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Graham Pawelec
Geriatric oncology, important for the ever-increasing numbers of elderly cancer patients, has thus far focused primarily on tolerance to chemotherapy. With the advent of breakthrough immunomodulatory antibody treatments relying on the patient's own immune system to control the tumor, the issue of immunosenescence becomes extremely important. There is increasingly a valid concern that anti-cancer immunity may be compromised in the elderly due to (i) their low amounts of naïve T cells (potentially leading to holes in the repertoire for neoantigens), (ii) "exhaustion" of potentially tumor-specific memory T cells, and (iii) higher amounts of suppressive cells...
July 13, 2018: Seminars in Immunopathology
Kazuhiro Harada, Sangyoon Lee, Sungchul Lee, Seongryu Bae, Kenji Harada, Hiroyuki Shimada
BACKGROUND: Older adults with cognitive impairment are at higher risk for various health problems. Although previous studies have suggested going outdoors more frequently might be effective to promote health, no longitudinal studies have examined objectively measured outdoor time in this population. This study examined the relationships between changes in objectively measured outdoor time and physical, psychological, and cognitive functions among older adults with cognitive impairments...
June 11, 2018: Archives of Gerontology and Geriatrics
Jimmy Ruiz, Antonius A Miller, Janet A Tooze, Sandrine Crane, William J Petty, Ajeet Gajra, Heidi D Klepin
BACKGROUND: Improved assessment strategies are needed to individualize treatment for adults of all ages receiving palliative chemotherapy for non-small cell lung cancer (NSCLC). Our aim was to evaluate the utility of the Fried Frailty Index (FFI) and a cancer-specific geriatric assessment (GA) to predict chemotherapy toxicity and overall survival (OS). METHODS: We conducted a multi-site pilot study of 50 patients with newly diagnosed advanced NSCLC, age ≥ 18 years...
July 10, 2018: Journal of Geriatric Oncology
Enrique Soto-Perez-de-Celis, Kah Poh Loh
No abstract text is available yet for this article.
July 10, 2018: Journal of Geriatric Oncology
Dorothee Volkert, Anne Marie Beck, Tommy Cederholm, Alfonso Cruz-Jentoft, Sabine Goisser, Lee Hooper, Eva Kiesswetter, Marcello Maggio, Agathe Raynaud-Simon, Cornel C Sieber, Lubos Sobotka, Dieneke van Asselt, Rainer Wirth, Stephan C Bischoff
BACKGROUND: Malnutrition and dehydration are widespread in older people, and obesity is an increasing problem. In clinical practice, it is often unclear which strategies are suitable and effective in counteracting these key health threats. AIM: To provide evidence-based recommendations for clinical nutrition and hydration in older persons in order to prevent and/or treat malnutrition and dehydration. Further, to address whether weight-reducing interventions are appropriate for overweight or obese older persons...
June 18, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Maria Schubert, Roger Schürch, Soenke Boettger, David Garcia Nuñez, Urs Schwarz, Dominique Bettex, Josef Jenewein, Jasmina Bogdanovic, Marina Lynne Staehli, Rebecca Spirig, Alain Rudiger
BACKGROUND: Delirium is a well-known complication in cardiac surgery and intensive care unit (ICU) patients. However, in many other settings its prevalence and clinical consequences are understudied. The aims of this study were: (1) To assess delirium prevalence in a large, diverse cohort of acute care patients classified as either at risk or not at risk for delirium; (2) To compare these two groups according to defined indicators; and (3) To compare delirious with non-delirious patients regarding hospital mortality, ICU and hospital length of stay, nursing hours and cost per case...
