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https://www.readbyqxmd.com/read/28329664/prospective-evaluation-of-complications-in-dermatologic-surgery-associated-with-hypertension-conroy
#1
Conroy Chow, Matthew J Simpson, Niko Pascua, Harjot Maan, Jacqueline G Berlier, Siegrid Yu, Isaac Neuhaus, Roy Grekin, Sarah T Arron
BackgroundPoorly controlled hypertension is a known risk factor for surgical complications. OBJECTIVE: This study examines the incidence of complications in participants undergoing Mohsmicrographic surgery (MMS) based on preoperative blood pressure (BP) measurement and investigates the role of potential confounders in the relationship between preoperative BP and postoperative complications.MethodsThis 10-month prospective cohort study at the University of California, San Francisco (UCSF) Dermatologic Surgery Center approached all patients undergoing MMS for participation and assessed for the diagnosis of hypertension, anti-hypertensive medication use, use of tobacco or blood thinners, immunosuppression, concomitant diabetes, or previous treatment with radiation therapy at the surgical site...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329339/interrelations-between-mitochondrial-dna-copy-number-and-inflammation-in-older-adults
#2
I-Chien Wu, Cheng-Chieh Lin, Chin-San Liu, Chih-Cheng Hsu, Ching-Yu Chen, Chao A Hsiung
Background: Interplays between inflammation and mitochondrial biology are reported. Here, we examined the cross-sectional interrelationships of mitochondrial DNA copy number (mtDNACN) and inflammation and their interaction with physical functioning. Methods: A total of 1990 community-dwelling adults aged 65 years and older who were participating in the Healthy Aging Longitudinal Study in Taiwan underwent measurements of peripheral-blood leukocytes MtDNACN, multiple inflammatory markers, grip strength, and gait speed...
March 11, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28328346/efficacy-of-a-low-cost-heat-stable-oral-rotavirus-vaccine-in-niger
#3
Sheila Isanaka, Ousmane Guindo, Celine Langendorf, Amadou Matar Seck, Brian D Plikaytis, Nathan Sayinzoga-Makombe, Monica M McNeal, Nicole Meyer, Eric Adehossi, Ali Djibo, Bruno Jochum, Rebecca F Grais
Background Each year, rotavirus gastroenteritis is responsible for about 37% of deaths from diarrhea among children younger than 5 years of age worldwide, with a disproportionate effect in sub-Saharan Africa. Methods We conducted a randomized, placebo-controlled trial in Niger to evaluate the efficacy of a live, oral bovine rotavirus pentavalent vaccine (BRV-PV, Serum Institute of India) to prevent severe rotavirus gastroenteritis. Healthy infants received three doses of the vaccine or placebo at 6, 10, and 14 weeks of age...
March 23, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28328165/variation-in-growth-rate-carbon-assimilation-and-photosynthetic-efficiency-in-response-to-nitrogen-source-and-concentration-in-phytoplankton-isolated-from-upper-san-francisco-bay
#4
Gry Mine Berg, Sara Driscoll, Kendra Hayashi, Melissa Ross, Raphael Kudela
Six species of phytoplankton recently isolated from upper San Francisco Bay were tested for their sensitivity to growth inhibition by ammonium (NH4(+) ), and for differences in growth rates according to inorganic nitrogen (N) growth source. The quantum yield of photosystem II (Fv /Fm ) was a sensitive indicator of NH4(+) toxicity, manifested by a suppression of Fv /Fm in a dose-dependent manner. Two chlorophytes were the least sensitive to NH4(+) inhibition, at concentrations of >3000 μmoles NH4(+) · L(-1) , followed by two estuarine diatoms which were sensitive at concentrations >1000 μmoles NH4(+) · L(-1) , followed lastly by two freshwater diatoms that were sensitive at concentrations between 200-500 μmoles NH4(+) · L(-1) ...
March 22, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28328134/somatic-pik3ca-mutations-in-seven-patients-with-pik3ca-related-overgrowth-spectrum
#5
Kit San Yeung, Janice Jing Kun Ip, Chin Pang Chow, Evelyn Yue Ling Kuong, Paul Kwong-Hang Tam, Godfrey Chi-Fung Chan, Brian Hon-Yin Chung
Somatic mutations in PIK3CA cause many overgrowth syndromes that have been recently coined the "PIK3CA-Related Overgrowth Spectrum." Here, we present seven molecularly confirmed patients with PIK3CA-Related Overgrowth Spectrum, including patients with Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevi, Scoliosis/Skeletal and Spinal syndrome, Klippel-Trenaunay syndrome, lymphatic malformation and two with atypical phenotypes that cannot be classified into existing disease categories. The literature on PIK3CA-Related Overgrowth Spectrum, suggests that PIK3CA c...
