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Choroidal neovascularisation

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https://www.readbyqxmd.com/read/29150217/idiopathic-macular-telangiectasia-type-2-prevalence-and-a-morphometric-and-phenotypic-study
#1
R M Bayón-Porras, I Pascual-Camps, C Plaza-Laguardia, R Gallego-Pinazo
OBJECTIVE: Type 2 idiopathic macular telangiectasia (MacTel2) is a rare retinal disease that has still not been well-defined. The aim of the present manuscript is to describe the clinical features by multimodal retinal imaging, to present the functional characteristics, and to estimate the prevalence of the disease. METHODS: A retrospective study was conducted on the 12 eyes of 6 patients with MacTel2. Fundus colour photographs, fundus autofluorescence, fluorescein angiography, optical coherence tomography (OCT), and OCT-angiography were performed and subsequently analysed...
November 14, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29109897/optic-coherence-angiography-findings-in-type-2-macular-telangiectasia
#2
Hilal Nalcı, Figen Şermet, Sibel Demirel, Emin Özmert
Objectives: To evaluate the vascular changes of idiopathic macular telangiectasia type 2 (MacTel 2) patients with optical coherence tomography angiography (OCTA) and correlate these changes with the findings of spectral domain optical coherence tomography (SD-OCT). Materials and Methods: Simultaneous SD-OCT and OCTA images of 10 eyes of 6 patients who were diagnosed as MacTel 2 in Ankara University Faculty of Medicine, Department of Ophthalmology were obtained and graded according to the OCTA grading system for MacTel 2...
October 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29097668/advanced-glycation-end-products-promote-vegf-expression-and-thus-choroidal-neovascularization-via-cyr61-pi3k-akt-signaling-pathway
#3
Lijuan Sun, Tonglie Huang, Wenqin Xu, Jiaxing Sun, Yang Lv, Yusheng Wang
Choroidal neovascularisation (CNV) causes severe vision loss among old patients, especially those with diabetes. Previously, Cyr61 has been found to play a critical role in the pathogenesis of both AMD and diabetes. In the present study, we found that increased CNV severity together with higher expression of Cyr61 and VEGF in diabetes mice compared with control mice. Moreover, knockdown of Cyr61 decreased CNV severity. In vitro mechanism study revealed that the advanced glycation end products (AGEs) significantly increased the expression of Cyr61 in retinal pigment epithelial (RPE) cells, mimicking the effects of diabetes...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29050001/expression-of-angiogenic-and-inflammatory-factors-in-choroidal-neovascularisation-derived-retinal-pigment-epithelium
#4
Christoph Ehlken, Maria-Magdalena Guichard, Günther Schlunck, Anima D Bühler, Gottfried Martin, Hansjürgen T Agostini
PURPOSE: Anti-angiogenic treatment is well established in the management of exudative age-related macular degeneration (AMD), but not sufficient in all patients. The characterisation of factors driving this chronic disease could serve to identify additional treatment options. The purpose of this study was to assess gene expression patterns and distinct changes in cells derived from surgically extracted choroidal neovascularisation (CNV) membranes. MATERIALS AND METHODS: The expression of >11,000 genes was analysed by means of a microarray in cells cultured from 2 late-stage CNV membranes compared to primary human retinal pigment epithelium (RPE) and ARPE-19 cells...
October 20, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28972027/choroidal-neovascularisation-triggered-multiple-evanescent-white-dot-syndrome-mewds-in-predisposed-eyes
#5
Thibaud Mathis, Benoit Delaunay, Armelle Cahuzac, Vivien Vasseur, Martine Mauget-Faÿsse, Laurent Kodjikian
BACKGROUND: Multiple evanescent white dot syndrome (MEWDS) is an inflammatory disease that can be associated with choroidalneovascularisation (CNV). However, few studies in the literature have described the occurrence of MEWDS in association with CNV. This paper discusses whether CNV can trigger MEWDS in a predisposed eye. METHODS: A retrospective multicentric case series of six eyes in six patients with acute onset of MEWDS and evidence of previous CNV was conducted between January 2015 and January 2017...
