Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Chien-Hao Wang, Jai-Sing Yang, Chao-Jung Chen, San-Hua Su, Hsin-Yuan Yu, Yu-Ning Juan, Yu-Jen Chiu, Tsung-Jung Ho
OBJECTIVES: The protective effects and related mechanisms of Jing-Si herbal tea (JSHT) were investigated in cellular damage mediated by pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α, on normal human lung fibroblast by multiomic platform analysis. MATERIALS AND METHODS: The in silico high-throughput target was analyzed using pharmacophore models by BIOVIA Discovery Studio 2022 with ingenuity pathway analysis software...
2024: Tzu chi medical journal
#22
JOURNAL ARTICLE
Gilda Zarate-Gonzalez, Paul Brown, Ricardo Cisneros
INTRODUCTION: The San Joaquin Valley (SJV) is often recognized as one of the most polluted regions in the US. Periods of pollution exposure are associated with increased health burden related to respiratory inflammation and undermined lung function, which aggravates respiratory diseases such as asthma and leads to symptoms such as coughing, wheezing, or difficulty breathing. Asthma costs US$ 82 billion annually in healthcare costs, missed work and school in the US. METHODS: Employing a societal perspective, a cost of illness design was combined with environmental epidemiological methods to analyze the economic impact of O3 , NO2 , and PM2...
2024: Journal of Asthma and Allergy
#23
JOURNAL ARTICLE
Géraldine De Muylder, Valeska Laisnez, Giulietta Stefani, Caroline Boulouffe, Christel Faes, Naïma Hammami, Pierre Hubin, Geert Molenberghs, Jasper Sans, Cecile van de Konijnenburg, Stefaan Van der Borght, Ruben Brondeel, Jorgen Stassijns, Tinne Lernout
The COVID-19 pandemic led to sustained surveillance efforts, which made unprecedented volumes and types of data available. In Belgium, these data were used to conduct a targeted and regular assessment of the epidemiological situation. In addition, management tools were developed, incorporating key indicators and thresholds, to define risk levels and offer guidance to policy makers. Categorizing risk into various levels provided a stable framework to monitor the COVID-19 epidemiological situation and allowed for clear communication to authorities...
2024: Frontiers in Public Health
#24
Marta San Luciano, Carina R Oehrn, Sarah S Wang, John S Tolmie, Allisun Wiltshire, Rebecca E Graff, Jennifer Zhu, Philip A Starr
Background: Movement and tone disorders in children and young adults with cerebral palsy are a great source of disability. Deep brain stimulation (DBS) of basal ganglia targets has a major role in the treatment of isolated dystonias, but its efficacy in dyskinetic cerebral palsy (DCP) is lower, due to structural basal ganglia and thalamic damage and lack of improvement of comorbid choreoathetosis and spasticity. The cerebellum is an attractive target for DBS in DCP since it is frequently spared from hypoxic ischemic damage, it has a significant role in dystonia network models, and small studies have shown promise of dentate stimulation in improving CP-related movement and tone disorders...
April 1, 2024: Research Square
#25
Trisha F Hue, Jeffrey C Lotz, Patricia Zheng, Dennis M Black, Jeannie Bailey, Susan K Ewing, Aaron J Fields, Wolf Mehling, Aaron Scheffler, Irina Strigo, Thomas Petterson, Lucy A Wu, Conor O'Neill
OBJECTIVE: The University of California, San Francisco (UCSF) Core Center for Patient-centric, Mechanistic Phenotyping in Chronic Low Back Pain (REACH) is one of the three NIH Back Pain Consortium (BACPAC) Research Programs Mechanistic Research Centers (MRCs). The goal of UCSF REACH is to define cLBP phenotypes and pain mechanisms that can lead to effective, personalized treatments for patients across the population. The primary objective of this research project is to address the critical need for new diagnostic and prognostic markers, and associated patient classification protocols for chronic low back pain (cLBP) treatment...
