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MicroRNA cardiac fibrosis

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https://www.readbyqxmd.com/read/29143975/sustained-cardiac-programming-by-short-term-juvenile-exercise-training-in-male-rats
#1
Y Asif, M E Wlodek, M J Black, A P Russell, P F Soeding, G D Wadley
The aim of this study was to investigate if endurance training during juvenile life 'reprograms' the heart and leads to sustained improvements in the structure, function, and morphology of the adult heart. Male Wistar Kyoto rats were exercise trained 5 days/week for four weeks in either juvenile (5-9 weeks of age), adolescent (11-15 weeks of age) or adult life (20-24 weeks of age). Juvenile exercise training, when compared to 24 week old sedentary rats, led to sustained increases in left ventricle (LV) mass (+18%; P < 0...
November 16, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29141446/myocardial-reparative-functions-of-exosomes-from-mesenchymal-stem-cells-are-enhanced-by-hypoxia-treatment-of-the-cells-via-transferring-microrna-210-in-an-nsmase2-dependent-way
#2
Jinyun Zhu, Kai Lu, Ning Zhang, Yun Zhao, Qunchao Ma, Jian Shen, Yinuo Lin, Pingping Xiang, Yaoliang Tang, Xinyang Hu, Jinghai Chen, Wei Zhu, Keith A Webster, Jian'an Wang, Hong Yu
Hypoxia treatment enhances paracrine effect of mesenchymal stem cells (MSCs). The aim of this study was to investigate whether exosomes from hypoxia-treated MSCs (Exo(H)) are superior to those from normoxia-treated MSCs (Exo(N)) for myocardial repair. Mouse bone marrow-derived MSCs were cultured under hypoxia or normoxia for 24 h, and exosomes from conditioned media were intramyocardially injected into infarcted heart of C57BL/6 mouse. Exo(H) resulted in significantly higher survival, smaller scar size and better cardiac functions recovery...
November 16, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29117535/rescuing-infusion-of-mirna-1-prevents-cardiac-remodeling-in-a-heart-selective-mirna-deficient-mouse
#3
Shuilian Luo, Yuhang Chen, Rui He, Yujun Shi, Li Su
OBJECTIVE: The decreased expression of muscle-specific microRNA-1 (miR-1) has been found in many cardiovascular diseases and is considered to contribute to heart failure (HF). Here we investigated the role of miR-1 in myocardium protection by infusion of miR-1 in a cardiac global miRNA-deficient mouse. METHODS: We generated a cardiac-selective miRNA-deficient mouse by crossing Dicer(flox/flox) mice with mice expressing tamoxifen-inducible Cre recombinase under the control of a mouse αMHC promoter...
November 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29114000/microrna-130a-a-potential-antifibrotic-target-in-cardiac-fibrosis
#4
Li Li, Kelsey R Bounds, Piyali Chatterjee, Sudhiranjan Gupta
BACKGROUND: Cardiac fibrosis occurs because of disruption of the extracellular matrix network leading to myocardial dysfunction. Angiotensin II has been implicated in the development of cardiac fibrosis. Recently, microRNAs have been identified as an attractive target for therapeutic intervention in cardiac pathologies; however, the underlying mechanism of microRNAs in cardiac fibrosis remains unclear. MicroRNA-130a (miR-130a) has been shown to participate in angiogenesis and cardiac arrhythmia; however, its role in cardiac fibrosis is unknown...
November 7, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29101298/loss-of-microrna-22-prevents-high-fat-diet-induced-dyslipidemia-and-increases-energy-expenditure-without-affecting-cardiac-hypertrophy
#5
Gabriela Placoná Diniz, Zhan-Peng Huang, Jianming Liu, Jinghai Chen, Jian Ding, Renata Inzinna Fonseca, Maria Luiza Barreto-Chaves, Jose Donato, Xiaoyun Hu, Da-Zhi Wang
Obesity is associated with development of diverse diseases, including cardiovascular diseases and dyslipidemia. MiRNA-22 (miR-22) is a critical regulator of cardiac function and targets genes involved in metabolic processes. Previously we generated miR-22 null mice and we showed that loss of miR-22 blunted cardiac hypertrophy induced by mechanohormornal stress. In this study, we examined the role of miR-22 in the cardiac and metabolic alterations promoted by high fat (HF) diet. We found that loss of miR-22 attenuated the gain of fat mass and prevented dyslipidemia induced by HF diet, although the body weight gain, or glucose intolerance and insulin resistance did not seem to be affected...
