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Bioactive glass

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https://www.readbyqxmd.com/read/29350101/biomimetic-composite-scaffold-sis-mbg-exhibits-high-osteogenic-and-angiogenic-capacity
#1
Tingfang Sun, Man Liu, Sheng Yao, Yanhui Ji, Zekang Xiong, Kai Tang, Kaifang Chen, Hu Yang, Xiao-Dong Guo
Biomaterials with excellent osteogenic and angiogenic activities are desirable to repair massive bone defects. Decellularized matrix from porcine small intestinal submucosa (SIS) has attracted particular attention for tissue regeneration because it has strong angiogenic effects and retains plentiful bioactive components. However, it has inferior osteoinductivity and osteoconductivity. In this study, we developed porous composite of SIS combined with mesoporous bioactive glass (SIS/MBG) with the goal of improving the mechanical and biological properties...
January 19, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29342851/laser-machining-and-in-vitro-assessment-of-wollastonite-tricalcium-phosphate-eutectic-glasses-and-glass-ceramics
#2
Daniel Sola, Lorena Grima
Bioactivity and ingrowth of ceramic implants is commonly enhanced by a suitable interconnected porous network. In this work, the laser machining of CaSiO₃‒Ca₃(PO₄)₂ biocompatible eutectic glass-ceramics and glasses was studied. For this purpose, 300 µm diameter craters were machined by using pulsed laser radiation at 532 nm with a pulsewidth in the nanosecond range. Machined samples were soaked in simulated body fluid for 2 months to assess the formation of a hydroxyapatite layer on the surface of the laser machined areas...
January 13, 2018: Materials
https://www.readbyqxmd.com/read/29342837/effect-of-exposed-surface-area-volume-and-environmental-ph-on-the-calcium-ion-release-of-three-commercially-available-tricalcium-silicate-based-dental-cements
#3
Sivaprakash Rajasekharan, Chris Vercruysse, Luc Martens, Ronald Verbeeck
Tricalcium silicate cements (TSC) are used in dental traumatology and endodontics for their bioactivity which is mostly attributed to formation of calcium hydroxide during TSC hydration and its subsequent release of calcium and hydroxide ions. The aim of this study was to determine the effect of volume (Vol), exposed surface area (ESA) and pH of surrounding medium on calcium ion release. Three commercially available hydraulic alkaline dental cements were mixed and condensed into cylindrical tubes of varying length and diameter (n = 6/group)...
January 13, 2018: Materials
https://www.readbyqxmd.com/read/29340351/effect-of-low-level-laser-on-the-healing-of-bone-defects-filled-with-autogenous-bone-or-bioactive-glass-in-vivo-study
#4
Guilherme Santos Moreira, Patrick Henry Machado Alves, Luis Augusto Esper, Michyele Cristhiane Sbrana, Gisele da Silva Dalben, Karin Hermana Neppelenbroek, Ana Lúcia Pompéia Fraga de Almeida
PURPOSE: This study evaluated the effect of low-level laser therapy (LLLT) on the healing of bone defects filled with autogenous bone or bioactive glass. MATERIALS AND METHODS: A critical size defect with 5-mm diameter was created on the calvaria of 60 adult male rats divided into 6 groups (n = 10): group C (control), group LLLT (LLLT - GaAlAs, wavelength of 780 nm, power of 100 mW, energy density of 210 J/cm2 per point during 60 seconds/point, in five points, only once, after creation of the surgical defect), group AB (autogenous bone), group AB+LLLT (autogenous bone + LLLT), group BG (bioactive glass), group BG+LLLT (bioactive glass + LLLT)...
January 2018: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29335193/damage-mechanisms-in-bioactive-glass-matrix-composites-under-uniaxial-compression
#5
Qifeng Jiang, Jewan Ismail, Fahmi Zaïri, Zhengwei Qu, Xiaobing Liu, Fahed Zaïri
The damage and crack resistance improvement of bioactive glass is of prime importance, particularly when applied to the repair of load-bearing bones. The present contribution is focused on the prediction of damage mechanisms and crack resistance under uniaxial compression of bioactive glass matrix composites reinforced with a particulate phase. In order to characterize the effects of voids and particles on the damage mechanisms and the macro-response, a two-step homogenization is performed by considering the two phases existing at two different scales: micro/meso through the homogenization of the porous matrix and then meso/macro through the periodic micro-field approach...