April 12, 2024: medRxiv
#26
Wenjun Shen, Cheng Liu, Yunfei Hu, Yuanfang Lei, Hau-San Wong, Si Wu, Xin Maizie Zhou
A main limitation of bulk transcriptomic technologies is that individual measurements normally contain contributions from multiple cell populations, impeding the identification of cellular heterogeneity within diseased tissues. To extract cellular insights from existing large cohorts of bulk transcriptomic data, we present CSsingle, a novel method designed to accurately deconvolve bulk data into a predefined set of cell types using a scRNA-seq reference. Through comprehensive benchmark evaluations and analyses using diverse real data sets, we reveal the systematic bias inherent in existing methods, stemming from differences in cell size or library size...
April 9, 2024: bioRxiv
#27
Natali Sorajja, Joon Chung, Carmela Alcántara, Sylvia Wassertheil-Smoller, Frank J Penedo, Alberto R Ramos, Krista M Perreira, Martha L Daviglus, Shakira F Suglia, Linda C Gallo, Peter Y Liu, Susan Redline, Carmen R Isasi, Tamar Sofer
BACKGROUND: Sex differences are related to both biological factors and the gendered environment. To untangle sex-related effects on health and disease it is important to model sex-related differences better. METHODS: Data came from the baseline visit of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a longitudinal cohort study following 16,415 individuals recruited at baseline from four study sites: Bronx NY, Miami FL, San Diego CA, and Chicago IL...
April 10, 2024: medRxiv
#28
JOURNAL ARTICLE
İsmail Şan, Hanife Gülhan Orhan Karsak, Eyüp İzci, Kübra Öncül
This study delves into the intricate dynamics of internet addiction among university students, leveraging a comprehensive quantitative approach to unravel the myriad factors influencing this modern-day malaise. Utilizing logistic regression analysis, this research delineates the predictive significance of Daily Internet Usage Time (DIUT) and Communicative Internet Use Frequency (CIUF) on the propensity for internet addiction, with the analysis substantiating these variables as potent predictors. The model elucidates a significant variance in internet addiction, affirming the complexity of internet addiction as influenced by a constellation of behavioral patterns...
April 30, 2024: Heliyon
#29
JOURNAL ARTICLE
Alhelí Calderón-Villarreal, Lourdes Johanna Avelar Portillo, Daniela Abramovitz, Shira Goldenberg, Shawn Flanigan, Penelope J E Quintana, Alicia Harvey-Vera, Carlos F Vera, Gudelia Rangel, Steffanie A Strathdee, Georgia L Kayser
BACKGROUND: Water, sanitation, and hygiene (WASH) access is critical to public health and human dignity. People who inject drugs (PWID) experience stigma and structural violence that may limit WASH access. Few studies have assessed WASH access, insecurity, and inequities among PWID. We describe WASH access, social and geographic inequalities, and factors associated with WASH insecurity among PWID in the Tijuana-San Diego metropolitan area. METHODS: In this cross-sectional binational study, we interviewed PWID (age 18+) in 2020-2021 about WASH access and insecurity...
April 22, 2024: International Journal for Equity in Health
#30
REVIEW
Li Zheng, Yue San, Yuejiao Xing, Joe M Regenstein
Rice protein is highly nutritious and easy to digest and absorb. Its hydrolyzed peptides have significant effects on lowering blood pressure and cholesterol. First, a detailed and comprehensive explanation of rice protein extraction methods was given, and it was found that the combination of enzymatic and physical methods could improve the extraction rate of rice protein, but it was only suitable for laboratory studies. Second, the methods for improving the functional properties of rice protein were introduced, including physical modification, chemical modification, and enzymatic modification...
April 19, 2024: International Journal of Biological Macromolecules
#31
REVIEW
Lucrezia Caselli, Laura Conti, Ilaria De Santis, Debora Berti
Lipid-based nanoparticles (LNPs), ranging from nanovesicles to non-lamellar assemblies, have gained significant attention in recent years, as versatile carriers for delivering drugs, vaccines, and nutrients. Small-angle scattering methods, employing X-rays (SAXS) or neutrons (SANS), represent unique tools to unveil structure, dynamics, and interactions of such particles on different length scales, spanning from the nano to the molecular scale. This review explores the state-of-the-art on scattering methods applied to unveil the structure of lipid-based nanoparticles and their interactions with drugs and bioactive molecules, to inform their rational design and formulation for medical applications...
