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https://www.readbyqxmd.com/read/28734844/tlr3-blockade-in-rhinovirus-induced-experimental-asthma-exacerbations-a-randomized-controlled-study
#1
Philip E Silkoff, Susan Flavin, Robert Gordon, Mathew J Loza, Peter J Sterk, Rene Lutter, Zuzana Diamant, Ronald B Turner, Brian J Lipworth, David Proud, Dave Singh, Andreas Eich, Vibeke Backer, James E Gern, Christian Herzmann, Scott A Halperin, Tjeert T Mensinga, Alfred M Del Vecchio, Patrick Branigan, Lani San Mateo, Frédéric Baribaud, Elliot S Barnathan, Sebastian L Johnston
BACKGROUND: Human rhinoviruses (HRV) commonly precipitate asthma exacerbations. TLR3, an innate pattern-recognition receptor, is triggered by HRV driving inflammation that may worsen asthma. OBJECTIVE: To evaluate an inhibitory monoclonal antibody to TLR3, CNTO3157, on experimental HRV-16 inoculation in healthy and asthmatic subjects. METHODS: In this double-blind multicenter randomized parallel-group study in North America and Europe, healthy and mild-moderate stable asthmatic subjects received single or multiple doses of CNTO 3157 or placebo, respectively, and were then inoculated with HRV-16 within 72 hours...
July 19, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28734290/effect-of-interlamellar-interactions-on-shear-induced-multilamellar-vesicle-formation
#2
Y Kawabata, R Bradbury, S Kugizaki, K Weigandt, Y B Melnichenko, K Sadakane, N L Yamada, H Endo, M Nagao, H Seto
Shear-induced multilamellar vesicle (MLV) formation has been studied by coupling the small-angle neutron scattering (SANS) technique with neutron spin echo (NSE) spectroscopy. A 10% mass fraction of the nonionic surfactant pentaethylene glycol dodecyl ether (C12E5) in water was selected as a model system for studying weak inter-lamellar interactions. These interactions are controlled either by adding an anionic surfactant, sodium dodecyl sulfate, or an antagonistic salt, rubidium tetraphenylborate. Increasing the charge density in the bilayer induces an enhanced ordering of the lamellar structure...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28734107/extended-release-naltrexone-for-methamphetamine-dependence-among-men-who-have-sex-with-men-a-randomized-placebo-controlled-trial
#3
Phillip O Coffin, Glenn-Milo Santos, Jaclyn Hern, Eric Vittinghoff, Deirdre Santos, Tim Matheson, Grant Colfax, Steven L Batki
BACKGROUND AND AIMS: Methamphetamine use is increasingly prevalent and associated with HIV transmission. Early phase human studies suggested naltrexone reduced amphetamine use among dependent individuals. We tested if extended-release naltrexone (XRNTX) reduces methamphetamine use and associated sexual risk behaviors among high-risk methamphetamine-dependent men who have sex with men (MSM). DESIGN: Double-blind, placebo-controlled, randomized trial of XRTNX versus placebo over 12 weeks from 2012-2015...
July 22, 2017: Addiction
https://www.readbyqxmd.com/read/28733711/a-brief-history-of-neurological-botulinum-toxin-therapy-in-germany
#4
REVIEW
Dirk Dressler, Peter Roggenkaemper
Botulinum toxin (BT) has long been infamous in food safety and biological warfare. In the early 1970s, Alan B Scott of San Francisco invented its therapeutic use originally in extraocular eye muscles to treat strabismus using a therapeutic BT type A preparation provided by Edward J Schantz and Eric A Johnson. Subsequently a large number of medical indications based on motor and glandular hyperactivity and-most recently-chronic migraine are now treated by BT therapy. BT's highly specific and elaborate mechanism of action represents a completely novel therapeutic principle which will have consequences far beyond existing indications...
July 21, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28733691/pancreatic-panniculitis-sans-pancreatitis-in-a-patient-with-diabetic-ketoacidosis
#5
Wei Liang Koh, Yong Kwang Tay, Victor Wl Ng
No abstract text is available yet for this article.
