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https://www.readbyqxmd.com/read/29334627/testosterone-dhea-and-dhea-s-in-patients-with-schizophrenia-a-systematic-review-and-meta-analysis
#1
REVIEW
Błażej Misiak, Dorota Frydecka, Olga Loska, Ahmed A Moustafa, Jerzy Samochowiec, Justyna Kasznia, Bartłomiej Stańczykiewicz
Neuroactive steroids, including testosterone, dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) might play an important role in the pathophysiology of schizophrenia. Therefore, we performed a systematic review and meta-analysis of studies comparing the levels of testosterone, DHEA and DHEA-S in patients with schizophrenia and healthy controls. We searched electronic databases from their inception until Oct 29, 2017. Effect size (ES) estimates were calculated as Hedges' g. Data analysis was performed using random-effects models...
January 9, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29332928/optical-coherence-tomography-for-precision-brain-imaging-neurosurgical-guidance-and-minimally-invasive-theranostics
#2
Yingwei Fan, Yan Xia, Xinran Zhang, Yu Sun, Jie Tang, Liwei Zhang, Hongen Liao
This review focuses on optical coherence tomography (OCT)-based neurosurgical application for imaging and treatment of brain tumors. OCT has emerged as one of the most innovative and successful translational biomedical-diagnostic techniques. It is a useful imaging tool for noninvasive, in vivo, in situ and real-time imaging in soft biological tissues, such as brain tumor imaging. OCT can detect the structure of biological tissue in a micrometer scale, and functional OCT has some clinical researches and applications, such as nerve fiber tracts and neurovascular imaging...
January 15, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29332908/optical-coherence-tomography-guidance-in-management-of-acute-coronary-syndrome-caused-by-plaque-erosion
#3
Haibo Jia, Takashi Kubo, Takashi Akasaka, Bo Yu
For several decades, most physicians have believed that acute coronary syndrome (ACS) is caused by coronary thrombosis resulting from rupture of vulnerable plaque characterized by a thin fibrous cap overlying a large necrotic core and massive inflammatory cell infiltration. However, nearly one-third of ACS cases are caused by plaque erosion characterized by intact fibrous cap, less or absent necrotic core, less inflammation, and large lumen. Because of the limitations of current imaging modalities, including angiography and intravascular ultrasound, the importance of plaque erosion as a cause of acute coronary events is less well known...
January 13, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29332307/scaffold-thrombosis-following-implantation-of-the-absorb-bvs-in-routine-clinical-practice-insight-into-possible-mechanisms-from-optical-coherence-tomography
#4
Robin P Kraak, Alexandre H Kajita, Hector M Garcia-Garcia, Jose P S Henriques, Jan J Piek, E Karin Arkenbout, René J van der Schaaf, Jan G P Tijssen, Robbert J de Winter, Joanna J Wykrzykowska
OBJECTIVES: To identify potential underlying mechanisms of early and (very) late scaffold thrombosis (ScT) by optical coherence tomography (OCT), in a frame-by-frame analysis. BACKGROUND: The absorb scaffold is associated with an increased risk of ScT compared with metallic stents. Several potential causes of bioresorbable ScT have been identified, however the precise etiology still remains unclear. METHODS: Between February 2013 and February 2016, 13 patients presenting with definite ScT underwent OCT imaging...
January 14, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29332249/correlation-of-flow-density-as-measured-using-optical-coherence-tomography-angiography-with-structural-and-functional-parameters-in-glaucoma-patients
#5
Maged Alnawaiseh, Larissa Lahme, Viktoria Müller, André Rosentreter, Nicole Eter
PURPOSE: To evaluate the correlation between flow density, as measured by optical coherence tomography angiography (OCTA), and structural and functional parameters in patients with open-angle glaucoma. METHODS: Thirty-four eyes of 34 patients with open-angle glaucoma and 35 eyes of 35 healthy subjects were prospectively included in this study. OCTA was performed using RTVue XR Avanti with AngioVue. The macula was imaged with a 3 × 3 mm scan and the optic nerve head (ONH) with a 4...
