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https://www.readbyqxmd.com/read/28208899/study-of-variation-in-intraocular-pressure-spike-iop-following-nd-yag-laser-capsulotomy
#1
Niharika K Shetty, Sriya Sridhar
INTRODUCTION: Posterior Capsular Opacifications (PCO) is a frequent complication of cataract surgery following posterior chamber intraocular lens implantation. Nd -Yag laser capsulotomy is the treatment of choice for PCO and is known to be associated with complications like Raised Intraocular Pressure (IOP), Intraocular lens pitting, intraocular lens cracks, cystoid macular oedema, retinal detachment, corneal burns. Raised IOP is the most common complication and prescribing anti-glaucoma drugs post capsulotomy is a common practise...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28205409/diabetic-macular-oedema-what-to-fear-how-to-treat
#2
EDITORIAL
Jakob Grauslund, Søren Leer Blindbaek
No abstract text is available yet for this article.
March 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28203186/real-life-iluvien-fluocinolone-acetonide-case-study-rapid-drying-of-the-macula-and-improved-vision-within-2-years-after-therapy-initiation
#3
Hibba Quhill, Fahd Quhill
IMPORTANCE: A case showing sustained structural and functional responses 2 years after a single treatment with ILUVIEN (0.2 µg/day fluocinolone acetonide, FAc) despite suboptimal responses to ranibizumab. OBSERVATIONS: A 68-year-old female patient with diabetic macular oedema (DME) from type 2 diabetes mellitus was first diagnosed in October 2010 and had a baseline visual acuity (VA) of 46 Early Treatment Diabetic Retinopathy Study (ETDRS) letters in the left eye...
September 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28197794/therapeutic-options-in-refractory-diabetic-macular-oedema
#4
Sanket U Shah, Raj K Maturi
Diabetic macular oedema (DMO) results from alterations of several biochemical pathways in diabetic eyes. Centre-involving DMO is an important cause of visual loss in diabetes. Anti-vascular endothelial growth factor agents are now the mainstay of centre-involving DMO treatment. Oedema that does not achieve optimal response to these agents occurs in a sizeable proportion of eyes and is called refractory or persistent DMO. Management of refractory DMO is challenging. In this paper, the pathophysiology of DMO, and the definitions used in various studies are summarised...
February 15, 2017: Drugs
https://www.readbyqxmd.com/read/28192843/results-of-a-meta-analysis-on-intravitreal-anti-vegf-treatment-of-macular-oedema-secondary-to-branch-retinal-vein-occlusion-brvo
#5
H Gerding
Background In this meta-analysis, the outcome was analysed of intravitreal anti-VEGF (vascular endothelial growth factor) ocular therapy of macular oedema secondary to branch retinal vein occlusion; this was related to baseline and treatment parameters. Material and Methods 36 relevant publications (33 case series) were identified in a MEDLINE-based literature search, which reported on 1,759 treated eyes. Statistical analysis included description of baseline, treatment, and outcome data, linear and non-linear regression and comparison of randomised and non-randomised studies...
February 13, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28185695/radiation-retinopathy-secondary-to-treatment-of-maxillary-sinus-carcinoma-a-dramatic-case
#6
J Galindo-Bocero, S Macías-Franco, S Sánchez-García, M Fonollá-Gil, A García-Alonso
CLINICAL CASE: A 53-year old male presented with visual impairment in right eye after irradiation of right maxillary sinus carcinoma. Funduscopy shows radiation retinopathy: haemorrhages, exudates, macular oedema, and peripheral retinal ischaemia. A poor outcome was achieved despite laser treatment and intravitreal injections of bevacizumab, resulting in evisceration of the affected eye. DISCUSSION: Radiation retinopathy must be considered in any loss of vision after head and neck irradiation...
February 6, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28181178/the-ocular-manifestations-of-drugs-used-to-treat-multiple-sclerosis
#7
REVIEW
Gregory Heath, Archana Airody, Richard Peter Gale
Recent times have seen an increase in the number of options to treat multiple sclerosis. Ocular manifestations of multiple sclerosis are well known to treating physicians; however, the medications used to treat multiple sclerosis can also have ocular side effects. This review article focuses on the ocular manifestations of corticosteroids and disease-modifying agents such as interferon, fingolomod, natalizumab, alemtuzumab and mitoxantron used to treat the disease. The ocular manifestations of multiple sclerosis treatments can be varied depending on the drug used, and include retinopathy, chronic central serous chorioretinopathy, macular oedema, Graves' ophthalmopathy and cortical blindness...
February 8, 2017: Drugs
https://www.readbyqxmd.com/read/28179698/role-of-posterior-sub-tenon-triamcinolone-acetonide-in-patients-of-refractory-macular-oedema
#8
Rana Fahad Ibraheem, Waseem Iqbal
OBJECTIVE: To evaluate the results of posterior sub-tenon triamcinolone acetonide in patients of refractory macular oedema suffering with retinal vascular disorders. METHODS: This quasi-experimental study was conducted at Layton Rahmatulla Benevolent Trust, Lahore, Pakistan, from October 2014 to March 2015, and comprised eyes of patients with refractory macular oedema. The central macular thickness of all patients was determined with ocular coherence tomography before giving injection of 40mg/ml posterior sub-tenon triamcinolone acetonide...
