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Macular oedema

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https://www.readbyqxmd.com/read/28624313/eplerenone-a-new-treatment-for-an-old-problem-retinitis-pigmentosa-with-recalcitrant-macular-edema
#1
R Campos Polo, C Rubio Sánchez, D M García Guisado, M J Díaz Luque
CASE REPORT: The case involves a 35-year-old man, with a history of retinitis pigmentosa, who presented with a bilateral cystoid macular oedema associated with bilateral epiretinal membrane, which was resistant to treatment with oral acetazolamide and intravitreal bevacizumab. The treatment with oral eplerenone was able to improve the visual acuity and macular thickness of this patient. DISCUSSION: A variety of treatments have been proposed for the management of cystoid macular oedema, associated with retinitis pigmentosa, with variable results...
June 14, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28623387/retinal-vascular-geometry-and-6%C3%A2-year-incidence-and-progression-of-diabetic-retinopathy
#2
Carol Yim-Lui Cheung, Charumathi Sabanayagam, Antony Kwan-Pui Law, Neelam Kumari, Daniel Shu-Wei Ting, Gavin Tan, Paul Mitchell, Ching Yu Cheng, Tien Yin Wong
AIMS/HYPOTHESIS: We aimed to examine prospectively the association between a range of retinal vascular geometric variables measured from retinal photographs and the 6 year incidence and progression of diabetic retinopathy. METHODS: We conducted a prospective, population-based cohort study of Asian Malay individuals aged 40-80 years at baseline (n = 3280) who returned for a 6 year follow-up. Retinal vascular geometric variables (tortuosity, branching, fractal dimension, calibre) were measured from baseline retinal photographs using a computer-assisted program (Singapore I Vessel Assessment)...
June 16, 2017: Diabetologia
https://www.readbyqxmd.com/read/28622326/clinical-real-world-results-of-switching-treatment-from-ranibizumab-to-aflibercept-in-patients-with-diabetic-macular-oedema
#3
V E Konidaris, K T Tsaousis, Z Al-Hubeshy, K Pieri, J Deane, T Empeslidis
No abstract text is available yet for this article.
June 16, 2017: Eye
https://www.readbyqxmd.com/read/28619738/fingolimod-associated-macular-oedema
#4
Kirti Madhukar Jasani, Nazar Sharaf, David Rog, Tariq Aslam
No abstract text is available yet for this article.
June 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28602016/long-term-results-of-cataract-surgery-in-patients-with-anterior-uveitis
#5
Ozgur Balta, Gulten Sungur, Mehmet Akif Acar, Mustafa Kosker, Mehmet Yakin, Firdevs Ornek
PURPOSE: This study was aimed to assess the long-term results of phacoemulsification and posterior chamber intraocular lens implantation in patients with anterior uveitis. METHODS: Patients with complicated cataract secondary to anterior uveitis who underwent phacoemulsification and posterior chamber intraocular lens implantation were included in this study. Long-term results and all complications were evaluated throughout the postoperative 4 years. RESULTS: A total of 55 eyes of 48 patients were identified in this study...
June 10, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28594301/orbital-abscess-following-posterior-subtenon-injection-of-triamcinolone-acetonide
#6
Maedbh Rhatigan, Lisa McAnena, Elizabeth McElnea, Paul Connell, Tim Fulcher
Orbital cellulitis is a serious sight threatening and potentially life threatening condition which can be complicated by orbital abscess formation. Posterior subtenon (PST) injection of corticosteroid is commonly used in the treatment of posterior segment inflammation including post-operative macular oedema. We report a case of orbital abscess formation as a late complication of PST triamcinolone acetonide and discuss the presentation, diagnosis and management.
