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MicroRNA cardiac fibrosis

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https://www.readbyqxmd.com/read/28407626/exogenous-mirna-146a-enhances-the-therapeutic-efficacy-of-human-mesenchymal-stem-cells-by-increasing-vascular-endothelial-growth-factor-secretion-in-the-ischemia-reperfusion-injured-heart
#1
Hyang-Hee Seo, Se-Yeon Lee, Chang Youn Lee, Ran Kim, Pilseog Kim, Sekyung Oh, Hojin Lee, Min Young Lee, Jongmin Kim, Lark Kyun Kim, Ki-Chul Hwang, Woochul Chang
Adult stem cells have been studied as a promising therapeutic modality for the functional restoration of the damaged heart. In the present study, a strategy for enhancing the angiogenic efficacy of human mesenchymal stem cells (hMSCs) using micro-RNA was examined. We investigated whether micro-RNA-146a (miR-146a) influences the secretion of vascular endothelial growth factor (VEGF) and angiogenesis of MSCs. Our data indicated that miR-146a-transfected hMSCs (hMSCmiR-146a) decreased the expression of neurofibromin 2, an inhibitor of p21-activated kinase-1 (PAK1)...
April 14, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28368454/role-and-regulation-of-micrornas-in-aldosterone-mediated-cardiac-injury-and-dysfunction-in-male-rats
#2
Jana P Ball, Maryam Syed, Rodrigo O Marañon, Michael E Hall, Roshan Kc, Jane F Reckelhoff, Licy L Yanes Cardozo, Damian G Romero
Primary aldosteronism is characterized by excess aldosterone (ALDO) secretion independent of the renin-angiotensin system and accounts for ∼10% of hypertensive patients. Excess ALDO, inappropriate for the salt intake status, causes cardiac hypertrophy, inflammation, fibrosis and hypertension. The molecular mechanisms that trigger the onset and progression of ALDO-mediated cardiac injury are poorly understood. MicroRNAs (miRNAs) are endogenous, small, non-coding RNAs that have been implicated in diverse cardiac pathologies, yet very little is known about their regulation and role in ALDO-mediated cardiac injury...
March 20, 2017: Endocrinology
https://www.readbyqxmd.com/read/28341712/deficiency-of-cardiomyocyte-specific-microrna-378-contributes-to-the-development-of-cardiac-fibrosis-involving-a-transforming-growth-factor-%C3%AE-tgf%C3%AE-1-dependent-paracrine-mechanism
#3
Raghu S Nagalingam, Nagalingam R Sundaresan, Mariam Noor, Mahesh P Gupta, R John Solaro, Madhu Gupta
No abstract text is available yet for this article.
March 24, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28289072/down-regulation-of-mir-15a-b-accelerates-fibrotic-remodelling-in-the-type%C3%A2-2-diabetic-human-and-mouse-heart
#4
Shruti Rawal, Pujika Emani Munasinghe, Prashanth Thevkar Nagesh, Jason Kar Sheng Lew, Gregory T Jones, Michael J A Williams, Philip Davis, Dick Bunton, Ivor F Galvin, Patrick Manning, Regis R Lamberts, Rajesh Katare
Aim: Myocardial fibrosis is a well-established cause of increased myocardial stiffness and subsequent diastolic dysfunction in the diabetic heart. The molecular regulators that drive the process of fibrotic events in the diabetic heart are still unknown. We determined the role of the microRNA (miR)-15 family in fibrotic remodelling of the diabetic heart.Methods and results: Right atrial appendage (RAA) and left ventricular (LV) biopsy tissues collected from diabetic and non-diabetic (ND) patients undergoing coronary artery bypass graft surgery showed significant down-regulation of miR-15a and -15b...
May 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28251559/microrna-98-inhibits-tgf-%C3%AE-1-induced-differentiation-and-collagen-production-of-cardiac-fibroblasts-by-targeting-tgfbr1
#5
Ranran Cheng, Ruiying Dang, Yan Zhou, Min Ding, Huikun Hua
To investigate the effects of miR-98 on TGF-β1-induced cardiac fibrosis in human cardiac fibroblasts (HCFs), and to establish the mechanism underlying these effects, HCFs were transfected with miR-98 inhibitor or mimic, and then treated with or without TGF-β1. The level of miR-98 was determined by qRT-PCR in TGF-β1-induced HCFs. Cell differentiation and collagen accumulation of HCFs were detected by qRT-PCR and Western blot assays, respectively. The mRNA and protein expressions of TGFBR1 were determined by qRT-PCR and Western blotting...
