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Choroidal neovascularisation

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https://www.readbyqxmd.com/read/29735479/comparison-of-long-term-clinical-evolution-in-highly-myopic-eyes-with-vertical-oval-shaped-dome-with-or-without-untreated-serous-retinal-detachment
#1
Antonio García-Ben, Ignacio Garcia-Basterra, Ana González-Gómez, Isabel Baquero-Aranda, María José Morillo-Sanchez, Antonio Soler-García, Jose Manuel García-Campos
BACKGROUND: To compare the long-term clinical evolution of highly myopic eyes with vertical oval-shaped dome associated with or without untreated serous retinal detachment. METHODS: Twenty-eight patients with high myopia (40 eyes) with smooth macular elevations related to a vertical oval-shaped dome were recruited. Serous retinal detachment was investigated; 11 eyes had persistent submacular fluid (study group) and 29 eyes lacked submacular fluid (control group)...
May 7, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29605188/utility-of-maldi-tof-ms-in-an-outbreak-investigation-of-acute-endophtalmitis-following-intra-vitreal-injection
#2
Archana Angrup, Sivanantham Krishnamoorthi, Manisha Biswal, Vikas Gautam, Pallab Ray, Aniruddha Agarwal, M R Dogra, Ramandeep Singh, Deeksha Katoch, Vishali Gupta
Bevacizumab, a recombinant humanized monoclonal antibody to inhibit tumour-angiogenesis is available for off-label use for treating choroidal neovascularisation. Outbreaks have been reported after use of this drug, either because of contamination during manufacturing or the practice of multiple doses being administered from a single vial to different patients. In our institute we investigated one endopthalmitis outbreak following intra-vitreal injection of Bevacizumab, rapidly identified the Stenotrophomonas maltophilia as the causative agent and established the contaminated bevacizumab vial as the source using MALDI-TOF-MS typing...
March 29, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29581353/optical-coherence-tomography-angiography-in-comparison-with-other-multimodal-imaging-techniques-in-punctate-inner-choroidopathy
#3
Dominika Pohlmann, Uwe Pleyer, Antonia M Joussen, Sibylle Winterhalter
AIMS: To characterise punctate lesions and choroidal neovascularisation (CNV) in eyes with punctate inner choroidopathy (PIC) using current standard multimodal imaging techniques and optical coherence tomography angiography (OCTA). METHODS: In our prospective, single-centre study, 20 individuals with PIC underwent imaging with spectral-domain optical coherence tomography (SD-OCT), fluorescein angiography (FA), indocyanine green angiography, fundus autofluorescence, fundus colour photography and OCTA...
March 26, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29580755/incidence-and-clinical-outcomes-of-the-different-neovascular-forms-of-age-related-macular-degeneration-in-valencia-spain
#4
L Monje-Fernández, R Dolz-Marco, M Andreu Fenoll, V Fornes Ferrer, R Gallego-Pinazo
OBJECTIVE: To analyse the incidence and outcomes of the different neovascular subtypes in age-related macular degeneration (AMD). MATERIAL AND METHODS: A retrospective review was carried out on patients with neovascular AMD treated in the University and Polytechnic Hospital la Fe in Valencia by the same retinal physician (RGP) between December 2012 and July 2015. The anatomic classification of the neovascular lesions was recorded, as well as the number of intravitreal treatments administered and the change in visual acuity (VA) obtained throughout the follow-up...
March 23, 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29567794/early-oct-angiography-changes-of-type-1-cnv-in-exudative-amd-treated-with-anti-vegf
#5
Elisabetta Pilotto, Luisa Frizziero, Anna Rita Daniele, Enrica Convento, Evelyn Longhin, Francesca Guidolin, Raffaele Parrozzani, Fabiano Cavarzeran, Edoardo Midena
AIMS: To investigate, with optical coherence tomography angiography (OCTA), short-term changes of type 1 choroidal neovascularisation (CNV), secondary to exudative age-related macular degeneration, after anti-vascular endothelial growth factor (VEGF) treatment. METHODS: Patients affected by type 1 CNV treated with intravitreal anti-VEGF were consecutively enrolled. All patients underwent OCTA examination before and 48 hours after anti-VEGF treatment. Quantitative and qualitative vascular and morphological macular changes were evaluated...
