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Amantadine

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https://www.readbyqxmd.com/read/29670072/a-highly-selective-and-strong-anti-interference-host-guest-complex-as-fluorescent-probe-for-detection-of-amantadine-by-indicator-displacement-assay
#1
Linzhao Zhu, Zhiyong Zhao, Xiongzhi Zhang, Haijun Zhang, Feng Liang, Simin Liu
Amantadine (AMA) and its derivatives are illicit veterinary drugs that are hard to detect at very low concentrations. Developing a fast, simple and highly sensitive method for the detection of AMA is highly in demand. Here, we designed an anthracyclic compound (ABAM) that binds to a cucurbit[7]uril (CB[7]) host with a high association constant of up to 8.7 × 10⁸ M−1 . The host-guest complex was then used as a fluorescent probe for the detection of AMA. Competition by AMA for occupying the cavity of CB[7] allows ABAM to release from the CB[7]-ABAM complex, causing significant fluorescence quenching of ABAM (indicator displacement assay, IDA)...
April 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29662313/inhibition-of-h1n1-influenza-virus-induced-apoptosis-by-functionalized-selenium-nanoparticles-with-amantadine-through-ros-mediated-akt-signaling-pathways
#2
Yinghua Li, Zhengfang Lin, Min Guo, Mingqi Zhao, Yu Xia, Changbing Wang, Tiantian Xu, Bing Zhu
Introduction: As a therapeutic antiviral agent, the clinical application of amantadine (AM) is limited by the emergence of drug-resistant viruses. To overcome the drug-resistant viruses and meet the growing demand of clinical diagnosis, the use of biological nanoparticles (NPs) has increased in order to develop novel anti-influenza drugs. The antiviral activity of selenium NPs with low toxicity and excellent activities has attracted increasing attention for biomedical intervention in recent years...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29651527/simultaneous-determination-of-amantadine-and-rimantadine-in-feed-by-liquid-chromatography-qtrap-mass-spectrometry-with-information-dependent-acquisition
#3
Qi Jia, Dan Li, Xinlu Wang, Shuming Yang, Yongzhong Qian, Jing Qiu
A sensitive method for simultaneous determination of amantadine and rimantadine in feed was developed using an ultra-high-performance liquid chromatography-triple quadrupole linear ion trap mass spectrometry (UHPLC-Qtrap-MS) in the multiple reaction monitoring information-dependent acquisition-enhanced product ion (MRM-IDA-EPI) mode, and employing the mixed cation exchange (MCX) solid-phase extraction column as sample cleanup and amantadine-d15 and rimantadine-d4 as internal standards, respectively. Compared to traditional MRM mode, for the targeted drugs in feed simultaneously both the secondary mass spectra and MRM information can be obtained using UHPLC-Qtrap-MS with MRM-IDA-EPI mode, and thus more accurate qualitative confirmation results achieved even at lower concentration of 0...
April 13, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29622226/specific-colorimetric-elisa-method-based-on-dna-hybridization-reaction-and-non-crosslinking-gold-nanoparticles-aggregation-for-the-detection-of-amantadine
#4
Fang-Fei Zhu, Juan Peng, Zhen Huang, Li-Ming Hu, Gang-Gang Zhang, Dao-Feng Liu, Ke-Yu Xing, Kai-Yi Zhang, Wei-Hua Lai
Amantadine (AMD), a banned antiviral veterinary drug, is still being abused. This study developed a novel enzyme linked immunosorbent assay for the colorimetric detection of AMD involving DNA hybridization reaction and non-crosslinking gold nanoparticles (AuNPs) aggregation. Accordingly, the Primer 1-AuNPs-anti-AMD monoclonal antibody (mAb) could be captured by AMD artificial antigen on ELISA wells. Primer 2, which was complementary paired to Primer 1, was eventually added into the ELISA wells. After the hybridization reaction, the free Primer 2 in the supernatant was mixed with AuNPs and NaCl and induced a rapid color change of AuNPs...
