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S Işık, M Karaman, S Çilaker Micili, Ş Çağlayan-Sözmen, H Alper Bağrıyanık, Z Arıkan-Ayyıldız, N Uzuner, Ö Karaman
BACKGROUND AND AIMS: In previous studies, anti-inflammatory, anti-apoptotic and immunomodulatory effects of ursodeoxycholic acid (UDCA) on liver diseases have been shown. In this study, we aimed to investigate the effects of UDCA on airway remodelling, epithelial apoptosis, and T Helper (Th)-2 derived cytokine levels in a murine model of chronic asthma. METHODS: Twenty-seven BALB/c mice were divided into five groups; PBS-Control, OVA-Placebo, OVA-50mg/kg UDCA, OVA-150mg/kg UDCA, OVA-Dexamethasone...
July 2017: Allergologia et Immunopathologia
S Işık, A Çağlar, B Eroğlu-Filibeli, Ş Çağlayan-Sözmen, Z Arıkan-Ayyıldız, S Asilsoy, N Uzuner
BACKGROUND: Allergen-specific immunotherapy (ASI) is the only effective treatment for allergic respiratory diseases which has the potential to change the natural course of the disease. In this present study we aimed to evaluate the paediatricians' knowledge, perspectives and attitudes about ASI for allergic respiratory diseases. MATERIALS AND METHODS: The study was conducted between September 2014 - January 2015. A survey of 25 questions assessing paediatricians' knowledge, perceptions and attitudes about ASI was developed by an expert panel and applied by physicians in hospitals in Izmir, Turkey, where the paediatricians work...
March 2017: Allergologia et Immunopathologia
Z Arıkan-Ayyıldız, M Karaman, S Özbal, A Bağrıyanık, O Yilmaz, Ö Karaman, N Uzuner
BACKGROUND: Parthenolide is the active constituent of the plant 'Tanacetum parthenium' (Feverfew) which has been used for centuries as a folk remedy for inflammatory conditions. AIM OF THE STUDY: In this study we aimed to investigate the effects of parthenolide in a murine model of chronic asthma. MATERIALS AND METHODS: Thirty-five BALB/c mice were divided into five groups; I (control), II (placebo), III (dexamethasone), IV (parthenolide) and V (dexamethasone and parthenolide combination)...
January 2017: Allergologia et Immunopathologia
G Tekgol Uzuner, N Uzuner
AIM: Obstructive sleep apnea syndrome (OSAS) has been implicated as an independent risk factor for stroke. There are data suggesting the presence of lower cerebrovascular reactivity (CVR) as determined by transcranial Doppler (TCD) in patients with OSAS. We concurrently investigated neurovascular coupling (NVC) with visual stimulation, and CVR using breath-holding (BH) test on TCD in patients with OSAS. MATERIALS AND METHODS: Data were collected in 49 patients with moderate to severe OSAS, and compared to 15 healthy subjects matched for age and risk factors...
January 2017: International Journal of Neuroscience
T Çankaya, Z Arikan-Ayyildiz, E Bora, N Uzuner, A Ulgenalp
AIM: Common mutation detection panels are usually used in clinical practice in most of the centers of our country in order to demonstrate mutations of cystic fibrosis (CF) patients. But heterogenicity of CFTR mutations in Turkey makes identification of CFTR mutations extremely difficult while using common mutation detection panels. METHODS: In this report, we described our experience and findings in offering sequencing of the CFTR gene to 17 patients in which no mutations were identified by common mutation analysis...
October 2015: Minerva Pediatrica
Z Arıkan-Ayyıldız, S Isık, S Babus, R Ucku, S Caglayan-Sozmen, O Karaman, N Uzuner
BACKGROUND: Reported prevalence of the insect stings and rates of allergic reactions vary among studies. The aim of the present study was to carry out the first epidemiological study on the prevalence of Hymenoptera allergy among school children in Izmir, Turkey. METHODS: We planned to reach 6100 children, assuming the frequency of allergic reactions to Hymenoptera stings as 20%. Thirty-seven and eight schools were chosen from rural and urban areas, respectively...
January 2016: Allergologia et Immunopathologia
N Saltoglu, M Yemisen, O Ergonul, A Kadanali, G Karagoz, A Batirel, O Ak, H Eraksoy, A Cagatay, A Vatan, G Sengoz, F Pehlivanoglu, T Aslan, Y Akkoyunlu, D Engin, N Ceran, B Erturk, L Mulazimoglu, O Oncul, H Ay, F Sargin, N Ozgunes, F Simsek, T Yildirmak, N Tuna, O Karabay, K Yasar, N Uzun, Y Kucukardali, M Sonmezoglu, F Yilmaz, U Tozalgan, S Ozer, M Ozyazar
We aimed to investigate the predictors for limb loss among patients with diabetes who have complicated skin/soft-tissue infections. In this observational study, consecutive patients with diabetic foot infection (DFI) from 17 centres in Turkey, between May 2011 and May 2013 were included. The Turkish DFI Working Group performed the study. Predictors of limb loss were investigated by multivariate analysis. In total, 455 patients with DFI were included. Median age was 61 years, 68% were male, 65% of the patients were hospitalized, 52% of the patients had used antibiotics within the last month, and 121 (27%) had osteomyelitis...
