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Pigment epithelial detachment

Ramesh Venkatesh, Prachi Gurav, Prachi A Dave
PURPOSE: To report a case of choroidal neovascular membrane after vitreoretinal surgery in a patient with macular hole-induced retinal detachment. METHODS: Retrospective observational case report. CASE DESCRIPTION: A 64-year-old lady presented with sudden drop in vision in the right eye since 20 days. Her best-corrected visual acuity was 6/36 in the right eye and 6/18 in the left eye. She was diagnosed with retinal detachment with a macular hole in the right eye...
October 3, 2016: Retinal Cases & Brief Reports
Aniruddha Agarwal, Alessandro Invernizzi, Neha Kumari, Ramandeep Singh
PURPOSE: Retinochoroidal anastamosis (RCA) is known to be associated with retinal angiomatous proliferans rather than idiopathic macular telangiectasia. The case report describes a rare association of bilateral RCA with type II idiopathic macular telangiectasia in an elderly woman. CASE REPORT: A 65-year-old female patient presented with decreased vision in both eyes to the ophthalmology clinic. She was diagnosed with bilateral large serous retinal pigment epithelial detachments (PED)...
October 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Anna C S Tan, Daniel Simhaee, Chandrakumar Balaratnasingam, Kunal K Dansingani, Lawrence A Yannuzzi
PURPOSE: To describe and compare the clinical and imaging characteristics of pigment epithelial detachments (PEDs) in age-related macular degeneration (AMD), polypoidal choroidal vasculopathy (PCV) and central serous chorioretinopathy (CSC) as seen in a clinical setting of a tertiary retinal practice. DESIGN: A perspective supported by clinical and imaging characteristics of a consecutive, cohort of patients with strictly defined PEDs. RESULTS: 174 eyes of 113 patients with PEDs were studied with comprehensive clinical retinal examination and multi-modal imaging; PEDs were differentiated into non-vascularized and vascularized forms with 3 main underlying etiologies: AMD (76%), PCV (9%) and CSC (3%)...
September 13, 2016: American Journal of Ophthalmology
Xuejing Chen, Mayss Al-Sheikh, Clement K Chan, Amir H Hariri, Prema Abraham, Maziar Lalezary, Steven G Lin, SriniVas Sadda, David Sarraf
PURPOSE: To evaluate the response to aflibercept therapy for Type 1 and Type 3 neovascularization in pigment epithelial detachments associated with treatment-naive, neovascular age-related macular degeneration. METHODS: In this multicentered, prospective study, eligible eyes underwent an intravitreal aflibercept injection protocol for 12 months. Visual acuity and morphologic features of the pigment epithelial detachments were compared at baseline and follow-up intervals between eyes with Type 1 versus Type 3 neovascularization...
September 8, 2016: Retina
Bedia Begüm Karakoçak, Ramesh Raliya, Josh T Davis, Sanmathi Chavalmane, Wei-Ning Wang, Nathan Ravi, Pratim Biswas
Gold nanoparticles (Au NPs) have been tested as targeted delivery agents because of their high chemical stability and surface plasmon properties. Here, we investigated the biocompatibility of Au spheres (5-, 10-, 20-, 30-, 50-. and 100-nm), cubes (50-nm), and rods (10×90nm) on a retinal pigment epithelial (ARPE-19) cell line. The lethal dose for killing 50% of the cells (LD50) was evaluated using an MTT (3-[4, 5 dimethyl-thiazoly-2-yl] 2-5 diphenyl tetrazolium bromide) assay. At and above LD50, based on mass concentrations, the confluent cell layer began to detach, as shown by real-time measurements of electric impedance...
December 2016: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Haipei Yao, Hui Li, Shuai Yang, Min Li, Chun Zhao, Jingfa Zhang, Guotong Xu, Fang Wang
Proliferative vitreoretinopathy (PVR), a serious vision-threatening complication of retinal detachment (RD), is characterized by the formation of contractile fibrotic membranes, in which epithelial-mesenchymal transition (EMT) of the retinal pigment epithelium (RPE) is a major event. Recent studies suggest an important role of bone morphogenetic protein 4 (BMP4) in the suppression of fibrosis. In this study, we aimed to investigate the role of BMP4 in the pathological process of PVR, particularly in the EMT of RPE cells...
2016: Scientific Reports
Daniel Su, Shawn Lin, Nopasak Phasukkijwatana, Xuejing Chen, Anna Tan, K Bailey Freund, David Sarraf
PURPOSE: To comprehensively investigate spectral domain optical coherence tomography features associated with Type 3 neovascularization and determine the prevalence of each feature and to develop an updated staging system for Type 3 neovascularization based on spectral domain optical coherence tomography findings. METHODS: The authors retrospectively analyzed 34 eyes with new-onset Type 3 neovascularization. Spectral domain optical coherence tomography images at onset of Type 3 neovascularization, immediately after the first injection, and at the final quiescent visit were analyzed for the presence of specific optical coherence tomography features...