March 22, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29556011/torpedo-maculopathy-disease-spectrum-and-associated-choroidal-neovascularisation-in-a-paediatric-population
#6
Katherine Shirley, Marie O'Neill, Rachel Gamble, Anne Ramsey, Eibhlin McLoone
PURPOSE: Torpedo maculopathy is a rare lesion of the retinal pigment epithelium. This study set out to look at these lesions in the paediatric population and determine the spectrum and features of the disease. METHODS: The paediatric ophthalmology database was used to identify eight children with torpedo maculopathy between 2012 and 2017. Fundal images and optical coherence tomography (OCT) was used to analyse the cases. RESULTS: Eight patients with torpedo maculopathy were identified, making the prevalence approximately 2 per 100,000 population under 16 years old...
March 20, 2018: Eye
https://www.readbyqxmd.com/read/29519877/type-3-neovascularisation-long-term-analysis-of-visual-acuity-and-optical-coherence-tomography-anatomical-outcomes
#7
Bora Chae, Daniel Su, Orly Gal-Or, K Bailey Freund, David Sarraf
BACKGROUND: To investigate the long-term visual and optical coherence tomography (OCT) anatomical outcomes of type 3 neovascularisation (NV) and to identify any baseline predictors of poor outcomes. METHODS: In this retrospective study, patients diagnosed with treatment naïve type 3 NV were identified and categorised into two groups: good or poor vision based on final vision at 1 year. Baseline demographic features and visual acuity (VA) and baseline and 1-year spectral domain OCT (SD-OCT) anatomical findings were studied and correlated with good versus poor visual outcomes...
March 8, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29439089/yellow-577-nm-micropulse-laser-versus-half-dose-verteporfin-photodynamic-therapy-in-eyes-with-chronic-central-serous-chorioretinopathy-results-of-the-pan-american-collaborative-retina-study-pacores-group
#8
Jose A Roca, Lihteh Wu, Jans Fromow-Guerra, Francisco J Rodríguez, Maria H Berrocal, Sergio Rojas, Luiz H Lima, Roberto Gallego-Pinazo, Jay Chhablani, J Fernando Arevalo, David Lozano-Rechy, Martin Serrano
PURPOSE: To compare the functional and anatomical outcomes of eyes with chronic central serous chorioretinopathy treated with yellow micropulse (MP) laser versus half-dose verteporfin photodynamic therapy (PDT). METHODS: This is a multicentre, retrospective comparative study of 92 eyes treated with yellow MP laser (duty cycle of 5%, zero spacing between spots, spot size varied from 100 to 200 µm, power varied from 320 to 660 mW, and the pulse burst duration was 200 ms) and 67 eyes treated with PDT (half-dose verteporfin (3 mg/m2 ) infused over 10 min), followed by laser activation for 83 s...
February 8, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29436399/type-2-choroidal-neovascularisation-in-polypoidal-choroidal-vasculopathy-a-retrospective-case-series
#9
Shuting Liang, Xuan Shi, Philip J Rosenfeld, Xiaoxin Li
BACKGROUND AND OBJECTIVE: To demonstrate the coexistence of polypoidal choroidal vasculopathy (PCV) with type 2 neovascularisation (NV), we used multimodal imaging, including spectral-domain optical coherence tomography angiography (SD-OCTA), to identify both types of lesions in the same eye. STUDY DESIGN: This retrospective case series reviewed patients with PCV diagnosed with indocyanine green angiography (ICGA), fluorescein angiography (FA), SD-OCT and SD-OCTA...
February 7, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29397245/choroidal-osteoma-with-choroidal-excavation-and-associated-neovascular-membrane-an-oct-angiography-study
#10
R Clemente-Tomás, M Cerdà-Ibáñez, A Gargallo-Benedicto, C Marín-Lambíes, L Manfreda-Domínguez, A M Duch-Samper
CLINICAL CASE: A case is presented of a unilateral choroidal osteoma with choroidal excavation and associated neovascular membrane that was studied using OCT-angiography. The OCT and OCT-angiography revealed an area of choroidal excavation and an active neovascular membrane. Three doses of aflibercept were administered to the patient, which stabilised the neovascularisation. DISCUSSION: OCT-angiography was used to analyse the morphology of the superficial vascular network of the osteoma, as well as to monitor the evolution of the neovascular membrane...
