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Bioactive glass

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https://www.readbyqxmd.com/read/28541125/electrically-conductive-borate-based-bioactive-glass-scaffolds-for-bone-tissue-engineering-applications
#1
Mert Turk, Aylin M Deliormanlı
In this study, electrically conductive, borate-based, porous 13-93B3 bioactive glass composite scaffolds were prepared using a polymer foam replication technique. For this purpose, a slurry containing 40 vol% glass particles and 0-10 wt% graphene nanoplatelets was prepared by dispersing the particles in ethanol in the presence of ethyl cellulose. Composite scaffolds were subjected to a controlled heat treatment, in air atmosphere, to decompose the foam and sinter the glass particles into a dense network...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28538076/regeneration-of-cystic-bone-cavities-and-bone-defects-with-bioactive-glass-s53p4-in-the-upper-and-lower-jaws
#2
Patricia Stoor, Satu Apajalahti, Risto Kontio
Cysts and tumors are common lesions in the jaws. To be able to retain a good volume of the alveolar ridge during healing as well as strengthening the angle and body of the mandible and provide an instant improved support for adjacent teeth, reliable long-term bone regeneration is needed. The purpose of this prospective study was to promote bone regeneration by filling bony defects in the upper or lower jaw with granules of the bioactive glass S53P4 (BAG), which have osteostimulative and antimicrobial properties...
May 19, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28535954/sol-gel-derived-bioactive-glass-nanoparticle-incorporated-glass-ionomer-cement-with-or-without-chitosan-for-enhanced-mechanical-and-biomineralization-properties
#3
Dong-Ae Kim, Jung-Hwan Lee, Soo-Kyung Jun, Hae-Won Kim, Mohamed Eltohamy, Hae-Hyoung Lee
OBJECTIVE: This study investigated the mechanical and in vitro biological properties (in immortalized human dental pulp stem cells (ihDPSCs)) of bioactive glass nanoparticle (BGN)-incorporated glass ionomer cement (GIC) with or without chitosan as a binder. METHODS: After the BGNs were synthesized and characterized, three experimental GICs and a control (conventional GIC) that differed in the additive incorporated into a commercial GIC liquid (Hy-bond, Shofu, Japan) were produced: BG5 (5wt% of BGNs), CL0...
May 20, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28535357/effects-of-composites-containing-bioactive-glasses-on-demineralized-dentin
#4
A Tezvergil-Mutluay, R Seseogullari-Dirihan, V P Feitosa, G Cama, D S Brauer, S Sauro
The aim of this study was to evaluate the degradation of completely demineralized dentin specimens in contact with a filler-free or 2 ion-releasing resins containing micrometer-sized particles of Bioglass 45S5 (BAG) or fluoride-containing phosphate-rich bioactive glass (BAG-F). Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) were also used to evaluate the remineralization induced by the experimental ion-releasing resin-based materials. Dentin beams were totally demineralized in H3PO4 (10%) and placed in direct contact with a filler-free (RESIN) or 2 experimental ion-releasing resins (BAG or BAG-F) and immersed in artificial saliva (AS) up to 30 d...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28532119/poly-d-l-lactide-polycaprolactone-bioactive-glasss-nanocomposites-materials-for-anterior-cruciate-ligament-reconstruction-screws-the-effect-of-glass-surface-functionalization-on-mechanical-properties-and-cell-behaviors
#5
Javad Esmaeilzadeh, Saeed Hesaraki, Seyed Mohammad-Mehdi Hadavi, Mohammad Hosein Ebrahimzadeh, Masoud Esfandeh
In this paper, different nanocomposites made of a polymer blend (80% of PDLLA and 20% of PCL in w/w) and various amounts of a sol-gel derived bioactive glass nanoparticles (0, 1, 3 and 6wt%) were prepared using a solvent-evaporation technique. The morphology, mechanical properties and osteoblastic cell behaviors of the nanocomposites were evaluated. According to the early results, addition of bioactive glass nanoparticles to the polymer matrix reduced the tensile and flexural strength because of a non-uniform distribution of the nanoparticles...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532092/cytocompatibility-studies-of-titania-doped-calcium-borosilicate-bioactive-glasses-in-vitro
