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Keloids

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https://www.readbyqxmd.com/read/28726006/microrna-21-in-skin-fibrosis-potential-for-diagnosis-and-treatment
#1
REVIEW
Yan Li, Juan Zhang, Yuying Lei, Lechun Lyu, Ruiling Zuo, Ting Chen
Skin fibrosis is a common pathological process characterized by fibroblast proliferation and excessive deposition of extracellular matrix. However, the pathogenesis of the disease is still not clear. Previous studies have shown that microRNA-21 may play pivotal roles in the regulation of a variety of skin fibrosis, including keloid, scleroderma, and hypertrophic scar. In this review, we outline the structure, expression, and regulation of microRNA-21 and its role in fibrotic skin diseases. In future, it may be useful as a prognostic or diagnostic marker...
July 19, 2017: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/28720118/inhibiting-function-of-human-fetal-dermal-mesenchymal-stem-cells-on-bioactivities-of-keloid-fibroblasts
#2
Ya Jiao, Xiao Wang, Jixun Zhang, Yongjun Qi, Hongmin Gong, Duyin Jiang
BACKGROUND: Keloid is one kind of benign skin disease caused by hyperplasia of fibroblasts and collagen fibrils. It is refractory due to the lack of an effective treatment at present, which puts pressure on seeking a new therapeutic regimen. Mesenchymal stem cells (MSCs) from fetal skin are considered to play a crucial role in scarless healing. Nevertheless, the efficacy of them in keloid disorders remains poorly understood. METHODS: Keloid fibroblasts (KFs), human adult dermal fibroblasts (ADFs), and human fetal dermal mesenchymal stem cells (FDMSCs) were isolated to single cells and cultured in Dulbecco's modified Eagle's medium (DMEM)...
July 18, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28690124/microneedling-where-do-we-stand-now-a-systematic-review-of-the-literature
#3
REVIEW
Ramaut Lisa, Hoeksema Henk, Pirayesh Ali, Stillaert Filip, Monstrey Stan
BACKGROUND: Patients who suffer from scars or wrinkles have several therapeutic options to improve the appearance of their skin. The available treatment modalities that provide desirable results are often overtly invasive and entail a risk of undesirable adverse effects. Microneedling has recently emerged as a non-ablative alternative for treating patients who are concerned with the aesthetic changes that result from injury, disease or ageing. OBJECTIVE: This review aims to evaluate the current evidence in the literature on microneedling...
June 17, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28685723/radiation-therapy-in-keloids-treatment-history-strategy-effectiveness-and-complication
#4
REVIEW
Jing Xu, Elan Yang, Nan-Ze Yu, Xiao Long
OBJECTIVE: Radiation therapy combined with surgical excision was considered as one of the most effective treatment plans for keloid lesions. However, there was no unanimity found over present literatures regarding the issue on optimized treatment strategy for keloids. We here provide a comprehensive review over this issue and emphasize on the influencing factors. DATA SOURCES: The data analyzed in this review were searched from articles included in PubMed and EMBASE databases...
July 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28664654/acne-keloidalis-nuchae-risk-factors-and-associated-disorders-a-retrospective-study
#5
Althea D C East-Innis, Kaderina Stylianou, Alexandra Paolino, Jonathan D Ho
BACKGROUND: Acne keloidalis nuchae (AKN) is a chronic scarring folliculitis which usually occurs in young adult males of African descent. Studies have suggested that AKN may be associated with other dermatologic conditions and even general medical disorders. The aim of this study was to identify cutaneous and extracutaneous associated disorders and to examine risk factors in our population for developing AKN. METHODS: The study was a retrospective, descriptive, and analytical study conducted at the Dermatology Outpatient department of the University Hospital of the West Indies...