August 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29607359/molecular-analysis-of-hemagglutinin-neuraminidase-matrix-genes-provide-insight-into-the-genetic-diversity-of-seasonal-h3n2-human-influenza-a-viruses-in-bangladesh-during-july-august-2012
#5
Mukesh Jain, Sohidul Islam, A S M Zisanur Rahman, Sharmin Akhtar, Kazi Nadim Hasan, Gias Uddin Ahsan, Abdul Khaleque, Maqsud Hossain
Influenza A virus subtype H3 is a threat to public health and it is important to understand the evolution of the viruses for the surveillance and the selection of vaccine strains. Comparative analysis of four Bangladeshi isolates with isolates circulating other parts of the world based on three candidate genes hemagglutinin (HA), neuraminidase (NA), matrix protein (MA) showed no evidence of significant distinct subclade of viruses circulating in the country over the period of study. Despite these findings, we found N161S substitution in all four H3N2 influenza stains resulting in the gain of NSS160-162 glycosylation site...
March 2018: Virusdisease
https://www.readbyqxmd.com/read/29578378/preparation-of-high-affinity-antibody-for-ribavirin-with-new-haptens-and-residue-analysis-in-chicken-muscle-eggs-and-duck-muscle
#6
Zhaopeng Wang, Xuezhi Yu, Licai Ma, Hebing Liu, Shuangyang Ding, Zhanhui Wang, Xiya Zhang, Jianzhong Shen, Kai Wen
In this work, high affinity polyclonal antibodies for ribavirin from new haptens were prepared and were used to analyze ribavirin residues in chicken muscle, eggs and duck muscle. The new haptens were synthesized with different spacers and the best antibody was obtained with an IC50 value as low as 0.61 ng/mL in indirect competitive enzyme-linked immunosorbent assay. The cross-reactivities with another 5 antiviral drugs including amantadine, rimantadine, moroxydine, zanamivir, and oseltamivir were less than 0...
March 26, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29570866/international-parkinson-and-movement-disorder-society-evidence-based-medicine-review-update-on-treatments-for-the-motor-symptoms-of-parkinson-s-disease
#7
REVIEW
Susan H Fox, Regina Katzenschlager, Shen-Yang Lim, Brandon Barton, Rob M A de Bie, Klaus Seppi, Miguel Coelho, Cristina Sampaio
OBJECTIVE: The objective of this review was to update evidence-based medicine recommendations for treating motor symptoms of Parkinson's disease (PD). BACKGROUND: The Movement Disorder Society Evidence-Based Medicine Committee recommendations for treatments of PD were first published in 2002 and updated in 2011, and we continued the review to December 31, 2016. METHODS: Level I studies of interventions for motor symptoms were reviewed. Criteria for inclusion and quality scoring were as previously reported...
March 23, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29564954/the-role-of-extended-release-amantadine-for-the-treatment-of-dyskinesia-in-parkinson-s-disease-patients
#8
Elkurd T Mazen, Laxman B Bahroo, Rajesh Pahwa
Levodopa is the most efficacious treatment for Parkinson's disease (PD). Long-term treatment with levodopa is limited due to dyskinesia. Dyskinesia in PD can be socially and functionally disabling. Extended-release amantadine (amantadine ER) is the first approved medication for the treatment of dyskinesia. When it is given at bedtime, it reaches plasma concentration approximately twice the level achieved by amantadine immediate release. Amantadine ER reduces the severity and duration of dyskinesia during the day, reduces OFF time and increases ON time without troublesome dyskinesia...
March 22, 2018: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/29550414/amantadine-induced-corneal-edema-in-a-pediatric-neuro-oncology-patient-a-case-report
#9
Maria Beran, Britta Okyere, Joshua Vova
No abstract text is available yet for this article.
March 14, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29532440/pooled-analyses-of-phase-iii-studies-of-ads-5102-amantadine-extended-release-capsules-for-dyskinesia-in-parkinson-s-disease
#10
Lawrence W Elmer, Jorge L Juncos, Carlos Singer, Daniel D Truong, Susan R Criswell, Sotirios Parashos, Larissa Felt, Reed Johnson, Rajiv Patni
BACKGROUND: Although levodopa is considered the most effective pharmacotherapy for motor symptoms of Parkinson's disease (PD), chronic use is associated with motor complications, including fluctuating response and unpredictable, involuntary movements called dyskinesia. ADS-5102 (amantadine) extended-release (ER) capsules (GOCOVRITM ) is a recent US FDA-approved treatment for dyskinesia in PD patients. ADS-5102 is a high-dose, ER formulation of amantadine, administered orally once daily at bedtime, that achieves high plasma drug concentrations throughout the day...