January 13, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29332119/autofluorescence-of-skin-advanced-glycation-end-products-as-a-risk-factor-for-open-angle-glaucoma-the-alienor-study
#6
Cedric Schweitzer, Audrey Cougnard-Gregoire, Vincent Rigalleau, Jean-Francois Dartigues, Florence Malet, Marie-Benedicte Rougier, Marie-Noelle Delyfer, Catherine Helmer, Jean-Francois Korobelnik, Cecile Delcourt
Purpose: To analyze the association between skin autofluorescence (sAF), estimating tissue accumulation of advanced glycation end-products (AGEs), and open angle glaucoma (OAG) in an elderly population. Methods: The Antioxydants, Lipides Essentiels, Nutrition and maladies OculaiRes (ALIENOR) study is an on-going epidemiologic population-based study on age-related eye diseases. In 2009 to 2010, 624 subjects, aged 74 years or older, were recruited. All subjects underwent a complete eye examination, including optic disc color photography and spectral-domain optical coherence tomography (SD-OCT) examination...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29332093/structure-function-correlation-in-hemianopic-vision-loss-in-children-aged-3-6-years-using-oct-and-svop-and-comparison-with-adult-eyes
#7
Wadim Bowl, Robert Knobloch, Silke Schweinfurth, Kerstin Holve, Knut Stieger, Birgit Lorenz
PURPOSE: To correlate visual field assessment with saccadic vector optokinetic perimetry (SVOP) in children with ganglion cell loss due to anterior pathway pathologies resulting in hemianopic visual field defects measured with optical coherence tomography (OCT). METHODS: 5 young (aged 3-6 years) and 5 adult patients with hemianopia, 10 healthy preschoolers (mean age 4.4 years), and 10 healthy adults (mean age 25.3 years) were tested with SVOP and OCT (focusing on the ganglion cell layer, GCL+)...
January 13, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29331909/linking-composition-of-extracellular-polymeric-substances-eps-to-the-physical-structure-and-hydraulic-resistance-of-membrane-biofilms
#8
Peter Desmond, James P Best, Eberhard Morgenroth, Nicolas Derlon
The effect of extracellular polymeric substances (EPS) on the meso-scale physical structure and hydraulic resistance of membrane biofilms during gravity driven membrane (GDM) filtration was investigated. Biofilms were developed on the surface of ultrafiltration membranes during dead-end filtration at ultra-low pressure (70 mbar). Biofilm EPS composition (total protein, polysaccharide and eDNA) was manipulated by growing biofilms under contrasting nutrient conditions. Nutrient conditions consisted of (i) a nutrient enriched condition with a nutrient ratio of 100:30:10 (C: N: P), (ii) a phosphorus limitation (C: N: P ratio: 100:30:0), and (iii) a nitrogen limitation (C: N: P ratio: 100:0:10)...
December 27, 2017: Water Research
https://www.readbyqxmd.com/read/29331556/polypoidal-choroidal-vasculopathy-definition-pathogenesis-diagnosis-and-management
#9
REVIEW
Chui Ming Gemmy Cheung, Timothy Y Y Lai, Paisan Ruamviboonsuk, Shih-Jen Chen, Youxin Chen, K Bailey Freund, Fomi Gomi, Adrian H Koh, Won-Ki Lee, Tien Yin Wong
Polypoidal choroidal vasculopathy (PCV) is an age-related macular degeneration (AMD) subtype and is seen particularly in Asians. Previous studies have suggested disparity in response to intravitreal injections of anti-vascular endothelial growth factor (VEGF) agents between PCV and typical AMD, and thus, the preferred treatment for PCV has remained unclear. Recent research has provided novel insights into the pathogenesis of PCV, and imaging studies based on OCT suggest that PCV belongs to a spectrum of conditions characterized by pachychoroid, in which disturbance in the choroidal circulation seems to be central to its pathogenesis...
January 10, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29329763/efficacy-and-safety-of-varenicline-for-smoking-cessation-in-people-living-with-hiv-in-france-anrs-144-inter-activ-a-randomised-controlled-phase-3-clinical-trial
#10
Patrick Mercié, Julie Arsandaux, Christine Katlama, Samuel Ferret, Aurélie Beuscart, Christian Spadone, Claudine Duvivier, Jacques Reynes, Nathalie Wirth, Laetitia Moinot, Antoine Bénard, David Zucman, Xavier Duval, Jean-Michel Molina, Bruno Spire, Catherine Fagard, Geneviève Chêne
BACKGROUND: Tobacco smoking is common in people living with HIV, but high-quality evidence on interventions for smoking cessation is not available in this population. We aimed to assess the efficacy and safety of varenicline with counselling to aid smoking cessation in people living with HIV. METHODS: The ANRS 144 Inter-ACTIV randomised, parallel, double-blind, multicentre, placebo-controlled phase 3 trial was done at 30 clinical hospital sites in France. People living with HIV who had smoked at least ten cigarettes per day for 1 year or longer, were motivated to stop smoking, were not dependent on another psychoactive substance, and had no history of depression or suicide attempt were eligible...
