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https://www.readbyqxmd.com/read/29454493/updating-the-recommendations-for-treatment-of-tardive-syndromes-a-systematic-review-of-new-evidence-and-practical-treatment-algorithm
#1
REVIEW
Roongroj Bhidayasiri, Onanong Jitkritsadakul, Joseph H Friedman, Stanley Fahn
BACKGROUND: Management of tardive syndromes (TS) is challenging, with only a few evidence-based therapeutic algorithms reported in the American Academy of Neurology (AAN) guideline in 2013. OBJECTIVE: To update the evidence-based recommendations and provide a practical treatment algorithm for management of TS by addressing 5 questions: 1) Is withdrawal of dopamine receptor blocking agents (DRBAs) an effective TS treatment? 2) Does switching from typical to atypical DRBAs reduce TS symptoms? 3) What is the efficacy of pharmacologic agents in treating TS? 4) Do patients with TS benefit from chemodenervation with botulinum toxin? 5) Do patients with TS benefit from surgical therapy? METHODS: Systematic reviews were conducted by searching PsycINFO, Ovid MEDLINE, PubMed, EMBASE, Web of Science and Cochrane for articles published between 2012 and 2017 to identify new evidence published after the 2013 AAN guidelines...
February 5, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29443731/recovery-of-an-injured-corticofugal-tract-from-the-supplementary-motor-area-in-a-patient-with-traumatic-brain-injury-a-case-report
#2
Sung Ho Jang, Seong Ho Kim, Jeong Pyo Seo
RATIONALE: We report on a patient with traumatic brain injury who showed motor recovery concurrent with recovery of injured corticofugal tracts (CFTs), diagnosed by diffusion tensor tractography (DTT). PATIENT CONCERNS: Four weeks after onset, when the patient started rehabilitation, he showed severe weakness of both upper and lower extremities [Motricity Index (MI, full score: 100/100): 9/30]. DIAGNOSES: A 29-year-old male patient underwent conservative management for traumatic hemorrhages in both frontal lobes and right thalamus resulting from a car accident...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29441189/neuroleptic-malignant-syndrome-a-case-responding-to-electroconvulsive-therapy-plus-bupropion
#3
Quintí Foguet-Boreu, Montse Coll-Negre, Montse Serra-Millàs, Miquel Cavalleria-Verdaguer
Neuroleptic malignant syndrome (NMS) is a severe motor syndrome occurring as a consequence of neuroleptic treatment. We present a case of a 67-year-old Caucasian woman with a history of a major depressive disorder with psychotic features. During her third hospital admission, symptoms of autonomic instability, hyperpyrexia, severe extrapyramidal side effects, and delirium appeared, suggesting NMS due to concomitant treatment with risperidone and quetiapine, among other drugs. Despite several consecutive pharmacological treatments (lorazepam, bromocriptine and amantadine) and prompt initiation of electroconvulsive therapy (ECT), clinical improvement was observed only after combining bupropion with ECT...
January 8, 2018: Clinics and Practice
https://www.readbyqxmd.com/read/29433806/non-vmat2-inhibitor-treatments-for-the-treatment-of-tardive-dyskinesia
#4
REVIEW
Chih-Chun Lin, William G Ondo
Although VMAT2-inhibitors are now established as first-line treatment for tardive dyskinesia, not all patients respond to, or tolerate them. Numerous other agents have been adopted to treat tardive dyskinesia, but with variable results and generally lower quality methodologic reports. Amantadine is the most promising but benzodiazepines, branched chain neutral amino acids, Vitamin B6, several nutraceuticals, and botulinum toxin injections might help some patients. In all cases, better placebo controlled trials are needed before definitive recommendations can be made...
February 5, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29432286/effect-of-concomitant-medications-on-the-safety-and-efficacy-of-extended-release-carbidopa-levodopa-ipx066-in-patients-with-advanced-parkinson-disease-a-post-hoc-analysis
#5
Peter A LeWitt, Leo Verhagen Metman, Robert Rubens, Sarita Khanna, Sherron Kell, Suneel Gupta
OBJECTIVES: Extended-release (ER) carbidopa-levodopa (CD-LD) (IPX066/RYTARY/NUMIENT) produces improvements in "off" time, "on" time without troublesome dyskinesia, and Unified Parkinson Disease Rating Scale scores compared with immediate-release (IR) CD-LD or IR CD-LD plus entacapone (CLE). Post hoc analyses of 2 ER CD-LD phase 3 trials evaluated whether the efficacy and safety of ER CD-LD relative to the respective active comparators were altered by concomitant medications (dopaminergic agonists, monoamine oxidase B [MAO-B] inhibitors, or amantadine)...
