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Choroidal neovascularisation

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https://www.readbyqxmd.com/read/28192841/6-year-results-of-cnv-secondary-to-pathological-myopia-treated-with-ranibizumab
#1
L Hefner, H Gerding
Background The current standard treatment of choroidal neovascularisation (CNV) secondary to pathological myopia (PM) is intravitreal injection of VEGF antagonists. We now present our 6-year results after treating patients with CNV secondary to PM with ranibizumab. Patients and Methods We retrospectively analysed 15 treatment-naive eyes of 13 patients (10 women, 3 men, mean age 59.2; standard deviation (SD) 11.1; range 41-78 years) with visual impairment related to CNV secondary to PM, who were treated with at least 1 injection of ranibizumab...
February 13, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28119292/intravitreal-ziv-aflibercept-for-the-treatment-of-choroidal-neovascularisation-associated-with-conditions-other-than-age-related-macular-degeneration
#2
Imoro Zeba Braimah, Michael Stewart, Chetan Videkar, Chintan J Dedhia, Jay Chhablani
AIM: To report the short-term outcomes of eyes with choroidal neovascularisation (CNV) associated with causes other than age-related macular degeneration (AMD) after treatment with intravitreal ziv-aflibercept (IVZ) injections. METHODS: This retrospective study included eyes with non-AMD-related CNV that were treated with IVZ (1.25 mg/0.05 mL) on a pro re nata basis. The primary outcome measure is the mean change in best-corrected visual acuity (BCVA) and secondary outcome measures include the mean change in central macular thickness (CMT) and adverse events...
January 24, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28107458/neuropilin-1-involvement-in-choroidal-and-retinal-neovascularisation
#3
Patricia Fernández-Robredo, Senthil Selvam, Michael B Powner, Dawn A Sim, Marcus Fruttiger
PURPOSE: Inhibiting VEGF is the gold standard treatment for neovascular age-related macular degeneration (AMD). It is also effective in preventing retinal oedema and neovascularisation (NV) in diabetic retinopathy (DR) and retinal vein occlusions (RVO). Neuropilin 1 (Nrp1) is a co-receptor for VEGF and many other growth factors, and therefore a possible alternative drug target in intra ocular neovascular disease. Here we assessed choroidal and retinal NV in an inducible, endothelial specific knock out model for Nrp1...
2017: PloS One
https://www.readbyqxmd.com/read/28092911/behaviour-of-cd11b-positive-cells-in-an-animal-model-of-laser-induced-choroidal-neovascularisation
#4
Lu Li, Peter Heiduschka, Anne F Alex, Daniel Niekämper, Nicole Eter
BACKGROUND/AIM: Immune cells, e.g. microglial cells of the retina, appear to be involved in pathological processes in neovascular age-related macular degeneration. Therefore, the purpose of this study was to immunohistochemically check the expression of various factors and cytokines by CD11b-positive (CD11b+) immune cells in an animal model of choroidal neovascularisation (CNV). METHODS: We used the animal model of laser-induced CNV in mice. Eyes were isolated at 1, 4, 7, and 14 days after laser treatment...
2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/27977064/anti-vascular-endothelial-growth-factor-for-choroidal-neovascularisation-in-people-with-pathological-myopia
#5
REVIEW
Ying Zhu, Ting Zhang, Gezhi Xu, Lijun Peng
BACKGROUND: Choroidal neovascularisation (CNV) is a common complication of pathological myopia. Once developed, most eyes with myopic CNV (mCNV) experience a progression to macular atrophy, which leads to irreversible vision loss. Anti-vascular endothelial growth factor (anti-VEGF) therapy is used to treat diseases characterised by neovascularisation and is increasingly used to treat mCNV. OBJECTIVES: To assess the effects of anti-vascular endothelial growth factor (anti-VEGF) therapy for choroidal neovascularisation (CNV), compared with other treatments, sham treatment or no treatment, in people with pathological myopia...
15, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27971611/burden-of-visual-impairment-due-to-myopic-choroidal-neovascularisation-mcnv-in-turkey
#6
C Sar, S Malhan, E Oksuz, B Eldem, N Unlu, M N Alp, E Ozmert, A H Durukan, E Erdal, B Kahveci
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27913447/comparison-of-oct-angiography-and-indocyanine-green-angiographic-findings-with-subtypes-of-polypoidal-choroidal-vasculopathy
#7
Koji Tanaka, Ryusaburo Mori, Akiyuki Kawamura, Hiroyuki Nakashizuka, Yu Wakatsuki, Mitsuko Yuzawa
PURPOSE: To compare the findings of optical coherence tomography angiography (OCTA) with indocyanine green angiography (ICGA) in polypoidal choroidal vasculopathy (PCV) that was divided into two types: polypoidal choroidal neovascularisation (CNV) and typical PCV (type 2 PCV). METHODS: We studied a retrospective case series of 32 patients with treatment-naïve PCV (24 men, eight women; mean age 65.4 years). PCV was categorised into polypoidal CNV (type 1 PCV) and type 2 PCV based on ICGA findings...
January 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27913440/optical-coherence-tomographic-angiography-of-choroidal-neovascularization-ill-defined-with-fluorescein-angiography
#8
Mehrdad Malihi, Yali Jia, Simon S Gao, Christina Flaxel, Andreas K Lauer, Thomas Hwang, David J Wilson, David Huang, Steven T Bailey
PURPOSE: To evaluate the morphological structure of ill-defined choroidal neovascularisation (CNV) with traditional fluorescein angiography (FA) compared with optical coherence tomographic angiography (OCTA). METHODS: A retrospective case series study of 11 eyes with ill-defined CNV on FA was performed. Eyes were scanned with commercially available spectral-domain optical coherence tomography (OCT) (70 000 A-scans/s). The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to distinguish blood flow from static tissue...
January 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27816486/treat-and-extend-approach-with-aflibercept-effects-on-different-subtypes-of-age-related-choroidal-neovascularisation
#9
V Castro-Navarro, E Cervera-Taulet, J Montero-Hernández, C Navarro-Palop
OBJECTIVE: To describe functional/morphological outcomes of treat-and-extend (TAE) with aflibercept in different subtypes of neovascularizations (CNV) secondary to exudative age-related macular degeneration (AMD). METHODS: Retrospective study was conducted on 30 eyes of 30 patients treated with 2 mg-aflibercept according to a TAE protocol. Examinations included best corrected visual acuity (BCVA), number of injections, and visits needed. A quantitative/qualitative analysis was also performed with fluorescein angiography and spectral-domain optical coherence tomography (SD-OCT) at baseline, and at 3, 6, and 12 months...
November 2, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27815677/-choroidal-neovascularisation-in-a-patient-with-choroidal-osteoma-visualized-by-oct-angiography
#10
N Mihailovic, M Alnawaiseh, R-L Merté, N Eter
We present the case of a 38-year-old Asian patient who reported vision loss of her left eye since 4 weeks. The funduscopy showed a choroidal tumor in the papillomacular bundle, which could be identified as a choroidal osteoma with secondary choroidal neovascularization (CNV). OCT angiography (OCT-A) detected abnormal flow in the choriocapillaris; the osteoma showed no flow in the OCT angiogram of the choroid level. Therefore, OCT-A can be a helpful adjuvant for diagnosis of CNV secondary to choroidal osteoma...
November 4, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27810558/single-ocular-injection-of-a-sustained-release-anti-vegf-delivers-6months-pharmacokinetics-and-efficacy-in-a-primate-laser-cnv-model
#11
Peter Adamson, Thomas Wilde, Eric Dobrzynski, Caroline Sychterz, Rodd Polsky, Edit Kurali, Richard Haworth, Chi-Man Tang, Justyna Korczynska, Fiona Cook, Irene Papanicolaou, Lemy Tsikna, Chris Roberts, Zoe Hughes-Thomas, James Walford, Daniel Gibson, John Warrack, Jos Smal, Ruud Verrijk, Paul E Miller, T Michael Nork, Jeffery Prusakiewicz, Timothy Streit, Steven Sorden, Craig Struble, Brian Christian, Ian R Catchpole
A potent anti-vascular endothelial growth factor (VEGF) biologic and a compatible delivery system were co-evaluated for protection against wet age-related macular degeneration (AMD) over a 6month period following a single intravitreal (IVT) injection. The anti-VEGF molecule is dimeric, containing two different anti-VEGF domain antibodies (dAb) attached to a human IgG1 Fc region: a dual dAb. The delivery system is based on microparticles of PolyActive™ hydrogel co-polymer. The molecule was evaluated both in vitro for potency against VEGF and in ocular VEGF-driven efficacy models in vivo...