March 12, 2018: CNS Drugs
https://www.readbyqxmd.com/read/29530659/emergence-of-novel-reassortant-h6n2-avian-influenza-viruses-in-ducks-in-india
#11
Manoj Kumar, Shanmugasundaram Nagarajan, Harshad V Murugkar, Barnalee Saikia, Bharati Singh, Amit Mishra, Sushil K Tripathi, Sonam Agarwal, Shweta Shukla, Diwakar D Kulkarni, Vijendra Pal Singh, Chakradhar Tosh
H6 subtype avian influenza viruses (AIV), established in terrestrial poultry, have jumped species barriers and caused human infection indicating pandemic potential of the virus. Here, we report isolation, and antigenic and genetic characterization of two H6N2 viruses isolated from apparently healthy domestic ducks in Kerala and Assam, India during 2014 and 2015, respectively. Hemagglutination inhibition assay revealed antigenic divergence between the two isolates. This result was corroborated by amino acid differences at 55 positions (15...
March 9, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29519208/stimulant-use-in-the-management-of-mild-traumatic-brain-injury-a-qualitative-literature-review
#12
Mary Alexis Iaccarino, Lisa Liang Philpotts, Ross Zafonte, Joseph Biederman
OBJECTIVE: Mild traumatic brain injury (mTBI) often presents with cognitive complaints including difficulty with attention and concentration. As these symptoms resemble those of ADHD, stimulants may be a potential treatment for mTBI. This review evaluates the literature on the use of stimulants for the treatment of mTBI. METHOD: A systematic evaluation of the literature using six databases: Ovidmedline, Pubmed, psychINFO, CINAH, Embase, and Cochrane. Broad search terms were used and studies were included that evaluate the use of stimulant and stimulant-like medications in the mTBI population...
March 1, 2018: Journal of Attention Disorders
https://www.readbyqxmd.com/read/29518414/profiling-the-in-vitro-drug-resistance-mechanism-of-influenza-a-viruses-towards-the-am2-s31n-proton-channel-blockers
#13
Rami Musharrafieh, Chunlong Ma, Jun Wang
The majority of human influenza A viruses currently in circulation carry the amantadine-resistant AM2-S31N channel mutation. We previously discovered a series of AM2-S31N inhibitors with potent antiviral activity against both oseltamivir-sensitive and -resistant influenza A viruses. To understand the drug-resistance mechanism of AM2-S31N inhibitors, we performed serial viral passage experiments using the influenza virus A/California/07/2009 (H1N1) to select drug-resistant AM2 mutations against two representative AM2-S31N channel blockers (1 and 2)...
March 5, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29511826/efficacy-and-safety-of-amantadine-for-the-treatment-of-l-dopa-induced-dyskinesia
#14
REVIEW
Santiago Perez-Lloret, Olivier Rascol
L-DOPA induced dyskinesias (LIDs) may affect up to 40% of Parkinson's disease (PD) and impact negatively health-related quality of life. Amantadine has demonstrated significant antidyskinetic effects in animal PD models and in randomized double-blind placebo-controlled trials (RCTs) in patients with PD. These effects are thought to be related to the blockade of NMDA receptors modulating cortico-striatal glutamatergic-dopaminergic interactions involved in the genesis of LIDs. There are three pharmaceutical forms of amantadine currently available in the market: an oral immediate-release (IR) formulation, which is widely available; an extended-release (ER) formulation (ADS-5102) which has been recently developed and approved by the FDA; and an intravenous infusion (IV) solution, which is not commonly used in clinical practice...
March 7, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29510799/targeted-delivery-of-amantadine-loaded-methacrylate-nanosphere-ligands-for-the-potential-treatment-of-amyotrophic-lateral-sclerosis
#15
Zamanzima Mazibuko, Sunaina Indermun, Mershen Govender, Pradeep Kumar, Lisa C Du Toit, Yahya E Choonara, Girish Modi, Dinesh Naidoo, Viness Pillay
PURPOSE: This study aimed to develop and analyse poly(DL-lactic acid)-methacrylic acid nanospheres bound to the chelating ligand diethylenetriaminepentaacetic acid (DTPA)  for the targeted delivery of amantadine in Amyotrophic Lateral Sclerosis (ALS). METHODS: The nanospheres were prepared by a double emulsion solvent evaporation technique statistically optimized employing a 3-Factor Box-Behnken experimental design. Analysis of the particle size, zeta potential, polydispersity (Pdl), morphology, drug entrapment and drug release kinetics were carried out...