May 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29178419/understanding-aneurysmal-type-1-neovascularization-polypoidal-choroidal-vasculopathy-a-lesson-in-the-taxonomy-of-expanded-spectra-a-review
#11
REVIEW
Kunal K Dansingani, Orly Gal-Or, Srinivas R Sadda, Lawrence A Yannuzzi, K Bailey Freund
The term aneurysmal type 1 neovascularization is derived from terminology, which is established in the literature but has fallen out of use. We believe that aneurysmal type 1 neovascularization accurately describes the lesions which define the entity known as polypoidal choroidal vasculopathy (PCV). Over the last three decades, the clinical spectrum of PCV has expanded to recognize the occurrence of the aneurysmal (polypoidal) lesions in different contexts, resulting in a complex and unwieldy taxonomy based sometimes on circumstantial findings rather than mechanistic considerations...
November 25, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29150217/idiopathic-macular-telangiectasia-type-2-prevalence-and-a-morphometric-and-phenotypic-study
#12
R M Bayón-Porras, I Pascual-Camps, C Plaza-Laguardia, R Gallego-Pinazo
OBJECTIVE: Type 2 idiopathic macular telangiectasia (MacTel2) is a rare retinal disease that has still not been well-defined. The aim of the present manuscript is to describe the clinical features by multimodal retinal imaging, to present the functional characteristics, and to estimate the prevalence of the disease. METHODS: A retrospective study was conducted on the 12 eyes of 6 patients with MacTel2. Fundus colour photographs, fundus autofluorescence, fluorescein angiography, optical coherence tomography (OCT), and OCT-angiography were performed and subsequently analysed...
March 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29109897/optic-coherence-angiography-findings-in-type-2-macular-telangiectasia
#13
Hilal Nalcı, Figen Şermet, Sibel Demirel, Emin Özmert
Objectives: To evaluate the vascular changes of idiopathic macular telangiectasia type 2 (MacTel 2) patients with optical coherence tomography angiography (OCTA) and correlate these changes with the findings of spectral domain optical coherence tomography (SD-OCT). Materials and Methods: Simultaneous SD-OCT and OCTA images of 10 eyes of 6 patients who were diagnosed as MacTel 2 in Ankara University Faculty of Medicine, Department of Ophthalmology were obtained and graded according to the OCTA grading system for MacTel 2...
October 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29097668/advanced-glycation-end-products-promote-vegf-expression-and-thus-choroidal-neovascularization-via-cyr61-pi3k-akt-signaling-pathway
#14
Lijuan Sun, Tonglie Huang, Wenqin Xu, Jiaxing Sun, Yang Lv, Yusheng Wang
Choroidal neovascularisation (CNV) causes severe vision loss among old patients, especially those with diabetes. Previously, Cyr61 has been found to play a critical role in the pathogenesis of both AMD and diabetes. In the present study, we found that increased CNV severity together with higher expression of Cyr61 and VEGF in diabetes mice compared with control mice. Moreover, knockdown of Cyr61 decreased CNV severity. In vitro mechanism study revealed that the advanced glycation end products (AGEs) significantly increased the expression of Cyr61 in retinal pigment epithelial (RPE) cells, mimicking the effects of diabetes...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29050001/expression-of-angiogenic-and-inflammatory-factors-in-choroidal-neovascularisation-derived-retinal-pigment-epithelium
#15
Christoph Ehlken, Maria-Magdalena Guichard, Günther Schlunck, Anima D Bühler, Gottfried Martin, Hansjürgen T Agostini
PURPOSE: Anti-angiogenic treatment is well established in the management of exudative age-related macular degeneration (AMD), but not sufficient in all patients. The characterisation of factors driving this chronic disease could serve to identify additional treatment options. The purpose of this study was to assess gene expression patterns and distinct changes in cells derived from surgically extracted choroidal neovascularisation (CNV) membranes. MATERIALS AND METHODS: The expression of >11,000 genes was analysed by means of a microarray in cells cultured from 2 late-stage CNV membranes compared to primary human retinal pigment epithelium (RPE) and ARPE-19 cells...