April 12, 2024: Advances in Colloid and Interface Science
#32
JOURNAL ARTICLE
Marta Colaneri, Camilla Genovese, Federico Fassio, Marta Canuti, Andrea Giacomelli, Anna Lisa Ridolfo, Erika Asperges, Giuseppe Albi, Raffaele Bruno, Spinello Antinori, Antonio Muscatello, Bianca Mariani, Ciro Canetta, Francesco Blasi, Alessandra Bandera, Andrea Gori
INTRODUCTION: Recent studies have highlighted the prognostic value of easily accessible inflammatory markers, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) for predicting severe outcomes in patients affected by Coronavirus disease 2019 (COVID-19). Our study validates NLR and PLR cut-off values from a prior cohort at IRCCS Policlinico San Matteo (OSM) of Pavia, Italy, across two new cohorts from different hospitals. This aims to enhance the generalizability of these prognostic indicators...
April 21, 2024: Infectious Diseases and Therapy
#33
JOURNAL ARTICLE
Manon Baudic, Hiroshige Murata, Fernanda M Bosada, Uirá Souto Melo, Takanori Aizawa, Pierre Lindenbaum, Lieve E van der Maarel, Amaury Guedon, Estelle Baron, Enora Fremy, Adrien Foucal, Taisuke Ishikawa, Hiroya Ushinohama, Sean J Jurgens, Seung Hoan Choi, Florence Kyndt, Solena Le Scouarnec, Vincent Wakker, Aurélie Thollet, Annabelle Rajalu, Tadashi Takaki, Seiko Ohno, Wataru Shimizu, Minoru Horie, Takeshi Kimura, Patrick T Ellinor, Florence Petit, Yves Dulac, Paul Bru, Anne Boland, Jean-François Deleuze, Richard Redon, Hervé Le Marec, Thierry Le Tourneau, Jean-Baptiste Gourraud, Yoshinori Yoshida, Naomasa Makita, Claude Vieyres, Takeru Makiyama, Stephan Mundlos, Vincent M Christoffels, Vincent Probst, Jean-Jacques Schott, Julien Barc
While 3D chromatin organization in topologically associating domains (TADs) and loops mediating regulatory element-promoter interactions is crucial for tissue-specific gene regulation, the extent of their involvement in human Mendelian disease is largely unknown. Here, we identify 7 families presenting a new cardiac entity associated with a heterozygous deletion of 2 CTCF binding sites on 4q25, inducing TAD fusion and chromatin conformation remodeling. The CTCF binding sites are located in a gene desert at 1 Mb from the Paired-like homeodomain transcription factor 2 gene (PITX2)...
April 20, 2024: Nature Communications
#34
JOURNAL ARTICLE
Wenfei Wang, Sanli Feng, Zhuang Li, Zhenyu Qiao, Liusheng Yang, Lin Han, Fei Xu, Xiangyu Dong, Minghui Sheng, Dengqun Sun, Yanjun Sun
BACKGROUND: This study investigated the clinical application of the indocyanine green (ICG) fluorescence navigation technique in bile duct identification during laparoscopic common bile duct exploration (LCBDE) for complex hepatolithiasis. METHODS: Eighty patients with complex hepatolithiasis were admitted to our department between January 2022 and June 2023 and randomly divided into control and observation groups. The control group underwent conventional LCBDE, while the observation group underwent LCBDE guided by ICG fluorescence...
April 20, 2024: BMC Surgery
#35
JOURNAL ARTICLE
Ling-Wan Chiu, Yi-En Ku, Horng-Jiun Chao, Wen-Nung Lie, Fan Ying Chan, San-Yuan Wang, Wan-Chen Shen, Hsiang-Yin Chen
OBJECTIVES: Colistin-induced nephrotoxicity prolongs hospitalization and increases mortality. The study aimed to construct machine learning models to predict colistin-induced nephrotoxicity in patients with multidrug-resistant gram-negative infection. METHODS: Patients receiving colistin from three hospitals in the Clinical Research Database were included. Data were divided into a derivation cohort (2011∼2017) and a temporal validation cohort (2018∼2020)...