December 28, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27748129/-angiography-of-the-ocular-fundus-without-dye-optical-coherence-tomography-based-angiography-in-exsudative-age-related-macular-degeneration
#12
Miklós Resch, Csilla Németh, György Barcsay, Mónika Ecsedy, Ágnes Borbándy, Zsuzsanna Géhl, Anikó Balogh, Antal Szabó, Zoltán Zsolt Nagy, András Papp
INTRODUCTION: Vascular endothelial growth factor antibody therapy is an established treatment of exsudative age-related macular degeneration. AIM: The morphologic characterisation of the macular microvasculature after longstanding treatment. METHOD: Forty-eight patients (34 women and 14 men; age, 74.4 ± 8.0 years) were enrolled in the study. During follow-up time (53.8 ± 31.0 months), 7.6 ± 4.9 injections were administered in 56 eyes. Optical coherence tomography angiographic examination was performed with AngioVue (Optovue Inc...
October 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27681348/enucleation-for-haemophthalmus-secondary-to-choroidal-neovascularisation-in-polypoidal-choroidal-vasculopathy-a-therapeutic-and-diagnostic-dilemma
#13
Noor Aniah Azmi, Amin Ahem, Mushawiahti Mustapha, Mae-Lynn Catherine Bastion
We report a case of enucleation for painful blind eye secondary to recurrent bleeding from choroidal neovascularisation in an eye that was irradiated following presumed metastatic breast carcinoma to the choroid. A 58-year-old woman with a history of treated breast malignancy presented with haemophthalmus and intractable glaucoma in the right eye. One year previously she had presented with right vitreous haemorrhage with subretinal mass that had been irradiated given her history of breast carcinoma. Following irradiation, vitrectomy was performed to clear the blood...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27597740/short-term-efficacy-of-intravitreal-aflibercept-depending-on-angiographic-classification-of-polypoidal-choroidal-vasculopathy
#14
Seongyong Jeong, Min Sagong
BACKGROUND/AIMS: To compare the short-term efficacy of intravitreal aflibercept treatment according to the subtypes of polypoidal choroidal vasculopathy (PCV) based on indocyanine green angiography (ICGA). METHODS: Twenty-nine patients (29 eyes) with treatment-naïve subfoveal PCV were consecutively enrolled in this institutional study. The subjects were classified into two subtypes (type 1, polypoidal choroidal neovascularisation (CNV), 16 eyes; and type 2, idiopathic PCV, 13 eyes) based on the presence or absence of both feeder and draining vessels on ICGA...
September 5, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27577973/angptl4-%C3%AE-v%C3%AE-3-interaction-counteracts-hypoxia-induced-vascular-permeability-by-modulating-src-signalling-downstream-of-vascular-endothelial-growth-factor-receptor-2
#15
Elisa Gomez Perdiguero, Athanasia Liabotis-Fontugne, Mélanie Durand, Clément Faye, Sylvie Ricard-Blum, Manuel Simonutti, Sébastien Augustin, Bryan M Robb, Michel Paques, David M Valenzuela, Andrew J Murphy, George D Yancopoulos, Gavin Thurston, Ariane Galaup, Catherine Monnot, Stéphane Germain
Dynamic control of endothelial cell junctions is essential for vascular homeostasis and angiogenesis. We recently provided genetic evidence that ANGPTL4 is a key regulator of vascular integrity both during developmental and in hypoxia-induced pathological conditions. The purpose of the present study was to decipher the molecular mechanisms through which ANGPTL4 regulates vascular integrity. Using surface plasmon resonance and proximity ligation assays, we show that ANGPTL4 binds integrin αvβ3. In vitro and in vivo functional assays with Angptl4-deficient mice demonstrate that ANGPTL4-αvβ3 interaction is necessary to mediate ANGPTL4 vasoprotective effects...