2018: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29502203/amantadine-attenuates-sepsis-induced-cognitive-dysfunction-possibly-not-through-inhibiting-toll-like-receptor-2
#16
Wei Xing, Pinjie Huang, Yang Lu, Weian Zeng, Zhiyi Zuo
Amantadine has been shown to reduce anesthesia and surgery-induced neuroinflammation and cognitive dysfunction. It is known that sepsis can impair brain function. We determined whether amantadine-attenuated sepsis-induced neuroinflammation and dysfunction of learning and memory and whether toll-like receptors (TLRs) play a role in the effects. Six- to eight-week-old mice were subjected to cecal ligation and puncture (CLP). Amantadine at 30 mg/kg/day was injected intraperitoneally for 3 days. CU-CPT22, a TLR1/TLR2 inhibitor, at 3 mg/kg/day was injected intraperitoneally for 2 days...
May 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29484607/treatment-of-tardive-dyskinesia-a-general-overview-with-focus-on-the-vesicular-monoamine-transporter-2-inhibitors
#17
Nicki Niemann, Joseph Jankovic
Tardive dyskinesia (TD) encompasses the spectrum of iatrogenic hyperkinetic movement disorders following exposure to dopamine receptor-blocking agents (DRBAs). Despite the advent of atypical or second- and third-generation antipsychotics with a presumably lower risk of complications, TD remains a persistent and challenging problem. Prevention is the first step in mitigating the risk of TD, but early recognition, gradual withdrawal of offending medications, and appropriate treatment are also critical. As TD is often a persistent and troublesome disorder, specific antidyskinetic therapies are often needed for symptomatic relief...
February 26, 2018: Drugs
https://www.readbyqxmd.com/read/29478811/non-competitive-antagonists-of-nmda-and-ampa-receptors-decrease-seizure-induced-c-fos-protein-expression-in-the-cerebellum-and-protect-against-seizure-symptoms-in-adult-rats
#18
Zoltán Tóth, András Mihály, Adrienne Mátyás, Beáta Krisztin-Péva
The aim of the present study was to examine the role of ionotropic glutamate receptors in the cerebellum during generalized seizures. Epileptic neuronal activation was evaluated through the immunohistochemical detection of c-fos protein in the cerebellar cortex. Generalized seizures were precipitated by the intraperitoneal injection of 4-aminopyridine. The animals were pretreated with the NMDA receptor antagonists MK-801 (2 mg/kg), amantadine (50 mg/kg), and the AMPA receptor antagonist GYKI 52466 hydrochloride (50 mg/kg)...
February 22, 2018: Acta Histochemica
https://www.readbyqxmd.com/read/29454493/updating-the-recommendations-for-treatment-of-tardive-syndromes-a-systematic-review-of-new-evidence-and-practical-treatment-algorithm
#19
REVIEW
Roongroj Bhidayasiri, Onanong Jitkritsadakul, Joseph H Friedman, Stanley Fahn
BACKGROUND: Management of tardive syndromes (TS) is challenging, with only a few evidence-based therapeutic algorithms reported in the American Academy of Neurology (AAN) guideline in 2013. OBJECTIVE: To update the evidence-based recommendations and provide a practical treatment algorithm for management of TS by addressing 5 questions: 1) Is withdrawal of dopamine receptor blocking agents (DRBAs) an effective TS treatment? 2) Does switching from typical to atypical DRBAs reduce TS symptoms? 3) What is the efficacy of pharmacologic agents in treating TS? 4) Do patients with TS benefit from chemodenervation with botulinum toxin? 5) Do patients with TS benefit from surgical therapy? METHODS: Systematic reviews were conducted by searching PsycINFO, Ovid MEDLINE, PubMed, EMBASE, Web of Science and Cochrane for articles published between 2012 and 2017 to identify new evidence published after the 2013 AAN guidelines...
February 5, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29443731/recovery-of-an-injured-corticofugal-tract-from-the-supplementary-motor-area-in-a-patient-with-traumatic-brain-injury-a-case-report
#20
Sung Ho Jang, Seong Ho Kim, Jeong Pyo Seo
RATIONALE: We report on a patient with traumatic brain injury who showed motor recovery concurrent with recovery of injured corticofugal tracts (CFTs), diagnosed by diffusion tensor tractography (DTT). PATIENT CONCERNS: Four weeks after onset, when the patient started rehabilitation, he showed severe weakness of both upper and lower extremities [Motricity Index (MI, full score: 100/100): 9/30]. DIAGNOSES: A 29-year-old male patient underwent conservative management for traumatic hemorrhages in both frontal lobes and right thalamus resulting from a car accident...
February 2018: Medicine (Baltimore)
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