November 3, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29094041/microrna-as-a-therapeutic-target-in-cardiac-remodeling
#6
REVIEW
Chao Chen, Murugavel Ponnusamy, Cuiyun Liu, Jinning Gao, Kun Wang, Peifeng Li
MicroRNAs (miRNAs) are small RNA molecules that contain 18-25 nucleotides. The alterations in their expression level play crucial role in the development of many disorders including heart diseases. Myocardial remodeling is the final pathological consequence of a variety of myocardial diseases. miRNAs have central role in regulating pathogenesis of myocardial remodeling by modulating cardiac hypertrophy, cardiomyocytes injury, cardiac fibrosis, angiogenesis, and inflammatory response through multiple mechanisms...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29063105/the-roles-of-microrna-22-in-myocardial-infarction
#7
Bin-Hai Cong, Xiao-Yan Zhu, Xin Ni
Myocardial infarction (MI) is the leading cause of morbidity and mortality worldwide. The regeneration capacity of the adult mammalian heart is very limited, so that the lost cells are replaced by fibrotic scar. This is followed by remodeling of the surrounding myocardium, which includes cardiac hypertrophy and fibrosis, and makes the ventricular wall thicken and stiffen. This adverse cardiac remodeling leads to impaired cardiac function and eventually leads to heart failure. Extensive studies have revealed that microRNAs (miRNAs) play an essential role in cardiovascular diseases...
October 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/29026447/epigenome-alterations-in-aortic-valve-stenosis-and-its-related-left-ventricular-hypertrophy
#8
REVIEW
Igor Gošev, Martina Zeljko, Željko Đurić, Ivana Nikolić, Milorad Gošev, Sanja Ivčević, Dino Bešić, Zoran Legčević, Frane Paić
Aortic valve stenosis is the most common cardiac valve disease, and with current trends in the population demographics, its prevalence is likely to rise, thus posing a major health and economic burden facing the worldwide societies. Over the past decade, it has become more than clear that our traditional genetic views do not sufficiently explain the well-known link between AS, proatherogenic risk factors, flow-induced mechanical forces, and disease-prone environmental influences. Recent breakthroughs in the field of epigenetics offer us a new perspective on gene regulation, which has broadened our perspective on etiology of aortic stenosis and other aortic valve diseases...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28968594/mirna-expression-profile-of-the-myocardial-tissue-of-pigs-with-coronary-microembolization
#9
Qiang Su, Lang Li, Jinmin Zhao, Yuhan Sun, Huafeng Yang
BACKGROUND/AIMS: Coronary microembolization (CME) is a serious complication of coronary heart disease and is considered as a strong predictor of poor long-term prognosis and major cardiac adverse events. Here, we identified differentially expressed microRNAs (miRNAs) in the myocardial tissue of CME pigs, and predicted and analyzed the possible functions of their target genes. METHODS: Twelve Bama mini-pigs were randomly assigned to the sham and CME group (n = 6 in each group)...
October 2, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28948000/wnt-%C3%AE-catenin-pathway-in-arrhythmogenic-cardiomyopathy
#10
REVIEW
Alessandra Lorenzon, Martina Calore, Giulia Poloni, Leon J De Windt, Paola Braghetta, Alessandra Rampazzo
Wnt/β-catenin signaling pathway plays essential roles in heart development as well as cardiac tissue homoeostasis in adults. Abnormal regulation of this signaling pathway is linked to a variety of cardiac disease conditions, including hypertrophy, fibrosis, arrhythmias, and infarction. Recent studies on genetically modified cellular and animal models document a crucial role of Wnt/β-catenin signaling in the molecular pathogenesis of arrhythmogenic cardiomyopathy (AC), an inherited disease of intercalated discs, typically characterized by ventricular arrhythmias and progressive substitution of the myocardium with fibrofatty tissue...