July 13, 2018: BMC Health Services Research
Yoji Kokura, Hidetaka Wakabayashi, Shinta Nishioka, Keisuke Maeda
AIM: There is no consensus on energy intake in the acute stage and how it relates to improvement in activities of daily living (ADL) in geriatric stroke patients. We examined whether energy intake after admission is related to improvement in ADL and complications. METHODS: This retrospective cohort study evaluated the data from stroke inpatients at five acute care hospitals, including the mean daily energy intake during the first week after admission. Patients were categorized into two groups based on their daily energy intake; cases where the energy intake per day reached the basal energy expenditure calculated by the Harris-Benedict equation were designated as the intake energy sufficiency group...
July 13, 2018: Geriatrics & Gerontology International
Sophie Moerman, Nina Mc Mathijssen, Wim E Tuinebreijer, Rob Ghh Nelissen, Anne Jh Vochteloo
AIM: A significant loss of instrumental activities of daily living (IADL) after a hip fracture has been reported. The aim of the present study was to identify specific predictors for low IADL after a hip fracture, in order to target better postoperative care for these patients. METHODS: A prospective observational cohort study of 480 hip fracture patients was carried out. IADL was measured at baseline, and after 3 and 12 months using the Groningen Activity Restriction Scale...
July 13, 2018: Geriatrics & Gerontology International
Jana Seele, Michael Kirschfink, Marija Djukic, Peter Lange, Johannes Gossner, Stephanie Bunkowski, Jens Wiltfang, Roland Nau
BACKGROUND: The complement system is a functional link between the innate and adaptive immune system and present in all compartments of the body. The composition of the cerebrospinal fluid (CSF) differs between the ventricular, cisternal and lumbar space. Usually, concentrations of blood-derived CSF proteins increase from ventricular to lumbar fractions. METHODS: In 20 geriatric patients with suspected normal pressure hydrocephalus (NPH) [13 women, 7 men, age 80...
July 9, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Pınar Henden Çam, Ahmet Baydin, Savaş Yürüker, Ali Kemal Erenler, Erdinç Şengüldür
Introduction: The aim of this study is to detect the possible reasons of abdominal pain in the patients aged 65 and older admitted to emergency department (ED) with complaint of abdominal pain which is not related to trauma, to determine the length of hospitalization of old (65-75 age) and elderly (aged 75 and older) patients, and to define the hospitalization and mortality rates. Material and Methods: In the study, 336 patients were included. Groups were compared in respect to gender, internal or surgical prediagnoses, complaints accompanying abdominal pain, vital findings, comorbidities, requested consultations, hospitalizing service, waiting time in the ED and in the hospital, and treatment methods...
2018: Current Gerontology and Geriatrics Research
Ellen E Lee, Lisa T Eyler
No abstract text is available yet for this article.
June 18, 2018: American Journal of Geriatric Psychiatry
Natasha Mirza, Jennifer Y Lee
No abstract text is available yet for this article.
August 2018: Otolaryngologic Clinics of North America
Blas Y Betancourt, Ann Biehl, James D Katz, Ananta Subedi
Providing safe and effective pharmacotherapy to geriatric patients with rheumatologic disorders is challenging. Multidisciplinary care involving rheumatologists, primary care physicians, and other specialties can optimize benefit and reduce adverse outcomes. Oral disease-modifying antirheumatic drugs, including methotrexate, hydroxychloroquine, sulfasalazine, and leflunomide, and the small molecule inhibitors tofacitinib and apremilast have distinctive monitoring requirements and specific adverse reaction profiles...
August 2018: Rheumatic Diseases Clinics of North America
Jean Neils-Strunjas, K Jason Crandall, Jo Shackelford, Kathryn Dispennette, Lauren Rene Stevens, Allison Glascock
The aim of this study was to assess undergraduate students' perceptions of older adults over the semester in an interprofessional service-learning course that implemented a health promotion program called Bingocize® at community facilities for older adults. Students were surveyed at the beginning of the semester, at midterm, and at the conclusion of the course. Quantitative and qualitative data were collected to assess the students' perceptions and experiences. Results suggest that a course on aging that includes interprofessional service-learning in geriatric settings is associated with a significant increase in positive perceptions of the older adult population...
