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https://www.readbyqxmd.com/read/28829531/the-relationship-between-social-capital-and-potential-resilience-in-individuals
#1
Daniel Hahn, Tierra L Willis, A Ruthie Christie, Samuel R Mathews
OBJECTIVE: To examine the relationship between social capital and potential resilience at the individual level from the perspective of emergency management. METHODS: The authors used an online survey tool to present various scales of measurement related to the variables of social capital and potential resilience. RESULTS: It was predicted that social capital and demographics, such as income, would be positively related to potential resilience...
May 2017: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/28829420/measuring-mrna-levels-over-time-during-the-yeast-s-cerevisiae-hypoxic-response
#2
Stephen D Willis, A K M Nawshad Hossian, Nathan Evans, Mark J Hickman
Complex changes in gene expression typically mediate a large portion of a cellular response. Each gene may change expression with unique kinetics as the gene is regulated by the particular timing of one of many stimuli, signaling pathways or secondary effects. In order to capture the entire gene expression response to hypoxia in the yeast S. cerevisiae, RNA-seq analysis was used to monitor the mRNA levels of all genes at specific times after exposure to hypoxia. Hypoxia was established by growing cells in ~100% N2 gas...
August 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28828676/therapeutic-applications-of-extracellular-vesicles-perspectives-from-newborn-medicine
#3
Gareth R Willis, Stella Kourembanas, S Alex Mitsialis
With the advancements in antenatal steroid therapies and surfactant replacement, current clinical practices in neonatal intensive care units allow the survival of infants at very low gestational age. Despite these advances, there continues to be significant morbidity associated with extreme preterm birth that includes both short-term and long-term cardiorespiratory impairment. With no effective single therapy in preventing or treating developmental lung injuries, the need for new tools to treat and reduce risk of complications associated with extreme preterm birth is urgent...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28828535/evaluating-the-completeness-of-hiv-surveillance-using-capture-recapture-models-alameda-county-california
#4
Paul Wesson, Richard Lechtenberg, Arthur Reingold, Willi McFarland, Neena Murgai
HIV prevalence in Alameda County (including Oakland) is among the highest in California, yet the case registry may under-appreciate the full burden of disease. Using lists from health care facilities serving socioeconomically diverse populations and the HIV surveillance list, we applied capture-recapture methods to evaluate the completeness of the surveillance system by estimating the number of diagnosed people living with HIV and seeking care in Alameda County in 2013. Of the 5376 unique individuals reported from the lists, 397 were missing from the surveillance list...
August 21, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28822944/pregnancy-outcome-after-cervical-conisation-a-2nd-retrospective-cohort-study-in-the-leuven-university-hospital
#5
Kim van Velthoven, Willy Poppe, Hannah Verschuere, Marc Arbyn
OBJECTIVE: To evaluate whether the dimensions of the cones removed during large loop excision of the transformation zone have decreased over time. Secondly, whether these changes were associated with a lower risk of obstetrical harms on a subsequent pregnancy. STUDY DESIGN: A retrospective matched cohort study was performed in a tertiary referral unit in Belgium. A total of 97 women were identified from a database of women who underwent excisional treatment for cervical precancer between January 1st, 2004 and December 31st, 2012, and delivered before December 31st, 2014...
June 29, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28821289/transcriptome-wide-analyses-indicate-mitochondrial-responses-to-particulate-air-pollution-exposure
#6
Ellen Winckelmans, Tim S Nawrot, Maria Tsamou, Elly Den Hond, Willy Baeyens, Jos Kleinjans, Wouter Lefebvre, Nicolas Van Larebeke, Martien Peusens, Michelle Plusquin, Hans Reynders, Greet Schoeters, Charlotte Vanpoucke, Theo M de Kok, Karen Vrijens
BACKGROUND: Due to their lack of repair capacity mitochondria are critical targets for environmental toxicants. We studied genes and pathways reflecting mitochondrial responses to short- and medium-term PM10 exposure. METHODS: Whole genome gene expression was measured in peripheral blood of 98 adults (49% women). We performed linear regression analyses stratified by sex and adjusted for individual and temporal characteristics to investigate alterations in gene expression induced by short-term (week before blood sampling) and medium-term (month before blood sampling) PM10 exposure...