December 24, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29326518/toothpaste-use-protocol-with-dental-bleaching-for-a-conservative-treatment-case-reports
#6
Waldemir F Vieira-Junior, Thayla H N Gouveia, Bruna G Silva, Vanessa C P S Bueno, Flávio H B Aguiar, Débora A N L Lima
In-office bleaching is a treatment based on products that contain hydrogen peroxide (HP) while demonstrating whitening effectiveness. HP could promote alterations to surface morphologies and properties of dental tissues. The objective was describe a toothpaste protocol associated to bleaching therapy to promote a safer approach. Patient 1 (male) and Patient 2 (female) were attended, and toothbrushing (twice a day) with a dentifrice containing bioactive glass (BG) (NovaMin™) and fluoride was indicated before and during the treatment...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29318467/theoretical-and-experimental-studies-of-the-controlled-release-of-tetracycline-incorporated-into-bioactive-glasses
#7
Ângela L Andrade, Isabela A Militani, Katia J de Almeida, Jadson C Belchior, Sérgio C Dos Reis, Rosangela M F Costa E Silva, Rosana Z Domingues
Several authors have studied the release profile of drugs incorporated in different devices. However, to the best of our knowledge, although many studies have been done on the release of tetracycline, in these release devices, no study has investigated if the released compound is actually the tetracycline, or, instead, a degraded product. This approach is exploited here. In this work, we analyse the influence of two drying methods on the tetracycline delivery behaviour of synthesised glasses using the sol-gel process...
January 9, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29297551/bioactive-glass-particles-in-two-dimensional-and-three-dimensional-osteogenic-cell-cultures
#8
Luciana B Alves, Sérgio L S de Souza, Mario Taba, Arthur B Novaes, Paulo T de Oliveira, Daniela B Palioto
This study aimed to investigate the influence of a three-dimensional cell culture model and bioactive glass (BG) particles on the expression of osteoblastic phenotypes in rat calvaria osteogenic cells culture. Cells were seeded on two-dimensional (2D) and three-dimensional (3D) collagen with BG particles for up to 14 days. Cell viability and alkaline phosphatase (ALP) activity was performed. Cell morphology and immunolabeling of noncollagenous bone matrix proteins were assessed by epifluorescence and confocal microscopy...
May 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29288822/copper-containing-mesoporous-bioactive-glass-promotes-angiogenesis-in-an-in-vivo-zebrafish-model
#9
Lilian B Romero-Sánchez, Manuel Marí-Beffa, Paloma Carrillo, Miguel Ángel Medina, Aránzazu Díaz-Cuenca
The osteogenic and angiogenic responses of organisms to the ionic products of degradation of bioactive glasses (BGs) are being intensively investigated. The promotion of angiogenesis by copper (Cu) has been known for more than three decades. This element can be incorporated to delivery carriers, such as BGs, and the materials used in biological assays. In this work, Cu-containing mesoporous bioactive glass (MBG) in the SiO2-CaO-P2O5 compositional system was prepared incorporating 5% mol Cu (MBG-5Cu) by replacement of the corresponding amount of Ca...
December 27, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29287979/an-evaluation-of-the-biocompatibility-and-osseointegration-of-novel-glass-fiber-reinforced-composite-implants-in-vitro-and-in-vivo-studies
#10
Ya-Hui Chan, Wei-Zhen Lew, Emily Lu, Thomas Loretz, Luke Lu, Che-Tong Lin, Sheng-Wei Feng
OBJECTIVES: The aim of this study was to evaluate the in vitro biocompatibility and in vivo osseointegration of three novel bioactive glass fiber reinforced composite (GFRC) implants and to compare these with metal (Ti6Al4V) implants. METHODS: The surfaces of these experimental substrates were characterized by scanning electron microscopy (SEM), a 2D profilometer and by contact angle measurement. In vitro biological performance was assessed using MG-63 human osteoblast-like cell morphology, cell proliferation assays and the alkaline phosphatase (ALP) activity testing...
