Read by QxMD icon Read


Y X Mao, W J Cai, X Y Sun, P P Dai, X M Li, Q Wang, X L Huang, B He, P P Wang, G Wu, J F Ma, S B Huang
Advanced glycation end products (AGEs) can stimulate osteoblast apoptosis and have a critical role in the pathophysiology of diabetic osteoporosis. Mitochondrial abnormalities are closely related to osteoblast dysfunction. However, it remains unclear whether mitochondrial abnormalities are involved in AGE-induced osteoblastic cell apoptosis. Silibinin, a major flavonolignan compound of silimarin, has strong antioxidant and mitochondria-protective properties. In the present study, we explored the possible mitochondrial mechanisms underlying AGE-induced apoptosis of osteoblastic cells and the effect of silibinin on osteoblastic cell apoptosis...
June 4, 2018: Cell Death & Disease
Christos E Kazazis, Angelos A Evangelopoulos, Aris Kollas, Natalia G Vallianou
Milk thistle has been known for more than 2.000 years as a herbal remedy for a variety of disorders. It has mainly been used to treat liver and gallbladder diseases. Silibum marianum, the Latin term for the plant, and its seeds contain a whole family of natural compounds, called flavonolignans. Silimarin is a dry mixture of these compounds; it is extracted after processing with ethanol, methanol, and acetone. Silimarin contains mainly silibin A, silibin B, taxifolin, isosilibin A, isosilibin B, silichristin A, silidianin, and other compounds in smaller concentrations...
2014: Review of Diabetic Studies: RDS
V I Smol'iakova, M B Plotnikov, G A Chernysheva, I S Ivanov, A E Prosenko, N V Kandalintseva
A hepatoprotective effect of thiophan was studied on the model of carbon tetrachloride-induced hepatitis in rats. Therapeutic administration of thiophan repairs the antitoxic function of liver, normalizes cytolysis marker activity, and improves the synthetic function of liver and the carbohydrate and lipid metabolism. The hepatoprotective activity of thiophan is similar to effect of silimarin.
2011: Eksperimental'naia i Klinicheskaia Farmakologiia
M Muthumani, S Milton Prabu
Arsenic (As) compounds are reported as environmental toxicants and human carcinogens. Exposure to arsenic imposes a big health issue worldwide. Silibinin (SB) is a major flavonolignan compound of silimarin and is found in milk thistle of Silybum marianum. It has been reported that silibinin has antioxidant efficacy as metal chelators due to the orientation of its functional groups. However, it has not yet been explored in experimental animals. In view of this fact, the purpose of this study was to delineate the ameliorative role of silibinin against arsenic-induced hepatotoxicity in rats...
May 2012: Toxicology Mechanisms and Methods
Paul J Pockros
A large number of new therapies are in development for chronic hepatitis C including direct-acting antiviral drugs (DAA), which target specific hepatitis C virus enzymes. Two of these compounds have already advanced into phase 3 development in the USA and EU, and many more are in phase 2 trials and likely to advance. In this review, the results of recent studies on ribavirin analogues, nonstructural (NS) 3/4 serine protease inhibitors, NS5B polymerase inhibitors, cyclophilin inhibitors, silimarin components, and thiazolides have been updated...
May 2010: Therapeutic Advances in Gastroenterology
Kandulva Sethuraman Vidyalakshmi, Sulochana Nagarajan, Hannah Rachel Vasanthi, Venkappaya, Victor Rajamanickam
Mussaenda 'dona aurora' (sepals) has been investigated for its hepatoprotective and antioxidant activities. The highest activity was observed in the ethyl acetate fraction. The separation of the ethyl acetate fraction gave two iridoids, sanshiside-D and lamalbide. Sanshiside-D exhibited a hepatoprotective activity greater than silimarin as was evidenced by significant reduction of ALT and AST in the serum enzyme levels.
May 2009: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
V A Khazanov, A I Vengerovsky
In rats with experimental encephalopathy caused by intoxication with 4-pentenoic acid inhibiting beta-oxidation of medium- and long-chain fatty acids, hepatoprotector silimarin inhibited LPO, prevented deenergization and maintained high respiratory activity of brain mitochondria, and increased the rate and coupling of oxidation and phosphorylation. Succinic acid improved oxidation of substrates in motochondria and promoted activation of succinate-dependent ATP generation. Silimarin and succinic acid used together produced a synergistic protective effect on brain mitochondria surpassing the protective effects of individual preparations and prevented LPO activation...
December 2007: Bulletin of Experimental Biology and Medicine
Michael Maes, Ivana Mihaylova, Eugene Bosmans
There is now some evidence that chronic fatigue syndrome is accompanied by an activation of the inflammatory response system and by increased oxidative and nitrosative stress. Nuclear factor kappa beta (NFkappabeta) is the major upstream, intracellular mechanism which regulates inflammatory and oxidative stress mediators. In order to examine the role of NFkappabeta in the pathophysiology of CFS, this study examines the production of NFkappabeta p50 in unstimulated, 10 ng/mL TNF-alpha (tumor necrosis factor alpha) and 50 ng/mL PMA (phorbolmyristate acetate) stimulated peripheral blood lymphocytes of 18 unmedicated patients with CFS and 18 age-sex matched controls...