August 18, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28818603/effects-of-suspended-sediments-and-nutrient-enrichment-on-juvenile-corals
#7
Adriana Humanes, Artur Fink, Bette L Willis, Katharina E Fabricius, Dirk de Beer, Andrew P Negri
Three to six-month-old juveniles of Acropora tenuis, A. millepora and Pocillopora acuta were experimentally co-exposed to nutrient enrichment and suspended sediments (without light attenuation or sediment deposition) for 40days. Suspended sediments reduced survivorship of A. millepora strongly, proportional to the sediment concentration, but not in A. tenuis or P. acuta juveniles. However, juvenile growth of the latter two species was reduced to less than half or to zero, respectively. Additionally, suspended sediments increased effective quantum yields of symbionts associated with A...
August 14, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28818162/impact-of-a-social-media-group-page-on-undergraduate-medical-physiology-learning
#8
Tania Ahmed Shakoori, Usman Mahboob, Janet Strivens, Ian Willis
OBJECTIVE: To investigate the impact of associating classroom learning of medical physiology with a Facebook group page in an all-women medical college of a conservative small city in Pakistan. STUDY DESIGN: Qualitative interpretivist study using semi-structured interviews. PLACE AND DURATION OF STUDY: Women Medical College Abbottabad, Pakistan, from March to December 2014. METHODOLOGY: Aclosed Facebook study group was established at a local medical college in Pakistan...
July 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28818004/identification-and-treatment-of-augmentation-in-patients-with-restless-legs-syndrome-practical-recommendations
#9
James Geyer, Richard Bogan
Restless legs syndrome (RLS) is a chronic disorder causing clinically significant discomfort to approximately 3% of adults. Although RLS was first identified centuries ago, our understanding of this disorder, its causes, and its treatments is still evolving. In particular, our knowledge of the potential negative effects of RLS treatments, including dopaminergic augmentation, continues to expand. Augmentation, which refers to a paradoxical treatment-related increase in RLS symptoms, has been associated with all three dopamine agonists approved for the treatment of RLS - rotigotine, pramipexole, and ropinirole...
August 18, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28816485/risks-resources-and-depressive-symptomatology-among-marshallese-adolescents
#10
Kevin M Fitzpatrick, Don Willis
This study examined risks and resources to assess depressive symptom variation among a sample of Marshallese adolescents attending a Northwest Arkansas high school. A self-administered questionnaire was completed by 10th-12th-grade students (N = 1,493). With a general response rate in excess of 78%, the subsample (n = 208) represented 75% of all Marshallese students attending the high school and approximately 9% of the total K-12 Marshallese population. Average depressive symptom (CES-D) scores for Marshallese adolescents were 17...
August 17, 2017: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/28815621/red-blood-cell-sedimentation-of-apheresis-granulocytes
#11
Michelle A Lodermeier, Karen M Byrne, Willy A Flegel
Sedimentation of Apheresis Granulocyte components removes red blood cells. It is used to increase the blood donor pool when blood group-compatible donors cannot be recruited for a patient because of a major ABO incompatibility or incompatible red blood cell antibodies in the recipient. Because granulocytes have little ABO and few other red blood cell antigens on their membrane, such incompatibility lies mostly with the contaminating red blood cells. Video Clip S1 shows the process of red blood cell sedimentation of an Apheresis Granulocyte component...
