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https://www.readbyqxmd.com/read/28404955/identification-of-skin-related-lncrnas-as-potential-biomarkers-that-involved-in-wnt-pathways-in-keloids
#1
Xiao-Jie Sun, Qiang Wang, Baofeng Guo, Xian-Ying Liu, Bing Wang
The long non-coding RNAs (lncRNAs) regulating encoding transcripts/genes involved in Wnt signalling pathway in keloids is largely unclear. We used a pathway-focused lncRNA microarray to detect the differentiated expression profiles of both lncRNAs and genes involved in Wnt pathway, thus a total of 116 Wnt-targeted genes and 69 Wnt-related lncRNAs aberrantly expressed in keloids were initially identified. A stepwise bioinformatics was further performed to find skin-related lncRNA/gene pairs in Wnt pathway in keloids...
March 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28403507/endothelial-dysfunction-and-mechanobiology-in-pathological-cutaneous-scarring-lessons-learned-from-soft-tissue-fibrosis
#2
REVIEW
C Huang, L Liu, Z You, Y Zhao, J Dong, Y Du, R Ogawa
Hypertrophic scars/keloids are pathogenic scars that are characterized by collagen and fibroblast accumulation. The endothelia in the lesions are mechanosensitive and participate actively in the pathogenesis of these scars. The present review summarizes how endothelium responds to mechanical stimuli such as shear, stretch, and hydrostatic pressure. It also shows that in heart, liver, kidney, and lung fibrosis, endothelial dysfunctions (EDs) associate with changes in vascular tone, endothelial permeability, coagulation, and vasomodulation that result in inflammation, hypertension, and coagulation...
April 12, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28403263/microneedling-in-all-skin-types-a-review
#3
Lauren Meshkov Bonati, Gorana Kuka Epstein, Tamara Lazic Strugar
<p>INTRODUCTION: Microneedling procedures are growing in popularity for a wide variety of skin conditions. This paper comprehensively reviews the medical literature regarding skin needling efficacy and safety in all skin types and in multiple dermatologic conditions.</p> <p>METHODS: A PubMed literature search was conducted in all languages without restriction and bibliographies of relevant articles reviewed. Search terms included: "microneedling," "percutaneous collagen induction," "needling," "skin needling," and "dermaroller...
April 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28400319/association-of-surgical-excision-and-brachytherapy-for-the-management-of-keloids
#4
N Sigaux, M Jacquemart, A S Cousin, F Lorchel, P Breton
No abstract text is available yet for this article.
April 8, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28392706/pancreatic-solitary-fibrous-tumor-in-a-toddler-managed-by-pancreaticoduodenectomy-a-case-report-and-review-of-the-literature
#5
Qingfeng Sheng, Weijue Xu, Jiangbin Liu, Baiyong Shen, Xiaxing Deng, Yibo Wu, Wei Wu, Shenghua Yu, Xueli Wang, Zhibao Lv
Solitary fibrous tumor (SFT) of the pancreas is rare, with 15 adult cases reported in the English literature. We described a 14-month-old boy who presented with obstructive jaundice. Dominantly elevated serum CA19-9 was detected. Imaging studies revealed a well-circumscribed, solid mass in the pancreatic head. A pancreaticoduodenectomy (child procedure) was performed using Shen's anastomosis technique. After resection of the tumor, liver function and serum tumor markers normalized and clinical signs receded...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28392641/low-level-light-therapy-with-410-nm-light-emitting-diode-suppresses-collagen-synthesis-in-human-keloid-fibroblasts-an-in-vitro-study
#6
Hyun Soo Lee, Soo-Eun Jung, Sue Kyung Kim, You-Sun Kim, Seonghyang Sohn, You Chan Kim
BACKGROUND: Keloids are characterized by excessive collagen deposition in the dermis, in which transforming growth factor β (TGF-β)/Smad signaling plays an important role. Low-level light therapy (LLLT) is reported as effective in preventing keloids in clinical reports, recently. To date, studies investigating the effect of LLLT on keloid fibroblasts are extremely rare. OBJECTIVE: We investigated the effect of LLLT with blue (410 nm), red (630 nm), and infrared (830 nm) light on the collagen synthesis in keloid fibroblasts...
April 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28388720/new-uses-of-abobotulinumtoxina-in-aesthetics
#7
Joel Schlessinger, Erin Gilbert, Joel L Cohen, Joely Kaufman
BotulinumtoxinA (BoNT-A) is now widely established for the main approved indication of reducing glabellar lines, and is also widely used off-label to improve the appearance of wrinkles and lines in other parts of the face. The number of aesthetic procedures continues to increase as the patient population becomes more diverse, in particular with increasing numbers of people of color and men. Further developments in treatment may continue to expand the audience for BoNT-A by making procedures more comfortable and by delivering a more natural, less static appearance...
