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Pigment epithelial detachment

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https://www.readbyqxmd.com/read/29778134/central-serous-chorioretinopathy-in-african-americans-at-wilmer-eye-institute
#1
Pooja H Mehta, Jay Chhablani, Jiangxia Wang, Catherine B Meyerle
OBJECTIVE: To evaluate the frequency of central serous chorioretinopathy (CSC) in African Americans/blacks within an academic center in a predominantly African American city, as the current belief is that CSC is rare in this population. METHODS: A retrospective review of all patients' charts diagnosed with CSC at Wilmer Eye Institute/Johns Hopkins University from August 2009-August 2015 was conducted via an electronic health record search (EPIC). The charts were categorized by self-reported race and gender...
June 2018: Journal of the National Medical Association
https://www.readbyqxmd.com/read/29769188/sturge-weber-syndrome-associated-glaucoma-and-intraocular-osseous-metaplasia-a-unique-complicated-case
#2
Dmytro Pavlenko, Tetiana Scovpen, Oksana Vitovska
A 30-year-old European man was admitted to our centre complaining about severe pain of the right eye (OD) and right part of the face, redness and no vision of the OD. He had an 18-year history of secondary to Sturge-Weber syndrome glaucoma, 6-month history of red eye and 1-week history of pain in OD. The best-corrected visual acuity was no light perception OD and 20/20 OS. Intraocular pressure was 36 mm Hg OD. Examination revealed endophthalmitis, Sturge-Weber syndrome-associated glaucoma and complicated cataract of OD...
May 16, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29722151/specifying-neural-crest-cells-from-chromatin-to-morphogens-and-factors-in-between
#3
REVIEW
Crystal D Rogers, Shuyi Nie
Neural crest (NC) cells are a stem-like multipotent population of progenitor cells that are present in vertebrate embryos, traveling to various regions in the developing organism. Known as the "fourth germ layer", these cells originate in the ectoderm between the neural plate (NP), which will become the brain and spinal cord, and nonneural tissues that will become the skin and the sensory organs. NC cells can differentiate into more than 30 different derivatives in response to the appropriate signals including, but not limited to, craniofacial bone and cartilage, sensory nerves and ganglia, pigment cells, and connective tissue...
May 3, 2018: Wiley Interdisciplinary Reviews. Developmental Biology
https://www.readbyqxmd.com/read/29698960/protective-effects-of-fucoidan-on-epithelial-mesenchymal-transition-of-retinal-pigment-epithelial-cells-and-progression-of-proliferative-vitreoretinopathy
#4
Yao Zhang, Dongwan Zhao, Shuai Yang, Haipei Yao, Min Li, Chun Zhao, Jingfa Zhang, Guo-Tong Xu, Hui Li, Fang Wang
BACKGROUND/AIMS: Proliferative vitreoretinopathy (PVR) is a severe blinding complication of rhegmatogenous retinal detachment. Epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells is thought to play a pivotal role in the pathogenesis of PVR. Fucoidan, a marine extract, reportedly has many benefits effects in a variety of tissues and organs such as anti-inflammation, anti-oxidative stress, and anti-carcinogenesis. In this study, we investigated the potential role of fucoidan on EMT in RPE cells and its effect on the development of PVR...
April 23, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29697591/optimal-management-of-pigment-epithelial-detachments-in-eyes-with-neovascular-age-related-macular-degeneration
#5
Arshad M Khanani, David Eichenbaum, Patricio G Schlottmann, Lisa Tuomi, David Sarraf
PURPOSE: This review aimed to determine the optimal management of retinal pigment epithelial detachments (PEDs) in neovascular age-related macular degeneration (nAMD) based on review of available evidence in the literature. METHODS: A comprehensive literature review evaluates previous retrospective and prospective studies that assessed the treatment of PEDs in nAMD. RESULTS: Studies illustrated that anti-vascular endothelial growth factor (VEGF) therapy can be effective in eyes with PED secondary to nAMD...
