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Bioactive glass

Elisa Fiume, Jacopo Barberi, Enrica Verné, Francesco Baino
Nowadays, bioactive glasses (BGs) are mainly used to improve and support the healing process of osseous defects deriving from traumatic events, tumor removal, congenital pathologies, implant revisions, or infections. In the past, several approaches have been proposed in the replacement of extensive bone defects, each one with its own advantages and drawbacks. As a result, the need for synthetic bone grafts is still a remarkable clinical challenge since more than 1 million bone-graft surgical operations are annually performed worldwide...
March 16, 2018: Journal of Functional Biomaterials
María Vallet-Regi, Antonio J Salinas
In 2005, our group described for the first time the structural characterization at the atomic scale of bioactive glasses and the influence of the glasses' nanostructure in their reactivity in simulated body fluids. In that study, two bioactive sol-gel glasses with composition 80%SiO₂-20%CaO and 80%SiO₂-17%CaO-3%P₂O₅ (in mol-%) were characterized by High-Resolution Transmission Electron Microscopy (HRTEM). Such characterization revealed unknown features of the glasses' structure at the local scale that allowed the understanding of their different in vitro behaviors as a consequence of the presence or absence of P₂O₅...
March 11, 2018: Materials
Sergio Allegrini, Antonio Carlos da Silva, Maristela Tsujita, Marcos Barbosa Salles, Sergio Alexandre Gerhke, Francisco José Correa Braga
Synthetic biomaterials submitted to new structural technologies have become ideal for the recovery of traumatized bone tissues and some bone substitutes such as bioactive glass, β-Tricalcium phosphate (β-TCP) and amorphous calcium phosphate (ACP) are being used in areas of tissue defects. For this study, ACP was produced in the form of fibers and then submitted to cytotoxicity testing. A sample of ACP was inserted into the mandibular region of a patient with a lost implant so after removal and curettage, the remaining bone site was filled with the ACP biomaterial...
March 13, 2018: Microscopy Research and Technique
Samir Sorour Sorour, Nasser Nagieb Mohamed, Magdy M Abdel Fattah, Mohammad El-Sayed Abd Elbary, Mohammad Waheed El-Anwar
BACKGROUND: Canal wall down (CWD) mastoidectomy has many drawbacks including chronic otorrhea, granulations, dizziness on exposure to cold or hot water and tendency of debris accumulation in the mastoid cavity demanding periodic cleaning. Many of these problems can be solved by reconstruction of the posterior meatal wall (PMW). OBJECTIVES: To assess the results of PMW reconstruction after CWD mastoidectomy for cholesteatoma using bioactive glass (BAG) that is fabricated and built up intraoperatively...
March 6, 2018: American Journal of Otolaryngology
Praveen Jha, Satwinder Singh Danewalia, Gaurav Sharma, K Singh
Glasses with composition 55SiO2 -10K2 O-(35-x)CaO-xMgO (x = 5, 10, 15 up to 35) were prepared via conventional melt-quench technique. The glasses were converted to glass-ceramics by controlled heat-treatment at 850 °C. Higher content of MgO instead of CaO prevents the devitrification of the glasses. The in-vitro bioactivity of the glasses/glass-ceramics was evaluated in simulated body fluid (SBF). Glasses exhibited better bioactivity than the glass-ceramics. The weight loss and ions leaching profiles (especially potassium ions) of the samples played crucial role in formation of hydroxyapatite layer and its morphology...
May 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Sara Shahbazi, Ali Zamanian, Mohammad Pazouki, Yaser Jafari
A new total biomimetic technique based on both the water uptake and degradation processes is introduced in this study to provide an interesting procedure to fabricate a bioactive and biodegradable synthetic scaffold, which has a good mechanical and structural properties. The optimization of effective parameters to scaffold fabrication was done by response surface methodology/central composite design (CCD). With this method, a synthetic scaffold was fabricated which has a uniform and open-interconnected porous structure with the largest pore size of 100-200μm...
May 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Baltzar Stevensson, Yang Yu, Mattias Edén
We present a comprehensive molecular dynamics (MD) simulation study of composition-structure trends in a set of 25 glasses of widely spanning compositions from the following four systems of increasing complexity: Na2 O-B2 O3 , Na2 O-B2 O3 -SiO2 , Na2 O-CaO-SiO2 -P2 O5 , and Na2 O-CaO-B2 O3 -SiO2 -P2 O5 . The simulations involved new B-O and P-O potential parameters developed within the polarizable shell-model framework, thereby combining the beneficial features of an overall high accuracy and excellent transferability among different glass systems and compositions: this was confirmed by the good accordance with experimental data on the relative BO3 /BO4 populations in borate and boro(phospho)silicate networks, as well as with the orthophosphate fractions in bioactive (boro)phosphosilicate glasses, which is believed to strongly influence their bone-bonding properties...
