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Idiopathic choroidal polypoidal vasculopathy

Ambreen Sarmad, Fadi Alfaqawi, Monali Chakrabarti, Samer Elsherbiny
Purpose: This rare case shows the presence of both angioid streaks (AS) and central serous chorioretinopathy (CSC) in the same eye. Methods: A 41-year-old Caucasian male who also has a positive family history of AS was diagnosed with angioid streaks. He was followed for few years, later developed CSC in his good eye. Results: Fundus fluorescein led to the diagnosis of CSC and indocyanine green angiography ruled out the possibility of idiopathic polypoidal choroidal vasculopathy (IPCV). The CSC followed a chronic course of non-resolution and finally half fluence photodynamic therapy was performed...
2018: GMS Ophthalmology Cases
James G Wong, Katherine Yu Qian
PURPOSE: Angioid streaks (AS) are dehiscences in Bruch's membrane that may be idiopathic or associated with numerous systemic illnesses. Polypoidal choroidal vasculopathy (PCV) is an underdiagnosed exudative chorioretinopathy often characterised by serosanguineous detachments of the pigmented epithelium. The use of the anti-VEGF agents ranibizumab and aflibercept in the management of PCV secondary to AS has not been previously documented. We report 3 patients with active PCV secondary to AS, 1 of which had a family history of PCV secondary to AS, not previously reported in the literature...
January 2017: Case Reports in Ophthalmology
D Sandner
Choroidal neovascularisation (CNV) in the context of exsudative age-related macular degeneration (nAMD) can be divided into type 1 (occult) and type 2 (classical) membranes. Retinal angiomatous proliferation (RAP) or polypoidal choroidal vasculopathy (PCV) are "rare subtypes" of chorioretinal neovascularisation and are distinguished by their distinct morphology and the sometimes worse response to therapy. Chorioretinal anastomosis, severe exsudates with serosanguinous pigment epithelial detachment and, in PCV, orange-red lesions in the papillomacular bundle can be diagnostic...
March 10, 2017: Klinische Monatsblätter Für Augenheilkunde
Chavakij Bhoomibunchoo, Yosanan Yospaiboon, Somanus Thoongsuwan, Duangnate Rojanaporn, Nawat Watanachai, Pichai Jirarattanasopa, Nattapon Wongcumchang, Atchara Amphornphruet, Sritatath Vongkulsiri, Eakkachai Arayangkoon
OBJECTIVE: This study aimed to study the prevalence and characteristics of idiopathic polypoidal choroidal vasculopathy (IPCV) in Thai patients with clinical and angiographic choroidal neovascularization (CNV). PATIENTS AND METHODS: A consecutive case study of 140 patients presenting with CNV was conducted in nine large referral eye centers throughout Thailand. The demographic data, fundus photographs, fundus fluorescein angiography and indocyanine green angiography of the patients were analyzed...
2017: Clinical Ophthalmology
Jay Chhablani, Chintan Jethalal Dedhia, Hari K Peguda, Michael Stewart
PURPOSE: To evaluate the safety of single intravitreal 2 mg ziv-aflibercept (0.08 mL) injections for the treatment of choroidal neovascular membranes (CNVM). METHODS: Eyes with choroidal neovascular membranes because of several conditions each received single intravitreal injections of 2 mg ziv-aflibercept (0.08 mL). Comprehensive ophthalmic examinations and detailed systemic evaluations were performed at baseline and Days 1, 7, and 30 after injections. Standard electroretinography was performed at baseline and Day 30...
October 2017: Retina
Parveen Sen, S Vinay Kumar, Muna Bhende, Tarun Sharma
AIM: To evaluate the efficacy of combination therapy of argon laser photocoagulation and intravitreal antivascular endothelial growth factor (VEGF) injection in idiopathic polypoidal choroidal vasculopathy (PCV) involving macula. MATERIALS AND METHODS: A retrospective interventional study involving 12 eyes of 11 patients diagnosed with PCV involving the macula on indocyanine green angiography (ICGA). Intravitreal anti-VEGF was given in eyes with significant subretinal/sub retinal pigment epithelium hemorrhage or exudation...
September 2016: Oman Journal of Ophthalmology
Seongyong Jeong, Min Sagong
BACKGROUND/AIMS: To compare the short-term efficacy of intravitreal aflibercept treatment according to the subtypes of polypoidal choroidal vasculopathy (PCV) based on indocyanine green angiography (ICGA). METHODS: Twenty-nine patients (29 eyes) with treatment-naïve subfoveal PCV were consecutively enrolled in this institutional study. The subjects were classified into two subtypes (type 1, polypoidal choroidal neovascularisation (CNV), 16 eyes; and type 2, idiopathic PCV, 13 eyes) based on the presence or absence of both feeder and draining vessels on ICGA...
