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Bioactive glass

J Mesquita-Guimarães, M A Leite, J C M Souza, B Henriques, F S Silva, D Hotza, A R Boccaccini, M C Fredel
In this work, TiO2 ceramic scaffolds were fabricated by the replica method using polyurethane (PU) sponges. Suspensions with high solid content were used to achieve scaffolds with improved mechanical behavior. TiO2 ceramic suspensions were optimized by rheological studies using different additives. It was found that the composition with 0.5 wt% Darvan enhanced the covering of the sponge struts. PU sponges of 45 to 80 ppi (pore per inch) were well coated without clogging pores. A thermal treatment with varying holding times, temperatures and heating rates was adjusted...
October 17, 2016: Journal of Biomedical Materials Research. Part A
M E Galarraga-Vinueza, J Mesquita-Guimarães, R S Magini, J C M Souza, M C Fredel, A R Boccaccini
Bioactive glasses (BGs) are promising materials for bone repair due to their desirable properties such as osteoconductivity, biodegradability, angiogenic potential, and antibacterial activity. Ionic dissolution products from bioactive glasses increase the medium pH reducing surrounding bacteria proliferation. The activity of BGs against biofilm formation has been enhanced by incorporating organic antibacterial compounds. The aim of this review was to summarize evidence in literature which assesses the efficacy of antibacterial and anti-biofilm compounds embedded in bioactive glasses to prevent peri-implant infection during bone healing...
October 17, 2016: Journal of Biomedical Materials Research. Part A
Jenna N Harvestine, Nina L Vollmer, Steve S Ho, Christopher Andrew Zikry, Mark A Lee, J Kent Leach
Composite scaffolds of bioactive glass and poly(lactide-co-glycolide) provide advantages over homogenous scaffolds, yet their therapeutic potential can be improved by strategies that promote adhesion and present instructive cues to associated cells. Mesenchymal stem cell (MSC)-secreted extracellular matrix (ECM) enhances survival and function of associated cells. To synergize the benefits of an instructive ECM with composite scaffolds, we tested the capacity of ECM-coated composite scaffolds to promote cell persistence and resultant osteogenesis...
October 16, 2016: Biomacromolecules
Adel Dalilottojari, Bahman Delalat, Frances J Harding, Michaelia P Cockshell, Claudine S Bonder, Nicolas H Voelcker
Porous silicon (pSi) substrates are a promising platform for cell expansion, since pore size and chemistry can be tuned to control cell behavior. In addition, a variety of bioactives can be loaded into the pores and subsequently released to act on cells adherent to the substrate. Here we construct a cell microarray on plasma polymer coated pSi substrates that enables the simultaneous culture of human endothelial cells on printed immobilized protein factors while a second soluble growth factor is released from the same substrate...
October 15, 2016: Biomacromolecules
Wenlong Liu, Xiuli Dan, Ting Wang, William Weijia Lu, Haobo Pan
The development of an optimal animal model which could provide fast assessments of the interaction between bone and orthopaedic implants is essential for both pre-clinical and theoretical researches in the design of novel biomaterials. Compared with other animal models, mice have superiority in accessing the well-developed transgenic modification techniques (e.g. cell tracing, knock-off, knock-in ect.) which serve as powerful tools in studying molecular mechanisms. In this study, we introduced the establishment of a mouse model which is specifically tailored for the assessment of bone-implant interaction in a load-bearing bone marrow microenvironment and could potentially allow the molecular mechanism study of biomaterials by using transgenic technologies...
October 12, 2016: Tissue Engineering. Part C, Methods
Fang Yuan, De-Wen Zhang, Jing-Xin Liu, Ying-Lin Zhou, Xin-Xiang Zhang
Phytochemicals are essential secondary plant metabolites which play important roles in the areas of plant biochemistry, pharmacy and medical science because of their significant bioactivities. Conventional analysis of phytochemicals in plants needs a complex combination of different extraction and separation steps. Here a simple and universal method for profiling phytochemicals in a single plant cell was demonstrated based on high performance liquid chromatography-mass spectrometry. Single purple and colorless cell samples (about 15 μm in size) found in the outer layer of a young stem of Forsythia suspensa, just inside the cuticles were collected and transferred by glass micropipettes from cell monolayers...
September 22, 2016: Analyst
Cijun Shuai, Yiyuan Cao, Gao Dan, Chengde Gao, Pei Feng, Ping Wu
58s bioactive glass shows great potential for bone defects repair. However, at early repairing stage, the degradation rate of 58s glass is too fast due to the fast ion-exchange. At later repairing stage, the degradation rate of 58s glass is too slow due to the high dense mineral layer. In this work, Zinc oxide (ZnO) and β-tricalcium phosphate (β-TCP) were introduced into 58s glass bone scaffolds to improve the degradability. The results showed that ZnO could decrease the degradation rate and promote the stability of 58s glass at early repairing stage...