June 2017: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/28733548/the-survival-benefits-of-local-surgery-in-stage-iv-breast-cancer-are-not-affected-by-breast-cancer-subtypes-a-population-based-analysis
#6
San-Gang Wu, Wen-Weng Zhang, Jia-Yuan Sun, Feng-Yan Li, Huan-Xin Lin, Juan Zhou, Zhen-Yu He
This retrospective study aimed to investigate the clinical value of local surgery in stage IV BC and determined whether the survival outcomes were affected by the breast cancer subtype (BCS). Women with de novo stage IV BC from 2010 to 2013 were included using the Surveillance Epidemiology and End Results database. Univariate and multivariate Cox regression analyses were performed to evaluate the prognostic factors for breast cancer-specific survival (BCSS) and overall survival (OS). Among 9,256 patients were identified, 3,130 (33...
June 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28733527/effects-of-chinese-herbal-medicines-on-the-occurrence-of-diabetic-retinopathy-in-type-2-diabetes-patients-and-protection-of-arpe-19-retina-cells-by-inhibiting-oxidative-stress
#7
Fuu-Jen Tsai, Te-Mao Li, Cheng-Hang Ko, Chi-Fung Cheng, Tsung-Jung Ho, Xiang Liu, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Ju-Pi Li, Shao-Mei Huang, Jung-Chun Lin, Chih-Chien Lin, Wen-Miin Liang, Ying-Ju Lin
Diabetic retinopathy is a microvascular complication of type 2 diabetes and the leading cause of acquired blindness. In Taiwan, Chinese herbal medicine (CHM) is a popular adjunctive therapy. In this study, we investigated the CHM prescription patterns and their effects. We identified 23,701 subjects with type 2 diabetes in a database, and after matching for age and gender, 6,948 patients each were assigned to CHM and non-CHM groups. In the female subgroups, the cumulative retinopathy probability was lower for the CHM users than that for the CHM non-users (P < 0...
June 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28733025/revisiting-historical-khoe-san-skeletal-remains-in-european-collections-a-search-for-identity-through-craniometric-analysis
#8
D Botha, M Steyn, Y Scholtz, I Ribot
As the identity of a large number of Khoe-San skeletal material in European collections recently came into question during its documentation, a re-evaluation of the remains by employing a non-invasive method such as craniometrics was done to investigate the biological affinity. For this purpose, gene flow and population diversity present within the group, as well as between the study sample (N=63) and other modern and historic population groups from southern, central and east Africa were explored. Available comparative groups included the historic Khoe-San from Riet River (N=31), the Sotho-Tswana from southern Africa (N=61), the Basuku from central Africa (N=66) and the Bahutu (N=53) and Teita (N=24) from east Africa...
June 28, 2017: Homo: Internationale Zeitschrift Für die Vergleichende Forschung Am Menschen
https://www.readbyqxmd.com/read/28732238/community-action-for-health-in-india-s-national-rural-health-mission-one-policy-many-paths
#9
Rakhal Gaitonde, Miguel San Sebastian, V R Muraleedharan, Anna-Karin Hurtig
Community participation as a strategy for health system strengthening and accountability is an almost ubiquitous policy prescription. In 2005, with the election of a new Government in India, the National Rural Health Mission was launched. This was aimed at 'architectural correction' of the health care system, and enshrined 'communitization' as one of its pillars. The mission also provided unique policy spaces and opportunity structures that enabled civil society groups to attempt to bring on to the policy agenda as well as implement a more collective action and social justice based approach to community based accountability...
July 1, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28731823/maternal-fetal-outcomes-in-34-pregnant-women-with-type-1-diabetes-in-sensor-augmented-insulin-pump-therapy
#10
Ana María Gómez, Lisseth Fernanda Marín Carrillo, Carol M Arévalo Correa, Oscar Mauricio Muñoz Velandia, Martín Alonso Rondón Sepúlveda, Jaime Luis Silva Herrera, Diana Cristina Henao Carrillo
BACKGROUND: Pregnancy in women with type 1 diabetes (T1D) is associated with increased risk of maternal complications and neonatal morbidity and mortality. Optimizing glycemic control improves these outcomes. OBJECTIVE: To describe the experience of using sensor-augmented insulin pump therapy (SAPT) and SAPT + low-glucose suspension (LGS) on pregnant women with T1D, including neonatal and maternal outcomes. METHODS: A prospective observational study was conducted in women with T1D who started SAPT and SAPT + LGS before or during pregnancy at the San Ignacio University Hospital Diabetes Center in Bogotá, Colombia...