August 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28658462/isotretinoin-and-timing-of-procedural-interventions-a-systematic-review-with-consensus-recommendations
#6
Leah K Spring, Andrew C Krakowski, Murad Alam, Ashish Bhatia, Jeremy Brauer, Joel Cohen, James Q Del Rosso, Lucia Diaz, Jeffrey Dover, Lawrence F Eichenfield, Geoffrey C Gurtner, C William Hanke, Marla N Jahnke, Kristen M Kelly, Shilpi Khetarpal, Megan A Kinney, Moise L Levy, James Leyden, Michael T Longaker, Girish S Munavalli, David M Ozog, Heidi Prather, Peter R Shumaker, Elizabeth Tanzi, Abel Torres, Mara Weinstein Velez, Abigail B Waldman, Albert C Yan, Andrea L Zaenglein
Importance: The notion that systemic isotretinoin taken within 6 to 12 months of cutaneous surgery contributes to abnormal scarring or delayed wound healing is widely taught and practiced; however, it is based on 3 small case series from the mid-1980s. Objective: To evaluate the body of literature to provide evidence-based recommendations regarding the safety of procedural interventions performed either concurrently with, or immediately following the cessation of systemic isotretinoin therapy...
June 28, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28656880/downregulation-of-%C3%AE-catenin-blocks-fibrosis-via-wnt2-signaling-in-human-keloid-fibroblasts
#7
Yumei Cai, Shize Zhu, Weiqun Yang, Mingmeng Pan, Chaoyang Wang, Wenyi Wu
Keloid is a disorder of fibroproliferative diseases that occurs in wounds, characterized by an exaggerated response to injury. The key factor responsible for the disease process has not been identified. This study sought to elucidate the role of β-catenin in the regulation of keloid phenotypes and signaling. Expression of β-catenin in keloid and normal non-keloid samples was measured by real-time polymerase chain reaction. Knockdown of β-catenin was achieved by delivering small interfering RNA to target β-catenin...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28648517/-umbilical-endometriosis-mimicking-a-keloid-in-a-young-black-woman-a-case-report
#8
H-S Kourouma, E-J Ecra, A-S Allou, M Kouyaté, Y-I Kouassi, M Kaloga, K-A Kouassi, K Kassi, K Kouamé, C Ahogo, I-P Gbery, A Sangaré
BACKGROUND: Most umbilical tumors are diagnosed as benign tumors, umbilical metastases of abdominal and pelvic tumors, or Sister Marie Joseph nodule. Herein, we report a case of cutaneous umbilical endometriosis mistaken for a keloid. PATIENTS AND METHODS: A young black woman aged 26 consulted for a painful umbilical tumefaction. She had noted the appearance of a nodule of the umbilicus 10 months ago with bleeding during her menstrual periods. Skin examination revealed a firm and painful umbilical nodule 2...
June 22, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28638180/in-situ-cytokine-expression-and-morphometric-evaluation-of-total-collagen-and-collagens-type-i-and-type-iii-in-keloid-scars
#9
Isabela Rios da Silva, Luciana Colombo Rodrigues da Cunha Tiveron, Marcos Vinicius da Silva, Alberto Borges Peixoto, Carla Aparecida Xavier Carneiro, M A Dos Reis, Pedro Carvalho Furtado, Bárbara Rocha Rodrigues, Virmondes Rodrigues, Denise Bertulucci Rocha Rodrigues
Keloids are characterized by excessive collagen deposition and growth beyond the edges of the initial injury, and cytokines may be related to their formation. The objective of this study was to evaluate the collagen fibers, analyze in situ expression of cytokines in keloid lesions, and compare to the control group. Results showed that there was a predominance of women and nonwhite and direct black ancestry. Keloid showed a significant increase in total and type III collagen. Significantly, the expression of mRNA for TGF-β in keloid was increased, the expressions of IFN-γ, IFN-γR1, and IL-10 were lower, and IFN-γR1 and TNF-α had no statistical difference...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28621443/noninvasive-treatment-of-keloid-using-customized-re-188-skin-patch
#10
Priya Bhusari, Jaya Shukla, Munish Kumar, Rakhee Vatsa, Anupriya Chhabra, Kanchan Palarwar, Yogesh Rathore, Dipanker De, Sendhil Kumaran, Sanjeev Handa, B R Mittal
Keloids are developed as fibrotic scar at the site of surgery or trauma and often enlarge beyond the original scar margins. Re-188 colloid coated customized patch was superficially fixed onto the lesion for 3 hrs. The same patch was reapplied on the lesion on third day for 3 hrs. The patients were followed up at 1, 3,6 and 12 months post treatment. The size and elevation of the keloid lesion was reduced after treatment. The total radiation dose from the patch (day-1 and day-3) was 100 Gy/mCi of Re-188. The radioactive patch treatment of keloids is noninvasive, painless and safe with prolonged outcome...