#6
Rajkumar Samudrala, Abdul Azeem P, Vasudevarao Penugurti, Bramanandam Manavathi
The present study aims to elucidate the applications of Titania (TiO2) doped calcium borosilicate glass as a biocompatible material in regenerative orthopedic applications. In this context, we have examined the bioactivity of various concentrations of TiO2 doped glasses with the help of simulated body fluid (SBF). Cytocompatibility, cell proliferation, and protein expression studies revealed the potential candidature of TiO2 doped glasses on osteoblast cell lines (MG-63). We hypothesized that TiO2 doped calcium borosilicate glasses are most cytocompatible material for bone implants...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532039/bioactivity-mechanical-properties-and-drug-delivery-ability-of-bioactive-glass-ceramic-scaffolds-coated-with-a-natural-derived-polymer
#7
M Araújo, R Viveiros, A Philippart, M Miola, S Doumett, G Baldi, J Perez, A R Boccaccini, A Aguiar-Ricardo, E Verné
In this work, hybrid melanin-coated bioactive glass-ceramic multifunctional scaffolds were developed and characterized in terms of mechanical strength, in vitro bioactivity in simulated body fluid (SBF) and ability to load ibuprofen. The coated scaffolds exhibited an accelerated bioactivity in comparison with the uncoated ones, being able of developing hydroxyapatite-like crystals after 7days soaking in simulated body fluid (SBF). Besides its positive influence on the scaffolds bioactivity, the melanin coating was able to enhance their mechanical properties, increasing the initial compressive strength by a factor of >2...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28526787/development-of-multi-well-plate-methods-using-pure-cultures-of-methanogens-to-identify-new-inhibitors-for-suppressing-ruminant-methane-emissions
#8
M R Weimar, J Cheung, D Dey, C McSweeney, M Morrison, Y Kobayashi, W B Whitman, V Carbone, L R Schofield, R S Ronimus, G M Cook
Hydrogenotrophic methanogens typically require strictly anaerobic culturing conditions in glass tubes with overpressures of H2 and CO2 that are both time-consuming and costly. To increase the throughput for screening chemical compound libraries, 96-well microtiter plate methods for the growth of a marine (environmental) methanogen Methanococcus maripaludis strain S2 and the rumen methanogen Methanobrevibacter species AbM4 were developed. A number of key parameters (inoculum size, reducing agents for media preparation, duration of assay, inhibitor solvents and culture volume) were optimised to achieve robust and reproducible growth in a high-throughput microtiter plate format...
May 19, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28526091/a-pre-therapeutic-coating-for-medical-devices-that-prevents-the-attachment-of-candida-albicans
#9
Diego Vargas-Blanco, Aung Lynn, Jonah Rosch, Rony Noreldin, Anthony Salerni, Christopher Lambert, Reeta P Rao
BACKGROUND: Hospital acquired fungal infections are defined as "never events"-medical errors that should never have happened. Systemic Candida albicans infections results in 30-50% mortality rates. Typically, adhesion to abiotic medical devices and implants initiates such infections. Efficient adhesion initiates formation of aggressive biofilms that are difficult to treat. Therefore, inhibitors of adhesion are important for drug development and likely to have a broad spectrum efficacy against many fungal pathogens...
May 19, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28498659/modelling-the-onset-of-phase-separation-in-cao-sio2-cacl2-chlorine-containing-silicate-glasses
#10
Laura Ann Swansbury, Gavin Mountjoy, Xiaojing Chen, Natalia Karpukhina, Robert G Hill
The addition of chlorine into a bioactive glass composition is expected to reduce its abrasiveness and increase its bioactivity which is important for dental applications such as toothpastes. There is a lack of information and understanding regarding the structural role of chlorine in chlorine-containing bioactive silicate glasses. This has prompted classical core-shell model molecular dynamics simulations of (50-x/2)CaO-(50-x/2)SiO2-xCaCl2 glasses to be performed, where x ranges from x=0.0 to x=43.1 mol% CaCl2...
