keyword
MENU ▼
Read by QxMD icon Read
search

Organelle communication

keyword
https://www.readbyqxmd.com/read/29332287/studying-retrograde-signaling-in-plants
#1
Martyna Broda, Olivier Van Aken
Cellular homeostasis requires precise communication between various types of organelles. In particular, the communication between nucleus and semiautonomous organelles, mitochondria and chloroplasts, has received widespread attention. Communication from nucleus to other organelles is known as anterograde signaling, whereas communication from mitochondria or chloroplasts to the nucleus is known as retrograde signaling. Here we discuss methods used to study retrograde signaling in Arabidopsis thaliana. These methods may also be modified to study retrograde signaling in other plant species...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29316440/putting-your-best-egg-forward
#2
Christopher K Patil, Vladimir Denic
In a recent issue of Nature, Bohnert and Kenyon (2017) describe a signaling pathway that prevents transgenerational inheritance of cytoplasmic protein aggregates. Fertilizing sperm trigger aggregate clearance in the ovum by a microautophagy-like effector mechanism mediated by inter-organelle communication between lysosomes and mitochondria.
January 8, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29305172/gastrointestinal-factors-regulating-lipid-droplet-formation-in-the-intestine
#3
REVIEW
N Auclair, L Melbouci, D St-Pierre, E Levy
Cytoplasmic lipid droplets (CLD) are considered as neutral lipid reservoirs, which protect cells from lipotoxicity. It became clear that these fascinating dynamic organelles play a role not only in energy storage and metabolism, but also in cellular lipid and protein handling, inter-organelle communication, and signaling among diverse functions. Their dysregulation is associated with multiple disorders, including obesity, liver steatosis and cardiovascular diseases. The central aim of this review is to highlight the link between intra-enterocyte CLD dynamics and the formation of chylomicrons, the main intestinal dietary lipid vehicle, after overviewing the morphology, molecular composition, biogenesis and functions of CLD...
January 2, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29281071/the-role-of-retrograde-signals-during-plant-stress-responses
#4
Tim Crawford, Nóra Lehotai, Åsa Strand
Chloroplast and mitochondria not only provide the energy to the plant cell but, due to the sensitivity of organellar processes to perturbations caused by abiotic stress, they are also key cellular sensors of environmental fluctuations. Abiotic stresses result in reduced photosynthetic efficiency and thereby reduced energy supply for cellular processes. Thus, in order to acclimate to stress, plants must re-program gene expression and cellular metabolism to divert energy from growth and developmental processes to stress responses...
December 21, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29250789/plant-microbe-interactions-organelles-and-the-cytoskeleton-in-action
#5
REVIEW
Eunsook Park, Alexander Nedo, Jeffrey L Caplan, Savithramma P Dinesh-Kumar
Contents Summary I. II. III. IV. V. VI. References SUMMARY: Plants have evolved a multilayered immune system with well-orchestrated defense strategies against pathogen attack. Multiple immune signaling pathways, coordinated by several subcellular compartments and interactions between these compartments, play important roles in a successful immune response. Pathogens use various strategies to either directly attack the plant's immune system or to indirectly manipulate the physiological status of the plant to inhibit an immune response...
December 18, 2017: New Phytologist
https://www.readbyqxmd.com/read/29222112/rheb-localized-on-the-golgi-membrane-activates-lysosome-localized-mtorc1-at-the-golgi-lysosome-contact-site
#6
Feike Hao, Kazuhiko Kondo, Takashi Itoh, Sumiko Ikari, Shigeyuki Nada, Masato Okada, Takeshi Noda
In response to amino acid supply, mTORC1, a master regulator of cell growth, is recruited to the lysosome and activated by a small GTPase, Rheb. However, the intracellular localization of Rheb is controversial. In this study, we showed that a significant portion of Rheb was localized on the Golgi but not on the lysosome. GFP-Rheb could activate mTORC1, even when forced to exclusively localize to the Golgi. Likewise, artificial recruitment of mTORC1 to the Golgi allowed its activation. Accordingly, the Golgi was in contact with the lysosome at the newly described Golgi lysosome contact site (GLCS)...