June 2017: Orbit
https://www.readbyqxmd.com/read/28558152/diabetic-macular-oedema-evidence-based-treatment-recommendations-for-asian-countries
#7
REVIEW
Gemmy Cm Cheung, Young Hee Yoon, Lee Jen Chen, Shih Jen Chen, Tara M George, Timothy Yy Lai, Kyu Hyung Park, Sjakon G Tahija, Harvey S Uy, Tien Y Wong
Diabetic macular oedema is the most common cause of diabetic retinopathy-induced vision loss. Efficacy of anti-vascular endothelial growth factor therapy in diabetic macular oedema has been demonstrated in randomized controlled trials. An Asian-specific guideline for diabetic macular oedema treatment is needed as patients in Asia tend to present with far more advanced disease than seen elsewhere in the world. Previous reviews of diabetic macular oedema management lacked a broader assessment of anti-vascular endothelial growth factor treatment choices and newer trials...
May 30, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28556959/exacerbation-of-allopurinol-induced-drug-reaction-with-eosinophilia-and-systemic-symptoms-by-teicoplanin-a-case-report
#8
H Taghvaye Masoumi, M Hadjibabaie, M Zarif-Yeganeh, O Arasteh
WHAT IS KNOWN AND OBJECTIVE: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and potentially life-threatening drug reaction. Allopurinol is one of the most frequently reported drugs accounting for DRESS syndrome development. In contrast to allopurinol, DRESS syndrome induced by teicoplanin has not been reported frequently. CASE DESCRIPTION: A 50-year-old woman was admitted to receive FLAG chemotherapy regimen (fludarabine, cytarabine (high-dose Ara-C), granulocyte colony-stimulating factor) for relapsed acute lymphoblastic leukaemia (ALL) treatment...
May 29, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28556097/diabetic-macular-oedema-clinical-risk-factors-and-emerging-genetic-influences
#9
REVIEW
Ebony Liu, Jamie E Craig, Kathryn Burdon
Diabetic macular oedema is the major cause of visual impairment in type 1 and type 2 diabetes. As type 2 diabetes becomes more prevalent worldwide, the prevalence of diabetic macular oedema is also expected to rise. Current management of diabetic macular oedema is challenging, expensive and not optimal in a subset of patients. Therefore, it is important to increase our understanding of the risk factors involved and develop preventative strategies. While clinical risk factors for diabetic macular oedema have been identified, few studies have addressed potential genetic risk factors...
May 26, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28529319/therapeutic-targeting-of-the-angiopoietin-tie-pathway
#10
REVIEW
Pipsa Saharinen, Lauri Eklund, Kari Alitalo
The endothelial angiopoietin (ANG)-TIE growth factor receptor pathway regulates vascular permeability and pathological vascular remodelling during inflammation, tumour angiogenesis and metastasis. Drugs that target the ANG-TIE pathway are in clinical development for oncological and ophthalmological applications. The aim is to complement current vascular endothelial growth factor (VEGF)-based anti-angiogenic therapies in cancer, wet age-related macular degeneration and macular oedema. The unique function of the ANG-TIE pathway in vascular stabilization also renders this pathway an attractive target in sepsis, organ transplantation, atherosclerosis and vascular complications of diabetes...
May 19, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28516404/screening-for-diabetic-eye-disease-among-samoan-adults-a-pilot-study
#11
V Swetha E Jeganathan, Tim Langford, Lucilla Ah-Ching Sefo, Alex W Hewitt, Nitin Verma
INTRODUCTION: The purpose of this study was to determine the prevalence of diabetic retinopathy in Samoa by piloting a retinal photography screening programme. METHODS: We performed a cross-sectional study of patients with diabetes who presented to the Tupua Tamasese Meaole eye clinic in Apia, Samoa, between May 2011 and September 2011. Study approval was granted by the National Health Service Board of Samoa, the Monash University Human Research Ethics Committee, and the study adhered to the Tenets of the Declaration of Helsinki...