April 18, 2024: International Journal of Antimicrobial Agents
#36
REVIEW
Tingting Zhang, Xiao-San Luo, Amit Kumar, Xin Liu, Xin Tong, Xuewen Yao, Jiayi Fan, Zhihuai Chen, Sadashiv Chaturvedi
Micro-nano plastics (MNPs; size < 5 mm), ubiquitous and emerging pollutants, accumulated in the natural environment through various sources, and are likely to interact with nutrients, thereby influencing their biogeochemical cycle. Increasing scientific evidences reveal that MNPs can affect nitrogen (N) cycle processes by affecting biotopes and organisms in the environmental matrix and MNPs biofilms, thus plays a crucial role in nitrous oxide (N2 O) and ammonia (NH3 ) emission. Yet, the mechanism and key processes behind this have not been systematically reviewed in natural environments...
April 18, 2024: Chemosphere
#37
JOURNAL ARTICLE
Fatma Sanli, Arzu Tatar, Betul Gundogdu, Omer Faruk Karatas
Head and neck cancer (HNC) is the sixth most common malignancy worldwide. Although current modalities offer a wide variety of therapy choices, head and neck carcinoma has poor prognosis due to its diagnosis at later stages and development of resistance to current therapeutic tools. In the current study, we aimed at exploring the roles of miR-200c-3p during head and neck carcinogenesis and acquisition of taxol resistance. We analyzed miR-200c-3p levels in HNC clinical samples and cell lines using quantitative real-time polymerase chain reaction and evaluated the effects of differential miR-200c-3p expression on cancer-related cellular phenotypes using in-vitro tools...
April 18, 2024: European Journal of Pharmacology
#38
JOURNAL ARTICLE
Taqwa Brookins, Danyion Reagan, Moranda Tate, Bow Suprasert, Kelly D Taylor, Raul Ruiz, Kassandra Miller, Erin C Wilson, Willi McFarland
HIV disproportionately affects Black/African Americans (AA), while PrEP is under-utilized by Black/AA, women, and people who inject drugs (PWID). In San Francisco, California's National HIV Behavioral Surveillance among PWID in 2022, Black/AA women were the least likely to be tested for HIV among all groups by sex and race/ethnicity and the least likely to be aware of PrEP among women. Yet, Black/AA women were no less likely to see a healthcare provider in the last year. Data suggest that providers' failure to discuss and address HIV risk with Black/AA female PWID is a major barrier to accessing effective care and prevention...
April 20, 2024: AIDS and Behavior
#39
JOURNAL ARTICLE
Toshiyuki Takamuku, Tomoya Haraguchi, Ryu Sasaki, Yusuke Hozoji, Koichiro Sadakane, Hiroki Iwase
In aqueous binary solvents with fluorinated alcohols, 2,2,2-trifluoroethanol (TFE) and 1,1,1,3,3,3-hexafluoroisopropanol (HFIP), and aliphatic alcohols, ethanol (EtOH) and 2-propanol (2-PrOH), the denaturation of hen egg white lysozyme (HEWL) with increasing alcohol mole fraction x A has been investigated in a wide view from the molecular vibration to the secondary and ternary structures. Circular dichroism (CD) measurement showed that the secondary structure of α-helix content of HEWL increases on adding a small amount of the fluorinated alcohol to the aqueous solution, while the β-sheet content decreases...
April 20, 2024: Journal of Physical Chemistry. B
#40
JOURNAL ARTICLE
Sharanpreet Kaur, Paula Morales-Hidalgo, Núria Voltas, Josefa Canals-Sans
An early detection of Neurodevelopmental Disorders (NDDs) is crucial for their prognosis; however, the clinical heterogeneity of some disorders, such as autism spectrum disorder (ASD) or attention-deficit hyperactivity disorder (ADHD) is an obstacle to accurate diagnoses in children. In order to facilitate the screening process, the current study aimed to identify symptom-based clusters among a community-based sample of preschool and school-aged children, using behavioral characteristics reported by teachers...
April 19, 2024: Autism Research: Official Journal of the International Society for Autism Research
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