September 2, 2016: Bioengineered
Maha I Abdelfattah, Sherine A Nasry, Amani A Mostafa
AIM: The aim of this study was to analyze the cytotoxicity of ciprofloxacin (CIP) loaded on chitosan bioactive glass scaffold on human periodontal ligament stem cells (PLSCs) in vitro. MATERIALS AND METHODS: PLSCs obtained from human third molars, cultures treated with medium containing 15 x 15 mm chitosan/bioactive glass scaffolds without/with different concentration 0, 5, 10, and 20 % of CIP. A total of 15 x 10^3 cells were plated in 6 well plates. The attached cells of each group were harvested from the plates after 1, 4 and 8 days of culture to detect the viability of cells...
September 15, 2016: Open Access Macedonian Journal of Medical Sciences
Maziar Montazerian, Edgar Dutra Zanotto
The global market for dental materials is predicted to exceed 10 billion dollars by 2020. The main drivers for this growth are easing the workflow of dentists and increasing the comfort of patients. Therefore, remarkable research projects have been conducted and are currently underway to develop improved or new dental materials with enhanced properties or that can be processed using advanced technologies, such as CAD/CAM or 3D printing. Among these materials, zirconia, glass or polymer-infiltrated ceramics, and glass-ceramics (GCs) are of great importance...
October 4, 2016: Journal of Biomedical Materials Research. Part A
Ingrid Corazzari, Maura Tomatis, Francesco Turci, Sara Ferraris, Elisa Bertone, Enrico Prenesti, Enrica Vernè
Magnetite-containing glass-ceramics are promising bio-materials for replacing bone tissue after tumour resection. Thanks to their ferrimagnetic properties, they generate heat when subjected to an alternated magnetic field. In virtue of this they can be employed for the hyperthermic treatment of cancer. Moreover, grafting anti-cancer drugs onto their surface produces specific anti-neoplastic activity in these biomaterials. Gallic acid (GA) exhibits antiproliferative activity which renders it a promising candidate for anticancer applications...
September 23, 2016: Colloids and Surfaces. B, Biointerfaces
Jussi Sarin, Markus Hiltunen, Leena Hupa, Jaakko Pulkkinen, Pekka K Vallittu
Bioactive glass (BG)-containing fiber-reinforced composite implants, typically screw-retained, have started to be used clinically. In this study, we tested the mechanical strength of composites formed by a potential implant adhesive of n-butyl-2-cyanoacrylate glue and BG S53P4 particles. Water immersion for 3, 10 or 30 days had no adverse effect on the compression strength. When cyanoacrylate glue-BG-composites were subjected to simulated body fluid immersion, the average pH rose to 7.52 (SD 0.066) from the original value of 7...
September 28, 2016: Bio-medical Materials and Engineering
T De Caluwé, C W J Vercruysse, H A Declercq, D Schaubroeck, R M H Verbeeck, L C Martens
OBJECTIVE: Bioactive glasses (BAG) form, in contrast to formerly used implant materials, a stable bond with tissues, especially bone, when implanted. Nowadays BAGs are often mixed with a cement/composite that hardens in situ to broaden its applications in dentistry or orthopedics. The bioactivity and biocompatibility of possible BAG candidates for BAG-cement/composite development were evaluated. METHODS: Two fluoride containing BAGs were tested: a Na(+)-containing (45S5F), based on the first commercial BAG, and a Na(+)-free BAG (CF9), with a higher Ca(2+) and PO4(3-) content...
September 26, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
Anastasia Beketova, Nikolaos Poulakis, Athina Bakopoulou, Triantafillia Zorba, Lambrini Papadopoulou, Dimitrios Christofilos, Nikolaos Kantiranis, George A Zachariadis, Eleana Kontonasaki, Gerasimos A Kourouklis, Konstantinos M Paraskevopoulos, Petros Koidis
OBJECTIVES: Aims of this study were to investigate the optimal conditions of laser irradiation of a novel Bioactive Glass/Dental Ceramic-BP67 composite for acceleration of hydroxyapatite-HA formation and to assess cellular responses on the precipitated HA region. METHODS: BP67 (Bioactive Glass: 33.3%, Dental Ceramic: 66.7%) was fabricated by the sol-gel method. A laser assisted biomimetic-LAB process was applied to BP67 sintered specimens immersed in 1.5-times concentrated simulated body fluid-1...