December 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28168827/auckland-cataract-study-2-clinical-outcomes-of-phacoemulsification-cataract-surgery-in-a-public-teaching-hospital
#9
Bia Z Kim, Dipika V Patel, Charles Nj McGhee
IMPORTANCE: A contemporary benchmark for the most common ophthalmic surgery. BACKGROUND: To assess patient characteristics and outcomes of contemporary phacoemulsification cataract surgery in a New Zealand public teaching hospital setting. DESIGN: Prospective observational study. PARTICIPANTS: Consecutive cases (N = 500) of phacoemulsification surgery between April and June 2015. METHODS: An independent observer assessed all clinical and surgical data pre-operatively and 4-6 weeks post-operatively...
February 7, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28139100/dexamethasone-implant-with-fixed-or-individualized-regimen-in-the-treatment-of-diabetic-macular-oedema-six-month-outcomes-of-the-udbasa-study
#10
Valentina Sarao, Daniele Veritti, Claudio Furino, Ermete Giancipoli, Giovanni Alessio, Francesco Boscia, Paolo Lanzetta
PURPOSE: To evaluate a pro re nata administration of Ozurdex(®) implant versus a single administration for treating diabetic macular oedema (DME). METHODS: This exploratory study is designed as a comparative, multicentre, randomized study with a follow-up of 6 months. Patients with DME were assigned to treatment at baseline either with a single Ozurdex(®) implant during the entire six-month follow-up (fixed group) or Ozurdex(®) implant followed by retreatment on an individualized basis (PRN group)...
January 31, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28119290/longitudinal-study-of-retinal-status-using-optical-coherence-tomography-after-acute-onset-endophthalmitis-following-cataract-surgery
#11
Thierry Zhou, Florent Aptel, Alain M Bron, Pierre-Loïc Cornut, Karine Palombi, Gilles Thuret, Frédéric Rouberol, Catherine Creuzot-Garcher, Christophe Chiquet
PURPOSE: To analyse the macula imaged with optical coherence tomography (OCT) in patients treated for acute postcataract endophthalmitis. METHODS: Patients presenting with acute postcataract endophthalmitis were included in this observational and multicentre study from January 2008 to December 2011. We recorded the following OCT data at the 3, 6 and 12-month visits: the central macular thickness, the perifoveal macular thickness, the central foveal point thickness and abnormalities of the outer retina, the macula and vitreoretinal interface...
January 24, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28114697/-strategies-of-intravitreal-injections-with-anti-vegf-pro-re-nata-versus-treat-and-extend
#12
K Hufendiek, A Pielen, C Framme
The goal of this report is to provide a review on different strategies for the use of pro re nata (PRN) and treat and extend (T&E) regimens with intravitreal anti-VEGF agents (bevacizumab, ranibizumab or aflibercept) in patients with retinal diseases such as neovascular AMD, diabetic macular oedema and macular oedema due to retinal vein occlusion. The main focus is to present the effectiveness and visual outcomes of both PRN and T&E regimens in the main pivotal trials and studies based on currently available evidence...
January 23, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28110972/cardiovascular-involvement-in-patients-with-diabetic-macular-oedema-treated-with-intravitreal-ranibizumab-in-routine-clinical-practice
#13
R Díaz-Rodríguez, R Abreu-González, R Dolz-Marco, R Gallego-Pinazo
OBJECTIVE: To determine the cardiovascular events in naïve patients with diabetic macular oedema, before and after being treated with intravitreal ranibizumab. MATERIAL AND METHODS: A retrospective and descriptive study was conducted on patients with diabetic macular oedema and foveal involvement, who started treatment with intravitreal ranibizumab in 2014 in the Hospital Universitario Nuestra Señora de Candelaria and the Hospital Universitario y Politécnico La Fe...
January 19, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28107458/neuropilin-1-involvement-in-choroidal-and-retinal-neovascularisation
#14
Patricia Fernández-Robredo, Senthil Selvam, Michael B Powner, Dawn A Sim, Marcus Fruttiger
PURPOSE: Inhibiting VEGF is the gold standard treatment for neovascular age-related macular degeneration (AMD). It is also effective in preventing retinal oedema and neovascularisation (NV) in diabetic retinopathy (DR) and retinal vein occlusions (RVO). Neuropilin 1 (Nrp1) is a co-receptor for VEGF and many other growth factors, and therefore a possible alternative drug target in intra ocular neovascular disease. Here we assessed choroidal and retinal NV in an inducible, endothelial specific knock out model for Nrp1...