June 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28512919/influence-of-serum-lipids-on-the-incidence-and-progression-of-diabetic-retinopathy-and-macular-oedema-sankara-nethralaya-diabetic-retinopathy-epidemiology-and-molecular-genetics-study-sn-dreams-ii
#12
Sangeetha Srinivasan, Rajiv Raman, Vaitheeswaran Kulothungan, Gayathri Swaminathan, Tarun Sharma
IMPORTANCE: The importance of lipids on incidence and progression of diabetic retinopathy has not been studied in the Indian population. BACKGROUND: To elucidate the influence of serum lipid control on the incidence and progression of diabetic retinopathy and diabetic macular oedema in subjects with type 2 diabetes. DESIGN: population-based longitudinal observational study in a hospital setting. PARTICIPANTS: 890 subjects were examined at baseline and follow-up METHODS: Diabetic retinopathy was graded per Modified Early Treatment Diabetic Retinopathy Study scales; 45°, 4-field dilated stereoscopic digital photography was performed with an additional 30°, 7-field for those who had retinopathy...
May 17, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28508191/investigations-of-severity-level-measurements-for-diabetic-macular-oedema-using-machine-learning-algorithms
#13
S Murugeswari, R Sukanesh
BACKGROUND: The macula is an important part of the human visual system and is responsible for clear and colour vision. Macular oedema happens when fluid and protein deposit on or below the macula of the eye and cause the macula to thicken and swell. Normally, it occurs due to diabetes called diabetic macular oedema. Diabetic macular oedema (DME) is one of the main causes of visual impairment in patients. AIM: The aims of the present study are to detect and localize abnormalities in blood vessels with respect to macula in order to prevent vision loss for the diabetic patients...
May 15, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28495905/long-term-outcomes-of-the-boston-type-i-keratoprosthesis-in-eyes-with-previous-herpes-simplex-virus-keratitis
#14
Melinda Fry, Carolina Aravena, Fei Yu, Jaffer Kattan, Anthony J Aldave
PURPOSE: To report the long-term outcomes of the Boston type I keratoprosthesis (Kpro) in eyes with prior herpes simplex virus (HSV) keratitis. METHODS: Retrospective review of all Kpro procedures performed by a single surgeon from 1 May 2004 to 1 January 2015. RESULTS: 13 of 173 Kpro procedures were performed in 11 eyes with prior HSV keratitis. There was not a significant difference in the percentage of eyes with and without prior HSV keratitis with preoperative (9% vs 8%, p=1...
May 11, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28490797/action-on-diabetic-macular-oedema-achieving-optimal-patient-management-in-treating-visual-impairment-due-to-diabetic-eye-disease
#15
R Gale, P H Scanlon, M Evans, F Ghanchi, Y Yang, G Silvestri, M Freeman, A Maisey, J Napier
This paper identifies best practice recommendations for managing diabetes and sight-threatening diabetic eye disease. The authors provide an update for ophthalmologists and allied healthcare professionals on key aspects of diabetes management, supported by a review of the pertinent literature, and recommend practice principles for optimal patient management in treating visual impairment due to diabetic eye disease. In people with diabetes, early optimal glycaemic control reduces the long-term risk of both microvascular and macrovascular complications...
May 2017: Eye
https://www.readbyqxmd.com/read/28487377/the-uk-diabetic-retinopathy-electronic-medical-record-uk-dr-emr-users-group-report-2-real-world-data-for-the-impact-of-cataract-surgery-on-diabetic-macular-oedema
#16
Alastair K Denniston, Usha Chakravarthy, Haogang Zhu, Aaron Y Lee, David P Crabb, Adnan Tufail, Clare Bailey, Toks Akerele, Sahar Al-Husainy, Christopher Brand, Louise Downey, Alan Fitt, Rehna Khan, Vineeth Kumar, Aires Lobo, Sajjad Mahmood, Kaveri Mandal, Martin Mckibbin, Geeta Menon, Salim Natha, Jong Min Ong, Marie D Tsaloumas, Atul Varma, Elizabeth Wilkinson, Robert L Johnston, Catherine A Egan
AIM: To assess the rate of 'treatment-requiring diabetic macular oedema (DMO)' in eyes for the two  years before and after cataract surgery. METHODS: Multicentre national diabetic retinopathy (DR) database study with anonymised data extraction across 19 centres from an electronic medical record system. INCLUSION CRITERIA: eyes undergoing cataract surgery in patients with diabetes with no history of DMO prior to study start. The minimum dataset included: age, visual acuity (all time-points), injection episodes, timing of cataract surgery and ETDRS grading of retinopathy and maculopathy...