April 24, 2018: Retina
https://www.readbyqxmd.com/read/29689028/detection-of-type-1-choroidal-neovascular-membranes-using-optical-coherence-tomography-angiography-in-tubercular-posterior-uveitis
#6
Kanika Aggarwal, Aniruddha Agarwal, Aman Sharma, Kusum Sharma, Vishali Gupta
PURPOSE: To study optical coherence tomography angiography (OCTA) and multimodal imaging features of Type 1 inflammatory choroidal neovascularization (CNV) in tubercular serpiginous-like choroiditis and response to anti-vascular endothelial growth factor therapy. METHODS: In this study, multimodal imaging was performed using OCTA, enhanced-depth imaging optical coherence tomography, fluorescein angiography, and indocyanine green angiography. Correlation of OCTA with other imaging modalities in the detection of CNV was performed...
April 23, 2018: Retina
https://www.readbyqxmd.com/read/29675279/bilateral-diffuse-and-cluster-pigment-epithelial-detachment-associated-with-diffuse-proliferative-glomerulonephritis
#7
Heshmatollah Ghanbari, Alireza Dehghani, Mohsen Pourazizi
Retinal pigment epithelium detachment (PED) is an area of retinal pigment epithelium (RPE) elevation with minimal or no sensory retinal detachment resulting from the accumulation of sub-RPE fluid. There are many etiological factors that lead to the development of PED. PED may be observed as an isolated finding or in association with ocular and systemic conditions. In this case we report a 23-year-old male with bilateral cluster PED associated with diffuse proliferative glomerulonephritis (DPGN). The importance of current report is that development of PED and DPGN is more than a simple incidental event...
2018: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/29655643/automated-segmentation-of-lesions-including-subretinal-hyperreflective-material-in-neovascular-age-related-macular-degeneration
#8
Hyungwoo Lee, Kyung Eun Kang, Hyewon Chung, Hyung Chan Kim
PURPOSE: To evaluate an automated segmentation algorithm with a convolutional neural network (CNN) to quantify and detect intraretinal fluid (IRF), subretinal fluid (SRF), pigment epithelial detachment (PED), and subretinal hyperreflective material (SHRM) through analyses of spectral domain optical coherence tomography (SD-OCT) images from patients with neovascular age-related macular degeneration (nAMD). DESIGN: Reliability and validity analysis of a diagnostic tool...
April 12, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29619248/retinal-and-choroidal-changes-in-steroid-associated-central-serous-chorioretinopathy
#9
Vikas Ambiya, Abhilash Goud, Mohammed Abdul Rasheed, Sankeert Gangakhedkar, Kiran Kumar Vupparaboina, Jay Chhablani
Background: To evaluate the retinal and choroidal alterations in steroid-associated central serous chorioretinopathy (CSC) in comparison to idiopathic CSC. Methods: In this retrospective cohort study, swept source optical coherence tomography scans of eyes with steroid-associated CSC (group A) were compared with the same in idiopathic CSC (group B). The key features included central subfield retinal thickness, subfoveal choroidal thickness, subfoveal large choroidal vessel diameter, subretinal deposits, retinal pigment epithelial irregularities, double layer sign, hyperreflective dots, intraretinal fluid, and choroidal vascularity index (ratio of choroidal luminal area and total choroidal area, measured on a high definition horizontal 9 mm OCT B-scan...
2018: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/29578200/epigallocatechin-gallate-curcumin-prevent-transforming-growth-factor-beta-1-induced-epithelial-to-mesenchymal-transition-in-arpe-19-cells
#10
Sivasankar Shanmuganathan, Venil N Sumantran, Narayanasamy Angayarkanni
Background & objectives: Proliferative vitreoretinopathy (PVR) is characterized by the presence of epiretinal membrane (ERM), which exerts traction and detaches the retina. Epithelial to mesenchymal transition (EMT) of the retinal pigment epithelial (RPE) cells underlies ERM formation. Adjuvant therapies aimed at preventing recurrence of PVR after surgery mostly failed in clinical trials. This study was aimed to evaluate the anti-EMT properties of bio-active compounds epigallocatechin gallate (EGCG), curcumin and lycopene as inhibitors of EMT induced by transforming growth factor beta 1 (TGF-β1) in cultured ARPE-19 cells...
