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https://www.readbyqxmd.com/read/26888787/clinical-predictors-of-patient-related-delay-in-the-vienna-st-elevation-myocardial-infarction-network-and-impact-on-long-term-mortality
#1
Bernhard Jäger, Serdar Farhan, Miklos Rohla, Günter Christ, Andrea Podczeck-Schweighofer, Wolfgang Schreiber, Anton N Laggner, Franz Weidinger, Thomas Stefenelli, Georg Delle-Karth, Alfred Kaff, Gerald Maurer, Kurt Huber
BACKGROUND: While contributors to system delay in ST-elevation myocardial infarction (STEMI) are well described, predictors of patient-related delays are less clear. The aim of this study was to identify predictors that cause delayed diagnosis of STEMI in a metropolitan system of care (VIENNA STEMI network) and to investigate a possible association with long-term mortality. METHODS: The study population investigated consisted of 2366 patients treated for acute STEMI in the Vienna STEMI registry from 2003-2009...
February 17, 2016: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/26686385/development-of-an-interleukin-1%C3%AE-vaccine-in-patients-with-type-2-diabetes
#2
Claudia Cavelti-Weder, Katharina Timper, Eleonora Seelig, Cornelia Keller, Martin Osranek, Ute Lässing, Gunther Spohn, Patrik Maurer, Philipp Müller, Gary T Jennings, Joerg Willers, Philippe Saudan, Marc Y Donath, Martin F Bachmann
Interleukin-1β (IL-1β) is a key cytokine involved in inflammatory illnesses including rare hereditary diseases and common chronic inflammatory conditions as gout, rheumatoid arthritis, and type 2 diabetes mellitus, suggesting reduction of IL-1β activity as new treatment strategy. The objective of our study was to assess safety, antibody response, and preliminary efficacy of a novel vaccine against IL-1β. The vaccine hIL1bQb consisting of full-length, recombinant IL-1β coupled to virus-like particles was tested in a preclinical and clinical, randomized, placebo-controlled, double-blind study in patients with type 2 diabetes...
May 2016: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/26362759/dense-genotyping-of-immune-related-loci-in-idiopathic-inflammatory-myopathies-confirms-hla-alleles-as-the-strongest-genetic-risk-factor-and-suggests-different-genetic-background-for-major-clinical-subgroups
#3
Simon Rothwell, Robert G Cooper, Ingrid E Lundberg, Frederick W Miller, Peter K Gregersen, John Bowes, Jiri Vencovsky, Katalin Danko, Vidya Limaye, Albert Selva-O'Callaghan, Michael G Hanna, Pedro M Machado, Lauren M Pachman, Ann M Reed, Lisa G Rider, Joanna Cobb, Hazel Platt, Øyvind Molberg, Olivier Benveniste, Pernille Mathiesen, Timothy Radstake, Andrea Doria, Jan De Bleecker, Boel De Paepe, Britta Maurer, William E Ollier, Leonid Padyukov, Terrance P O'Hanlon, Annette Lee, Christopher I Amos, Christian Gieger, Thomas Meitinger, Juliane Winkelmann, Lucy R Wedderburn, Hector Chinoy, Janine A Lamb
OBJECTIVES: The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of rare autoimmune diseases characterised by muscle weakness and extramuscular manifestations such as skin rashes and interstitial lung disease. We genotyped 2566 IIM cases of Caucasian descent using the Immunochip; a custom array covering 186 established autoimmune susceptibility loci. The cohort was predominantly comprised of patients with dermatomyositis (DM, n=879), juvenile DM (JDM, n=481), polymyositis (PM, n=931) and inclusion body myositis (n=252) collected from 14 countries through the Myositis Genetics Consortium...
August 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/25654950/electrogustometry-thresholds-tongue-tip-vascularization-and-density-and-morphology-of-the-fungiform-papillae-in-diabetes
#4
P Pavlidis, H Gouveris, G Kekes, J Maurer
OBJECTIVES: The aim of this study was to investigate, in parallel, changes in electrogustometric (EGM) thresholds, the morphology and density of the fungiform papillae (fPap), and the shape and density of the vessels at the tip of the human tongue in patients with diabetes mellitus (DM). METHODOLOGY: In 36 patients (19 females, 17 males; 12 subjects with type 1 DM and 24 subjects with type 2 DM), we recorded bilateral EGM-thresholds at the areas innervated by the chorda tympani, the glossopharyngeal nerves, and the greater petrosal nerves...