August 16, 2017: Transfusion
https://www.readbyqxmd.com/read/28814662/irgm1-coordinately-regulates-autoimmunity-and-host-defense-at-select-mucosal-surfaces
#12
Kathleen M Azzam, Jennifer H Madenspacher, Derek W Cain, Lihua Lai, Kymberly M Gowdy, Prashant Rai, Kyathanahalli Janardhan, Natasha Clayton, Willie Cunningham, Heather Jensen, Preeyam S Patel, John F Kearney, Gregory A Taylor, Michael B Fessler
The pathogenesis of primary Sjogren's syndrome (SS), an autoimmune disease that targets the mucosa of exocrine tissues, is poorly understood. Although several mouse models have been developed that display features of SS, most of these are within the larger context of a lupus-like presentation. Immunity-related GTPase family M protein 1 (Irgm1) is an interferon-inducible cytoplasmic GTPase that is reported to regulate autophagy and mitochondrial homeostasis. Here, we report that naive Irgm1-/- mice display lymphocytic infiltration of multiple mucosal tissues including the lung in a manner reminiscent of SS, together with IgA class-predominant autoantibodies including anti-Ro and anti-La...
August 17, 2017: JCI Insight
https://www.readbyqxmd.com/read/28814455/national-randomized-controlled-trial-of-virtual-house-calls-for-parkinson-disease
#13
Christopher A Beck, Denise B Beran, Kevin M Biglan, Cynthia M Boyd, E Ray Dorsey, Peter N Schmidt, Richard Simone, Allison W Willis, Nicholas B Galifianakis, Maya Katz, Caroline M Tanner, Kristen Dodenhoff, Jason Aldred, Julie Carter, Andrew Fraser, Joohi Jimenez-Shahed, Christine Hunter, Meredith Spindler, Suzanne Reichwein, Zoltan Mari, Becky Dunlop, John C Morgan, Dedi McLane, Patrick Hickey, Lisa Gauger, Irene Hegeman Richard, Nicte I Mejia, Grace Bwala, Martha Nance, Ludy C Shih, Carlos Singer, Silvia Vargas-Parra, Cindy Zadikoff, Natalia Okon, Andrew Feigin, Jean Ayan, Christina Vaughan, Rajesh Pahwa, Rohit Dhall, Anhar Hassan, Steven DeMello, Sara S Riggare, Paul Wicks, Meredith A Achey, Molly J Elson, Steven Goldenthal, H Tait Keenan, Ryan Korn, Heidi Schwarz, Saloni Sharma, E Anna Stevenson, William Zhu
OBJECTIVE: To determine whether providing remote neurologic care into the homes of people with Parkinson disease (PD) is feasible, beneficial, and valuable. METHODS: In a 1-year randomized controlled trial, we compared usual care to usual care supplemented by 4 virtual visits via video conferencing from a remote specialist into patients' homes. Primary outcome measures were feasibility, as measured by the proportion who completed at least one virtual visit and the proportion of virtual visits completed on time; and efficacy, as measured by the change in the Parkinson's Disease Questionnaire-39, a quality of life scale...
August 16, 2017: Neurology
https://www.readbyqxmd.com/read/28814167/cardio-cephalic-neural-crest-syndrome-a-novel-hypothesis-of-vascular-neurocristopathy
#14
M Komiyama
A novel hypothesis proposes that "cardio-cephalic neural crest (NC) syndrome," i.e. cephalic NC including cardiac NC, contributes to the concurrent occurrence of vascular diseases in the cardio- and cerebrovascular regions. NC is a transient structure present in early embryogenesis. Cephalic NC provides mesenchymal cells to the vascular media in these regions. Concurrent cardio- and cerebrovascular lesions have been reported in PHACE syndrome, ACTA2 mutation syndrome, and less frequently in the spontaneous occlusion of the circle of Willis (so-called moyamoya disease)...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28812590/island-biodiversity-conservation-needs-palaeoecology
#15
Sandra Nogué, Lea de Nascimento, Cynthia A Froyd, Janet M Wilmshurst, Erik J de Boer, Emily E D Coffey, Robert J Whittaker, José María Fernández-Palacios, Kathy J Willis
The discovery and colonization of islands by humans has invariably resulted in their widespread ecological transformation. The small and isolated populations of many island taxa, and their evolution in the absence of humans and their introduced taxa, mean that they are particularly vulnerable to human activities. Consequently, even the most degraded islands are a focus for restoration, eradication, and monitoring programmes to protect the remaining endemic and/or relict populations. Here, we build a framework that incorporates an assessment of the degree of change from multiple baseline reference periods using long-term ecological data...