October 20, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28972027/choroidal-neovascularisation-triggered-multiple-evanescent-white-dot-syndrome-mewds-in-predisposed-eyes
#16
Thibaud Mathis, Benoit Delaunay, Armelle Cahuzac, Vivien Vasseur, Martine Mauget-Faÿsse, Laurent Kodjikian
BACKGROUND: Multiple evanescent white dot syndrome (MEWDS) is an inflammatory disease that can be associated with choroidalneovascularisation (CNV). However, few studies in the literature have described the occurrence of MEWDS in association with CNV. This paper discusses whether CNV can trigger MEWDS in a predisposed eye. METHODS: A retrospective multicentric case series of six eyes in six patients with acute onset of MEWDS and evidence of previous CNV was conducted between January 2015 and January 2017...
September 28, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28939808/novel-pathogenic-mutations-in-c1qtnf5-support-a-dominant-negative-disease-mechanism-in-late-onset-retinal-degeneration
#17
Chloe M Stanton, Shyamanga Borooah, Camilla Drake, Joseph A Marsh, Susan Campbell, Alan Lennon, Dinesh C Soares, Neeru A Vallabh, Jayashree Sahni, Artur V Cideciyan, Baljean Dhillon, Veronique Vitart, Samuel G Jacobson, Alan F Wright, Caroline Hayward
Late-onset retinal degeneration (L-ORD) is a rare autosomal dominant retinal dystrophy, characterised by extensive sub-retinal pigment epithelium (RPE) deposits, RPE atrophy, choroidal neovascularisation and photoreceptor cell death associated with severe visual loss. L-ORD shows striking phenotypic similarities to age-related macular degeneration (AMD), a common and genetically complex disorder, which can lead to misdiagnosis in the early stages. To date, a single missense mutation (S163R) in the C1QTNF5 gene, encoding C1q And Tumor Necrosis Factor Related Protein 5 (C1QTNF5) has been shown to cause L-ORD in a subset of affected families...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28895632/-oct-angiography-in-exudative-amd-with-detachment-of-vascularised-retinal-pigment-epithelium
#18
Frederic Gunnemann, Kai Rothaus, Marie-Louise Farecki, Henrik Faatz, Benedikt Book, Albrecht Lommatzsch, Daniel Pauleikoff
Background The aim of the following extended case study was to analyse whether choroidal neovascularisation (CNV) in vascularised epithelial detachments (PED) in OCT angiography (OCT-A) can be better visualised in OCT-A than in the established angiographic methods during the course of anti-VEGF therapy and if possible used to quantify the CNV size and flow area. These findings were compared with other SD-OCT characteristics of the lesion (PED height, retinal thickness). Patients and Methods 8 patients with PED and associated CNV were diagnosed with multimodal imaging and additionally OCT angiography was performed...
September 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28895628/-exudative-amd-in-oct-angiography
#19
Marie-Louise Farecki, Matthias Gutfleisch, Henrik Faatz, Kai Rothaus, Albrecht Lommatzsch, Daniel Pauleikoff
OCT angiography provides a combination of vascular and structural information. In contrast to conventional fluorescein angiography, there is no need for dye injection to give an image of choroidal neovascularisation. Although there is currently no classification of OCT angiography, different neovascular patterns can be observed, with criteria for activity. In the future, OCT angiography may help us to understand pathophysiological mechanisms and to develop therapeutic strategies.
September 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28855197/optical-coherence-tomography-angiography-reproducibility-of-lesion-size-measurements-in-neovascular-age-related-macular-degeneration-amd
#20
Francesca Amoroso, Alexandra Miere, Oudy Semoun, Camille Jung, Vittorio Capuano, Eric H Souied
PURPOSE: To evaluate the reproducibility and interuser agreement of measurements of choroidal neovascularisation in optical coherence tomography angiography (OCTA). DESIGN: Prospective non-interventional study. METHODS: Consecutive patients, presenting with neovascular age-related macular degeneration (AMD), underwent two sequential OCTA examinations (AngioVue, Optovue, Fremont, California, USA), performed by the same trained examiner. Neovascular lesion area was then measured on both examinations in the choriocapillaris automatic segmentation by two masked readers, using the semiautomated measuring software embedded in the instrument...
August 30, 2017: British Journal of Ophthalmology
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