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Bioactive glass

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https://www.readbyqxmd.com/read/28737023/monodispersed-bioactive-glass-nanoclusters-with-ultralarge-pores-and-intrinsic-exceptionally-high-mirna-loading-for-efficiently-enhancing-bone-regeneration
#1
Yumeng Xue, Yi Guo, Meng Yu, Min Wang, Peter X Ma, Bo Lei
Bioactive glass nanoparticles (BGNs) have attracted much attention in drug delivery and bone tissue regeneration, due to the advantages including biodegradation, high bone-bonding bioactivity, and facile large-scale fabrication. However, the wide biomedical applications of BGNs such as efficient gene delivery are limited due to their poor pore structure and easy aggregation. Herein, for the first time, this study reports novel monodispersed bioactive glass nanoclusters (BGNCs) with ultralarge mesopores (10-30 nm) and excellent miRNA delivery for accelerating critical-sized bone regeneration...
July 24, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28735029/peptide-modification-of-polyimide-insulated-microwires-towards-improved-biocompatibility-through-reduced-glial-scarring
#2
Sangita Sridar, Matthew A Churchward, Vivian K Mushahwar, Kathryn G Todd, Anastasia L Elias
The goal of this study is to improve the integration of implanted microdevices with tissue in the central nervous system (CNS). The long-term utility of neuroprosthetic devices implanted in the CNS is affected by the formation of a scar by resident glial cells (astrocytes and microglia), limiting the viability and functional stability of the devices. Reduction in the proliferation of glial cells is expected to enhance the biocompatibility of devices. We demonstrate the modification of polyimide-insulated microelectrodes with a bioactive peptide KHIFSDDSSE...
July 19, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28729613/effects-of-sintering-temperature-on-crystallization-and-fabrication-of-porous-bioactive-glass-scaffolds-for-bone-regeneration
#3
E P Erasmus, O T Johnson, I Sigalas, J Massera
In this work the sintering ability of borosilicate (S53B50), borophosphate (P40B10) and phosphate (Sr) bioactive glasses was investigated. The glass powders were crushed and sintered in air at a heating rate of 10 °C/min for 2 hours at sintering temperatures between 480 °C-600 °C. The aim was to define the optimum sintering temperature prior to glass crystallization. The density of the samples was found to decrease when the temperature was increased up to 580 °C; probably due to the inhibition of the viscous flow of the particles during sintering thereby reducing the densification of the material...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28720333/bioactivity-and-properties-of-a-dental-adhesive-functionalized-with-polyhedral-oligomeric-silsesquioxanes-poss-and-bioactive-glass
#4
Marta Rizk, Lisa Hohlfeld, Loan Tao Thanh, Ralf Biehl, Nicole Lühmann, Dirk Mohn, Annette Wiegand
OBJECTIVES: This study aimed to analyze the effect of infiltrating a commercial adhesive with nanosized bioactive glass (BG-Bi) particles or methacryl-functionalized polyhedral oligomeric silsesquioxanes (POSS) on material properties and bioactivity. METHODS: An acetone-based dental adhesive (Solobond Plus adhesive, VOCO GmbH, Cuxhaven, Germany) was infiltrated with nanosized bioactive glass particles (0.1 or 1wt%), or with monofunctional or multifunctional POSS particles (10 or 20wt%)...
July 15, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28713017/intracellular-co-delivery-of-sr-ion-and-phenamil-drug-through-mesoporous-bioglass-nanocarriers-synergizes-bmp-signaling-and-tissue-mineralization
#5
Jung-Hwan Lee, Nandin Mandakhbayar, Ahmed El-Fiqi, Haw-Won Kim
Inducing differentiation and maturation of resident multipotent stem cells (MSCs) is an important strategy to regenerate hard tissues in mal-calcification conditions. Here we explore a co-delivery approach of therapeutic molecules comprised of ion and drug through a mesoporous bioglass nanoparticle (MBN) for this purpose. Recently, MBN has offered unique potential as a nanocarrier for hard tissues, in terms of high mesoporosity, bone bioactivity (and possibly degradability), tunable delivery of biomolecules, and ionic modification...
