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https://www.readbyqxmd.com/read/28927117/salvia-miltiorrhiza-extract-inhibits-tpa-induced-mmp-9-expression-and-invasion-through-the-mapk-ap-1-signaling-pathway-in-human-breast-cancer-mcf-7-cells
#1
Jeong-Mi Kim, Eun-Mi Noh, Hyun-Kyung Song, Minok Lee, Soo Ho Lee, Sueng Hyuk Park, Chan-Keun Ahn, Guem-San Lee, Eui-Baek Byun, Beom-Su Jang, Kang-Beom Kwon, Young-Rae Lee
Cancer cell invasion is crucial for metastasis. A major factor in the capacity of cancer cell invasion is the activation of matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix. Salvia miltiorrhiza has been used as a promotion for blood circulation to remove blood stasis. Numerous previous studies have demonstrated that S. miltiorrhiza extracts (SME) decrease lipid levels and inhibit inflammation. However, the mechanism behind the effect of SME on breast cancer invasion has not been identified...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926605/assessment-of-common-somatic-mutations-of-egfr-kras-braf-nras-in-pulmonary-non-small-cell-carcinoma-using-iplex%C3%A2-hs-a-new-highly-sensitive-assay-for-the-massarray%C3%A2-system
#2
Bobbie C Sutton, Ryan T Birse, Kevin Maggert, Tammy Ray, Jessica Hobbs, Amobi Ezenekwe, Jason Kazmierczak, Michael Mosko, Joan Kish, Andrew Bullock, Zonggao Shi, M Sharon Stack, Darryl Irwin
Increased early detection and personalized therapy for lung cancer have coincided with greater use of minimally invasive sampling techniques such as endobronchial ultrasound-guided biopsy (EBUS), endoscopic ultrasound-guided biopsy (EUS), and navigational biopsy, as well as thin needle core biopsies. As many lung cancer patients have late stage disease and other comorbidities that make open surgical procedures hazardous, the least invasive biopsy technique with the highest potential specimen yield is now the preferred first diagnostic study...
2017: PloS One
https://www.readbyqxmd.com/read/28926371/residential-agricultural-pesticide-exposures-and-risks-of-spontaneous-preterm-birth
#3
Gary M Shaw, Wei Yang, Eric M Roberts, Susan E Kegley, David K Stevenson, Suzan L Carmichael, Paul B English
BACKGROUND: Pesticides exposures are aspects of the human exposome that have not been sufficiently studied for their contribution to risk for preterm birth. We investigated risks of spontaneous preterm birth from potential residential exposures to 543 individual chemicals and 69 physicochemical groupings that were applied in the San Joaquin Valley of California during the study period, 1998-2011. METHODS: The study population was derived from birth certificate data linked with Office of Statewide Health Planning and Development maternal and infant hospital discharge data...
September 18, 2017: Epidemiology
https://www.readbyqxmd.com/read/28926234/using-ultra-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-based-chemometrics-for-the-identification-of-anti-angiogenic-biflavonoids-from-edible-garcinia-species
#4
Ping Li, Grace Gar-Lee Yue, Hin-Fai Kwok, Chun-Lin Long, Clara Bik-San Lau, Edward J Kennelly
Garcinia xanthochymus fruits are edible and also used in traditional medicine. Our previous work showed that the isolated natural products from G. xanthochymus fruits have displayed antioxidant activity and cytotoxicity in the colon cancer cells. In this study, we developed a strategy to correlate a zebrafish angiogenesis assay with ultra-performance liquid chromatography quadrupole time of flight mass spectrometry-based chemometric analysis to identify potential anti-angiogenic activity compounds from G. xanthochymus fruits...
September 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28924740/abstracts-geer-2017-san-sebastian-spain
#5
(no author information available yet)
No abstract text is available yet for this article.