June 16, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28619509/mir-141-3p-inhibits-fibroblast-proliferation-and-migration-by-targeting-gab1-in-keloids
#11
Jingjuan Feng, Siliang Xue, Qiuyu Pang, Zhen Rang, Fan Cui
Keloids are benign dermal fibroproliferative tumors that develop as a result of several dysregulated processes. Emerging evidence has revealed that miRNAs contribute to keloid formation. However, the molecular mechanisms of keloid pathogenesis remain unclear. In our study, we found that miR-141-3p in keloid tissues and keloid fibroblasts was significantly decreased compared with the levels in normal tissues and normal skin fibroblasts, respectively. miR-141-3p overexpression resulted in significantly decreased proliferation and migration and the promotion of apoptosis in keloid fibroblasts, whereas miR-141-3p knockdown in keloid fibroblasts yielded the opposite results...
August 19, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28607862/a-case-of-keloids-complicated-by-castleman-s-disease-interleukin-6-as-a-keloid-risk-factor
#12
Whitney L Quong, Yasuji Kozai, Rei Ogawa
Keloids are a manifestation of a fibroproliferative scarring disorder of the skin and develop in response to dermal injury in patients with a susceptible background. Local, systemic, and genetic factors contribute to keloid susceptibility. These factors include tension on the edges of the wound, hormonal influences, and ethnicity, respectively. Castleman's disease is a rare lymphoproliferative disorder that is characterized by the unregulated overproduction of interleukin-6, which leads to systemic lymphadenopathy and constitutional inflammatory symptoms...
May 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28607859/measurement-of-pressure-in-compressive-magnet-therapy-for-auricular-keloids
#13
Joshua A David, Salim A Ghodbane, Michael Chee, Henry C Hsia
No abstract text is available yet for this article.
May 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28588688/combined-effects-of-long-pulsed-neodymium-yttrium-aluminum-garnet-laser-diprospan-and-5-fluorouracil-in-the-treatment-of-keloid-scars
#14
Xiao-E Chen, Juan Liu, Afzaal Ahmed Bin Jameel, Maya Valeska, Jia-An Zhang, Yang Xu, Xing-Wu Liu, Hong Zhou, Dan Luo, Bing-Rong Zhou
Keloids are benign tumors that originate from scar tissues, but they usually overgrow beyond the original wounds. In a three-month single-center clinical trial, 69 patients were randomly divided into three groups. Patients in group 1 were treated with intralesional injection of diprospan (2 mg betamethasone disodium phosphate and 5 mg betamethasone dipropionate in 1 ml) with one-month intervals for three months. Patients in groups 2 and 3 were injected with a combination of 0.5 ml 5-fluorouracil (5-FU; 25 mg/ml) and diprospan as above for three months also...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28576531/the-clinical-efficacy-of-early-intervention-for-infected-preauricular-sinus
#15
Oak-Sung Choo, Top Kim, Jeong Hun Jang, Yun-Hoon Choung
OBJECTIVE: The study was designed to evaluate the outcomes of early surgical intervention, and to suggest the accurate operation time and surgical strategies. METHODS: A total of 190 cases (144 patients) of PAS excision were classified into 2 groups according to their time of surgery; early intervention group (n = 53), and non-early intervention group (n = 137). Early intervention was defined as excision performed within 3 weeks from their first hospital visit, and after acute infection control, surgical removal was followed regardless of their infection status...