May 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28375976/advancing-keloid-treatment-a-novel-multimodal-approach-to-ear-keloids
#8
Michael E Jones, Jennifer McLane, Rachael Adenegan, JoAnne Lee, Christine A Ganzer
BACKGROUND/OBJECTIVE: Management of keloids of the pinna, in particular, those located in the helix and antihelix and lobule that occur as complications of ear piercing. MATERIALS AND METHODS: Retrospective analysis of 49 patients treated with extralesional surgical excision of keloids localized to the ear followed by the application of autologous platelet-rich plasma (PRP) to wound site and postoperative in-office superficial radiation therapy (SRT). Radiation protocol consisted of 1 to 3 fractions, with cumulative dosage ranging from 1,300 to 1,800 cGy...
April 3, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28370943/hypochlorous-acid-gel-technology-its-impact-on-postprocedure-treatment-and-scar-prevention
#9
REVIEW
Michael H Gold, Anneke Andriessen, Steven H Dayan, Sabrina G Fabi, Z Paul Lorenc, Meagan-Helen Henderson Berg
BACKGROUND: A pre-and postprocedure regime aimed at prevention of infection, reduction of inflammation and risk of scarring, is to enable optimal outcomes. OBJECTIVES: The role of a hypochlorous acid containing spray and translucent scar gel formulation that combines modified silicon oil with hypochlorous acid, was explored for pre- and postprocedure treatment and scar management. METHODS: For this purpose a literature review was conducted to explore the value of the technology used in pre-and postprocedural regimes...
March 30, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28370679/secreted-factors-from-equine-mesenchymal-stromal-cells-diminish-the-effects-of-tgf-%C3%AE-1-on-equine-dermal-fibroblasts-and-alter-the-phenotype-of-dermal-fibroblasts-isolated-from-cutaneous-fibroproliferative-wounds
#10
Rebecca M Harman, Ivanna V Bihun, Gerlinde R Van de Walle
The prevalence of cutaneous fibroproliferative disorders (CFPDs) is high and almost exclusively occurs in humans (keloids and hypertrophic scars) and horses (exuberant granulation tissue), making the horse a valuable translational model for studies on prevention and treatment of human CFPDs. CFPDs arise as a result of dysregulated wound healing characterized by persistently high levels of cytokines, such as transforming growth factor beta 1 (TGF-β1), that contribute to excessive extracellular matrix deposition, and the physical disorganization of dermal fibroblasts...
April 1, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28367096/effects-of-photodynamic-therapy-using-yellow-led-light-with-concomitant-hypocrellin-b-on-apoptotic-signaling-in-keloid-fibroblasts
#11
Yongqing Hu, Chunmin Zhang, Shengli Li, Ya Jiao, Tonggang Qi, Guo Wei, Gangwen Han
Keloid is a common and refractory disease characterized by abnormal fibroblast proliferation and excessive deposition of extracellular matrix components. Hypocrellin B (HB) is a natural perylene quinone photosensitizer. In this experiment, we studied the effects of photodynamic therapy (PDT) using yellow light from light-emitting diode (LED) combined with HB on keloid fibroblasts (KFB) in vitro. Our results showed that HB-LED PDT treatment induced significant KFB apoptosis and decreased KFB cell viability. HB-LED PDT treatment lead to significant BAX upregulation and BCL-2 downregulation in KFB cells, which led to elevation of intracellular free Ca(2+) and activation of caspase-3...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28352322/effect-of-wubeizi-ointment-aqueous-solution-on-the-expression-of-type-i-and-iii-procollagen-genes-in-keloid-fibroblasts
#12
Xiao-Xiang Zhai, Ji-Cun Ding, Zhi-Ming Tang, Jing-Guo Li, Xiang-Hui Chen, Cui-Xia Zhang
We evaluated the effect of Wubeizi (WBZ) ointment on keloids. Keloid-derived fibroblast primary cultures were used to evaluate the effect of the different concentration of WBZ ointment on the expression of type I and III procollagen in keloid fibroblast primary cultures using dot blot assay. Type I and II precollagen cDNA probes labeled with non-radioactive digoxin were used for dot blot. Cell cultures were divided into 4 groups: The large dose group received 1 g/ml of WBZ, middle dose, and small dose groups received 0...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28346732/asiaticoside-hinders-the-invasive-growth-of-keloid-fibroblasts-through-inhibition-of-the-gdf-9-mapk-smad-pathway
#13
Xin Wu, Difei Bian, Yannong Dou, Zhunan Gong, Qian Tan, Yufeng Xia, Yue Dai
Higher expression of growth differentiation factor-9 (GDF-9) in keloids compared with hypertrophic scars and normal skin tissues has been reported recently. The present study was performed to investigate the role of GDF-9 in keloid pathogenesis, and to elucidate its implication for asiaticoside in the keloid management. The data showed that GDF-9 could enhance the proliferation, migration, and invasion of keloid fibroblasts (KFs), while it only slightly elevated collagen expression, indicating that the effect of GDF-9 was opposite to that of TGF-β1...