March 1, 2017: Human Cell
https://www.readbyqxmd.com/read/28149909/therapeutic-potential-of-targeting-micrornas-to-regulate-cardiac-fibrosis-mir-433-a-new-fibrotic-player
#6
Jenny Y Y Ooi, Bianca C Bernardo, Julie R McMullen
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28130757/microrna-29-a-crucial-player-in-fibrotic-disease
#7
REVIEW
Zhenjun Deng, Yongjing He, Xujuan Yang, Hang Shi, Ao Shi, Lechun Lu, Li He
Fibrosis is a common pathological state characterized by the excessive accumulation of extracellular matrix components, but the pathogenesis of the disease is still not clear. Previous studies have shown that microRNA-29 (miR-29) can play pivotal roles in the regulation of a variety of organ fibrosis, including cardiac fibrosis, hepatic fibrosis, lung fibrosis, systemic sclerosis, and keloid. In this review, we outline the structure, expression, and regulation of miR-29 as well as its role in fibrotic diseases...
January 28, 2017: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/28123343/let-7a-is-an-antihypertrophic-regulator-in-the-heart-via-targeting-calmodulin
#8
Xin Zhou, Fei Sun, Shenjian Luo, Wei Zhao, Ti Yang, Guiye Zhang, Ming Gao, Renzhong Lu, You Shu, Wei Mu, Yanan Zhuang, Fengzhi Ding, Chaoqian Xu, Yanjie Lu
Background: MicroRNAs (miRNAs) have been emerged as important regulator in a multiple of cardiovascular disease, including arrhythmia, cardiac hypertrophy and fibrosis, and myocardial infarction. The aim of this study was to investigate whether miRNA let-7a has antihypertrophic effects in angiotensin II (AngII)-induced cardiac hypertrophy. Methods: Neonatal rat ventricular myocytes (NRVMs) were exposed to AngII for 36 h as a cellular model of hypertrophy; subcutaneous injection of AngII for 2 weeks was used to establish a mouse model of cardiac hypertrophy in vivo study...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28112175/luteolin-7-diglucuronide-attenuates-isoproterenol-induced-myocardial-injury-and-fibrosis-in-mice
#9
Bing-Bing Ning, Yong Zhang, Dan-Dan Wu, Jin-Gang Cui, Li Liu, Pei-Wei Wang, Wen-Jian Wang, Wei-Liang Zhu, Yu Chen, Teng Zhang
Myocardial injury and ensuing fibrotic alterations impair normal heart architecture and cause cardiac dysfunction. Oxidative stress has been recognized as a key player in the pathogenesis of cardiac injury and progression of cardiac dysfunction, and promoting fibrosis. In the current study we investigated whether luteolin-7-diglucuronide (L7DG), a naturally occurring antioxidant found in edible plants, could attenuate isoproterenol (ISO)-induced myocardial injury and fibrosis in mice and the underlying mechanisms...
March 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28101763/mir-126-affects-brain-heart-interaction-after-cerebral-ischemic-stroke
#10
Jieli Chen, Chengcheng Cui, Xiaoping Yang, Jiang Xu, Poornima Venkat, Alex Zacharek, Peng Yu, Michael Chopp
Cardiovascular diseases are approximately three times higher in patients with neurological deficits than in patients without neurological deficits. MicroRNA-126 (MiR-126) facilitates vascular remodeling and decreases fibrosis and is emerging as an important factor in the pathogenesis of cardiovascular diseases and cerebral stroke. In this study, we tested the hypothesis that decreased miR-126 after ischemic stroke may play an important role in regulating cardiac function. Wild-type (WT), specific conditional-knockout endothelial cell miR-126 (miR-126(EC-/-)), and miR-126 knockout control (miR-126(fl/fl)) mice were subjected to distal middle cerebral artery occlusion (dMCAo) (n = 10/group)...
January 19, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28055991/role-of-mir-24-furin-and-transforming-growth-factor-%C3%AE-1-signal-pathway-in-fibrosis-after-cardiac-infarction
#11
Zhufeng Chen, Sumei Lu, Miao Xu, Peng Liu, Rui Ren, Wanshan Ma
BACKGROUND Cardiac fibrosis after primary infarction is a type of pathological phenomena as shown by increased collagen in myocardial cells. Transforming growth factor (TGF)-β1 is a critical factor participating in myocardial fibrosis. A previous study has shown the inhibitory role on TGF-β1 by microRNA-24 (miR-24) via targeting Furin. This study thus investigated the role of miR-24 and Furin/TGF-β1 in rat myocardial fibrosis. MATERIAL AND METHODS A total of 40 adult SD rats (both males and females) were prepared for myocardial infarction model by ligating the descending branch of left coronary artery after anesthesia...