April 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28570253/review-of-silicone-gel-sheeting-and-silicone-gel-for-the-prevention-of-hypertrophic-scars-and-keloids
#16
Kuei-Chang Hsu, Chih-Wei Luan, Yi-Wen Tsai
BACKGROUND: Keloids and hypertrophic scars are fibroproliferative disorders of dermal tissue after skin injury. Many clinical control studies have reported evidence that silicone gel is effective in preventing and alleviating hypertrophic scarring. Whether silicone gel sheeting prevents hypertrophic scars or keloids requires clear evidence of its clinical effectiveness. OBJECTIVE: This review investigated the effectiveness of silicone gel and silicone gel sheeting for the prevention of hypertrophic or keloid scarring in patients with newly healed wounds...
May 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28566904/arborizing-vessels-on-dermoscopy-in-various-skin-diseases-other-than-basal-cell-carcinoma
#17
Hyunju Jin, Min-Young Yang, Jeong-Min Kim, Gun-Wook Kim, Hoon-Soo Kim, Hyun-Chang Ko, Byung-Soo Kim, Moon-Bum Kim
BACKGROUND: Arborizing vessels (AVs) are dermoscopically defined as telangiectasias with distinct treelike branching, and are a characteristic feature of basal cell carcinoma (BCC). However, AVs are observed in various conditions other than BCC. OBJECTIVE: The aim of this study was to investigate skin diseases showing AV and investigates dermoscopic differences between BCC and non-BCC. METHODS: Dermoscopic images showing AV were prospectively collected and classified into BCC/non-BCC...
June 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28538876/combination-therapy-with-butyrate-and-docosahexaenoic-acid-for-keloid-fibrogenesis-an-in-vitro-study
#18
Kazuhiro Torii, Noriaki Maeshige, Michiko Aoyama-Ishikawa, Makoto Miyoshi, Hiroto Terashi, Makoto Usami
Background: A single, effective therapeutic regimen for keloids has not been established yet, and the development of novel therapeutic approaches is expected. Butyrate, a short-chain fatty acid, and docosahexaenoic acid (DHA), a ω-3 polyunsaturated fatty acid, play multiple anti-inflammatory and anticancer roles via their respective mechanisms of action. Objective: In this study, we evaluated the antifibrogenic effects of their single and combined use on keloid fibroblasts...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28515727/basics-of-radiation-biology-when-treating-hyperproliferative-benign-diseases
#19
REVIEW
Franz Rödel, Claudia Fournier, Julia Wiedemann, Felicitas Merz, Udo S Gaipl, Benjamin Frey, Ludwig Keilholz, M Heinrich Seegenschmiedt, Claus Rödel, Stephanie Hehlgans
For decades, low- and moderate-dose radiation therapy (RT) has been shown to exert a beneficial therapeutic effect in a multitude of non-malignant conditions including painful degenerative muscoloskeletal and hyperproliferative disorders. Dupuytren and Ledderhose diseases are benign fibroproliferative diseases of the hand/foot with fibrotic nodules and fascial cords, which determine debilitating contractures and deformities of fingers/toes, while keloids are exuberant scar formations following burn damage, surgery, and trauma...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28515622/the-influence-of-genistein-on-free-radicals-in-normal-dermal-fibroblasts-and-keloid-fibroblasts-examined-by-epr-spectroscopy
#20
Magdalena Jurzak, Paweł Ramos, Barbara Pilawa
Normal and keloid fibroblasts were examined using X-band (9.3 GHz) electron paramagnetic resonance spectroscopy. The effect of genistein on the concentration of free radicals in both normal dermal and keloid fibroblasts after ultraviolet irradiation was investigated. The highest concentration of free radicals was seen in keloid fibroblasts, with normal fibroblasts containing a lower concentration. The concentration of free radicals in both normal and keloid fibroblasts was altered in a concentration-dependent manner by the presence of genistein...
2017: Medicinal Chemistry Research
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