July 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28709036/hydroxyapatite-and-bioactive-glass-surfaces-for-fiber-reinforced-composite-implants-via-surface-ablation-by-excimer-laser
#6
Julia Kulkova, Niko Moritz, Hannu Huhtinen, Riina Mattila, Ivan Donati, Eleonora Marsich, Sergio Paoletti, Pekka K Vallittu
In skeletal reconstructions, composites, such as bisphenol-A-glycidyldimethacrylate resin reinforced with glass fibers, are potentially useful alternatives to metallic implants. Recently, we reported a novel method to prepare bioactive surfaces for these composites. Surface etching by Excimer laser was used to expose bioactive glass granules embedded in the resin. The purpose of this study was to analyze two types of bioactive surfaces created by this technique. The surfaces contained bioactive glass and hydroxyapatite granules...
July 4, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28697772/injectable-and-compression-resistant-low-viscosity-polymer-ceramic-composite-carriers-for-rhbmp-2-in-a-rabbit-model-of-posterolateral-fusion-a-pilot-study
#7
Stefanie M Shiels, Anne D Talley, Madison A P McGough, Katarzyna J Zienkiewicz, Kerem Kalpakci, Daniel Shimko, Scott A Guelcher, Joseph C Wenke
BACKGROUND: The challenging biological and mechanical environment of posterolateral fusion (PLF) requires a carrier that spans the transverse processes and resists the compressive forces of the posterior musculature. The less traumatic posterolateral approach enabled by minimally invasive surgical techniques has prompted investigations into alternative rhBMP-2 carriers that are injectable, settable, and compression-resistant. In this pilot study, we investigated injectable low-viscosity (LV) polymer/composite bone grafts as compression-resistant carriers for rhBMP-2 in a single-level rabbit PLF model...
July 11, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28684335/structural-and-physico-chemical-analysis-of-calcium-strontium-substituted-near-invert-phosphate-based-glasses-for-biomedical-applications
#8
U Patel, R M Moss, K M Z Hossain, A R Kennedy, E R Barney, I Ahmed, A C Hannon
Neutron diffraction, (23)Na and (31)P NMR and FTIR spectroscopy have been used to investigate the structural effects of substituting CaO with SrO in a 40P2O5·(16-x)CaO·20Na2O·24MgO·xSrO glass, where x is 0, 4, 8, 12 and 16 mol%. The (31)P solid-state NMR results showed similar amounts of Q(1) and Q(2) units for all of the multicomponent glasses investigated, showing that the substitution of Sr for Ca has no effect on the phosphate network. The M-O coordinations (M= Mg, Ca, Sr, Na) were determined for binary alkali and alkaline earth metaphosphates using neutron diffraction and broad asymmetric distributions of bond length were observed, with coordination numbers that were smaller and bond lengths that were shorter than in corresponding crystals...
July 3, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28676434/multifunctional-bioactive-glass-and-glass-ceramic-biomaterials-with-antibacterial-properties-for-repair-and-regeneration-of-bone-tissue
#9
REVIEW
João S Fernandes, Piergiorgio Gentile, Ricardo A Pires, Rui L Reis, Paul V Hatton
Bioactive glasses (BGs) and related glass-ceramic biomaterials have been used in bone tissue repair for over 30years. Previous work in this field was comprehensively reviewed including by their inventor Larry Hench, and the key features and properties of BGs are well understood. More recently, attention has focused on their modification to further enhance the osteogenic behaviour, or further compositional changes that may introduce additional properties, such as antimicrobial activity. Evidence is emerging that BGs and related glass-ceramics may be modified in such a way as to simultaneously introduce more than one desirable property...
July 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28675029/binary-doping-of-strontium-and-copper-enhancing-osteogenesis-and-angiogenesis-of-bioactive-glass-nanofibers-while-suppressing-osteoclast-activity
#10
Lin Weng, Sunil Kumar Boda, Matthew J Teusink, Franklin D Shuler, Xiaoran Li, Jingwei Xie
Electrospun bioactive glass fibers show great potential as scaffolds for bone tissue engineering due to their architectural biomimicry of the bone extracellular matrix and their composition capable of providing soluble bioactive cues for bone regeneration and remodeling. Trace elements can be doped to further promote osteogenesis and angiogenesis during bone regeneration. Cationic substitution of strontium for calcium in bioactive glass positively enhances osteoblast phenotype, while suppressing osteoclast activity...