May 12, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28496325/multifunctional-and-biomimetic-fish-collagen-bioactive-glass-nanofibers-fabrication-antibacterial-activity-and-inducing-skin-regeneration-in-vitro-and-in-vivo
#11
Tian Zhou, Baiyan Sui, Xiumei Mo, Jiao Sun
The development of skin wound dressings with excellent properties has always been an important challenge in the field of biomedicine. In this study, biomimetic electrospun fish collagen/bioactive glass (Col/BG) nanofibers were prepared. Their structure, tensile strength, antibacterial activity and biological effects on human keratinocytes, human dermal fibroblasts and human vascular endothelial cells were investigated. Furthermore, the Sprague Dawley rat skin defect model was used to validate their effect on wound healing...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28492650/stabilization-of-a-t-zro2-polymorph-in-a-glassy-sio2-matrix-at-elevated-temperatures-accomplished-by-ceria-additions
#12
S Vasanthavel, Brian Derby, S Kannan
Glass-ceramic composites are considered important candidates for load bearing orthopaedic applications owing to their combined salient features of bioactivity and mechanical strength. Herein, we report the impact of ceria (CeO2) additions on the structural and mechanical behaviour of ZrO2-SiO2 binary oxides as a glass-ceramic composite for hard tissue replacements. A wide range of ceria additions to the ZrO2-SiO2 system have been performed via sol-gel synthesis. The structural behaviour of the synthesized compositions is investigated at elevated temperatures using a combination of XRD, Raman spectroscopy, TEM and SEM...
May 11, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28488867/experimental-and-theoretical-investigation-of-the-structural-role-of-titanium-oxide-in-cao-p2o5-tio2-invert-glass
#13
Hirotaka Maeda, Tomoyuki Tamura, Toshihiro Kasuga
Understanding the structural role of TiO2 in calcium phosphate invert glasses is key for developing a new glass design for biomedical applications. Experimental and computational analysis methods were used to investigate the impact of TiO2 substitution in these glasses. Spectroscopic analyses indicated that titanium oxide exists as both TiO4 and TiO6 units, leading to the formation of Ti-O-P bonds, in spite of depolymerization of the phosphate chains. Classical molecular dynamics showed that the presence of TiO2 influences the phosphate units and CaO polyhedral structures...
May 10, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28483701/prevention-of-bacterial-adhesion-to-zwitterionic-biocompatible-mesoporous-glasses
#14
S Sánchez-Salcedo, A García, María Vallet-Regí
Novel materials, based on Mesoporous Bioactive Glasses (MBGs) in the ternary system SiO2-CaO-P2O5, decorated with (3-aminopropyl)triethoxysilane (APTES) and subsequently with amino acid Lysine (Lys), by post-grafting method on the external surface of the glasses (named MBG-NH2 and MBG-Lys), are reported. The surface functionalization with organic groups did not damage the mesoporous network and their structural and textural properties were also preserved despite the high solubility of MBG matrices. The incorporation of Lys confers a zwitterionic nature to these MBG materials due to the presence of adjacent amine and carboxylic groups in the external surface...