September 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28944921/inhibition-of-microrna%C3%A2-155-ameliorates-cardiac-fibrosis-in-the-process-of-angiotensin-ii%C3%A2-induced-cardiac-remodeling
#11
Yuzhen Wei, Xiaofei Yan, Lianhua Yan, Fen Hu, Wenhan Ma, Ya Wang, Shuai Lu, Qiutang Zeng, Zhaohui Wang
Cardiac fibrosis triggered by pressure overload represents one of the major challenges in the treatment of cardiovascular diseases. MicroRNA (miRNA/miR)‑155, a member of the small RNA family, has previously been demonstrated to be associated with cardiac inflammation. However, the effect of miR‑155 on cardiac fibrosis induced by angiotensin II (Ang II), particularly in cardiac fibroblasts, requires further investigation. The present study aimed to investigate the effect of miR‑155 in Ang II‑induced cardiac fibrosis using animal models and cardiac fibroblasts...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944900/circulating-mirna%C3%A2-21-is-a-promising-biomarker-for-heart-failure
#12
Jianghua Zhang, Qiang Xing, Xianhui Zhou, Jinxin Li, Yaodong Li, Lin Zhang, Qina Zhou, Baopeng Tang
microRNA 21 (miRNA‑21) promotes the development of cardiac fibrosis, hypertrophy and heart failure. However, whether it can be used as a biomarker for the diagnosis and prognosis of heart failure remains unclear. The current study assessed circulating miRNA‑21 as a viable indicator for diagnosis and prognosis of heart failure. The levels of miRNA‑21 and brain natriuretic peptide were measured in serum obtained from the peripheral vein (miRNA‑21‑PV) and coronary sinus (miRNA‑21‑CS) of 80 patients with heart failure and 40 control individuals via reverse transcription‑quantitative polymerase chain reaction and ELISA, respectively...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28936736/pathological-effects-of-exosomes-in-mediating-diabetic-cardiomyopathy
#13
Esam S B Salem, Guo-Chang Fan
Diabetic subjects are at risk of developing cardiovascular disease, which accounts for 60-80% of diabetes-related mortality. Atherosclerosis is still considered as a leading cause of heart failure in diabetic patients, but it could also be an intrinsic and long-term effect of contractile cardiac cells malfunction, known as diabetic cardiomyopathy (DCM). Pathologically, this cardiac dysfunction is manifested by inflammation, apoptosis, fibrosis, hypertrophy and altered cardiomyocytes metabolism. However, the underlying molecular mechanisms of DCM pathophysiology are not clearly understood...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28934669/transforming-growth-factor-beta-tgf-%C3%AE-mediates-cardiac-fibrosis-and-induces-diabetic-cardiomyopathy
#14
REVIEW
Yiyang Yue, Ke Meng, Yuejie Pu, Xiaoming Zhang
Cardiovascular diseases account for the major cause of morbidity and mortality among individuals with diabetes. The diabetic cardiomyopathy (DCM) is a type of diabetic cardiovascular disease, which further directs to the heart failure. The researchers found that diabetes induced cardiac fibrosis plays a vital role in several of the pathological changes that associated with DCM, causing left ventricular hypertrophy (LVH), diastolic dysfunction and systolic dysfunction. However, the mechanisms involved in the pathogenesis of DCM are still elusive...