March 27, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28321844/keloids-on-the-ears
#14
Carolina Cabrera-Salom, Luis F González, Mariam Rolón, Boris F Sánchez
No abstract text is available yet for this article.
March 21, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28316288/donor-site-morbidities-resulting-from-conchal-cartilage-harvesting-in-rhinoplasty
#15
M Y Lan, J P Park, Y J Jang
OBJECTIVE: Conchal cartilage is frequently used in rhinoplasty, but donor site morbidity data are seldom reported. This study aimed to investigate the complications of conchal cartilage harvesting in rhinoplasty. METHODS: A retrospective chart review of 372 patients who underwent conchal cartilage harvesting for rhinoplasty was conducted. Data regarding patient demographics, types of nasal deformities, graft usage and complications were analysed. RESULTS: A total of 372 patients who underwent conchal cartilage harvesting for rhinoplasty were enrolled...
March 20, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28293527/the-use-of-silgel-stc-se-a-topical-silicone-gel-for-the-treatment-and-reduction-of-hypertrophic-and-keloid-scars
#16
Sharon A Stewart, Greig M G Dougall, Erica M Tafuro
BACKGROUND: A single-center study assessing the efficacy of Nagor's Silgel STC-SE silicone gel to reduce the appearance of hypertrophic and keloid scars. METHODS: A 16-week controlled study of 36 patients with hypertrophic or keloid scars. The subjects were divided between 2 cohorts: one assessing recently healed scars (<6 mo) and other assessing older scars (6 mo to 2 y). The efficacy of Silgel STC-SE on the scar was evaluated by skin hydration, skin moisture evaporation, skin elasticity, basic scar measurements, subjective patient questionnaire data, and image analysis...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28288795/suppression-of-transforming-growth-factor-beta1-expression-in-keloids-after-cryosurgery
#17
Sara M Awad, Sahar A Ismail, Doaa S Sayed, Abeer E Refaiy, Rania Makboul
The biological mechanism underlying cryosurgical treatment of keloids remains unclear. Transforming growth factor-beta1 (TGF-β1) has been implicated in the pathogenesis of keloids and was reported to be the target of several therapeutic modalities. However, the effect of cryosurgery on its expression in keloid tissue has not been yet investigated. In this study, 26 consecutive keloid patients were treated with cryosurgery for 2-6 sessions. Keloids were biopsied before starting cryosurgery and after two treatment sessions for the immunohistochemical evaluation of TGF-β1 expression...
April 2017: Cryobiology
https://www.readbyqxmd.com/read/28287424/keloid-and-hypertrophic-scars-are-the-result-of-chronic-inflammation-in-the-reticular-dermis
#18
REVIEW
Rei Ogawa
Keloids and hypertrophic scars are caused by cutaneous injury and irritation, including trauma, insect bite, burn, surgery, vaccination, skin piercing, acne, folliculitis, chicken pox, and herpes zoster infection. Notably, superficial injuries that do not reach the reticular dermis never cause keloidal and hypertrophic scarring. This suggests that these pathological scars are due to injury to this skin layer and the subsequent aberrant wound healing therein. The latter is characterized by continuous and histologically localized inflammation...
March 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28276195/nodular-colloid-milium-mimicking-keloid
#19
Seyyede Zeinab Azimi, Omid Zargari, Robert I Rudolph
Colloid milium is a rare cutaneous deposit disease that usually presents clinically by the development of yellowish translucent or flesh-colored papules or plaques on sun-exposed skin. Histologically, it is characterized by the presence of colloid in the dermal papillae. In this case report, we present a 52-year-old man who presented with a nodule on his upper lip that mistakenly was diagnosed and treated as keloid.
March 9, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28257480/site-specific-gene-expression-profiling-as-a-novel-strategy-for-unravelling-keloid-disease-pathobiology
#20
N Jumper, T Hodgkinson, R Paus, A Bayat
Keloid disease (KD) is a fibroproliferative cutaneous tumour characterised by heterogeneity, excess collagen deposition and aggressive local invasion. Lack of a validated animal model and resistance to a multitude of current therapies has resulted in unsatisfactory clinical outcomes of KD management. In order to address KD from a new perspective, we applied for the first time a site-specific in situ microdissection and gene expression profiling approach, through combined laser capture microdissection and transcriptomic array...
2017: PloS One
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