May 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28482587/novel-bioactive-glass-aunp-composites-for-biomedical-applications
#15
K Magyari, T Nagy-Simon, A Vulpoi, R A Popescu, E Licarete, R Stefan, K Hernádi, I Papuc, L Baia
The bioactive glasses doped with gold nanoparticles (AuNPs) are very attractive materials due to their potential in medical applications. In the present study Pluronic-nanogold hybrid nanoparticles were introduced during the sol-gel route of the SiO2-CaO-P2O5 glasses preparation. The obtained samples were characterized by UV-vis spectroscopy, X-ray diffraction, FT-IR spectroscopy, transmission electron and scanning electron microscopy and afterwards they were investigated in terms of bioactivity, protein adsorption and cells viability...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28482522/bioactive-gel-glasses-with-distinctly-different-compositions-bioactivity-viability-of-stem-cells-and-antibiofilm-effect-against-streptococcus-mutans
#16
Renato L Siqueira, Natasha Maurmann, Daniela Burguêz, Daniela P Pereira, Alessandra N S Rastelli, Oscar Peitl, Patricia Pranke, Edgar D Zanotto
In this study, an evaluation was performed to determine the in vitro bioactivity, viability of stem cells, and antibiofilm effect against Streptococcus mutans of two bioactive gel-glass 60SiO2-36CaO-4P2O5 (BG-A) and 80SiO2-15CaO-5P2O5 (BG-B) compositions. Both materials were bioactive and undergo the formation of hydroxycarbonate apatite (HCA) on their surfaces when immersed in simulated body fluid (SBF) after 12h, but the BG-A composition showed a more significant formation rate. The pH variation of the samples during the test in SBF indicated that an abrupt change had occurred for the BG-A composition within the first few hours, and the pH was subsequently maintained over time, supporting its stronger antibacterial effects against S...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28482521/development-of-a-bioactive-glass-polymer-composite-for-wound-healing-applications
#17
D Moura, M T Souza, L Liverani, G Rella, G M Luz, J F Mano, A R Boccaccini
This study reports the production and characterization of a composite material for wound healing applications. A bioactive glass obtained by sol-gel process and doped with two different metal ions was investigated. Silver (Ag) and cobalt (Co) were chosen due to their antibacterial and angiogenic properties, respectively, very beneficial in the wound healing process. Poly(ε-caprolactone) (PCL) fibers were produced by electrospinning (ES) from a polymeric solution using acetone as a solvent. After optimization of the ES parameters, two main suspensions were prepared, namely: PCL containing bioactive glass nanoparticles (BG-NP) and PCL with Ag2O and CoO doped BG-NP (DP BG-NP), which were processed with different concentrations of BG-NP (0...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28482504/bioactive-glass-for-dentin-remineralization-a-systematic-review
#18
REVIEW
Delihta Fernando, Nina Attik, Nelly Pradelle-Plasse, Phil Jackson, Brigitte Grosgogeat, Pierre Colon
BACKGROUND AND OBJECTIVES: Strategies to achieve dentin remineralization is at present an important target of restorative dentistry. Remineralization of dentin by a bioactive material is complete only when the tissue regains its functionality. This is achieved when there is adequate apatite formation which most importantly translates into improved mechanical properties of dentin as a result of intrafibrillar mineralization. Bioactive glass (BAG) is a well-known implant material for bone regeneration and is proven to have excellent ability of apatite formation...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28465066/bacterial-adhesion-not-inhibited-by-ion-releasing-bioactive-glass-filler
#19
Kumiko Yoshihara, Noriyuki Nagaoka, Yukinori Maruo, Hidehiko Sano, Yasuhiro Yoshida, Bart Van Meerbeek
OBJECTIVE: Bioactive glasses and surface pre-reacted glass-ionomer (sPRG) filler possess cariostatic properties owing to ion release. Many studies investigated potential cariostatic effects; few studies evaluated the surface stability and the structural changes their surfaces undergo in acidic conditions. METHODS: The surface resistance against acid attack and the surface receptiveness for bacterial adhesion and biofilm formation of a sPRG-filled (Beautifil ll, Shofu) and conventional glass-filled (Herculite XRV Ultra, Kerr) resin-based composite (RBC), and a conventional glass-ionomer cement (GIC; Fuji IX GP Extra, GC) were examined...
April 29, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28457960/highly-degradable-porous-melt-derived-bioactive-glass-foam-scaffolds-for-bone-regeneration
#20
Amy Nommeots-Nomm, Sheyda Labbaf, Aine Devlin, Naomi Todd, Hua Geng, Anu K Solanki, Hok Man Tang, Polytimi Perdika, Alessandra Pinna, Fatemeh Ejeian, Olga Tsigkou, Peter D Lee, Mohammad Hossein Nasr Esfahani, Christopher A Mitchell, Julian R Jones
A challenge in using bioactive melt-derived glass in bone regeneration is to produce scaffolds with interconnected pores while maintaining the amorphous nature of the glass and its associated bioactivity. Here we introduce a method for creating porous melt-derived bioactive glass foam scaffolds with low silica content and report in vitro and preliminary in vivo data. The gel-cast foaming process was adapted, employing temperature controlled gelation of gelatin, rather than the in situ acrylic polymerisation used previously...
April 27, 2017: Acta Biomaterialia
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