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Fibroblaster soft tissue mobilization

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https://www.readbyqxmd.com/read/26695438/a-novel-nuclear-src-and-p300-signaling-axis-controls-migratory-and-invasive-behavior-in-pancreatic-cancer
#1
David Paladino, Peibin Yue, Hideki Furuya, Jared Acoba, Charles J Rosser, James Turkson
The presence of Src in the nuclear compartment has been previously reported, although its significance has remained largely unknown. We sought to delineate the functions of the nuclear pool of Src within the context of malignant progression. Active Src is localized within the nuclei of human pancreatic cancer cells and mouse fibroblasts over-expressing c-Src where it is associated with p300. Nuclear Src additionally promotes the tyrosine phosphorylation of p300 in pancreatic cancer Panc-1 cells. Src, together with p300, is associated with the high-mobility group AT-hook (HMGA)2 and SET and MYND domain-containing protein (SMYD)3 gene promoters and regulates their expression in a Src-dependent manner...
February 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/25202108/fibroma-of-tendon-sheath-with-11q-rearrangements
#2
Jun Nishio, Hiroshi Iwasaki, Masaya Nagatomo, Masatoshi Naito
Fibroma of tendon sheath is an uncommon, benign fibroblastic tumor that usually occurs in the upper extremities of young and middle-aged adults. A clonal chromosomal aberration, t(2;11)(q31-32;q12), has been described in one case. We herein present a unique cytogenetic finding of fibroma of tendon sheath arising in the first web space of the right hand of a 38-year-old woman. Physical examination showed a 3.5-cm, firm, mobile, non-tender mass. Magnetic resonance imaging showed a well-defined soft tissue mass with iso- to slightly-low signal intensity relative to skeletal muscle on both T1- and T2-weighted sequences...
September 2014: Anticancer Research
https://www.readbyqxmd.com/read/25113037/desmoplastic-fibroma-of-the-mandible-a-series-of-three-cases-and-review-of-literature
#3
REVIEW
T R Woods, D M Cohen, M N Islam, Y Rawal, I Bhattacharyya
The desmoplastic fibroma (DF) is a rare, fibroblastic lesion of bone that histologically resembles the desmoid tumor of soft tissue. Although classified as benign, it frequently demonstrates aggressive behavior, often causing tooth mobility, extensive bone destruction, and has a moderate to high recurrence rate. We present three cases of DF in the mandible: the first in a 13 year old female involving the mandibular body in the region of teeth #s 27-#28, the second in a 57 year old female with a lesion apical to tooth #30, and the third in a 20-year-old female involving the left posterior mandible...
June 2015: Head and Neck Pathology
https://www.readbyqxmd.com/read/23504494/desmoplastic-fibroblastoma-presenting-as-a-parotid-tumour-a-case-report-and-review-of-the-literature
#4
REVIEW
Vinayak Nagaraja, Hedley G Coleman, Gary J Morgan
Desmoplastic fibroblastomas (DFs) are rare fibrous soft tissue tumours that usually arise in subcutaneous tissue or skeletal muscle in a variety of anatomical sites. These lesions most frequently present as painless, slow-growing mobile masses. A case of DF is described in a 47-year-old man who presented with a painless right parotid mass of 2 months duration. At surgery, the lesion was attached to the tail of the right parotid gland. Histopathological examination demonstrated a fibrous lesion comprising spindled and stellate shaped fibroblasts with focal myxoid stromal change...
September 2013: Head and Neck Pathology
https://www.readbyqxmd.com/read/22140669/the-effects-of-enamel-matrix-derivative-and-cyclic-mechanical-strain-on-human-gingival-fibroblasts-in-an-in-vitro-defect-healing-model
#5
COMPARATIVE STUDY
Jill E Sanders, Augustine Chuang, Gary D Swiec, Fredrick C Bisch, Robert W Herold, Thomas B Buxton, James C McPherson
Gingival fibroblasts (GFs) play a considerable role in the maintenance of the gingival apparatus as well as in connective tissue repair. Mobility of a periodontal wound or soft tissue graft can impair connective tissue healing from the GFs. Enamel matrix derivative (EMD) is an enamel matrix protein used clinically for periodontal regeneration of intrabony defects and furcations, as well as treatment of gingival margin recessions. The goal of this project was to compare the effects of varying concentrations of EMD, with and without cyclic mechanical strain, on cellular wound fill of human GFs using an in vitro defect healing model...
