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Macular oedema

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https://www.readbyqxmd.com/read/29776935/ocular-manifestations-of-rickettsia-in-children-common-but-frequently-overlooked
#1
Sara Homem de Melo Marques, Marta Gomes Guerra, Catarina Almeida, Miguel Ribeiro
We review two cases of ocular manifestations of Rickettsia conorii infection in children. A girl who presented unilateral visual loss with focal retinitis and macular oedema and a boy with unilateral central scotoma and bilateral anterior uveitis. Progressive functional and anatomic recovery was observed after oral antibiotics and steroids were initiated.
May 18, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29773271/juvenile-idiopathic-arthritis-associated-uveitis
#2
REVIEW
Ethan S Sen, A V Ramanan
Juvenile idiopathic arthritis (JIA) is the commonest rheumatic disease in children and JIA-associated uveitis its most frequent extra-articular manifestation. The uveitis is potentially sight-threatening and thus carries a considerable risk of morbidity with associated reduction in quality of life. The commonest form of uveitis seen in association with JIA is chronic anterior uveitis, which is almost always asymptomatic in the initial stages. Therefore, screening for JIA-associated uveitis in at-risk patients is essential...
August 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29739028/-topical-corticosteroids-and-non-steroidal-anti-inflammatory-drugs-in-the-therapy-of-non-infectious-uveitis
#3
Deshka Doycheva, Christoph Deuter, Rafael Grajewski
Topical corticosteroids are effective anti-inflammatory drugs in the treatment of anterior uveitis. The intraocular efficacy of topical corticosteroids mostly depends on their intraocular permeability through the cornea. Lipophile derivatives such as dexamethasone and prednisolone acetate penetrate better into the anterior chamber than hydrophilic derivatives. Prednisolone acetate 1% is the first choice in the therapy of patients with anterior uveitis. Loteprednole and fluorometholone have a slightly weaker anti-inflammatory effect, but they induce less elevation of intraocular pressure and might be helpful in the treatment of patients with steroid response...
May 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29706600/retrospective-cohort-study-exploring-whether-an-association-exists-between-spatial-distribution-of-cystoid-spaces-in-cystoid-macular-oedema-secondary-to-retinitis-pigmentosa-and-response-to-treatment-with-carbonic-anhydrase-inhibitors
#4
Stacey A Strong, Nashila Hirji, Ana Quartilho, Angelos Kalitzeos, Michel Michaelides
BACKGROUND: Carbonic anhydrase inhibitors (CAIs) are frequently used as an initial step to treat retinitis pigmentosa-associated cystoid macular oedema (RP-CMO). Interestingly, it has been postulated that CAIs might reduce outer nuclear layer (ONL) fluid more effectively than inner nuclear layer (INL) fluid due to better access to retinal pigment epithelium basolateral membrane than neurosensory retina. This retrospective cohort study explores if an association between spatial distribution of cystoid spaces in RP-CMO and CAI response exists...
April 29, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29705892/the-ophthalmic-diagnosis-and-management-of-four-siblings-with-werner-syndrome
#5
C Lyons, D Gallagher, T McSwiney, E McElnea, F Kinsella
INTRODUCTION: Werner syndrome is a rare autosomal recessive disorder caused by mutations in the Werner syndrome WRN gene, on chromosome 8. Those affected manifest early the features of ageing. DISCUSSION: Cataract surgery is prone to post-operative complications in those with Werner syndrome. The development of cystoid macular oedema (CMO) is likely multifactorial. Patients with WS have diabetes mellitus type 2 which can contribute to macular oedema. There is a deposition of abnormal WRN proteins in the macula which also predisposes to macular oedema...
