dashkoff, Courtney Whitelock, Timothy T Harkins, Carmel J Cohen, Ann Marie Beddoe, Peter Dottino, John A Martignetti
OBJECTIVES: The objectives of this study were to assess if targeted investigation for tumor-specific mutations by ultradeep DNA sequencing of peritoneal washes of ovarian cancer patients after primary surgical debulking and chemotherapy, and clinically diagnosed as disease free, provides a more sensitive and specific method to assess actual treatment response and tailor future therapy and to compare this "molecular second look" with conventional cytology and histopathology-based findings...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29321476/sample-handling-of-gastric-tissue-and-o-glycan-alterations-in-paired-gastric-cancer-and-non-tumorigenic-tissues
#5
Barbara Adamczyk, Chunsheng Jin, Karol Polom, Pedro Muñoz, Miguel A Rojas-Macias, David Zeeberg, Mats Borén, Franco Roviello, Niclas G Karlsson
Sample collection, handling and storage are the most critical steps for ensuring the highest preservation of specimens. Pre-analytical variability can influence the results as protein signatures alter rapidly after tissue excision or during long-term storage. Hence, we evaluated current state-of-the-art biobank preservation methods from a glycomics perspective and analyzed O-glycan alterations occurring in the gastric cancer tissues. Paired tumor and adjacent normal tissue samples were obtained from six patients undergoing gastric cancer surgery...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317602/genome-wide-meta-analyses-of-stratified-depression-in-generation-scotland-and-uk-biobank
#6
Lynsey S Hall, Mark J Adams, Aleix Arnau-Soler, Toni-Kim Clarke, David M Howard, Yanni Zeng, Gail Davies, Saskia P Hagenaars, Ana Maria Fernandez-Pujals, Jude Gibson, Eleanor M Wigmore, Thibaud S Boutin, Caroline Hayward, Generation Scotland, David J Porteous, Ian J Deary, Pippa A Thomson, Chris S Haley, Andrew M McIntosh
Few replicable genetic associations for Major Depressive Disorder (MDD) have been identified. Recent studies of MDD have identified common risk variants by using a broader phenotype definition in very large samples, or by reducing phenotypic and ancestral heterogeneity. We sought to ascertain whether it is more informative to maximize the sample size using data from all available cases and controls, or to use a sex or recurrent stratified subset of affected individuals. To test this, we compared heritability estimates, genetic correlation with other traits, variance explained by MDD polygenic score, and variants identified by genome-wide meta-analysis for broad and narrow MDD classifications in two large British cohorts - Generation Scotland and UK Biobank...
January 10, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29314248/calcium-and-vitamin-d-supplementation-are-not-associated-with-risk-of-incident-ischaemic-cardiac-events-or-death-findings-from-the-uk-biobank-cohort
#7
Nicholas C Harvey, Stefania D'Angelo, Julien Paccou, Elizabeth M Curtis, Mark Edwards, Zahra Raisi-Estabragh, Karen Walker-Bone, Steffen E Petersen, Cyrus Cooper
We investigated associations between calcium/vitamin D supplementation and incident cardiovascular events/deaths in a UK population-based cohort. UK Biobank is a large prospective cohort comprising 502,637 men and women aged 40-69 years at recruitment. Supplementation with calcium/vitamin D was self-reported, and information on incident hospital admission (ICD-10) for ischaemic heart disease (IHD), myocardial infarction (MI) any cardiovascular event, and subsequent death, was obtained from linkage to national registers...
January 4, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29310484/pathology-proteomics-and-the-pathway-to-personalised-medicine
#8
Ping Jin, Jiang Lan, Kui Wang, Mark S Baker, Canhua Huang, Edouard C Nice
As we move from a discovery to a translational phase in proteomics, with a focus on developing validated clinical assays to assist personalized medicine, there is a growing need for strong bidirectional interactions with the clinical pathology community. Thus, while on one hand the proteomics community will provide candidate biomarkers to assist in diagnosis, prognosis, surveillance, identification of individualized patient medication and development and validation of new assays for diagnostic use, on the other the pathology community will assist with specific tissue identification and selection (e...