2014: B-ENT
https://www.readbyqxmd.com/read/25640450/chemerin-and-prediction-of-diabetes-mellitus-type-2
#5
Thomas Bobbert, Franziska Schwarz, Antje Fischer-Rosinsky, Lukas Maurer, Matthias Möhlig, A F H Pfeiffer, Knut Mai, Joachim Spranger
OBJECTIVE: Insulin resistance and subclinical inflammation are characteristics in the development of type 2 diabetes mellitus (T2DM). The adipokine chemerin has been associated with both factors. The aim of this study was to analyse whether chemerin predicts T2DM. DESIGN: Blood samples of 440 participants of the Metabolic-Syndrome Berlin-Potsdam (MesyBepo) follow-up study without diabetes at baseline were available for chemerin measurement. Mean follow-up of participants was 5·3 years...
June 2015: Clinical Endocrinology
https://www.readbyqxmd.com/read/25135387/systemic-ropivacaine-diminishes-pain-sensitization-processes-a-randomized-double-blinded-placebo-controlled-crossover-study-in-healthy-volunteers
#6
Yéri Haller, Andreas R Gantenbein, Patrick Willimann, Donat R Spahn, Konrad Maurer
INTRODUCTION: Ropivacaine is a local anesthetic widely used for regional anesthesia. One of its advantages is low toxicity at plasma concentrations reached systemically during continuous peripheral or central nervous block. The objective of this study was to test the effect of systemic ropivacaine on pain, hyperalgesia, dynamic allodynia, and flare response. METHODS: This randomized, double-blinded, placebo-controlled, crossover study was carried out in at the Clinical Trials Centre, University of Zurich, Switzerland...
June 2014: Pain and Therapy
https://www.readbyqxmd.com/read/25104522/hfpef-is-splitting-into-distinct-phenotypes-by-comorbidities-the-pathway-forward
#7
EDITORIAL
Mathew S Maurer, Donna Mancini
No abstract text is available yet for this article.
August 12, 2014: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/25051347/interplay-between-genetic-and-clinical-variables-affecting-platelet-reactivity-and-cardiac-adverse-events-in-patients-undergoing-percutaneous-coronary-intervention
#8
Jolanta M Siller-Matula, Irene M Lang, Thomas Neunteufl, Marek Kozinski, Gerald Maurer, Katarzyna Linkowska, Tomasz Grzybowski, Jacek Kubica, Bernd Jilma
Several clinical and genetic variables are associated with influencing high on treatment platelet reactivity (HTPR). The aim of the study was to propose a path model explaining a concurrent impact among variables influencing HTPR and ischemic events. In this prospective cohort study polymorphisms of CYP2C19*2, CYP2C19*17, ABCB1, PON1 alleles and platelet function assessed by Multiple Electrode Aggregometry were assessed in 416 patients undergoing percutaneous coronary intervention treated with clopidogrel and aspirin...
2014: PloS One
https://www.readbyqxmd.com/read/23900047/stent-thrombosis-with-ticagrelor-versus-clopidogrel-in-patients-with-acute-coronary-syndromes-an-analysis-from-the-prospective-randomized-plato-trial
#9
RANDOMIZED CONTROLLED TRIAL
P Gabriel Steg, Robert A Harrington, Håkan Emanuelsson, Hugo A Katus, Kenneth W Mahaffey, Bernhard Meier, Robert F Storey, Daniel M Wojdyla, Basil S Lewis, Gerald Maurer, Lars Wallentin, Stefan K James
BACKGROUND: We aimed to describe the effects of ticagrelor versus clopidogrel on stent thrombosis in the Platelet Inhibition and Patient Outcomes (PLATO) trial. METHODS AND RESULTS: Of 18 624 patients hospitalized for acute coronary syndromes, 11 289 (61%) had at least 1 intracoronary stent. Ticagrelor reduced stent thrombosis compared with clopidogrel across all definitions: definite, 1.37% (n=71) versus 1.93% (n=105; hazard ratio [HR], 0.67; 95% confidence interval [CI], 0...
September 3, 2013: Circulation
https://www.readbyqxmd.com/read/23754947/altered-splicing-of-the-bin1-muscle-specific-exon-in-humans-and-dogs-with-highly-progressive-centronuclear-myopathy
#10
Johann Böhm, Nasim Vasli, Marie Maurer, Belinda Cowling, G Diane Shelton, Wolfram Kress, Anne Toussaint, Ivana Prokic, Ulrike Schara, Thomas James Anderson, Joachim Weis, Laurent Tiret, Jocelyn Laporte
Amphiphysin 2, encoded by BIN1, is a key factor for membrane sensing and remodelling in different cell types. Homozygous BIN1 mutations in ubiquitously expressed exons are associated with autosomal recessive centronuclear myopathy (CNM), a mildly progressive muscle disorder typically showing abnormal nuclear centralization on biopsies. In addition, misregulation of BIN1 splicing partially accounts for the muscle defects in myotonic dystrophy (DM). However, the muscle-specific function of amphiphysin 2 and its pathogenicity in both muscle disorders are not well understood...