April 28, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29699981/microaneurysm-turnover-is-a-predictor-of-diabetic-retinopathy-progression
#6
Rajeev K R Pappuru, Luísa Ribeiro, Conceição Lobo, Dalila Alves, José Cunha-Vaz
AIM: To analyse retinopathy phenotypes and microaneurysm (MA) turnover in mild non-proliferative diabetic retinopathy (NPDR) as predictors of progression to diabetic central-involved macular oedema (CIMO) in patients with type 2 diabetes mellitus (DM) in two different ethnic populations. METHODS: 205 patients with type 2 DM and mild NPDR were followed in a prospective observational study for 2 years or until development of CIMO, in two centres from different regions of the world...
April 26, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29699979/changes-in-retinal-ischaemic-index-correlate-with-recalcitrant-macular-oedema-in-retinal-vein-occlusion-wave-study
#7
Soonil Kwon, Charles Clifton Wykoff, David M Brown, Jano van Hemert, Wenying Fan, SriniVas R Sadda
AIM: To evaluate changes in the ischaemic index (ISI) after targeted retinal photocoagulation (TRP) and to investigate the correlation between these changes and macular oedema (ME). METHOD: Twenty-four eyes of 24 patients with retinal vein occlusion (RVO) with recurrent ME were included. Ultra-widefield fluorescein angiography (UWFFA; Optos 200Tx) was obtained at baseline and every 4 months. The regions of retinal non-perfusion and the total gradable retina were manually segmented on UWFFA images for calculating the global ISI...
April 26, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29696809/a-noninterventional-study-to-monitor-patients-with-diabetic-macular-oedema-starting-treatment-with-ranibizumab-polaris
#8
Jana Stefanickova, Jose Cunha-Vaz, Michael Ulbig, Ian Pearce, Alvaro Fernández-Vega Sanz, Panagiotis Theodossiadis, Laurent Kodjikian, Alexander Izmailov, Dominic Muston, Zdravko Vassilev, Benedicte Lamotte, Claudia Tückmantel, Sabine Friedl, Andreas Altemark, Hans-Jörg Schwarz, Todd Katz
PURPOSE: Antivascular endothelial growth factor agents are increasingly used in diabetic macular oedema (DME); however, there are few studies exploring their use in DME in real-world settings. METHODS: POLARIS was a noninterventional, multicentre study to monitor 12-month outcomes in patients starting ranibizumab treatment in routine practices. The primary outcome was mean change in visual acuity (VA) from baseline to month 12 (last observation carried forward approach)...
April 25, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29687595/the-area-of-fixation-covaries-with-short-term-changes-in-visual-acuity-after-anti-vascular-endothelial-growth-factor-treatment-in-patients-with-diabetic-macular-oedema
#9
Nanna Staehr Jakobsen, Dorte Ancher Larsen, Toke Bek
PURPOSE: Diabetic maculopathy can be treated with intravitreal injection of vascular endothelial growth factor (VEGF) inhibitors. However, the therapy is not effective in all patients, and it would be desirable to have parameters for differentiating patients who will benefit from treatment from those who will not. Retinal fixation has been shown to be impaired in patients with low visual acuity (VA) secondary to macular disease, but the changes in fixational eye movements after anti-VEGF treatment for diabetic maculopathy have not been investigated...
April 24, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29682912/diabetic-macular-oedema-under-represented-in-the-genetic-analysis-of-diabetic-retinopathy
#10
REVIEW
Suzanne Broadgate, Christine Kiire, Stephanie Halford, Victor Chong
Diabetic retinopathy, a complication of both type 1 and type 2 diabetes, is a complex disease and is one of the leading causes of blindness in adults worldwide. It can be divided into distinct subclasses, one of which is diabetic macular oedema. Diabetic macular oedema can occur at any time in diabetic retinopathy and is the most common cause of vision loss in patients with type 2 diabetes. The purpose of this review is to summarize the large number of genetic association studies that have been performed in cohorts of patients with type 2 diabetes and published in English-language journals up to February 2017...
