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Enamel regeneration

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https://www.readbyqxmd.com/read/28346861/biomimetic-remineralization-of-carious-lesions-by-self-assembling-peptide
#1
L Kind, S Stevanovic, S Wuttig, S Wimberger, J Hofer, B Müller, U Pieles
Caries is the most common disease in the world. Great efforts have been undertaken for prevention and to identify a regenerative treatment solution for dental caries. Self-assembling β-sheet forming peptides have previously shown to form 3-dimensional fiber networks supporting tissue regeneration. In particular, the self-assembling peptide P11-4 has shown potential in the treatment and prevention of dental caries. It has previously been shown that application of monomeric P11-4 solution to early carious lesions can increase net mineral gain by forming de novo hydroxyapatite crystals...
March 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28304211/furcation-therapy-with-enamel-matrix-derivative-effects-on-the-subgingival-microbiome
#2
Lucas A Queiroz, Renato C V Casarin, Shareef M Dabdoub, Dimitris N Tatakis, Enilson A Sallum, Purnima S Kumar
BACKGROUND: Although enamel matrix derivative (EMD) has been used to promote periodontal regeneration, little is known of its effect on the microbiome. Therefore, this investigation aimed to identify the changes in periodontal microbiome following treatment with EMD using a deep-sequencing approach. METHODS: Thirty-nine patients having mandibular class II buccal furcation defects were randomized to beta-tricalcium-phosphate/hydroxyapatite graft (BONE group), EMD+BONE or EMD alone...
March 17, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28287572/rapid-mix-preparation-of-bioinspired-nanoscale-hydroxyapatite-for-biomedical-applications
#3
Caroline J Wilcock, Piergiorgio Gentile, Paul V Hatton, Cheryl A Miller
Hydroxyapatite (HA) has been widely used as a medical ceramic due to its good biocompatibility and osteoconductivity. Recently there has been interest regarding the use of bioinspired nanoscale hydroxyapatite (nHA). However, biological apatite is known to be calcium-deficient and carbonate-substituted with a nanoscale platelet-like morphology. Bioinspired nHA has the potential to stimulate optimal bone tissue regeneration due to its similarity to bone and tooth enamel mineral. Many of the methods currently used to fabricate nHA both in the laboratory and commercially, involve lengthy processes and complex equipment...
February 23, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28261800/on-the-discovery-of-cementum
#4
REVIEW
B L Foster
Though cementum of the tooth root is critical for periodontal structure and tooth attachment and function, this tissue was not discovered and characterized on human teeth until a full century later than enamel and dentin. Early observations from the seventeenth to the nineteenth centuries by Marcello Malpighi, Antonie van Leeuwenhoek, Robert Blake, Jacques Tenon and Georges Cuvier founded a confusing and conflicting nomenclature that obscured the nature of cementum, often conflating it with bone. Advances in microscopy and histological procedures yielded the first detailed descriptions of human cementum in the 1830s by Jan Purkinje and Anders Retzius, who identified for the first time acellular and cellular types of cementum, and the resident cementocytes embedded in the latter...
March 6, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28196163/entire-papilla-preservation-technique-a-novel-surgical-approach-for-regenerative-treatment-of-deep-and-wide-intrabony-defects
#5
Serhat Aslan, Nurcan Buduneli, Pierpaolo Cortellini
Primary wound closure and uneventful early wound stability over the biomaterials are the most critical elements of successful periodontal regeneration. Yet the surgical elevation of the interdental papilla to access deep and wide intrabony defects entails an impairment of the papillary blood supply that can result in difficult healing due to a lack of primary closure in the early healing period. This negative event might complicate the healing process, favoring bacterial contamination. A novel modified tunnel surgical technique designed to maintain the integrity of the interdental papilla is presented in this article, with the aim of providing an optimal environment for wound healing in regenerative procedures...