January 9, 2018: Lancet HIV
https://www.readbyqxmd.com/read/29329346/evaluation-of-bloodstream-infections-clostridium-difficile-infections-and-gut-microbiota-in-pediatric-oncology-patients
#11
Bryan T Nycz, Samuel R Dominguez, Deborah Friedman, Joanne M Hilden, Diana Ir, Charles E Robertson, Daniel N Frank
Bloodstream infections (BSI) and Clostridium difficile infections (CDI) in pediatric oncology/hematology/bone marrow transplant (BMT) populations are associated with significant morbidity and mortality. The objective of this study was to explore possible associations between altered microbiome composition and the occurrence of BSI and CDI in a cohort of pediatric oncology patients. Stool samples were collected from all patients admitted to the pediatric oncology floor from Oct.-Dec. 2012. Bacterial profiles from patient stools were determined by bacterial 16S rRNA gene profiling...
2018: PloS One
https://www.readbyqxmd.com/read/29329141/precision-of-optic-nerve-head-and-retinal-nerve-fiber-layer-parameter-measurements-by-spectral-domain-optical-coherence-tomography
#12
Laura M Schrems-Hoesl, Wolfgang A Schrems, Robert Laemmer, Friedrich E Kruse, Christian Y Mardin
PURPOSE: The aim of this study was to assess the repeatability and reproducibility (R&R) of Bruch's Membrane Opening - based on Minimum Rim Width (BMO-MRW), Minimum Rim Area (BMO-MRA) and peripapillary retinal nerve fiber layer thickness (RNFLT) with the Spectralis OCT (Heidelberg Engineering) for normal and glaucoma subjects. Precise measurement of these parameters can support detection of structural glaucomatous damage and progression. METHODS: This cross-sectional study included 16 healthy controls and 16 patients with glaucoma...
January 11, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29329138/relationship-of-macular-thickness-and-function-to-optical-microangiography-measurements-in-glaucoma
#13
Harsha L Rao, Mohammed Riyazuddin, Srilakshmi Dasari, Narendra K Puttaiah, Zia S Pradhan, Robert N Weinreb, Kaweh Mansouri, Carroll A B Webers
PURPOSE: To evaluate the relationship between macular optical microangiography (OMAG), ganglion cell-inner plexiform layer (GCIPL) thickness and visual sensitivity measurements of different macular sectors in primary open angle glaucoma (POAG). METHODS: In a cross-sectional study, 39 eyes of 26 POAG patients underwent OCT imaging and 10-2 visual field examination of the macula in the same session. Linear regression models were used to evaluate the relationships between OMAG, GCIPL thickness and visual sensitivity measurements in different macular sectors...
January 11, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29329137/macular-and-multifocal-perg-and-fd-oct-in-pre-perimetric-and-hemifield-loss-glaucoma
#14
André Carvalho Kreuz, Carlos Gustavo de Moraes, Marcelo Hatanaka, Maria Kiyoko Oyamada, Mario L R Monteiro
PURPOSE: To evaluate the ability of macular and multifocal (mf) pattern electroretinogram (PERG) to differentiate pre-perimetric glaucoma (PG) and glaucoma with hemifield loss (GHL) from controls, to compare the discrimination ability of PERG and fourier-domain optical coherence tomography (fdOCT), and to assess the relationship between measurements. METHODS: Standard automated perimetry, [1] steady-state and transient PERG and mfPERG measurements were obtained from PG (n=14, 24 eyes), GHL (n=5, 7 eyes) and controls (n=19, 22 eyes)...
January 11, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29327033/disorganization-of-inner-retina-and-outer-retinal-morphology-in-diabetic-macular-edema
#15
Radha Das, Gareth Spence, Ruth E Hogg, Michael Stevenson, Usha Chakravarthy
Importance: In diabetic macular edema (DME), identification of baseline markers on spectral-domain optical coherence tomography (SD-OCT) and their association with severity of diabetic retinopathy (DR) might aid in disease management and the design of future trials. Objective: To examine associations between DR severity, retinal morphology on SD-OCT, and visual acuity in participants with DME. Design, Setting, and Participants: This cross-sectional observational case series was conducted at a single tertiary care referral center...