June 2017: British Journal of Ophthalmology
Aristomenis Thanos, John B Miller, Kelly N Ma, Manju L Subramanian, Ivana K Kim, Dean Eliott
The authors report a new variant of idiopathic polypoidal choroidal vasculopathy (IPCV) in middle-aged Haitian men characterized by extramacular polypoidal lesions and bilateral extensive pigmentary alterations in the posterior pole in an annular wreath-like pattern surrounding the optic nerve and macular area. Two patients were seen at Massachusetts Eye and Ear Infirmary and one at Boston University Medical Center between 2010 and 2015. All three patients were middle-aged Haitian men who exhibited bilateral features of IPCV, including subretinal hemorrhages and serosanguinous pigment epithelial detachments...
April 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
Mayer Srour, Giuseppe Querques, Eric H Souied
PURPOSE: To analyze the morphological characteristics of polypoidal choroidal vasculopathy (PCV) on optical coherence tomography angiography (OCT-A). METHODS: Consecutive patients with PCV underwent complete ophthalmological examination, including fundus photography, fluorescein angiography, indocyanine green angiography, spectral-domain OCT and OCT-A. RESULTS: Segmentation of the choriocapillaris layer on OCT-A revealed the branching vascular network as a hyper-flow lesion, and it revealed the polypoidal lesion as a hyper-flow round structure surrounded by a hypo-intense halo in some cases and as a hypo-flow round structure in most cases...
2016: Developments in Ophthalmology
Aditya Sudhalkar, Divya Balakrishnan, Subhadra Jalali, Raja Narayanan
PURPOSE: To determine the role of systemic steroids in improving visual acuity, preventing recurrence and hastening pigment epithelial detachment resolution in IPCV patients. METHODS: Retrospective computer assisted comparative case series of consecutive patients with documented IPCV who did and did not receive systemic steroids as part of their treatment regimen between 2007 and 2012. Patients who had systemic contraindication to steroid therapy were excluded from the steroid arm...
January 2016: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
Nora W Muakkassa, Adam T Chin, Talisa de Carlo, Kendra A Klein, Caroline R Baumal, Andre J Witkin, Jay S Duker, Nadia K Waheed
PURPOSE: To use optical coherence tomography angiography (OCTA) to characterize the effects of anti-VEGF injections on treatment-naive choroidal neovascularization (CNV). METHODS: From August 2014 to May 2015, treatment-naive eyes with CNV were scanned using a prototype OCTA system on a commercially available SD-OCT device (Optovue Inc, Fremont, CA). Optical coherence tomography angiography scans were obtained before anti-VEGF injection and at follow-up visits. The CNV area and greatest linear dimension (GLD) were measured along with the maximum retinal pigment epithelial detachment (RPED) height...
November 2015: Retina
Rony Carlos Preti, Mario Luiz Ribeiro Monteiro, Celso Morita, John Helal Junior, Leandro Cabral Zacharias, Daniel Araújo Ferraz, David E Pelayes, Walter Yukihiko Takahashi
This case report describes peripheral idiopathic polypoidal choroidal vasculopathy (IPCV) with a collection of small aneurysmal dilations that masqueraded as choroidal tumors in an elderly patient. A 68-year-old African American woman was referred to us with a suspected diagnosis of asymptomatic vascular choroidal tumor and choroidal capillary hemangioma, affecting the temporal peripheral fundus. Upon examination, optical coherence tomography (OCT) revealed two large hemorrhagic pigment epithelium detachments (PED), and indocyanine green angiography (ICG) confirmed the diagnosis of IPCV...
May 2015: Arquivos Brasileiros de Oftalmologia
Dinu Stanescu-Segall, Florian Balta, Timothy L Jackson
Large submacular hemorrhage, an uncommon manifestation of neovascular age-related macular degeneration, may also occur with idiopathic polypoidal choroidal vasculopathy. Submacular hemorrhage damages photoreceptors owing to iron toxicity, fibrin meshwork contraction, and reduced nutrient flux, with subsequent macular scarring. Clinical and experimental studies support prompt treatment, as tissue damage can occur within 24 hours. Without treatment the natural history is poor, with a mean final visual acuity (VA) of 20/1600...