July 2015: Clinical Microbiology and Infection
D Ozturk-Engin, H Erdem, S Gencer, S Kaya, A I Baran, A Batirel, R Tekin, M K Celen, A Denk, S Guler, M Ulug, H Turan, A U Pekok, G Mermut, S Kaya, M Tasbakan, N Tulek, Y Cag, A Inan, A Yalci, C Ataman-Hatipoglu, I Gonen, A Dogan-Celik, F Bozkurt, S Gulsun, M Sunnetcioglu, T Guven, F Duygu, E Parlak, H Sozen, S Tosun, T Demirdal, E Guclu, O Karabay, N Uzun, O Gunal, H Diktas, A Haykir-Solay, A Erbay, C Kader, O Aydin, A Erdem, N Elaldi, A Kadanali, Z Yulugkural, L Gorenek, M Altındis, S Bolukcu, C Agalar, N Ormeci
Brucellosis is a zoonotic disease that primarily affects the reticuloendothelial system. But, the extent of liver damage in due course of the disease is unclear. This study included 325 brucellosis patients with significant hepatobiliary involvement identified with microbiological analyses from 30 centers between 2000 and 2013. The patients with ≥5 times of the upper limit of normal for aminotransferases, total bilirubin level ≥2 mg/dl or local liver lesions were enrolled. Clinical hepatitis was detected in 284 patients (87...
July 2014: European Journal of Clinical Microbiology & Infectious Diseases
Z Arıkan-Ayyıldız, M Karaman, T Tuncel, M Kiray, A Bağrıyanık, O Yilmaz, N Uzuner, O Karaman
BACKGROUND: Increased arginase activity in the airways induces reduced bioavailability of L-arginine and cause deficiency of bronchodilatating and anti-inflammatory nitric oxide (NO). Therefore, arginine and arginase inhibitors may have therapeutic potential in the treatment of asthma. Using a murine model of asthma, we aimed to investigate the effects of inhaled L-arginine and arginase inhibitor Nω-hydroxy-nor-L-arginine (nor-NOHA) and co-treatment on airway histology of asthmatic lung tissue...
July 2014: Allergologia et Immunopathologia
E Bora, R Soylar, Z Arıkan-Ayyıldız, N Uzuner, Ö Giray-Bozkaya, D Erçal, Ö Karaman, A Ülgenalp
BACKGROUND: Polymorphisms of plasminogen activator inhibitor-1 (PAI-1) and angiotensin-converting enzyme (ACE) genes have been implicated in susceptibility to asthma. In this study, we aimed to investigate whether there was any association between childhood asthma and polymorphisms of the PAI-1 and ACE genes. METHODS: Two hundred and three Turkish children aged 5-15 years, including 102 asthmatic patients and 101 healthy control subjects were included in this study...
January 2013: Allergologia et Immunopathologia
M Karaman, F Firinci, S Cilaker, P Uysal, K Tugyan, O Yilmaz, N Uzuner, O Karaman
BACKGROUND: Curcumin, a dietary pigment responsible for the yellow colour of curry, has been used for the treatment of inflammatory diseases and exhibits a variety of pharmacological effects. METHODS: Forty-two BALB/c mice were divided into six groups: I, II, III, IV, V, and control group. All groups except the controls were sensitised and challenged with ovalbumin. Group I received nebulised saline in challenge period. Mice in groups II, III, IV, and V were administered curcumin at a dose of 10mg/kg, curcumin 20mg/kg, dexamethasone 1mg/kg, and dimethyl sulfoxide 1mg/kg, respectively, intraperitoneally once a day for the final 5 days of the challenge period...
July 2012: Allergologia et Immunopathologia
B E Sekerel, O U Soyer, O Keskin, N Uzuner, M Yazicioglu, M Kiliç, H Artaç, S Ozmen, D Can, D Zeyrek, H Cokugras, Y Canitez, M Aydogan, S Kuyucu, A Inal, F Gurkan, F Orhan, O Yilmaz, A B Boz, F Tahan, O Cevit
INTRODUCTION: The reliability and validity of Turkish version of Childhood Asthma Control Test (C-ACT). PURPOSE: The management of asthma is an important as well as difficult issue of physician's daily practice particularly in busy clinical settings. C-ACT was created to identify asthma control levels in children aged 4-11 years. Our aim was to evaluate the reliability, validity and responsiveness of C-ACT in a Turkish sample of children with asthma. METHOD: In this multicenter study, 368 children were enrolled...