April 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28327610/molecular-level-detection-and-localization-of-mechanical-damage-in-collagen-enabled-by-collagen-hybridizing-peptides
#6
Jared L Zitnay, Yang Li, Zhao Qin, Boi Hoa San, Baptiste Depalle, Shawn P Reese, Markus J Buehler, S Michael Yu, Jeffrey A Weiss
Mechanical injury to connective tissue causes changes in collagen structure and material behaviour, but the role and mechanisms of molecular damage have not been established. In the case of mechanical subfailure damage, no apparent macroscale damage can be detected, yet this damage initiates and potentiates in pathological processes. Here, we utilize collagen hybridizing peptide (CHP), which binds unfolded collagen by triple helix formation, to detect molecular level subfailure damage to collagen in mechanically stretched rat tail tendon fascicle...
March 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28326009/improving-eeg-based-driver-fatigue-classification-using-sparse-deep-belief-networks
#7
Rifai Chai, Sai Ho Ling, Phyo Phyo San, Ganesh R Naik, Tuan N Nguyen, Yvonne Tran, Ashley Craig, Hung T Nguyen
This paper presents an improvement of classification performance for electroencephalography (EEG)-based driver fatigue classification between fatigue and alert states with the data collected from 43 participants. The system employs autoregressive (AR) modeling as the features extraction algorithm, and sparse-deep belief networks (sparse-DBN) as the classification algorithm. Compared to other classifiers, sparse-DBN is a semi supervised learning method which combines unsupervised learning for modeling features in the pre-training layer and supervised learning for classification in the following layer...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28325601/design-and-synthesis-of-novel-6-aryl-substituted-4-anilinequinazoline-derivatives-as-potential-pi3k%C3%AE-inhibitors
#8
Minhang Xin, Yuan-Yuan Hei, Hao Zhang, Ying Shen, San-Qi Zhang
In this study, a series of new 6-aryl substituted 4-anilinequinazolines was designed and synthesized as PI3Kδ inhibitors based on our reported chemical structures. The preliminary structure-activity relationship (SAR) was established, and compounds 13h and 13k displayed most potent PI3Kδ inhibitory activities with the IC50 values of 9.3nM and 9.7nM, respectively. Compound 13h demonstrated similar anti-proliferative profiles to idelalisib against three human B cell lines. Three key hydrogen bonding interactions were found in the docking of 13h with PI3Kδ enzyme...
March 11, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28325529/transcutaneous-stimulation-of-the-posterior-tibial-nerve-for-treating-refractory-urge-incontinence-of-idiopathic-and-neurogenic-origin
#9
C Valles-Antuña, M L Pérez-Haro, C González-Ruiz de L, A Quintás-Blanco, E M Tamargo-Diaz, J García-Rodríguez, A San Martín-Blanco, J M Fernandez-Gomez
OBJECTIVE: To assess the efficacy of treatment with transcutaneous posterior tibial nerve stimulation (TPTNS) in patients with urge urinary incontinence, of neurogenic or nonneurogenic origin, refractory to first-line therapeutic options. MATERIAL AND METHODS: We included 65 patients with urge urinary incontinence refractory to medical treatment. A case history review, a urodynamic study and a somatosensory evoked potentials (SEP) study were conducted before the TPTNS, studying the functional urological condition by means of a voiding diary...
March 18, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28325171/pregnancy-and-neonatal-outcomes-among-a-cohort-of-hiv-infected-women-in-a-large-italian-teaching-hospital-a-30-year-retrospective-study
#10
S Grignolo, R Agnello, D Gerbaldo, C Gotta, C Alicino, F Del Puente, L Taramasso, B Bruzzone, C Gustavino, S Trasino, A DE Maria, G Icardi, C Viscoli, A DI Biagio
The primary study objective was to investigate three decades from 1985 to 2014 of changes in pregnancies among HIV-infected women. The secondary objective was to assess risk factors associated with preterm delivery and severe small-for-gestational-age (SGA) infants in HIV-infected women. A retrospective review of deliveries among pregnant HIV-infected women at the University of Genoa and IRCCS San Martino-IST in Genoa between 1985 and 2014 was performed. Univariate and multivariable analyses were used to study the variables associated with neonatal outcomes...