November 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29577101/management-of-recalcitrant-polypoidal-choroidal-vasculopathy-by-feeder-vessel-laser-photocoagulation
#11
Jay Sheth, Giridhar Anantharaman, Shruti Chandra, Mahesh Gopalakrishnan
Purpose: To describe management of residual branch vascular network (BVN) in polypoidal choroidal vasculopathy (PCV) by thermal laser photocoagulation of feeder vessel. Observations: Case report of sixty-four year old female with polypoidal choroidal vaculopathy (PCV) with moderate response to seven doses of intravitreal ranibizumab, six doses of intravitreal bevacizumab and one session of photodynamic therapy (PDT). The patient has resolved polyps but persistence of disease activity due to residual BVN and large pigment epithelial detachment (PED)...
March 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29575941/treatment-outcomes-of-conventional-or-high-dose-ranibizumab-for-vascularized-pigment-epithelial-detachment-based-on-lesion-subtypes
#12
Clement K Chan, David Sarraf, Prema Abraham
INTRODUCTION: A post hoc study was conducted to compare visual and anatomic outcomes of vascularized serous pigment epithelial detachment (Group 1) with fibrovascular pigment epithelial detachment (Group 2) due to age-related macular degeneration treated with either 0.5 or 2.0 mg ranibizumab injections. METHODS: A prospective, randomized trial was performed with the following regimens for 12 months: (1) 0.5 mg monthly, (2) 0.5 mg monthly for 4 months followed by pro re nata injections, (3) 2...
February 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29569087/reversal-of-retinal-pigment-epithelial-detachment-after-cessation-of-topical-travoprost-therapy
#13
Venkataramana Kalikivayi, Jerry Joseph, Blessy Thankom Mathews, Rajkumar Maheswari, Satyajit Mulanjur Vadakara, Sajeev Cherian Jacob
PURPOSE: To report the rare incidence of retinal pigment epithelial detachment (RPED) followed by topical travoprost therapy and its subsequent reattachment after cessation of the drug. METHODS: A 60-year-old male presented with gradual loss of vision in both eyes and distorted images in right eye. He gave a history of visiting an ophthalmologist a week ago for a routine eye examination. His previous reports revealed best-corrected visual acuity (BCVA) of 6/6, N6 in both eyes with raised intraocular pressures...
March 22, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29554052/presentation-of-central-serous-chorioretinopathy-in-two-husband-and-wife-couples
#14
Aditya Kanesa-Thasan, Amani A Fawzi, Manjot K Gill
PURPOSE: Central serous chorioretinopathy (CSC) is a disease in which serous detachment of the neurosensory retina occurs over an area of leakage from the choriocapillaris through the retinal pigment epithelium. Associations have been drawn between high-stress personality types and steroid exposure. This article aims to describe a unique case series of two husband and wife couples with CSC. METHODS: All methods were approved by the authors' institution's institutional review board...
April 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29522718/knockdown-of-survivin-results-in-inhibition-of-epithelial-to-mesenchymal-transition-in-retinal-pigment-epithelial-cells-by-attenuating-the-tgf%C3%AE-pathway
#15
Peng Zhang, Guannan Zhao, Liang Ji, Jinggang Yin, Lu Lu, Wei Li, Guomin Zhou, Edward Chaum, Junming Yue
Proliferative vitreoretinopathy (PVR) is a common complication of open globe injury and the most common cause of failed retinal detachment surgery. The response by retinal pigment epithelial (RPE) cells liberated into the vitreous includes proliferation and migration; most importantly, epithelial to mesenchymal transition (EMT) of RPE plays a central role in the development and progress of PVR. For the first time, we show that knockdown of BIRC5, a member of the inhibitor of apoptosis protein family, using either lentiviral vector based CRISPR/Cas9 nickase gene editing or inhibition of survivin using the small-molecule inhibitor YM155, results in the suppression of EMT in RPE cells...