September 1, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28901491/mir%C3%A2-21-attenuates-contrast%C3%A2-induced-renal-cell-apoptosis-by-targeting-pdcd4
#15
Kun Wang, Wei-Jie Bei, Yuan-Hui Liu, Hua-Long Li, Shi-Qun Chen, Kai-Yang Lin, Zhi-Ling Zhou, Ji-Yan Chen, Yong Liu, Ning Tan
Contrast medium (CM) is widely used in cardiac catheterization; however, it may induce acute kidney injury or renal failure, although the underlying mechanism remains to be elucidated. MicroRNA‑21 (miR‑21) is involved in renal disease and has been indicated to regulate cellular apoptosis and fibrosis, although its role in CM‑induced renal cell injury is unknown. The present study examined the expression and potential targets of miR‑21 in human renal proximal tubular epithelial (HK‑2) cells following CM treatment...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28865712/microrna-31-promotes-adverse-cardiac-remodeling-and-dysfunction-in-ischemic-heart-disease
#16
Eliana C Martinez, Shera Lilyanna, Peipei Wang, Leah A Vardy, Xiaofei Jiang, Arunmozhiarasi Armugam, Kandiah Jeyaseelan, Arthur Mark Richards
RATIONALE: Myocardial infarction (MI) triggers a dynamic microRNA response with the potential of yielding therapeutic targets. OBJECTIVE: We aimed to identify novel aberrantly expressed cardiac microRNAs post-MI with potential roles in adverse remodeling in a rat model, and to provide post-ischemic therapeutic inhibition of a candidate pathological microRNA in vivo. METHODS AND RESULTS: Following microRNA array profiling in rat hearts 2 and 14days post-MI, we identified a time-dependent up-regulation of miR-31 compared to sham-operated rats...
November 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28777253/mir-30e-attenuates-isoproterenol-induced-cardiac-fibrosis-through-suppressing-snai1-tgf%C3%AE-signaling
#17
Zhang Wenqi, Chang Hong, Zhang Hexun, Zhang Lei
BACKGROUND: MicroRNAs (miRNAs) are a class of small RNA molecules that inhibit protein expression through either degradation of mRNA or interference with protein translation. Our previous work suggested an involvement of miR-30e in myocardial fibrosis; however, the exact role of miR-30e in the pathogenesis of cardiac fibrosis and the underlying mechanisms are not known. METHODS: Male Sprague Dawley rats were treated with isoproterenol to induce cardiac remodeling and fibrosis and treated with either miR-30e agomir (AG) or antagomir and respective controls...
August 4, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28772031/local-microrna-133a-downregulation-is-associated-with-hypertrophy-in-the-dyssynchronous-heart
#18
Lars B van Middendorp, Marion Kuiper, Chantal Munts, Philippe Wouters, Jos G Maessen, Frans A van Nieuwenhoven, Frits W Prinzen
AIMS: Left bundle branch block (LBBB) creates considerable regional differences in mechanical load within the left ventricle (LV). We investigated expression of selected microRNAs (miRs) in relation to regional hypertrophy and fibrosis in LBBB hearts and their reversibility upon cardiac resynchronization therapy (CRT). METHODS AND RESULTS: Eighteen dogs were followed for 4 months after induction of LBBB, 10 of which received CRT after 2 months. Five additional dogs served as control...
August 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28753062/long-noncoding-rna-h19-acts-as-a-competing-endogenous-rna-to-mediate-ctgf-expression-by-sponging-mir-455-in-cardiac-fibrosis
#19
Zhi-Wen Huang, Li-Hong Tian, Bin Yang, Run-Min Guo
Cardiac fibrosis is closely related to multiple cardiovascular system diseases, and noncoding RNAs (ncRNAs), including long noncoding RNA (lncRNA) and microRNA (miRNA), have been reported to play a vital role in fibrogenesis. The present study aims to investigate the potential regulatory mechanism of lncRNA H19 and miR-455 on fibrosis-associated protein synthesis in cardiac fibroblasts (CFs). miRNA microarray assay revealed 34 significantly dysregulated miRNAs, including 13 upregulated miRNAs and 21 downregulated miRNAs...
September 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28740551/modulating-micrornas-as-novel-therapeutic-targets-in-cardiac-fibrosis
#20
COMMENT
Zhongxiu Chen, Yajiao Li, Ke Dian, Li Rao
This commentary highlights the findings by Tao et al. (Theranostics 2016; 6: 2068-2083) that targeting miR-433 may be a potential therapeutic strategy for myocardial fibrosis and subsequently discusses the obstacles and prospects associated with the application of therapeutic microRNAs in anti-fibrosis treatment.
2017: Theranostics
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