June 2013: PLoS Genetics
https://www.readbyqxmd.com/read/23668396/diabetes-and-cancer-two-diseases-with-obesity-as-a-common-risk-factor
#11
REVIEW
S K Garg, H Maurer, K Reed, R Selagamsetty
There is a growing body of evidence to support a connection between diabetes (predominantly type 2), obesity and cancer. Multiple meta-analyses of epidemiological data show that people with diabetes are at increased risk of developing many different types of cancers, along with an increased risk of cancer mortality. Several pathophysiological mechanisms for this relationship have been postulated, including insulin resistance and hyperinsulinaemia, enhanced inflammatory processes, dysregulation of sex hormone production and hyperglycaemia...
February 2014: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/23452622/diabetic-status-and-the-relation-of-the-three-domains-of-glycemic-control-to-mortality-in-critically-ill-patients-an-international-multicenter-cohort-study
#12
MULTICENTER STUDY
James S Krinsley, Moritoki Egi, Alex Kiss, Amin N Devendra, Philipp Schuetz, Paula M Maurer, Marcus J Schultz, Roosmarijn T M van Hooijdonk, Morita Kiyoshi, Iain M J Mackenzie, Djillali Annane, Peter Stow, Stanley A Nasraway, Sharon Holewinski, Ulrike Holzinger, Jean-Charles Preiser, Jean-Louis Vincent, Rinaldo Bellomo
INTRODUCTION: Hyperglycemia, hypoglycemia, and increased glycemic variability have each been independently associated with increased risk of mortality in critically ill patients. The role of diabetic status on modulating the relation of these three domains of glycemic control with mortality remains uncertain. The purpose of this investigation was to determine how diabetic status affects the relation of hyperglycemia, hypoglycemia, and increased glycemic variability with the risk of mortality in critically ill patients...
2013: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/22305813/dual-non-responsiveness-to-antiplatelet-treatment-is-a-stronger-predictor-of-cardiac-adverse-events-than-isolated-non-responsiveness-to-clopidogrel-or-aspirin
#13
Jolanta M Siller-Matula, Georg Delle-Karth, Günter Christ, Thomas Neunteufl, Gerald Maurer, Kurt Huber, Alexander Tolios, Christa Drucker, Bernd Jilma
BACKGROUND: High platelet reactivity (HPR) under treatment with clopidogrel or aspirin is associated with adverse outcome. We aimed to investigate whether high platelet reactivity (HPR) to both aspirin and clopidogrel is a stronger predictor of adverse events compared to isolated HPR to clopidogrel or aspirin. METHODS: In this prospective cohort study platelet reactivity to adenosine diphosphate (ADP) and arachidonic acid (AA) was assessed by Multiple Electrode Aggregometry (MEA) in 403 patients undergoing percutaneous coronary intervention...
July 31, 2013: International Journal of Cardiology
https://www.readbyqxmd.com/read/22260716/phenotyping-vs-genotyping-for-prediction-of-clopidogrel-efficacy-and-safety-the-pegasus-pci-study
#14
COMPARATIVE STUDY
J M Siller-Matula, G Delle-Karth, I M Lang, T Neunteufl, M Kozinski, J Kubica, G Maurer, K Linkowska, T Grzybowski, K Huber, B Jilma
BACKGROUND: Prognostic values of genotyping and phenotyping for assessment of clopidogrel responsiveness have been shown in independent studies. OBJECTIVES: To compare different assays for prediction of events during long-term follow-up. METHODS: In this prospective cohort study polymorphisms of CYP2C19*2 and CYP2C19*17 alleles, vasodilator-stimulated phosphoprotein phosphorylation (VASP) assay, multiple electrode aggregometry (MEA), cone and platelet analyser (CPA) and platelet function analyser (PFA-100) were performed in 416 patients undergoing percutaneous coronary intervention...
April 2012: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/21870203/pharmacodynamic-model-of-sodium-glucose-transporter-2-sglt2-inhibition-implications-for-quantitative-translational-pharmacology
#15
Tristan S Maurer, Avijit Ghosh, Nahor Haddish-Berhane, Aarti Sawant-Basak, Carine M Boustany-Kari, Li She, Michael T Leininger, Tong Zhu, Meera Tugnait, Xin Yang, Emi Kimoto, Vincent Mascitti, Ralph P Robinson
Sodium-glucose co-transporter-2 (SGLT2) inhibitors are an emerging class of agents for use in the treatment of type 2 diabetes mellitus (T2DM). Inhibition of SGLT2 leads to improved glycemic control through increased urinary glucose excretion (UGE). In this study, a biologically based pharmacokinetic/pharmacodynamic (PK/PD) model of SGLT2 inhibitor-mediated UGE was developed. The derived model was used to characterize the acute PK/PD relationship of the SGLT2 inhibitor, dapagliflozin, in rats. The quantitative translational pharmacology of dapagliflozin was examined through both prospective simulation and direct modeling of mean literature data obtained for dapagliflozin in healthy subjects...