November 2011: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/21333928/ischemic-fasciitis-in-an-85-year-old-debilitated-female
#6
Lilian N Oguejiofor, Inna Sheyner, Karen T Stover, Vladimir Osipov
Ischemic fasciitis is a rare reactive, non-neoplastic proliferation of atypical fibroblasts typically seen in older debilitated patients at pressure points. We describe the case of an 85-year-old female nursing home resident with a past medical history of advanced dementia and immobility who developed an enlarging nodule on the posterior aspect of her right shoulder. A needle biopsy was performed under ultrasound guidance, and the histology was consistent with ischemic fasciitis. Surgical resection of the lesion was performed and anatomical pathology was consistent with ischemic fasciitis...
March 2011: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/20596989/collagenous-fibroma-desmoplastic-fibroblastoma-of-the-neck-presenting-with-neurological-symptoms
#7
Farina Fong, Edward Odell, Ricard Simo
Collagenous fibromas are rare fibrous soft tissue tumours that usually arise in subcutaneous tissue or skeletal muscle at a variety of anatomical sites. These lesions commonly present as painless, slow-growing mobile masses. We describe a unique case of a 41-year-old woman presenting with a posterior neck swelling and longstanding history of severe ongoing pain in the right scapular region, shoulder and neck, weakness of the palmar grip and limited right lateral neck flexion and rotation. A history of trauma to the right neck in adolescence was noted...
March 2009: Head and Neck Pathology
https://www.readbyqxmd.com/read/19738495/a-rare-case-of-infantile-myofibromatosis-and-review-of-literature
#8
REVIEW
Peter A Hausbrandt, Andreas Leithner, Alfred Beham, Koppany Bodo, Johannes Raith, Reinhard Windhager
Infantile myofibromatosis is a rare benign tumor-disease (1/400,000). Four different types have been reported in literature. The most commonly affected body areas are the head, the neck, and the trunk. We would like to present a rare case of a multicentric type with singular visceral involvement and a literature review of all case series with more than five patients. A 9-month-old boy presented with a swelling on the medial side of his proximal left tibia. The lesion which was present since birth, was well palpable, indolent, hard, and mobile in relation to the surrounding tissue...
January 2010: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/18724246/ischemic-fasciitis-analysis-of-44-cases-indicating-an-inconsistent-association-with-immobility-or-debilitation
#9
Bernadette Liegl, Christopher D M Fletcher
Ischemic fasciitis is a rare pseudosarcomatous proliferation of atypical fibroblasts described to be located over bony protuberances and said to develop most often in immobile elderly or debilitated patients. We report the clinicopathologic features of 44 cases of this pseudosarcomatous reactive fibroblastic/myofibroblastic proliferation. There were 15 female and 29 male patients between 23 and 96 years of age (median: 74 y). Tumor size, known in 34 cases, ranged from 1.3 to 10 cm (median: 4.7 cm). The lesions developed mostly in the deep subcutis (27 cases) and infiltration of deep dermis, muscle, and tendinous tissue was sometimes observed...
October 2008: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/18499994/cytologic-diagnosis-of-fibrous-hamartoma-of-infancy-a-case-report-of-a-rare-soft-tissue-lesion
#10
Ruchika Gupta, Sompal Singh
BACKGROUND: Fibrous hamartoma of infancy (FHI) is a rare, benign lesion seen in the first 2 years of life. Despite adequate histopathologic descriptions, reports of it in the cytology literature are rare. CASE: A 6-month-old male infant presented with an asymptomatic nodule in left anterior axillary fold. The nodule was noticed 6 weeks before presentation. On local examination, it was mobile and rubbery. Considering the endemicity, a presumptive clinical diagnosis of tuberculous lymphadenitis was made...