December 8, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29205928/recent-progress-in-micro-nanoreactors-toward-the-creation-of-artificial-organelles
#7
REVIEW
Maria Godoy-Gallardo, Maria J York-Duran, Leticia Hosta-Rigau
Artificial organelles created from a bottom up approach are a new type of engineered materials, which are not designed to be living but, instead, to mimic some specific functions inside cells. By doing so, artificial organelles are expected to become a powerful tool in biomedicine. They can act as nanoreactors to convert a prodrug into a drug inside the cells or as carriers encapsulating therapeutic enzymes to replace malfunctioning organelles in pathological conditions. For the design of artificial organelles, several requirements need to be fulfilled: a compartmentalized structure that can encapsulate the synthetic machinery to perform an enzymatic function, as well as a means to allow for communication between the interior of the artificial organelle and the external environment, so that substrates and products can diffuse in and out the carrier allowing for continuous enzymatic reactions...
December 4, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29203327/ros-induced-ros-release-in-plant-and-animal-cells
#8
Sara I Zandalinas, Ron Mittler
Reactive oxygen species (ROS) play a key signaling role in plant and animal cells. Among the many cellular mechanisms used to generate and transduce ROS signals, ROS-induced ROS release (RIRR) is emerging as an important pathway involved in different human pathologies and plant responses to environmental stress. RIRR is a process in which one cellular compartment or organelle generates or releases ROS, triggering the enhanced production or release of ROS by another compartment or organelle. It was initially described in animal cells and proposed to mediate mitochondria-to-mitochondria communication, but later expanded to include communication between mitochondria and plasma membrane-localized NADPH oxidases...
December 2, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29198439/mitochondrial-transfer-in-the-leukemia-microenvironment
#9
REVIEW
Emmanuel Griessinger, Ruxanda Moschoi, Giulia Biondani, Jean-François Peyron
The bone marrow microenvironment (BMME) is a complex ecosystem that instructs and protects hematopoietic stem cells (HSCs) and their malignant counterparts, the leukemia-initiating cells (LICs). Within the physical and functional crosstalk that takes place between HSCs, LICs, and the BMME, the transfer of organelles and of mitochondria in particular is an important new intercellular communication mode in addition to adhesion molecules, tunneling nanotubes (TNTs), and the paracrine secretion of cytokines, (onco)metabolites, and extracellular vesicles (EVs)...
December 2017: Trends in Cancer
https://www.readbyqxmd.com/read/29168399/vacuolar-atpase-as-a-possible-therapeutic-target-in-human-acute-myeloid-leukemia
#10
Elise Aasebø, Sushma Bartaula-Brevik, Maria Hernandez-Valladares, Øystein Bruserud
V-ATPase is a proton pump expressed both in the membrane of intracellular organelles (e.g. endosomes, lysosomes, Golgi structures) and the plasma membrane. It is an important regulator of organellar functions, intracellular molecular trafficking, intercellular communication and intracellular signaling. It is therefore considered as a possible therapeutic target in the treatment of human malignancies. Areas covered: Relevant publications were identified through literature searches in the PubMed database. We searched for original articles and reviews describing the possible importance of V-ATPase for leukemogenesis and chemosensitivity in human myeloid cells, especially acute myeloid leukemia (AML) cells...