August 2007: Neuro Endocrinology Letters
F N Gil'miiarova, V M Radomskaia, Iu V Miakisheva, G M Baisheva, Iu V Pervova, N V Spiridonova
The influence of silistrong on the activity of erythrocyte cytoplasmatic dehydrogenases and also purified glyceraldehyde-3-phosphate dehydrogenase (GAPH) was studied. Silistrong and its biologically active components (ethanol and silimarine) were found to activate GAPDH, lactate dehydrogenase (LDH), alpha-glycerophosphate dehydrogenase (GPDH) both in lysates of erythrocytes and in isolated GAPDH. The compounds studied are able to protect these enzymes and also to restore their activity of enzymes modified by hydrogen peroxide...
November 2006: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
A V Rat'kin, A S Saratikov, V S Chuchalin, V N Burkova, V N Frolov
The results of experiments on white rats with CCl4-induced hepatitis showed that the combined introduction of cyclophosphamide and hepatoprotectors of the plant origin (lochein, maksar, silimarin) leads to a decrease in acute toxicity and to less pronounced manifestations of hepatotoxicity of cyclophosphamide. Hepatoprotectors decrease the activity of aminotransferases, reduce the level of bilirubin, normalize the content of protein andpipids in the blood serum, and suppress the development of morphological disorders in the liver...
March 2005: Eksperimental'naia i Klinicheskaia Farmakologiia
L I Geller, L N Gladkikh, M V Griaznova
A ten-day course of karsil (silimarin, legalon) or silibor therapy improved the absorption (as indicated by ueviridin test) and oxidative-antitoxic (as shown by antipyrine test) hepatocyte functions in patients with non-insulin-dependent diabetes mellitus with hepatosis. A similar ten-day course of Liv-52 did not change the studied liver parameters. Inducto-thermal exposure of the splenic area (a 20 min session daily for 5 days) improved the absorption and antitoxic functions of the liver in diabetics. A positive effect of splenic inductothermia persisted for at least two weeks...
September 1993: Problemy E̊ndokrinologii
F Güemes Díaz, C Pérez Muñóz, J Sallent Herránz, E Arias Vallejo
No abstract text is available yet for this article.
February 15, 1974: Revista Clínica Española
Y Sánchez de la Cuesta, T Oporto Ruíz, J Martínez López
No abstract text is available yet for this article.
July 1973: Revista Española de las Enfermedades del Aparato Digestivo
V Alvisi, B Bagni, A D'Ambrosi, G Groothold
No abstract text is available yet for this article.
September 5, 1974: Minerva Medica
T Oporto Ruĩz, J R Alemany Ontiveros, F Sãnchez de la Cuesta, De Alarcõn, R Monfort Albelda, J Aznar Lõpez
No abstract text is available yet for this article.
December 31, 1972: Revista Clínica Española
S I Tabagari, T M Shubitidze, G V Abdushelishvili
Total and nonsedimented activities of lysosomal proteinases were studied in rat liver and kidney tissues after administration of silimarine simultaneously with tetramethylthiuram disulfide (TMTD). Silimarine did not affect the pattern of alterations in total activity of lysosomal proteinases, caused by the TMTD treatment, but the nonsedimented activity of the enzymes studied was normalized. Silimarine appears to exhibit the membrane-stabilizing effect.
September 1988: Voprosy Medit︠s︡inskoĭ Khimii
G Müzes, G Deák, I Láng, K Nékám, V Niederland, J Fehér
A double blind study. Antioxidant and antiperoxidative effects of the free radical scavenger agent silymarin (Legalon) were investigated in patients with chronic alcoholic liver disease in a double blind clinical trial. Six month treatment (at a daily dose of 420 mg) with silymarin significantly enhanced the originally low superoxide dismutase activity of erythrocytes and lymphocytes and also restored the diminished superoxide dismutase expression on lymphocytes as measured by flow-cytofluorimetry. In addition, silymarin therapy markedly increased the serum level of ree--SH groups and the activity of glutathione peroxidase...
April 22, 1990: Orvosi Hetilap
G Martines, M Piva, V Copponi, G Cagnetta
Further systematic study of the relation between drugs and the ultrastructure of the liver is reported with regard to the experimental administration of silimarin to pregnant women and others on the pill. Marked signs of ultrastructural alteration of the REL and biliary cell pole were noted, matched, by evidence of throbophilia and changes in protein activity and lipid synthesis, are noted in these situations, but not when suitable doses of silimarine are taken with the pill. It is suggested that silimarin may prevent and correct liver damage during pregnancy and the administration of oestroprogestins...
July 1979: Archivio Per le Scienze Mediche
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"