March 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28186646/re-evaluation-of-the-adjunctive-effect-of-platelet-rich-fibrin-to-enamel-matrix-derivative-in-the-treatment-of-intrabony-defects-six-month-results-of-a-randomized-split-mouth-controlled-clinical-study
#6
Eralp Buduneli, Nurcan Buduneli
We have read with great interest the recent article by Turkal et al. (2016). In their study, the results obtained with enamel matrix derivative (EMD) and EMD + platelet-rich fibrin (PRF) were compared in the treatment of intrabony defects in patients with chronic periodontitis. The authors concluded that both therapies resulted in significant clinical improvement in intrabony defect treatment, but addition of PRF did not improve the clinical and radiographic outcomes. A recent review article provided the biological background for the use of EMD and discussed the current evidence for periodontal regeneration (Miron et al...
February 10, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28167823/in-vivo-remineralization-of-dentin-using-an-agarose-hydrogel-biomimetic-mineralization-system
#7
Min Han, Quan-Li Li, Ying Cao, Hui Fang, Rong Xia, Zhi-Hong Zhang
A novel agarose hydrogel biomimetic mineralization system loaded with calcium and phosphate was used to remineralize dentin and induce the oriented densely parallel packed HA layer on defective dentin surface in vivo in a rabbit model. Firstly, the enamel of the labial surface of rabbits' incisor was removed and the dentin was exposed to oral environment. Secondly, the hydrogel biomimetic mineralization system was applied to the exposed dentin surface by using a custom tray. Finally, the teeth were extracted and evaluated by scanning electron microscopy, X-ray diffraction, and nanoindentation test after a certain time of mineralization intervals...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28149456/preventive-effects-of-different-protective-agents-on-dentin-erosion-an-in-vitro-investigation
#8
Claudio Poggio, Chiara Gulino, Maria Mirando, Marco Colombo, Giampiero Pietrocola
BACKGROUND: The purpose of this in vitro study was to evaluate the preventive effects of different protective agents on dentine erosion, measuring mean percentage weight loss. Dissolution of dentine under erosive challenges caused by soft drinks was analyzed: specimens were weighed following each immersion period, with mean percent weight losses calculated. MATERIAL AND METHODS: Extracted teeth were sectioned into uniform slabs. Seventy permanent enamel specimens were randomly distributed to seven groups...
January 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28134829/early-healing-events-after-periodontal-surgery-observations-on-soft-tissue-healing-microcirculation-and-wound-fluid-cytokine-levels
#9
Doğan Kaner, Mouaz Soudan, Han Zhao, Georg Gaßmann, Anna Schönhauser, Anton Friedmann
Early wound healing after periodontal surgery with or without enamel matrix derivative/biphasic calcium phosphate (EMD/BCP) was characterized in terms of soft tissue closure, changes of microcirculation, and expression of pro- and anti-inflammatory cytokines in gingival crevicular fluid/wound fluid (GCF/WF). Periodontal surgery was carried out in 30 patients (18 patients: application of EMD/BCP for regeneration of bony defects; 12 patients: surgical crown lengthening (SCL)). Healthy sites were observed as untreated controls...
January 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28118552/decellularized-tooth-bud-scaffolds-for-tooth-regeneration
#10
W Zhang, B Vazquez, D Oreadi, P C Yelick
Whole tooth regeneration approaches currently are limited by our inability to bioengineer full-sized, living replacement teeth. Recently, decellularized organ scaffolds have shown promise for applications in regenerative medicine by providing a natural extracellular matrix environment that promotes cell attachment and tissue-specific differentiation leading to full-sized organ regeneration. We hypothesize that decellularized tooth buds (dTBs) created from unerupted porcine tooth buds (TBs) can be used to guide reseeded dental cell differentiation to form whole bioengineered teeth, thereby providing a potential off-the-shelf scaffold for whole tooth regeneration...