May 2012: Quality of Life Research
T Tuncel, P Uysal, A B Hocaoglu, D O Erge, O Karaman, N Uzuner
BACKGROUND: Asthma is the most common chronic disease of childhood in industrialised countries. T helper-2 (Th-2) cells, mast cells and eosinophils have a role in inflammation of asthma. Recently it was shown that platelets also play a role in asthma. Mean platelet volume shows platelet size and reflects platelet activation. OBJECTIVE: The aim of this retrospective study is to evaluate levels of mean platelet volume in asthmatic patients during asymptomatic periods and exacerbations compared with healthy controls...
March 2012: Allergologia et Immunopathologia
M Karaman, F Firinci, M Kiray, T Tuncel, A Bagriyanik, O Yilmaz, N Uzuner, O Karaman
BACKGROUND: Erythropoietin (EPO) is originally defined as a haematopoietic growth factor, but also has anti-inflammatory effects through cytokine modulation. This anti-inflammatory and cytokine modulating effect has not been investigated for the treatment of asthma. We aimed to determine the beneficial effects of erythropoietin on lung histology of murine model of chronic asthma. METHODS: Thirty-five BALB/c mice were divided into five groups: I; II; III; IV; and control group...
March 2012: Allergologia et Immunopathologia
T Tuncel, P Uysal, A Babayigit Hocaoglu, D Olmez Erge, F Firinci, O Karaman, N Uzuner
No abstract text is available yet for this article.
March 2011: Allergologia et Immunopathologia
Alexander Y Gur, D Gücüyener, A D Korczyn, N Uzüner, Y Gilutz, G Ozdemir, N M Bornstein
OBJECTIVES: Cerebral hemodynamic features of patients with post-stroke dementia (PSD) are still obscure. We compared cerebral vasomotor reactivity (VMR) assessed in the acute phase of ischemic stroke (IS) in patients with and without PSD. VMR was also assessed and compared in demented and non-demented patients in the late phase of IS. MATERIALS AND METHODS: VMR was assessed by transcranial Doppler and the Diamox test (1 g acetazolamide i.v.). PSD was confirmed by the National Institute of Neurological Disorders and Stroke and the Association Internationale pour la Recherche et I'Enseignement en Neurosciences (NINDS-AIREN) and the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria...
December 2010: Acta Neurologica Scandinavica
D Olmez, A Babayigit, G Erbil, O Karaman, A Bagriyanik, O Yilmaz, N Uzuner
BACKGROUND: No studies to date have compared mouse models of asthma by evaluating airway histopathology. OBJECTIVE: To compare 2 such models by studying chronic histopathologic changes of the airways using light and electron microscopy. METHODS: Twenty-one male BALB/c mice were divided into 3 groups: a nebulization group sensitized via an intraperitoneal injection of 10 microg ovalbumin on days 0 and 14 and exposed to 2.5% aerosolized ovalbumin 3 days a week over the subsequent 8 weeks; an intranasal group sensitized via 2 intraperitoneal injections of 100 microg ovalbumin on days 0 and 14 and administered an intranasal dose of 500 microg ovalbumin on days 14, 27, 28, 29, 47, 61, 73, 74, and 75; and a control group that received nothing...
2009: Journal of Investigational Allergology & Clinical Immunology
D Olmez, A Babayigit, H Arslan, N Uzuner, Y Ozturk, O Karaman, H Cakmakci
Human Echinococcus infection still remains an important health problem in endemic regions. Herein, we report a 5-year-old boy with hydatid disease who has spleen, lung, kidney and liver involvement simultaneously. To our knowledge, there is no pediatric case with hydatid disease in the literature reporting simultaneous involvement of spleen, kidney, liver and lungs as in our case.
December 2008: Journal of Tropical Pediatrics
N Uzuner, S Ozkan, N Cinar
A close relationship between multiple sclerosis (MS) lesions and the cerebral vasculature has long been recognised. Some studies have suggested that vascular endothelial cell activation might be an early event in the evolution of MS, and demyelisation may have an ischemic basis in this condition. Hypoxia caused by breath holding (BH) results in autoregulatory vasodilatation, and an increase in CBF to the cortex. The increased CBF can be evaluated by transcranial Doppler (TCD), and can provide information about the vascular integrity...
July 2007: Multiple Sclerosis: Clinical and Laboratory Research
D Gücüyener, C Ugur, N Uzuner, G Ozdemir
No abstract text is available yet for this article.
May 2000: Annals of Saudi Medicine
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