July 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28731348/proton-transport-in-hierarchical-structured-nafion-membranes-a-nmr-study
#11
Hengrui Yang, Jin Zhang, Jingliang Li, San Ping Jiang, Maria Forsyth, Haijin Zhu
It is known that hierarchical structure plays a key role in many unique material properties such as self-cleaning effect of lotus leaves and the anti-fogging property of the compound eyes of mosquitoes. This study reports a series of highly ordered meso-porous Nafion membranes with unique hierarchical structural features at the nanometre scale. Using NMR, we show for the first time that at low RH conditions, the proton in the ionic domains migrates via a surface diffusion mechanism and exhibits approximately two orders of magnitude faster transport than that in the nano-pores, whereas the nano-pores play a role of reservoir and maintain water and thereby conductivity at higher temperature and lower humidities...
July 21, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28731320/fabrication-of-nanostructured-omniphobic-and-superomniphobic-surfaces-with-inexpensive-co2-laser-engraver
#12
Anudeep Pendurthi, Sanli Movafaghi, Wei Wang, Soran Shadman, Azer Yalin, Arun K Kota
Superomniphobic surfaces (i.e. surfaces that are extremely repellent to both high surface tension liquids like water and low surface tension liquid like oils and alcohols) can be fabricated through a combination of surface chemistry that imparts low solid surface energy with a re-entrant surface texture. Recently, surface texturing with lasers has received significant attention because laser texturing is scalable, solvent-free, and can produce a monolithic texture on virtually any material. In this work, we fabricated nanostructured omniphobic and superomniphobic surfaces with a variety of materials using a simple, inexpensive and commercially available CO2 laser engraver...
July 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28730710/the-molecular-ecology-of-microcystis-sp-blooms-in-the-san-francisco-estuary-delta
#13
Timothy G Otten, Hans W Paerl, Theo W Dreher, Wim J Kimmerer, Alex E Parker
Harmful blooms of the cyanobacterium Microcystis sp. have become increasingly pervasive in the San Francisco Estuary Delta (USA) since the early 2000's and their rise has coincided with substantial decreases in several important fish species. We sought to investigate direct and indirect effects Microcystis blooms may have on the Delta food web. The Microcystis population was tracked for two years at six sites throughout the Delta using quantitative PCR. High-throughput amplicon sequencing and colony PCR sequencing revealed the presence of 10 different strains of Microcystis, including six different microcystin-producing strains...
July 20, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28729482/brca1-and-brca2-tumor-suppressors-protect-against-endogenous-acetaldehyde-toxicity
#14
Eliana Mc Tacconi, Xianning Lai, Cecilia Folio, Manuela Porru, Gijs Zonderland, Sophie Badie, Johanna Michl, Irene Sechi, Mélanie Rogier, Verónica Matía García, Ankita Sati Batra, Oscar M Rueda, Peter Bouwman, Jos Jonkers, Anderson Ryan, Bernardo Reina-San-Martin, Joannie Hui, Nelson Tang, Alejandra Bruna, Annamaria Biroccio, Madalena Tarsounas
Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. Endogenous acetaldehyde, a product of cellular metabolism, is a potent source of DNA damage, particularly toxic to cells and mice lacking the FA protein FANCD2. Here, we investigate whether HR-compromised cells are sensitive to acetaldehyde, similarly to FANCD2-deficient cells. We demonstrate that inactivation of HR factors BRCA1, BRCA2, or RAD51 hypersensitizes cells to acetaldehyde treatment, in spite of the FA pathway being functional...
July 20, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28729408/femoral-artery-atherosclerosis-is-associated-with-physical-function-across-the-spectrum-of-the-ankle-brachial-index-the-san-diego-population-study
#15
Christina L Wassel, Alicia M Ellis, Natalie C Suder, Emma Barinas-Mitchell, Dena E Rifkin, Nketi I Forbang, Julie O Denenberg, Antoinette M Marasco, Belinda J McQuaide, Nancy S Jenny, Matthew A Allison, Joachim H Ix, Michael H Criqui
BACKGROUND: The ankle-brachial index (ABI) is inadequate to detect early-stage atherosclerotic disease, when interventions to prevent functional decline may be the most effective. We determined associations of femoral artery atherosclerosis with physical functioning, across the spectrum of the ABI, and within the normal ABI range. METHODS AND RESULTS: In 2007-2011, 1103 multiethnic men and women participated in the San Diego Population Study, and completed all components of the summary performance score...