March 22, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28325009/a-clinic-compatible-open-source-electrophysiology-system
#11
John Hermiz, Nick Rogers, Erik Kaestner, Mehran Ganji, Dan Cleary, Joseph Snider, David Barba, Shadi Dayeh, Eric Halgren, Vikash Gilja
Open source electrophysiology (ephys) recording systems have several advantages over commercial systems such as customization and affordability enabling more researchers to conduct ephys experiments. Notable open source ephys systems include Open-Ephys, NeuroRighter and more recently Willow, all of which have high channel count (64+), scalability, and advanced software to develop on top of. However, little work has been done to build an open source ephys system that is clinic compatible, particularly in the operating room where acute human electrocorticography (ECoG) research is performed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324102/duodenal-mucosa-of-patients-with-type-1-diabetes-shows-distinctive-inflammatory-profile-and-microbiota
#12
Silvia Pellegrini, Valeria Sordi, Andrea Mario Bolla, Diego Saita, Roberto Ferrarese, Filippo Canducci, Massimo Clementi, Francesca Invernizzi, Alberto Mariani, Riccardo Bonfanti, Graziano Barera, Pier Alberto Testoni, Claudio Doglioni, Emanuele Bosi, Lorenzo Piemonti
Context: Increasing evidences suggest a correlation between gut and type 1 diabetes (T1D). Objective: The objective of this study is to evaluate the gut inflammatory profile and microbiota in patients with T1D, compared to healthy controls (CTRL) and patients with celiac disease (CD) as gut inflammatory disease controls. Design/Setting/Participants: The inflammatory status and microbiome composition were evaluated in biopsies of the duodenal mucosa of patients with T1D (n=19), CD (n=19) and CTRL (n=16), recruited at San Raffaele Scientific Institute, in Milan, Italy, between 2009 and 2015...
January 19, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323583/pilots-attention-distributions-between-chasing-a-moving-target-and-a-stationary-target
#13
Wen-Chin Li, Chung-San Yu, Graham Braithwaite, Matthew Greaves
INTRODUCTION: Attention plays a central role in cognitive processing; ineffective attention may induce accidents in flight operations. The objective of the current research was to examine military pilots' attention distributions between chasing a moving target and a stationary target. METHOD: In the current research, 37 mission-ready F-16 pilots participated. Subjects' eye movements were collected by a portable head-mounted eye-tracker during tactical training in a flight simulator...
December 1, 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28323194/international-experts-practice-in-the-antibiotic-therapy-of-infective-endocarditis-is-not-following-the-guidelines
#14
H Tissot-Dupont, J P Casalta, F Gouriet, S Hubert, E Salaun, G Habib, M P Fernandez-Gerlinger, J L Mainardi, P Tattevin, M Revest, F Lucht, E Botelho-Nevers, A Gagneux-Brunon, U Snygg-Martin, K L Chan, J Bishara, I Vilacosta, C Olmos, J A San Román, J López, P Tornos, N Fernández-Hidalgo, E Durante-Mangoni, R Utili, M Paul, L M Baddour, D C De Simone, M R Sohail, J M Steckelberg, W R Wilson, D Raoult
OBJECTIVE: The management of infective endocarditis (IE) may differ from international guidelines, even in reference centers. This is probably due to the fact that most recommendations are not based on hard evidence, so that the consensus obtained for the guidelines does not represent actual practices. For this reason, we aimed at evaluating this question in the particular field of antibiotic therapy. METHODS: Thirteen international centers specialized in the management of IE were selected, according to their reputation, clinical results, original research publications and quotations...
March 18, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28323114/physician-activity-during-outpatient-visits-and-subjective-workload
#15
Alan Calvitti, Harry Hochheiser, Shazia Ashfaq, Kristin Bell, Yunan Chen, Robert El Kareh, Mark T Gabuzda, Lin Liu, Sara Mortensen, Braj Pandey, Steven Rick, Richard L Street, Nadir Weibel, Charlene Weir, Zia Agha
We describe methods for capturing and analyzing EHR use and clinical workflow of physicians during outpatient encounters and relating activity to physicians' self-reported workload. We collected temporally-resolved activity data including audio, video, EHR activity, and eye-gaze along with post-visit assessments of workload. These data are then analyzed through a combination of manual content analysis and computational techniques to temporally align streams, providing a range of process measures of EHR usage, clinical workflow, and physician-patient communication...