February 9, 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29416937/spinocerebellar-ataxia-27-a-review-and-characterization-of-an-evolving-phenotype
#6
REVIEW
Christopher L Groth, Brian D Berman
Background: Spinocerebellar ataxia (SCA) is an uncommon form of progressive cerebellar ataxia with multiple genetic causes and marked variability in phenotypic expression even across patients with identical genetic abnormalities. SCA27 is a recently identified SCA caused by mutations in the Fibroblast Growth Factor 14 gene, with a phenotypic expression that is only beginning to be fully appreciated. We report here a case of a 70-year-old male who presented with slowly worsening tremor and gait instability that began in his early adulthood along with additional features of parkinsonism on examination...
2018: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/29391078/prescribing-pattern-for-parkinson-s-disease-in-indian-community-before-referral-to-tertiary-center
#7
Pratibha Surathi, Nitish Kamble, Ketaki Swapnil Bhalsing, Ravi Yadav, Pramod Kumar Pal
BACKGROUND: Several factors determine the choice of medications in patients with Parkinson's disease (PD). We aimed to analyze the pattern of prescription of drugs in patients with PD before attending a tertiary-care center. METHODS: The study included chart review of 800 PD patients attending the Department of Neurology of the National Institute of Mental Health and Neurosciences in Bangalore, India. RESULTS: The mean age at onset was 51...
November 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29387966/glutamatergic-mechanisms-in-l-dopa-induced-dyskinesia-and-therapeutic-implications
#8
Manuela Mellone, Fabrizio Gardoni
Overactivation of the glutamatergic synapse leading to maladaptive synaptic plasticity in the basal ganglia is a well-demonstrated process involved in the onset of L-DOPA-induced dyskinesia (LID). Changes in glutamate release are paralleled by compensatory modifications of the expression and/or synaptic localization of both ionotropic and metabotropic glutamate receptors (mGluRs). Accordingly, compounds targeting N-methyl-D-aspartate glutamate receptors (NMDARs) and specific subtypes of metabotropic glutamate receptors (mGluR4 and mGluR5) have been tested both in preclinical and clinical studies...
January 31, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29381960/disabling-tremor-induced-by-long-term-use-of-sodium-valproate-and-lamotrigine-case-report
#9
Zhong-Fang He, Jun Chen, Chao-Ning Zhou, Zhi Rao, Xiao-Hua Wang
RATIONALE: Sodium valproate (VPA) and lamotrigine (LTG) are widely used antiepileptic drugs, disabling postural, and action tremors after using LTG with VPA were reported in 1993. However, in this study, we describe a patient in whom disabling resting-type tremor induced by 2-year use of VPA and LTG. PATIENT CONCERNS: A 50-year old man was referred to department of neurology because of involuntary upper limbs resting-type tremor with high amplitude that had begun 6 months previously and progressively worsened, and he could not work on the day of visit...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29377520/comparative-pharmacological-study-of-common-nmda-receptor-open-channel-blockers-regarding-their-affinity-and-functional-activity-towards-glun2a-and-glun2b-nmda-receptors
#10
Bernhard Wünsch, Louisa Temme, Dirk Schepmann, Julian A Schreiber, Bastian Frehland
Since only a few studies investigated the affinity and functional activity of NMDA receptor open channel blockers under same assay conditions, a comparative study of common open channel blockers is of major interest. The pharmacological activity of MK-801, phencyclidine, dexoxadrol, etoxadrol, (S)- and (R)-ketamine, dextromethorphan, memantine and amantadine was analyzed under same uniform assay conditions. The affinity towards the PCP and ifenprodil binding sites was recorded in radioligand binding assays...