September 28, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28939808/novel-pathogenic-mutations-in-c1qtnf5-support-a-dominant-negative-disease-mechanism-in-late-onset-retinal-degeneration
#6
Chloe M Stanton, Shyamanga Borooah, Camilla Drake, Joseph A Marsh, Susan Campbell, Alan Lennon, Dinesh C Soares, Neeru A Vallabh, Jayashree Sahni, Artur V Cideciyan, Baljean Dhillon, Veronique Vitart, Samuel G Jacobson, Alan F Wright, Caroline Hayward
Late-onset retinal degeneration (L-ORD) is a rare autosomal dominant retinal dystrophy, characterised by extensive sub-retinal pigment epithelium (RPE) deposits, RPE atrophy, choroidal neovascularisation and photoreceptor cell death associated with severe visual loss. L-ORD shows striking phenotypic similarities to age-related macular degeneration (AMD), a common and genetically complex disorder, which can lead to misdiagnosis in the early stages. To date, a single missense mutation (S163R) in the C1QTNF5 gene, encoding C1q And Tumor Necrosis Factor Related Protein 5 (C1QTNF5) has been shown to cause L-ORD in a subset of affected families...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28895632/-oct-angiography-in-exudative-amd-with-detachment-of-vascularised-retinal-pigment-epithelium
#7
Frederic Gunnemann, Kai Rothaus, Marie-Louise Farecki, Henrik Faatz, Benedikt Book, Albrecht Lommatzsch, Daniel Pauleikoff
Background The aim of the following extended case study was to analyse whether choroidal neovascularisation (CNV) in vascularised epithelial detachments (PED) in OCT angiography (OCT-A) can be better visualised in OCT-A than in the established angiographic methods during the course of anti-VEGF therapy and if possible used to quantify the CNV size and flow area. These findings were compared with other SD-OCT characteristics of the lesion (PED height, retinal thickness). Patients and Methods 8 patients with PED and associated CNV were diagnosed with multimodal imaging and additionally OCT angiography was performed...
September 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28895628/-exudative-amd-in-oct-angiography
#8
Marie-Louise Farecki, Matthias Gutfleisch, Henrik Faatz, Kai Rothaus, Albrecht Lommatzsch, Daniel Pauleikoff
OCT angiography provides a combination of vascular and structural information. In contrast to conventional fluorescein angiography, there is no need for dye injection to give an image of choroidal neovascularisation. Although there is currently no classification of OCT angiography, different neovascular patterns can be observed, with criteria for activity. In the future, OCT angiography may help us to understand pathophysiological mechanisms and to develop therapeutic strategies.
September 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28855197/optical-coherence-tomography-angiography-reproducibility-of-lesion-size-measurements-in-neovascular-age-related-macular-degeneration-amd
#9
Francesca Amoroso, Alexandra Miere, Oudy Semoun, Camille Jung, Vittorio Capuano, Eric H Souied
PURPOSE: To evaluate the reproducibility and interuser agreement of measurements of choroidal neovascularisation in optical coherence tomography angiography (OCTA). DESIGN: Prospective non-interventional study. METHODS: Consecutive patients, presenting with neovascular age-related macular degeneration (AMD), underwent two sequential OCTA examinations (AngioVue, Optovue, Fremont, California, USA), performed by the same trained examiner. Neovascular lesion area was then measured on both examinations in the choriocapillaris automatic segmentation by two masked readers, using the semiautomated measuring software embedded in the instrument...