November 23, 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/29164114/interorganelle-communication-between-mitochondria-and-the-endolysosomal-system
#11
REVIEW
Gonzalo Soto-Heredero, Francesc Baixauli, María Mittelbrunn
The function of mitochondria and lysosomes has classically been studied separately. However, evidence has now emerged of intense crosstalk between these two organelles, such that the activity or stress status of one organelle may affect the other. Direct physical contacts between mitochondria and the endolysosomal compartment have been reported as a rapid means of interorganelle communication, mediating lipid or other metabolite exchange. Moreover, mitochondrial derived vesicles can traffic obsolete mitochondrial proteins into the endolysosomal system for their degradation or secretion to the extracellular milieu as exosomes, representing an additional mitochondrial quality control mechanism that connects mitochondria and lysosomes independently of autophagosome formation...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29163229/cx43-isoform-gja1-20k-promotes-microtubule-dependent-mitochondrial-transport
#12
Ying Fu, Shan-Shan Zhang, Shaohua Xiao, Wassim A Basheer, Rachel Baum, Irina Epifantseva, TingTing Hong, Robin M Shaw
Connexin 43 (Cx43, encoded by GJA1) is a cell-cell communication gap junction protein expressed in all organ systems. It was recently found that GJA1 mRNA undergoes alternative translation to generate N-terminal truncated isoforms, of which GJA1-20k is the most abundant. Here we report a surprising finding that, unlike full length GJA1-43k, GJA1-20k has a strong tropism for mitochondria. Exploring function, we found that GJA1-20k appears to be an organelle chaperone and that overexpression of GJA1-20k is sufficient to rescue mitochondrial localization to the cell periphery upon exposure to hydrogen peroxide, which effectively limits the network fragmentation that occurs with oxidative stress...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29150402/network-science-of-biological-systems-at-different-scales-a-review
#13
REVIEW
Marko Gosak, Rene Markovič, Jurij Dolenšek, Marjan Slak Rupnik, Marko Marhl, Andraž Stožer, Matjaž Perc
Network science is today established as a backbone for description of structure and function of various physical, chemical, biological, technological, and social systems. Here we review recent advances in the study of complex biological systems that were inspired and enabled by methods of network science. First, we present research highlights ranging from determination of the molecular interaction network within a cell to studies of architectural and functional properties of brain networks and biological transportation networks...
November 3, 2017: Physics of Life Reviews
https://www.readbyqxmd.com/read/29143784/primary-cilium-dependent-signaling-mechanisms
#14
REVIEW
Rajasekharreddy Pala, Nedaa Alomari, Surya M Nauli
Primary cilia are hair-like organelles and play crucial roles in vertebrate development, organogenesis, health, and many genetic disorders. A primary cilium is a mechano-sensory organelle that responds to mechanical stimuli in the micro-environment. A cilium is also a chemosensor that senses chemical signals surrounding a cell. The overall function of a cilium is therefore to act as a communication hub to transfer extracellular signals into intracellular responses. Although intracellular calcium has been one of the most studied signaling messengers that transmit extracellular signals into the cells, calcium signaling by various ion channels remains a topic of interest in the field...
October 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29106371/3d-visualization-of-mitochondrial-solid-phase-calcium-stores-in-whole-cells
#15
Sharon Grayer Wolf, Yael Mutsafi, Tali Dadosh, Tal Ilani, Zipora Lansky, Ben Horowitz, Sarah Rubin, Michael Elbaum, Deborah Fass
The entry of calcium into mitochondria is central to metabolism, inter-organelle communication, and cell life/death decisions. Long-sought transporters involved in mitochondrial calcium influx and efflux have recently been identified. To obtain a unified picture of mitochondrial calcium utilization, a parallel advance in understanding the forms and quantities of mitochondrial calcium stores is needed. We present here the direct 3D visualization of mitochondrial calcium in intact mammalian cells using cryo-scanning transmission electron tomography (CSTET)...