2017: PloS One
https://www.readbyqxmd.com/read/28106887/report-of-12-months-efficacy-and-safety-of-intravitreal-fluocinalone-acetonide-implant-for-the-treatment-of-chronic-diabetic-macular-oedema-a-real-world-result-in-the-united-kingdom
#15
F Alfaqawi, P L Lip, S Elsherbiny, R Chavan, A Mitra, B Mushtaq
: PurposeTo report the 12-months visual and anatomical outcomes of chronic diabetic macular oedema (DMO) treated with ILUVIEN in a real-world clinical practice in a single tertiary referral centre.MethodRetrospective data collection and analysis of consecutive 28 eyes of 23 diabetic patients received ILUVIEN implant for refractory DMO. Standard assessment included visual acuity (VA), central retinal thickness (CRT), slit-lamp biomicroscopy, and Goldmann tonometry for intraocular pressure (IOP) at 1, 6, and 12 months...
January 20, 2017: Eye
https://www.readbyqxmd.com/read/28103831/demographics-of-patients-receiving-intravitreal-anti-vegf-treatment-in-real-world-practice-healthcare-research-data-versus-randomized-controlled-trials
#16
F Ziemssen, N Feltgen, F G Holz, R Guthoff, A Ringwald, T Bertelmann, A Wiedon, C Korb
BACKGROUND: While randomized controlled trials (RCTs) are based on strict inclusion/exclusion criteria, non-interventional studies (NISs) might provide additional information to guide management in patients more representative to the real-world setting. The aim of this study was to compare baseline characteristics of patients receiving intravitreal treatment in the NIS OCEAN with those from published RCTs. METHODS: The ongoing OCEAN study enrolled patients treated with ranibizumab for neovascular age-related macular degeneration (nAMD), diabetic macular oedema (DME) or branch/central retinal vein occlusion (B/CRVO)...
January 19, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28038924/coats-disease-with-macular-oedema-responsive-to-aflibercept-and-argon-laser
#17
M C Guixeres Esteve, A O Pardo Saiz
CLINICAL CASE: A 14 year-old boy with Coats' disease in his right eye, presented with a visual acuity (VA) of 0.1, micro-aneurysms, exudates, a macular oedema of 959 microns, and peripheral telangiectasias. After 12 months follow-up with 6 ranibizumab injections and 3 sessions of argon laser photocoagulation, the macular oedema remained and VA was 0.2. Following 4 aflibercept injections and another 2 laser sessions, he had a good foveal slope and a VA of 0.5, with no recurrences in the last 12 months...
December 27, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28012104/intravitreal-dexamethasone-implant-for-the-treatment-of-cystoid-macular-oedema-associated-with-acute-retinal-necrosis
#18
Parthopratim Dutta Majumder, Jyotirmay Biswas, Asra Ambreen, Rowayda Amin, Zahedur Rahman Pannu, Ahmed Magdy Bedda
BACKGROUND: Acute retinal necrosis is a rare but devastating ocular condition. We report two cases of acute retinal necrosis in immunocompetent patients, complicated by cystoid macular oedema and treated with intravitreal dexamethasone (OZURDEX®) implant. RESULTS: Two patients diagnosed with acute retinal necrosis were treated with intravenous acyclovir. Both of them developed cystoid macular oedema following resolution of viral retinitis. Ocular condition of the first patient was further complicated by central serous chorioretinopathy...
December 2016: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/27983728/safety-and-acceptability-of-an-organic-light-emitting-diode-sleep-mask-as-a-potential-therapy-for-retinal-disease
#19
J N Sahni, G Czanner, T Gutu, S A Taylor, K M Bennett, S M Wuerger, I Grierson, C Murray-Dunning, M N Holland, S P Harding
PurposeThe purpose of the study was to study the effect of an organic light-emitting diode sleep mask on daytime alertness, wellbeing, and retinal structure/function in healthy volunteers and in diabetic macular oedema (DMO).Patients and methodsHealthy volunteers in two groups, 18-30 yrs (A), 50-70 yrs (B) and people with DMO (C) wore masks (504 nm wavelength; 80 cd/m(2) luminance; ≤8 h) nightly for 3 months followed by a 1-month recovery period. Changes from baseline were measured for (means): psychomotor vigilance task (PVT) (number of lapses (NL), response time (RT)), sleep, depression, psychological wellbeing (PW), visual acuity, contrast sensitivity, colour, electrophysiology, microperimetry, and retinal thickness on OCT...
January 2017: Eye
https://www.readbyqxmd.com/read/27974807/long-term-neprilysin-inhibition-implications-for-arnis
#20
REVIEW
Duncan J Campbell
Neprilysin has a major role in both the generation and degradation of bioactive peptides. LCZ696 (valsartan/sacubitril, Entresto), the first of the new ARNI (dual-acting angiotensin-receptor-neprilysin inhibitor) drug class, contains equimolar amounts of valsartan, an angiotensin-receptor blocker, and sacubitril, a prodrug for the neprilysin inhibitor LBQ657. LCZ696 reduced blood pressure more than valsartan alone in patients with hypertension. In the PARADIGM-HF study, LCZ696 was superior to the angiotensin-converting enzyme inhibitor enalapril for the treatment of heart failure with reduced ejection fraction, and LCZ696 was approved by the FDA for this purpose in 2015...
December 15, 2016: Nature Reviews. Cardiology
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