March 2008: Acta Cytologica
https://www.readbyqxmd.com/read/17467696/load-application-induces-changes-in-the-expression-levels-of-sox-9-fgfr-3-and-vegf-in-condylar-chondrocytes
#11
Alexandra K Papadopoulou, Dionysios J Papachristou, Stavros A Chatzopoulos, Pertti Pirttiniemi, Athanasios G Papavassiliou, Efthimia K Basdra
Experimental and clinical observations have proven the modulatory effects of mechanical loading on the development and maintenance of cartilage architecture. Here we examined the involvement of Sox-9, FGFR-3 and VEGF (pivotal factors controlling cartilage development and growth) in the mechano-transduction pathway of mandibular condylar cartilage by changing the dynamics of the transmitted load via changes in food hardness. To this end, condyle cartilage tissue of rats fed with hard or soft food was analyzed immunohistochemically at various time points...
May 15, 2007: FEBS Letters
https://www.readbyqxmd.com/read/16717057/fusion-between-cic-and-dux4-up-regulates-pea3-family-genes-in-ewing-like-sarcomas-with-t-4-19-q35-q13-translocation
#12
Miho Kawamura-Saito, Yukari Yamazaki, Keiko Kaneko, Noriyoshi Kawaguchi, Hiroaki Kanda, Hiroyuki Mukai, Takahiro Gotoh, Tohru Motoi, Masashi Fukayama, Hiroyuki Aburatani, Toichiro Takizawa, Takuro Nakamura
Ewing's family tumors (EFTs) are highly malignant tumors arising from bone and soft tissues that exhibit EWS-FLI1 or variant EWS-ETS gene fusions in more than 85% of the cases. Here we show that CIC, a human homolog of Drosophila capicua which encodes a high mobility group box transcription factor, is fused to a double homeodomain gene DUX4 as a result of a recurrent chromosomal translocation t(4;19)(q35;q13). This translocation was seen in two cases of soft tissue sarcoma diagnosed as Ewing-like sarcoma. CIC-DUX4 exhibits a transforming potential for NIH 3T3 fibroblasts, and as a consequence of fusion with a C-terminal fragment of DUX4, CIC acquires an enhanced transcriptional activity, suggesting that expression of its downstream targets might be deregulated...
July 1, 2006: Human Molecular Genetics
https://www.readbyqxmd.com/read/12724936/morphological-evaluation-of-mrc-5-fibroblasts-after-stimulation-with-static-magnetic-field-and-pulsating-electromagnetic-field
#13
COMPARATIVE STUDY
Kimberly Pate, Ham Benghuzzi, Michelle Tucci, Aaron Puckett, Zelma Cason
The quality of tissue repair and the speed with which that repair can be accomplished are the two major variables in the healing of any injury. Today, magnetic field exposure to traumatized areas has shown to be a promising tool in the healing process. The exact mode of action by which radiating and unchanging magnetic fields still has to be elucidated. The objective of this study was to evaluate the morphology of MRC-5 fibro-blasts after stimulation with static and pulsating magnetic fields. Under sterile environment, a total of 24 wells were loaded with 50,000 MRC-5 cells each and further divided into three groups...
2003: Biomedical Sciences Instrumentation
https://www.readbyqxmd.com/read/10211847/fibroblast-responses-to-variation-in-soft-tissue-mobilization-pressure
#14
G M Gehlsen, L R Ganion, R Helfst
UNLABELLED: Augmented soft tissue mobilization therapy (ASTM), a newly developed massage therapy, has been successfully used in the treatment of chronic tendinitis patients. We theorized that the ASTM technique promotes healing through a controlled application of microtrauma. PURPOSE: The purpose of this study was to determine morphologic changes in the rat Achilles tendon after enzyme-induced injury with collagenase and subsequent pressure variations in ASTM therapy...