September 18, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28924484/diabetic-ketoacidosis-producing-extreme-hyperkalemia-in-a-patient-with-type-1-diabetes-on-hemodialysis
#6
Hodaka Yamada, Shunsuke Funazaki, Masafumi Kakei, Kazuo Hara, San-E Ishikawa
Diabetic ketoacidosis (DKA) is a critical complication of type 1 diabetes associated with water and electrolyte disorders. Here, we report a case of DKA with extreme hyperkalemia (9.0 mEq/L) in a patient with type 1 diabetes on hemodialysis. He had a left frontal cerebral infarction resulting in inability to manage his continuous subcutaneous insulin infusion pump. Electrocardiography showed typical changes of hyperkalemia, including absent P waves, prolonged QRS interval and tented T waves. There was no evidence of total body water deficit...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28923815/use-of-complementary-health-approaches-among-diverse-primary-care-patients-with-type-2-diabetes-and-association-with-cardiometabolic-outcomes-from-the-sf-bay-collaborative-research-network-sf-bay-crn
#7
Margaret A Handley, Judy Quan, Maria T Chao, Neda Ratanawongsa, Urmimala Sarkar, Sophia Emmons-Bell, Dean Schillinger
PURPOSE: To describe use of complementary health approaches (CHAs) among patients with type 2 diabetes, and independent associations between CHA use and Hemoglobin A1c (A1C) and lower-density lipoprotein (LDL) cholesterol. METHODS: Participants were enrolled onto the SMARTSteps Program, a diabetes self-management support program conducted between 2009 and 2013 in San Francisco. At the 6-month interview, CHA use in the prior 30 days was estimated using a 12-item validated instrument...
September 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28923477/-surgical-intervention-in-a-108-year-old-male-with-hip-fracture-presentation-of-a-case
#8
Vicente Romero Estarlich, Nuria Montero Fernández, Sara Caro Bragado, Yasira Gracia de San Román, Jose Antonio Serra Rexach
No abstract text is available yet for this article.
September 15, 2017: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/28923065/the-heat-shock-response-in-neurons-and-astroglia-and-its-role-in-neurodegenerative-diseases
#9
REVIEW
Rebecca San Gil, Lezanne Ooi, Justin J Yerbury, Heath Ecroyd
Protein inclusions are a predominant molecular pathology found in numerous neurodegenerative diseases, including amyotrophic lateral sclerosis and Huntington's disease. Protein inclusions form in discrete areas of the brain characteristic to the type of neurodegenerative disease, and coincide with the death of neurons in that region (e.g. spinal cord motor neurons in amyotrophic lateral sclerosis). This suggests that the process of protein misfolding leading to inclusion formation is neurotoxic, and that cell-autonomous and non-cell autonomous mechanisms that maintain protein homeostasis (proteostasis) can, at times, be insufficient to prevent protein inclusion formation in the central nervous system...
September 18, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28922937/book-review-head-and-neck-ultrasonography-essential-and-extended-applications-orloff-lisa-a-head-and-neck-ultrasonography-essential-and-extended-applications-2nd-ed-san-diego-ca-plural-publishing-2017-hard-cover-illustrated-544-pages-299-95
#10
https://www.readbyqxmd.com/read/28922590/efficacy-and-safety-of-the-%C3%AE-7-nicotinic-acetylcholine-receptor-agonist-abt-126-in-the-treatment-of-cognitive-impairment-associated-with-schizophrenia-results-from-a-phase-2b-randomized-controlled-study-in-smokers
#11
George M Haig, Deli Wang, Jun Zhao, Ahmed A Othman, Earle E Bain
OBJECTIVE: To evaluate the efficacy and safety of the α₇-nicotinic receptor agonist ABT-126 for treatment of cognitive impairment in stable subjects with schizophrenia who smoke. METHODS: A 12-week double-blind, placebo-controlled, parallel-group study was conducted from August 2012 to March 2014. Subjects with a diagnosis of schizophrenia based on DSM-IV-TR criteria (confirmed by the Mini-International Neuropsychiatric Interview version 6.0.0) were randomized 1:1:1 to ABT-126 25 mg, ABT-126 75 mg, or placebo once daily while maintained on their background antipsychotic medication...
