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https://www.readbyqxmd.com/read/24269342/ranolazine-in-the-prevention-of-anthracycline-cardiotoxicity
#1
REVIEW
Francesco Corradi, Luca Paolini, Raffaele De Caterina
Ranolazine is a selective inhibitor of the cardiomyocyte late inward sodium current, INaL, and features anti-ischemic, antiarrhythmic and ATP-sparing actions. Extensive laboratory data show that anthracyclines can induce the production of reactive oxygen species (ROS). Other laboratory data show that ROS can hyperactivate the cardiac isoform of calmodulin-dependent protein kinase II (CaMKII δ), in turn inducing a hyperactivation of the cardiac late sodium current (INaL) and a resulting cytosolic calcium overload...
January 2014: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/24118178/update-on-treatment-options-for-spinal-brucellosis
#2
MULTICENTER STUDY
A Ulu-Kilic, A Karakas, H Erdem, T Turker, A S Inal, O Ak, H Turan, E Kazak, A Inan, F Duygu, H Demiraslan, C Kader, A Sener, S Dayan, O Deveci, R Tekin, N Saltoglu, M Aydın, E S Horasan, H C Gul, B Ceylan, A Kadanalı, O Karabay, G Karagoz, U Kayabas, V Turhan, D Engin, S Gulsun, N Elaldı, S Alabay
We evaluated the efficacy and tolerability of antibiotic regimens and optimal duration of therapy in complicated and uncomplicated forms of spinal brucellosis. This is a multicentre, retrospective and comparative study involving a total of 293 patients with spinal brucellosis from 19 health institutions. Comparison of complicated and uncomplicated spinal brucellosis was statistically analysed. Complicated spinal brucellosis was diagnosed in 78 (26.6%) of our patients. Clinical presentation was found to be significantly more acute, with fever and weight loss, in patients in the complicated group...
February 2014: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/22155822/efficacy-and-tolerability-of-antibiotic-combinations-in-neurobrucellosis-results-of-the-istanbul-study
#3
MULTICENTER STUDY
Hakan Erdem, Aysegül Ulu-Kilic, Selim Kilic, Mustafa Karahocagil, Ghaydaa Shehata, Necla Eren-Tulek, Funda Yetkin, Mustafa Kemal Celen, Nurgul Ceran, Hanefi Cem Gul, Gurkan Mert, Suda Tekin-Koruk, Murat Dizbay, Ayse Seza Inal, Saygin Nayman-Alpat, Mile Bosilkovski, Dilara Inan, Nese Saltoglu, Laila Abdel-Baky, Maria Teresa Adeva-Bartolome, Bahadir Ceylan, Suzan Sacar, Vedat Turhan, Emel Yilmaz, Nazif Elaldi, Zeliha Kocak-Tufan, Kenan Ugurlu, Basak Dokuzoguz, Hava Yilmaz, Sibel Gundes, Rahmet Guner, Nail Ozgunes, Asim Ulcay, Serhat Unal, Saim Dayan, Levent Gorenek, Ahmet Karakas, Yesim Tasova, Gaye Usluer, Yasar Bayindir, Behice Kurtaran, Oguz Resat Sipahi, Hakan Leblebicioglu
No data on whether brucellar meningitis or meningoencephalitis can be treated with oral antibiotics or whether an intravenous extended-spectrum cephalosporin, namely, ceftriaxone, which does not accumulate in phagocytes, should be added to the regimen exist in the literature. The aim of a study conducted in Istanbul, Turkey, was to compare the efficacy and tolerability of ceftriaxone-based antibiotic treatment regimens with those of an oral treatment protocol in patients with these conditions. This retrospective study enrolled 215 adult patients in 28 health care institutions from four different countries...
March 2012: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/20424552/antibiotic-resistance-in-community-acquired-urinary-tract-infections-prevalence-and-risk-factors
#4
Behice Kurtaran, Aslihan Candevir, Yesim Tasova, Filiz Kibar, Ayse Seza Inal, Suheyla Komur, Hasan Salih Zeki Aksu
BACKGROUND: This study aimed to identify the agents causing community-acquired urinary tract infections (CAUTIs) and their resistance patterns and to investigate risk factors for ESBL production. MATERIAL/METHODS: Patients diagnosed at the Department of Infectious Diseases in the Cukurova University School of Medicine Hospital with CAUTI between January 2006 and April 2007 were included prospectively. Patient data were recorded and the microorganisms and their sensitivity patterns were evaluated by the university's central microbiology laboratory...
May 2010: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/20006172/intractable-bimaxillary-osteomyelitis-in-osteopetrosis-review-of-the-literature-and-current-therapy
#5
REVIEW
Melahat Oğütcen-Toller, Mustafa Tek, Ismail Sener, Cihan Bereket, Samet Inal, Bora Ozden
PURPOSE: Osteopetrosis (OP), also known as Albers-Schönberg disease, is a rare metabolic bone disease caused by a congenital defect in the development or function of the osteoclasts resulting in generalized increase in skeletal mass. Osteomyelitis is a recognized complication, and prevention of dental infections can be difficult. The locations of osteomyelitis in the jawbones have been either in the mandible or maxilla. In this article, a case of OP complicated with osteomyelitis of the mandible and the maxilla is presented, and types of OP and treatment options are discussed with a literature review...