June 22, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28811517/heritability-of-the-symbiodinium-community-in-vertically-and-horizontally-transmitting-broadcast-spawning-corals
#16
Kate M Quigley, Bette L Willis, Line K Bay
The dinoflagellate-coral partnership influences the coral holobiont's tolerance to thermal stress and bleaching. However, the comparative roles of host genetic versus environmental factors in determining the composition of this symbiosis are largely unknown. Here we quantify the heritability of the initial Symbiodinium communities for two broadcast-spawning corals with different symbiont transmission modes: Acropora tenuis has environmental acquisition, whereas Montipora digitata has maternal transmission. Using high throughput sequencing of the ITS-2 region to characterize communities in parents, juveniles and eggs, we describe previously undocumented Symbiodinium diversity and dynamics in both corals...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810137/time-gated-luminescence-imaging-of-singlet-oxygen-photoinduced-by-fluoroquinolones-and-functionalized-graphenes-in-daphnia-magna
#17
Tianlie Luo, Jingwen Chen, Bo Song, Hua Ma, Zhiqiang Fu, Willie J G M Peijnenburg
Singlet oxygen ((1)O2) can be photogenerated by photoactive xenobiotics and is capable of causing adverse effects due to its electrophilicity and its high reactivity with biological molecules. Detection of the production and distribution of (1)O2 in living organisms is therefore of great importance. In this study, a luminescent probe ATTA-Eu(3+) combined with time-gated luminescence imaging was adopted to detect the distribution and temporal variation of (1)O2 photoinduced by fluoroquinolone antibiotics and carboxylated/aminated graphenes in Daphnia magna...
July 29, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28809811/mutation-clusters-from-cancer-exome
#18
Zura Kakushadze, Willie Yu
We apply our statistically deterministic machine learning/clustering algorithm *K-means (recently developed in https://ssrn.com/abstract=2908286) to 10,656 published exome samples for 32 cancer types. A majority of cancer types exhibit a mutation clustering structure. Our results are in-sample stable. They are also out-of-sample stable when applied to 1389 published genome samples across 14 cancer types. In contrast, we find in- and out-of-sample instabilities in cancer signatures extracted from exome samples via nonnegative matrix factorization (NMF), a computationally-costly and non-deterministic method...
August 15, 2017: Genes
https://www.readbyqxmd.com/read/28809697/geometric-and-photometric-consistency-in-a-mixed-video-and-galvanoscopic-scanning-laser-projection-mapping-system
#19
Petar Pjanic, Simon Willi, Anselm Grundhofer
We present a geometric calibration method to accurately register a galvanoscopic scanning laser projection system (GLP) based on 2D vector input data onto an arbitrarily complex 3D-shaped projection surface. This method allows for accurate merging of 3D vertex data displayed on the laser projector with geometrically calibrated standard rasterization-based video projectors that are registered to the same geometry. Because laser projectors send out a laser light beam via galvanoscopic mirrors, a standard pinhole model calibration procedure that is normally used for pixel raster displays projecting structured light patterns, such as Gray codes, cannot be carried out directly with sufficient accuracy as the rays do not converge into a single point...
August 10, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28809495/a-copper-i-catalyzed-addition-annulation-sequence-for-the-two-component-synthesis-of-%C3%AE-ylidenebutenolides
#20
Sangwon Seo, Michael C Willis
A highly efficient Cu(I)-catalyzed addition/annulation sequence has been developed for the synthesis of (Z)-ylidenebutenolides employing readily available α-ketoacids and alkynes as substrates. The reactions employ a simple commercially available Cu(I)-catalyst, display good substrate scope, and deliver products with high stereoselectivity. The synthetic utility of the method is demonstrated by the straightforward derivatization of the ylidenebutenolides into a diverse range of heterocycles, and also by the preparation of the natural product bovolide, and analogs thereof...
August 15, 2017: Organic Letters
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