January 27, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29368539/safety-and-efficacy-of-ads-5102-amantadine-extended-release-capsules-to-improve-walking-in-multiple-sclerosis-a-randomized-placebo-controlled-phase-2-trial
#11
Jeffrey A Cohen, Samuel F Hunter, Theodore R Brown, Mark Gudesblatt, Ben W Thrower, Lily Llorens, Cindy J Souza-Prien, April E Ruby, David N Chernoff, Rajiv Patni
BACKGROUND: Walking impairment causes disability and reduced quality of life in patients with multiple sclerosis (MS). OBJECTIVE: Characterize the safety and efficacy of ADS-5102 (amantadine) extended release capsules, 274 mg administered once daily at bedtime in patients with MS with walking impairment. METHODS: This randomized, double-blind, placebo-controlled, 4-week study was conducted at 14 trial sites in the United States. Study objectives included safety and tolerability of ADS-5102, and efficacy assessments (Timed 25-Foot Walk (T25FW), Timed Up and Go (TUG), 2-Minute Walk Test, and Multiple Sclerosis Walking Scale-12)...
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29359952/pharmacological-management-of-agitation-among-individuals-with-moderate-to-severe-acquired-brain-injury-a-systematic-review
#12
Swati Mehta, Amanda McIntyre, Shannon Janzen, Jerome Iruthayarajah, Ali Bateman, Robert Teasell
OBJECTIVE: To conduct a systematic review examining the effectiveness of pharmacological management of agitation among individuals with acquired brain injury (ABI). DATA SOURCES: MEDLINE, CINAHL, EMBASE, and PsycINFO databases were searched for all relevant articles published in English from 1980 to January 2016. STUDY SELECTION: Studies were included for analysis all participants had moderate to severe ABI, n ≥ 3, and a pharmacological intervention was provided for the treatment of agitation and its effectiveness was assessed...
January 23, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29351330/use-of-influenza-antivirals-in-patients-hospitalized-in-hong-kong-2000-2015
#13
Benjamin J Cowling, Celine S L Chui, Wey Wen Lim, Peng Wu, Christopher K M Hui, J S Malik Peiris, Esther W Chan
OBJECTIVES: We aimed to describe patterns in the usage of antivirals to treat influenza virus infection in hospitals in Hong Kong from 2000 through 2015. METHODS: We analyzed centralized electronic health records that included dispensation information and diagnosis codes. Information collected on admissions included patient age, sex, admission year and month, and medications dispensed, and were matched with the first 15 discharge diagnosis codes. We divided monthly admission episodes by relevant population denominators to obtain admission rates, and stratified analyses by drug type, age group, and diagnosis codes...
2018: PloS One
https://www.readbyqxmd.com/read/29342497/non-antipsychotic-catecholaminergic-drugs-for-antipsychotic-induced-tardive-dyskinesia
#14
REVIEW
Hany G El-Sayeh, John Rathbone, Karla Soares-Weiser, Hanna Bergman
BACKGROUND: Tardive dyskinesia (TD) is a disabling movement disorder associated with the prolonged use of antipsychotic medication. Several strategies have been examined in the treatment of TD. Currently, however, there is no clear evidence of the effectiveness of these drugs in TD and they have been associated with many side effects. One particular strategy would be to use pharmaceutical agents which are known to influence the catecholaminergic system at various junctures. OBJECTIVES: 1...
January 18, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29310211/on-line-competitive-host-guest-interactions-in-a-turn-on-fluorometric-method-to-amantadine-determination-in-human-serum-and-pharmaceutical-formulations
#15
María Del Pozo, Ángela Fernández, Carmen Quintana
A competitive assay between the antiviral Amantadine and the dye Thionine for the Cucurbit[8]uril cavity was carried out in a flow injection analysis system for the indirect fluorescence detection of Amantadine. Both, Cucurbit[7]uril and Cucurbit[8]uril Thionine complexes were evaluated for the competitive assay. The use of a 12-port injection valve allows the on-line reaction in the flow system. Once optimized all the experimental variables, the methodology developed allows the detection of Amantadine at the 0...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29251816/interaction-of-antivirals-with-a-heptameric-bundle-model-of-the-p7-protein-of-hepatitis-c-virus
#16
Sophie Dahl, Monoj Mon Kalita, Wolfgang B Fischer
A series of ligands are known experimentally to affect the infectivity cycle of the hepatitis C virus. The target protein for the ligands is proposed to be p7, a 63 amino acid polytopic channel forming protein, with possibly two transmembrane domains. Protein p7 is found to assemble into functional oligomers of various sizes, depending on the genotype (GT). Nine ligands are docked to various sites of a computationally derived heptameric bundle of p7 of GT1a. The energy of interaction, here binding energy, is calculated using three different docking programs (Autodock, MOE, LeadIT)...