January 8, 2018: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29309628/genome-wide-association-study-of-offspring-birth-weight-in-86-577-women-identifies-five-novel-loci-and-highlights-maternal-genetic-effects-that-are-independent-of-fetal-genetics
#9
Robin N Beaumont, Nicole M Warrington, Alana Cavadino, Jessica Tyrrell, Michael Nodzenski, Momoko Horikoshi, Frank Geller, Ronny Myhre, Rebecca C Richmond, Lavinia Paternoster, Jonathan P Bradfield, Eskil Kreiner-Møller, Ville Huikari, Sarah Metrustry, Kathryn L Lunetta, Jodie N Painter, Jouke-Jan Hottenga, Catherine Allard, Sheila J Barton, Ana Espinosa, Julie A Marsh, Catherine Potter, Ge Zhang, Wei Ang, Diane J Berry, Luigi Bouchard, Shikta Das, Hakon Hakonarson, Jani Heikkinen, Øyvind Helgeland, Berthold Hocher, Albert Hofman, Hazel M Inskip, Samuel E Jones, Manolis Kogevinas, Penelope A Lind, Letizia Marullo, Sarah E Medland, Anna Murray, Jeffrey C Murray, Pål R Njølstad, Ellen A Nohr, Christoph Reichetzeder, Susan M Ring, Katherine S Ruth, Loreto Santa-Marina, Denise M Scholtens, Sylvain Sebert, Verena Sengpiel, Marcus A Tuke, Marc Vaudel, Michael N Weedon, Gonneke Willemsen, Andrew R Wood, Hanieh Yaghootkar, Louis J Muglia, Meike Bartels, Caroline L Relton, Craig E Pennell, Leda Chatzi, Xavier Estivill, John W Holloway, Dorret I Boomsma, Grant W Montgomery, Joanne M Murabito, Tim D Spector, Christine Power, Marjo-Ritta Järvelin, Hans Bisgaard, Struan Fa Grant, Thorkild Ia Sørensen, Vincent W Jaddoe, Bo Jacobsson, Mads Melbye, Mark I McCarthy, Andrew T Hattersley, M Geoffrey Hayes, Timothy M Frayling, Marie-France Hivert, Janine F Felix, Elina Hyppönen, William L Lowe, David M Evans, Debbie A Lawlor, Bjarke Feenstra, Rachel M Freathy
Genome-wide association studies (GWAS) of birth weight have focused on fetal genetics, while relatively little is known about the role of maternal genetic variation. We aimed to identify maternal genetic variants associated with birth weight that could highlight potentially relevant maternal determinants of fetal growth. We meta-analysed data on up to 8.7 million SNPs in up to 86,577 women of European descent from the Early Growth Genetics (EGG) Consortium and the UK Biobank. We used structural equation modelling (SEM) and analyses of mother-child pairs to quantify the separate maternal and fetal genetic effects...
January 3, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29307387/the-built-environment-and-obesity-in-uk-biobank-right-project-wrong-data
#10
Pablo Monsivais, Thomas Burgoine
No abstract text is available yet for this article.
January 2018: Lancet. Public Health
https://www.readbyqxmd.com/read/29307385/associations-between-fast-food-and-physical-activity-environments-and-adiposity-in-mid-life-cross-sectional-observational-evidence-from-uk-biobank
#11
Kate E Mason, Neil Pearce, Steven Cummins
BACKGROUND: The built environment might be associated with development of obesity and related disorders. We examined whether neighbourhood exposure to fast-food outlets and physical activity facilities were associated with adiposity in UK adults. METHODS: We used cross-sectional observational data from UK Biobank. Participants were aged 40-70 years and attended 21 assessment centres between 2006 and 2010. Using linked data on environments around each participant's residential address, we examined whether density of physical activity facilities and proximity to fast-food outlets were associated with waist circumference, body-mass index (BMI), and body fat percentage...
January 2018: Lancet. Public Health
https://www.readbyqxmd.com/read/29306691/sleep-behavior-and-depression-findings-from-the-china-kadoorie-biobank-of-0-5-million-chinese-adults
#12
Xiaoyan Sun, Bang Zheng, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Zhenwang Fu, Hong Guo, Peng Liang, Zhengming Chen, Junshi Chen, Canqing Yu, Liming Li
BACKGROUND: Mixed results have shown the association between sleep behavior and depression, but evidence relating the joint effect of sleep duration and sleep disturbances is limited, especially in Chinese population. METHODS: A total of 512,891 adults aged 30-79 years from China Kadoorie Biobank (CKB) were included. Depression was defined by Composite International Diagnostic Inventory-short form (CIDI-SF). Sleep duration and sleep disturbances, including difficulty initiating and maintaining sleep (DIMS), early morning awakening (EMA), daytime dysfunction (DDF) and any sleep disturbances (ASD), were obtained by a self-reported questionnaire...
December 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29305721/paragangliomas-arise-through-an-autonomous-vasculo-angio-neurogenic-program-inhibited-by-imatinib
#13
Fabio Verginelli, Silvia Perconti, Simone Vespa, Francesca Schiavi, Sampath Chandra Prasat, Paola Lanuti, Alessandro Cama, Lorenzo Tramontana, Diana Liberata Esposito, Simone Guarnieri, Artenca Sheu, Mattia Russel Pantalone, Rosalba Florio, Annalisa Morgano, Cosmo Rossi, Giuseppina Bologna, Marco Marchisio, Andrea D'Argenio, Elisa Taschin, Rosa Visone, Giuseppe Opocher, Angelo Veronese, Carlo T Paties, Vinalogu K Rajasekhar, Cecilia Söderberg-Nauclér, Mario Sanna, Lavinia Vittoria Lotti, Renato Mariani-Costantini
Tumours can be viewed as aberrant tissues or organs sustained by tumorigenic stem-like cells that engage into dysregulated histo/organogenetic processes. Paragangliomas, prototypical organoid tumours constituted by dysmorphic variants of the vascular and neural tissues found in normal paraganglia, provide a model to test this hypothesis. To understand the origin of paragangliomas, we built a biobank comprising 77 cases, 18 primary cultures, 4 derived cell lines, 80 patient-derived xenografts and 11 cell-derived xenografts...