December 2011: AAPS Journal
https://www.readbyqxmd.com/read/21391411/using-a-brief-10-item-generic-measure-of-quality-of-life-in-english-and-spanish-speaking-diabetic-patients
#16
Maria I Zapata-Vega, James Rivera, Nancy Tarlin, Inci Bijan, Martin Maurer
OBJECTIVES: Validation of the Multicultural Quality of Life Index (MQLI), a 10-item self-rated generic multilingual quality of life (QOL) measure in ethnically-diverse diabetic patients. METHODS: Diabetic adult patients (n = 180) in New York City completed the MQLI, English or Spanish version. Its internal consistency, factorial structure, and construct validity were analyzed. Depression screening (PHQ-9) scores were used to divide subjects into two sub-samples with presumed different QOL levels...
2010: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/21365240/gastric-emptying-of-solids-and-liquids-for-evaluation-for-gastroparesis
#17
Priyanka Sachdeva, Nidhi Malhotra, Murali Pathikonda, Umar Khayyam, Robert S Fisher, Alan H Maurer, Henry P Parkman
BACKGROUND: Gastric emptying scintigraphy (GES) of solids is typically used to evaluate for gastroparesis. AIMS: The purpose of this study was to determine the value of simultaneously measuring gastric emptying of liquids and solids for assessing patients for delayed gastric emptying. METHODS: A total of 596 patients at our institution from September 2007 to January 2010 underwent GES with assessment of both solid and liquid gastric emptying...
April 2011: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/19742140/influence-of-diabetes-on-the-interpretation-of-pet-scans-in-patients-with-esophageal-cancer
#18
Michael Haley, Andre Konski, Tianyu Li, Jonathan D Cheng, Alan Maurer, Oleh Haluszka, Walter Scott, Neal J Meropol, Steven J Cohen, Gary Freedman
PURPOSE: Patients with diabetes mellitus (DM) can have altered sugar transport into cells, potentially affecting the results of 18-FDG PET scans. The specific aim of this study was to determine the effect of DM on pre- and post-treatment standard uptake value (SUV) scores in patients undergoing chemoradiotherapy for esophageal cancer. METHODS: Patients with locally advanced esophageal carcinoma undergoing preoperative or definitive chemoradiotherapy underwent pre- and posttreatment 18-FDG PET scans...
July 2009: Gastrointestinal Cancer Research: GCR
https://www.readbyqxmd.com/read/19688724/alterations-of-the-podocyte-proteome-in-response-to-high-glucose-concentrations
#19
Sandra Schordan, Eric Schordan, Nicole Endlich, Maja T Lindenmeyer, Catherine Meyer-Schwesinger, Tobias N Meyer, Jürgen Giebel, Clemens D Cohen, Karlhans Endlich, Martin H Maurer
Diabetic nephropathy is one of the most common complications of diabetes mellitus and the leading cause of end-stage renal disease. A reduction in podocyte number has been documented in the kidneys of these patients. To identify the molecular changes in podocytes that are primarily caused by high glucose (HG) concentrations and not by secondary alterations (e.g. glomerular hypertension), we investigated the protein expression profiles in a podocyte cell line under long-term HG exposure (30 versus 10 mM for 2 wk)...
October 2009: Proteomics
https://www.readbyqxmd.com/read/19251370/poultry-litter-as-a-source-of-gastrointestinal-helminth-infections
#20
V Maurer, Z Amsler, E Perler, F Heckendorn
The aim of this study carried out in 6 commercial layer houses was to examine the effect of litter management on water content, helminth egg count and litter infectiousness with the intestinal nematodes Ascaridia galli, Heterakis gallinarum, and Capillaria spp. Three types of litter management were established in each layer house in parallel: in compartment A, litter was left undisturbed, in compartment B, wet litter was replaced and in compartment C, new litter material was added weekly. Dry matter (DM) contents of the litter and parasitological parameters (helminth egg concentration in litter samples, faecal egg counts (FECs) in the permanent layer flocks, helminth prevalence and burdens in two series of tracer animals) were determined every 4 weeks during the first 32 weeks of one laying period...
May 12, 2009: Veterinary Parasitology
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