September 12, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28922420/stable-c-and-n-isotope-analysis-of-hair-suggest-undernourishment-as-a-factor-in-the-death-of-a-mummified-girl-from-late-19th-century-san-francisco-ca
#12
Jelmer W Eerkens, Bryna Hull, Jena Goodman, Angela Evoy, Joshua D Kapp, Sidra Hussain, Richard E Green
The chance discovery of a 1.5-3.5 years old mummified girl presents a unique opportunity to further our understanding of health and disease among children in 19th Century San Francisco. This study focuses on carbon and nitrogen stable isotope signatures in serial samples of hair that cover the last 14 months of her life. Results suggest an initial omnivorous diet with little input from marine resources or C4 plants. Around six months before death δ15N starts a steady increase, with a noticeable acceleration just two months before she died...
2017: PloS One
https://www.readbyqxmd.com/read/28922264/validation-of-a-portable-coagulometer-for-routine-in-hospital-use-for-newborns
#13
Antonio E Jerez Calero, Dolores Fernández Jiménez, Manuel Molina Oya, Eduardo Narbona López, José Uberos Fernández
OBJECTIVES: To verify the reliability and clinical benefits of the coagulation tests made by a point of care device in newborn admitted to a neonatal unit. DESIGN: We made a statistical comparison between results obtained by the point of care device versus conventional laboratory analysis. SETTING: Level 3 neonatal unit. PATIENTS: Thirty-one infants admitted to the neonatal unit at the San Cecilio University Hospital (Granada, Spain) were recruited to this study...
September 15, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28921169/effects-of-acute-salt-stress-on-modulation-of-gene-expression-in-a-malaysian-salt-tolerant-indigenous-rice-variety-bajong
#14
Brandon Pei Hui Yeo, Mrinal Bhave, Siaw San Hwang
The small genome size of rice relative to wheat and barley, together with its salt sensitivity, make it an ideal candidate for studies of salt stress response. Transcriptomics has emerged as a powerful technique to study salinity responses in many crop species. By identifying a large number of differentially expressed genes (DEGs) simultaneously after the stress induction, it can provide crucial insight into the immediate responses towards the stressor. In this study, a Malaysian salt-tolerant indigenous rice variety named Bajong and one commercial rice variety named MR219 were investigated for their performance in plant growth and ion accumulation properties after salt stress treatment...
September 18, 2017: Journal of Plant Research
https://www.readbyqxmd.com/read/28920960/long-noncoding-rna-egfr-as1-mediates-epidermal-growth-factor-receptor-addiction-and-modulates-treatment-response-in-squamous-cell-carcinoma
#15
Daniel S W Tan, Fui Teen Chong, Hui Sun Leong, Shen Yon Toh, Dawn P Lau, Xue Lin Kwang, Xiaoqian Zhang, Gopinath M Sundaram, Gek San Tan, Mei Mei Chang, Boon Tin Chua, Wan Teck Lim, Eng Huat Tan, Mei Kim Ang, Tony K H Lim, Prabha Sampath, Balram Chowbay, Anders J Skanderup, Ramanuj DasGupta, N Gopalakrishna Iyer
Targeting EGFR is a validated approach in the treatment of squamous-cell cancers (SCCs), although there are no established biomarkers for predicting response. We have identified a synonymous mutation in EGFR, c.2361G>A (encoding p.Gln787Gln), in two patients with head and neck SCC (HNSCC) who were exceptional responders to gefitinib, and we showed in patient-derived cultures that the A/A genotype was associated with greater sensitivity to tyrosine kinase inhibitors (TKIs) as compared to the G/A and G/G genotypes...