March 9, 2018: Physical Chemistry Chemical Physics: PCCP
Monica Bortolin, Carlo L Romanò, Alessandro Bidossi, Elena De Vecchi, Roberto Mattina, Lorenzo Drago
AIM: To evaluate the suitability of bioactive glass (BAG)-S53P4 as a bone-graft extender for large bony defect filling in bone and joint infection. MATERIALS & METHODS: Antimicrobial activity of BAG-S53P4 against clinically relevant strains isolated from bone and joint infections was evaluated by means of time-kill curves in presence of bone graft. Furthermore, the susceptibility to BAG of strains resistant to vancomycin and gentamicin was assessed. RESULTS: Though attenuated, BAG maintains a good in vitro antimicrobial activity in presence of human body fluids and tissues contained in bone graft, with the exception of Enterococcus faecalis...
March 9, 2018: Future Microbiology
Lucas Hidalgo Pitaluga, Marina Trevelin Souza, Edgar Dutra Zanotto, Martin Eduardo Santocildes Romero, Paul V Hatton
Barrier membranes that are used for guided tissue regeneration (GTR) therapy usually lack bioactivity and the capability to promote new bone tissue formation. However, the incorporation of an osteogenic agent into polymeric membranes seems to be the most assertive strategy to enhance their regenerative potential. Here, the manufacturing of composite electrospun membranes made of poly (ε-caprolactone) (PCL) and particles of a novel bioactive glass composition (F18) is described. The membranes were mechanically and biologically tested with tensile strength tests and tissue culture with MG-63 osteoblast-like cell line, respectively...
March 8, 2018: Materials
W F Vieira-Junior, L N Ferraz, Nip Pini, Gmb Ambrosano, Fhb Aguiar, Cpm Tabchoury, Danl Lima
AIM: To investigate the effect of different toothpaste formulations used prior to dental bleaching with 35% hydrogen peroxide (HP) on the mineral content and surface morphology of enamel. METHODS: Seventy bovine enamel blocks (4×4×2 mm) were submitted to in vitro treatment protocols using a toothbrushing machine prior to dental bleaching or a placebo procedure (n=10) as proposed in the following groups: unbleached control (PLA), bleached control (HP), and brushing with differing toothpastes prior to HP bleaching, including: potassium nitrate toothpaste containing sodium fluoride (PN), sodium monofluorophosphate/MFP toothpaste (FT), arginine-carbonate (8% arginine) (PA) or arginine-carbonate (1...
March 2018: Operative Dentistry
Qiang Chen, Jiajia Jing, Hongfei Qi, Ifty Ahmed, Haiou Yang, Xianhu Liu, T L Lu, Aldo R Boccaccini
Structural and compositional modification of metallic implant surfaces is being actively investigated in order to achieve improved bone-to-implant bonding. In this study, a strategy to modify bulk metallic surfaces by electrophoretic deposition (EPD) of short phosphate glass fibers (sPGF) is presented. Random and aligned orientation of sPGF embedded in a polyacrylic acid (PAA) matrix is achieved by vertical and horizontal EPD, respectively. The influence of EPD parameters on the degree of alignment is investigated to pave the way for the fabrication of highly aligned sPGF structures in large areas...
March 5, 2018: ACS Applied Materials & Interfaces
Xanthippi Chatzistavrou, Anna Lefkelidou, Lambrini Papadopoulou, Eleni Pavlidou, Konstantinos M Paraskevopoulos, J Christopher Fenno, Susan Flannagan, Carlos González-Cabezas, Nikos Kotsanos, Petros Papagerakis
Aim: Antimicrobial and bioactive restorative materials are needed to develop a bacteria free environment and tight bond with the surrounding tissue, preventing the spread of secondary caries and thus extending the lifetime of dental restorations. The characteristic properties of new dental bioactive and antibacterial composites are presented in this work. The new composites have been microstructurally characterized and both long and short term properties have been studied. Methods: The Ag-doped sol-gel derived bioactive glass (Ag-BG) was incorporated into resin composite in concentrations 5, 10, and 15 wt...
2018: Frontiers in Physiology
Alfonso Pedone, Xiaojing Chen, Robert G Hill, Natalia Karpukhina
Oxyhalide-containing silicate glasses receive an increasing attention in recent years due to their extensive medical and dental applications. This manuscript reports the first detailed structural investigation using MD simulations in the context of chloride and mixed fluoride/chloride containing phosphosilicate bioactive glasses. It is shown that adding fluoride, chloride and mixed fluoride and chloride have not altered the Qn silicate distribution and phosphorus speciation significantly in all the glasses investigated...
March 2, 2018: Journal of Physical Chemistry. B
Sandra Sanchez-Salcedo, Gianluca Malavasi, Antonio J Salinas, Gigliola Lusvardi, Luca Rigamonti, Ledi Menabue, Maria Vallet-Regi
Beneficial effects in bone cell growth and antibacterial action are currently attributed to Ga3+ ions. Thus, they can be used to upgrade mesoporous bioactive glasses (MBGs), investigated for tissue engineering, whenever they released therapeutic amounts of gallium ions to the surrounding medium. Three gallium-enriched MBGs with composition (in mol %) x SiO₂- y CaO- z P₂O₅-5Ga₂O₃, being x = 70, y = 15, z = 10 for Ga_1 ; x = 80, y = 12, z = 3 for Ga_2 ; and x = 80, y = 15, z = 0 for Ga_3 , were investigated and compared with the gallium-free 80SiO₂-15CaO-5P₂O₅ MBG ( B )...