April 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29675844/delivery-of-therapeutics-for-deep-seated-ocular-conditions-status-quo
#11
REVIEW
Hubert Nguyen, Shawn Eng, Thanh Ngo, Crispin R Dass
OBJECTIVES: There is a need for research into designing effective pharmaceutical systems for delivering therapeutic drugs to the posterior of the eye for glaucoma-related pathology, macular degeneration, diabetic retinopathy, macular oedema, retinitis and choroiditis. Conventionally, eye drops have been extensively utilised for topical drug delivery to the anterior segment of the eye, but are less effective for delivery of therapeutics to the back of the eye due to significant barriers hampering drug penetration into the target intraocular tissue...
April 19, 2018: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29669176/anti-vascular-endothelial-growth-factor-combined-with-intravitreal-steroids-for-diabetic-macular-oedema
#12
REVIEW
Hemal Mehta, Charles Hennings, Mark C Gillies, Vuong Nguyen, Anna Campain, Samantha Fraser-Bell
BACKGROUND: The combination of steroid and anti-vascular endothelial growth factor (VEGF) intravitreal therapeutic agents could potentially have synergistic effects for treating diabetic macular oedema (DMO). On the one hand, if combined treatment is more effective than monotherapy, there would be significant implications for improving patient outcomes. Conversely, if there is no added benefit of combination therapy, then people could be potentially exposed to unnecessary local or systemic side effects...
April 18, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29666084/multiple-myeloma-masquerading-as-diabetic-macular-oedema
#13
Kavitha Rao, Hemanth Murthy, N S Muralidhar, Padmaja Kumari Rani
A 58-year-old man, a known diabetic and hypertensive for 5 years was presented to us with a drop in reading vision in both eyes of 2 months duration. His best-corrected visual acuity was 6/24, N36 in both eyes. Fundus findings revealed moderate non-proliferative diabetic retinopathy with bilateral diffuse macular oedema. When conventional therapy with intravitreal ranibizumab did not alter the clinical picture, we looked into the differential diagnosis of bilateral persistent macular detachments and investigated further...
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29657976/efficacy-of-additional-topical-betamethasone-in-persistent-cystoid-macular-oedema-after-carbonic-anhydrase-inhibitor-treatments-in-retinitis-pigmentosa
#14
Shohei Kitahata, Yasuhiko Hirami, Seiji Takagi, Cody Kime, Masashi Fujihara, Yasuo Kurimoto, Masayo Takahashi
Objective: We investigated the efficacy of additional topical betamethasone in persistent cystoid macular oedema (CMO) after carbonic anhydrase inhibitors (CAIs) therapy. Methods and analysis: This retrospective cohort study included 16 eyes of 10 patients with retinitis pigmentosa (RP). All patients were previously administered CAI for at least 3 months to treat CMO secondary to RP and lacking an effective reduction (≥11%) of central foveal thickness (CFT)...
2018: BMJ Open Ophthalmology
https://www.readbyqxmd.com/read/29618836/outcomes-of-sphincterotomy-for-small-pupil-phacoemulsification
#15
Joanne W Y Goh, Rhys Harrison, Shokufeh Tavassoli, Derek M Tole
PURPOSE: Sphincterotomy, an alternative to iris hooks or pupil stretching, is a technique that can aid in small pupil phacoemulsification. The incidence of post-operative complications of this procedure, however, has not been studied. Our study evaluates the post-operative outcomes of phacoemulsification surgery with adjunctive pupillary sphincterotomy. METHODS: We conducted a retrospective review of case notes and Medisoft ® electronic record of patients that had undergone simultaneous sphincterotomy, phacoemulsification and intraocular lens (IOL) implantation by a single surgeon between March 2012 and February 2017...