April 6, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29517581/photodynamic-therapy-for-symptomatic-subfoveal-retinal-pigment-epithelial-detachment-in-central-serous-chorioretinopathy-outcomes-and-prognostic-factors
#16
Sungsoon Hwang, Se Woong Kang, Sang Jin Kim, Jun Won Jang, Kyung Tae Kim
PURPOSE: To report the clinical outcomes of reduced-fluence photodynamic therapy (PDT) for symptomatic subfoveal retinal pigment epithelial detachment (RPED) in central serous chorioretinopathy and identify prognostic factors affecting treatment outcome. METHODS: This retrospective interventional study included 35 eyes of 35 patients with serous subfoveal RPED with choroidal hyperpermeability. Cases with evidence of age-related macular degeneration were excluded from the study...
March 5, 2018: Retina
https://www.readbyqxmd.com/read/29511746/retinal-pigment-epithelium-changes-in-kartagener-syndrome
#17
Maria D Garcia, Camila V Ventura, João R Dias, Ta Chen P Chang, Audina M Berrocal
Purpose: We present the first case in the literature of a patient with Kartagener syndrome and ocular findings of nonexudative age-related macular degeneration. Observations: A 55-year-old woman with Kartagener syndrome and chronic angle closure glaucoma presented for evaluation of the retina. Optos ultra-widefield imaging of the fundus showed glaucomatous cupping, drusen, and retinal pigment epithelium changes within the macular region. Humphrey visual field testing confirmed glaucomatous changes...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29503946/giant-retinal-pigment-epithelial-tear-associated-with-fluid-overload-due-to-end-stage-diabetic-kidney-disease
#18
Yusuke Kameda, Akira Hirose, Tomohiro Iida, Yasuko Uchigata, Shigehiko Kitano
Purpose: To report a case of a giant retinal pigment epithelial (RPE) tear associated with fluid overload in a patient with diabetic macular edema (DME) and kidney disease. Observations: A 60-year-old man with type 2 diabetes mellitus and end-stage diabetic kidney disease who had gained weight because of fluid overload complained of a visual disturbance in the left eye that had started a few days earlier. The left fundus showed a RPE defect in two temporal quadrants under an extensive serous retinal detachment (SRD) with exacerbation of the original DME...
April 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29474307/identification-of-posterior-segment-pathology-with-en-face-retinal-imaging-using-multicolor-confocal-scanning-laser-ophthalmoscopy
#19
Henry L Feng, Sumit Sharma, Sandra Stinnett, Sanjay Asrani, Prithvi Mruthyunjaya
PURPOSE: To assess posterior segment findings on multicolor confocal scanning laser ophthalmoscopy by correlation with spectral domain optical coherence tomography (SD-OCT) and to quantify agreement between these imaging modalities. METHODS: Retrospective review of 159 eyes of 96 consecutive patients who underwent concurrent imaging with multicolor confocal scanning laser ophthalmoscopy and SD-OCT. Positive percent agreement and negative percent agreement were calculated for each finding identified on infrared, green, blue, and multicolor reflectance images using SD-OCT as a comparator...
February 22, 2018: Retina
https://www.readbyqxmd.com/read/29468211/treatment-of-retinal-pigment-epithelial-detachment-secondary-to-exudative-age-related-macular-degeneration
#20
Andres Gonzalez, Gibran Khurshid
Purpose: This pilot study evaluated the combination of photodynamic therapy (PDT) and anti-vascular endothelial growth factor (anti-VEGF) as a treatment in patients with a pigment epithelial detachment (PED) due to exudative age-related degeneration (AMD). Methods: We analyzed seven consecutive patients between September 1, 2015 and September 1, 2017 with a PED secondary to exudative AMD who were treated with full fluence standard PDT and a series of monthly intravitreal anti-VEGF injections...
March 2018: American Journal of Ophthalmology Case Reports
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