August 30, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28844051/active-surveillance-of-choroidal-neovascularisation-in-children-incidence-aetiology-and-management-findings-from-a-national-study-in-the-uk
#10
Mariya Moosajee, Alessandro Abbouda, Barnaby Foot, Catey Bunce, Anthony T Moore, James Acheson
BACKGROUND/AIMS: To determine the UK incidence, demographics, aetiology, management and visual outcome for children developing choroidal neovascularisation (CNV). METHODS: A prospective population-based observational study of routine practice via the British Ophthalmological Surveillance Unit between January 2012 and December 2013 with subsequent 1-year follow-up in children under 16 years old with newly diagnosed CNV. RESULTS: Twenty-seven children with CNV were reported...
August 26, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28820184/age-related-macular-degeneration-and-mortality-the-melbourne-collaborative-cohort-study
#11
M B McGuinness, R P Finger, A Karahalios, R H Guymer, D R English, E W Chong, A M Hodge, L D Robman, G G Giles, J A Simpson
AimsTo assess associations between features of age-related macular degeneration (AMD) and mortality.MethodsA total of 21 129 participants from the Melbourne Collaborative Cohort Study aged 47-85 years (60% female) were assessed for AMD (2003-2007). Mortality data to December 31, 2012 were obtained through linkage with the National Death Index. Associations were assessed using Cox regression, adjusting for age, sex, smoking, region of birth, education, physical activity, diet and alcohol.ResultsLate AMD was identified in 122 (0...
September 2017: Eye
https://www.readbyqxmd.com/read/28814417/intravitreal-bevacizumab-monotherapy-in-myopic-choroidal-neovascularisation-5-year-outcomes-for-the-pan-american-collaborative-retina-study-group
#12
Jay Chhablani, Remya Mareen Paulose, Andres F Lasave, Lihteh Wu, Cristian Carpentier, Mauricio Maia, Silvio Lujan, Sergio Rojas, Martin Serrano, Maria H Berrocal, J Fernando Arevalo
PURPOSE: To report the long-term anatomical and visual outcomes of intravitreal bevacizumab (IVB) monotherapy in naive choroidal neovascularisation (CNV) caused by myopia. METHODS: Retrospective analysis of naive CNV secondary to myopia that underwent antivascular endothelial growth factor monotherapy was performed. Collected data included demographic details, clinical examination details including visual acuity at presentation and follow-up with imaging and treatment details...
August 16, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28794073/rock-inhibitors-for-the-treatment-of-ocular-diseases
#13
REVIEW
Ramin Nourinia, Shintaro Nakao, Souska Zandi, Sare Safi, Ali Hafezi-Moghadam, Hamid Ahmadieh
The Rho-kinase/ROCK (Rho-associated coiled-coil-containing protein kinase) pathway is involved in the pathogenesis of multiple ocular and systemic disorders. Recently, ROCK inhibitors have been suggested as novel treatments for various ocular diseases. Several in vitro, in vivo and clinical studies have demonstrated the safety and efficacy of ROCK inhibitors in the management of ocular disorders such as corneal epithelial and endothelial damage, glaucoma, retinal and choroidal neovascularisation, diabetic macular oedema and optic nerve disorders...
August 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28765145/optical-coherence-tomography-angiography-characterisation-of-best-disease-and-associated-choroidal-neovascularisation
#14
Abhilash Guduru, Arushi Gupta, Mudit Tyagi, Subhadra Jalali, Jay Chhablani
AIMS: To characterise the vasculature of the retina in patients with Best vitelliform dystrophy, including those with choroidal neovascularisation (CNV), using optical coherence tomography angiography (OCTA) and correlate with fluorescein angiography (FA). METHODS: This prospective observational study included 19 eyes of 10 patients with Best disease. Using OCTA, all layers of retina were qualitatively characterised for each eye. Patients with CNV also underwent FA, and areas of CNV were measured by OCTA and FA and correlated...
August 1, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28647308/playing-with-future-sight-choroidal-neovascularisation-due-to-hand-held-laser-pointers
#15
R Gallego-Pinazo, C Plaza-Laguardia, M R Bayón-Porras, H Barranco
No abstract text is available yet for this article.