August 29, 2016: Retina
David Sarraf, Nikolas J S London, Rahul N Khurana, Pravin U Dugel, Shamika Gune, Lauren Hill, Lisa Tuomi
PURPOSE: To analyze the effect of baseline presence and height of pigment epithelial detachments (PEDs) on visual and anatomic outcomes at 24 months in patients with neovascular age-related macular degeneration (AMD) treated with ranibizumab. DESIGN: Post hoc analysis of HARBOR, a 24-month, phase III, randomized, multicenter, double-masked, active treatment-controlled study ( identifier, NCT00891735). PARTICIPANTS: One thousand ninety-seven patients with neovascular AMD...
October 2016: Ophthalmology
Jesse T McCann, Michael Engelbert
PURPOSE: To report a giant retinal pigment epithelium rip in a patient with a bullous retinal and choroidal detachment. METHODS: Case report with widefield imaging, fundus autofluorescence, and optical coherence tomography of the retina. RESULTS: This 62-year-old patient had a history of advanced glaucoma, trabeculectomy, blebitis, and endophthalmitis. He had cataract surgery 6 weeks before presentation. He was found to have a large bullous retinal and choroidal detachment with a large retinal pigment epithelium tear at the limit of the choroidal detachment...
August 9, 2016: Retinal Cases & Brief Reports
Maiko Inoue, Anna Tan, Jason S Slakter, Stanley Chang, Kazuaki Kadonosono, Lawrence A Yannuzzi
PURPOSE: To describe two patients who showed full-thickness macular holes (FTMH) combined with pigment epithelial detachments (PED) and had contrasting outcomes to treatment. METHODS: A retrospective report of two cases. RESULTS: Case 1 was treated with intravitreal antivascular endothelial growth factor and photodynamic therapy, and the PED flattened. Subsequently, a vitrectomy was performed and the FTMH closed. Her visual acuity improved from 20/200 to 20/25...
August 8, 2016: Retinal Cases & Brief Reports
Dong Kyu Lee, Soon Hyun Kim, Yong Sung You, Oh Woong Kwon
PURPOSE: Intravitreal anti-vascular endothelial growth factor (anti-VEGF) is the first choice of treatment for age-related macular degeneration. However, quite a few eyes treated using conventional dose anti-VEGF (CDAV) have persistent pigment epithelial detachment (PED) on optical coherence tomography. This study investigated the efficacy and safety of high dose anti-VEGF (HDAV) for refractory PED. METHODS: In this retrospective study, 31 eyes of neovascular age-related macular degeneration patients with persistent PED findings despite six or more intravitreal injections of CDAV (bevacizumab 1...
August 2016: Korean Journal of Ophthalmology: KJO
Min Wang, Yao Zhou, Simon S Gao, Wei Liu, Yongheng Huang, David Huang, Yali Jia
PURPOSE: We observed and analyzed the morphologic characteristics of polypoidal lesions and abnormal branching vascular network (BVN) in patients with polypoidal choroidal vasculopathy (PCV) by optical coherence tomography angiography (OCTA). METHODS: A retrospective observational case series was done of patients with PCV. All patients were scanned with a 70-kHz spectral-domain OCT system using the split-spectrum amplitude-decorrelation angiography (SSADA) algorithm to distinguish blood flow from static tissue...
July 1, 2016: Investigative Ophthalmology & Visual Science
Gregg T Kokame, James C Lai, Raymond Wee, Ryan Yanagihara, Jessica G Shantha, Julia Ayabe, Kelsi Hirai
BACKGROUND: Polypoidal choroidal vasculopathy is a variant of choroidal neovascularization and neovascular age related macular degeneration presenting with hemorrhagic and exudative changes within the macula and/or peripapillary region leading to vision loss. In contrast to neovascular age related macular degeneration, polypoidal choroidal vasculopathy has differing clinical manifestations and treatment strategies. Historically, polypoidal choroidal vasculopathy complexes are less responsive to anti-vascular endothelial growth factor therapy with no prospective clinical trials evaluating aflibercept in management of polypoidal choroidal vasculopathy...
2016: BMC Ophthalmology
Ibrahim Kocak
The purpose of the study was to assess the efficacy and safety of transition from ranibizumab to aflibercept intravitreal injections in treatment-resistant retinal pigment epithelial detachment (PED). The data of intravitreal ranibizumab treatment-resistant patients who have been switched to aflibercept treatment were reviewed retrospectively. After three monthly injections, bimonthly regimen was performed. The changes of PED height and radius, and the best-corrected visual acuity (BCVA) were analyzed retrospectively...