January 11, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29327010/dna-methylation-assay-using-droplet-based-dna-melting-curve-analysis
#16
F-W Liu, H-F Liao, S-P Lin, Y-W Lu
DNA methylation is an epigenetic regulation of gene expression, which has drawn great attention in biomedical research due to its association with various diseases. A robust, inexpensive platform to detect and quantify the methylation status in a specific genomic region is necessary. In this study, an on-chip analytical technique of cytosine methylation with droplets in a microchannel is proposed. Genomic DNA samples are encapsulated into a series of droplets and transported through a detection region, where a stable temperature gradient is created...
January 12, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29326854/macular-buckling-surgery-for-retinal-detachment-associated-with-macular-hole-in-high-myopia-eye
#17
Kenan Sönmez, Ali Keleş
A 68-year-old woman presented to our clinic with a 1-month history of central scotoma and visual loss in her right eye. The best corrected visual acuity (BCVA) was hand motion in her right eye. Fundus examination showed myopic chorioretinal degeneration in association with posterior staphyloma and the retina was slightly elevated throughout the macula. Optical coherence tomography (OCT) revealed retinal detachment involving the posterior pole with a macular hole and staphyloma. The patient underwent pars plana vitrectomy, internal limiting membrane peeling, macular buckling, and perfluoropropane gas tamponade...
December 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29326849/spectral-domain-optical-coherence-tomography-findings-in-carotid-artery-disease
#18
Akın Çakır, Eyüp Düzgün, Serkan Demir, Yavuz Çakır, Melih Hamdi Ünal
Objectives: To evaluate the effect of carotid artery disease on retinal morphology by means of spectral domain optical coherence tomography (SD-OCT). Materials and Methods: We examined 23 eyes with internal carotid artery (ICA) stenosis and 24 age- and gender-matched healthy eyes as a control group in this prospective, case-control study. Compherensive ophthalmic examination and SD-OCT scan were performed to all the patients. The average RNFL and macular thicknesses (MT) in the nine macular ETDRS areas were the major OCT measurements for our study...
December 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29326030/patient-reported-outcomes-following-abiraterone-acetate-plus-prednisone-added-to-androgen-deprivation-therapy-in-patients-with-newly-diagnosed-metastatic-castration-naive-prostate-cancer-latitude-an-international-randomised-phase-3-trial
#19
Kim N Chi, Andrew Protheroe, Alfredo Rodríguez-Antolín, Gaetano Facchini, Henrik Suttman, Nobuaki Matsubara, Zhangqun Ye, Bhumsuk Keam, Ronaldo Damião, Tracy Li, Kelly McQuarrie, Bin Jia, Peter De Porre, Jason Martin, Mary B Todd, Karim Fizazi
BACKGROUND: In the LATITUDE trial, addition of abiraterone acetate plus prednisone to androgen deprivation therapy (ADT) improved overall survival compared with placebos plus ADT in patients with newly diagnosed, high-risk, metastatic castration-naive prostate cancer. Understanding the effects of treatments on patient-reported outcomes (PROs) and health-related quality of life (HRQOL) is important for treatment decisions; therefore we aimed to analyse the effects of ADT plus abiraterone acetate and prednisone versus ADT plus placebos on PROs and HRQOL in patients in the LATITUDE study...
January 8, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29325960/results-of-biopsy-proven-sellar-germ-cell-tumors-nine-years-experience-in-a-single-center
#20
Yi Zhang, Huijuan Zhu, Kan Deng, Wenbin Ma, Yu Wang, Jian Sun, Xin Lian, Hui Pan, Renzhi Wang, Yong Yao
BACKGROUND: The biopsy is recognized as the most accurate method to determine the histological characterization of sellar germ cell tumors. It is very difficult to evaluate the prognosis before histological confirmation. OBJECTIVES: This study aimed to evaluate the independent prognostic risk factors of patients with sellar germ cell tumors (GCTs). METHODS: From January 2008 to December 2015, 61 patients who were histologically diagnosed as sellar GCTs did follow-ups and were included in this retrospective study...
January 8, 2018: World Neurosurgery
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