January 5, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/29305563/arterial-stiffness-association-with-chronic-inflammatory-disorders-in-the-uk-biobank-study
#14
Alex Dregan
OBJECTIVE: The present study tested the hypothesis that arterial stiffness will be elevated across overall and specific inflammatory disorders compared with an inflammation-free comparison group. METHODS: Adults (n=171 125) aged 40-70 years from the UK Biobank who were cardiovascular disease (CVD) free and who had their arterial stiffness assessed at the time of study recruitment between 2006 and 2010 were included. The main exposure was represented by a global measure of chronic inflammatory disorders...
January 4, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29305135/231st-enmc-international-workshop-international-standard-for-cidp-registry-and-biobank-naarden-the-netherlands-12-14-may-2017
#15
Filip Eftimov, Carina Bunschoten, Yusuf Rajabally, Luis Querol
No abstract text is available yet for this article.
December 5, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29304221/type-2-diabetes-and-risk-of-incident-cancers-in-china-a-prospective-study-among-0-5-million-chinese-adults
#16
Xiong-Fei Pan, Meian He, Canqing Yu, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Tangchun Wu, Zhengming Chen, An Pan, Liming Li
Using data from the China Kadoorie Biobank study, we conducted a prospective investigation on the association between type 2 diabetes mellitus (T2DM) and cancer risk in Chinese adults. A total of 508,892 participants (mean (standard deviation) age = 51.5 (10.7) years) without prior cancer diagnosis at baseline (2004-2008) were included. We documented 17,463 incident cancer cases during follow-up until December 31, 2013. Participants with T2DM had increased risks of total and certain site-specific cancers, and the hazard ratio (HR) was 1...
January 3, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29298802/associations-of-general-and-central-adiposity-with-incident-diabetes-in-chinese-men-and-women
#17
Fiona Bragg, Kun Tang, Yu Guo, Andri Iona, Huaidong Du, Michael V Holmes, Zheng Bian, Christiana Kartsonaki, Yiping Chen, Ling Yang, Qiang Sun, Caixia Dong, Junshi Chen, Rory Collins, Richard Peto, Liming Li, Zhengming Chen
OBJECTIVE: We assess associations of general and central adiposity in middle age and of young adulthood adiposity with incident diabetes in adult Chinese and estimate the associated population burden of diabetes. RESEARCH DESIGN AND METHODS: The prospective China Kadoorie Biobank enrolled 512,891 adults 30-79 years of age from 10 localities across China during 2004-2008. During 9.2 years of follow-up, 13,416 cases of diabetes were recorded among 482,589 participants without diabetes at baseline...
January 3, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29295838/genetic-evidence-that-carbohydrate-stimulated-insulin-secretion-leads-to-obesity
#18
Christina M Astley, Jennifer N Todd, Rany M Salem, Sailaja Vedantam, Cara B Ebbeling, Paul L Huang, David S Ludwig, Joel N Hirschhorn, Jose C Florez
BACKGROUND: A fundamental precept of the carbohydrate-insulin model of obesity is that insulin secretion drives weight gain. However, fasting hyperinsulinemia can also be driven by obesity-induced insulin resistance. We used genetic variation to isolate and estimate the potentially causal effect of insulin secretion on body weight. METHODS: Genetic instruments of variation of insulin secretion [assessed as insulin concentration 30 min after oral glucose (insulin-30)] were used to estimate the causal relationship between increased insulin secretion and body mass index (BMI), using bidirectional Mendelian randomization analysis of genome-wide association studies...
January 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29294590/-association-between-body-weight-change-during-early-and-middle-adulthood-and-the-risk-of-type-2-diabetes-in-middle-aged-and-elderly-population
#19
Q Hu, C Q Jiang, W S Zhang, J J Cheng, L Xu, Y L Jin, Z M Shen, F Zhu, D Q Lam
Objective: To examine the association between weight changes during early and middle adulthood and the risk of type 2 diabetes mellitus in middle aged and elderly population. Methods: Based on the Guangzhou Biobank Cohort Study (GBCS), 28 736 residents aged ≥50 years were included in Guangzhou. Multivariate logistic regression was used to analyze the association between body weight changes during early or middle adulthood and age when the heaviest weight reaching the threshold on the risk of type 2 diabetes mellitus in middle age or elderly population...
December 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29291495/prenatal-and-early-postnatal-stress-and-later-life-inflammation
#20
Jolene Masters Pedersen, Erik Lykke Mortensen, Dinne Skjærlund Christensen, Maarten Rozing, Helle Brunsgaard, Rikke Hodal Meincke, Gitte Lindved Petersen, Rikke Lund
BACKGROUND: Evidence suggests that maternal psychological and social stress during the prenatal period and in childhood represent an important condition that may adversely impact the anatomy and physiology of the developing child with implications for a number of health-related conditions and disorders. In a large prospective study, we aim to address if social stressors in the prenatal and early postnatal periods, as individual exposures as well as their accumulation, are associated with a range of inflammatory markers in late middle-aged offspring...
December 21, 2017: Psychoneuroendocrinology
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