March 17, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28322563/molecular-aggregation-in-binary-mixtures-of-pyrrolidine-n-methylpyrrolidine-piperidine-and-n-methylpiperidine-with-water-thermodynamic-sans-and-theoretical-studies
#16
Wojciech Marczak, Mikhail A Varfolomeev, Ilnaz T Rakipov, Piotr Lodowski, Katarzyna Kowalska-Szojda, Marta Łężniak, Laszlo Almasy, Adél Len
Piperidine and N-methylpiperidine hydrates aggregate in liquid aqueous solutions due to hydrogen bonds between hydration water molecules. No such effects occur in the mixtures of the amines with methanol, that supports the idea of active role of water solvent in the aggregation. However, the question of contributions in thermodynamic functions due to specific interactions, van der Waals forces, and the size and shape of the molecules remains open. In the present study, limiting partial molar enthalpies of solution of pyrrolidine, N-methylpyrrolidine, piperidine and N-methylpiperidine in water and methanol and vice versa were measured and compared with those assessed from theoretically calculated molecular interaction energies using a simple "chemical reaction" model...
March 21, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28322305/tuning-of-exchange-coupling-and-switchable-magnetization-dynamics-by-displacing-the-bridging-ligands-observed-in-two-dimeric-manganese-iii-compounds
#17
Xiang-Yu Liu, Pei-Pei Cen, Li-Zhou Wu, Fei-Fei Li, Wei-Ming Song, Gang Xie, San-Ping Chen
Two Mn(III)-based dimers, [Mn2(bpad)2(CH3O)4]n (1) and [Mn2(bpad)2(pa)2]n·2H2O (2) (Hbpad = N(3)-benzoylpyridine-2-carboxamidrazone, H2pa = phthalic acid), have been assembled from a tridentate Schiff-base chelator and various anionic coligands. Noteworthily, compound 1 could be identified as a reaction precursor to transform to 2 in the presence of phthalic acid, resulting in a rarely structural conversion process in which the bridges between intradimer Mn(III) ions alter from methanol oxygen atom with μ2-O mode in 1 (Mn Mn distance of 3...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28321990/diabetes-news
#18
Abigail E Dove, Brian J Levine, Payal H Marathe, Helen X Gao, Kelly L Close
Approximately 100 experts in diabetes gathered for the JDRF Mission Summit in San Francisco, CA, USA from January 26-27, 2017. The meeting focused on upcoming advances in type 1 diabetes therapy, and attendees discussed ways to encourage greater investment in type 1 diabetes research to produce next-generation options for treatment.
March 21, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28320759/basic-occupational-health-services-bohs-in-community-primary-care-the-msf-dhaka-model
#19
Venkiteswaran Muralidhar, Md Faizul Ahasan, Ahad Mahmud Khan, Mohammad Shariful Alam
The Médecins Sans Frontiérs (MSF) established basic occupational health services to diagnose and treat work-related diseases among tannery, metal, plastics and garment workers and families in one of the more polluted areas of the world populated by 600 000 people. In spite of project limitations, an analysis of the 6-month data showed that of the original cohort of 5000, 3200 (64%) came for at least 1 consultation. Among them, 468 (14.6%) were diagnosed with suspected work-related diseases as per defined protocols...
March 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28320562/microstructural-characterization-of-dental-zinc-phosphate-cements-using-combined-small-angle-neutron-scattering-and-microfocus-x-ray-computed-tomography
#20
Alberto Viani, Konstantinos Sotiriadis, Ivana Kumpová, Lucia Mancini, Marie-Sousai Appavou
OBJECTIVE: To characterize the microstructure of two zinc phosphate cement formulations in order to investigate the role of liquid/solid ratio and composition of powder component, on the developed porosity and, consequently, on compressive strength. METHODS: X-ray powder diffraction with the Rietveld method was used to study the phase composition of zinc oxide powder and cements. Powder component and cement microstructure were investigated with scanning electron microscopy...
February 17, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
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