December 26, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29285031/efficacy-of-modified-bioactive-glass-for-dentin-remineralization-and-obstruction-of-dentinal-tubules
#11
Mahshid Saffarpour, Maryam Mohammadi, Mohammadreza Tahriri, Azadeh Zakerzadeh
Objectives: This study assessed the efficacy of modified bioactive glass (MBG) for dentin remineralization and obstruction of dentinal tubules. Materials and Methods: Thirty-six dentin discs were made from 20 third molars and were stored in 12% lactic acid solution for two weeks to induce demineralization. The samples were divided into three groups (n=12): 1- BG, 2- BG modified with 5% strontium (Sr) and 3- BG modified with 10% Sr. After applying the BG, the samples were stored in artificial saliva for 7, 14 and 21 days...
July 2017: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/29284945/comparison-of-marginal-periosteal-pedicle-graft-and-bioactive-glass-with-platelet-rich-fibrin-and-bioactive-glass-in-the-treatment-of-intrabony-defects-a-clinicoradiographic-study
#12
M S Yasaswini, K V Prabhakara Rao, P Tanuja, Narendra Reddy Motakatla
Introduction and Objectives: The objective of the study was to compare clinically and radiographically the regenerative potential of marginal periosteal pedicle graft (MPPG) or platelet-rich fibrin (PRF) with a bioactive glass in the treatment of two- and three-wall intrabony defects. Methods: A total of 28 sites (bilateral or contralateral infrabony defects) from 14 patient were treated with MPPG (Experimental site A) and the other site was treated with PRF (Experimental site B)...
November 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29279616/cytocompatibility-of-a-self-adhesive-gutta-percha-root-filling-material
#13
Joyce Nascimento, Miriam Zaccaro Scelza, Gutemberg Gomes Alves, Adriana Linhares, Antonio Canabarro, Jose Mauro Granjeiro, Gustavo De-Deus
Context: A novel root-filling material based on the incorporation of ultrafine alkaline bioactive glass particles (bioactive gutta-percha, [BGP]) was developed to work without sealer. Aim: In the present study, the objective was to verify the in vitro biological response to this material by assessing its cytocompatibility. Materials and Methods: Prototypes of BGP were compared to conventional gutta-percha (GP), dense polystyrene beads as a negative control and fragments of latex as a positive control...
May 2017: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29278321/design-and-evaluation-of-lyophilized-fibroblast-growth-factor-21-and-its-protection-against-ischemia-cerebral-injury
#14
Xuanxin Yang, Qi Hui, Bingjie Yu, Zhen Huang, Peipei Zhou, Panfeng Wang, Zhitao Wang, Shucai Pang, Jinghang Li, Hanshi Wang, Li Lin, Xiaokun Li, Xiaojie Wang
This study investigated the effect of the excipients, including glycine, mannitol, arginine, trehalose, sorbitol, and poloxamer188 on the stability of recombinant human fibroblast growth factor 21(FGF21) during the process of lyophilization and storage. The glass transition temperature (Tg), protein secondary structure, aggregation ratio and the bioactivity of lyophilized FGF21 were measured. We furthermore investigated the effect of FGF21 against ischemia cerebral injury using the middle cerebral artery occlusion (MCAO) model in rats...
December 26, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29251452/fluoride-release-and-re-release-from-a-bioactive-restorative-material
#15
Elizabeth May, Kevin J Donly
PURPOSE: To compare the amount of fluoride release and re-release of three different restorative materials. METHODS: The three restorative materials included a resin-based composite (Z100TM, 3M-ESPE), a resin-modified glass ionomer cement (VitremerTM, 3M-ESPE) and a bioactive material (Activa Bioactive-RestorativeTM, Pulpdent,). Ten disks were fabricated from each material. The disks were immersed in deionized water and stored. Samples were taken from each vial on Days 1, 7, 14 and 30 for fluoride ion analysis...