July 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28664737/correction-to-evidence-of-catalase-mimetic-activity-in-ce-3-ce-4-doped-bioactive-glasses
#11
Valentina Nicolini, Elisa Gambuzzi, Gianluca Malavasi, Ledi Menabue, Maria Cristina Menziani, Gigliola Lusvardi, Alfonso Pedone, Francesco Benedetti, Paola Luches, Sergio D'Addato, Sergio Valeri
No abstract text is available yet for this article.
June 30, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28663772/proton-environments-in-biomimetic-calcium-phosphates-formed-from-mesoporous-bioactive-cao-sio2-p2o5-glasses-in-vitro-insights-from-solid-state-nmr
#12
Renny Mathew, Claudia Turdean-Ionescu, Yang Yu, Baltzar Stevensson, Isabel Izquierdo-Barba, Ana García, Daniel Arcos, María Vallet-Regí, Mattias Edén
When exposed to body fluids, mesoporous bioactive glasses (MBGs) of the CaO-SiO2-P2O5 system develop a bone-bonding surface layer that initially consists of amorphous calcium phosphate (ACP), which transforms into hydroxy-carbonate apatite (HCA) with a very similar composition as bone/dentin mineral. Information from various (1)H-based solid-state nuclear magnetic resonance (NMR) experiments was combined to elucidate the evolution of the proton speciations both at the MBG surface and within each ACP/HCA constituent of the biomimetic phosphate layer formed when each of three MBGs with distinct Ca, Si, and P contents was immersed in a simulated body fluid (SBF) for variable periods between 15 min and 30 days...
June 22, 2017: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
https://www.readbyqxmd.com/read/28643515/structures-of-degradation-products-and-degradation-pathways-of-aflatoxin-b1-by-high-voltage-atmospheric-cold-plasma-hvacp-treatment
#13
Hu Shi, Bruce Cooper, Richard L Stroshine, Klein E Ileleji, Kevin M Keener
High-voltage atmospheric cold plasma (HVACP) is a novel nonthermal decontamination technology that has potential for use in the food industry. In this study, HVACP was applied to treat pure aflatoxin B1 (AFB1) powder on a glass slide. AFB1 was degraded by 76% using a 5 min HVACP treatment in air having 40% relative humidity. The degradation products of AFB1 were separated, and their molecular formulas were elucidated using liquid-chromatography time-of-flight mass spectrometry (HPLC-TOF-MS). Six main degradation products were observed...
July 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28642057/novel-multifunctional-dental-cement-to-prevent-enamel-demineralization-near-orthodontic-brackets
#14
Yansong Ma, Ning Zhang, Michael D Weir, Yuxing Bai, Hockin H K Xu
OBJECTIVES: White spot lesions due to biofilm acid-induced enamel demineralization are prevalent in orthodontic treatments. The aim of this study was to develop a novel bioactive multifunctional cement with protein-repellent, antibacterial and remineralizing capabilities, and investigate the effects on enamel hardness and lesion depth in vitro for the first time. MATERIALS AND METHODS: 2-Methacryloyloxyethyl phosphorylcholine (MPC), dimethylaminohexadecyl methacrylate (DMAHDM), and nanoparticles of amorphous calcium phosphate (NACP) were incorporated into a resin-modified glass ionomer (RMGI)...
June 19, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28629020/a-comparative-in-vivo-evaluation-of-bioactive-glasses-and-bioactive-glass-based-composites-for-bone-tissue-repair
#15
Devis Bellucci, Alexandre Anesi, Roberta Salvatori, Luigi Chiarini, Valeria Cannillo
In this work a set of novel materials for bone tissue regeneration have been tested in vivo in an animal model. In fact, despite many studies have been devoted to amorphous 45S5 Bioglass®, there is lack in the literature of works aimed to study the in vivo performance of heat-treated - and thus partially crystallized - 45S5. As widely reported, crystallization limits the bioactivity of 45S5 and is the main reason that prevents a broader use of this material. Thus, in the present work, a recently developed bioactive glass (BG_Ca/Mix) is tested, since previous investigations demonstrated that BG_Ca/Mix is particularly promising by virtue of both its high bioactivity and lower tendency to crystallize with respect to 45S5...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28624656/strontium-and-cobalt-substituted-bioactive-glasses-seeded-with-human-umbilical-cord-perivascular-cells-to-promote-bone-regeneration-via-enhanced-osteogenic-and-angiogenic-activities
#16
Saeid Kargozar, Nasrin Lotfibakhshaiesh, Jafar Ai, Masoud Mozafari, Peiman Brouki Milan, Sepideh Hamzehlou, Mahmood Barati, Francesco Baino, Robert G Hill, Mohammad Taghi Joghataei
Designing and developing new biomaterials to accelerate bone healing are currently under progress. In this study, we attempted to promote osteogenesis using strontium- and cobalt-substituted bioactive glasses (BGs) seeded with human umbilical cord perivascular cells (HUCPVCs) in a critical size defect in the distal femur of rabbit animal model. The BG particles were successfully synthesized in the form of granules using the melt-derived route. After being isolated, HUCPVCs were expanded and then characterized to use during in vitro and in vivo procedures...