July 12, 2018: Gerontology & Geriatrics Education
Adriana Ávila, Iván De-Rosende-Celeiro, Gabriel Torres, Mirian Vizcaíno, Manuel Peralbo, Montserrat Durán
Nonpharmacologic therapies such as occupational therapy (OT) are promising for people with Alzheimer's disease (AD). However, more research is needed to better understand the effectiveness of home-based OT programs. This pilot study aimed to assess the effects of a home-based, high-intensity and multicomponent OT intervention on the activities of daily living of people with AD in Spain. The secondary objective was to examine its impact on the cognitive functions. A multiple-baseline intrasubject design was used...
July 11, 2018: Health & Social Care in the Community
Yuta Nemoto, Kumiko Nonaka, Masami Hasebe, Takashi Koike, Ushio Minami, Yoh Murayama, Hiroshi Murayama, Hiroko Matsunaga, Taro Fukaya, Erika Kobayashi, Kazushi Maruo, Yoshinori Fujiwara
AIM: Identifying factors that influence participation in social group activities in older adults might be helpful in promoting social participation in this population. We examined factors related to new or continuous participation in social group activities according to group type. METHODS: We carried out a community-based, longitudinal study with a 2-year follow-up period. Of 7608 older adults aged ≥65 years, 3380 completed the follow-up survey and were included in the analysis...
July 12, 2018: Geriatrics & Gerontology International
Elif Atag, Feyza Mutlay, Pinar Soysal, Huseyin S Semiz, Seher N Kazaz, Murat Keser, Hulya Ellidokuz, Aziz Karaoglu
BACKGROUND: Depression is one of the most prevalent causes of distress in the geriatric population. The purpose of this study was to examine the prevalence of depressive symptoms in elderly cancer patients and to determine the possible associated factors. METHODS: Cancer patients 65 years or older and on active chemotherapy completed the Yesavage Geriatric Depression Scale. We examined the relationship of depressive symptoms with age, gender, marital status, educational background, type of cancer, stage of disease, comorbidities, types of treatment for cancer, the duration after diagnosis of cancer, social support, and pain status...
July 11, 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
Hidekazu Nishimura, Ko Sato, Francois Marie Ngako Kadji, Suguru Ohmiya, Hiroko Ito, Toru Kubo, Sho Hashimoto
Reports on respiratory syncytial virus (RSV) infections are abundant in pediatric and geriatric populations but not many in healthy adults, and particularly, those which demonstrated the illness throughout its time course are rare. We report two otherwise-healthy adult cases, showing a number of evidence essential for confirmation of exclusive infections with RSV, and document their clinical features from the onset of the disease to recovery, including secondary sinusitis with magnetic resonance (MR) and computed tomography (CT) images...
May 2018: Journal of Thoracic Disease
Xiang Tang, Meng Xiao, Chao Zhuo, Yingchun Xu, Nanshan Zhong
Background: With the different situation for clinical antibiotic usage and its management in different regions and medical institutions, the antimicrobial resistance varied in different level. However, the epidemiological data of multi-drug resistant (MDR) strains from the department of respiration is limited. Thus, this study aims to investigate the epidemiology of bacteria isolated from inpatients of respiratory departments, and analyze the distribution variation of major multi-drug resistant bacteria in China...
May 2018: Journal of Thoracic Disease
Tran H Tran, Anne Reda
OBJECTIVE: The appropriateness of analgesic administrations based on pain score and medication order in older adults during hospitalization was evaluated. SETTING: As-needed analgesic administrations for geriatric patients on hospitalist general medicine services at a large-university-affiliated medical center from January 1 to March 31, 2015, were included. PRACTICE DESCRIPTION: The hospital is a level one trauma center with more than 500 beds serving an area of more than 500,000 people, 12% of whom are 65 years of age or older...
July 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
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