January 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28117776/development-of-a-direct-pulp-capping-model-for-the-evaluation-of-pulpal-wound-healing-and-reparative-dentin-formation-in-mice
#11
Minju Song, Sol Kim, Terresa Kim, Sil Park, Ki-Hyuk Shin, Mo Kang, No-Hee Park, Reuben Kim
Dental pulp is a vital organ of a tooth fully protected by enamel and dentin. When the pulp is exposed due to cariogenic or iatrogenic injuries, it is often capped with biocompatible materials in order to expedite pulpal wound healing. The ultimate goal is to regenerate reparative dentin, a physical barrier that functions as a "biological seal" and protects the underlying pulp tissue. Although this direct pulp-capping procedure has long been used in dentistry, the underlying molecular mechanism of pulpal wound healing and reparative dentin formation is still poorly understood...
January 12, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28113034/biomimetic-enamel-regeneration-mediated-by-leucine-rich-amelogenin-peptide
#12
S Y Kwak, A Litman, H C Margolis, Y Yamakoshi, J P Simmer
We report here a novel biomimetic approach to the regeneration of human enamel. The approach combines the use of inorganic pyrophosphate (PPi) to control the onset and rate of enamel regeneration and the use of leucine-rich amelogenin peptide (LRAP), a nonphosphorylated 56-amino acid alternative splice product of amelogenin, to regulate the shape and orientation of growing enamel crystals. This study builds on our previous findings that show LRAP can effectively guide the formation of ordered arrays of needle-like hydroxyapatite (HA) crystals in vitro and on the known role mineralization inhibitors, like PPi, play in the regulation of mineralized tissue formation...
January 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28104393/periodontal-tissue-regeneration-using-the-cytokine-cocktail-mimicking-secretomes-in-the-conditioned-media-from-human-mesenchymal-stem-cells
#13
Kohei Sakaguchi, Wataru Katagiri, Masashi Osugi, Takamasa Kawai, Yukiko Sugimura-Wakayama, Hideharu Hibi
Secretomes in the conditioned media from human mesenchymal stem cells (MSC-CM) were previously demonstrated to promote periodontal tissue regeneration. By mixing insulin-like growth factor-1, vascular endothelial growth factor-A, and transforming growth factor-β1 which were included in MSC-CM, we made the cytokine cocktail (CC) mimicking MSC-CM, and then evaluated its efficacy on periodontal tissue regeneration. In vitro, CC promoted the migration of dog bone marrow-derived stem cells and periodontal ligament cells, and the tube formation of human umbilical vein endothelial cells...
January 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28097682/evaluation-of-perforated-demineralized-dentin-scaffold-on-bone-regeneration-in-critical-size-sheep-iliac-defects
#14
Md Arafat Kabir, Masaru Murata, Toshiyuki Akazawa, Kaoru Kusano, Katsuhisa Yamada, Manabu Ito
OBJECTIVES: Regenerating critical-size bone injury is a major problem that continues to inspire the design of new graft materials. Therefore, tissue engineering has become a novel approach for targeting bone regeneration applications. Human teeth are a rich source of stem cells, matrix, trace metal ions, and growth factors. A vital tooth-derived demineralized dentin matrix is acid-insoluble and composed of cross-linked collagen with growth factors. In this study, we recycled human non-functional tooth into a unique geometric dentin scaffold, entitled perforated root-demineralized dentin matrix (PR-DDM)...
January 17, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28095524/combination-of-collagen-barrier-membrane-with-enamel-matrix-derivative-liquid-improves-osteoblast-adhesion-and-differentiation
#15
Richard J Miron, Masako Fujioka-Kobayashi, Daniel Buser, Yufeng Zhang, Dieter D Bosshardt, Anton Sculean
PURPOSE: Collagen barrier membranes were first introduced to regenerative periodontal and oral surgery to prevent fast ingrowing soft tissues (ie, epithelium and connective tissue) into the defect space. More recent attempts have aimed at combining collagen membranes with various biologics/growth factors to speed up the healing process and improve the quality of regenerated tissues. Recently, a new formulation of enamel matrix derivative in a liquid carrier system (Osteogain) has demonstrated improved physico-chemical properties for the adsorption of enamel matrix derivative to facilitate protein adsorption to biomaterials...