June 15, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28622750/preparation-and-in%C3%A2-vivo-evaluation-of-a-silicate-based-composite-bone-cement
#17
Bing Ma, Zhiguang Huan, Chen Xu, Nan Ma, Haibo Zhu, Jipin Zhong, Jiang Chang
Silicate-based cements have been developed as a class of bioactive and biodegradable bone cements owing to their good in vitro bioactivity and ability to dissolve in a simulated body fluid. Until recently, however, the in vivo evidence of their ability to support bone regeneration is still scarce. In the present study, a pilot in vivo evaluation of a silicate-based composite bone cement (CSC) was carried out in a rabbit femur defect model. The cement was composed of tricalcium silicate, 45S5 bioglass and calcium sulfate, and the self-setting properties of the material were established...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28620229/novel-bioactive-glass-based-injectable-bone-cement-with-improved-osteoinductivity-and-its-in-vivo-evaluation
#18
Tengjiao Zhu, Huihui Ren, Ailing Li, Bingchuan Liu, Caiyun Cui, Yanmei Dong, Yun Tian, Dong Qiu
Recently, more and more attention has been paid to the development of a new generation of injectable bone cements that are bioactive, biodegradable and are able to have appropriate mechanical properties for treatment of vertebral compression fractures (VCFs). In this study, a novel PSC/CS composite cement with high content of PSC (a phytic acid-derived bioactive glass) was prepared and evaluated in both vitro and vivo. The PSC/CS cement showed excellent injectability, good resistance to disintegration, radiopacity and suitable mechanical properties...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28618977/sacrificial-template-method-for-the-synthesis-of-three-dimensional-nanofibrous-58s-bioglass-scaffold-and-its-in%C3%A2-vitro-bioactivity-and-cell-responses
#19
Honglin Luo, Yang Zhang, Gen Li, Junpin Tu, Zhiwei Yang, Guangyao Xiong, Zheren Wang, Yuan Huang, Yizao Wan
Three-dimensional nanofibrous scaffolds that morphologically mimic natural extracellular matrices hold great promises in tissue engineering and regenerative medicine due to their increased cell attachment and differentiation compared with block structure. In this work, for the first time, three-dimensional porous nanofibrous 58S bioglass scaffolds have been fabricated using a sacrificial template method. During the process, a natural three-dimensional nanofibrous bacterial cellulose was used as the sacrificial template on which precursor 58S glass was deposited via a sol-gel route...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28615491/enhanced-osteointegration-of-poly-methylmethacrylate-bone-cements-by-incorporating-strontium-containing-borate-bioactive-glass
#20
Xu Cui, Chengcheng Huang, Meng Zhang, Changshun Ruan, Songlin Peng, Li Li, Wenlong Liu, Ting Wang, Bing Li, Wenhai Huang, Mohamed N Rahaman, William W Lu, Haobo Pan
Although poly(methylmethacrylate) (PMMA) cements are widely used in orthopaedics, they have numerous drawbacks. This study aimed to improve their bioactivity and osseointegration by incorporating strontium-containing borate bioactive glass (SrBG) as the reinforcement phase and bioactive filler of PMMA cement. The prepared SrBG/PMMA composite cements showed significantly decreased polymerization temperature when compared with PMMA and retained properties of appropriate setting time and high mechanical strength...
June 2017: Journal of the Royal Society, Interface
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