November 6, 2017: ELife
https://www.readbyqxmd.com/read/29093569/implications-of-mitochondrial-network-organization-in-mitochondrial-stress-signalling-in-narp-cybrid-and-rho0-cells
#16
Jarosław Walczak, Małgorzata Partyka, Jerzy Duszyński, Joanna Szczepanowska
Mitochondrial dysfunctions lead to the generation of signalling mediators that influence the fate of that organelle. Mitochondrial dynamics and their positioning within the cell are important elements of mitochondria-nucleus communication. The aim of this project was to examine whether mitochondrial shape, distribution and fusion/fission proteins are involved in the mitochondrial stress response in a cellular model subjected to specifically designed chronic mitochondrial stress: WT human osteosarcoma cells as controls, NARP cybrid cells as mild chronic stress and Rho0 as severe chronic stress...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29092621/piecing-the-puzzle-together-the-central-role-of-ros-and-redox-hubs-in-chloroplast-retrograde-signaling
#17
Dario Leister
SIGNIFICANCE: Reactive oxygen species (ROS) and redox regulation are established components of chloroplast-nucleus retrograde signaling. Recent Advances: In recent years a complex array of putative retrograde signaling molecules and novel signaling pathways has emerged, including various metabolites, chloroplast translation, mobile transcription factors, calcium and links to the unfolded protein response (UPR). This critical mass of information now permits us to fit individual pieces into a larger picture and outline a few important stimuli and pathways...
November 1, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29089870/tunneling-nanotubes-and-gap-junctions-their-role-in-long-range-intercellular-communication-during-development-health-and-disease-conditions
#18
REVIEW
Jennifer Ariazi, Andrew Benowitz, Vern De Biasi, Monique L Den Boer, Stephanie Cherqui, Haifeng Cui, Nathalie Douillet, Eliseo A Eugenin, David Favre, Spencer Goodman, Karine Gousset, Dorit Hanein, David I Israel, Shunsuke Kimura, Robert B Kirkpatrick, Nastaran Kuhn, Claire Jeong, Emil Lou, Robbie Mailliard, Stephen Maio, George Okafo, Matthias Osswald, Jennifer Pasquier, Roel Polak, Gabriele Pradel, Bob de Rooij, Peter Schaeffer, Vytenis A Skeberdis, Ian F Smith, Ahmad Tanveer, Niels Volkmann, Zhenhua Wu, Chiara Zurzolo
Cell-to-cell communication is essential for the organization, coordination, and development of cellular networks and multi-cellular systems. Intercellular communication is mediated by soluble factors (including growth factors, neurotransmitters, and cytokines/chemokines), gap junctions, exosomes and recently described tunneling nanotubes (TNTs). It is unknown whether a combination of these communication mechanisms such as TNTs and gap junctions may be important, but further research is required. TNTs are long cytoplasmic bridges that enable long-range, directed communication between connected cells...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29049733/tunneling-nanotubes-are-novel-cellular-structures-that-communicate-signals-between-trabecular-meshwork-cells
#19
Kate E Keller, John M Bradley, Ying Ying Sun, Yong-Feng Yang, Ted S Acott
Purpose: The actin cytoskeleton of trabecular meshwork (TM) cells plays a role in regulating aqueous humor outflow. Many studies have investigated stress fibers, but F-actin also assembles into other supramolecular structures including filopodia. Recently, specialized filopodia called tunneling nanotubes (TNTs) have been described, which communicate molecular signals and organelles directly between cells. Here, we investigate TNT formation by TM cells. Methods: Human TM cells were labeled separately with the fluorescent dyes, DiO and DiD, or with mitochondrial dye...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29032399/evidence-of-extracellular-vesicles-biogenesis-and-release-in-mouse-embryonic-stem-cells
#20
Lilian Cruz, Jenny Andrea Arevalo Romero, Mariana Brandão Prado, Tiago G Santos, Marilene Hohmuth Lopes
Extracellular vesicles (EVs) released by mouse embryonic stem cells (mESCs) are considered a source of bioactive molecules that modulate their microenvironment by acting on intercellular communication. Either intracellular endosomal machinery or their derived EVs have been considered a relevant system of signal circuits processing. Herein, we show that these features are found in mESCs. Ultrastructural analysis revealed structures and organelles of the endosomal system such as coated pits and endocytosis-related vesicles, prominent rough endoplasmic reticulum and Golgi apparatus, and multivesicular bodies (MVBs) containing either few or many intraluminal vesicles (ILVs) that could be released as exosomes to extracellular milieu...
October 14, 2017: Stem Cell Reviews
keyword
keyword
102375
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"