April 1999: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/9610889/characterization-of-cementum-derived-growth-factor-as-an-insulin-like-growth-factor-i-like-molecule
#15
K Ikezawa, C E Hart, D C Williams, A S Narayanan
Cementum is the thin calcified outer layer through which tooth-root surfaces are anchored to soft periodontal connective tissues. A variety of growth factors and adhesion molecules are sequestered in the extracellular matrix of cementum, and we have purified and characterized one of the growth factors. This growth factor, the cementum derived growth factor (CGF), was purified from bovine cementum by acetic acid extraction followed by heparin affinity chromatography and HPLC using cation exchange, molecular sieve, and reverse-phase columns...
1997: Connective Tissue Research
https://www.readbyqxmd.com/read/9443147/effects-of-nd-yag-laser-irradiation-on-monolayer-cell-cultures
#16
COMPARATIVE STUDY
N Gutknecht, S Kanehl, A Moritz, C Mittermayer, F Lampert
BACKGROUND AND OBJECTIVE: The clinical applications of Nd:YAG lasers on oral soft tissues include a wide field of surgical and periodontal procedures. This in vitro study focuses on the histological effects of Nd:YAG-laser irradiation on a fibroblast monolayer cell culture especially with regard to thermal damage and cell necrosis. The results of this basic research study provide us with clear power settings for a safe soft tissue laser treatment. STUDY DESIGN/MATERIALS AND METHODS: Two hundred forty multiwell cell cultures and 24 micro-slide Leighton tubes were laser treated...
1998: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/9309143/-dan-gene
#17
REVIEW
S Sakiyama, T Ozaki
DAN gene has been isolated by means of differential screening method between rat fibroblast 3Y1 and Rous sarcoma virus-transformed 3Y1 (SR-Y1) cells. DAN expression was suppressed in some of the transformed cells and its re-expression reverted the various transformed phenotypes such as colony formation in soft agar and tumor formation in mice. When DAN was overexpressed in 3Y1 cells, these cell showed the retardation of the entry into the S phase. DAN cDNA encodes a 27-kD protein which consists of 178 amino acids...
September 1997: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/9139169/rat-tendon-morphologic-and-functional-changes-resulting-from-soft-tissue-mobilization
#18
C J Davidson, L R Ganion, G M Gehlsen, B Verhoestra, J E Roepke, T L Sevier
Augmented Soft Tissue Mobilization (ASTM) is a new non-invasive soft tissue mobilization technique which has been used successfully to treat a variety of musculoskeletal disorders. The purpose of this study was to determine the effects of ASTM therapy on the morphological and functional characteristics of enzyme induced injured rat Achilles tendons. Four groups of five rats were allocated as follows: (A) control, (B) tendinitis, (C) tendinitis plus ASTM, and (D) ASTM alone. Collagenase injury was induced, and the surgical site was allowed to heal for 3 wk...
March 1997: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/7929857/tooth-mobility-and-resolution-of-experimental-periodontitis-an-experimental-study-in-the-dog
#19
M Giargia, I Ericsson, J Lindhe, T Berglundh, A M Neiderud
The aim of the present experiment was to study alterations in the mobility of teeth that occurred during resolution of experimentally induced periodontitis lesions in the dog. 5, 1-year-old, beagle dogs were used in the study. The left and right 4th, 3rd, and 2nd mandibular premolars (4P4, 3P3, 2P2) served as experimental teeth. Periodontal tissue breakdown was initiated by placing plaque-collecting cotton-floss ligatures around the neck of the experimental teeth. The ligatures were replaced to the level of the receding gingival margin 1 x every month...
August 1994: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/7550946/volkmann-s-ischemic-contracture-of-the-foot-and-ankle-evaluation-and-treatment-of-established-deformity
#20
REVIEW
M D Santi, M J Botte
Fibrotic contracture of skeletal muscle can follow weeks or months after the severe ischemic insult of compartment syndrome. Commonly known as Volkmann's ischemic contracture, the affected limb often becomes dysfunctional and painful, and may lose sensibility. The pathogenesis of the muscle contracture includes prolonged ischemia, myonecrosis, fibroblastic proliferation, contraction of the cicatrix, and myotendinous adhesion formation. Resultant shortening or overpull of involved muscles leads to stiffness and deformity...
June 1995: Foot & Ankle International
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