December 2016: Journal of Pathology
https://www.readbyqxmd.com/read/27558081/bilateral-choroidal-neovascularisation-associated-with-adult-onset-foveomacular-vitelliform-dystrophy
#16
Cheryl P Au, Vivek B Pandya, Paul Mitchell
No abstract text is available yet for this article.
January 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/27539089/choroidal-neovascularisation-on-optical-coherence-tomography-angiography-in-punctate-inner-choroidopathy-and-multifocal-choroiditis
#17
Ashleigh L Levison, Kimberly M Baynes, Careen Y Lowder, Peter K Kaiser, Sunil K Srivastava
PURPOSE: To describe the findings seen on optical coherence tomography angiography (OCTA) in patients with punctate inner choroidopathy (PIC) and multifocal choroiditis and panuveitis (MCP) complicated by choroidal neovascular membranes. METHODS: This was an Institutional Review Board-approved prospective, descriptive case series. 12 patients with PIC and MCP complicated by choroidal neovascularisation (CNV) were included. Each patient underwent slit-lamp examination by a uveitis specialist followed by conventional spectral domain OCT imaging of the macula...
August 18, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27531357/optical-coherence-tomography-angiography-of-myopic-choroidal-neovascularisation
#18
Lea Querques, Chiara Giuffrè, Federico Corvi, Ilaria Zucchiatti, Adriano Carnevali, Luigi A De Vitis, Giuseppe Querques, Francesco Bandello
BACKGROUND/AIMS: To describe the morphological features of choroidal neovascularisation (CNV) and to report the ability of optical coherence tomography angiography (OCT-A) to detect the presence of myopic CNV by means of this new technique. METHODS: Myopic CNV cases were individuated from a pool of patients with pathological myopia consecutively presenting between October 2015 and March 2016. OCT-A images were assessed for classification of morphological features, and to estimate sensitivity and specificity...
August 16, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27503391/prevalence-and-quantification-of-geographic-atrophy-associated-with-newly-diagnosed-and-treatment-na%C3%A3-ve-exudative-age-related-macular-degeneration
#19
Anne Sikorav, Oudy Semoun, Sandrine Zweifel, Camille Jung, Mayer Srour, Giuseppe Querques, Eric H Souied
OBJECTIVE: To identify and quantify geographic atrophy (GA) associated with neovascular age-related macular degeneration (AMD) at initial presentation using a fundus autofluorescence (FAF) semi-automated software and to correlate the results with demographic and clinical data. DESIGN: Retrospective, observational study. METHODS: The study population consisted of treatment-naïve patients with newly diagnosed neovascular AMD. Best-corrected visual acuity, fundus photographs, infrared reflectance, FAF and spectral-domain optical coherence tomography were performed, associated with fluorescein and indocyanine green angiographies...
August 8, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27439739/image-artefacts-in-swept-source-optical-coherence-tomography-angiography
#20
Khalil Ghasemi Falavarjani, Mayss Al-Sheikh, Handan Akil, Srinivas R Sadda
PURPOSE: To describe optical coherence tomography angiography (OCTA) image artefacts in eyes with and without ocular pathologies. METHODS: The OCTA images of healthy subjects and patients with age-related macular degeneration, diabetic retinopathy and retinal vascular occlusions were retrospectively reviewed. All OCTA images were obtained using a swept-source OCTA instrument (Triton, Topcon). The frequency of various image artefacts including segmentation, banding, motion, projection, masking, unmasking, doubling of the retinal vessels, blink, stretching, out-of-window and crisscross artefacts was assessed...
July 20, 2016: British Journal of Ophthalmology
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