January 2016: Survey of Ophthalmology
Jordi Monés, Josep Badal, Marc Biarnés
PURPOSE: To describe the management of a subfoveal polypoidal choroidal vasculopathy case refractory to antiangiogenic treatment and to photodynamic therapy. METHODS: Case report. A 65-year-old male patient presented with a diagnosis of exudative age-related macular degeneration of his left eye and unsuccessful response to eight antiangiogenic injections. Visual acuity was 20/33. Fluorescein angiography, spectral domain optical coherence tomography, and indocyanine green angiography confirmed the diagnosis of polypoidal choroidal vasculopathy...
2016: Retinal Cases & Brief Reports
Mitsuko Yuzawa
No abstract text is available yet for this article.
June 2015: Investigative Ophthalmology & Visual Science
Gabriel Coscas, Marco Lupidi, Florence Coscas, Fayçal Benjelloun, Jennifer Zerbib, Ali Dirani, Oudy Semoun, Eric H Souied
PURPOSE: To suggest a clinical distinction between idiopathic polypoidal choroidal vasculopathy (PCV) and secondary polyps associated with neovascular age-related macular degeneration (NV-AMD). METHODS: The study was a retrospective case series of 52 eyes of 52 consecutive patients (31 females and 21 males) diagnosed with PCV. Initial diagnosis was based on scanning laser ophthalmoscope-indocyanine green angiography (SLO-ICGA) in association with fluorescein angiography (FA) and optical coherence tomography (OCT)...
May 2015: Investigative Ophthalmology & Visual Science
Min Zhao, Yujing Bai, Wankun Xie, Xuan Shi, Fangting Li, Fei Yang, Yaoyao Sun, Lvzhen Huang, Xiaoxin Li
PURPOSE: To examine the expression of pro-interleukin-1β (pro-IL-1β) and interleukin-1β (IL-1β) in the vitreous body of patients with neovascular age-related macular degeneration(nAMD), polypoidal choroidal vasculopathy (PCV), proliferative diabetic retinopathy (PDR), retinal vein occlusion (RVO) or Eales' disease to further elucidate the role of IL-1β and inflammation in the pathogenesis of neovascular retinal disease. DESIGN: Prospective clinical laboratory investigation study...
2015: PloS One
Suthasinee Sinawat, Chavakij Bhoomibunchoo, Yosanan Yospaiboon, Supat Sinawat
Retinalpigment epithelium (RPE) rips commonly occur in retinochoroidal disorders including age-related macular degeneration, idiopathic polypoid alchoroidal vasculopathy, central serous chorioretinopathy, high myopia andchoroidal neovascularization. Most patients have unilateral involvement and poor visual prognosis. A 55-year-old female presented with decreased vision in her right eye for one week. Her best-corrected visual acuity was 6/12 in the right eye and 6/6-2 in the left. Fundus examination revealed a large juxtafoveal RPE rip in the right eye and multiple small pigment epithelium detachments in the left...
October 2014: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Oluleye T S, Babalola Y
BACKGROUND: Angiogenesis is a contributing factor in some retinal diseases, hence the role of vascular endothelial growth factor (VEGF) as a common pathway in proliferative retinopathies. Bevacizumab has been found to be effective in the treatment of these diseases. The aim of this study was to review all cases of intravitreal bevacizumab given in the retinal unit of the University College Hospital, Ibadan from July, 2010 to June 2012, pointing out the common indications. METHODS: After obtaining ethical approval from the University College Hospital/University of Ibadan Review Board for the study, all cases of intravitreal injections of bevacizumab recorded in the retinal register during the study period (July 2010 to June 2012) were retrieved...
2014: Open Ophthalmology Journal
Daniel Vilaplana, Vladimir Poposki, Daniel Martín, Ana Martínez-Palmer, Miguel Castilla
PURPOSE: To evaluate the efficacy of photodynamic therapy (PDT) in a patient with juxtapapillary idiopathic polypoidal choroidal vasculopathy (IPCV) in the papillomacular bundle. METHODS: One session of PDT using a spot size with diameter of 1000 μm in the center of the juxtapapillary lesion was applied. PATIENT: A 75-year-old woman with decreased vision (20/80) in her right eye over a period of 1 year. RESULTS: After a follow-up of 2 years, the best-corrected visual acuity was 20/32, the lesion remained sclerosed, and lipids have disappeared...
2008: Retinal Cases & Brief Reports
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