July 21, 2016: International Ophthalmology
Ryan N Vogel, Drew B Davis, Brad H Kimura, Senthil Rathinavelu, Gabrielle S Graves, Aniko Szabo, Dennis P Han
PURPOSE: To describe visual outcome and prognostic indicators in neovascular age-related macular degeneration with advanced visual loss at the initiation of anti-vascular endothelial growth factor therapy. METHODS: A retrospective chart review was performed on a consecutive series of 1,410 patients with neovascular age-related macular degeneration treated with anti-vascular endothelial growth factor therapy at the Medical College of Wisconsin. Subjects were included if at the initiation of therapy they had 20/200 or worse visual acuity (VA) with no other visually limiting eye disease and a minimum follow-up of 6 months...
July 14, 2016: Retina
Neha Goel, Vishaal Bhambhwani, Pooja Jain, Basudeb Ghosh
PURPOSE: To describe an unusual retinal manifestation of dengue fever in an endemic region. CASE REPORT: A 35 year old male presenting with acute onset decreased vision in his right eye, was found to have a massive retinal pigment epithelial detachment (PED) extending up to the vascular arcades. He had been diagnosed with acute hypokalemic quadriparesis in dengue fever in the preceding week, which had resolved following treatment. The patient was managed conservatively...
April 2016: Journal of Ophthalmic & Vision Research
Maiko Inoue, Jesse J Jung, Chandrakumar Balaratnasingam, Kunal K Dansingani, Elona Dhrami-Gavazi, Mihoko Suzuki, Talisa E de Carlo, Abtin Shahlaee, Michael A Klufas, Adil El Maftouhi, Jay S Duker, Allen C Ho, Maddalena Quaranta-El Maftouhi, David Sarraf, K Bailey Freund
PURPOSE: To determine the sensitivity of the combination of optical coherence tomography angiography (OCTA) and structural optical coherence tomography (OCT) for detecting type 1 neovascularization (NV) and to determine significant factors that preclude visualization of type 1 NV using OCTA. METHODS: Multicenter, retrospective cohort study of 115 eyes from 100 patients with type 1 NV. A retrospective review of fluorescein (FA), OCT, and OCTA imaging was performed on a consecutive series of eyes with type 1 NV from five institutions...
July 1, 2016: Investigative Ophthalmology & Visual Science
Norihiro Nagai, Misa Suzuki, Atsuro Uchida, Toshihide Kurihara, Mamoru Kamoshita, Sakiko Minami, Hajime Shinoda, Kazuo Tsubota, Yoko Ozawa
The prognosis of neovascular age-related macular degeneration (AMD) has been improved by anti-vascular endothelial growth factor treatments, including intravitreal aflibercept (IVA) treatment. However, many patients remain incurable. In this study, we retrospectively evaluated non-responsiveness to IVA monotherapy at 12 months in 133 eyes of 133 AMD patients. Sixty-two patients were initially treatment-naive, and 71 had received other treatments before IVA (the treatment-switched group). Mean best-corrected visual acuity (BCVA) was improved in the treatment-naive group but not in the treatment-switched group, although mean central retinal thickness (CRT) decreased in both groups...
2016: Scientific Reports
Akihito Kasai, Naotaka Kanda, Tetsuju Sekiryu
PURPOSE: We report a case of bilateral serous retinal detachment (SRD) associated with inferior posterior staphyloma (IPS) treated successfully with scleral shortening. PATIENT AND METHODS: A 63-year-old woman presented with bilateral visual loss due to an SRD with IPS. The best-corrected visual acuity levels were 0.6 (20/30) and 0.5 (20/40) in the right and left eye, respectively. The patient underwent vitrectomy and scleral shortening in the right eye. The lamellar scleral crescent was resected 4 mm in width from the 5- to 8-o'clock positions...
May 2016: Case Reports in Ophthalmology
Serra Arf, Mumin Hocaoglu, Isil Sayman Muslubas, Murat Karacorlu
The purpose of the study was to evaluate the effect of reduced-fluence photodynamic therapy (RFPDT) for chronic central serous chorioretinopathy (CSC) associated with serous retinal detachment (SRD) and fovea-involving pigment epithelial detachment (PED). Ten eyes of ten patients with chronic CSC associated with combined SRD and PED involving the fovea were included. RFPDT was applied to the hyperfluorescent area identified at the mid-to-late phase of indocyanine green angiography, which indicated the area of leakage...
July 8, 2016: International Ophthalmology
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