January 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28052551/remineralization-of-natural-early-caries-lesions-in-vitro-by-p11-4-monitored-with-photothermal-radiometry-and-luminescence
#16
Joshua D Silvertown, Bonny P Y Wong, Koneswaran S Sivagurunathan, Stephen H Abrams, Jennifer Kirkham, Bennett T Amaechi
AIM: The efficacy of self-assembling peptide P11 -4 to regenerate enamel in natural early caries lesions was evaluated over 50 days by photothermal radiometry and luminescence using The Canary System (CS) and The Canary Lab (CL). METHODS: Baseline readings for sound and carious sites on smooth surfaces of extracted teeth were obtained by scanning with CS and CL. Teeth were then randomly assigned to a treatment group (TG, treated with P11 -4), a placebo group (PG, same vehicle as treatment group without P11 -4), or a control group (CG, no treatment)...
January 4, 2017: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/27978604/effects-of-emd-liquid-osteogain-on-periodontal-healing-in-class-iii-furcation-defects-in-monkeys
#17
Yoshinori Shirakata, Richard J Miron, Toshiaki Nakamura, Kotaro Sena, Yukiya Shinohara, Naoto Horai, Dieter D Bosshardt, Kazuyuki Noguchi, Anton Sculean
AIM: To evaluate the effect of a novel liquid carrier system of enamel matrix derivative (Osteogain) soaked on an absorbable collagen sponge (ACS) upon periodontal wound healing/regeneration in furcation defects in monkeys. MATERIALS AND METHODS: The stability of the conventional enamel matrix derivative (Emdogain) and Osteogain adsorbed onto ACS was evaluated by ELISA. Chronic class III furcation defects were created at teeth 36, 37, 46, 47 in three monkeys (Macaca fascicularis)...
March 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27919683/effects-of-c-terminal-amelogenin-peptides-on-the-metabolism-of-osteoblasts
#18
Tetsuya Awada, Ryo Kunimatsu, Yuki Yoshimi, Naoto Hirose, Tomomi Mitsuyoshi, Keisuke Sumi, Kotaro Tanimoto
OBJECTIVES: Amelogenins, enamel matrix proteins secreted by ameloblasts, comprise 90% of the developing extracellular enamel matrix. Recent evidence suggests that amelogenins might induce the proliferation of various cells. However, the residues comprising the active site of amelogenin remain unclear. Therefore, this study aimed to examine the effects of a human amelogenin C-terminal peptide (amgCP) on the metabolism of osteoblasts. MATERIALS AND METHODS: Mouse calvarial osteoblastic cells (MC3T3-E1) were cultured and treated with amgCP...
January 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27790578/clinical-evaluation-of-insulin-like-growth-factor-i-and-vascular-endothelial-growth-factor-with-alloplastic-bone-graft-material-in-the-management-of-human-two-wall-intra-osseous-defects
#19
Renu Devi, Jaya Dixit
INTRODUCTION: In recent years, emphasis on the use of growth factors for periodontal healing is gaining great momentum. Several growth factors showed promising results in periodontal regeneration. AIM: This study was designed to compare the clinical outcomes of 0.8μg recombinant human Vascular Endothelial Growth Factor (rh-VEGF) and 10μg recombinant human Insulin Like Growth Factor-I (rh-IGF-I) with β-Tricalcium Phosphate (β-TCP) and Polylactide-Polyglycolide Acid (PLGA) membrane in two wall intra-osseous defects...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27740649/guided-tissue-regeneration-involving-piercing-induced-lingual-recession-a-case-report
#20
Carlos Parra, Y Natalie Jeong, Charles E Hawley
Recession on the lingual aspect of mandibular incisors may occur in patients with history of tongue piercing and other factitious traumatic habits. Treatment of these areas is challenging due to the site-specific anatomical features of the region. This case report presents a novel approach for a specific type of mandibular lingual defect caused by tongue piercing. A nonresorbable titanium-reinforced barrier membrane combined with an allograft and enamel matrix derivatives was used to promote regeneration of periodontal attachment...
November 2016: International Journal of Periodontics & Restorative Dentistry
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