January 5, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28025989/microrna-142-3p-inhibits-hypoxia-reoxygenation%C3%A2-induced-apoptosis-and-fibrosis-of-cardiomyocytes-by-targeting-high-mobility-group-box%C3%A2-1
#12
Yi Wang, Min Ouyang, Qiong Wang, Zaijin Jian
Myocardial ischemia/reperfusion (I/R) injury may cause the apoptosis of cardiomyocytes as well as cardiac fibrosis, which is characterized as the transdifferentiation of fibroblasts to myofibroblasts and collagen deposition. MicroRNAs (miRNAs or miRs) have been demonstrated to be involved in myocardial I/R injury. However, the underlying molecular mechanism remains largely unclear. In the present study, mouse cardiomyocyte M6200 cells were treated with hypoxia/reoxygenation (H/R). Our data indicated that H/R treatment led to cell apoptosis, the increased expression of fibrosis‑related proteins, namely collagen I, II, III, and fibronectin, as well as the downregulation of miR-142-3p in M6200 cells...
November 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28017695/mir-29c-is-implicated-in-the-cardioprotective-activity-of-panax-notoginseng-saponins-against-isoproterenol-induced-myocardial-fibrogenesis
#13
Li Liu, Bingbing Ning, Jingang Cui, Teng Zhang, Yu Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Panax notoginseng (Burkill) F.H. Chen (Araliaceae) has a long history of clinical application in China for the treatment of cardiovascular diseases. Panax notoginseng saponins (PNS) have been proven to be the major cardioprotective substances of Panax notoginseng (Burkill) F.H. Chen (Araliaceae). AIM OF THE STUDY: The current study further investigated the molecular mechanisms associated with the cardioprotective effect of PNS. MATERIALS AND METHODS: C57BL/6J mice were subject to isoproterenol (ISO)-induced myocardial injury in the absence or presence of PNS treatment...
December 22, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27997889/mir-22-may-suppress-fibrogenesis-by-targeting-tgf%C3%AE-r-i-in-cardiac-fibroblasts
#14
Yuan Hong, Huaming Cao, Qiang Wang, Jianlin Ye, Lijun Sui, Jinhua Feng, Xiaojun Cai, Huizhu Song, Xiuhong Zhang, Xichuang Chen
BACKGROUND/AIMS: Cardiac fibrosis after myocardial infarction (MI) has been identified as a key factor in the development of heart failure, but the mechanisms undelying cardiac fibrosis remained unknown. microRNAs (miRNAs) are novel mechanisms leading to fibrotic diseases, including cardiac fibrosis. Previous studies revealed that miR-22 might be a potential target. However, the roles and mechanisms of miR-22 in cardiac fibrosis remained ill defined. The present study thus addressed the impact of miR-22 in cardiac fibrosis...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27994552/exercise-training-attenuates-right-ventricular-remodeling-in-rats-with-pulmonary-arterial-stenosis
#15
Brunno Lemes de Melo, Stella S Vieira, Ednei L Antônio, Luís F N Dos Santos, Leslie A Portes, Regiane S Feliciano, Helenita A de Oliveira, José A Silva, Paulo de Tarso C de Carvalho, Paulo J F Tucci, Andrey J Serra
Introduction: Pulmonary arterial stenosis (PAS) is a congenital defect that causes outflow tract obstruction of the right ventricle (RV). Currently, negative issues are reported in the PAS management: not all patients may be eligible to surgeries; there is often the need for another surgery during passage to adulthood; patients with mild stenosis may have later cardiac adverse repercussions. Thus, the search for approaches to counteract the long-term PAS effects showed to be a current target. At the study herein, we evaluated the cardioprotective role of exercise training in rats submitted to PAS for 9 weeks...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27924974/mir-155-regulates-high-glucose-induced-cardiac-fibrosis-via-the-tgf-%C3%AE-signaling-pathway
#16
Dong Zhang, Yongchun Cui, Bin Li, Xiaokang Luo, Bo Li, Yue Tang
Cardiac fibrosis, as a pathological process, plays an important role in various cardiac diseases. microRNA-155 (miR-155) is one of the most important miRNAs, and previous studies have shown that it is a regulatory factor in various fibrotic diseases. However, the mechanism by which miR-155 affects myocardial fibrosis remains unclear. In this study, we aim to establish the biological function of miR-155 in myocardial fibrosis induced by diabetes in mice. We used normal C57BL/6 wild type (WT) and miR-155 knockout (KO) mice to establish the diabetic model by intraperitoneal injection of streptozotocin, and we utilized echocardiography to evaluate the cardiac function at 30 and 60 days post-modeling...