September 24, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
Emanuela P Ferraz, Fabiola S Oliveira, Paulo T de Oliveira, Murilo C Crovace, Oscar Peitl-Filho, Marcio M Beloti, Adalberto L Rosa
The ability of Biosilicate® with two crystalline phases (BioS-2P) to drive osteoblast differentiation encourages the investigation of the cellular mechanisms involved in this process. Then, the aim of our study was to analyze the large-scale gene expression of osteoblasts grown on BioS-2P compared with Bioglass(®) 45S5 (45S5). Osteoblasts differentiated from rat bone marrow mesenchymal stem cells were cultured under osteogenic conditions on BioS-2P, 45S5 and polystyrene (control). After 10 days, the expression of 23,794 genes was analyzed using mRNA Sequencing and the data were validated by real-time PCR...
September 28, 2016: Journal of Biomedical Materials Research. Part A
Lin Wang, Mary A S Melo, Michael D Weir, Xianju Xie, Mark A Reynolds, Hockin H K Xu
OBJECTIVES: The occurrence of tooth root caries is increasing as the world population ages and tooth retention in seniors increases. Class V restorations with subgingival margins are difficult to clean and often lead to periodontitis. The objectives of this study were to develop a Class V composite containing dimethylaminohexadecyl methacrylate (DMAHDM) and nanoparticles of amorphous calcium phosphate (NACP), and investigate mechanical properties and the inhibition of six species of periodontitis-related biofilms for the first time...
September 23, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
Jun Ren, Kaikai Tian, Lingyun Jia, Xiuyou Han, Mingshan Zhao
A strategy for photo-induced covalent immobilization of proteins on phenol-functionalized surfaces is described. Under visible light irradiation, the reaction can be completed within seconds at ambient temperature, with high yields in aqueous solution of physiological conditions. Protein immobilization is based on ruthenium-catalyzed radical crosslinking reaction between proteins and phenol-modified surfaces, and the process has proven mild enough for lipase, Staphylococcus aureus protein A, and streptavidin to preserve their bioactivity...
September 27, 2016: Bioconjugate Chemistry
Yvette Alania, Marina D S Chiari, Marcela C Rodrigues, Victor E Arana-Chavez, Ana Helena A Bressiani, Flavio M Vichi, Roberto R Braga
OBJECTIVE: To evaluate the strength and ion release of experimental composites containing TEGDMA-functionalized calcium phosphate particles. METHODS: Seven composites containing equal parts (in mols) of BisGMA and TEGDMA and 60vol% of fillers were manipulated. Filler phase was constituted by silanized barium glass and 0% (control), 10% or 20% (volume) of dicalcium phosphate dihydrate (DPCD) particles, either non-functionalized or functionalized with two different TEDGMA contents...
September 21, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
A M Salem, S J Jones, I R Ellis, R G Chadwick
AIMS: Placement of a restoration to treat root caries disrupts many tissues. There is scope for the restorative material to interact with these to augment reductions in micro leakage afforded by an adhesive restorative material. OBJECTIVES: 1) To investigate the effects of incorporating bioactive molecules into a glass polyalkenoate (GPA) 2) To quantify the changes in physical properties of the material. METHODS: Biocompatibility of the GPA cement (Chemfil Superior, Dentsply De Trey, Konstanz, Germany) in unmodified and modified forms was ascertained using cell culture techniques...
November 2016: Journal of Dentistry
Chinmaya Mahapatra, Rajendra K Singh, Jung-Ju Kim, Kapil D Patel, Roman A Perez, Jun-Hyeog Jang, Hae-Won Kim
Providing an osteogenic stimulatory environment is a key strategy to construct stem cell-based bone-equivalent tissues. Here we design a stem cell delivering gel matrix made of collagen (Col) with bioactive glass nanocarriers (BGn) that incorporate osteogenic signaling molecule, fibroblast growth factor 18 (FGF18), a reservoir considered to cultivate and promote osteogenesis of mesenchymal stem cells (MSCs). The presence of BGn in the gel was shown to enhance the osteogenic differentiation of MSCs, possibly due to the therapeutic role of ions released...
October 4, 2016: ACS Applied Materials & Interfaces
Xiaoju Wang, Fang Cheng, Jun Liu, Jan-Henrik Smått, David Gepperth, Mika Lastusaari, Chunlin Xu, Leena Hupa
Biocomposites of copper-containing mesoporous bioactive glass (Cu-MBG) and nanofibrillated cellulose (NFC) were designated as potential dressing material for chronic wound healing. The phase composition and mesoporous micro-structure of the synthesized Cu-MBGs were elaborately characterized by combining several techniques, including TEM, SEM, XRD, SXAS and N2 physisorption. High bioactivity of the Cu-MBG was confirmed in stimulated body fluids in vitro. A controlled dissolution of Cu from the glass suggests Cu-MBG a suitable source for Cu release in wound healing dressings...
September 16, 2016: Acta Biomaterialia
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