December 18, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29244026/jnj-63623872-treatment-in-adult-volunteers-experimentally-inoculated-with-live-influenza-virus-a-phase-iia-randomized-double-blind-placebo-controlled-study
#17
Jose M Trevejo, Mohammed Asmal, Johan Vingerhoets, Ramon Polo, Sarah Robertson, Ying Jiang, Tara L Kieffer, Lorant Leopold
BACKGROUND: JNJ-63623872 is a novel, non-nucleoside polymerase complex inhibitor with in vitro activity against influenza A virus, including pandemic 2009 H1N1, H7N9, H5N1 strains as well as neuraminidase-and amantadine-resistant strains. METHODS: Randomized, double-blind, placebo-controlled, Phase 2a study. Healthy volunteers (N = 104) were inoculated with an influenza A/Wisconsin/67/2005 (H3N2) challenge virus. 72 received JNJ-63623872 and 32 placebo. JNJ-63623872 was dosed for 5 days once daily from 24 hours after viral inoculation at four dose levels: 100 mg, 400 mg, loading dose 900/600 mg and loading dose 1200/600 mg...
December 15, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/29226687/validation-of-a-new-scoring-scale-for-behavioral-assessment-of-l-dopa-induced-dyskinesia-in-the-rat-a-new-tool-for-early-decision-making-in-drug-development
#18
Simon Loiodice, Anne-Sophie Denibaud, Wendy Deffains, Magali Alix, Pierre Montagne, Marine Seffals, Christophe Drieu La Rochelle
The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated non-human primate (NHP) has been described as the most translatable model for experimental reproduction of L-dopa-induced dyskinesia (LID). However, from a drug discovery perspective, the risk associated with investment in this type of model is high due to the time and cost. The 6-hydroxydopamine (6-OHDA) rat dyskinesia model is recommended for testing compounds but relies on onerous, and non-standard behavioral rating scales. We sought to develop a simplified and sensitive method aiming at assessing LID in the rat...
December 11, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29210473/binding-pathway-analysis-of-influenza-virus-m2-channel-blockers-by-metadynamics-simulation
#19
Yuri Sakai, Atsushi Kawaguchi, Kyosuke Nagata, Takatsugu Hirokawa
M2 protein of influenza A virus is a proton channel spanning the viral envelope. This proton channel activity is required for uncoating of viral particles and equilibrating the pH across the trans-Golgi apparatus to prevent a conformational change of hemagglutinin. Amantadine is an anti-influenza A virus drug which inhibits M2 proton channel activity by binding to the channel pore, however, the majority of currently circulating influenza A viruses are amantadine-resistant. The most prevalent resistant mutation is a substitution from Ser31 to Asn31 in M2...
December 6, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/29197671/the-in-vitro-renal-cell-toxicity-of-some-unconventional-anticancer-phenanthroline-based-platinum-ii-complexes
#20
Neville S Ng, Ming J Wu, Simon J Myers, Janice R Aldrich-Wright
The cytotoxicity of platinum(II) complexes coordinated to a chiral diamine, 1S,2S-diaminocyclohexane or 1R,2R-diaminocyclohexane and 1,10-phenanthroline or 3,4,7,8-tetramethyl-1,10-phenanthroline has been investigated in the renal proximal tubule HK-2 cell line. All platinum(II) complexes exhibited lower cytotoxicity in HK-2 cells (IC50 1.7-25μM) than in A2780 ovarian cancer cells or cisplatin-resistant A2780cisR cells (IC50 0.2-2.1μM) (at 48h). PHENSS ([Pt(1,10-phenanthroline)(1S,2S-dach)]2+) induced apoptosis and necrosis in ovarian cancer cells at concentrations that are relatively cytostatic to renal cells...
November 30, 2017: Journal of Inorganic Biochemistry
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