March 2, 2018: Materials
Lin Weng, Sunil Kumar Boda, Hongjun Wang, Matthew J Teusink, Franklin D Shuler, Jingwei Xie
An ideal synthetic bone graft is a combination of the porous and nanofibrous structure presented by natural bone tissue as well as osteoinductive biochemical factors such as bone morphogenetic protein 2 (BMP-2). In this work, ultralight 3D hybrid nanofiber aerogels composed of electrospun PLGA-collagen-gelatin and Sr-Cu codoped bioactive glass fibers with incorporation of heptaglutamate E7 domain specific BMP-2 peptides have been developed and evaluated for their potential in cranial bone defect healing. The nanofiber aerogels are surgically implanted into 8 mm × 1 mm (diameter × thickness) critical-sized defects created in rat calvariae...
March 2, 2018: Advanced Healthcare Materials
Hamada Elasyed, Acacio Rincon Romero, Giulia Molino, Chiara Vitale Brovarone, Enrico Bernardo
Highly porous bioactive glass-ceramic scaffolds were effectively fabricated by an inorganic gel casting technique, based on alkali activation and gelification, followed by viscous flow sintering. Glass powders, already known to yield a bioactive sintered glass-ceramic (CEL2) were dispersed in an alkaline solution, with partial dissolution of glass powders. The obtained glass suspensions underwent progressive hardening, by curing at low temperature (40 °C), owing to the formation of a C-S-H (calcium silicate hydrate) gel...
February 27, 2018: Materials
Lorenzo Drago, Marco Toscano, Marta Bottagisio
Bone defects caused by trauma or pathological events are major clinical and socioeconomic burdens. Thus, the efforts of regenerative medicine have been focused on the development of non-biodegradable materials resembling bone features. Consequently, the use of bioactive glass as a promising alternative to inert graft materials has been proposed. Bioactive glass is a synthetic silica-based material with excellent mechanical properties able to bond to the host bone tissue. Indeed, when immersed in physiological fluids, bioactive glass reacts, developing an apatite layer on the granule's surface, playing a key role in the osteogenesis process...
February 24, 2018: Materials
Timothy E L Douglas, Michal Dziadek, Svetlana Gorodzha, Jana Lišková, Gilles Brackman, Valérie Vanhoorne, Chris Vervaet, Lieve Balcaen, Maria Del Rosario Florez Garcia, Aldo R Boccaccini, Venera Weinhardt, Tilo Baumbach, Frank Vanhaecke, Tom Coenye, Lucie Bačáková, Maria A Surmeneva, Roman A Surmenev, Katarzyna Cholewa-Kowalska, Andre G Skirtach
Mineralization of hydrogel biomaterials is desirable to improve their suitability as materials for bone regeneration. In this study, gellan gum (GG) hydrogels were formed by simple mixing of GG solution with bioactive glass microparticles of 45S5 composition, leading to hydrogel formation by ion release from the amorphous bioactive glass microparticles. This resulted in novel injectable, self-gelling composites of GG hydrogels containing 20% bioactive glass. Gelation occurred within 20 minutes. Composites containing the standard 45S5 bioactive glass preparation were markedly less stiff...
February 28, 2018: Journal of Tissue Engineering and Regenerative Medicine
E P Erasmus, R Sule, O T Johnson, J Massera, I Sigalas
In this work, glasses within the borosilicate borophosphate and phosphate family were sintered into 3D porous scaffolds using 60 and 70 vol. % NH4 (HCO3 ) as a foaming agent. All scaffolds produced remained amorphous; apart from one third of the glasses which crystallized. All produced scaffolds had porosity >50% and interconnected pores in the range of 250-570 µm; as evidenced by µCT. The in-vitro dissolution of the scaffolds in SBF and changes in compression were assessed as a function of immersion time...
February 27, 2018: Scientific Reports
Zetao Chen, Lingling Chen, Runheng Liu, Yixiong Lin, Shoucheng Chen, Shifeier Lu, Zhengmei Lin, Zhuofan Chen, Chengtie Wu, Yin Xiao
A barrier membrane is a major component of guided bone regeneration (GBR), which is traditionally viewed as a physical barrier. Due to its "foreign body" nature, the implantation of a barrier membrane would inevitably modulate immune response and subsequently affect bone dynamics, which has long been neglected. To bridge this knowledge gap, we investigated the osteoimmunomodulatory effects of barrier collagen membranes. It is found that barrier collagen membranes elicit significant effects on modulating the osteoimmune response of macrophages, by upregulating the expression of pro-inflammatory cytokines (TNFα, IL-1β, IL-6, and IL-18) and osteogenic factors (BMP2/6, WNT10b, OSM)...
February 27, 2018: Biomaterials Science
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