May 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28453510/is-aspirin-associated-with-diabetic-retinopathy-the-singapore-epidemiology-of-eye-disease-seed-study
#17
Yuan Shi, Yih-Chung Tham, Ning Cheung, Jacqueline Chua, Gavin Tan, Paul Mitchell, Jie Jin Wang, Yin Bun Cheung, Ching-Yu Cheng, Tien Yin Wong
BACKGROUND/AIMS: To determine the association between aspirin use and diabetic retinopathy (DR) among persons with diabetes, in a population-based, cross-sectional study. METHODS: Subjects with diabetes aged >40 years from the Singapore Epidemiology of Eye Diseases Study were enrolled in this study. Retinal photographs were graded for DR according to the modified Airlie House classification system. Vision threatening diabetic retinopathy (VTDR) was defined as the presence of severe non-proliferative DR, or proliferative DR, or clinically significant macular oedema...
2017: PloS One
https://www.readbyqxmd.com/read/28452992/influence-of-baseline-diabetic-retinopathy-status-on-initial-anatomical-response-of-intravitreal-ranibizumab-therapy-for-diabetic-macular-oedema
#18
L Nicholson, N V Patrao, J Ramu, C Vazquez-Alfageme, M Muwas, R Rajendram, P G Hykin, S Sivaprasad
PurposeIntraocular vascular endothelial growth factor (VEGF) levels increases with the severity of diabetic retinopathy. Response of diabetic macular oedema (DMO) to ranibizumab is driven by VEGF suppression. We hypothesised that the initial reduction of central macular thickness by ranibizumab should be maximum in severe diabetic retinopathy until the levels of VEGF decreases to the levels observed in eyes with mild retinopathy.MethodsConsecutive patients with centre-involving DMO (central subfield thickness (CSFT)>300 μm) who had three consecutive monthly ranibizumab injections followed by as needed therapy were included...
April 28, 2017: Eye
https://www.readbyqxmd.com/read/28449886/a-novel-postal-based-approach-to-diagnosing-obstructive-sleep-apnoea-in-a-high-risk-population
#19
Benjamin Prudon, Joan Hughes, Sophie West
OBJECTIVE: More than 50% of patients with diabetic macular oedema (DMO) have obstructive sleep apnoea (OSA), but the majority remain undiagnosed. We used a four-channel device (ApneaLink [AL], ResMed, UK) to establish a remote postal-based diagnostic service for patients with DMO. Here we describe our experience. METHODS: Patients with DMO were invited to participate. Interested patients returned a free-post reply slip to the study team, who posted an AL with pictorial and written instructions to them...
May 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28432581/comparison-of-immediate-versus-deferred-intravitreal-bevacizumab-in-macular-oedema-due-to-branch-retinal-vein-occlusion-a-pilot-study
#20
M A Khan, Varakutti Mallika, Dattakiran Joshi
PURPOSE: To compare visual and anatomical recovery of immediate versus deferred intravitreal Bevacizumab for the treatment of macular oedema secondary to branch retinal vein occlusion (BRVO). METHODS: In a pilot study, 40 treatment naïve patients of branch retinal vein occlusion with macular oedema and vision 6/12 or less presenting within one month of onset were randomised into 2 groups (20 each) to receive either immediate intravitreal Bevacizumab or deferred (after 3 months of observation)...
April 21, 2017: International Ophthalmology
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