December 20, 2016: Molecular BioSystems
https://www.readbyqxmd.com/read/27922664/expression-of-bcl-2-and-micrornas-in-cardiac-tissues-of-patients-with-dilated-cardiomyopathy
#17
Yong Wang, Min Li, Li Xu, Ju Liu, Dong Wang, Quan Li, Lili Wang, Peijie Li, Shanliang Chen, Tianqi Liu
Dilated cardiomyopathy (DCM) is associated with sudden cardiac death and heart failure, resulting in a significant medical burden. The mechanisms underlying the pathogenesis of DCM remain elusive. In the present study, human cardiac tissues from patients with DCM and healthy donors were collected and their pathology was examined. The expression levels of apoptosis regulator Bcl-2 and fibrosis-associated microRNAs were also evaluated. Extensive myocardial fibrosis and apoptosis in DCM cardiac tissues was observed...
January 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27920122/microrna-33-controls-adaptive-fibrotic-response-in-the-remodeling-heart-by-preserving-lipid-raft-cholesterol
#18
Masataka Nishiga, Takahiro Horie, Yasuhide Kuwabara, Kazuya Nagao, Osamu Baba, Tetsushi Nakao, Tomohiro Nishino, Daihiko Hakuno, Yasuhiro Nakashima, Hitoo Nishi, Fumiko Nakazeki, Yuya Ide, Satoshi Koyama, Masahiro Kimura, Ritsuko Hanada, Tomoyuki Nakamura, Tsukasa Inada, Koji Hasegawa, Simon J Conway, Toru Kita, Takeshi Kimura, Koh Ono
RATIONALE: Heart failure (HF) and atherosclerosis share the underlying mechanisms of chronic inflammation followed by fibrosis. A highly conserved microRNA (miR), miR-33 is considered as a potential therapeutic target for atherosclerosis because it regulates lipid metabolism and inflammation. However, the role of miR-33 in HF remains to be elucidated. OBJECTIVE: To clarify the role of miR-33 involved in HF. METHODS AND RESULTS: We first investigated the expression levels of miR-33a/b in human cardiac tissue samples with dilated cardiomyopathy...
December 5, 2016: Circulation Research
https://www.readbyqxmd.com/read/27917273/involvement-of-microrna-133-and-29-in-cardiac-disturbances-in-diabetic-ovariectomized-rats
#19
Parisa Habibi, Alireza Alihemmati, Mohammadreza Nasirzadeh, Hadi Yousefi, Mohammadrasoul Habibi, Nasser Ahmadiasl
OBJECTIVES: Menopause and diabetes obviously increase the risk of cardiovascular disease in women. The aims of the present study were to evaluate the effects of ovariectomy in type 2 diabetes on the histology and expression of miRNA-29, miRNA-133, IGF-1 and Bcl-2 genes and Bcl-2 protein and caspase 3 activity in the hearts of female rats. MATERIALS AND METHODS: Forty Female Wistar rats were divided into four groups: control, sham, ovariectomized (OVX), and ovariectomized with type 2 diabetes (OVX...
November 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27916680/the-role-of-micrornas-in-heart-failure
#20
REVIEW
Hongjiang Wang, Jun Cai
MicroRNAs are small non-coding RNA molecules that regulate gene expression by inhibiting mRNA translation and/or inducing mRNA degradation. In the past decade, many in vitro and in vivo studies have explored the involvement of microRNAs in various cardiovascular diseases. In this paper, studies focused upon the target genes and functionality of miRNAs in the pathophysiological processes of heart failure are reviewed. The selected miRNAs are categorized according to the biological relevance of their target genes in relation to four cardiovascular pathologies, namely angiogenesis, cardiac hypertrophy, fibrosis and apoptosis...
December 1, 2016: Biochimica et Biophysica Acta
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