January 2010: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/18651549/efficacy-of-deferoxamine-n-acetylcysteine-and-selenium-treatments-in-rats-with-adriamycin-induced-nephrotic-syndrome
#6
COMPARATIVE STUDY
F Bulucu, C Oktenli, L Kenar, R Ocal, B Koc, V Inal, L Yamanel, H Yaman, Y S Sanisoglu, A Aydin
BACKGROUND: Various experimental models related to Adriamycin (ADR)-induced nephropathy have been reported. The purpose of the present study was to evaluate the efficacy of N-acetylcysteine (NAC), deferoxamine (DFO) and selenium in protection against renal injury in ADR nephropathy. METHODS: The study included 53 Sprague Dawley male rats. Nephrotic syndrome was induced by injection of ADR 5 mg/kg intravenously (n=46). Control rats (n=7) were injected with an equal volume of isotonic saline...
July 2008: Journal of Nephrology
https://www.readbyqxmd.com/read/16718277/effects-of-antibacterial-therapy-on-psa-change-in-the-presence-and-absence-of-prostatic-inflammation-in-patients-with-psa-levels-between-4-and-10-ng-ml
#7
COMPARATIVE STUDY
O Kaygisiz, O Uğurlu, M Koşan, G Inal, B Oztürk, M Cetinkaya
We investigated the effect of prostatic inflammation on prostate-specific antigen (PSA) and per cent-free PSA levels changing after antibacterial therapy. We evaluated 48 patients whose PSA levels were between 4 and 10 ng/ml, without any suspicious findings on digital rectal examination, with no infection findings in urine analysis. Prostatic inflammation was assessed with prostatic massage. All the patients were given antibiotic therapy for 3 weeks. Patients were re-evaluated 3 weeks after antibacterial therapy with PSA (free/total) and urinalysis...
2006: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/15494811/investigation-of-the-antibiotic-susceptibility-patterns-of-pathogens-causing-nosocomial-infections
#8
COMPARATIVE STUDY
Akgun Yaman, Yesim Tasova, Filiz Kibar, Ayse S Inal, Nese Saltoglu, Ozlem Buyukcelik, Behice Kurtaran, Ismail H Dundar
OBJECTIVE: The aim of this study is to determine the resistance patterns of bacteria causing nosocomial infections. The outcome of this resistance was followed for 3 years. METHODS: This study was carried out during 2000 to 2002 at a university hospital in Turkey. The resistance patterns of 570 bacteria (390 Gram-negative, 180 Gram-positive) against meropenem, imipenem, ceftazidime, cefotaxime, cefepime, piperacillin/tazobactam, ciprofloxacin and tobramycin were investigated using the E-test...
October 2004: Saudi Medical Journal
https://www.readbyqxmd.com/read/12956433/phage-therapy-a-reappraisal-of-bacteriophages-as-antibiotics
#9
REVIEW
Jameel M Inal
The concept of phage therapy to treat bacterial infections was born with the discovery of the bacteriophage almost a century ago. After a chequered history, its current renaissance is fueled by the dangerous appearance of antibiotic-resistant bacteria on a global scale. As a mark of this renewed interest, the unanswered problems of phage therapy are now being addressed, especially for human use. Phage therapy in the agricultural, food-processing and fishery industries is already being successfully applied, and this review, whilst being aware of the potential drawbacks, emphasizes the need for further carefully controlled empirical data on its efficacy and safety in treating human and animal disease, especially in view of its numerous advantages over antibiotics...
2003: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/8689515/fournier-s-disease-adjunctive-hyperbaric-oxygen-therapy-to-classic-therapy
#10
K Baykal, S Albayrak, H Inal, E Elbuken, K Dündar, Y Onol
Fournier's disease is a very rare and highly fatal necrotizing fasciitis of genital and perineal tissues. Conventional treatment of Fournier's disease includes surgical debridement and antibiotic therapy. We describe a case of Fournier's disease where we added hyperbaric oxygen therapy to the conventional treatment regimen.
March 1996: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/3297746/antibiotic-sensitivity-and-mutation-rates-to-antibiotic-resistance-in-mycoplasma-mycoides-ssp-mycoides
#11
D H Lee, R J Miles, J R Inal
The antibiotic resistance of Mycoplasma mycoides ssp. mycoides strain T1 was investigated. This strain was resistant to high levels (greater than 100 micrograms ml-1) of rifampicin and nalidixic acid. It was sensitive to streptomycin, spectinomycin and novobiocin; however, single step mutants with high levels of resistance (greater than 100 micrograms ml-1) were readily isolated. With erythromycin and tylosin for which the minimum inhibitory concentration (MIC) for the parent strain was less than 0.1 microgram ml-1, mutants resistant to greater than 100 micrograms ml-1 were obtained in two and three steps respectively...
June 1987: Epidemiology and Infection
https://www.readbyqxmd.com/read/1163168/-official-inquiry-into-the-presence-of-salmonella-in-frozen-slaughtered-poultry-on-the-german-market-author-s-transl
#12
COMPARATIVE STUDY
H Siems, G Hildebrandt, T Inal, H J Sinell
Between the period of August 1973 and May 1974, 553 roasting chickens, soup chickens, ducks, and geese from seven different countries were examined for the presence of Salmonella. In 284 (= 51,4%) specimens 23 various Salmonella serotypes were discovered. Out of 475 Salmonella isolates 244 (= 51,4%) were resistant to streptomycin, the sulfonamide complex or their combination whereas 195 (= 41,0%) were sensitive to all eight tested antibiotics. Of greater importance for nutritive and therapeutic application of antibiotics is, however, the resistance of 36 (= 7,6%) Salmonella strains to tetracyclines, ampicillin and kanamycin, 28 (= 5,9%) of the salmonellae showing resistance exclusively to tetracyclines...
1975: Zentralblatt Für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe B: Hygiene, Präventive Medizin
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