December 2017: American Journal of Dentistry
https://www.readbyqxmd.com/read/29246424/comparative-study-of-volumetric-changes-and-trabecular-microarchitecture-in-human-maxillary-sinus-bone-augmentation-with-bioactive-glass-and-autogenous-bone-graft-a-prospective-and-randomized-assessment
#16
R S Pereira, J D Menezes, J P Bonardi, G L Griza, R Okamoto, E Hochuli-Vieira
The aim of this study was to compare the volumetric changes and the new bone microarchitecture in human maxillary sinuses augmented with bioactive glass (Biogran) alone, bioactive glass combined with autogenous bone graft (1:1), or autogenous bone graft alone. Twelve maxillary sinuses were grafted with bioactive glass (group 1), nine with bioactive glass mixed with autogenous bone graft 1:1 (group 2), and 12 with autogenous bone graft (group 3). Patients underwent cone beam computed tomography 15days after the procedure to determine the initial volume of the graft (T1) and again 6 months later (T2)...
December 12, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29244726/potential-of-bioactive-glasses-for-cardiac-and-pulmonary-tissue-engineering
#17
REVIEW
Saeid Kargozar, Sepideh Hamzehlou, Francesco Baino
Repair and regeneration of disorders affecting cardiac and pulmonary tissues through tissue-engineering-based approaches is currently of particular interest. On this matter, different families of bioactive glasses (BGs) have recently been given much consideration with respect to treating refractory diseases of these tissues, such as myocardial infarction. The inherent properties of BGs, including their ability to bond to hard and soft tissues, to stimulate angiogenesis, and to elicit antimicrobial effects, along with their excellent biocompatibility, support these newly proposed strategies...
December 15, 2017: Materials
https://www.readbyqxmd.com/read/29240236/evaluation-of-osteoblast-differentiation-and-function-when-cultured-on-mesoporous-bioactive-glass-adsorbed-with-testosterone
#18
Kai Gao, Xiaoyan Wang, Qianqian Liu, Wei Chen, Gan Wang, Dongyi Zhang, Long Liu
Mesoporous bioactive glass (MBG), a kind of porous materials with great osteoconductive and osteoinductive ability, shows promising application in bone tissue engineering due to its high specific surface area, orderly channel structure and large pore volume. Here we reported that the proliferation, differentiation and mineralization were promoted in MC3T3-E1 cells cultured on MBG which adsorbed with testosterone (MBG/T). We found that transcriptional activity of Runx2 which is a critical transcription factor is increased in MC3T3-E1 cells cultured on MBG/T...
December 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29222837/low-melt-bioactive-glass-reinforced-3d-printing-akermanite-porous-cages-with-highly-improved-mechanical-properties-for-lumbar-spinal-fusion
#19
Xiurong Ke, Lei Zhang, Xianyan Yang, Juncheng Wang, Chen Zhuang, Zhouwen Jin, An Liu, Tengfei Zhao, Sanzhong Xu, Changyou Gao, Zhongru Gou, Guojing Yang
Although great strides have been made in medical technology, low back/neck pain and intervertebral disc degeneration initiated from disc degenerative disease remains a clinical challenge. Within the field of regenerative medicine therapy, we have sought to improve the biomechanical transformation of spinal fusion procedures conducted using biodegradable porous implants. Specifically, we have focused on developing mechanically strong bioceramic cages for spinal fusion and functional recovery. Herein we fabricated the akermanite (AKE) ceramic-based porous cages using low-melting bioactive glass (BG) and 3D printing technology...
December 9, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29208293/mesoporous-silica-based-bioactive-glasses-for-antibiotic-free-antibacterial-applications
#20
REVIEW
Seray Kaya, Mark Cresswell, Aldo R Boccaccini
Bioactive glasses (BGs) are being used in several biomedical applications, one of them being as antibacterial materials. BGs can be produced via melt-quenching technique or sol-gel method. Bactericidal silver-doped sol-gel derived mesoporous silica-based bioactive glasses were reported for the first time in 2000, having the composition 76SiO2-19CaO-2P2O5-3Ag2O (wt%) and a mean pore diameter of 28nm. This review paper discusses studies carried out exploring the potential antibacterial applications of drug-free mesoporous silica-based BGs...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
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