June 21, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28600301/features-of-optical-coherence-tomography-predictive-of-choroidal-neovascularisation-treatment-response-in-pathological-myopia-in-association-with-fluorescein-angiography
#16
Dong Hyun Lee, Hyun Goo Kang, Sung Chul Lee, Min Kim
BACKGROUND/AIMS: The aim of this study was to evaluate the usefulness of several optical coherence tomography (OCT) findings to estimate choroidal neovascularisation (CNV) activity in pathological myopia using fluorescein angiography (FA) as a reference. METHODS: This was a single-centre, retrospective study. The medical records of patients with active myopic CNV who received intravitreal bevacizumab treatment were reviewed. Parameters to monitor CNV activity were morphological features of CNV on OCT, such as CNV height, central foveal thickness, intraretinal cysts, subretinal fluid, fuzziness of the CNV border, CNV network area on FA, and haemorrhage or exudation on fundus photo...
June 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28583400/focal-choroidal-excavaction-associated-with-idiopathic-choroidal-neovascularization
#17
J L Sánchez-Vicente, T Rueda-Rueda, A C Martínez-Borrego, A Moruno-Rodríguez, F E Molina-Socola, M Contreras-Díaz, A Medina-Tapia, A Muñoz-Morales, F López-Herrero
CASE REPORT: The case is presented of a 45 year-old man with a focal choroidal excavation associated with choroidal neovascularisation not included in the area of excavation. Clinical features were analysed using retinography, fluorescein angiography, optical coherence tomography, and optical coherence tomography angiography. The patient was treated with 3 intravitreal injections of bevacizumab, with a good response. DISCUSSION: Focal choroidal excavation can be associated with choroidal neovascularization not included in the area of excavation...
June 2, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28579218/choroidal-nevus-or-melanoma-choroidal-neovascularisation-as-a-confounder-in-choroidal-nevus
#18
O Subira, H Brosa, D Lorenzo, J M Caminal
No abstract text is available yet for this article.
May 31, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28289053/vegf165-induced-vascular-permeability-requires-nrp1-for-abl-mediated-src-family-kinase-activation
#19
Alessandro Fantin, Anastasia Lampropoulou, Valentina Senatore, James T Brash, Claudia Prahst, Clemens A Lange, Sidath E Liyanage, Claudio Raimondi, James W Bainbridge, Hellmut G Augustin, Christiana Ruhrberg
The vascular endothelial growth factor (VEGF) isoform VEGF165 stimulates vascular growth and hyperpermeability. Whereas blood vessel growth is essential to sustain organ health, chronic hyperpermeability causes damaging tissue edema. By combining in vivo and tissue culture models, we show here that VEGF165-induced vascular leakage requires both VEGFR2 and NRP1, including the VEGF164-binding site of NRP1 and the NRP1 cytoplasmic domain (NCD), but not the known NCD interactor GIPC1. In the VEGF165-bound receptor complex, the NCD promotes ABL kinase activation, which in turn is required to activate VEGFR2-recruited SRC family kinases (SFKs)...
April 3, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28282700/-choroidal-neovascularisation-other-than-typical-neovascular-age-related-macular-degeneration
#20
D Sandner
Choroidal neovascularisation (CNV) in the context of exsudative age-related macular degeneration (nAMD) can be divided into type 1 (occult) and type 2 (classical) membranes. Retinal angiomatous proliferation (RAP) or polypoidal choroidal vasculopathy (PCV) are "rare subtypes" of chorioretinal neovascularisation and are distinguished by their distinct morphology and the sometimes worse response to therapy. Chorioretinal anastomosis, severe exsudates with serosanguinous pigment epithelial detachment and, in PCV, orange-red lesions in the papillomacular bundle can be diagnostic...
March 10, 2017: Klinische Monatsblätter Für Augenheilkunde
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