April 5, 2018: Eye
https://www.readbyqxmd.com/read/29576505/siponimod-versus-placebo-in-secondary-progressive-multiple-sclerosis-expand-a-double-blind-randomised-phase-3-study
#16
Ludwig Kappos, Amit Bar-Or, Bruce A C Cree, Robert J Fox, Gavin Giovannoni, Ralf Gold, Patrick Vermersch, Douglas L Arnold, Sophie Arnould, Tatiana Scherz, Christian Wolf, Erik Wallström, Frank Dahlke
BACKGROUND: No treatment has consistently shown efficacy in slowing disability progression in patients with secondary progressive multiple sclerosis (SPMS). We assessed the effect of siponimod, a selective sphingosine 1-phosphate (S1P) receptor1,5 modulator, on disability progression in patients with SPMS. METHODS: This event-driven and exposure-driven, double-blind, phase 3 trial was done at 292 hospital clinics and specialised multiple sclerosis centres in 31 countries...
March 22, 2018: Lancet
https://www.readbyqxmd.com/read/29567794/early-oct-angiography-changes-of-type-1-cnv-in-exudative-amd-treated-with-anti-vegf
#17
Elisabetta Pilotto, Luisa Frizziero, Anna Rita Daniele, Enrica Convento, Evelyn Longhin, Francesca Guidolin, Raffaele Parrozzani, Fabiano Cavarzeran, Edoardo Midena
AIMS: To investigate, with optical coherence tomography angiography (OCTA), short-term changes of type 1 choroidal neovascularisation (CNV), secondary to exudative age-related macular degeneration, after anti-vascular endothelial growth factor (VEGF) treatment. METHODS: Patients affected by type 1 CNV treated with intravitreal anti-VEGF were consecutively enrolled. All patients underwent OCTA examination before and 48 hours after anti-VEGF treatment. Quantitative and qualitative vascular and morphological macular changes were evaluated...
March 22, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29566387/spectral-domain-optical-coherence-tomography-driven-treat-and-extend-and-pro-re-nata-regimen-in-patients-with-macular-oedema-due-to-retinal-vein-occlusion-24-month-evaluation-and-outcome-predictors
#18
Maria-Magdalena Guichard, Anton R Xavier, Cengiz Türksever, Christian Pruente, Katja Hatz
PURPOSE: To analyse the efficacy and outcome predictors of ranibizumab using a spectral-domain optical coherence tomography (SD-OCT)-driven treat-and-extend regimen (TER) versus SD-OCT-driven pro re nata regimen (PRN) in patients with cystoid macular oedema (CME) due to branch or central retinal vein occlusion (BRVO, CRVO). METHODS: Retrospective, consecutive case series. Evaluation included best corrected visual acuity (BCVA), morphological parameters on SD-OCT, and treatment frequency...
March 22, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29563110/clinical-features-of-patients-with-diabetic-anterior-uveitis
#19
Takayo Watanabe, Hiroshi Keino, Kyoko Nakayama, Wakako Taki, Nariaki Echizen, Annabelle A Okada
AIM: To describe clinical features and outcomes of new-onset anterior uveitis associated with poorly controlled or undiagnosed diabetes mellitus. METHODS: Retrospective analysis of 25 eyes of 18 patients (14 men, 4 women; mean age 44 years) who presented between December 2001 and October 2016 to the Kyorin Eye Center. RESULTS: Ocular findings at presentation included posterior synechiae (15 eyes, 60%), anterior chamber fibrin (13 eyes, 52%), keratic precipitates (10 eyes, 40%), Descemet membrane folds (7 eyes, 28%) and hypopyon (3 eyes, 12%)...
March 21, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29556012/-statins-in-retinal-disease
#20
REVIEW
Ahmed Al-Janabi, Sue Lightman, Oren Tomkins-Netzer
Statins are known for their blood cholesterol-lowering effect and are widely used in patients with cardiovascular and metabolic diseases. Research over the past three decades shows that statins have diverse effects on different pathophysiological pathways involved in angiogenesis, inflammation, apoptosis, and anti-oxidation, leading to new therapeutic options. Recently, statins have attracted considerable attention for their immunomodulatory effect. Since immune reactivity has been implicated in a number of retinal diseases, such as uveitis, age-related macular degeneration (AMD) and diabetic retinopathy, there is now a growing body of evidence supporting the beneficial effects of statins in these retinopathies...
March 20, 2018: Eye
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