July 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28728847/a-novel-role-for-bone-derived-cells-in-ankylosing-spondylitis-focus-on-il-23
#16
Sungsin Jo, Bon San Koo, Bitnara Lee, Eunji Kwon, Young Lim Lee, Heekyoung Chung, Il-Hoon Sung, Ye-Soo Park, Tae-Hwan Kim
The main aim of this study are to explore the role of bone-derived cells (BdCs) in ankylosing spondylitis (AS) and determine the underlying molecular mechanisms of IL-23 production. Primary BdCs were isolated from diced bone of facet joints obtained during surgery from seven AS patients and seven disease control (Ct) patients. Osteoblastic activity of BdCs was assessed by measuring their alkaline phosphatase activity and by alizarin red staining. Osteoblast and endoplasmic reticulum (ER) stress-related genes were assessed by quantitative PCR, immunoblotting, immunofluorescence, and immunohistochemistry...
July 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28728633/drinking-status-between-ages-50-and-55-for-men-from-the-san-diego-prospective-study-who-developed-dsm-iv-alcohol-abuse-or-dependence-in-prior-follow-ups
#17
Priscila Dib Gonçalves, Marc A Schuckit, Tom L Smith
OBJECTIVE: Although alcohol use disorders (AUDs) are prevalent among older individuals, few studies have examined the course and predictors of AUDs from their onset into the person's 50s. This study describes the AUD course from ages 50 to 55 in participants who developed AUDs according to criteria from the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), during the San Diego Prospective Study (SDPS). METHOD: Among the 397 university students in the SDPS who were followed about every 5 years from age 20 (before AUD onset), 165 developed AUDs, 156 of whom were interviewed at age 55...
July 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28728525/gender-differences-in-causes-of-death-among-persons-with-hiv-aids-in-san-francisco-california-1996-2013
#18
Nancy A Hessol, Sandra K Schwarcz, Ling Chin Hsu, Martha Shumway, Edward L Machtinger
The objective was to examine gender differences in causes of death using the San Francisco HIV/AIDS and death registries. Data from San Francisco residents diagnosed with HIV/AIDS who died from 1996 to 2013 were analyzed. Age, race/ethnicity, year, and gender-adjusted standardized mortality ratios and Poisson 95% confidence intervals were calculated for underlying causes of death. Among the 6268 deaths, deaths attributed to drug use, mental disorders due to substance use, cerebrovascular disease, chronic obstructive pulmonary disease, renal disease, and septicemia were more likely among women than among men...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28728153/genetic-variants-of-cytochrome-cyp2d6-in-two-mixed-chilean-populations
#19
Mónica Acuña, Eric Pinto, Paulina Olivares, Carolina Ríos
OBJECTIVES: It is known that the interindividual and interethnic variability of the genetic polymorphisms of CYP2D6 plays an important role in the presentation of adverse drug reactions and concerning lack of therapeutic effects in humans. However, there are few data available from mixed populations of Latin America, including the Chilean. The aim of this study was therefore to estimate the frequencies of CYP2D6 variants in two samples of hospitals from the northern (Hospital San José, HSJ) and eastern (Clínica Las Condes, CLC) parts of Santiago, Chile, with different degrees of Amerindian admixture (HSJ: 34...
July 21, 2017: Human Heredity
https://www.readbyqxmd.com/read/28727859/space-flight-associated-neuro-ocular-syndrome
#20
Andrew G Lee, Thomas H Mader, C Robert Gibson, William Tarver
New and unique physiologic and pathologic systemic and neuro-ocular responses have been documented in astronauts during and after long-duration space flight. Although the precise cause remains unknown, space flight-associated neuro-ocular syndrome (SANS) has been adopted as an appropriate descriptive term. The Space Medicine Operations Division of the US National Aeronautics and Space Administration (NASA) has documented the variable occurrence of SANS in astronauts returning from long-duration space flight on the International Space Station...
July 20, 2017: JAMA Ophthalmology
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