September 18, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28920518/the-indirect-costs-of-underfunding-foreign-partners-in-global-health-research-a-case-study
#16
Johanna T Crane, Irene Andia Biraro, Tamer M Fouad, Yap Boum, David R Bangsberg
This study of a global health research partnership assesses how U.S. fiscal administrative policies impact capacity building at foreign partner institutions. We conducted a case study of a research collaboration between Mbarara University of Science and Technology (MUST) in Mbarara, Uganda, and originally the University of California San Francisco (UCSF), but now Massachusetts General Hospital (MGH). Our case study is based on three of the authors' experiences directing and working with this partnership from its inception in 2003 through 2015...
September 16, 2017: Global Public Health
https://www.readbyqxmd.com/read/28919958/further-studies-on-boreonectes-angus-2010-with-a-molecular-phylogeny-of-the-palaearctic-species-of-the-genus
#17
Robert B Angus, Ignacio Ribera, Fenglong Jia
Karyotypes are given for Boreonectes emmerichi (Falkenström, 1936) from its type locality at Kangding, China, and for B. alpestris (Dutton & Angus, 2007) from the St Gotthard and San Bernardino passes in the Swiss Alps. A phylogeny based on sequence data from a combination of mitochondrial and nuclear genes recovered western Palaearctic species of Boreonectes as monophyletic with strong support. Boreonectes emmerichi was placed as sister to the north American forms of B. griseostriatus (De Geer, 1774), although with low support...
2017: Comparative Cytogenetics
https://www.readbyqxmd.com/read/28919592/the-study-on-the-lives-and-health-conditions-of-internees-in-santo-thomas-camp-of-philippines-based-on-mcanlis-s-the-war-in-manila-1941-1945
#18
Jueyeon Lee, Youngsoo Cho
When Japan invaded the Philippines, two missionary dentists (Dr. McAnlis and Dr. Boots) who were forced to leave Korea were captured and interned in the Santo Thomas camp in Manila. Japan continued to bombard and plunder the Philippines in the wake of the Pacific War following the Great East Asia policy, leading to serious inflation and material deficiency. More than 4,000 Allied citizens held in Santo Thomas camp without basic food and shelter. Santo Thomas Camp was equipped with the systems of the Japanese military medical officers and Western doctors of captivity based on the Geneva Conventions(1929)...
August 2017: Ŭi Sahak
https://www.readbyqxmd.com/read/28919441/a-unique-ph-dependent-recognition-of-methylated-histone-h3k4-by-pps-and-dido
#19
Adam H Tencer, Jovylyn Gatchalian, Brianna J Klein, Abid Khan, Yi Zhang, Brian D Strahl, Karel H M van Wely, Tatiana G Kutateladze
The protein partner of Sans-fille (PPS) and its human homolog DIDO mediate diverse chromatin activities, including the regulation of stemness genes in embryonic stem cells and splicing in Drosophila. Here, we show that the PHD fingers of PPS and DIDO recognize the histone mark H3K4me3 in a pH-dependent manner: the binding is enhanced at high pH values but is decreased at low pH. Structural analysis reveals that the pH dependency is due to the presence of a histidine residue in the K4me3-binding aromatic cage of PPS...
September 8, 2017: Structure
https://www.readbyqxmd.com/read/28919326/characterization-of-a-pkr-inhibitor-from-the-pathogenic-ranavirus-ambystoma-tigrinum-virus-using-a-heterologous-vaccinia-virus-system
#20
Trung P Huynh, James K Jancovich, Latha Tripuraneni, Michael C Heck, Jeffrey O Langland, Bertram L Jacobs
Ambystoma tigrinum virus (ATV) (family Iridoviridae, genus Ranavirus) was isolated from diseased tiger salamanders (Ambystoma tigrinum stebbinsi) from the San Rafael Valley in southern Arizona, USA in 1996. Genomic sequencing of ATV, as well as other members of the genus, identified an open reading frame that has homology to the eukaryotic translation initiation factor, eIF2α (ATV eIF2α homologue, vIF2αH). Therefore, we asked if the ATV vIF2αH could also inhibit PKR. To test this hypothesis, the ATV vIF2αH was cloned into vaccinia virus (VACV) in place of the well-characterized VACV PKR inhibitor, E3L...
September 14, 2017: Virology
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